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506 results on '"Elisseeff, Jennifer"'

1. Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials

Author

Maduka, Chima V., Schmitter-Sánchez, Axel D., Makela, Ashley V., Ural, Evran, Stivers, Katlin B., Pope, Hunter, Kuhnert, Maxwell M., Habeeb, Oluwatosin M., Tundo, Anthony, Alhaj, Mohammed, Kiselev, Artem, Chen, Shoue, Donneys, Alexis, Winton, Wade P., Stauff, Jenelle, Scott, Peter J. H., Olive, Andrew J., Hankenson, Kurt D., Narayan, Ramani, Park, Sangbum, Elisseeff, Jennifer H., and Contag, Christopher H.

Published
2024
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4. Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

Author

Yang, Huilin, Ulge, Umut Y., Quijano-Rubio, Alfredo, Bernstein, Zachary J., Maestas, David R., Chun, Jung-Ho, Wang, Wentao, Lin, Jian-Xin, Jude, Kevin M., Singh, Srujan, Orcutt-Jahns, Brian T., Li, Peng, Mou, Jody, Chung, Liam, Kuo, Yun-Huai, Ali, Yasmin H., Meyer, Aaron S., Grayson, Warren L., Heller, Nicola M., Garcia, K. Christopher, Leonard, Warren J., Silva, Daniel-Adriano, Elisseeff, Jennifer H., Baker, David, and Spangler, Jamie B.

Published
2023
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6. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies

Author

Cherry, Christopher, Andorko, James I., Krishnan, Kavita, Mejías, Joscelyn C., Nguyen, Helen Hieu, Stivers, Katlin B., Gray-Gaillard, Elise F., Ruta, Anna, Han, Jin, Hamada, Naomi, Hamada, Masakazu, Sturmlechner, Ines, Trewartha, Shawn, Michel, John H., Davenport Huyer, Locke, Wolf, Matthew T., Tam, Ada J., Peña, Alexis N., Keerthivasan, Shilpa, Le Saux, Claude Jordan, Fertig, Elana J., Baker, Darren J., Housseau, Franck, van Deursen, Jan M., Pardoll, Drew M., and Elisseeff, Jennifer H.

Published
2023
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9. Age‐associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response.

Author

Han, Jin, Cherry, Christopher, Mejías, Joscelyn C., Krishnan, Kavita, Ruta, Anna, Maestas, David R., Peña, Alexis N., Nguyen, Helen Hieu, Nagaraj, Sushma, Yang, Brenda, Gray‐Gaillard, Elise F., Rutkowski, Natalie, Browne, Maria, Tam, Ada J., Fertig, Elana J., Housseau, Franck, Ganguly, Sudipto, Moore, Erika M., Pardoll, Drew M., and Elisseeff, Jennifer H.

Published
2024
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13. Corneal reshaping: an experiment with a type I collagen-based vitrigel for remodeling porcine corneas.

Author

Carolina Marquezan, Maria, de Freitas, Denise, Majumdar, Shoumyo, Xiaokun Wang, Elisseeff, Jennifer, Guyton, David L., Scot Bower, Kraig, Skurski, Zachary P., Regina Chalita, Maria, Belfort Jr, Rubens, and Jun, Albert S.

Subjects
CORNEA, OPTICAL coherence tomography, CORNEAL topography, EXCIMER lasers, BIOMEDICAL materials
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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16. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Author

Faust, Heather J., Zhang, Hong, Han, Jin, Wolf, Matthew T., Jeon, Ok Hee, Sadtler, Kaitlyn, Pena, Alexis N., Chung, Liam, Maestas, David R., Jr., Tam, Ada J., Pardoll, Drew M., Campisi, Judith, Housseau, Franck, Zhou, Daohong, Bingham, Clifton O., III, and Elisseeff, Jennifer H.

Subjects
Thermo Fisher Scientific Inc., Osteoarthritis -- Health aspects, Cytokines -- Health aspects, Transforming growth factors -- Health aspects, Immune response -- Health aspects, Scientific equipment industry -- Health aspects, T cells -- Health aspects, Health care industry, Johns Hopkins University. School of Medicine
Abstract

