49 results on '"Egmond, E."'
Search Results
2. Work difficulties in people with multiple sclerosis: the role of depression, anxiety and coping
- Author
-
van Egmond, E., van der Hiele, K., van Gorp, D., Jongen, S., van der Klink, J., Reneman, M., Beenakker, M., van Eijk, J., Frequin, S., de Gans, K., van Geel, B., Gerlach, O., Hengstman, G., Mostert, J., Verhagen, W., Middelkoop, H., Visser, L., and Extremities Pain and Disability (EXPAND)
- Published
- 2021
3. Personality traits are not associated with changes in employment status over 3 years in persons with multiple sclerosis.
- Author
-
van der Hiele, K., van Egmond, E. E. A., van Gorp, D. A. M., Jongen, P. J., Reneman, M. F., van der Klink, J. J. L., Beenakker, E. A. C., van Eijk, J. J. J., Frequin, S. T. F. M., Hoitsma, E., Gerlach, O. H. H., Mostert, J. P., Verhagen, W. I. M., Heerings, M. A. P., Middelkoop, H. A. M., and Visser, L. H.
- Abstract
Previous research discovered a protective effect of higher conscientiousness against a 3-year deterioration in employment status in persons with multiple sclerosis (pwMS). To replicate these findings, we used data from a multicentre prospective cohort study where 145 employed pwMS completed questionnaires, neurological and neuropsychological examinations at baseline and after 3 years. A 3-year deterioration in employment status was reported in 31.0%. We observed no differences in personality, demographics or clinical characteristics between pwMS with deteriorated or stable employment status. These null findings may be partly explained by the classification of deteriorated employment status, which does not reflect Dutch labour conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Relationship between personality traits and work functioning in people with multiple sclerosis
- Author
-
van Gorp, D. A. M., van der Hiele, K., van Egmond, E. E. A., Heerings, M. A. P., Jongen, P. J., van der Klink, J. J. L., Reneman, M. F., Arnoldus, E. P. J., Beenakker, E. A. C., Bos, H. M., van Eijk, J. J. J., Fermont, J., Frequin, S. T. F. M., de Gans, K., van Geel, B. M., Hengstman, G. J. D., Hoitsma, E., Hupperts, R. M. M., Moll, J. W. B., Mostert, J. P., Pop, P. H. M., Verhagen, W. I. M., Zemel, D., Middelkoop, H. A. M., Visser, L. H., and Extremities Pain and Disability (EXPAND)
- Published
- 2019
5. The MS@Work study after two years-factors related to (successful) work participation in patients with relapsing-remitting multiple sclerosis
- Author
-
van Gorp, D. A. M., van der Hiele, K., van Egmond, E. E. A., Heerings, M. A. P., Jongen, P. J., van der Klink, J. J. L., Reneman, M. F., Arnoldus, E. P. J., Beenakker, E. A. C., Bos, H. M., van Eijk, J. J. J., Fermont, J., Frequin, S. T. F. M., de Gans, K., van Geel, B. M., Hengstman, G. J. D., Hoitsma, E., Hupperts, R. M. M., Moll, J. W. B., Mostert, J. P., Pop, P. H. M., Verhagen, W. I. M., Zemel, D., Middelkoop, H. A. M., Visser, L. H., and Extremities Pain and Disability (EXPAND)
- Published
- 2019
6. A validation study of the Dutch Multiple Sclerosis Work Difficulties Questionnaire in relapsing-remitting multiple sclerosis
- Author
-
van Egmond, E. E. A., van Gorp, D. A. M., Honan, C. A., Heerings, M. A. P., Jongen, P. J., van der Klink, J. J. L., Reneman, M. F., Beenakker, E. A. C., Frequin, S. T. F. M., de Gans, K., Hengstman, G. J. D., Hoitsma, E., Mostert, J. P., Verhagen, W. I. M., Zemel, D., Middelkoop, H. A. M., Visser, L. H., van der Hiele, K., and Extremities Pain and Disability (EXPAND)
- Published
- 2019
7. Design of a Collection Digitisation Dashboard
- Author
-
van Egmond, E., Willemse, L., Paul, D., Woodburn, M., Casino, A., Gödderz, K., Vermeersch, X., Bloothoofd, J., Wijers, A., and Raes, N.
- Subjects
TDWG ,classification ,digitisation ,natural history collection ,dashboard ,DiSSCo ,ICEDIG ,collection description - Abstract
ICEDIG deliverable D2.3 reports on the outcomes of a number of workshops and the Task Group Collection Digitisation Dashboards (TG CDD) discussions and proposes preliminary schemes to describe natural history collections so that they can be summarized, visualized and consulted in a Collection Digitisation Dashboard. The report includes descriptions schemes based on taxonomy, stratigraphy, storage type, geographic regions and levels of digitisation. The schemes are piloted in two different dashboards, one for DiSSCo (Distributed System of Scientific Collections - dissco.eu) and one for the Dutch collection holding institutes.
- Published
- 2019
8. A minority of tumor associated antigen specific T cells restricted to self-HLA alleles is of sufficient avidity to recognize overexpressed endogenously processed antigen
- Author
-
Roex, M.C.J., Hageman, L., Egmond, E. van, Veld, S.A.J., Hoogstraten, C., Germeroth, L., Falkenburg, J.H.F., and Jedema, I.
- Published
- 2018
9. COMBINED ISOLATION OF MULTI ANTIGEN SPECIFIC T CELL PRODUCTS CONTAINING NAIVE AND/OR MEMORY VIRUS-SPECIFIC T CELLS AND T CELLS SPECIFIC FOR TUMOR ASSOCIATED AND MINOR HISTOCOMPATIBILITY ANTIGENS
- Author
-
Roex, M., Luna, J.M., Hageman, L., Egmond, E. van, Veld, S., Liempt, E. van, Hoogstraten, C., Germeroth, L., Balen, P. van, Halkes, S., Falkenburg, J.F., and Jedema, I.
- Published
- 2016
10. Combined isolation of virus specific T cells from seronegative donors, TAA and MiHA specific T cells for the prevention of viral infections and tumor relapses early after alloSCT
- Author
-
Roex, M., Luna, J.M., Hageman, L., Liempt, E. van, Egmond, E. van, Veld, S., Hoogstraten, C., Germeroth, L., Balen, P. van, Halkes, C., Falkenburg, F., and Jedema, I.
- Published
- 2016
11. Systematic review with meta‐analysis: neuroimaging in hepatitis C chronic infection.
- Author
-
Oriolo, G., Egmond, E., Mariño, Z., Cavero, M., Navines, R., Zamarrenho, L., Solà, R., Pujol, J., Bargallo, N., Forns, X., and Martin‐Santos, R.
