121 results on '"Eraksoy, Haluk"'
Search Results
2. Gastrointestinal and Abdominal Tuberculosis
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Eraksoy, Haluk
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- 2021
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3. The effect of tocilizumab, anakinra and prednisolone on antibody response to SARS-CoV-2 in patients with COVID-19: A prospective cohort study with multivariate analysis of factors affecting the antibody response
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Başaran, Seniha, Şimşek-Yavuz, Serap, Meşe, Sevim, Çağatay, Atahan, Medetalibeyoğlu, Alpay, Öncül, Oral, Özsüt, Halit, Ağaçfidan, Ali, Gül, Ahmet, and Eraksoy, Haluk
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- 2021
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4. Interplay between HIV and Human Pegivirus (HPgV) Load in Co-Infected Patients: Insights from Prevalence and Genotype Analysis.
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Köksal, Muammer Osman, Pirkl, Martin, Sarsar, Kutay, Ilktaç, Mehmet, Horemheb-Rubio, Gibran, Yaman, Murat, Meşe, Sevim, Eraksoy, Haluk, Akgül, Baki, and Ağaçfidan, Ali
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HIV ,HIV infections ,VIRAL load ,GENOTYPES ,BLOOD products - Abstract
Human pegivirus (HPgV) is transmitted through sexual or parenteral exposure and is common among patients receiving blood products. HPgV is associated with lower levels of human immunodeficiency virus (HIV) RNA and better survival among HIV-infected patients. This study aimed to investigate the prevalence of HPgV and determine its subtypes in HIV-infected individuals living in Istanbul, which has the highest rate of HIV infection in Türkiye. Total RNA extraction from plasma, cDNA synthesis, and nested PCR were performed for HPgV on plasma samples taken from 351 HIV-1-infected patients. The HPgV viral load was quantified on HPgV-positive samples. HPgV genotyping was performed by sequencing the corresponding amplicons. In the present study, the overall prevalence of HPgV RNA in HIV-infected patients was 27.3%. HPgV subtypes 1, 2a, and 2b were found, with subtype 2a being the most frequent (91.6%). Statistical analysis of HIV-1 viral load on HPgV viral load showed an opposing correlation between HIV-1 and HPgV loads. In conclusion, these data show that HPgV infection is common among HIV-positive individuals in Istanbul, Türkiye. Further comprehensive studies are needed to clarify both the cellular and molecular pathways of these two infections and to provide more information on the effect of HPgV on the course of the disease in HIV-infected individuals. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Influence of multidrug resistant organisms on the outcome of diabetic foot infection
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Saltoglu, Nese, Ergonul, Onder, Tulek, Necla, Yemisen, Mucahit, Kadanali, Ayten, Karagoz, Gul, Batirel, Ayse, Ak, Oznur, Sonmezer, Cagla, Eraksoy, Haluk, Cagatay, Atahan, Surme, Serkan, Nemli, Salih A., Demirdal, Tuna, Coskun, Omer, Ozturk, Derya, Ceran, Nurgul, Pehlivanoglu, Filiz, Sengoz, Gonul, Aslan, Turan, Akkoyunlu, Yasemin, Oncul, Oral, Ay, Hakan, Mulazımoglu, Lutfiye, Erturk, Buket, Yilmaz, Fatma, Yoruk, Gulsen, Uzun, Nuray, Simsek, Funda, Yildirmak, Taner, Yaşar, Kadriye Kart, Sonmezoglu, Meral, Küçükardali, Yasar, Tuna, Nazan, Karabay, Oguz, Ozgunes, Nail, and Sargın, Fatma
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- 2018
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6. HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey
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Köksal, Muammer Osman, Beka, Hayati, Lübke, Nadine, Verheyen, Jens, Eraksoy, Haluk, Cagatay, Atahan, Kaiser, Rolf, Akgül, Baki, and Agacfidan, Ali
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- 2015
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7. HIDDEN DANGER OF SARS-COV-2; MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS (MIS-A): FIRST CASE SERIES IN A SINGLE CENTER FROM TURKIYE.
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BENLİ, Aysun, TOR, Yavuz Burak, ŞİMŞEK-YAVUZ, Serap, BAŞARAN, Seniha, ÇAĞATAY, Atahan, ÖZSÜT, Halit, GÜL, Ahmet, and ERAKSOY, Haluk
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MULTISYSTEM inflammatory syndrome ,LOW-molecular-weight heparin ,SARS-CoV-2 ,ADULTS ,PEPTIDES ,LYMPHOPENIA - Abstract
Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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8. Molecular epidemiology of HIV in a cohort of men having sex with men from Istanbul
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Alpsar, Dilek, Agacfidan, Ali, Lübke, Nadine, Verheyen, Jens, Eraksoy, Haluk, Çağatay, Atahan, Bozkaya, Emel, Kaiser, Rolf, and Akgül, Baki
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- 2013
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9. Seroprevalencia de la sífilis entre hombres infectados con el HIV en Estambul, Turquía
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Koksal, Muammer Osman, Beka, Hayati, Evlice, Oguz, Ciftci, Sevgi, Keskin, Fahriye, Basaran, Seniha, Akgül, Baki, Eraksoy, Haluk, and Agacfidan, Ali
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Hombres ,Sífilis ,Human immunodeficiency virus ,Epidemiology ,Epidemiología ,Men ,Syphilis ,Sexually transmitted disease ,Virus de la inmunodeficiencia humana ,Enfermedades de transmisión xual - Abstract
Syphilis has become a serious issue for human immunodeficiency virus (HIV)-infected patients worldwide in recent years; however, the studies related to HIV coinfection and syphilis reinfections in Istanbul, Turkey, are limited. Ourobjective was to determine the seroprevalence of syphilis among HIV-infected men in the city which has one of the highest HIV prevalence rates in Turkey. Two hundred and forty four (244) HIV-positive men were evaluated at Istanbul Medical Faculty, Department of Medical Microbiology from March to June 2018. Serum samples were screened for the presence of antibodies against Treponema pallidum using the chemilumines-cent microparticle immunoassay (CMIA). Samples found to be positive were investigated with the rapid plasma reagin (RPR) test and the T. pallidum hemagglutination assay (TPHA). The patients completed a questionnaire for sociodemographic data. The mean age was found to be 41.8 years; 35.6% were men who havesexwith men (MSM). The overall seroprevalence of syphilis among the patients was 19.3%. MSM had a significantly higher seroprevalence than heterosexual patients (28.7%). In Turkey, there is a high seroprevalence of syphilis in HIV-infected patients, MSM being the most affected group. Therefore, HIV-infected patients should be screened for syphilis at least annually and should be informed about sexually transmitted diseases (STDs). Resumen En los últimos años, la sífilis se ha convertido en un problema grave para los pacientes infectados por el virus de la inmunodeficiencia humana (HIV) en todo el mundo; sin embargo, los estudios relacionados con la coinfección por HIV y las reinfecciones por sífilis en Estambul, Turquía, son limitados. Nuestro objetivo fue determinar la seroprevalencia de la sífilis entre los hombres infectados por el HIV en Estambul, ciudad con las tasas de prevalencia del HIV más altas de Turquía. Se evaluaron 244 hombres con HIV entre marzo y junio de 2018 en la Facultad de Medicina de Estambul, Departamento de Microbiología Médica. Las muestras de suero se analizaron para detectar la presencia de anticuerpos contra Treponema pallidum con un inmunoensayo de micropartículas quimioluminiscentes (CMIA). Las muestras que resultaron positivas en dicha prueba se investigaron con la prueba de reagina plasmática rápida (RPR) y el ensayo de hemoaglutinación T. pallidum (TPHA). Los pacientes completaron un cuestionario de datos sociodemográficos. La media de la edad fue de 41,8 anos; 35,6% eran hombres que tienen sexo con hombres (HSH). La seroprevalencia global de sífilis entre los pacientes fue del 19,3%. Los HSH tuvieron una seroprevalencia significativamente mayor que los pacientes heterosexuales (28,7%). En Turquía, existe una alta seroprevalencia de la sífilis en pacientes infectados por el HIV y los HSH son el grupo más afectado. Por lo tanto, los pacientes infectados por el HIV deben someterse a la detección de sífilis al menos una vez al año y deben ser informados sobre las enfermedades de transmisión sexual (ETS).
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- 2020
10. Comparison of the Clinical and Laboratory Findings and Outcomes of Hospitalized COVID-19 Patients Who Were Either Fully Vaccinated with Coronavac or Not: An Analytical, Cross Sectional Study.
