17 results on '"Eiji Kozawa"'
Search Results
2. Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
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Takehiro Ota, Yoshihiro Nishida, Kunihiro Ikuta, Satoshi Tsukushi, Kenji Yamada, Eiji Kozawa, Hiroshi Urakawa, and Shiro Imagama
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Medicine ,Science - Abstract
Abstract Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with various demographic factors. Eighty surgically treated patients with intra-articular tumors (knee: 49, ankle and foot: 12, hip: 10, others: 9) were included in this study. Factors including age, disease type (diffuse/localized), location, existence of osteochondral destruction were correlated with local recurrence or development/progression of osteochondral destruction. The 5-year local recurrence free survival rate was 71.4%. Diffuse type (n = 59, localized: n = 21) (P = 0.023) and knee location (P = 0.002) were independent risk factors for local recurrence. Diffuse type (P = 0.009) was a significant risk factor, and knee location (P = 0.001) was a negative factor for osteochondral destruction at the initial examination. Progression of osteochondral destruction was observed more often in cases with local recurrence (P = 0.040) and findings of osteochondral destruction at the initial examination (P = 0.029). Diffuse type is a factor that should be noted for both local recurrence and osteochondral destruction, while local recurrence occurs but osteochondral destruction is less observed in the knee.
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- 2021
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3. Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study
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Hisaki Aiba, Kunihiro Ikuta, Kunihiro Asanuma, Katsuhisa Kawanami, Satoshi Tsukushi, Akihiko Matsumine, Daisuke Ishimura, Akihito Nagano, Yoji Shido, Eiji Kozawa, Kenji Yamada, Junji Wasa, Hiroaki Kimura, Takao Sakai, Hideki Murakami, Tomohisa Sakai, Tomoki Nakamura, and Yoshihiro Nishida
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soft tissue sarcoma ,invasive front ,tail-like lesion ,myxofibrosarcoma ,undifferentiated pleomorphic sarcoma ,neoadjuvant therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The effect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesions was related to the histopathological responses in the main part of the tumor. Complete disappearance of the tail-like lesion was observed in 12 patients; however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with and without the complete disappearance of tail-like lesions. This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy.
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- 2021
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4. Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model
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Yoshitoshi Higuchi, Yoshihiro Nishida, Eiji Kozawa, Lisheng Zhuo, Eisuke Arai, Shunsuke Hamada, Daigo Morita, Kunihiro Ikuta, Koji Kimata, Takahiro Ushida, and Naoki Ishiguro
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Medicine ,Science - Abstract
Abstract The catabolism of hyaluronan in articular cartilage remains unclear. The aims of this study were to investigate the effects of hyaluronidase 2 (Hyal2) knockdown in articular cartilage on the development of osteoarthritis (OA) using genetic manipulated mice. Destabilization of the medial meniscus (DMM) model of Col2a promoter specific conditional Hyal2 knockout (Hyal −/− ) mice was established and examined. Age related and DMM induced alterations of articular cartilage of knee joint were evaluated with modified Mankin score and immunohistochemical staining of MMP-13, ADAMTS-5, KIAA11199, and biotinylated- hyaluronan binding protein staining in addition to histomorphometrical analyses. Effects of Hyal2 suppression were also analyzed using explant culture of an IL-1α induced articular cartilage degradation model. The amount and size of hyaluronan in articular cartilage were higher in Hyal2 −/− mice. Hyal2 −/− mice exhibited aggravated cartilage degradation in age-related and DMM induced mice. MMP-13 and ADAMTS-5 positive chondrocytes were significantly higher in Hyal2 −/− mice. Articular cartilage was more degraded in explant cultures obtained from Hyal2 −/− mice. Knockdown of Hyal2 in articular cartilage induced OA development and progression possibly mediated by an imbalance of HA metabolism. This suggests that Hyal2 knockdown exhibits mucopolysaccharidosis-like OA change in articular cartilage similar to Hyal1 knockdown.
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- 2017
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5. Heat-stimuli-enhanced osteogenesis using clinically available biomaterials.