- Subjects
- *
META-analysis , *HEPATITIS C , *BRAIN imaging , *HEPATIC encephalopathy , *NUCLEAR magnetic resonance spectroscopy - Abstract
Summary: Background: Chronic hepatitis C is considered a systemic disease because of extra‐hepatic manifestations. Neuroimaging has been employed in hepatitis C virus‐infected patients to find in vivo evidence of central nervous system alterations. Aims: Systematic review and meta‐analysis of neuroimaging research in chronic hepatitis C treatment naive patients, or patients previously treated without sustained viral response, to study structural and functional brain impact of hepatitis C. Methods: Using PRISMA guidelines a database search was conducted from inception up until 1 May 2017 for peer‐reviewed studies on structural or functional neuroimaging assessment of chronic hepatitis C patients without cirrhosis or encephalopathy, with control group. Meta‐analyses were performed when possible. Results: The final sample comprised 25 studies (magnetic resonance spectroscopy [N = 12], perfusion weighted imaging [N = 1], positron emission tomography [N = 3], single‐photon emission computed tomography [N = 4], functional connectivity in resting state [N = 1], diffusion tensor imaging [N = 2] and structural magnetic resonance imaging [N = 2]). The whole sample was of 509 chronic hepatitis C patients, with an average age of 41.5 years old and mild liver disease. A meta‐analysis of magnetic resonance spectroscopy studies showed increased levels of choline/creatine ratio (mean difference [MD] 0.12, 95% confidence interval [CI] 0.06‐0.18), creatine (MD 0.85, 95% CI 0.42‐1.27) and glutamate plus glutamine (MD 1.67, 95% CI 0.39‐2.96) in basal ganglia and increased levels of choline/creatine ratio in centrum semiovale white matter (MD 0.13, 95% CI 0.07‐0.19) in chronic hepatitis C patients compared with healthy controls. Photon emission tomography studies meta‐analyses did not find significant differences in PK11195 binding potential in cortical and subcortical regions of chronic hepatitis C patients compared with controls. Correlations were observed between various neuroimaging alterations and neurocognitive impairment, fatigue and depressive symptoms in some studies. Conclusions: Patients with chronic hepatitis C exhibit cerebral metabolite alterations and structural or functional neuroimaging abnormalities, which sustain the hypothesis of hepatitis C virus involvement in brain disturbances. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
12. Tropical sprue and intussusception: An unusual association: Report of a case
- Author
-
Cortell, Stanley, Rieber, Egmond E., Sheehy, Thomas W., and Conrad, Marcel E.
- Published
- 1967
- Full Text
- View/download PDF
13. Low incidence of viral complications after in vivo and in vitro T-cell depletion using low dose alemtuzumab is due to early post transplant outgrowth of protective virus specific CD4 and CD8 memory T-cells by various escape mechanisms
- Author
-
Halkes, C., Falkenburg, J.H.F., Egmond, E. van, Meent, M. van, Borne, P. von dem, Marijt, W.A.F., Veelken, J.H., and Jedema, I.
- Published
- 2012
14. Rabbit-derived ATG but not horse-derived ATG in the conditioning induces a post transplant in vivo imbalance between B and T cell recovery resulting in high risk of EBV-associated PTLD
- Author
-
Halkes, C., Falkenburg, J., Egmond, E. van, Wolbers, J.O., Starrenburg, I., Borne, P. von dem, Marijt, W.A.F., Veelken, J.H., and Jedema, I.
- Published
- 2012
15. Dutch Nao Team: team description for RoboCup 2011 - Istanbul
- Author
-
Visser, A., ten Velthuis, D., Wiggers, A., Verschoor, C., Cabot, M., van Egmond, E., Keune, A., Fodor, E., van Zanten, J., Nugteren, S., van der Molen, H., van Bellen, M., Koster, E., Laan, S., Bodewes, B., Dingeman, T., Gieske, S., de Groot, M., Iepsma, R., Jozefzoon, O., Moerbeek, R., van Rossum, T., Rozenboom, R., van Noort, S., and Amsterdam Machine Learning lab (IVI, FNWI)
- Published
- 2011
16. European overview of sustainable policies and approaches in COST C25 member countries
- Author
-
Gervásio, Helena Maria Santos, Blok, Rijk, Silva, L. Simões da, Giarma, C., Bikas, D., Grecea, D., Van Egmond, E., Krigsvoll, G., Koukkari, Heli, Kahraman, I., Kontoleon, K., Bragança, L., Broniewicz, M., Fumo, M., Glaumann, M., Wallhagen, M., Huovila, P., Mateus, Ricardo, Morbiducci, R., Ungureanu, Vionel, and Universidade do Minho
- Subjects
Sustainability ,Building ,Construction - Abstract
The implementation of the principles and methods towards a Sustainable Construction varies across different countries in Europe. In some countries, the sustainability of the construction sector has been effectively taken into consideration over the last years, while in other its implementation is at an initial stage. Many reasons may be pointed out for this situation. Different countries have different understandings of what is entailed in Sustainable Construction. Different cultural and educational backgrounds, along with different priorities in each country, are also contributing for the lack of a common European approach. General frameworks, aiming to cover every aspect of Sustainable Construction and to provide a consistent and integrated approach, such as Agenda 21 for Sustainable Construction, gave a major advance in the search for a common approach for the construction sector. However, general agreed methodologies and tools to make this common approach operational are still missing., European Science Foundation - COST Action C25
- Published
- 2011
17. Dutch Nao team - technical report 2011
- Author
-
Verschoor, C., Wiggers, A., ten Velthuis, D., Keune, A., Cabot, M., Nugteren, S., van Egmond, E., van der Molen, H., Iepsma, R., van Bellen, M., de Groot, M., Fodor, E., Rozeboom, R., Visser, A., and Amsterdam Machine Learning lab (IVI, FNWI)
- Published
- 2011
18. New antiviral treatments for chronic hepatitis C and health-related quality of life: A systematic review and meta-analysis
- Author
-
Egmond, E., Navinés, R., Oriolo, G., Mariño, Z., Pla, A., Bartres, C., Cavero, M., Subirá, S., Forns, X., and Martin-Santos, R.
- Published
- 2017
- Full Text
- View/download PDF
19. Substance abuse and quality of life in chronic hepatitis C patients receiving antiviral treatment
- Author
-
Egmond, E., Oriolo, G., Cavero, M., Langohr, K., Solà, R., Navines, R., and Martin-Santos, R.
- Published
- 2016
- Full Text
- View/download PDF
20. Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression.
- Author
-
Udina, M., Navinés, R., Egmond, E., Oriolo, G., Langohr, K., Gimenez, D., Valdés, M., Gómez-Gil, E., Grande, I., Gratacós, M., Kapczinski, F., Artigas, F., Vieta, E., Solà, R., and Martín-Santos, R.
