17 results on '"Enrico Melis"'
Search Results
2. Analysis of predictive factors of unforeseen nodal metastases in resected clinical stage I NSCLC
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Filippo Tommaso Gallina, Daniele Marinelli, Riccardo Tajè, Daniele Forcella, Gabriele Alessandrini, Fabiana Letizia Cecere, Francesca Fusco, Paolo Visca, Isabella Sperduti, Vincenzo Ambrogi, Federico Cappuzzo, Enrico Melis, and Francesco Facciolo more...
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early stage NSCLC ,upstaging ,stage I ,nodal disease ,lymphadenectomy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundDespite notable advances made in preoperative staging, unexpected nodal metastases after surgery are still significantly detected. In this study we aim to analyze the upstaging rate in patients with clinical stage I NSCLC without evidence of nodal disease in the preoperative staging who underwent lobectomy and radical lymphadenectomy.MethodsPatients who underwent lobectomy and systematic lymphadenectomy for clinical stage I NSCLC were evaluated. Exclusion criteria included the neoadjuvant treatment, incomplete resection and no adherence to preoperative guidelines.ResultsA total of 297 patients were included in the study. 159 patients were female, and the median age was 68 (61 - 73). The variables that showed a significant correlation with the upstaging rate at the univariate analysis were the number of resected lymph nodes and micropapillar/solid adenocar-cinoma subtype. This result was confirmed in the multivariate analysis with a OR= 2.545 (95%CI 1.136-5.701; p=0.02) for the number of resected lymph nodes and a OR=2.717 (95%CI 1.256-5.875; p=0.01) for the high-grade pattern of adenocarcinoma.ConclusionOur results showed that in a homogeneous cohort of patients with clinical stage I NSCLC, the number of resected lymph nodes and the histological subtype of adenocarcinoma can significantly be associated with nodal metastasis. more...
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- 2023
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- View/download PDF
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3. Perioperative outcomes of robotic lobectomy for early-stage non-small cell lung cancer in elderly patients
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Filippo Tommaso Gallina, Riccardo Tajè, Daniele Forcella, Valeria Gennari, Paolo Visca, Federico Pierconti, Cecilia Coccia, Federico Cappuzzo, Isabella Sperduti, Francesco Facciolo, and Enrico Melis
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NSCLC ,rats ,mediastinal lymphadenectomy ,elderly ,postoperative complications ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
IntroductionMinimally invasive surgery has become the standard for the early-stage non-small cell lung cancer (NSCLC). The appropriateness of the kind of lung resection for the elderly patients is still debated.MethodsWe retrospectively reviewed patients with older than 75 years who underwent robotic lobectomy between May 2016 to June 2022. We selected 103 patients who met the inclusion criteria of the study. The preoperative cardiorespiratory functional evaluations were collected, and the risk of postoperative complications was calculated according to the Charlson Comorbidity Index, the American College of Surgery surgical risk calculator (ACS-NSQIP), EVAD score, and American Society of Anesthesiology (ASA) score. The patients were divided in two groups according to the presence of postoperative complications.ResultsForty-three patients were female, and 72.8% of the total population were former or active smokers. Thirty-five patients reported postoperative complications. The analysis of the two groups showed that the predicted postoperative forced expiratory volumes in the first second (FEV1) and forced vital capacity (FVC) were significantly lower in patients presenting postoperative complications (p=0.04). Moreover, the upstaging rate and the unexpected nodal metastases were higher in the postoperative complication groups.ConclusionRobotic-assisted lobectomy for early-stage lung cancer is a safe and feasible approach in selected elderly patients. The factors that could predict the complication rate was the predicted postoperative FEV1 and the nodal disease. more...