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Takehiro Ota, Yoshihiro Nishida, Kunihiro Ikuta, Ryuji Kato, Eiji Kozawa, Shunsuke Hamada, Tomohisa Sakai, and Naoki Ishiguro
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Medicine ,Science - Abstract
A recent study reported that heat stress stimulates osteogenesis in an in vivo rat model using alginate gel and magnetite cationic liposomes. However, for clinical use, the efficacy for promoting osteogenesis needs to be investigated using clinically approved materials, and preferably with animals larger than rats. The aim of this study was to evaluate multiple heat stimuli-triggered osteogenesis in rat tibial defect models using already clinically applicable materials (Resovist® and REGENOS®) and determine the efficacy also in the rabbit. Fifty-eight rats and 10 rabbits were divided into two groups, respectively, with or without hyperthermia treatment at 45°C for 15 min. (hyperthermia; 20 rats once a week, 8 rats three times a week, 5 rabbits once a week, control; 30 rats and 5 rabbits). Micro-CT assessment at 4 weeks revealed that a significantly stimulated osteogenesis was observed in the once a week group of both rats and rabbits as compared to the control group (p = 0.018 and 0.036, respectively). In contrast, the three times a week group did not show enhanced osteogenesis. Histological examination and image analysis showed consistent results in which the area of mineralized bone formation in the once a week hyperthermia group was significantly increased compared with that in the control group at four weeks (rat; p = 0.026, rabbit; p = 0.031). Newly formed bone was observed in the grafted materials from the periphery toward the center, and more osteoclasts were found in the once a week group. Heat stress also induced enhanced alkaline phosphatase expression in cultured osteoblastic cells, MC3T3, in vitro (p = 0.03). On the other hand, heat stress had no obvious effects on chondrogenic differentiation using ATDC5 cells. Our study demonstrates that heat-stimuli with clinically applicable novel heating materials can promote significant osteogenesis, and may thus be a promising treatment option for diseases associated with bone defects.
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- 2017
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6. CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: a pilot study.
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Shunsuke Hamada, Naohisa Futamura, Kunihiro Ikuta, Hiroshi Urakawa, Eiji Kozawa, Naoki Ishiguro, and Yoshihiro Nishida
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Medicine ,Science - Abstract
We hypothesized that patterns of CTNNB1 (β-catenin) mutations would affect the outcome of conservative therapy in patients with desmoid tumors. This study aimed to determine the significance of CTNNB1 (β-catenin) mutations in predicting the treatment outcome in patients with desmoid tumors treated with meloxicam, a cyclooxygenase-2 (COX-2) selective inhibitor. Between 2003 and 2012, consecutive thirty-three patients with extra-peritoneal sporadic desmoid tumors were prospectively treated with meloxicam as the initial systemic medical therapy. The efficacy of meloxicam was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST). DNA was isolated from frozen tissue or formalin-fixed materials. CTNNB1 mutation analysis was performed by direct sequencing. Positivity of nuclear β-catenin staining by immunohistochemistry was compared with the status of CTNNB1 mutations. The correlation between the efficacy of meloxicam treatment and status of CTNNB1 mutations was analyzed. Of the 33 patients with meloxicam treatment, one showed complete remission (CR), 7 partial remission (PR), 12 stable disease (SD), and 13 progressive disease (PD). The following 3 point mutations were identified in 21 of the 33 cases (64%): T41A (16 cases), S45F (4 cases) and S45P (one case). The nuclear expression of β-catenin correlated significantly with CTNNB1 mutation status (p = 0.035); all four cases with S45F mutation exhibited strong nuclear expression of β-catenin. S45F mutation was significantly associated with a poor response (all cases; PD) (p = 0.017), whereas the other mutations had no impact on efficacy. The CTNNB1 mutation status was of significant prognostic value for meloxicam treatment in patients with sporadic desmoid tumors.
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- 2014
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7. Clinical Outcome in Patients With High-grade Soft-tissue Sarcoma Receiving Prosthetic Replacement After Tumor Resection of the Lower Extremities: Tokai Musculoskeletal Oncology Consortium Study.