- Subjects
NEUROTROPHIC functions ,NEUROTROPHINS ,GLUCOCORTICOID receptors ,SEROTONIN ,DOPAMINE ,NEURAL transmission - Abstract
Background: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, proinflammatory cytokines change brain function in several ways, such as altering neurotransmitters, the glucocorticoid axis, and apoptotic mechanisms. This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with chronic hepatitis C. We investigated clinical, personality, and functional genetic variants associated with cytokine-induced depression. Methods: We recruited 344 Caucasian outpatients with chronic hepatitis C, initiating IFN-alpha and ribavirin therapy. All patients were euthymic at baseline according to DSM-IV-R criteria. Patients were assessed at baseline and 4, 12, 24, and 48 weeks after treatment initiation using the Patient Health Questionnaire (PHQ), the Hospital Anxiety and Depression Scale (HADS), and the Temperament and Character Inventory (TCI). We genotyped several functional polymorphisms of interleukin-28 (IL28B), indoleamine 2,3-dioxygenase (IDO-1), serotonin receptor-1A (HTR1A), catechol-O-methyl transferase (COMT), glucocorticoid receptors (GCR1 and GCR2), brain-derived neurotrophic factor (BDNF), and FK506 binding protein 5 (FKBP5) genes. A survival analysis was performed, and the Cox proportional hazards model was used for the multivariate analysis. Results: The cumulative incidence of depression was 0.35 at week 24 and 0.46 at week 48. The genotypic distributions were in Hardy-Weinberg equilibrium. Older age (p = 0.018, hazard ratio [HR] per 5 years = 1.21), presence of depression history (p = 0.0001, HR = 2.38), and subthreshold depressive symptoms at baseline (p = 0.005, HR = 1.13) increased the risk of IFNinduced depression. So too did TCI personality traits, with high scores on fatigability (p = 0.0037, HR = 1.17), impulsiveness (p = 0.0200 HR = 1.14), disorderliness (p = 0.0339, HR = 1.11), and low scores on extravagance (p = 0.0040, HR = 0.85). An interaction between HTR1A and COMT genes was found. Patients carrying the G allele of HTR1A plus the Met substitution of the COMT polymorphism had a greater risk for depression during antiviral treatment (HR = 3.83) than patients with the CC (HTR1A) and Met allele (COMT) genotypes. Patients carrying the HTR1A CC genotype and the COMT Val/Val genotype (HR = 3.25) had a higher risk of depression than patients with the G allele (HTR1A) and the Val/Val genotype. Moreover, functional variants of the GCR1 (GG genotype: p = 0.0436, HR = 1.88) and BDNF genes (Val/Val genotype: p = 0.0453, HR = 0.55) were associated with depression. Conclusions: The results of the study support the theory that IFN-induced depression is associated with a complex pathophysiological background, including serotonergic and dopaminergic neurotransmission as well as glucocorticoid and neurotrophic factors. These findings may help to improve the management of patients on antiviral treatment and broaden our understanding of the pathogenesis of mood disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
21. Health-related Quality of Life, Psychiatric History, and HIV Comorbidity in Hepatitis C Patients Receiving Antiviral Treatment: a Systematic Review
- Author
-
Egmond, E., Navinés, R., Cavero, M., Alvarez, M., Subirà, S., Forns, X., and Martin-Santos, R.
- Published
- 2015
- Full Text
- View/download PDF
22. Daylighting Performance of Glass Dominance Office Building Facade In Indonesia.
- Author
-
Dinapradipta, A., Post, J. M., Egmond, E. V., and Mohammadi, M.
- Subjects
OFFICE buildings ,DAYLIGHTING ,DAYLIGHT ,LIGHTING - Abstract
Most of modern high rise office buildings in tropical humid region are experiencing new trend in their physical facade design. They have large glazing area in order to make the image of modern an corollary the need for a light construction. The objective of this study was to assess the daylighting performance, i.e. daylight intensity level and their uniformity in the open plan glass-facade offices due to the building's glass type and its core position which affects the window arrangement. Three case studies were conducted at typical Indonesian office buildings with different core positions which determine the possible availability of daylighting sources, the type of glazing and the interior shading they are used. Overall the findings show that the bilateral side daylighting system contributes to more even and gentle distribution compared to that of multilateral side light window. Furthermore, the application of both tinted and refrective type of glazing contribute to significantly high illuminance level in the building perimeter and considerably low illuminance level in the core zone. Hence, this also affects the daylight uniformity performance in the space. Among building physical variables studied, buildings with reflective glass facade and that with single side core (multilateral window positions) provide more contribution to these phenomenon compared to those with tinted glazing and other two window positions. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
23. Restriction fragment length polymorphisms, races and vegetative compatibility groups within a worldwide collection of <em>Fusarium oxysporum</em> f.sp. <em>gladioli</em>.
- Author
-
Mes, J. J., Van Doorn, J., Roebroeck, E. J. A., Van Egmond, E., Van Aartrijk, J., and Boonekamp, P. M.
- Subjects
FUSARIUM oxysporum ,GENETIC polymorphisms ,BIOCOMPATIBILITY ,DNA ,PATHOGENIC microorganisms ,GENETICS - Abstract
Isolates of Fusarium oxysporum f.sp. gladioli were collected from widely different geographic areas. These isolates were characterized by pathogenicity to two differential gladiolus cultivars, vegetative compatibility, and total genomic DNA restriction fragment length polymorphisms (RFLPs). RFLPs were used to estimate the genetic divergence and relationship among isolates of F. oxysporum. RFLPs were detected by Southern blot hybridization of total genomic DNA with a 3 4 kb DNA probe generated from total DNA of F. oxysporum f.sp. dianthi. Cluster analysis allowed the division of pathogenic strains into three main RFLP groups, each group containing strains with similarity coefficients ranging from 78 to 100%. RFLP groups correlated with vegetative compatibility groups, not with races. Two single pathogenic isolates which could not be assigned to any of the three main vegetative compatibility groups also had distinctive RFLP patterns. Little genetic polymorphism was observed within vegetative compatibility groups, whereas the majority of RFLPs occurred between vegetative compatibility groups, suggesting a common ancestry for strains within a specific vegetative compatibility group and a polyphyletic origin for the present special form gladioli. [ABSTRACT FROM AUTHOR]
- Published
- 1994
- Full Text
- View/download PDF
24. Dietary intakes of some essential and non‐essential trace elements, nitrate, nitrite and N ‐nitrosamines, by Dutch adults: Estimated via a 24‐hour duplicate portion study.
- Author
-
Ellen, G., Egmond, E., Van Loon, J. W., Sahertian, E. T., and Tolsma, K.
- Published
- 1990
- Full Text
- View/download PDF
25. Gastrectomy and Iron Absorption.
- Author
-
Rieber, Egmond E., Conrad, Marcel E., and Crosby, William H.
- Published
- 1967
- Full Text
- View/download PDF
26. Red Cells in Sickle Cell Crisis: Observations on the Pathophysiology of Crisis
- Author
-
Rieber, Egmond E., Veliz, Gaston, and Pollack, Simeon
- Published
- 1977
- Full Text
- View/download PDF
27. Reduction of Oxidized Glutathione in Normal and Glucose-6-Phosphate Dehydrogenase Deficient Erythrocytes and Their Hemolysates
- Author
-
Rieber, Egmond E. and Jaffé, Ernst R.