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Yavuz, Serap Şimşek, Tunçer, Gülşah, Altuntaş-Aydın, Özlem, Aydın, Mehtap, Pehlivanoğlu, Filiz, Tok, Yeşim, Mese, Sevim, Gündüz, Alper, Güçlü, Ceyda Geyiktepe, Özdoğan, İklima, Hemiş-Aydın, Börçe, Soğuksu, Pınar, Benli, Aysun, Başaran, Seniha, Midilli, Kenan, and Eraksoy, Haluk
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VACCINATION status ,COVID-19 ,HOSPITAL patients ,BREAKTHROUGH infections ,COVID-19 vaccines - Abstract
COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fully vaccinated with Coronovac or not. All hospitalized COVID-19 patients who had at least one dose of Coronavac were included in the study. The oldest unvaccinated patients with comorbidities, who were hospitalized during the same period, were chosen as controls. All epidemiologic, clinical and laboratory data of the patients were recorded and compared between the fully vaccinated and unvaccinated individuals. There were 69 and 217 patients who had been either fully vaccinated with Coronavac or not, respectively. All breakthrough infections occurred in the first 3 months of vaccination. Fully vaccinated patients were older and had more comorbidities than unvaccinated patients. There were minor differences between the groups in symptoms, physical and laboratory findings, anti-spike IgG positivity rate and level, the severity of COVID-19, complications, and clinical improvement rate. The mortality rate of fully vaccinated patients was higher than the mortality rate in unvaccinated patients in univariate analysis, which was attributed to the fact that vaccinated patients were older and had more comorbidities. The severity and clinical outcomes of hospitalized patients with breakthrough COVID-19 after Coronavac vaccination were similar to those of unvaccinated patients. Our findings suggest that the immune response elicited by Coronovac could be insufficient to prevent COVID-19-related severe disease and death within 3 months of vaccination among elderly people with comorbidities. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Intrathecal Colistin Induced Chemical Meningitis in a Case of Multi-drug Resistant Acinetobacter baumannii Meningitis.
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Benli, Aysun, Şimşek-Yavuz, Serap, and Eraksoy, Haluk
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- 2022
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12. Comparative activity of carbapenem testing: the COMPACT study
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Nordmann, Patrice, Picazo, Juan J., Mutters, Reinier, Korten, Volkan, Quintana, Alvaro, Laeuffer, Joerg M., Seak, Joyce Chen Hian, Flamm, Robert K., Morrissey, Ian, Azadian, Berge, El-Bouri, Khalid, Jones, Graeme, Masterton, Bob, Morgan, Marina, Oppenheim, Beryl, Waghorn, David, Smyth, Edmond, Abele-Horn, Marianne, Jacobs, Enno, Mai, Uwe, Mutters, Reinier, Pfister, Wolfgang, Schoerner, Christoph, Seifert, Harald, Bebear, Cécile, Bingen, Edouard, Bonnet, Richard, Jehl, François, Levy, Pierre-Yves, Nordmann, Patrice, Delvallez, Micheline Roussel, Paniara, Olga, Papaparaskevas, Joseph, Piotr, Heczko, Kolář, Milan, Žemličková, Helena, Hanzen, Juraj, Kotulová, Daniela, Campa, Mario, Fadda, Giovanni, Fortina, Giacomo, Gesu, Giovanni, Manso, Esther, Milano, Fulvia, Nicoletti, Giuseppe, Pucillo, Leopoldo, Rigoli, Roberto, Rossolini, Gianmaria, Sambri, Vittorio, Sarti, Mario, Akaln, Halis, Snrtaş, Melda, Akova, Murat, Hasçelik, Gülşen, Arman, Dilek, Dizbay, Murat, Aygen, Bilgehan, Sümerkan, Bülent, Dokuzoğuz, Başak, Esener, Harika, Eraksoy, Haluk, Başaran, Seniha, Köksal, İftihar, Bayramoğlu, Gülçin, Korten, Volkan, Söyletir, Güner, Ulusoy, Sercan, Tünger, Alper, Yalçn, Ata Nevzat, Öğünç, Dilara, Bou, Germán, Bouza, Emilio, Canton, Rafael, Coll, Pere, García-Rodriguez, José Ángel, Gimeno, Concepción, Gobernado, Miguel, Bertomeu, Frederic Gomez, Gómez-Garcés, José Luis, Marco, Francesc, Martínez-Martínez, Luis, Pascual, Alvaro, Pérez, José Luis, Picazo, Juan, Prats, Guillem, Linares, Maria Saumoy, Ghaly, Farid, Cristino, Melo, Diogo, Jose, Ramos, Helena, Balode, Arta, Jürna-Ellam, Marika, and Koslov, Roman
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- 2011
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13. STAPHYLOCOCCUS AUREUS BAKTERİYEMİLERİNDE MORTALİTE RİSK FAKTÖRLERİNİN ANALİZİ: SEFAZOLİN DAHA İYİ SONUÇLA İLİŞKİLİ
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BAŞARAN, Seniha, ŞİMŞEK YAVUZ, Serap, SADIÇ ÇOPUR, Betül, YİR, Asiye, ÇAĞATAY, Atahan, ÖNCÜL, Oral, ÖZSÜT, Halit, and ERAKSOY, Haluk
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Methicillin-sensitive Staphylococcus aureus,healthcare associated bacteraemia,cefazolin ,Health Care Sciences and Services ,Metisiline duyarlı Staphylococcus aureus,sağlık bakımı ile ilişkili bakteriyemi,sefazolin ,Sağlık Bilimleri ve Hizmetleri - Abstract
Objective: Methicillin-sensitive Staphylococcus aureus (MSSA) is frequent cause of bacteraemias and associated with substantial mortality. We defined risk factors for mortality among patients with either community-acquired (CA) or healthcare-associated (HCA) MSSA bacteraemia with special emphasis on treatment options including cefazolin and other antimicrobials (mainly ampicillin-sulbactam). Material and Method: All adult patients who were hospitalized and whose blood cultures were positive for MSSA between 2009 and 2014 were included. Patients with CA and HCA MSSA bacteraemia were compared. Results: 83% of the 127 patients with MSSA bacteraemia had HCA. The mortality rate of patients was 20.5% and this did not differ between patients with either CA or HCA MSSA bacteraemia. In the multivariate analysis, higher comorbidity index (HR 1.557), presence of metastatic foci (HR 2.883), and requirement for ICU support (HR 16.239) were found as independent risk factors for mortality, and cefazolin use was found to be protective against mortality (HR 0.178). Conclusion: Patients with MSSA bacteraemia should be treated with cefazolin instead of other antimicrobial options, especially in countries where anti-staphylococcal penicillins are not available or in patients who cannot tolerate anti-staphylococcal penicillins, as cefazolin was found to be protective against mortality, Amaç: Metisiline duyarlı Staphylococcus aureus (MSSA), önemli bir bakteriyemi etkeni olup, hastalarda ciddi mortaliteye neden olur. Bu çalışmada, toplum kaynaklı (TK) veya sağlık bakımı (SB)’yla ilişkili MSSA bakteriyemilerinde mortaliteye etki eden risk faktörlerinin belirlenmesi amaçlanmıştır. Ayrıca MSSA bakteriyemilerinin tedavi seçeneklerinden sefazolin ve özellikle ampisilin-sulbaktam olmak üzere diğer antimikrobiklerin tedavideki yeterlikleri karşılaştıırlmıştır. Gereç ve Yöntem: 2009-2014 yılları arasında hastanemizde yatarak tedavi edilen ve MSSA bakteriyemisi tanısı konulan erişkin hastalar çalışmaya dahil edildi. TK veya SB ilişkili MSSA bakteriyemisi olan hastalar karşılaştırıldı. Bulgular: Toplam 127 MSSA bakteriyemili hastanın %83’ü SB ile ilişkiliydi. Mortalite oranı %20,5 olup, TK ve SB MSSA bakteriyemili hastalar arasında fark yoktu. Çok değişkenli analizde yüksek komorbidite indeksi (HR 1,557), metastatik infeksiyon odağı varlığı (HR 2,883) ve yoğun bakım desteğine ihtiyacın olması (HR 16,239) mortalite için bağımsız risk faktörleri, tedavide sefazolin kullanımı ise mortaliteyi azaltan bir faktör olarak saptandı (HR 0,178). Sonuç: Diğer antimikrobiyallerle karşılaştırıldığında sefazolinle tedavi edilen MSSA bakteriyemilerinde klinik sonuçlar daha iyi belirlendiği için, özellikle antistafilokoksik penisilinlerin bulunmadığı yerlerde veya bu ajanları tolere edemeyen hastalarda diğer antimikrobiklerin yerine sefazolin tercih edilmelidir.
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- 2019
14. Haemophagocytosis in a patient with Crimean–Congo haemorrhagic fever
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Cagatay, Atahan, Kapmaz, Mahir, Karadeniz, Asli, Basaran, Seniha, Yenerel, Mustafa, Yavuz, Selim, Midilli, Kenan, Ozsut, Halit, Eraksoy, Haluk, and Calangu, Semra
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- 2007
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15. The Impact of C Reactive Protein in Prediction of the Outcome in Infective Endocarditis.
