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Byline: Angela. Estenaga, Rafael. Vallejo History A 63-year-old man consulted with a 3-month history of an asymptomatic nodule on the right temple, that was slowly increasing in size. He had [...]

Microsecretory adenocarcinoma (MSA) is a newly described salivary gland tumor harboring a characteristic balanced chromosomal translocation resulting in MEF2C::SS18 gene fusion. Six primary cutaneous MSA cases have been recently described. We report three additional cases confirming the relevance of this recently identified entity of primary cutaneous adnexal tumor. Three patients aged 53‐, 64‐ and 78‐year‐old were retrospectively diagnosed with MSA of the skin (MSAS) as consultation cases of the CARADERM (CAncers RAres DERMatologiques) national network. The clinical presentation was an indolent nodule on the upper extremities. There was no history of salivary gland tumor. Histopathologically, the tumors presented as dermal nodular proliferation with slightly infiltrative borders, composed of cribriform and microcystic structures with abundant myxoid intraluminal secretion embedded in a fibromyxoid stroma. They diffusely expressed cytokeratin 8 and SOX10, focally p63 and heterogeneously smooth muscle actin. All tumors harbored the MEF2C::SS18 gene fusion. A complete surgical excision was performed. No local recurrence or distant metastases were observed so far (follow‐up: 17, 38, and 45 months). MSAS is the cutaneous homologue of MSA of the salivary gland, a low‐grade adnexal neoplasm whose prognosis seems to be excellent once the complete removal of the tumor is assured. [ABSTRACT FROM AUTHOR]

This article discusses the successful treatment of epidermal nevus (EN) in a patient with phacomatosis spilosebacea (PSS) using topical sirolimus. EN is a type of birthmark, while PSS is a rare disorder characterized by the presence of EN along with other organ system involvement. Treatment of EN can be challenging, but topical sirolimus has shown promising results in managing difficult-to-treat dermatological disorders. In this case, a patient with PSS experienced a marked decrease in thickness of the EN lesions after 5 weeks of treatment with topical sirolimus, with no adverse effects reported. Further follow-up is needed to confirm the long-term improvement. [Extracted from the article]

Granuloma annulare (GA) is an entity of unknown origin classified among granulomatous skin diseases. GA diagnosis was made and treatment with cyclosporine 200 mg per day was started with only partial improvement after 10 months. TNF is known to participate in the formation and maintenance of granulomas, especially in its transmembrane form.1 Therefore, it seems logical to speculate that drugs that inhibit TNF- could prevent GA progression. [Extracted from the article]

Unilateral linear capillaritis is a rare variant of the pigmented purpuric dermatoses that can be misdiagnosed due to confusion with other cutaneous diseases that follow a linear distribution. We present the case of an 8‐year‐old boy with hyperpigmented patches linearly distributed on the right arm, initially diagnosed with segmental neurofibromatosis. [ABSTRACT FROM AUTHOR]

Granulomatous periorificial dermatitis is a clinical variant of periorificial dermatitis. We present the case of an 18‐year‐old girl with several reddish papular lesions in the perioral, perinasal, and periorbital regions unresponsive to conventional therapy. After 6 months of therapy with low‐dose oral isotretinoin, the lesions fully remitted. [ABSTRACT FROM AUTHOR]