- Published
- 1970
- Full Text
- View/download PDF
28. Mass Spectrometric Quantification of Traces of Volatile N-Nitrosamines in Meat Products
- Author
-
Freudenthal, J., Egmond, E., Gramberg, L. G., Stephany, R. W., and Schuller, P. L.
- Published
- 1976
- Full Text
- View/download PDF
29. Coronary vessel alterations following chronic carbon monoxide exposure in the adult rat
- Author
-
Penney, D. G., Giraldo, A. A., and Van Egmond, E. M.
- Subjects
RATS ,CARBON monoxide - Published
- 1994
- Full Text
- View/download PDF
30. Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis.
- Author
-
van Egmond EEA, van der Hiele K, de Rooij MJ, van Gorp DAM, Jongen PJ, van der Klink JJL, Reneman MF, Beenakker EAC, van Eijk JJJ, Frequin STFM, de Gans K, Hoitsma E, Gerlach OHH, Mostert JP, Verhagen WIM, Visser LH, and Middelkoop HAM
- Abstract
Purpose: To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS)., Methods: 170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status., Results: People with a deteriorated employment status after three years reported more depression ( p= 0.009), a higher impact of fatigue ( p< 0.001), more cognitive complaints ( p< 0.001) and less workplace support ( p= 0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status., Conclusion: More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status., Competing Interests: E.E.A. van Egmond, K. van der Hiele, M.J. de Rooij, D.A.M. van Gorp, J.J.L. van der Klink, M.F. Reneman, E.A.C. Beenakker, S.T.F.M. Frequin, K. de Gans, O.H.H. Gerlach, J.P. Mostert, and H.A.M. Middelkoop declare no conflict of interestP.J. Jongen received honoraria from Bayer Netherlands and Orikami Personalized Health Care for consultancy activities and is chairman of the MSmonitor Foundation.L.H. Visser received a research grant for the multicentre BIA study from Merck, received consultancy fees from Merck, Novartis and JanssenJ.J.J. van Eijk received consultancy fees and honoraria for lectures from Merck, Biogen, Novartis, Sanofi, Janssen and RocheE. Hoitsma received honoraria for lectures and advisory boards from Bayer, Biogen, Roche, Sanofi Genzyme, Merck Serono, Novartis and Teva.W.I.M. Verhagen received consultancy fees from Merck and Biogen, (© 2024 The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
31. A mixed-method approach to determining contact matrices in the Cox's Bazar refugee settlement.
- Author
-
Walker J, Aylett-Bullock J, Shi D, Kahindo Maina AG, Samir Evers E, Harlass S, and Krauss F
- Abstract
Contact matrices are an important ingredient in age-structured epidemic models to inform the simulated spread of the disease between subgroups of the population. These matrices are generally derived using resource-intensive diary-based surveys and few exist in the Global South or tailored to vulnerable populations. In particular, no contact matrices exist for refugee settlements-locations under-served by epidemic models in general. In this paper, we present a novel, mixed-method approach for deriving contact matrices in populations, which combines a lightweight, rapidly deployable survey with an agent-based model of the population informed by census and behavioural data. We use this method to derive the first set of contact matrices for the Cox's Bazar refugee settlement in Bangladesh. To validate our approach, we apply it to the UK population and compare our derived matrices with well-known contact matrices collected using traditional methods. Our findings demonstrate that our mixed-method approach successfully addresses some of the challenges faced by traditional and agent-based approaches to deriving contact matrices. It also shows potential for implementation in resource-constrained environments. This work therefore contributes to a broader aim of developing new methods and mechanisms of data collection for modelling disease spread in refugee and internally displaced person (IDP) settlements and better serving these vulnerable communities., Competing Interests: We declare we have no competing interests., (© 2023 The Authors.)
- Published
- 2023
- Full Text
- View/download PDF
32. Cerebrospinal fluid fistula as a complication of reverse transcriptase-polymerase chain reaction collection for the detection of coronavirus disease 2019: illustrative cases.
- Author
-
Palavani LB, Andrade CVF, Andrade RA, Alves E, Barros MF, and Barbieri JF
- Abstract
Background: The most used method to detect coronavirus disease 2019 during the pandemic is reverse transcriptase-polymerase chain reaction with nasal swab. Despite being highly effective, the test does not leave the patient risk-free and can lead to serious complications. These can be traumatic nasal cerebrospinal fluid (CSF) fistula and its consequences, such as meningitis., Observations: In this article, the authors present 4 case reports and a literature review. The following MeSH terms in the research were used: "CSF leak case report and covid 19." Six results were found and after searching the references and keywords 16 articles were identified. By using them, the authors tried to clarify the etiology of the fistula, its influences, and complications., Lessons: The authors conclude that professionals must receive training, since CSF fistula originates from technical failure and lack of anatomical knowledge. The diagnosis cannot be neglected because it can bring complications to the patient's health.
- Published
- 2023
- Full Text
- View/download PDF
33. Subjective cognitive impairment is related to work status in people with multiple sclerosis.
- Author
-
van Wegen J, van Egmond EEA, Benedict RHB, Beenakker EAC, van Eijk JJJ, Frequin STFM, de Gans K, Gerlach OHH, van Gorp DAM, Hengstman GJD, Jongen PJ, van der Klink JJL, Reneman MF, Verhagen WIM, Middelkoop HAM, Visser LH, Hulst HE, and van der Hiele K
- Abstract
Background: Unemployment is common among people with multiple sclerosis (pwMS) and has been associated with subjective cognitive difficulties, specifically in memory, attention, and executive functioning. However, longitudinal research on subjective cognitive difficulties and employment is scarce., Objective: We investigated whether subjective cognitive impairment (SCI), based on the clinical cut-off score of the MS Neuropsychological Screening Questionnaire (MSNQ), was associated with work status and negative work events (NWE) at baseline and after 2 years. Moreover, we investigated whether four MSNQ subdomains were related to work status and NWE., Methods: 287 participants (77.4% female, median age = 42 years) completed questionnaires on subjective cognitive functioning, depression, anxiety, and fatigue, and completed the Symbol Digit Modalities Test (SDMT). After baseline comparisons, logistic regression analyses were performed, with work status and NWE at baseline, and employment change and NWE change within 2 years after baseline as dependent variables. Independent variables included SCI and the MSNQ domains. Covariates anxiety, depression, fatigue, and SDMT were added., Results: SCI, depression and anxiety were associated with work status ( Nagelkerke R
2 = .286), but only SCI was associated with employment change ( Nagelkerke R2 = .164). No predictors were associated with NWE at baseline or follow-up. In addition, no MSNQ subdomain was related to work status, employment change or NWE., Conclusion: Unemployed pwMS and pwMS with a deteriorated work status reported more cognitive difficulties after 2 years than employed pwMS or pwMS with a stable work status. In addition, depression, and anxiety were associated with work status., Competing Interests: The authors declare no conflict of interest., (© 2022 The Authors.)- Published