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Şimşek-Yavuz, Serap, Doğan-Kaya, Sibel, Deniz, Denef, Tükenmez-Tigen, Elif, Öztürk, Serpil, Menekşe, Şirin, Öcalmaz, Mutlu Şeyda, Başaran, Seniha, Şensoy, Ayfer, Uygun-Kızmaz, Yeşim, Yılmaz, Ezgi, and Eraksoy, Haluk
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- 2021
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16. Extrapulmonary Tuberculosis in Immunocompetent Adults
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Cagatay, ARIF ATAHAN, Caliskan, YASAR, Aksoz, SELCUK, Gulec, LEYLA, Kucukoglu, SEHIHA, Cagatay, YONCA, Berk, HANDE, Ozsut, HALIT, Eraksoy, HALUK, and Calangu, SEMRA
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- 2004
17. Transmission route and reasons for HIV testing among recently diagnosed HIV patients in HIV‐TR cohort, 2011–2012
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Dokuzoguz, Basak, Korten, Volkan, Gökengin, Deniz, Fincanci, Muzaffer, Yildirmak, Taner, Kes, Uzun Nuray, Fisgin, Nuriye Tasdelen, Inan, Dilara, Eraksoy, Haluk, and Akalin, Halis
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HIV testing -- Usage -- Surveys ,Disease transmission -- Surveys -- Methods ,HIV patients -- Surveys ,Health - Abstract
Introduction: Routes of transmission and reasons for HIV testing are important epidemiologic data to analyze the epidemic and to tailor the response to AIDS. The aim of this study was to analyze reasons for testing and transmission ways of HIV among recently diagnosed HIV patients registered in the multicenter HIV‐TR cohort in Turkey. Methods: Transmission ways and reasons for testing of all patients diagnosed in 2011 and 2012 were recorded on a web‐based data collection system and were analyzed retrospectively. Results: The study included 693 patients (561 male, 132 female) from 24 sites. Reason for HIV testing was available in 640 patients (92%). The most common reason for HIV testing was diagnostic workout for other conditions or illness followed by patient‐initiated testing. The reasons for testing were listed in Table 1. The most common routes of HIV transmission were heterosexual intercourse (62.7%) and sex among men who have sex with men (MSM) (22.6%). At the time of HIV diagnosis, the mean CD4 lymphocyte cell count was 355/mm[sup.3] (3–1433/mm[sup.3]). Primary HIV infection was determined in 42/693 (6%) patients and 9/693 (% 1, 2) cases were considered “probable primary HIV infection.” The majority of the cases presented to a clinic for follow‐up right after the diagnosis. On the other hand 32/616 (5.2%) patients delayed their presentation for more than 3 months. The longest delay was 11 months. Conclusions: The results of the database suggest that targeted testing is lacking in the country. The shift toward homosexual transmission during the last 2 years emphasizes the need for targeted interventions. Patients present relatively late and HIV infection could only be diagnosed when immunosuppression related findings appeared. Patient‐initiated testing,an indicator of awareness, was very low suggesting a need to scale‐up awareness raising interventions., Table 1: Reasons for HIV testing Reason for testing N % Blood/organ donation 63 9.8 Prior to surgical/parenteral intervention 63 9.8 Premarital testing 20 3.1 Screening for pregnancy 11 1.7 [...]
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- 2014
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18. Immunization of renal transplant recipients with pneumococcal polysaccharide vaccine
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Kazancioğlu, Rümeyza, Sever, Mehmet Ş, Yüksel-Önel, Derya, Eraksoy, Haluk, Yildiz, Alaattin, Çelik, A Vedat, Kayacan, Seyit M, and Badur, Selim
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- 2000
19. Trends and factors associated with modification or discontinuation of the initial antiretroviral regimen during the first year of treatment in the Turkish HIV-TR Cohort, 2011–2017.
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Korten, Volkan, Gökengin, Deniz, Eren, Gülhan, Yıldırmak, Taner, Gencer, Serap, Eraksoy, Haluk, Inan, Dilara, Kaptan, Figen, Dokuzoğuz, Başak, Karaoğlan, Ilkay, Willke, Ayşe, Gönen, Mehmet, and Ergönül, Önder
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CONFIDENCE intervals ,DATABASES ,DRUG toxicity ,HIV infections ,LONGITUDINAL method ,MATHEMATICAL models ,PATIENT compliance ,REGRESSION analysis ,RISK assessment ,RNA ,THEORY ,PROTEASE inhibitors ,ANTIRETROVIRAL agents ,TERMINATION of treatment ,PROPORTIONAL hazards models ,HIV integrase inhibitors ,NON-nucleoside reverse transcriptase inhibitors ,PATIENTS' attitudes ,DESCRIPTIVE statistics - Abstract
Background: There is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART before and after the availability of better tolerated and less complex regimens by comparing the frequency, reasons and associations with patient characteristics. Methods: A total of 3019 ART-naive patients registered in the HIV-TR cohort who started ART between Jan 2011 and Feb 2017 were studied. Only the first modification within the first year of treatment for each patient was included in the analyses. Reasons were classified as listed in the coded form in the web-based database. Cumulative incidences were analysed using competing risk function and factors associated with discontinuation of the ART regimen were examined using Cox proportional hazards models and Fine-Gray competing risk regression models. Results: The initial ART regimen was discontinued in 351 out of 3019 eligible patients (11.6%) within the first year. The main reason for discontinuation was intolerance/toxicity (45.0%), followed by treatment simplification (9.7%), patient willingness (7.4%), poor compliance (7.1%), prevention of future toxicities (6.0%), virologic failure (5.4%), and provider preference (5.4%). Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based (aHR = 4.4, [95% CI 3.0–6.4]; p < 0.0001) or protease inhibitor (PI)-based regimens (aHR = 4.3, [95% CI 3.1–6.0]; p < 0.0001) relative to integrase strand transfer inhibitor (InSTI)-based regimens were significantly associated with ART discontinuation. ART initiated at a later period (2015-Feb 2017) (aHR = 0.6, [95% CI 0.4–0.9]; p < 0.0001) was less likely to be discontinued. A lower rate of treatment discontinuation for intolerance/toxicity was observed with InSTI-based regimens (2.0%) than with NNRTI- (6.6%) and PI-based regimens (7.5%) (p < 0.001). The percentage of patients who achieved HIV RNA < 200 copies/mL within 12 months of ART initiation was 91% in the ART discontinued group vs. 94% in the continued group (p > 0.05). Conclusion: ART discontinuation due to intolerance/toxicity and virologic failure decreased over time. InSTI-based regimens were less likely to be discontinued than PI- and NNRTI-based ART. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Dio-sensimedia: a novel culture medium for rapid detection of extended spectrum β-lactamases
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Eraksoy Haluk, Kocagoz Tanil, and Cagatay Atahan
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Resistance to contemporary broad-spectrum β-lactams, mediated by extended-spectrum β-lactamases (ESBL), is an increasing problem worldwide. Many of the emerging antimicrobial resistance problems of this decade have been characterized by difficulty in the recognition of resistance in the laboratory, particularly by rapid susceptibility test methods. The plasmid-encoded ESBL represent such a resistance phenomenon that is difficult to recognize. We compared Dio-Sensimedia-ES (DSM-ES; Diomed, Istanbul, Turkey) and Mueller-Hinton (MH) agar in the double-disk synergy test (DDST) as a novel rapid system for detecting ESBL directly from bacterial culture. Methods Sixty ESBL-producing Klebsiella pneumoniae isolates cultured from blood (30), endotracheal aspirates (20), urine (5) and pus (5), as well as 40 Escherichia coli isolates cultured from endotracheal aspirates (15), urine (10), blood (8) and pus (7) were studied. Isolates positive for ESBL by the combined disk tests were tested with the DDST using MH and DSM-ES agar to detect ESBL-mediated resistance in K. pneumoniae and E. coli. DSM-ES agar was also used to determine the susceptibility of Enterobacteriaceae and staphylococci. Results Among 60 ESBL-producing K. pneumoniae isolates, 59 (98.3%) were identified as ESBL-positive by the DDST using MH, and 58 (96.6%), using DSM-ES agar. Of 40 ESBL-producing E. coli isolates, 38 (95%) were ESBL-positive by the DDST on MH agar, and 37 (92.5%), on DSM-ES agar. The average incubation period required for ESBL detection by the DDST on DSM-ES agar was 4 hours. Conclusions Since the DDST results were available within 4 hours when DSM-ES agar was used, the use of this media may significantly lower the length of hospital stay, the total cost for patient care and even the mortality rate by fascilitating early treatment against ESBL-producing organisms.
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- 2003
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21. Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics
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Eraksoy Haluk, Çakar Nahit, Ay Pinar, Yildirim Ayşe, Özsüt Halit, Öncü Serkan, and Çalangu Semra
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Central venous catheter ,infection ,risk ,glycopeptide ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Backround We undertook a prospective study of all new central venous catheters inserted into patients in the intensive care units, in order to identify the risk factors and to determine the effect of glycopeptide antibiotics on catheter – related infections. Methods During the study period 300 patients with central venous catheters were prospectively studied. The catheters used were nontunneled, noncuffed, triple lumen and made of polyurethane material. Catheters were cultured by semiquantitative method and blood cultures done when indicated. Data were obtained on patient age, gender, unit, primary diagnosis on admission, catheter insertion site, duration of catheterization, whether it was the first or a subsequent catheter and glycopeptide antibiotic usage. Results Ninety-one (30.3%) of the catheters were colonized and infection was found with 50 (16.7%) catheters. Infection was diagnosed with higher rate in catheters inserted via jugular vein in comparison with subclavian vein (95% CI: 1.32–4.81, p = 0.005). The incidence of infection was higher in catheters which were kept in place for more than seven days (95% CI 1.05–3.87, p = 0.03). The incidence of infection was lower in patients who were using glycopeptide antibiotic during catheterization (95% CI: 1.49–5.51, p = 0.005). The rate of infection with Gram positive cocci was significantly lower in glycopeptide antibiotic using patients (p = 0.01). The most commonly isolated organism was Staphylococcus aureus (n = 52, 37.1%). Conclusion Duration of catheterization and catheter insertion site were independent risk factors for catheter related infection. Use of glycopeptide antibiotic during catheterization seems to have protective effect against catheter related infection.