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- 2022
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4. Fluorescence-guided lung nodule identification during minimally invasive lung resections
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Riccardo Tajè, Filippo Tommaso Gallina, Daniele Forcella, Giulio Eugenio Vallati, Federico Cappelli, Federico Pierconti, Paolo Visca, Enrico Melis, and Francesco Facciolo
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NSCLC ,NIR-guided surgery ,minimally invasive thoracic surgery ,RATS ,VATS ,lung cancer ,Surgery ,RD1-811 - Abstract
In the last few years, minimally invasive surgery has become the standard routine practice to manage lung nodules. Particularly in the case of robotic thoracic surgery, the identification of the lung nodules that do not surface on the visceral pleura could be challenging. Therefore, together with the evolution of surgical instruments to provide the best option in terms of invasiveness, lung nodule localization techniques should be improved to achieve the best outcomes in terms of safety and sensibility. In this review, we aim to overview all principal techniques used to detect the lung nodules that do not present the visceral pleura retraction. We investigate the accuracy of fluorescence guided thoracic surgery in nodule detection and the differences among the most common tracers used. more...
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- 2022
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5. Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells
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Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, and Francesco Fazi more...
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thymoma ,thymic carcinoma ,thymic epithelial tumors (TETs) ,ncRNAs (non coding RNAs) ,miRNA - microRNA ,lncRNA - long noncoding RNA ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization. Long non-coding RNAs (lncRNAs) are emerging as relevant gene expression modulators involved in the deregulation of several networks in almost all types of human cancer, including TETs. LncRNAs act at different control levels in the regulation of gene expression, from transcription to translation, and modulate several pathways relevant to cell fate determination under normal and pathological conditions. The activity of lncRNAs is strongly dependent on their expression, localization, and post-transcriptional modifications. Starting from our recently published studies, this review focuses on the involvement of lncRNAs in the acquisition of malignant traits by neoplastic thymic epithelial cells, and describes the possible use of these molecules as targets for the design of novel therapeutic approaches specific for TET. Furthermore, the involvement of lncRNAs in myasthenia gravis (MG)-related thymoma, which is still under investigation, is discussed. more...
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- 2022
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6. The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma
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Luigino Calzetta, Alfredo Chetta, Marina Aiello, Annalisa Frizzelli, Josuel Ora, Enrico Melis, Francesco Facciolo, Lorenzo Ippoliti, Andrea Magrini, and Paola Rogliani
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airway hyperresponsiveness ,asthma ,BNT162b2 ,bronchospasm ,comirnaty ,COVID-19 ,Medicine - Abstract
The BNT162b2 COVID-19 vaccine is composed of lipid-nanoparticles (LNP) containing the mRNA that encodes for SARS-CoV-2 spike glycoprotein. Bronchospasm has been reported as an early reaction after COVID-19 mRNA vaccines in asthmatic patients. The aim of this study was to investigate the acute impact of BNT162b2 in a human ex vivo model of severe eosinophilic asthma. Passively sensitized human isolated bronchi were challenged with the platelet-activating factor to reproduce ex vivo the hyperresponsiveness of airways of patients suffering from severe eosinophilic asthma. BNT162b2 was tested on the contractile sensitivity to histamine and parasympathetic activation via electrical field stimulation (EFS); some experiments were performed after mRNA denaturation. BNT162b2 increased the resting tone (+11.82 ± 2.27%) and response to histamine in partially contracted tissue (+42.97 ± 9.64%) vs. the control (p < 0.001); it also shifted the concentration-response curve to histamine leftward (0.76 ± 0.09 logarithm) and enhanced the response to EFS (+28.46 ± 4.40%) vs. the control. Denaturation did not significantly modify (p > 0.05) the effect of BNT162b2. BNT162b2 increases the contractile sensitivity to histamine and parasympathetic activation in hyperresponsive airways, a detrimental effect not related to the active component but to some excipient. A possible candidate for the bronchospasm elicited by BNT162b2 could be the polyethylene glycol/macrogol used to produce LNP. more...