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TOMOKI NAKAMURA, TOMOHISA SAKAI, SATOSHI TSUKUSHI, HIROAKI KIMURA, JUNJI WASA, KOZO HOSONO, YUYA IZUBUCHI, EIJI KOZAWA, AKIHITO NAGANO, KUNIHIRO ASANUMA, AKIHIRO SUDO, and YOSHIHIRO NISHIDA
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SOFT tissue tumors ,DISEASE relapse ,LEG diseases ,ONCOLOGY ,DATA analysis - Abstract
Aim: This multicenter retrospective study aimed to clarify the surgical and oncological outcomes of patients with high-grade soft tissue sarcoma (STS) who underwent prosthetic replacement reconstruction after lower extremity tumor resection. Patients and Methods: We retrospectively collected the data of 27 patients with high-grade STS. The mean follow-up duration after prosthetic replacement was 44.7 months. Results: The mean age at surgery was 63 years. The mean tumor size was 16 cm. For reconstruction, proximal femur replacement was performed in 15 patients, distal femur replacement in six, and total femur replacement in six. The major complications were infections in nine patients and aseptic loosening in four. Nine patients developed local recurrence. The cause of revision surgery was infection in five patients, aseptic loosening in three, and metal allergy in one. The 5-year prosthetic survival rate was 51.1%. At the final follow-up, amputation was performed in five patients. The 5-year limb salvage rate was 76.8%. The mean functional score of the 25 patients who could be assessed was 16.0 (53%). Of the 27 patients, five were excluded from the survival analysis because they underwent prosthetic replacement for local recurrence. The 5-year overall survival rate in the remaining 22 patients was 45.3%. Conclusion: We identified a high rate of surgical complications and poor survival in patients with high-grade STS who underwent tumor resection and reconstruction using prosthetic replacement of the lower extremities, although limb salvage was achieved in 81.5% of the patients. Careful follow-up is needed for surgical complications and oncological events after surgery. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection
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Satoshi Tsukushi, Daisuke Ishimura, Noriaki Sakakura, Yukinori Sakao, Takuma Hayashi, Harumoto Yamada, Masahiro Yoshida, and Eiji Kozawa
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Vital capacity ,medicine.medical_treatment ,Pulmonary function testing ,03 medical and health sciences ,Pneumonectomy ,0302 clinical medicine ,surgical complication ,pulmonary function test ,medicine ,thoracic sarcoma ,chest wall tumor ,Pneumonitis ,Rib cage ,Lung ,business.industry ,Cancer ,thoracic cage reconstruction ,Articles ,medicine.disease ,Surgery ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,business ,Thoracic wall - Abstract
Postoperative complications of thoracic wall resection include respiratory complications, skin necrosis and infection. The aim of the present study was to examine postoperative complications in patients who required combined thoracic wall resection during the surgical removal of a tumor. The present study included 68 patients; there were 50 patients with lung tumors and 18 patients with musculoskeletal tumors. The clinical factors associated with complications were compared between the two groups. Preoperative and postoperative pulmonary function tests were performed to examine the residual pulmonary function in 16 patients. Thoracic cage reconstruction was performed in 46 patients. Postoperative complications occurred in 30 (44.1%) patients, and one patient died from postoperative pneumonitis. Compared with the pulmonary function preoperative test results, the postoperative results revealed a decrease in the mean vital capacity percentage and an increase in the mean forced expiratory volume within 1 sec as a percent of the forced vital capacity. In patients with lung tumors, pneumonectomy can result in an increased rate of complications following thoracic wall resection. Residual pulmonary function is affected by impaired thoracic cage expansion and removal of the lung. However, the results of the present study demonstrated that these complications can be somewhat stabilized by thoracic wall reconstruction.
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- 2019
9. CTNNB1 S45F Mutation Predicts Poor Efficacy of Meloxicam Treatment for Desmoid Tumors: A Pilot Study
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Hiroshi Urakawa, Naoki Ishiguro, Naohisa Futamura, Yoshihiro Nishida, Eiji Kozawa, Kunihiro Ikuta, and Shunsuke Hamada
