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Your search keyword '"Elena Vaisberg"' showing total 2 results
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2 results on '"Elena Vaisberg"'

1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

Author

Brisdell Hunte, Komal Singh, Robert A. Kastelein, Janet Wagner, Yong-Jun Liu, Yuming Xu, Jing Wang, Robin Lesley, Bianca Blom, Donna Rennick, Sandra Zurawski, Kevin W. Moore, Daniel M. Gorman, Jackie C. Timans, John S. Abrams, Charles H. Hannum, Francesca Zonin, Birgit Oppmann, Tatyana Churakova, Elena Vaisberg, Rene de Waal-Malefyt, Nancy Yu, Felix Vega, Man ru Liu, J. Fernando Bazan, Experimental Immunology, and AII - Inflammatory diseases

Subjects
CD4-Positive T-Lymphocytes, Databases, Factual, Protein subunit, medicine.medical_treatment, Molecular Sequence Data, Immunology, Population, Biology, Interleukin-23, Mice, medicine, Animals, Humans, Immunology and Allergy, Amino Acid Sequence, IL-2 receptor, education, STAT4, education.field_of_study, Interleukins, EBI3, Biological activity, Interleukin-12, Cell biology, Infectious Diseases, Cytokine, Interleukin-23 Subunit p19, Interleukin 12, Cytokines, Sequence Alignment, Sequence Analysis
Abstract

A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23 binds to IL-12R beta 1 but fails to engage IL-12R beta 2; nonetheless, IL-23 activates Stat4 in PHA blast T cells. IL-23 induces strong proliferation of mouse memory (CD4(+)CD45Rb(low)) T cells, a unique activity of IL-23 as IL-12 has no effect on this cell population. Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.

Published
2000

2. IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

Author

Terrill K. McClanahan, Wendy M. Blumenschein, Marilyn Travis, Jonathan M. Gilbert, Jeanine D. Mattson, Rency Rosales, Robert A. Kastelein, Linda Hibbert, Jackie C. Timans, Holger Kanzler, Stefan Pflanz, Elena Vaisberg, Donna Rennick, Rene de Waal Malefyt, Wayne To, Daniel M. Gorman, Janet Wagner, Sandra Zurawski, J. Fernando Bazan, Jeanne Cheung, and Tatyana Churakova

Subjects
CD4-Positive T-Lymphocytes, Protein Conformation, T cell, Molecular Sequence Data, Immunology, Antigen-Presenting Cells, Biology, Minor Histocompatibility Antigens, Interferon-gamma, Interleukin 21, medicine, Cytotoxic T cell, Immunology and Allergy, Amino Acid Sequence, IL-2 receptor, Receptors, Cytokine, Interleukin 27, Antigen-presenting cell, Glutathione Transferase, Glycoproteins, Interleukins, ZAP70, CD28, Receptors, Interleukin, Th1 Cells, Interleukin-12, Cell biology, medicine.anatomical_structure, Infectious Diseases, Carrier Proteins, Dimerization, Sequence Alignment, Cell Division
Abstract

An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.

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