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- 2023
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7. Nodal Upstaging Evaluation After Robotic-Assisted Lobectomy for Early-Stage Non-small Cell Lung Cancer Compared to Video-Assisted Thoracic Surgery and Thoracotomy: A Retrospective Single Center Analysis
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Filippo Tommaso Gallina, Enrico Melis, Daniele Forcella, Edoardo Mercadante, Daniele Marinelli, Serena Ceddia, Federico Cappuzzo, Sabrina Vari, Fabiana Letizia Cecere, Mauro Caterino, Antonello Vidiri, Paolo Visca, Simonetta Buglioni, Isabella Sperduti, Mirella Marino, and Francesco Facciolo more...
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NSCLC ,robotic thoracic surgery (RATS) ,mediastinal lymphadenectomy ,VATS ,thoracic oncology ,Surgery ,RD1-811 - Abstract
Introduction: The standard surgical procedures for patients with early-stage NSCLC is lobectomy-associated radical lymphadenectomy performed by using the thoracotomy approach. In the last few years, minimally invasive techniques have increasingly strengthened their role in lung cancer treatment, especially in the early stage of the disease. Although the lobectomy technique has been accepted, controversy still surrounds lymph node dissection. In our study, we analyze the rate of upstaging early non-small cell lung cancer patients who underwent radical surgical treatment using the robotic and the VATS techniques compared to the standard thoracotomy approach.Methods and Materials: We retrospectively reviewed patients who underwent a lobectomy and radical lymphadenectomy at our Institute between 2010 and 2019. We selected 505 patients who met the inclusion criteria of the study: 237 patients underwent robotic surgery, 158 patients had thoracotomy, and 110 patients were treated with VATS. We analyzed the demographic features between the groups as well as the nodal upstaging rate after pathological examination, the number of dissected lymph nodes and the ratio of dissected lymph nodes to metastatic lymph nodes of the three groups.Results: The patients of the three groups were homogenous with respect to age, sex, and histology. The postoperative major morbidity rate was significantly higher in the thoracotomy group, and hospital stay was significantly longer. The percentage of the mediastinal nodal upstaging rate and the number of dissected lymph nodes was significantly higher in the robotic group compared with the VATS group. The ratio of dissected lymph nodes to metastatic lymph nodes was significantly lower compared with the VATS group and the thoracotomy group.Discussion: The prognostic impact of the R(un) status is still highly debated. A surgical approach that allows better results in terms of resection has still not been defined. Our results show that robotic surgery is a safe and feasible approach especially regarding the accuracy of mediastinal lymphadenectomy. These findings can lead to defining a more precise pathological stage of the disease and, if necessary, to more accurate postoperative treatment. more...
- Published
- 2021
- Full Text
- View/download PDF
8. Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes
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Enrico Melis, Enzo Gallo, Simona di Martino, Filippo Tommaso Gallina, Valentina Laquintana, Beatrice Casini, Paolo Visca, Federica Ganci, Gabriele Alessandrini, Mauro Caterino, Fabiana Letizia Cecere, Chiara Mandoj, Arianna Papadantonakis, Nicoletta De Bello, Rossano Lattanzio, Giovannella Palmieri, Marina Chiara Garassino, Nicolas Girard, Laura Conti, Giovanni Blandino, Francesco Fazi, Francesco Facciolo, Edoardo Pescarmona, Gennaro Ciliberto, and Mirella Marino more...
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thymic epithelial tumors ,thymoma ,thymic carcinoma ,biobank ,microRNA ,TCGA ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas tend to show aggressive behavior and extrathoracic spread. Moreover, the interplay of epithelial cells and thymocytes in thymomas causes complex immune derangement and related systemic autoimmune diseases. Due to their rare occurrence and to the limited funding opportunities available for rare tumors, it is challenging to make advances in clinical and translational research in TET. The authors of this paper are all members of a multidisciplinary clinical and research thoracic tumor team. Strong input was given to the team by long-standing expertise in TET in the Pathology Department. In addition, thanks to the collaboration between research units at our Institute as well as to national collaborations, over the last 10 years we were able to perform several tissue-based research studies. The most recent studies focused on microRNA and on functional studies on the thymic carcinoma cell line 1889c. The recent implementation of our biobank now provides us with a new tool for networking collaborative research activities. Moreover, the participation in a worldwide community such as ITMIG (International Thymic Malignancy Interest Group) has allowed us to significantly contribute toward fundamental projects/research both in tissue-based studies (The Cancer Genome Atlas) and in clinical studies (TNM staging of TET). Our achievements derive from constant commitment and long-standing experience in diagnosis and research in TET. New perspectives opened up due to the establishment of national [the Italian Collaborative Group for ThYmic MalignanciEs (TYME)] and European reference networks such as EURACAN, for an empowered joint clinical action in adult solid rare tumors. The challenge we face still lies in the advancement of clinical and basic science in thymic epithelial malignancies. more...