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines. In a model of posttraumatic OA (PTOA), anterior cruciate ligament transection (ACLT) induced a type 17 immune response in the articular compartment and draining inguinal lymph nodes (LNs) that paralleled expression of the senescence marker [p16.sup.INK4a] (Cdkn2a) and p21 (Cdkn1a). Innate lymphoid cells, [gamma][delta].sup.+] T cells, and [CD4.sup.+] T ells contributed to IL-17 expression. Intra-articular injection of IL-17-neutralizing antibody reduced joint degeneration and decreased expression of the senescence marker Cdkn1a. Local and systemic senolysis was required to attenuate tissue damage in aged animals and was associated with decreased IL-17 and increased IL-4 expression in the articular joint and draining LNs. In vitro, we found that Th17 cells induced senescence in fibroblasts and that SnCs skewed naive T cells toward Th17 or Th1, depending on the presence of TGF-[beta]. The SASP profile of the inflammation-induced SnCs included altered Wnt signaling, tissue remodeling, and cell-cycle pathways not previously implicated in senescence. These findings provide molecular targets and mechanisms for senescence induction and therapeutic strategies to support tissue healing in an aged environment., Introduction Regenerative medicine strategies aim to promote new tissue development but are often limited by systemic and environmental inhibitory factors such as aging or infection. Cellular senescence is associated with [...]

Published
2020
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22. Senescent cells and osteoarthritis: a painful connection

Author

Jeon, Ok Hee, David, Nathaniel, Campisi, Judith, and Elisseeff, Jennifer H.

Subjects
Osteoarthritis -- Development and progression -- Risk factors -- Care and treatment, Immune response -- Health aspects, Cell aging -- Health aspects -- Causes of, Knee injuries -- Complications and side effects, Health care industry
Abstract

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its incidence increases with age. For years, the presence of SnCs in cartilage isolated from patients undergoing total knee artificial implants has been noted, but these cells' relevance to disease was unclear. In this Review, we summarize current knowledge of SnCs in the multiple tissues that constitute the articular joint. New evidence for the causative role of SnCs in the development of posttraumatic and age-related arthritis is reviewed along with the therapeutic benefit of SnC clearance. As part of their senescence- associated secretory phenotype, SnCs secrete cytokines that impact the immune system and its response to joint tissue trauma. We present concepts of the immune response to tissue trauma as well as the interactions with SnCs and the local tissue environment. Finally, we discuss therapeutic implications of targeting SnCs in treating osteoarthritis., Introduction Osteoarthritis (OA), the most common joint disease of late life, affects 80% of individuals over age 65 (1). Women and obese individuals are more susceptible to this chronic disease [...]

Published
2018
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25. Remodelamento corneano: relato de um experimento com um vitrigel a base de colágeno tipo I para remodelamento de córneas porcinas

Author

Marquezan, Maria Carolina, Freitas, Denise de, Majumdar, Shoumyo, Wang, Xiaokun, Elisseeff, Jennifer, Guyton, David L., Bower, Kraig Scot, Skurski, Zachary P., Chalita, Maria Regina, Belfort Jr, Rubens, and Jun, Albert S.

Subjects
Corneal stroma, Swine, Corneal surgery, Proteses e implantes, Animais, Suínos, Substância própria, Materiais bio-compatíveis, laser, Cornea, Córnea, Prostheses and implants, Lasers de excimer, Animals, Corneal topography, Biocompatible materials, Lasers excimer, Cirurgia da córnea a laser
Abstract

Purpose: This study aimed to report an experiment designed to determine anatomical changes in porcine corneas following placement of a novel polymer implant into the cornea. Methods: An ex vivo porcine eye model was used. A novel type I collagen-based vitrigel implant (6 mm in diameter) was shaped with an excimer laser on the posterior surface to create three planoconcave shapes. Implants were inserted into a manually dissected stromal pocket at a depth of approximately 200 μm. Three treatment groups were defined: group A (n=3), maximal ablation depth 70 μm; Group B (n=3), maximal ablation depth 64 μm; and group C (n=3), maximal ablation depth 104 μm, with a central hole. A control group (D, n=3) was included, in which a stromal pocket was created but biomaterial was not inserted. Eyes were evaluated by optical coherence tomography (OCT) and corneal tomography. Results: Corneal tomography showed a trend for a decreased mean keratometry in all four groups. Optical coherence tomography showed corneas with implants placed within the anterior stroma and visible flattening, whereas the corneas in the control group did not qualitatively change shape. Conclusions: The novel planoconcave biomaterial implant described herein could reshape the cornea in an ex vivo model, resulting in the flattening of the cornea. Further studies are needed using in vivo animal models to confirm such findings. RESUMO Objetivo: Relatar um experimento projetado para determinar alterações anatômicas em córneas porcinas após a colocação de um novo implante de polímero na córnea. Métodos: Foi utilizado olho de porco ex vivo. Um novo agente modelador biocompatível, de colágeno tipo 1, com 6mm de diâmetro foi moldado com excimer laser em sua face posterior, para criar três formatos planocôncavos. Os implantes foram inseridos dentro de um bolsão, dissecado manualmente, a 200 micrômetros (μm). Foram definidos três grupos de tratamento: grupo A (n=3), teve a profundidade máxima de ablação de 70 μm; o grupo B (n=3), profundidade máxima de ablação de 64 μm; e o grupo C (n=3), profundidade máxima de ablação de 104 μm, com buraco central. O grupo controle, D (n=3), foi incluído, com a criação do bolsão estromal, porém sem inserir o material. A avaliação desses olhos foi realizada por tomografia de coerência óptica (OCT) e por tomografia corneana. Resultados: A tomografia corneana mostrou uma tendência para diminuição da ceratometria média em todos os 4 grupos. A tomografia de coerência óptica mostrou córneas com implantes localizados no estroma anterior e aplanamento visível, enquanto as córneas não mudaram qualitativamente o formato no grupo controle. Conclusões: O novo implante de biomaterial planocôncavo descrito aqui foi capaz de remodelar a córnea em modelo de animal ex vivo, resultando no aplanamento corneano. Novos estudos são necessários usando modelos animais in vivo para confirmar tais achados.

