8 results on '"Eigil Fossum"'
Search Results
2. The Full Revasc (Ffr-gUidance for compLete non-cuLprit REVASCularization) Registry-based randomized clinical trial
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Stefan James, Oskar Angerås, Andreas Rück, Carl Schultz, Andrejs Ērglis, Mika Laine, Ollie Östlund, Madhav Menon, Brynjölfur Mogensen, Christoph Liebetrau, Thomas Engstrøm, Felix Böhm, Eigil Fossum, Goran Stankovic, Claes Held, Colin Berry, HUS Heart and Lung Center, and Verisuonikirurgian yksikkö
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Male ,Emergency Medical Services ,medicine.medical_treatment ,Fractional flow reserve ,030204 cardiovascular system & hematology ,Coronary Angiography ,GUIDELINES ,Severity of Illness Index ,ANGIOGRAPHY ,DISEASE ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,FRACTIONAL FLOW RESERVE ,Clinical endpoint ,Medicine ,Cardiac and Cardiovascular Systems ,030212 general & internal medicine ,Registries ,Kardiologi ,Middle Aged ,3. Good health ,Fractional Flow Reserve, Myocardial ,Outcome and Process Assessment, Health Care ,Surgery, Computer-Assisted ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Revascularization ,Culprit ,LESION ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,Humans ,cardiovascular diseases ,Mortality ,ANGIOPLASTY ,Aged ,business.industry ,Coronary Stenosis ,ELEVATION MYOCARDIAL-INFARCTION ,Percutaneous coronary intervention ,medicine.disease ,3126 Surgery, anesthesiology, intensive care, radiology ,Stenosis ,3121 General medicine, internal medicine and other clinical medicine ,Conventional PCI ,ST Elevation Myocardial Infarction ,business - Abstract
Publisher Copyright: © 2021 Background: Complete revascularization in ST elevation myocardial infarction (STEMI) patients with multivessel disease has resulted in reduction in composite clinical endpoints in medium sized trials. Only one trial showed an effect on hard clinical endpoints, but the revascularization procedure was guided by angiographic evaluation of stenosis severity. Consequently, it is not clear how Fractional Flow Reserve (FFR)-guided percutaneous coronary intervention (PCI) affects hard clinical endpoints in STEMI. Methods and Results: The Ffr-gUidance for compLete non-cuLprit REVASCularization (FULL REVASC) – is a pragmatic, multicenter, international, registry-based randomized clinical trial designed to evaluate whether a strategy of FFR-guided complete revascularization of non-culprit lesions, reduces the combined primary endpoint of total mortality, non-fatal MI and unplanned revascularization. 1,545 patients were randomized to receive FFR-guided PCI during the index hospitalization or initial conservative management of non-culprit lesions. We found that in angiographically severe non-culprit lesions of 90-99% severity, 1 in 5 of these lesions were re-classified as non-flow limiting by FFR. Considering lesions of intermediate severity (70%-89%), half were re-classified as non-flow limiting by FFR. The study is event driven for an estimated follow-up of at least 2.75 years to detect a 9.9%/year>7.425%/year difference (HR = 0.74 at 80% power (α = .05)) for the combined primary endpoint. Conclusion: This large randomized clinical trial is designed and powered to evaluate the effect of complete revascularization with FFR-guided PCI during index hospitalization on total mortality, non-fatal MI and unplanned revascularization following primary PCI in STEMI patients with multivessel disease. Enrollment completed in September 2019 and follow-up is ongoing.