- Published
- 2020
- Full Text
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9. Transesophageal Endoscopic Ultrasound Fine Needle Biopsy for the Diagnosis of Mediastinal Masses: A Retrospective Real-World Analysis
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Daniela Assisi, Filippo Tommaso Gallina, Daniele Forcella, Riccardo Tajè, Enrico Melis, Paolo Visca, Federico Pierconti, Emanuela Venti, and Francesco Facciolo
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endoscopic ultrasound ,fine needle aspiration biopsy ,mediastinal lymph node ,para-mediastinal masses ,General Medicine - Abstract
Background: Endoscopic ultrasound (EUS) plays an important role in the diagnosis and staging of thoracic disease. Our report studies the diagnostic performance and clinical impact of EUS fine needle aspiration (FNA) in a homogenous cohort of patients according to the distribution of the enlarged MLNs or pulmonary masses. Methods: We retrospectively reviewed the diagnostic performance of 211 EUS-FNA in 200 consecutive patients with enlarged or PET-positive MLNs and para-mediastinal masses who were referred to our oncological center between January 2019 and May 2020. Results: The overall sensitivity of EUS-FNA was 85% with a corresponding negative predictive value (NPV) of 56% and an accuracy of 87.5%. The sensitivity and accuracy in patients with abnormal MLNs were 81.1% and 84.4%, respectively. In those with para-mediastinal masses, sensitivity and accuracy were 96.4% and 96.8%. The accuracy for both masses and lymph nodes was 100%, and in the LAG (left adrenal gland), it was 66.6%. Conclusions: Our results show that, in patients with suspected mediastinal masses, EUS-FNA is an accurate technique to evaluate all reachable mediastinal nodal stations, including station 5. more...
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- 2022
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10. METTL3 contribution to cell proliferation in Thymic Epithelial Tumor Cells
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Iaiza, Alessia, Tito, Claudia, Ianniello, Zaira, Federica, Ganci, Valentina, Laquintana, Enzo, Gallo, Andrea, Sacconi, Masciarelli, Silvia, DE ANGELIS, Luciana, Aversa, Sara, Diso, Daniele, Anile, Marco, Petrozza, Vincenzo, Francesco, Facciolo, Enrico, Melis, Edoardo, Pescarmona, Venuta, Federico, Mirella, Marino, Giovanni, Blandino, Giulia, Fontemaggi, Fatica, Alessandro, and Fazi, Francesco more...
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c-myc ,mettl3 ,lncRNAs ,m6a ,thymic epithelial tumors ,thymic carcinoma ,malat1 - Published
- 2022
11. Nodal Upstaging Evaluation After Robotic-Assisted Lobectomy for Early-Stage Non-small Cell Lung Cancer Compared to Video-Assisted Thoracic Surgery and Thoracotomy: A Retrospective Single Center Analysis
- Author
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Antonello Vidiri, Fabiana Letizia Cecere, Sabrina Vari, Francesco Facciolo, Edoardo Mercadante, Serena Ceddia, Paolo Visca, Federico Cappuzzo, Daniele Forcella, Simonetta Buglioni, Isabella Sperduti, Filippo Tommaso Gallina, Mirella Marino, Mauro Caterino, Enrico Melis, and Daniele Marinelli more...
