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This volume is based on the Proceedings of the International Conference on'Microbial Infections: Role of Biological Response Modifiers'held in Tampa, FL, May 29-31, 1991. The major purpose of this conference was to bring together in one forum prominent investigators from around the world studying a variety of microbial pathogens, including bacteria, viruses, and fungi, and the effects of biological response modifiers (BRM) on the immune response to these microorganisms. BRM have been widely utilized in the area of antitumor resistance and include not only experimental tumor cell vaccines, but also biologically active substances such as cytokines, i. e., interferons, tumor necrosis factor, and interleukins, as well as products from bacteria which influence host resistance mechanisms. It is the belief of the organizers of this Conference that it was very timely to discuss in detail BRMs as they impact on microbial infections per se. It is now widely accepted that immunocompromised individuals, including those exposed to immunosuppressive substances such as antimetabolites used for chemothera­ py of malignancies, or infectious agents, such as the human immunodeficiency virus and other viruses which depress the immune response and, in turn, affect a host so as to become highly susceptible to opportunistic microorganisms, benefit from BRM stimulation of their immune system. A wide variety of immunomodulators are now being studied in terms of treating infectious diseases, as well as malignancy and autoimmune diseases.

This book represents the seventh edition of what has become an established reference work, MAJOR COMPANIES OF THE FAR EAST & AUSTRALASIA. This volume has been carefully researched and updated since publication of the sixth edition, and provides more company data on the most important companies in the region. The information in the book was submitted mostly by the companies themselves, completely free of charge. For the first time, a third volume has been added to the series, covering major companies in Australia and New Zealand. The companies listed have been selected on the grounds of the size of their sales volume or balance sheet or their importance to the business environment of the country in which they are based. The book will be updated and published every year. Any company that considers it is eligible for inclusion in the next edition of MAJOR COMPANIES OF THE FAR EAST & AUSTRALASIA, should write to the publishers. No charge whatsoever is made for publishing details about a principal Asian company. Whilst the publishers have taken every care to ensure accurate reporting of the company information contained in this book, no liability can be accepted by either the publishers, their editorial staff, or their distributors for any errors or omissions, nor for the consequences thereof.. Graham & Trotman Ltd is a member of the Kluwer Academic Publishers Group and publishes over 450 business and technology books. A catalogue is available on request.

Abstracts of the Sixth International Congress of Pharmacology deals with papers submitted during the pharmacology congress held at Helsinki in 1975. This collection of papers deals with research and development in pharmacology and biotherapeutic drugs. The wide array of subjects deals with the therapeutic implications of controlled drug delivery and the methods of drug application, including pharmacological investigations on cell in a culture. The book also contains papers about the interactions of neurotransmitters and the hypothalamic releasing hormones and toxins as tools in receptor studies. Some papers also deal with behavioral pharmacology that covers drug dependence, narcotic analgesics, and anesthetics. The text explains the method seminar concerning animal models simulating pathological conditions. Other papers discuss the pharmacology of emotive behavior with some volunteer papers dealing with subjects of toxicology, neurochemistry, and clinical psychopharmacology. The book also contains papers on cancer chemotherapy, hypertension, neurochemistry, and hematology. One paper evaluates the effects of cardiovascular drugs in humans. This book is suitable for pharmacologists, drug researchers, micro-chemists, oncologists, and specialists in many fields of medicine.

Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.