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- 2003
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22. Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report
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Özsüt Halit H, Yildirmak Taner T, Çalangu Semra S, Öncü Serkan S, Çagatay Atahan A, and Eraksoy Haluk H
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. Case Presentation A 31-year-old diabetic man presented to the outpatient clinic with the following signs and symptoms: headache, periorbital pain, swelling and loss of vision in the right eye. On physical examination his right eye was red and swollen. There was periorbital cellulitis and the conjunctiva was edematous. KOH preparation of purulent discharge showed broad, ribbonlike, aseptate hyphae when examined under a fluorescence microscope. Cranial MRI showed involvement of the right orbit, thrombosis in cavernous sinus and infiltrates at ethmoid and maxillary sinuses. Mucormycosis was diagnosed based on these findings. Amphotericin B (AmBisome®; 2 mg/kg.d) was initiated after the test doses. Right orbitectomy and right partial maxillectomy were performed; the lesions in ethmoid and maxillary sinuses were removed. The duration of the liposomal amphotericin B therapy was approximately 6 months and the total dose of liposomal amphotericin B used was 32 grams. Liposomal amphotericin B therapy was stopped six months later and oral fluconazole was started. Conclusions Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone.
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- 2001
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23. First Report of SARS-CoV-2 Gamma Variant in Turkey.
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Kuşkucu, Mert Ahmet, Tok, Yeşim Tuyji, Nohut, Okan Kadir, Abullayeva, Zarifa, Yücebağ, Ebru, Can, Füsun, Yavuz, Serap Şimşek, Eraksoy, Haluk, and Kenan Midilli
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- 2021
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24. ANALYSIS OF RISK FACTORS FOR MORTALITY IN METHICILLINSENSITIVE STAPHYLOCOCCUS AUREUS BACTERAEMIA: CEFAZOLIN IS ASSOCIATED WITH BETTER OUTCOME.
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BAŞARAN, Seniha, YAVUZ, Serap ŞİMŞEK, ÇOPUR, Betül SADIÇ, YİR, Asiye, ÇAĞATAY, Atahan, ÖNCÜL, Oral, ÖZSÜT, Halit, and ERAKSOY, Haluk
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STAPHYLOCOCCUS aureus ,BACTEREMIA ,CEFAZOLIN ,MORTALITY ,RISK assessment ,BACTEREMIA treatment - Abstract
Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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25. Hyponatremia Is Predictive of HSV-1 Encephalitis among Patients with Viral Encephalitis.
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Basaran, Seniha, Yavuz, Serap Simsek, Bali, Elif Aguloglu, Cagatay, Atahan, Oncul, Oral, Ozsut, Halit, and Eraksoy, Haluk
- Abstract
Encephalitis is an inflammatory process involving the brain parenchyma associated with neurologic dysfunction. The main causes of infectious encephalitis are viruses, including Herpes simplex virus type 1 (HSV-1). As the mortality rate of HSV-1 encephalitis could be reduced with early acyclovir treatment, it is imperative to distinguish HSV-1 encephalitis from other type of viral encephalitis as early as possible. However, sophisticated methods for definitive diagnosis of HSV-1 encephalitis are not readily available. We aimed to explore distinctive clinical and laboratory features of HSV-1 encephalitis. All of the adult patients with viral encephalitis hospitalized between 2011-2017 were enrolled, including 16 patients with HSV-1 encephalitis and 51 patients non-HSV-1 viral encephalitis. Determination of viruses in cerebrospinal fluid was performed by PCR tests. Female sex, hyponatremia, and abnormalities in MRI were independently associated with HSV-1 encephalitis (p < 0.05 for each). In particular, hyponatremia (< 135 mEq/L) was found in nine patients with HSV-1 encephalitis (56.3%) and 10 patients with non-HSV-1 viral encephalitis (19.6%) (p = 0.005). As serum sodium is determined easily and quickly in clinical practice, the presence of hyponatremia among patients with viral encephalitis could be helpful for the early diagnosis of HSV-1 encephalitis before cerebrospinal fluid PCR results were available. Moreover, the presence of positive finding in MRI could further support the diagnosis. This is the first study that compared the serum sodium levels among patients between HSV-1 and non-HSV-1 viral encephalitis. We thus propose the diagnostic value of hyponatremia for HSV-1 encephalitis. [ABSTRACT FROM AUTHOR]
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- 2019
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26. Hematologic Adverse Effects of Prolonged Piperacillin- Tazobactam Use in Adults.
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Benli, Aysun, Şimşek-Yavuz, Serap, Başaran, Seniha, Çağatay, Atahan, Özsüt, Halit, and Eraksoy, Haluk
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ANTIBIOTICS ,LEUCOPENIA ,NEUTROPENIA ,EOSINOPHILIA ,ALLERGIES ,BLOOD diseases ,COMBINATION drug therapy ,ENZYME inhibitors ,DISEASE incidence ,AMPICILLIN ,LEUKOCYTE count ,ADULTS ,DISEASE risk factors - Abstract
Copyright of Turkish Journal of Hematology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
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27. Ortopedi ve travmatoloji kliniğindeki nozokomiyal infeksiyon etkenleri ve antibiyotiklere duyarlıkları
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PUNAR, Metin, OZSUT, Halit, ERAKSOY, Haluk, DİLMENER, Murat, and CALANGU, Semra
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Orthopedics and Traumatology ,nosocomial infection - Abstract
During the period of 1 st April 1993 and 31st December 1993, we isolated 150 bacteria species from 113 aerobic cultures of 86 patients with nosocomial infections, as CDC defined, in Orthopedics and TraumatoIogy Department of our Faculty. Antibiotic susceptibility, patterns of the isolated bacteria were investigated with disc diffusion test. Among the isolates are 19% Pseudomonas aeruginosa, 13% other nonfermentative Gramnegative rods, 17% Klebsiella pneumoniae, 7% other Gram-negative enteric rods; 33% Staphylococcus aureus, 10% coagulase-negative staphylococci and 1 % Gram-pozitive rods. AII of the isolated Gram-negative rods were found to be sensitive to imipenem; other than imipenem the most active antibiotics are cefoperazone/sulbactam, aztroenam, amikacin, ceftazidime, piperacillin and ciprofloxacin for P. aeruginosa; netilmisin (%68), amikacin (63%) and cefoperazone/sulbactam (63%) for other nonfermentative Gram-negative rods; amikacin (69%) and ciprofloxacin (65%) . 69% of the isolated S. aureus species and 60% of coagulase-negative staphylococci were found to be methicillin-resistant. These data reveals once more that antibiotic susceptibility patterns are required for choosing antibiotics in the treatment of nosocomial infections in Orthopedics and Traumatology Department of our Faculty., 1 Nisan - 31 Aralık 1993 tarihleri arasında Fakültemiz Ortopedi ve Travmatoloji Kliniği'nde yatmakta olan ve CDC tanımına göre nozokomiyal infeksiyonu olduğuna karar verilen 86 hastanın toplam 113 aerop kültür örneğinden 150 bakteri suşu izole edildi. izole edilen bakterilerin antibiyotik duyarlık testleri disk difüzyon yöntemiyle yapıldı. Suşların % 19'u Pseudomonas aeruginosa, % 13'ü diğer nonfermentatif Gram-negatif çomakIar, % 17'si Klebsiella pneumoniae, %7'si diğer Gram-negatif enterik çomaklar; %33'ü Staphylococcus aureus, % 1 O'u koagülaz-negatif stafilokoklar ve % 1'i Gram-pozitif çomaklar idi. İzole edilen Gram-negatif çomakların tümünün duyarlı olduğu imipenem'den sonra en etkili antibiyotikler P.aeruginosa için sefoperazon/sulbaktam, aztreonam, amikasin, seftazidim, piperasilin ve siprofloksasin; diğer nonfermentatif Gram-negatif çomaklar için netilmisin (%68), amikasin (%63) ve sefoperazon/sulbaktam (%63); K.pneumoniae için ise amikasin (%69) ve siprofloksasin (%65) idi. S.aureus suşlarının %69'u; koagülaz-negatif stafilokoklann ise %60'ı metisiIine dirençli bulundu. Bu veriler, Fakültemiz Ortopedi ve Travmatoloji Kliniği'ndeki nozokomiyal infeksiyonlanmn tedavisinde kullanılacak antibiyotiklerin seçiminde antibiyotik duyarlık testlerinin kılavuzluğuna gereksinim olduğunu bir kez daha göstermektedir.