- 2022
- Full Text
- View/download PDF
34. Work difficulties in people with multiple sclerosis: The role of anxiety, depression and coping.
- Author
-
van Egmond E, van der Hiele K, van Gorp D, Jongen PJ, van der Klink J, Reneman MF, Beenakker E, van Eijk J, Frequin S, de Gans K, van Geel BM, Gerlach O, Hengstman G, Mostert JP, Verhagen W, Middelkoop H, and Visser LH
- Abstract
Background: Symptoms of anxiety and depression affect the daily life of people with multiple sclerosis (MS). This study examined work difficulties and their relationship with anxiety, depression and coping style in people with MS., Methods: 219 employed people with MS (median age = 43 years, 79% female) completed questionnaires on anxiety, depression, coping style, demographics and work difficulties, and underwent a neurological examination. Two regression analyses were performed with work difficulties as the dependent variable and either anxiety or depression as continuous independent variables. Coping style, age, gender, educational level, MS-related disability and disease duration were added as additional predictors, as well as interaction terms between coping style and either symptoms of depression or anxiety., Results: A significant model was found ( F
(10,205) = 13.14, p < 0.001, R2 = 0.39) in which anxiety, emotion- and avoidance-oriented coping and MS-related disability were positively related to work difficulties. The analysis of depression resulted in a significant model ( F(10,205) = 14.98, p < 0.001, R2 = 0.42) in which depression, emotion- and avoidance-oriented coping and MS-related disability were positively related to work difficulties. None of the interaction effects were significant., Conclusions: Work difficulties were positively related to anxiety, depression, emotion- and avoidance-oriented coping and MS-related disability in workers with MS., Competing Interests: Declaration of conflicting interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Disclosure: E. van Egmond, K. van der Hiele, D. van Gorp, J. van der Klink, M. Reneman, E. Beenakker, K. de Gans, B.M. van Geel, O. Gerlach, J. Mostert, and H. Middelkoop report no conflict of interest. P. Jongen received honoraria from Bayer Netherlands and Orikami Personalized Health Care, Netherlands, for consultancy activities and is chairman of the MSmonitor foundation, Netherlands. J. van Eijk received honoraria for lectures and honoraria for advisory boards from Sanofi Genzyme, Roche, Merck Serono, Novartis and Teva. S. Frequin received honoraria for lectures, grants for research and honoraria for advisory boards from Sanofi Genzyme, Merck Serono, Novartis, Biogen and Roche. G. Hengstman has received consultation fees and grants from Biogen, BMS, Genzyme-Sanofi, Merck BV, Novartis Pharma and Roche. W. Verhagen received honoraria for lectures from Biogen and Merck Serono, reimbursement for hospitality from Biogen, Sanofi Genzyme and Merck Serono, and honoraria for advisory boards from Merck Serono. L.H. Visser received honoraria for lectures and honoraria for advisory boards from Merck Serono and Novartis., (© The Author(s), 2022.)- Published
- 2022
- Full Text
- View/download PDF
35. Operational response simulation tool for epidemics within refugee and IDP settlements: A scenario-based case study of the Cox's Bazar settlement.
- Author
-
Aylett-Bullock J, Cuesta-Lazaro C, Quera-Bofarull A, Katta A, Hoffmann Pham K, Hoover B, Strobelt H, Moreno Jimenez R, Sedgewick A, Samir Evers E, Kennedy D, Harlass S, Gidraf Kahindo Maina A, Hussien A, and Luengo-Oroz M
- Subjects
- Bangladesh epidemiology, COVID-19 prevention & control, Comorbidity, Computational Biology, Computer Simulation, Data Visualization, Disease Progression, Humans, Masks, Physical Distancing, Schools, Systems Analysis, COVID-19 epidemiology, COVID-19 transmission, Epidemics, Refugees statistics & numerical data, SARS-CoV-2
- Abstract
The spread of infectious diseases such as COVID-19 presents many challenges to healthcare systems and infrastructures across the world, exacerbating inequalities and leaving the world's most vulnerable populations most affected. Given their density and available infrastructure, refugee and internally displaced person (IDP) settlements can be particularly susceptible to disease spread. In this paper we present an agent-based modeling approach to simulating the spread of disease in refugee and IDP settlements under various non-pharmaceutical intervention strategies. The model, based on the June open-source framework, is informed by data on geography, demographics, comorbidities, physical infrastructure and other parameters obtained from real-world observations and previous literature. The development and testing of this approach focuses on the Cox's Bazar refugee settlement in Bangladesh, although our model is designed to be generalizable to other informal settings. Our findings suggest the encouraging self-isolation at home of mild to severe symptomatic patients, as opposed to the isolation of all positive cases in purpose-built isolation and treatment centers, does not increase the risk of secondary infection meaning the centers can be used to provide hospital support to the most intense cases of COVID-19. Secondly we find that mask wearing in all indoor communal areas can be effective at dampening viral spread, even with low mask efficacy and compliance rates. Finally, we model the effects of reopening learning centers in the settlement under various mitigation strategies. For example, a combination of mask wearing in the classroom, halving attendance regularity to enable physical distancing, and better ventilation can almost completely mitigate the increased risk of infection which keeping the learning centers open may cause. These modeling efforts are being incorporated into decision making processes to inform future planning, and further exercises should be carried out in similar geographies to help protect those most vulnerable., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
- Full Text
- View/download PDF
36. Self-reported occupational functioning in persons with relapsing-remitting multiple sclerosis: Does personality matter?
- Author
-
van der Hiele K, van Gorp DAM, van Egmond EEA, Jongen PJ, Reneman MF, van der Klink JJL, Arnoldus EPJ, Beenakker EAC, van Eijk JJJ, Frequin STFM, de Gans K, Hengstman GJD, Hoitsma E, Gerlach OHH, Verhagen WIM, Heerings MAP, Middelkoop HAM, and Visser LH
- Subjects
- Adult, Depression epidemiology, Depression etiology, Fatigue epidemiology, Fatigue etiology, Female, Humans, Male, Middle Aged, Personality, Self Report, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting epidemiology
- Abstract
Background: Multiple sclerosis (MS) poses a major threat to sustainable employability. Identifying conditions and factors that promote work participation is of great importance. Our objective was to explore the contribution of personality traits in explaining occupational functioning in MS., Methods: 241 participants with relapsing-remitting MS (78% female, median age: 42.0 years, median EDSS: 2.0) and 60 healthy controls (70% female, median age: 45.0 years) underwent neuropsychological and neurological examinations and completed questionnaires. Multivariate logistic and linear regression analyses were conducted to examine relations between personality traits and self-reported occupational functioning, while accounting for known correlates., Results: Personality traits were not associated with self-reported occupational functioning when correcting for known correlates. A higher impact of fatigue (B = -0.05, p = .005 and B = -0.04, p = .009) and depression (B = -0.22, p = .008 and B = -0.21, p = .01) were associated with no paid job (R
2 = 0.13) and considering to reduce work hours (R2 = 0.12). A higher impact of fatigue (B = -0.05, p = .008, β = 0.46, p = .001 and β = -0.36, p = .001) was associated with absenteeism from work (R2 = 0.15), more presenteeism (R2 = 0.35) and lower work ability (R2 = 0.25). A higher impact of fatigue (β = 0.46, p = .001) and anxiety (β = 0.25, p = .001) were associated with more work difficulties (R2 = 0.54)., Conclusion: Personality traits did not explain additional variance in self-reported occupational functioning in persons with relapsing-remitting MS with mild disability. The impact of fatigue was the main and most consistent correlate of occupational functioning, often combined with depression or anxiety. Total explained variance of the models was limited, emphasizing the need to additionally examine other (contextual) factors when considering occupational challenges in MS., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
37. A Dutch validation study of the Multiple Sclerosis Work Difficulties Questionnaire in relapsing remitting multiple sclerosis.