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Male ,Pathology ,Thiazines ,lcsh:Medicine ,Pilot Projects ,medicine.disease_cause ,Meloxicam ,Gastroenterology ,Medicine and Health Sciences ,lcsh:Science ,Child ,beta Catenin ,Mutation ,Multidisciplinary ,Fibromatosis ,Sarcomas ,Middle Aged ,Fibromatosis, Aggressive ,Treatment Outcome ,Oncology ,Response Evaluation Criteria in Solid Tumors ,Immunohistochemistry ,Female ,medicine.drug ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,Antineoplastic Agents ,Fibromatosis, Abdominal ,Young Adult ,Pharmacotherapy ,Diagnostic Medicine ,Internal medicine ,medicine ,Humans ,Point Mutation ,Aged ,Retrospective Studies ,Cell Nucleus ,business.industry ,Point mutation ,lcsh:R ,Cancers and Neoplasms ,medicine.disease ,Thiazoles ,lcsh:Q ,Clinical Medicine ,business ,Progressive disease - Abstract
We hypothesized that patterns of CTNNB1 (β-catenin) mutations would affect the outcome of conservative therapy in patients with desmoid tumors. This study aimed to determine the significance of CTNNB1 (β-catenin) mutations in predicting the treatment outcome in patients with desmoid tumors treated with meloxicam, a cyclooxygenase-2 (COX-2) selective inhibitor. Between 2003 and 2012, consecutive thirty-three patients with extra-peritoneal sporadic desmoid tumors were prospectively treated with meloxicam as the initial systemic medical therapy. The efficacy of meloxicam was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST). DNA was isolated from frozen tissue or formalin-fixed materials. CTNNB1 mutation analysis was performed by direct sequencing. Positivity of nuclear β-catenin staining by immunohistochemistry was compared with the status of CTNNB1 mutations. The correlation between the efficacy of meloxicam treatment and status of CTNNB1 mutations was analyzed. Of the 33 patients with meloxicam treatment, one showed complete remission (CR), 7 partial remission (PR), 12 stable disease (SD), and 13 progressive disease (PD). The following 3 point mutations were identified in 21 of the 33 cases (64%): T41A (16 cases), S45F (4 cases) and S45P (one case). The nuclear expression of β-catenin correlated significantly with CTNNB1 mutation status (p = 0.035); all four cases with S45F mutation exhibited strong nuclear expression of β-catenin. S45F mutation was significantly associated with a poor response (all cases; PD) (p = 0.017), whereas the other mutations had no impact on efficacy. The CTNNB1 mutation status was of significant prognostic value for meloxicam treatment in patients with sporadic desmoid tumors.
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- 2014
10. Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice
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Guo-Ping Shi, Masafumi Kuzuya, Eiji Kozawa, Lina Hu, Xian Wu Cheng, Haiying Jiang, Aiko Inoue, Kenji Okumura, Xiang Li, and Haizhen Song
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Male ,medicine.medical_specialty ,Chemokine ,Pathology ,Cathepsin K ,Inflammation ,Article ,Muscle, Smooth, Vascular ,Lesion ,Mice ,Internal medicine ,Internal Medicine ,medicine ,Animals ,Cell Proliferation ,Neointimal hyperplasia ,Mice, Knockout ,biology ,Cell growth ,Monocyte ,medicine.disease ,Disease Models, Animal ,medicine.anatomical_structure ,Endocrinology ,Collagenase ,biology.protein ,medicine.symptom ,Carotid Artery Injuries ,medicine.drug - Abstract
Cathepsin K (CatK) is one of the most potent mammalian collagenases. We showed previously the increased expression of CatK in human and animal atherosclerotic lesions. Here, we hypothesized that ablation of CatK mitigates injury-induced neointimal hyperplasia. Male wild-type (CatK +/+ ) and CatK-deficient (CatK −/− ) mice underwent ligation or a combination of ligation and polyethylene cuff-replacement injuries to the right common carotid artery just proximal to its bifurcation, and they were then processed for morphological and biochemical studies at specific time points. On operative day 28, CatK −/− significantly reduced neointimal formation and neovessel formation in both single- and combination-injured arteries compared with the Cat K +/+ mice. At early time points, CatK −/− reduced the lesion macrophage contents and medial smooth muscle cell proliferation, the mRNA levels of monocyte chemoattractant protein-1, toll-like receptor-2, toll-like receptor-4, chemokine ligand-12, and the gelatinolytic activity related to matrix metalloproteinase-2/-9. An aorta-explant assay revealed that smooth muscle cell movement was impaired in the CatK −/− mice compared with the CatK +/+ mice. In addition, the smooth muscle cells and macrophages from CatK −/− mice had less invasive ability through a reconstituted basement membrane barrier. This vasculoprotective effect was mimicked by Cat inhibition with trans -epoxysuccinyl-L-leucylamido-{4-guanidino} butane (E64 d ). These results demonstrate an essential role of CatK in neointimal lesion formation in response to injury, possibly via the reduction of toll-like receptor-2/-4–mediated inflammation and smooth muscle cell proliferation, suggesting a novel therapeutic strategy for the control of endovascular treatment–related restenosis by regulating CatK activity.