- Published
- 2014
28. Comparative evaluation of in vitro activities of carbapenemes against gram-negative pathogens: Turkish data of COMPACT study
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Korten, Volkan, Söyletir, Güner, Yalçın, Ata Nevzat, Oğünç, Dilara, Dokuzoğuz, Başak, Esener, Harika, Ulusoy, Sercan, Tünger, Alper, Aygen, Bilgehan, Sümerkan, Bülent, Arman, Dilek, Dizbay, Murat, Akova, Murat, Hasçelik, Gülşen, Eraksoy, Haluk, Başaran, Seniha, Köksal, İftihar, Bayramoğlu, Gülçin, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Akalın, Halis, and Sinirtaş, Melda
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Ertapenem ,Tebipenem ,Anti-Bacterial Agents ,Declining sensitivities ,Turkey ,Antibiotic resistance ,Gram-negative bacterial infections ,Bacteremia ,Gram negative bacterium ,Microbial sensitivity tests ,Infections ,Bacilli ,Microbiology ,Article ,Turkey (republic) ,Gram-negative pathogen ,Cross infection ,Anti-bacterial agents ,In vitro activity ,Humans ,Karbapenem ,Intensive care unit ,Carbapenem ,Antiinfective agent ,Drug resistance, bacterial ,Intensive care units ,Doripenem ,Mutants ,Meropenem ,Carbapenem derivative ,Dire consequences ,Daunting challenges ,Multicenter study ,Bacterial pneumonia ,Clinical trial ,Drug effect ,Imipenem ,Carbapenems ,Gram-negative bacteria ,Gram negative infection ,Gram-negatif patojen ,Pneumonia, bacterial ,Thienamycins ,Microbiological examination ,In vitro aktivite ,Comparative study ,Thienamycin derivative ,Antibiotic-resistance ,Human - Abstract
Bu çalışmada, doripenem, imipenem ve meropenemin gram-negatif klinik izolatlara karşı in vitro aktivitesinin değerlendirilmesi amaçlanmıştır. Türkiye genelinde toplam 10 merkezden Eylül-Aralık 2008 tarihleri arasında, yoğun bakım ünitesi (YBÜ) ve YBÜ dışı hastalardan, toplam 596 adet klinik izolat toplanmıştır. Bunlardan %42.4’ü nozokomiyal pnömoni, %40.4’ü kan dolaşımı enfeksiyonu ve %17.1’i komplike intraabdominal enfeksiyon kaynaklı olup; %51.8’i YBÜ hastalarından alınmıştır. İzolatların %49.8’i Pseudomonas spp., %40.3’ü Enterobacteriaceae ve %9.9’u diğer gram-negatif etkenlerden oluşmaktadır. Her merkezde Etest® (AB Biodisk, Solna, İsveç) kullanılarak tüm izolatlar için doripenem, imipenem ve meropenemin minimum inhibitör konsantrasyonu (MİK) belirlenmiştir. İzolatlardan 188 (%31.5)’i en az bir karbapeneme dirençli bulunmuştur. Pseudomonas türlerine karşı doripenem için MİK50 değerleri meropeneme benzer olarak 1 mg/L bulunurken, imipenemden iki kat daha düşük olduğu izlenmiştir. Pseudomonas aeruginosa izolatlarının duyarlılıkları, doripenem için MİK 2 mg/L düzeyinde %64, imipenem ve meropenem için MİK 4 mg/L düzeyinde sırasıyla %53.9 ve %63 olarak tespit edilmiştir. Doripenem ve meropenem, Enterobacteriaceae türlerine karşı benzer aktivite gösterirken (MİK90 0.12 mg/L), imipenem dört kat daha az aktif (0.5 mg/L) bulunmuştur. Büyük çoğunluğunu Acinetobacter türlerinin oluşturduğu diğer gram-negatif basiller için doripenem MİK50 değeri 8 mg/L, diğer iki ilaç için ise 32 mg/L’dir. P.aeruginosa izolatları 8 mg/L MİK düzeyinde doripenem ile %84.2, meropenem ile %72.1 oranında inhibe olmuştur. Sonuç olarak doripenem, bu çalışmada toplanan patojenlere karşı genel olarak meropenem ile benzer ya da daha iyi; imipenemden ise belirgin olarak daha iyi in vitro aktiviteye sahiptir. Üç karbapenem arasında Pseudomonas türlerine karşı en aktif olan ilacın doripenem olduğu görülmüştür. Doripenem ve meropenem Enterobacteriaceae türlerine karşı benzer aktiviteye sahip olup, imipenemden en az dört kat daha aktiftir. Bu bulgular ışığında, hastanede YBÜ’de ya da YBÜ dışında tedavi gören nozokomiyal pnömoni, kan dolaşımı enfeksiyonu ve intraabdominal enfeksiyonu olan hastalar ile antibiyotik direnci gelişim riski olan hastaların antimikrobiyal tedavisinde doripenemin öne çıkan yeni bir antibiyotik olduğu kanısına varılmıştır. The aim of this study was to determine the in vitro activities of doripenem, imipenem, and meropenem against clinical gram-negative isolates. A total of 596 clinical isolates were obtained from intensive care unit (ICU) and non-ICU patients in 10 centers over Turkey between September-December 2008. The origin of the isolates was patients with nosocomial pneumonia (42.4%), bloodstream infections (%40.4), and complicated intraabdominal infections (17.1%). Of the isolates, 51.8% were obtained from ICU patients. The study isolates consisted of Pseudomonas spp. in 49.8%, Enterobacteriaceae in 40.3%, and other gram-negative agents in 9.9%. The minimum inhibitory concentrations (MIC) for doripenem, imipenem and meropenem were determined for all isolates in each center using Etest (R) strips (AB Biodisk, Solna, Sweden). Of the isolates, 188 (31.5%) were resistant to at least one of the carbapenems. MIC(50) of doripenem against Pseudomonas spp. was 1 mg/L which was similar to that of meropenem and two-fold lower than imipenem. Susceptibility to carbapenems in P.aeruginosa was 64% for doripenem at an MIC level of 2 mg/L, 53.9% and 63% for imipenem and meropenem at an MIC level of 4 mg/L, respectively. Doripenem and meropenem showed similar activity with the MIC(90) of 0.12 mg/L whereas imipenem was four-fold less active at 0.5 mg/L. Against other gram-negative pathogens, mostly Acinetobacter spp., MIC(50) was 8 mg/L for doripenem and 32 mg/L for other two carbapenems. P.aeruginosa isolates were inhibited 84.2% with doripenem and 72.1% with meropenem at the MIC level of 8 mg/L. Doripenem generally showed similar or slightly better activity than meropenem and better activity than imipenem against pathogens collected in this study. Against Pseudomonas spp., doripenem was the most active of the three carbapenems. Doripenem and meropenem were equally active against Enterobacteriaceae and at least four-fold more active than imipenem. It was concluded that doripenem seemed to be a promising agent in the treatment of nosocomial pneumonia, blood stream infections and intraabdominal infections particularly in patients who were under risk of developing antimicrobial resistance.
- Published
- 2011
29. Hearing loss in patient with neurobrucellosis
- Author
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Cagatay, Atahan, Karadeniz, Asli, Ozsut, Halit, Eraksoy, Haluk, and Calangu, Semra
- Subjects
Health - Abstract
To the Editor: Brucellosis is a multi-systemic infection that can affect any organ system in the body. Neurobrucellosis is an uncommon, but serious complication of brucellosis. It occurs in less [...]
- Published
- 2006
30. A case of acute hepatitis due to brucellosis
- Author
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Sunmez, Sule, Cagatay, Atahan, Karadeniz, Asli, Ozsut, Halit, Eraksoy, Haluk, and Calangu, Semra
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Brucellosis -- Research -- Case studies ,Health ,Research ,Case studies - Abstract
To the Editor: Brucellosis is a multisystemic infection that can affect any organ system in the body as well as the liver. Hepatic involvement in brucellosis is not rare and [...]
- Published
- 2006
31. An unusual association of cutis verticis gyrata with empty sella
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Sen, Fatma, Cagatay, Atahan, Ozsut, Halit, Calangu, Semra, Eraksoy, Haluk, and Ozbey, Nese
- Published
- 2008
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32. Evaluation of the Bacterial Etiologies of Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation
- Author
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Hizmali, Lokman, Tapan, Umit, and Eraksoy, Haluk
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- 2014
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33. The first case of chronic Q fever endocarditis and aortitis from Turkey: A 5-year infection before diagnosis with drain in sternum.
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Yavuz, Serap Şimşek, Özbek, Ezgi, Başaran, Seniha, Çelebi, Bekir, Yılmaz, Ebru, Başaran, Murat, Umman, Berrin, and Eraksoy, Haluk
- Subjects
Q fever ,RICKETTSIAL diseases ,AORTITIS ,AORTIC diseases - Abstract
The article presents a case study on the first case of chronic Q fever endocarditis and aortitis in Turkey. It cites the case of a 29-year-old woman who was admitted to the hospital with fever, weakness, and rash on her legs. It also mentions the examination of the patient that lead to her diagnosis of Q fever endocarditis.