- Author
-
van Egmond E, van Gorp D, Honan C, Heerings M, Jongen P, van der Klink J, Reneman M, Beenakker E, Frequin S, de Gans K, Hengstman G, Hoitsma E, Mostert J, Verhagen W, Zemel D, Middelkoop H, Visser L, and van der Hiele K
- Subjects
- Employment, Humans, Quality of Life, Reproducibility of Results, Surveys and Questionnaires, Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
- Abstract
Purpose: The current study aimed to evaluate the psychometric properties of the Dutch version of the Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23)., Methods: Two hundred and thirty-nine employed persons with multiple sclerosis (MS) and 59 healthy controls completed the MSWDQ-23. To verify the factor structure, a confirmatory factor analysis was conducted. To assess construct validity, the MSWDQ-23 scores were correlated to measures of physical disability, fatigue, cognitive and neuropsychiatric problems, depression, health-related quality of life, and work-related variables. MSWDQ-23 scores were compared within different age groups, gender, education levels, and job types. Predictive validity was assessed using a logistic regression analysis to predict a deterioration in employment status after one year based on MSWDQ-23 scores., Results: The internal consistency of the MSWDQ-23 was acceptable ( α = 0.913, 95% CI = 0.897-0.928) and the results indicated a fair fit. The MSWDQ-23 showed acceptable construct validity, confirming 94% of the hypotheses. The total scale and the psychological/cognitive subscale were able to predict a deterioration in employment status after one year ( χ
2 (1)=18.164, p < 0.001)., Conclusions: The Dutch version of the MSWDQ-23 is a valid and internally consistent instrument to measure self-reported work difficulties in persons with MS.Implications for rehabilitationThe Dutch version of the 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) is a reliable and valid tool to measure self-reported work difficulties in people with multiple sclerosis (MS).More psychological and cognitive work difficulties are predictive of a deteriorated employment status after one year.The MSWDQ-23 is a helpful tool for researchers and (occupational) health professionals to identify current work difficulties in persons with MS and identify persons at risk for a deterioration in employment one year later.- Published
- 2021
- Full Text
- View/download PDF
38. Effect of alemtuzumab-based T-cell depletion on graft compositional change in vitro and immune reconstitution early after allogeneic stem cell transplantation.
- Author
-
Roex MCJ, Wijnands C, Veld SAJ, van Egmond E, Bogers L, Zwaginga JJ, Netelenbos T, von dem Borne PA, Veelken H, Halkes CJM, Falkenburg JHF, and Jedema I
- Subjects
- Adult, Antineoplastic Agents, Immunological pharmacology, Graft vs Host Disease immunology, Humans, Male, Middle Aged, Prospective Studies, T-Lymphocyte Subsets physiology, Alemtuzumab pharmacology, Hematopoietic Stem Cell Transplantation, Immune Reconstitution, Lymphocyte Depletion methods, T-Lymphocyte Subsets drug effects
- Abstract
Background Aims: To reduce the risk of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloSCT), T-cell depletion (TCD) of grafts can be performed by the addition of alemtuzumab (ALT) "to the bag" (in vitro) before transplantation. In this prospective study, the authors analyzed the effect of in vitro incubation with 20 mg ALT on the composition of grafts prior to graft infusion. Furthermore, the authors assessed whether graft composition at the moment of infusion was predictive for T-cell reconstitution and development of GVHD early after TCD alloSCT., Methods: Sixty granulocyte colony-stimulating factor-mobilized stem cell grafts were obtained from ≥9/10 HLA-matched related and unrelated donors. The composition of the grafts was analyzed by flow cytometry before and after in vitro incubation with ALT. T-cell reconstitution and incidence of severe GVHD were monitored until 12 weeks after transplantation., Results: In vitro incubation of grafts with 20 mg ALT resulted in an initial median depletion efficiency of T-cell receptor (TCR) α/β T cells of 96.7% (range, 63.5-99.8%), followed by subsequent depletion in vivo. Graft volumes and absolute leukocyte counts of grafts before the addition of ALT were not predictive for the efficiency of TCR α/β T-cell depletion. CD4
pos T cells were depleted more efficiently than CD8pos T cells, and naive and regulatory T cells were depleted more efficiently than memory and effector T cells. This differential depletion of T-cell subsets was in line with their reported differential CD52 expression. In vitro depletion efficiencies and absolute numbers of (naive) TCR α/β T cells in the grafts after ALT incubation were not predictive for T-cell reconstitution or development of GVHD post- alloSCT., Conclusions: The addition of ALT to the bag is an easy, fast and generally applicable strategy to prevent GVHD in patients receiving alloSCT after myeloablative or non-myeloablative conditioning because of the efficient differential depletion of donor-derived lymphocytes and T cells., (Copyright © 2020 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
