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3 results on '"Ehlers, Cordula"'

1. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

Author

Lange, Christoph, Abubakar, Ibrahim, Alffenaar, Jan-Willem C, Bothamley, Graham, Caminero, Jose A, Carvalho, Anna Cristina C, Chang, Kwok-Chiu, Codecasa, Luigi, Correia, Ana, Crudu, Valeriu, Davies, Peter, Dedicoat, Martin, Drobniewski, Francis, Duarte, Raquel, Ehlers, Cordula, Erkens, Connie, Goletti, Delia, Günther, Gunar, Ibraim, Elmira, Kampmann, Beate, Kuksa, Liga, de Lange, Wiel, van Leth, Frank, van Lunzen, Jan, Matteelli, Alberto, Menzies, Dick, Monedero, Ignacio, Richter, Elvira, Rüsch-Gerdes, Sabine, Sandgren, Andreas, Scardigli, Anna, Skrahina, Alena, Tortoli, Enrico, Volchenkov, Grigory, Wagner, Dirk, van der Werf, Marieke J, Williams, Bhanu, Yew, Wing-Wai, Zellweger, Jean-Pierre, Cirillo, Daniela Maria, and TBNET

Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.

Published
2014

2. Pregnancy in patients with tuberculosis: a TBNET cross-sectional survey.

Author

Bothamley, Graham H., Ehlers, Cordula, Salonka, Irina, Skrahina, Alena, Orcau, Angels, Codecasa, Luigi R., Ferrarese, Maurizio, Pesut, Dragica, Solovic, Ivan, Dudnyk, Andrii, Anibarro, Luis, Denkinger, Claudia, Guglielmetti, Lorenzo, Muylle, Inge, and Confalonieri, Marco

Subjects
*TUBERCULOSIS, *PREGNANCY, *DIAGNOSIS, *POSTNATAL care, *MEDICAL care
Abstract

Background: Objectives: To determine whether the incidence of tuberculosis with pregnancy is more common than would be expected from the crude birth rate; to see whether there is significant delay in the diagnosis of tuberculosis during pregnancy. Method: Design: A cross-sectional survey. Setting: 13 tuberculosis clinics within different European countries and the USA. Population/sample: All patients with tuberculosis seen at these clinics for a period < 1 year. Instrument: Questionnaire survey based on continuous data collection. Main outcome measures: number and proportion of women with tuberculosis who were pregnant; timing of diagnosis in relation to pregnancy, including those who were pregnant or delivered in the 3 months prior to the diagnosis of TB and those who developed TB within 3 months after delivery. Results: Pregnancy occurred in 224 (1.5 %) of 15,217 TB patients and followed the expected rate predicted from the crude birth rate for the clinic populations. TB was diagnosed more commonly in the 3 months after delivery (n = 103) than during pregnancy (n = 68; χ2 = 25.1, P < 0.001). Conclusions: TB is diagnosed more frequently after delivery, despite variations in local TB incidence and healthcare systems. [ABSTRACT FROM AUTHOR]

Published
2016
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3. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement.

Author

Lange C, Abubakar I, Alffenaar JW, Bothamley G, Caminero JA, Carvalho AC, Chang KC, Codecasa L, Correia A, Crudu V, Davies P, Dedicoat M, Drobniewski F, Duarte R, Ehlers C, Erkens C, Goletti D, Günther G, Ibraim E, Kampmann B, Kuksa L, de Lange W, van Leth F, van Lunzen J, Matteelli A, Menzies D, Monedero I, Richter E, Rüsch-Gerdes S, Sandgren A, Scardigli A, Skrahina A, Tortoli E, Volchenkov G, Wagner D, van der Werf MJ, Williams B, Yew WW, Zellweger JP, and Cirillo DM

Subjects
Case Management, Clinical Trials as Topic, Communicable Disease Control, Consensus, Disease Management, Disease-Free Survival, Europe, Extensively Drug-Resistant Tuberculosis epidemiology, Extensively Drug-Resistant Tuberculosis prevention & control, Geography, Humans, Infectious Disease Medicine standards, Public Health, Recurrence, Treatment Outcome, Tuberculosis, Multidrug-Resistant epidemiology, Tuberculosis, Multidrug-Resistant prevention & control, World Health Organization, Antitubercular Agents therapeutic use, Extensively Drug-Resistant Tuberculosis therapy, Tuberculosis, Multidrug-Resistant therapy
Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking., (©ERS 2014.)

Published
2014
Full Text
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