- Published
- 2016
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34. Is eosinophilic gastroenteritis a primary disease or a secondary developing entity due to parasitosis?
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Kocabay, Gonenc, Gul, Emine, Cagatay, Atahan, Ozsut, Halit, Eraksoy, Haluk, Calangu, Semra, and Yilmaz, Yakut Akyon
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Health - Abstract
To the Editor: Eosinophilic gastroenteritis (EGE) is a rare condition characterized by eosinophilic infiltration of the gastrointestinal tract. (1,2) We report a patient with eosinophilic gastroenteritis, who was admitted to [...]
- Published
- 2006
35. Risk Factors for Mortality of Nosocomial Bacteraemia in Intensive Care Units.
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Çağatay, A. Atahan, Özcan, Perihan Ergin, Gulec, Leyla, Ince, Nurhan, Tugrul, Simru, Özsüt, Halit, Cakar, Nahit, Esen, Figen, Eraksoy, Haluk, and Calangu, Semra
- Subjects
CRITICAL care medicine ,INTENSIVE care units ,BACTEREMIA ,BACTERIAL diseases ,MORTALITY ,NOSOCOMIAL infections - Abstract
Objective: The aim of this study was to follow critically ill patients prospectively in intensive care units (ICUs) to determine risk factors for mortality and outcome associated with nosocomial bacteraemia (NB). Subjects and Methods: A case-control study of 176 patients was conducted to identify the risk factors for mortality of NB in ICU patients. The study was performed in emergency, surgical and general surgical ICUs with 23 beds during a 15-month period. A total of 1,450 patients were admitted to the ICUs during the study period. The USA Center for Disease Control and Prevention definitions were used to diagnose nosocomial infections. Nosocomial bacteraemia was defined as the isolation of one or more organisms from blood cultures taken at least 48 h after admission, which were not related to a problem present on admission. An assessment of whether the isolated organisms represented true bacteraemia rather than contamination was made by clinical or laboratory evidence of infection. Results: A total of 214 bacteraemia episodes were found in the 176 patients (64 female, 112 male; 51.3 ± 21.3 years old), 90 of whom died and 86 survived. The bacteraemia rate was 12.1%. The most common etiological agents of bacteraemia were Klebsiella pneumoniae: 46 (21.5%), methicillin-resistant Staphylococcus aureus: 46 (21.5%), Pseudomonas aeruginosa: 32 (14.9%), and Escherichia coli: 20 (9.3%). Multivariate analysis showed that the requirement of mechanical ventilation for more than 7 days (p < 0.001), total parenteral nutrition (p = 0.034), inotropic drug (p < 0.001), and increased creatinine level (p = 0.034) were independent risk factors for mortality of NB in ICUs. Conclusions: Nosocomial infections caused by Gram-negative bacteria continue to be one of the major sources of morbidity and mortality. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2007
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36. Dio-sensimedia: a novel culture medium for rapid detection of extended spectrum β-lactamases.
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Cagatay, Atahan A., Kocagoz, Tanil, and Eraksoy, Haluk
- Subjects
BETA lactamases ,DRUG resistance in microorganisms ,KLEBSIELLA pneumoniae ,ESCHERICHIA coli ,BACTERIA - Abstract
Background: Resistance to contemporary broad-spectrum β-lactams, mediated by extended-spectrum β-lactamases (ESBL), is an increasing problem worldwide. Many of the emerging antimicrobial resistance problems of this decade have been characterized by difficulty in the recognition of resistance in the laboratory, particularly by rapid susceptibility test methods. The plasmid-encoded ESBL represent such a resistance phenomenon that is difficult to recognize. We compared Dio-Sensimedia-ES (DSM-ES; Diomed, Istanbul, Turkey) and Mueller-Hinton (MH) agar in the double-disk synergy test (DDST) as a novel rapid system for detecting ESBL directly from bacterial culture. Methods: Sixty ESBL-producing Klebsiella pneumoniae isolates cultured from blood (30), endotracheal aspirates (20), urine (5) and pus (5), as well as 40 Escherichia coli isolates cultured from endotracheal aspirates (15), urine (10), blood (8) and pus (7) were studied. Isolates positive for ESBL by the combined disk tests were tested with the DDST using MH and DSM-ES agar to detect ESBL-mediated resistance in K. pneumoniae and E. coli. DSM-ES agar was also used to determine the susceptibility of Enterobacteriaceae and staphylococci. Results: Among 60 ESBL-producing K. pneumoniae isolates, 59 (98.3%) were identified as ESBL-positive by the DDST using MH, and 58 (96.6%), using DSM-ES agar. Of 40 ESBL-producing E. coli isolates, 38 (95%) were ESBL-positive by the DDST on MH agar, and 37 (92.5%), on DSM-ES agar. The average incubation period required for ESBL detection by the DDST on DSM-ES agar was 4 hours. Conclusions: Since the DDST results were available within 4 hours when DSM-ES agar was used, the use of this media may significantly lower the length of hospital stay, the total cost for patient care and even the mortality rate by fascilitating early treatment against ESBL-producing organisms. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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37. Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics.
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Öncü, Serkan, Özsüt, Halit, Yildirim, Ayşe, Ay, Pinar, Çakar, Nahit, Eraksoy, Haluk, and Çalangu, Semra
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LONGITUDINAL method ,INTRAVENOUS catheterization complications ,GLYCOPEPTIDE antibiotics ,CATHETERS ,STAPHYLOCOCCUS aureus - Abstract
Backround: We undertook a prospective study of all new central venous catheters inserted into patients in the intensive care units, in order to identify the risk factors and to determine the effect of glycopeptide antibiotics on catheter -- related infections. Methods: During the study period 300 patients with central venous catheters were prospectively studied. The catheters used were nontunneled, noncuffed, triple lumen and made of polyurethane material. Catheters were cultured by semiquantitative method and blood cultures done when indicated. Data were obtained on patient age, gender, unit, primary diagnosis on admission, catheter insertion site, duration of catheterization, whether it was the first or a subsequent catheter and glycopeptide antibiotic usage. Results: Ninety-one (30.3%) of the catheters were colonized and infection was found with 50 (16.7%) catheters. Infection was diagnosed with higher rate in catheters inserted via jugular vein in comparison with subclavian vein (95% CI: 1.32-4.81, p = 0.005). The incidence of infection was higher in catheters which were kept in place for more than seven days (95% CI 1.05-3.87, p = 0.03). The incidence of infection was lower in patients who were using glycopeptide antibiotic during catheterization (95% CI: 1.49-5.51, p = 0.005). The rate of infection with Gram positive cocci was significantly lower in glycopeptide antibiotic using patients (p = 0.01). The most commonly isolated organism was Staphylococcus aureus (n = 52, 37.1%). Conclusion: Duration of catheterization and catheter insertion site were independent risk factors for catheter related infection. Use of glycopeptide antibiotic during catheterization seems to have protective effect against catheter related infection. [ABSTRACT FROM AUTHOR]
- Published
- 2003
38. Recruitment maneuver: does it promote bacterial translocation?
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Cakar, Nahit, Akinci, Ozkan, Tugrul, Simru, Ozcan, Perihan Ergin, Esen, Figen, Eraksoy, Haluk, Cagatay, Atahan, Telci, Lütfi, and Nahum, Avi
- Published
- 2002
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39. Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report.
- Author
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Çagatay, Atahan A., Öncü, Serkan S., Çalangu, Semra S., Yildirmak, Taner T., Özsüt, Halit H., and Eraksoy, Haluk H.