39. A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity.
- Author
-
Roex MCJ, Hageman L, Veld SAJ, van Egmond E, Hoogstraten C, Stemberger C, Germeroth L, Einsele H, Falkenburg JHF, and Jedema I
- Subjects
- Humans, Interferon-gamma immunology, Peptides immunology, Antigen Presentation, Antigens, Neoplasm immunology, Cancer Vaccines immunology, HLA-A2 Antigen immunology, Minor Histocompatibility Antigens immunology, T-Lymphocytes, Cytotoxic immunology
- Abstract
Tumor-associated antigens (TAAs) are monomorphic self-antigens that are proposed as targets for immunotherapeutic approaches to treat malignancies. We investigated whether T cells with sufficient avidity to recognize naturally overexpressed self-antigens in the context of self-HLA can be found in the T-cell repertoire of healthy donors. Minor histocompatibility antigen (MiHA)-specific T cells were used as a model, as the influence of thymic selection on the T-cell repertoire directed against MiHA can be studied in both self (MiHApos donors) and non-self (MiHAneg donors) backgrounds. T-cell clones directed against the HLA*02:01-restricted MiHA HA-1H were isolated from HA-1Hneg/HLA-A*02:01pos and HA-1Hpos/HLA-A*02:01pos donors. Of the 16 unique HA-1H-specific T-cell clones, five T-cell clones derived from HA-1Hneg/HLA-A*02:01pos donors and one T-cell clone derived from an HA-1Hpos/HLA-A*02:01pos donor showed reactivity against HA-1Hpos target cells. In addition, in total, 663 T-cell clones (containing at least 91 unique clones expressing different T-cell receptors) directed against HLA*02:01-restricted peptides of TAA WT1-RMF, RHAMM-ILS, proteinase-3-VLQ, PRAME-VLD, and NY-eso-1-SLL were isolated from HLA-A*02:01pos donors. Only 3 PRAME-VLD-specific and one NY-eso-1-SLL-specific T-cell clone provoked interferon-γ production and/or cytolysis upon stimulation with HLA-A*02:01pos malignant cell lines (but not primary malignant samples) naturally overexpressing the TAA. These results show that self-HLA-restricted T cells specific for self-antigens such as MiHA in MiHApos donors and TAAs are present in peripheral blood of healthy individuals. However, clinical efficacy would require highly effective in vivo priming by peptide vaccination in the presence of proper adjuvants or in vitro expansion of the low numbers of self-antigen-specific T cells of sufficient avidity to recognize endogenously processed antigen., (© 2020 by The American Society of Hematology.)
- Published
- 2020
- Full Text
- View/download PDF
40. Empathy in multiple sclerosis--Correlates with cognitive, psychological and occupational functioning.
- Author
-
van der Hiele K, van Egmond EEA, Jongen PJ, van der Klink JJL, Beenakker EAC, van Eijk JJJ, Frequin STFM, Hoitsma E, Mostert JP, Verhagen WIM, van Gorp DAM, Middelkoop HAM, and Visser LH
- Subjects
- Adult, Cognitive Dysfunction etiology, Depression etiology, Educational Status, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting complications, Neuropsychological Tests, Cognitive Dysfunction physiopathology, Depression physiopathology, Efficiency physiology, Empathy physiology, Employment psychology, Multiple Sclerosis, Relapsing-Remitting physiopathology, Multiple Sclerosis, Relapsing-Remitting psychology, Personality physiology, Social Cognition
- Abstract
Background: Recent studies report deficits in social cognition in individuals with multiple sclerosis (MS). Social cognitive skills such as empathy are important for adequate social and occupational functioning. Our objectives are: (1) to examine whether empathy differs between individuals with MS and healthy controls, (2) to examine relations between empathy and cognitive, psychological and occupational functioning., Methods: 278 individuals with MS (relapsing-remitting subtype) and 128 healthy controls from the MS@Work study participated in this investigation. The participants completed questionnaires about demographics, cognitive, psychological and occupational functioning, and underwent neurological and neuropsychological examinations. Mann-Whitney U-tests were used to examine group differences in empathy. Pearson and Spearman rank correlation analyses were used to examine relations between empathy and the other measures., Results: Empathy did not differ between individuals with MS and healthy controls. In individuals with MS, higher empathy was correlated with a higher educational level (X
2 (df) = 13.2(2), p = 0.001), better verbal learning (r = 0.20, p = 0.001), less symptoms of depression (r=-0.21, p = 0.001), higher extraversion (r = 0.25, p ≤ 0.001), agreeableness (r = 0.55, p ≤ 0.001) and conscientiousness (r = 0.27, p ≤ 0.001) and better occupational functioning in terms of work scheduling and output demands (r = 0.23, p = 0.002) and less cognitive/psychological work barriers (r = -0.21, p = 0.001). In healthy controls, higher empathy was correlated with less symptoms of depression (r = -0.34, p ≤ 0.001), less fatigue (r = -0.37, p ≤ 0.001), higher agreeableness (r = 0.59, p ≤ 0.001) and better occupational functioning in terms of work ability as compared to lifetime best (r = 0.28, p = 0.001) and less cognitive/psychological work barriers (r = -0.34, p ≤ 0.001). Empathy did not differ between unemployed and employed individuals with MS or healthy controls., Conclusion: Empathy did not differ between individuals with MS and healthy controls. Within both investigated groups, higher empathy was weakly to moderately correlated with less symptoms of depression, higher agreeableness and better occupational functioning. We also found unique correlations for empathy within the investigated groups. Longitudinal studies are needed to further examine social cognition in relation to cognitive, psychological and occupational functioning in both individuals with MS and healthy controls. It would be particularly interesting to concurrently examine changes in the brain network involved with social cognition., Competing Interests: Declaration of Competing Interest All authors declare no conflicts of interest., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
41. Building operational readiness for responding to emergencies in the WHO South-East Asia Region.
- Author
-
Pesigan A, Bhola AK, Pak HC, Perera S, Prawira J, von Harbou K, Sinha SK, Buddha N, Curtin Niemi T, Evers E, and Ofrin RH
- Subjects
- Asia, Southeastern, Humans, World Health Organization, Capacity Building organization & administration, Disaster Planning organization & administration, Emergencies, Public Health
- Abstract
The World Health Organization (WHO) has an essential role to play in supporting Member States to prepare for, respond to and recover from emergencies with public health consequences. Operational readiness for known and unknown hazards and emergencies requires a risk-informed and structured approach to building capacities within organizations such as WHO offices and national ministries of health. Under the flagship priority programme on emergency risk management of the WHO Regional Office for South-East Asia, a readiness training programme consisting of four modules was implemented during 2017-2018, involving staff from WHO country offices as well as from the regional office. The experience of and lessons learnt from designing, developing and delivering this phased training programme have fed into improvements in the curriculum and training methodology. The training programme has also facilitated the development of business continuity plans and contingency plans in some of the 11 Member States of the region and has increased the readiness of WHO staff for swift deployment in recent emergencies. It is recommended that the strengthening of operational readiness for responding to emergencies in the region be sustained and accelerated through the development of a regional training consortium that can scale the training programme up at national level, taking into account country contexts, national health systems and the needs of populations. The resilience of the populations and health systems in the region will be increased if disaster risk reduction and emergency preparedness and response activities are supported by operational readiness., Competing Interests: None
- Published
- 2020
- Full Text
- View/download PDF
42. Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation-a phase I/II study.