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- 2013
11. Clinical factors affecting pathological fracture and healing of unicameral bone cysts
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Satoshi Tsukushi, Naohisa Futamura, Kenji Yamada, Naoki Ishiguro, Hideshi Sugiura, Eiji Kozawa, Hiroshi Urakawa, Yoshihisa Yamada, Kozo Hosono, Eisuke Arai, and Yoshihiro Nishida
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Healing ,medicine.medical_treatment ,Long bone ,Unicameral bone cyst ,Clinical factors ,Lytic Bone Lesion ,Fractures, Bone ,Young Adult ,Rheumatology ,Risk Factors ,Biopsy ,medicine ,Bone Cysts ,Humans ,Orthopedics and Sports Medicine ,Humerus ,Cyst ,Child ,Pathological ,Retrospective Studies ,Fracture Healing ,medicine.diagnostic_test ,business.industry ,fungi ,Pathological fracture ,Middle Aged ,medicine.disease ,Prognosis ,Surgery ,Radiography ,medicine.anatomical_structure ,Child, Preschool ,Female ,business ,Watchful waiting ,Research Article ,Follow-Up Studies - Abstract
Background Unicameral bone cyst (UBC) is the most common benign lytic bone lesion seen in children. The aim of this study is to investigate clinical factors affecting pathological fracture and healing of UBC. Methods We retrospectively reviewed 155 UBC patients who consulted Nagoya musculoskeletal oncology group hospitals in Japan. Sixty of the 155 patients had pathological fracture at presentation. Of 141 patients with follow-up periods exceeding 6 months, 77 were followed conservatively and 64 treated by surgery. Results The fracture risk was significantly higher in the humerus than other bones. In multivariate analysis, ballooning of bone, cyst in long bone, male sex, thin cortical thickness and multilocular cyst were significant adverse prognostic factors for pathological fractures at presentation. The healing rates were 30% and 83% with observation and surgery, respectively. Multivariate analysis revealed that fracture at presentation and history of biopsy were good prognostic factors for healing of UBC in patients under observation. Conclusion The present results suggest that mechanical disruption of UBC such as fracture and biopsy promotes healing, and thus watchful waiting is indicated in these patients, whereas patients with poor prognostic factors for fractures should be considered for surgery.
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- 2014
12. Simple resection of truncal desmoid tumors: A case series.
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YOSHIHIRO NISHIDA, SATOSHI TSUKUSHI, HIROSHI URAKAWA, SHUNSUKE HAMADA, EIJI KOZAWA, KUNIHIRO IKUTA, and NAOKI ISHIGURO
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DESMOID tumors ,CATENIN genetics ,MESENCHYMAL stem cells ,CANCER invasiveness ,CYCLOOXYGENASES - Abstract
Desmoid tumors of the extra-abdominal and abdominal wall have been associated with morbidity due to the aggressive nature of the surgery and high recurrence rates. Surgery that does not cause functional impairment is desired for patients with desmoid tumors. In the present study, among patients with desmoid tumors who were prospectively and consecutively treated with identical conservative treatment with meloxicam, a selected patients of patients were treated with less invasive surgery than wide-resection. Out of 60 patients pathologically diagnosed with desmoid tumors, 9 patients with tumors refractory to conservative treatment and 4 patients who refused to receive this type of treatment were treated with planned simple resection. Subsequently, the clinical outcome of the patients and the mutational status of the catenin β-1 (CTNNB1) gene in the tumors were analyzed. The mean age of the 13 patients that underwent planned simple resection was 39 years, and the tumors were located in the abdominal wall in 6 cases, the chest wall in 4 cases and the neck in 3 cases. All excised specimens were evaluated and positive microscopic margins were identified; however, during the mean follow-up period of 30 months, 12/13 cases, 7 of which had T41A mutations and 5 of which had no mutations (wild-type), did not develop recurrence. Only 1 initial case with an S45F mutation in the CTNNB1 gene developed recurrence. The results of the present prospectively treated with simple resection and retrospectively analyzed study suggest that planned simple resection could serve as a therapeutic modality for extraperitoneal desmoid tumors, particular truncal ones with a wild.type or T41A mutational status. [ABSTRACT FROM AUTHOR]
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- 2016
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13. Giant cell tumor of bone arising in long bones possibly originates from the metaphyseal region.