- Subjects
MUCORMYCOSIS ,AMPHOTERICIN B ,SURGERY ,DIABETES ,THERAPEUTICS - Abstract
Background: Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis. Case Presentation: A 31-year-old diabetic man presented to the outpatient clinic with the following signs and symptoms: headache, periorbital pain, swelling and loss of vision in the right eye. On physical examination his right eye was red and swollen. There was periorbital cellulitis and the conjunctiva was edematous. KOH preparation of purulent discharge showed broad, ribbonlike, aseptate hyphae when examined under a fluorescence microscope. Cranial MRI showed involvement of the right orbit, thrombosis in cavernous sinus and infiltrates at ethmoid and maxillary sinuses. Mucormycosis was diagnosed based on these findings. Amphotericin B (AmBisome®; 2 mg/kg.d) was initiated after the test doses. Right orbitectomy and right partial maxillectomy were performed; the lesions in ethmoid and maxillary sinuses were removed. The duration of the liposomal amphotericin B therapy was approximately 6 months and the total dose of liposomal amphotericin B used was 32 grams. Liposomal amphotericin B therapy was stopped six months later and oral fluconazole was started. Conclusions: Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone. [ABSTRACT FROM AUTHOR]
- Published
- 2001
40. Immunization of renal transplant recipients with pneumococcal polysaccharide vaccine.
- Author
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Kazancıoğlu, Rümeyza, Sever, Mehmet Ş, Yüksel-Önel, Derya, Eraksoy, Haluk, Yıldız, Alaattin, Çelik, A Vedat, Kayacan, Seyit M, and Badur, Selim
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KIDNEY transplantation ,PNEUMOCOCCAL vaccines ,POLYSACCHARIDES ,IMMUNIZATION - Abstract
Background: Streptococcus pneumoniae, a common pathogen leading to pneumonia, is a cause of morbidity and mortality in immunosuppressed patients. Vaccination against this agent can be recommended for immunosuppressed patients, including those with chronic renal failure, nephrotic syndrome and renal transplant recipients; however, a diminished immune response and loss of protective antibodies have been observed.Patients and methods: In our prospective study, the efficacy and side effects of polyvalent pneumococcal vaccination were investigated in renal transplant recipients. A total of 21 patients (6 female, 15 male) with well-functioning renal allografts, who had transplant surgery at least 2 months before, were included in the study. The patients were stratified according to the immunosuppressive protocol and 8 received double, while 13 received triple, immunosuppresive agents. After obtaining basal serum samples, all cases were vaccinated with the 0.5 mL intramuscular administration of polyvalent polysaccharide pneumococcal vaccine (Pneumo 23 Pasteur–Merieux, lot No: K 1131).Results: Following a mean of 6 wk in all patients and also a mean of 12 wk in 12 patients, serum samples were again obtained to measure pneumococcal antibodies. Antibody titers following 6 and 12 wk of vaccination were significantly higher, as compared with basal values in all patients, except one. These titers did not show any statistically significant difference between double and triple therapies. There was no significant difference between the 12th and 6th wk postvaccination antibody titers. No systemic or local adverse effects were observed.Conclusion: Pneumococcal vaccination is safe and effective in patients with well-functioning renal allografts, at least in the short term. This vaccination policy may be useful for preventing invasive pneumococcal disease in immunosuppressed patients. [ABSTRACT FROM AUTHOR]
- Published
- 2000
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41. Immune Response to Haemophilus influenzae Type b Vaccination inRenal Transplant Recipients with Well-Functioning Allografts.
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Sever, Mehmet Ş., Ylidiz, Alaattin, Eraksoy, Haluk, Badur, Selim, Yüksel-Önel, Derya, Görçin, Bilal, Turk, Süleyman, and Erkoç, Reha
- Abstract
Background: Haemophilus influenzae infection is a mild and self-limited disease in the healthy population. However, it may show an aggressive course in the immunocompromised state which underlines the importance of vaccination against this agent. On the other hand, posttranplant immunosuppression may impair immune responses and thus the efficacy of the vaccination. Methods: Forty-three renal transplant recipients with well-functioning allografts were immunized with H. influenzae type b vaccine in order to investigate the immune response. The patients received a double or a triple immunosuppressive protocol. Seven healthy members of the dialysis unit served as controls. After obtaining basal serum samples, the patients and the control subjects were immunized with H. influenzae type b conjugate vaccine. After 6 and 12 weeks, serum samples obtained again to determine H. influenzae type b antibody titers. Results: The antibody titers 6 and 12 weeks after vaccination were significantly higher as compared with the basal values, similar to those of the control subjects. These titers did not show statistically significant differences between the double and triple immunosuppressive therapy groups. After 12 weeks of vaccination, the antibody titers did not show a statistically significant difference as compared with those obtained after 6 weeks. Conclusion: H. influenzae type b vaccination is safe and effective in patients with well-functioning renal allografts and should be recommended to renal transplant recipients who may have the risk of invasive disease on the basis of the immunosuppressive state. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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42. Spontaneous ascitic infection in different cirrhotic groups: prevalence, risk factors and the efficacy of cefotaxime therapy.
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Kaymakoglu, Sabahattin, Eraksoy, Haluk, Ökten, Atilla, Demir, Kadir, Çalangu, Semra, Çakaloglu, Yilmaz, Boztas, Güngör, Besisik, Fatih, Kaymakoglu, S, Eraksoy, H, Okten, A, Demir, K, Calangu, S, Cakaloglu, Y, Boztas, G, and Besisik, F
- Published
- 1997
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43. Neisseria meningitidis with Decreased Susceptibility to Penicillin in Istanbul, Turkey.
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Punar, Metin, Eraksoy, Haluk, Cagatay, A. Atahan, Ozsut, Halit, Kaygusuz, Arif, Calangu, Semra, and Dilmener, Murat
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NEISSERIA meningitidis , *PENICILLIN - Abstract
This study was conducted to estimate the rate of decreased susceptibility to penicillin (MIC > 0.06-1 m g/ml) in Neisseria meningitidis isolates in Istanbul, Turkey. A total of 30 isolates collected during a 1-y period from patients with meningitis and from nasopharyngeal carriers were tested for penicillin and cefotaxime susceptibility using the E-test. Two out of 12 (17%) clinical isolates and 11/18 (61%) nasopharyngeal isolates showed decreased susceptibility to penicillin with MICs in the range 0.094-1.0 m g/ml, giving an overall resistance of 43% (n=13). These data show that continued surveillance of trends in antimicrobial susceptibility of N. meningitidis is important for detecting the emergence of N. meningitidis strains with MICs > 1 m g/ml which may pose serious therapeutic problems. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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44. POSTTRANSPLANT MALARIA1.
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Türkmen, Aydin, Sever, Mehmet Ş., Ecder, Tevfik, Yildiz, Alaattin, Aydin, Ali E., Erkoç, Reha, Eraksoy, Haluk, Eldegez, Uluğ, and Ark, Ergin
- Published
- 1996
45. Emergence of high-level fluoroquinolone-resistant Streptococcus pneumoniae in Turkey
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Ak, Öznur, Benzonana, Nur, Özer, Serdar, and Eraksoy, Haluk
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- 2003
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46. Outcomes of initial antiretroviral treatment (ART) among recently diagnosed HIV patients in HIV-TR cohort, 2011-2012.
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Korten, Volkan, Gökengin, Deniz, Fincanci, Muzaffer, Yildirmak, Taner, Uzun Kes, Nuray, Taşdelen Fişgin, Nuriye, Inan, Dilara, Eraksoy, Haluk, Akalin, Halis, and Kaptan, Figen
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HIV infections ,THERAPEUTICS ,ANTIVIRAL agents ,HEALTH outcome assessment ,CD4 lymphocyte count ,EMTRICITABINE-tenofovir - Abstract
Introduction HIV-TR is a recently established (2012) multicentre cohort in Turkey. The aim of this study is to analyze epidemiological, immunologic and virologic data of recently diagnosed HIV patients. Materials and Methods Epidemiologic, clinical and laboratory data of all patients diagnosed in 2011 and 2012 were recorded by a web-based data collection system, retrospectively. Results A total of 693 patients (561 male, 132 female) at 24 sites were enrolled. The median age at first presentation for HIV care was 36. The proportion of patients presenting with advanced HIV disease (CD4 count<200/mm
3 or presenting with an AIDS-defining event) was 30.6%; and 52.4% of patients were late presenters (CD4 count<350/mm3 or presenting with an AIDS-defining event). Median CD4 counts at presentation and before treatment were 344 (IQR: 175-540) and 295 (IQR: 150-430), respectively. Pretreatment CD4 count was >500 copies/mL in 18.5% of patients. Of 531 patients receiving ART, initial combinations consist of tenofovir/emtricitabine (TDF/FTC) plus efavirenz (EFV) in 48.2% and TDF/FTC plus lopinavir/ritonavir (LPV/r) in 37.5% and other combinations in 14.3% of the patients. Pre-treatment HIV-RNA was over 100.000 copies/mL in 52.3% of patients. At Weeks 24 and 48, HIV-RNA were<50 copies/mL in 63,4% of 385 patients and 82% of 311 patients reported to be still on ART and had a viral load measurement, respectively. Median pretreatment CD4 count was lower for TDF/FTC+LPV/r recipients than TDF/FTC+EFV recipients (250 vs 316) (p<0.05). The median increase from baseline CD4 cell count was 230 in TDF/FTC+LPV/r group, 193 in TDF/FTC+EFV group and 216 among all treated patients. Of 531 patients receiving ART, 11 had died and 19 were lost to follow-up. Conclusion Despite 52.4% of recently diagnosed patients were late presenters; a high rate of virologic suppression was achieved in HIV-TR Cohort. A national HIV testing strategy targeting subpopulations with higher risk is urgently needed. [ABSTRACT FROM AUTHOR]- Published
- 2014
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47. Hantavirus İnfeksiyonu: Daha Önce Tanıştık mı?
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Eraksoy, Haluk
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HANTAVIRUS diseases - Published
- 2011
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48. Frequency of CCR5-Δ32, CCR2-64I and SDF1-3'A alleles in HIV-infected and uninfected patients in Istanbul, Turkey.