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- 2021
3. Eligibility for renal denervation: experience at 11 European expert centers
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Alexandre Persu, Yu Jin, Marie Baelen, Eva Vink, Willemien L. Verloop, Bernhard Schmidt, Marie K. Blicher, Francesca Severino, Grégoire Wuerzner, Alison Taylor, Antoinette Pechère-Bertschi, Fadi Jokhaji, Fadl Elmula M. Fadl Elmula, Jan Rosa, Danuta Czarnecka, Georg Ehret, Thomas Kahan, Jean Renkin, Jiří Widimský, Lotte Jacobs, Wilko Spiering, Michel Burnier, Patrick B. Mark, Jan Menne, Michael H. Olsen, Peter J. Blankestijn, Sverre Kjeldsen, Michiel L. Bots, Jan A. Staessen, Bernhard Gerber, Sandrine Horman, Joëlle Kefer, Jean-Philippe Lengelé, Jean-Benoit le Polain de Waroux, Christophe Scavée, Jean-Louis Vanoverschelde, Antoinette Péchère-Bertschi, Collin Berry, Adrian Brady, Christian Delles, Anna Dominiczak, Marie Freel, Alan Jardine, Jon Moss, Scot Muir, Patrick Mark, Sandosh Padmanabhan, Giles Roditi, Johann Bauersachs, Julia Brinkmann, Hermann Haller, Karsten Heusser, Jens Jordan, Gunnar Klein, Jens Tank, D. Czarnecka, Marek Jastrzębski, Katarzyna Styczkiewicz, Kei Asayama, Yumei Gu, Asuza Hashimoto, Tatiana Kuznetsova, Yanping Liu, Lutgarde Thijs, Maria Blicher, Henning Beck-Nielse, Poul Flemming Høilund-Carlsen, M. Olsen, Magne Brekke, Kristian Engeseth, Eigil Fossum, Eivind Gjønnæss, Ulla Hjørnholm, Pavel Hoffmann, Aud Høieggen, Vibeke Kjær, Sverre E. Kjeldsen, Anne C.K. Larstorp, Oliver Meyerdierks, Ingrid Os, Morten Rostrup, Aud Stenehjem, Ondrej Petrak, Tomas Zelinka, Branislav Strauch, Karol Curila, Petr Tousek, Petr Widimský, Riker Lander, Jonas Spaak, Pieter A. Doevendans, Maarten B. Rookmaaker, Eva E. Vink, Michiel Voskuil, Evert-jan Vonken, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, and UCL - (SLuc) Service de pathologie cardiovasculaire
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Resistant hypertension ,Kidney ,Internal medicine ,Internal Medicine ,medicine ,Hypertension/physiopathology/surgery ,Humans ,Sympathectomy ,Referral and Consultation ,Antihypertensive Agents ,Aged ,Denervation ,ddc:616 ,Arterial anatomy ,business.industry ,Sympathetic Denervation ,Middle Aged ,Confidence interval ,3. Good health ,Surgery ,Europe ,medicine.anatomical_structure ,Blood pressure ,Logistic Models ,Hypertension Resistant to Conventional Therapy ,Hypertension ,Kidney/innervation ,Referral and Consultation/statistics & numerical data ,Female ,Sympathectomy/methods ,business ,After treatment - Abstract
Based on the SYMPLICITY studies and CE (Conformité Européenne) certification, renal denervation is currently applied as a novel treatment of resistant hypertension in Europe. However, information on the proportion of patients with resistant hypertension qualifying for renal denervation after a thorough work-up and treatment adjustment remains scarce. The aim of this study was to investigate the proportion of patients eligible for renal denervation and the reasons for noneligibility at 11 expert centers participating in the European Network COordinating Research on renal Denervation in treatment-resistant hypertension (ENCOReD). The analysis included 731 patients. Age averaged 61.6 years, office blood pressure at screening was 177/96 mm Hg, and the number of blood pressure-lowering drugs taken was 4.1. Specialists referred 75.6% of patients. The proportion of patients eligible for renal denervation according to the SYMPLICITY HTN-2 criteria and each center's criteria was 42.5% (95% confidence interval, 38.0%-47.0%) and 39.7% (36.2%-43.2%), respectively. The main reasons of noneligibility were normalization of blood pressure after treatment adjustment (46.9%), unsuitable renal arterial anatomy (17.0%), and previously undetected secondary causes of hypertension (11.1%). In conclusion, after careful screening and treatment adjustment at hypertension expert centers, only ≈40% of patients referred for renal denervation, mostly by specialists, were eligible for the procedure. The most frequent cause of ineligibility (approximately half of cases) was blood pressure normalization after treatment adjustment by a hypertension specialist. Our findings highlight that hypertension centers with a record in clinical experience and research should remain the gatekeepers before renal denervation is considered. ispartof: Hypertension vol:63 issue:6 pages:1319-25 ispartof: location:United States status: published
- Published
- 2014
4. Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)