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NAOHISA FUTAMURA, HIROSHI URAKAWA, SATOSHI TSUKUSHI, EISUKE ARAI, EIJI KOZAWA, NAOKI ISHIGURO, and YOSHIHIRO NISHIDA
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GIANT cell tumors ,BONE tumors ,OSTEORADIOGRAPHY ,FEMUR ,GROWTH plate ,ANATOMY - Abstract
Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of radiographic examination. For that purpose, plain X-ray scans of 71 GCTBs arising in long bones were retrospectively reviewed. The tumor locations were the distal femur in 31 cases, proximal femur in 11 cases, proximal tibia in 13 cases, distal radius in 6 cases, proximal humerus in 5 cases and proximal fibula in 5 cases. The vertical center (VC) of the tumor was determined with X-ray anteroposterior view, and the correlation between the VC and the epiphyseal line, and between the distance from the epiphyseal line to the VC and tumor area or volume were analyzed using a regression model equation based on scatter plot diagrams. The VC of the tumor was located in the metaphyseal region in 57 cases, in the epiphyseal line in 11 cases and in the epiphyseal region in 3 cases. In cases of GCTB located in the distal femur or proximal tibia, significant correlations between the distance from the VC to the epiphyseal line and tumor area or volume were identified. The site of origin of GCTB was estimated to be located in the metaphyseal region. GCTB often occurs in mature patients, which renders it challenging to estimate the true site of origin of this lesion, since the metaphyseal line has disappeared in mature patients. The results of the present study suggest that GCTB possibly originates in the metaphyseal region. [ABSTRACT FROM AUTHOR]
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- 2016
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14. Association of Short Duration From Initial Symptoms to Specialist Consultation With Poor Survival in Soft-Tissue Sarcomas.
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Hiroshi Urakawa, Satoshi Tsukushi, Eisuke Arai, Eiji Kozawa, Naohisa Futamura, Naoki Ishiguro, and Yoshihiro Nishida
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- 2015
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15. Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients.
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HIROSHI URAKAWA, SATOSHI TSUKUSHI, HIDESHI SUGIURA, KENJI YAMADA, YOSHIHISA YAMADA, EIJI KOZAWA, EISUKE ARAI, NAOHISA FUTAMURA, NAOKI ISHIGURO, and YOSHIHIRO NISHIDA
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BONE cancer treatment ,DOXORUBICIN ,IFOSFAMIDE ,SARCOMA ,ADJUVANT treatment of cancer ,CANCER treatment ,THERAPEUTICS - Abstract
. The present study investigated the safety and efficacy of neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcoma in adult and older patients. A total of 18 consecutive patients with bone sarcoma (American Joint Committee on Cancer stage II in 14 patients and stage IV in four) treated with neoadjuvant and adjuvant chemotherapy at Nagoya Musculoskeletal Oncology Group hospitals in Japan between 2004 and 2011 were reviewed. The treatment efficacy and side-effects were evaluated. The responses to neoadjuvant chemotherapy were stable disease in 11 patients and progressive disease in three. Among the 12 evaluable patients, there were five with ≥90% tumor necrosis. The estimated overall survival (OS) rate at five years for the patients without metastasis prior to treatment was 56%. Major grade 3 or 4 side-effects included leukopenia in 14 cases, anemia in seven, thrombocytopenia in three, nausea in two and febrile neutropenia in two. One patient discontinued chemotherapy due to a temporarily depressed level of consciousness with arrhythmia (grade 2). The estimated five-year OS rate in this study was acceptable in patients without metastasis prior to treatment. A better coordinated prospective study of this combination regimen for older patients with bone sarcoma will be required to clarify its efficacy and tolerability. [ABSTRACT FROM AUTHOR]
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- 2014
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16. Subchondral Fracture of the Femoral Head in a High School Badminton Player: A Case Report.
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Hiroshi Urakawa, Yukiharu Hasegawa, Satoshi Tsukushi, Taisuke Seki, Eiji Kozawa, Naoki Ishiguro, and Yoshihiro Nishida
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FEMUR injuries ,HIP fractures ,HIP joint injuries ,BONE density - Abstract
The article describes the case of a 16-year-old teenage boy with a history of right hip pain and inability to walk for a long distance, and diagnosed with subchondral insufficiency fracture of the femoral head. The diagnosis was confirmed after performing physical examination, bone mineral density (BMD) test, radiography, computed tomography (CT) and magnetic resonance imaging (MRI). A review of other reports of patients with subchondral fractures of the femoral head is offered.
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- 2015
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17. Solitary bone metastasis as the first clinical manifestation in a patient with small bowel adenocarcinoma.
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Kenji Yamada, Yuzuru Ikehara, Hayao Nakanishi, Eiji Kozawa, Masae Tatematsu, and Hideshi Sugiura
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- 2007
- Full Text
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