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medicine.medical_specialty ,RD1-811 ,NSCLC ,robotic thoracic surgery (RATS) ,mediastinal lymphadenectomy ,VATS ,thoracic oncology ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Robotic surgery ,Thoracotomy ,Stage (cooking) ,Lung cancer ,Lymph node ,Original Research ,business.industry ,medicine.disease ,Surgery ,Dissection ,medicine.anatomical_structure ,030228 respiratory system ,Lymphadenectomy ,Lymph ,business - Abstract
Introduction: The standard surgical procedures for patients with early-stage NSCLC is lobectomy-associated radical lymphadenectomy performed by using the thoracotomy approach. In the last few years, minimally invasive techniques have increasingly strengthened their role in lung cancer treatment, especially in the early stage of the disease. Although the lobectomy technique has been accepted, controversy still surrounds lymph node dissection. In our study, we analyze the rate of upstaging early non-small cell lung cancer patients who underwent radical surgical treatment using the robotic and the VATS techniques compared to the standard thoracotomy approach.Methods and Materials: We retrospectively reviewed patients who underwent a lobectomy and radical lymphadenectomy at our Institute between 2010 and 2019. We selected 505 patients who met the inclusion criteria of the study: 237 patients underwent robotic surgery, 158 patients had thoracotomy, and 110 patients were treated with VATS. We analyzed the demographic features between the groups as well as the nodal upstaging rate after pathological examination, the number of dissected lymph nodes and the ratio of dissected lymph nodes to metastatic lymph nodes of the three groups.Results: The patients of the three groups were homogenous with respect to age, sex, and histology. The postoperative major morbidity rate was significantly higher in the thoracotomy group, and hospital stay was significantly longer. The percentage of the mediastinal nodal upstaging rate and the number of dissected lymph nodes was significantly higher in the robotic group compared with the VATS group. The ratio of dissected lymph nodes to metastatic lymph nodes was significantly lower compared with the VATS group and the thoracotomy group.Discussion: The prognostic impact of the R(un) status is still highly debated. A surgical approach that allows better results in terms of resection has still not been defined. Our results show that robotic surgery is a safe and feasible approach especially regarding the accuracy of mediastinal lymphadenectomy. These findings can lead to defining a more precise pathological stage of the disease and, if necessary, to more accurate postoperative treatment. more...
- Published
- 2021
- Full Text
- View/download PDF
12. Maintaining the quality standard of oncological thoracic surgery unit activity during the COVID ‐19 pandemic: experience of no COVID‐19 hospital
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Gabriele Alessandrini, Filippo Tommaso Gallina, Enrico Melis, Marco Chiappetta, Daniele Forcella, Edoardo Mercadante, and Francesco Facciolo
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,General Medicine ,Unit (housing) ,Cardiothoracic surgery ,Quality standard ,Emergency medicine ,Pandemic ,medicine ,Surgery ,business ,Reference standards - Published
- 2020
- Full Text
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13. Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes
- Author
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Nicolas Girard, Mirella Marino, Gabriele Alessandrini, Laura Conti, Mauro Caterino, Giovannella Palmieri, Fabiana Letizia Cecere, Nicoletta De Bello, Enzo Gallo, Marina Chiara Garassino, Paolo Visca, Gennaro Ciliberto, Beatrice Casini, Federica Ganci, Francesco Facciolo, Francesco Fazi, Rossano Lattanzio, Simona di Martino, Chiara Mandoj, Valentina Laquintana, Giovanni Blandino, Enrico Melis, Filippo Tommaso Gallina, Edoardo Pescarmona, and Arianna Papadantonakis more...