Published
2023

28. Senolytic treatment reduces oxidative protein stress in an aging male murine model of post‐traumatic osteoarthritis.

Author

Chin, Alexander F., Han, Jin, Clement, Cristina C., Choi, Younghwan, Zhang, Hong, Browne, Maria, Jeon, Ok Hee, and Elisseeff, Jennifer H.

Subjects
HEAT shock proteins, MALE models, OXIDATIVE stress, KNEE joint, AGING, PROTEOMICS
Abstract

Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro‐regenerative response, but the therapeutic benefit is reduced in aged mice. Increased oxidative stress is a hallmark of advanced age. Therefore, here we investigate whether senolytic treatment differentially affects joint oxidative load in young and aged animals. We find that senolysis by a p53/MDM2 interaction inhibitor, UBX0101, reduces protein oxidative modification in the aged arthritic knee joint. Mass spectrometry coupled with protein interaction network analysis and biophysical stability prediction of extracted joint proteins revealed divergent responses to senolysis between young and aged animals, broadly suggesting that knee regeneration and cellular stress programs are contrarily poised to respond as a function of age. These opposing responses include differing signatures of protein‐by‐protein oxidative modification and abundance change, disparate quantitative trends in modified protein network centrality, and contrasting patterns of oxidation‐induced folding free energy perturbation between young and old. We develop a composite sensitivity score to identify specific key proteins in the proteomes of aged osteoarthritic joints, thereby nominating prospective therapeutic targets to complement senolytics. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Author

Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun, Poon, Yan, David, Nathaniel, Baker, Darren J, van Deursen, Jan M, Campisi, Judith, and Elisseeff, Jennifer H

Subjects
Phenotypes -- Research, Osteoarthritis -- Development and progression, Extracellular matrix -- Research, Aging (Biology) -- Research, Biological sciences, Health
Abstract

Author(s): Ok Hee Jeon [1]; Chaekyu Kim [1, 2]; Remi-Martin Laberge [3, 4]; Marco Demaria [3, 5]; Sona Rathod [1]; Alain P Vasserot [4]; Jae Wook Chung [1]; Do Hun [...]

Published
2017
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32. Mimicking biological functionality with polymers for biomedical applications

Author

Green, Jordan J. and Elisseeff, Jennifer H.

Subjects
Biopolymers -- Health aspects -- Usage, Biomedical engineering -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues., Author(s): Jordan J. Green [1]; Jennifer H. Elisseeff (corresponding author) [1] The footpads of a gecko. The adhesive used by mussels to cling to rocks. The infectivity of a virus. [...]

Published
2016
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35. Creation and preclinical evaluation of a novel mussel-inspired, biomimetic, bioactive bone graft scaffold: direct comparison with Infuse bone graft using a rat model of spinal fusion.

Author

Cottrill, Ethan, Pennington, Zach, Wolf, Matthew T., Dirckx, Naomi, Ehresman, Jeff, Perdomo-Pantoja, Alexander, Rajkovic, Christian, Lin, Jessica, Maestas Jr., David R., Mageau, Ashlie, Lambrechts, Dennis, Stewart, Veronica, Sciubba, Daniel M., Theodore, Nicholas, Elisseeff, Jennifer H., and Witham, Timothy

Published
2023
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