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Köksal, Muammer Osman, Akgül, Baki, Beka, Hayati, Çiftçi, Sevgi, Keskin, Fahriye, Eraksoy, Haluk, and Ağaçfidan, Ali
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RESTRICTION fragment length polymorphisms , *GENETIC variation , *HIV-positive persons , *HIV , *ALLELES , *INFECTION - Abstract
Introduction: Co-receptors involved in cell entry of the human immunodeficiency virus (HIV) and mutations in genes encoding their ligands may play a role in the susceptibility to infection and resistance to the progression of the infection. The best studied mutations that can exist in these genes are the CCR5-Δ32, CCR2-64I and SDF1-3'A mutations. The frequency of these mutations vary from continent to continent and even from region to region. However, there is limited information on their distribution throughout the Turkish population. Istanbul is the city with the highest number of documented HIV-infected patients in Turkey, which can be attributed to the population size. The aim of this study was to determine the distribution of three AIDS-related gene variants among HIV-infected and uninfected population in Istanbul, Turkey and to estimate the contribution of these variants to susceptibility or resistance to HIV. Methodology: A total of 242 healthy individuals and 200 HIV-positive patients were included in the study. CCR5 polymorphisms were genotyped by polymerase chain reaction. CCR2 and SDF1 polymorphisms were genotyped using PCR restriction fragment length polymorphism (PCR-RFLP). Results: The allelic frequencies for CCR5-Δ32, CCR2-64I and SDF1-3'A were 4.07%, 19.8% and 28.7%, respectively. No individual was found to carry the homozygous CCR5-Δ32 mutation in either cohort. No polymorphism was found to be significantly elevated in the HIVinfected cohort compared to the healthy group. Conclusions: The distribution of CCR5-Δ32, CCR2-64I, and SDF1-3'A variants does not differ between HIV-infected and uninfected patients. CCR2-64I and SDF1-3'A frequencies are relatively high where as the frequency of CCR5-Δ32 is low. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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49. Molecular Characterization of Drug Resistance in Hepatitis B Viruses Isolated from Patients with Chronical Infection in Turkey.
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Asan, Ali, Sayan, Murat, Akhan, Sila, Koruk, Suda Tekin, Aygen, Bilgehan, Sirmatel, Fatma, Eraksoy, Haluk, Tuna, Nazan, Köse, Sukran, Kaya, Ali, Tulek, Necla Eren, Demir, Nazlim Aktug, Mistik, Resit, Ormen, Bahar, Korkmaz, Fatime, Yildirmak, Taner, Ural, Onur, Aydin, Mehtap, Turgut, Huseyin, and Gunal, Ozgur
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CHRONIC hepatitis B , *ANTIGENS , *ANTIVIRAL agents , *DNA , *DRUG resistance , *HEPATITIS B , *GENETIC mutation , *POLYMERASE chain reaction , *DATA analysis software , *SEQUENCE analysis , *DIAGNOSIS - Abstract
Background: Hepatitis B virus (HBV) has a high mutation rate due to its unusual replication strategy leading to the production of a large number of virions with single and double mutations. The mutations, in turn, are associated with the development of drug resistance to nucleos(t)ide analogs (NUCs) in patients before and during NUCs therapy. Objectives: The current study aimed at investigating the molecular characterization of HBV in Turkish patients with chronic hepatitis B (CHB) infection. Methods: Polymerase chain reaction (PCR) amplificationanddirect sequencing procedures were used to analyze mutations. The detected drug resistance mutations were divided into the nucleos(t)ide analogs primary, partial, and compensatory resistance groups. The amino acid substitutions of hepatitis B surface antigen (HBsAg) were categorized into antiviral drug - associated potential vaccine - escape mutations (ADAPVEMs) and typical HBsAg amino acid substitutions, which included hepatitis B hyperimmunoglobulin (HBIg) - selected escape mutation, vaccine escape mutation, hepatitis B misdiagnosis, and immune - selected amino acid substitutions. Results: The number of patients included in the study was 528 out of which 271 (51.3%) were treatment - naive and 351 (66.3%) were hepatitis B e antigen (HBeAg) - negative. Moreover, 325 (61.6%) were males with a mean age of 38 years (range: 18 - 69). Primary, partial, and compensatory resistance to NUCs was reported in 174 (32.9%) patients. Six different ADAPVEM motifs were determined in both treatment - naive and treatment - experienced patients, namely, sF161L/rtI169X, sE164D/rtV173L, sL172L/rtA181T, sL173F/rtA181V, sS195M/rtM204V, and sS196L/rtM204I. The prevalence of ADAPVEMs and typical HBsAg escape mutations was 5.3% (n = 28) and 34.8% (n = 184), respectively. Conclusions: The analysis of drug resistance should constitute a fundamental part of the follow - up period of patients with CHB undergone treatment with NUCs. The surveillance of development of drug resistance mutations, while receiving treatment for hepatitis B is of paramount importance to monitor and control the emerging resistance. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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50. Trends and factors associated with modification or discontinuation of the initial antiretroviral regimen during the first year of treatment in the Turkish HIV-TR Cohort, 2011–2017
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Volkan Korten, Deniz Gökengin, Gülhan Eren, Taner Yıldırmak, Serap Gencer, Haluk Eraksoy, Dilara Inan, Figen Kaptan, Başak Dokuzoğuz, Ilkay Karaoğlan, Ayşe Willke, Mehmet Gönen, Önder Ergönül, on behalf of the HIV-TR Study Group, Gönen, Mehmet (ORCID 0000-0002-2483-075X & YÖK ID 237468), Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Korten, Volkan, Gökengin, Deniz, Eren, Gülhan, Yıldırmak, Taner, Gençer, Serap, Eraksoy, Haluk, İnan, Dilara, Kaptan, Figen, Dokuzoğuz, Başak, Karaoglan, İlkay, Willke, Ayşe, HIV-TR Study Group, College of Engineering, School of Medicine, Department of Industrial Engineering, Ege Üniversitesi, Gokengin, Deniz, Eren, Gulhan, Yildirmak, Taner, Gencer, Serap, Inan, Dilara, Dokuzoguz, Basak, Karaoglan, Ilkay, Willke, Ayse, Gonen, Mehmet, Ergonul, Onder, İstanbul Kent Üniversitesi, Fakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, and To, Ayşe Willke
- Subjects
Male ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Integrase strand transfer inhibitor ,Anti-HIV Agents ,DURABILITY ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,THERAPY ,Sexual and Gender Minorities ,Antiretroviral Therapy, Highly Active ,Virology ,Internal medicine ,INFECTION ,medicine ,Humans ,Pharmacology (medical) ,Homosexuality, Male ,Treatment outcome ,Antiretroviral therapy ,Cohort study ,Treatment modification ,Reverse-transcriptase inhibitor ,business.industry ,Proportional hazards model ,Research ,NAIVE ,Viral Load ,EFFICACY ,Discontinuation ,Regimen ,Anti-Retroviral Agents ,Cohort ,Infectious diseases ,Molecular Medicine ,Female ,business ,lcsh:RC581-607 ,medicine.drug - Abstract
Background: There is limited evidence on the modification or stopping of antiretroviral therapy (ART) regimens, including novel antiretroviral drugs. The aim of this study was to evaluate the discontinuation of first ART before and after the availability of better tolerated and less complex regimens by comparing the frequency, reasons and associations with patient characteristics. Methods: A total of 3019 ART-naive patients registered in the HIV-TR cohort who started ART between Jan 2011 and Feb 2017 were studied. Only the first modification within the first year of treatment for each patient was included in the analyses. Reasons were classified as listed in the coded form in the web-based database. Cumulative incidences were analysed using competing risk function and factors associated with discontinuation of the ART regimen were examined using Cox proportional hazards models and Fine-Gray competing risk regression models. Results: The initial ART regimen was discontinued in 351 out of 3019 eligible patients (11.6%) within the first year. The main reason for discontinuation was intolerance/toxicity (45.0%), followed by treatment simplification (9.7%), patient willingness (7.4%), poor compliance (7.1%), prevention of future toxicities (6.0%), virologic failure (5.4%), and provider preference (5.4%). Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based (aHR = 4.4, [95% CI 3.0-6.4]; p < 0.0001) or protease inhibitor (PI)-based regimens (aHR = 4.3, [95% CI 3.1-6.0]; p < 0.0001) relative to integrase strand transfer inhibitor (InSTI)-based regimens were significantly associated with ART discontinuation. ART initiated at a later period (2015-Feb 2017) (aHR = 0.6, [95% CI 0.4-0.9]; p < 0.0001) was less likely to be discontinued. A lower rate of treatment discontinuation for intolerance/toxicity was observed with InSTI-based regimens (2.0%) than with NNRTI- (6.6%) and PI-based regimens (7.5%) (p < 0.001). The percentage of patients who achieved HIV RNA < 200 copies/mL within 12 months of ART initiation was 91% in the ART discontinued group vs. 94% in the continued group (p > 0.05). Conclusion: ART discontinuation due to intolerance/toxicity and virologic failure decreased over time. InSTI-based regimens were less likely to be discontinued than PI- and NNRTI-based ART., Gilead SciencesGilead Sciences, This study was funded by Gilead Sciences.
- Published
- 2021
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