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Cancer Research ,Thymoma ,Basic science ,biobank ,EURACAN ,ITMIG ,microRNA ,TCGA ,thymic carcinoma ,thymic epithelial tumors ,thymoma ,Translational research ,Malignancy ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Methods ,Functional studies ,Thymic carcinoma ,business.industry ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Biobank ,030104 developmental biology ,030220 oncology & carcinogenesis ,Differential diagnosis ,business - Abstract
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas tend to show aggressive behavior and extrathoracic spread. Moreover, the interplay of epithelial cells and thymocytes in thymomas causes complex immune derangement and related systemic autoimmune diseases. Due to their rare occurrence and to the limited funding opportunities available for rare tumors, it is challenging to make advances in clinical and translational research in TET. The authors of this paper are all members of a multidisciplinary clinical and research thoracic tumor team. Strong input was given to the team by long-standing expertise in TET in the Pathology Department. In addition, thanks to the collaboration between research units at our Institute as well as to national collaborations, over the last 10 years we were able to perform several tissue-based research studies. The most recent studies focused on microRNA and on functional studies on the thymic carcinoma cell line 1889c. The recent implementation of our biobank now provides us with a new tool for networking collaborative research activities. Moreover, the participation in a worldwide community such as ITMIG (International Thymic Malignancy Interest Group) has allowed us to significantly contribute toward fundamental projects/research both in tissue-based studies (The Cancer Genome Atlas) and in clinical studies (TNM staging of TET). Our achievements derive from constant commitment and long-standing experience in diagnosis and research in TET. New perspectives opened up due to the establishment of national [the Italian Collaborative Group for ThYmic MalignanciEs (TYME)] and European reference networks such as EURACAN, for an empowered joint clinical action in adult solid rare tumors. The challenge we face still lies in the advancement of clinical and basic science in thymic epithelial malignancies. more...
- Published
- 2020
14. Subxiphoid single-port video-assisted thoracoscopic surgery
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Enrico Melis, Chia-Chuan Liu, Chih-Shiun Shih, Chih-Tao Cheng, Yun-Hen Liu, and Zhen-Ying Liu
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Chylothorax ,Adhesion (medicine) ,030204 cardiovascular system & hematology ,medicine.disease ,Original Article on Subxiphoid Surgery ,Surgery ,03 medical and health sciences ,Dissection ,0302 clinical medicine ,Port (medical) ,030220 oncology & carcinogenesis ,Mediastinal lymph node ,Video-assisted thoracoscopic surgery ,medicine ,Lung cancer ,business ,Wedge resection (lung) - Abstract
Background: We report the feasibility and safety of chest surgery through the subxiphoid single port approach based on our preliminary experience. Methods: From December 2013 till January 2016, 39 patients underwent 40 thoracoscopic surgeries via a 3- to 4-cm subxiphoid single incision. A sternal lifter was applied for better entrance and working angle. A zero-degree deflectable scope was preferred. The technique for anatomic resection was similar to that in the traditional single-port approach. Patient characteristics and demographic data were analyzed. Results: There were 29 females and 10 males, with a median age of 56 years. Indication for surgery included 24 patients with primary lung cancer, eight with lung metastases, two with benign lung lesions, one with bilateral pneumothorax, and five with mediastinal tumors. Surgeries included lobectomy in 21, segmentectomy in five, wedge resection in nine, and mediastinal surgery in five patients. There was no surgical mortality. Complications (10%, 4 in 40) included postoperative bleeding in one patient, chylothorax in one patient, and transient arrhythmia in the early learning curve in two patients. Conclusions: Our results indicated that subxiphoid single-incision thoracoscopic pulmonary resection could be performed safely but under careful patient selection with modification of instruments. Moreover, having a previous single-port incision experience was crucial. Major limitations of this approach included more frequently encountered instrument fighting; interference of left-side procedure related to heartbeat and radical mediastinal lymph node (LN) dissection; and the ability to handle complex conditions, such as anthracotic LNs, diffuse adhesion, and major bleeding. more...