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Jens Aarøe, Petteri Kosonen, Thomas Kellerth, Per Thayssen, Matti Niemelä, Kari Niemelä, Jan Harnek, Kari Saunamäki, Saila Vikman, Lisette Okkels Jensen, Andrejs Erglis, Leif Thuesen, Mikko Pietilä, Lars Hellsten, Eigil Fossum, Göran K. Olivecrona, Kari Kervinen, Jens Flensted Lassen, and Antti Ylitalo
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Baltic States ,Male ,medicine.medical_specialty ,Stent thrombosis ,medicine.medical_treatment ,Scandinavian and Nordic Countries ,Intravascular ultrasound ,Coronary stent ,medicine ,Humans ,Bare metal ,Bare metal stents ,Prospective Studies ,Registries ,cardiovascular diseases ,Ultrasonography, Interventional ,Aged ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,Stent ,Drug-Eluting Stents ,Thrombosis ,Incomplete stent apposition ,Middle Aged ,Drug eluting stents ,equipment and supplies ,Surgery ,Treatment Outcome ,surgical procedures, operative ,Metals ,Drug-eluting stent ,Equipment Failure ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background This prospective multicenter registry used intravascular ultrasound (IVUS) in patients with definite stent thrombosis (ST) to compare rates of incomplete stent apposition (ISA), stent fracture and stent expansion in patients treated with drug-eluting (DES) versus bare metal (BMS) stents. ST is a rare, but potential life threatening event after coronary stent implantation. The etiology seems to be multifactorial. Methods 124 patients with definite ST were assessed by IVUS during the acute ST event. The study was conducted in 15 high-volume percutaneous coronary intervention -centers in the Nordic–Baltic countries. Results In early or late ST there were no differences in ISA between DES and BMS. In very late ST, ISA was a more frequent finding in DES than in BMS (52% vs.16%; p=0.005) and the maximum ISA area was larger in DES compared to BMS (1.1±2.3mm 2 vs. 0.1±0.5mm 2 ; p=0.004). Further, ISA was more prevalent in sirolimus-eluting than in paclitaxel-eluting stents (58% vs. 37%; p=0.02). Stent fractures were found both in DES (16%) and BMS (24%); p=0.28, and not related to time of stent thrombosis occurrence. For stents with nominal diameters ≥2.75mm, 38% of the DES and 22% of the BMS had a minimum stent area of less than 5mm 2 ; p=0.14. Conclusions Very late stent thrombosis was more prevalent and associated with more extensive ISA in DES than in BMS treated patients. Stent fracture was a common finding in ST after DES and BMS implantation.
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- 2012
5. Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy.
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Michael H Olsen, Eigil Fossum, Aud Hieggen, Kristian Wachtell, Elsa Hjerkinn, Shawna D Nesbitt, Ulrik B Andersen, Robert A Phillips, Cynthia L Gaboury, Hans Ibsen, Sverre E Kjeldsen, and Stevo Julius
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- 2005
- Full Text
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6. Relations between insulin sensitivity, fitness and autonomic cardiac regulation in healthy, young men.
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Henrik M Reims, Knut Sevre, Eigil Fossum, Aud Hieggen, Harald Mellem, and Sverre E Kjeldsen
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- 2004
- Full Text
- View/download PDF
7. Chronic Occlusion of the Left Main Coronary Artery: Importance of Collaterals.
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Eritsland, Jan and Eigil Fossum
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ARTERIAL occlusions , *CORONARY arterial radiography , *HEART failure , *CORONARY artery bypass , *ANGINA pectoris , *DIAGNOSIS - Abstract
Chronic occlusion of the left coronary artery is an infrequent finding in patients undergoing coronary angiography. These patients usually present symptoms of angina or heart failure. We describe a patient who was training regularly without cardiac symptoms until ventricular fibrillation suddenly occurred during a long-distance run. A chronic left main stem occlusion with well-developed right-to-left coronary collaterals was demonstrated by angiography. Up to this event, the collateral flow had been sufficient to allow physical exercise at a high performance level without symptoms. The patient later underwent coronary bypass surgery and recovered completely. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2010
- Full Text
- View/download PDF
8. Prospective Randomized Optical Coherence Tomography Oslo tRial (PROCTOR)
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Eigil Fossum, MD, PhD
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- 2019
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