- Published
- 2016
15. Preoperative evaluation of patients undergoing lung resection surgery. defining the role of the anesthesiologist on a multidisciplinary team
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Federico Pierconti, Francesco Facciolo, Cecilia Coccia, Giorgio Della Rocca, Roberto Badagliacca, Maria Papale, Enrico Melis, Carmine Dario Vizza, and Luigi Vetrugno
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Spirometry ,medicine.medical_specialty ,anesthesiology and pain medicine ,medicine.medical_treatment ,MEDLINE ,030204 cardiovascular system & hematology ,Multidisciplinary team ,Preoperative care ,Metabolic equivalent ,03 medical and health sciences ,Pneumonectomy ,Oxygen Consumption ,0302 clinical medicine ,thoracic surgery, thoracic anaesthesia, lung resection, preoperative evaluation, multidisciplinary team, perioperative surgical home ,Preoperative Care ,medicine ,Humans ,Physician's Role ,multidisciplinary team ,Patient Care Team ,medicine.diagnostic_test ,business.industry ,General surgery ,thoracic surgery ,Anesthesiologists ,Surgery ,thoracic anaesthesia ,preoperative evaluation ,cardiology and cardiovascular medicine ,perioperative surgical home ,030228 respiratory system ,Cardiothoracic surgery ,lung resection ,Lung resection ,business - Published
- 2016
16. Long- and Short-Range Ordered Gold Nanoholes as Large-Area Optical Transducers in Sensing Applications
- Author
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Maura Cesaria, Adriano Colombelli, Daniela Lospinoso, Antonietta Taurino, Enrico Melissano, Roberto Rella, and Maria Grazia Manera
- Subjects
unconventional lithography ,ordered nanoholes ,short-range ordered nanoholes ,spectral response ,nanoplasmonics ,refractometric sensing ,Biochemistry ,QD415-436 - Abstract
Unconventional lithography (such as nanosphere lithography (NSL) and colloidal lithography (CL)) is an attractive alternative to sequential and very expensive conventional lithography for the low-cost fabrication of large-area nano-optical devices. Among these, nanohole (NH) arrays are widely studied in nanoplasmonics as transducers for sensing applications. In this work, both NSL and CL are implemented to fabricate two-dimensional distributions of gold NHs. In the case of NSL, highly ordered arrays of gold NHs distributed in a hexagonal lattice onto glass substrates were fabricated by a simple and reproducible approach based on the self-assembling of close-packed 500 nm diameter polystyrene particles at an air/water interface. After the transfer onto a solid substrate, the colloidal masks were processed to reduce the colloidal size in a controllable way. In parallel, CL was implemented with short-range ordered gold NH arrays onto glass substrates that were fabricated by electrostatically-driven self-assembly of negatively charged colloids onto a polydiallyldimethylammonium (PDDA) monolayer. These distributions were optimized as a function of the colloidal adsorption time. For both approaches, controllable and reproducible procedures are presented and discussed. The optical responses of the NH structures are related to the short-range ordering level, and their good performances as refractive index transducers are demonstrated. more...
- Published
- 2019
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17. Fabrication of AlN-Based Flexible Piezoelectric Pressure Sensor to Integrate into an Artificial Pancreas
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Maria Assunta Signore, Chiara De Pascali, Gabriele Rescio, Antonietta Taurino, Paolo Dario, Veronica Iacovacci, Pietro Siciliano, Concetta Martucci, Enrico Melissano, Fabio Quaranta, and Luca Francioso more...
- Subjects
piezoelectric pressure sensor ,AlN thin films ,implantable artificial pancreas ,General Works - Abstract
Present work reports the fabrication and characterization of a flexible AlN-based piezoelectric pressure sensor integrated, as insulin capsule punching detector, into an implantable artificial pancreas (AP), developed as automated treatment device for Type 1 diabetes. Ti/AlN/Ti trilayer was sputtered on a thin kapton substrate at room temperature, making the final device flexible and sensitive to the forces range of interest (0–4 N). The proposed preliminary prototype of AP comprises a refilling module, interfaced with the intestine wall, able to dock an ingestible insulin capsule. A linearly actuated needle punches the capsule to transfer the insulin to an implanted reservoir. The pressure sensor is located at the connection of the needle with the linear actuator to sense the occurred capsule punching. The sensor waveform output was processed to clearly identify the capsule punching. more...
- Published
- 2018
- Full Text
- View/download PDF
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