- Author
-
Roex MCJ, van Balen P, Germeroth L, Hageman L, van Egmond E, Veld SAJ, Hoogstraten C, van Liempt E, Zwaginga JJ, de Wreede LC, Meij P, Vossen ACTM, Danhof S, Einsele H, Schaafsma MR, Veelken H, Halkes CJM, Jedema I, and Falkenburg JHF
- Subjects
- Adenoviridae Infections prevention & control, Adult, Aged, Antigens, Neoplasm immunology, CD8-Positive T-Lymphocytes cytology, Cytomegalovirus Infections prevention & control, Epstein-Barr Virus Infections prevention & control, Feasibility Studies, Female, Hematologic Neoplasms complications, Hematologic Neoplasms immunology, Humans, Immunotherapy, Male, Middle Aged, Minor Histocompatibility Antigens immunology, Patient Safety, Transplantation, Homologous, Hematologic Neoplasms therapy, Stem Cell Transplantation, T-Lymphocytes immunology
- Abstract
Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell transplantation (TCD-alloSCT). In this phase I/II study, we aimed to reduce the risk of viral complications and disease relapses by administrating donor-derived CD8
pos T cells directed against cytomegalovirus (CMV), Epstein-Barr virus (EBV) and adenovirus antigens, tumor-associated antigens (TAA) and minor histocompatibility antigens (MiHA). Twenty-seven of thirty-six screened HLA-A*02:01pos patients and their CMVpos and/or EBVpos donors were included. Using MHC-I-Streptamers, 27 T-cell products were generated containing a median of 5.2 × 106 cells. Twenty-four products were administered without infusion-related complications at a median of 58 days post alloSCT. No patients developed graft-versus-host disease during follow-up. Five patients showed disease progression without coinciding expansion of TAA/MiHA-specific T cells. Eight patients experienced CMV- and/or EBV-reactivations. Four of these reactivations were clinically relevant requiring antiviral treatment, of which two progressed to viral disease. All resolved ultimately. In 2/4 patients with EBV-reactivations and 6/8 patients with CMV-reactivations, viral loads were followed by the expansion of donor-derived virus target-antigen-specific T cells. In conclusion, generation of multi-antigen-specific T-cell products was feasible, infusions were well tolerated and expansion of target-antigen-specific T cells coinciding viral reactivations was illustrated in the majority of patients.- Published
- 2020
- Full Text
- View/download PDF
43. Incidence of depression in patients with hepatitis C treated with direct-acting antivirals.
- Author
-
Egmond E, Mariño Z, Navines R, Oriolo G, Pla A, Bartres C, Lens S, Forns X, and Martin-Santos R
- Subjects
- Adult, Aged, Female, Hepatitis C epidemiology, Humans, Incidence, Logistic Models, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Ribavirin therapeutic use, Risk Factors, Spain epidemiology, Time Factors, Treatment Outcome, Antiviral Agents therapeutic use, Depressive Disorder epidemiology, Hepatitis C drug therapy, Hepatitis C psychology
- Abstract
Objective: Depression has been associated with hepatitis C, as well as with its treatment with proinflammatory cytokines (i.e., interferon). The new direct-acting antiviral agents (DAAs) have minimal adverse effects and high potency, with a direct inhibitory effect on non-structural viral proteins. We studied the incidence and associated factors of depression in a real-life prospective cohort of chronic hepatitis C patients treated with the new DAAs., Methods: The sample was recruited from a cohort of 91 patients with hepatitis C, of both sexes, with advanced level of fibrosis and no HIV coinfection, consecutively enrolled during a 6-month period for DAA treatment; those euthymic at baseline (n=54) were selected. All were evaluated through the depression module of the Patient Health Questionnaire (PHQ-9-DSM-IV), at three time points: baseline, 4 weeks, and end-of-treatment., Results: The cumulative incidence (95%CI) of major depression and any depressive disorder during DAA treatment was 13% (6.4-24.4) and 46.3% (33.7-59.4), respectively. No differences were observed between those patients with and without cirrhosis or ribavirin treatment (p > 0.05). Risk factors for incident major depression during DAA treatment included family depression (relative risk 9.1 [1.62-51.1]), substance use disorder (11.0 [1.7-73.5]), and baseline PHQ-9 score (2.1 [1.1-3.1])., Conclusions: The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors.
- Published
- 2020
- Full Text
- View/download PDF
44. Preoperative Sildenafil administration in children undergoing cardiac surgery: a randomized controlled preconditioning study.
- Author
-
Walavalkar V, Evers E, Pujar S, Viralam K, Maiya S, Frerich S, John C, Rao S, Reddy C, Spronck B, Prinzen FW, Delhaas T, and Vanagt WY
- Subjects
- Adolescent, Blood Pressure drug effects, Cardiac Surgical Procedures mortality, Cardiac Surgical Procedures statistics & numerical data, Child, Child, Preschool, Female, Heart drug effects, Heart physiopathology, Heart Defects, Congenital surgery, Humans, Infant, Ischemic Preconditioning, Myocardial mortality, Ischemic Preconditioning, Myocardial statistics & numerical data, Male, Sildenafil Citrate administration & dosage, Sildenafil Citrate pharmacology, Cardiac Surgical Procedures adverse effects, Cardiac Surgical Procedures methods, Ischemic Preconditioning, Myocardial adverse effects, Ischemic Preconditioning, Myocardial methods, Sildenafil Citrate therapeutic use
- Abstract
Objectives: Sildenafil has strong cardiac preconditioning properties in animal studies and has a safe side-effect profile in children. Therefore, we evaluated the application of Sildenafil preconditioning to reduce myocardial ischaemia/reperfusion injury in children undergoing surgical ventricular septal defect (VSD) closure., Methods: This is a randomized, double-blind study. Children (1-17 years) undergoing VSD closure were randomized into three groups: placebo (Control group), preconditioning with 0.06 mg/kg (Sild-L group) and 0.6 mg/kg Sildenafil (Sild-H group)., Primary Endpoint: troponin release. CK-MB, Troponin I, inflammatory response (IL-6 and TNF-α), bypass and ventilation weaning times, inotropy score and echocardiographic function were assessed. Data expressed as median (range), and a value of P < 0.05 was considered significant., Results: Thirty-nine patients were studied (13/group). Aortic cross-clamp time was similar [27 (18-85) and 27 (12-39) min] in the Control and Sild-L groups, respectively, but significantly longer [39 (20-96) min] in the Sild-H group when compared with the Control group. Area under the curve of CK-MB release was 1105 (620-1855) h ng/ml in the Control group, 1672 (564-2767) h ng/ml in the Sild-L group and was significantly higher in the Sild-H group [1695 (1252-3377) h ng/ml] when compared with the Control group. There were no significant differences in inflammatory response markers, cardiopulmonary bypass and ventilation weaning times, inotropy scores and echocardiographic function between the groups., Conclusions: In this small study, Sildenafil failed to reduce myocardial injury in children undergoing cardiac surgery, nor does it alter cardiac function, inotropic needs or postoperative course. A subclinical increase in cardiac enzyme release after Sildenafil preconditioning cannot be excluded., Clinical Trials Registry: CTRI/2014/03/004468., (© The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
45. Optimizing patient care and research: the Amsterdam Dementia Cohort.
- Author
-
van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, and Scheltens P
- Subjects
- Academic Medical Centers methods, Aged, Cohort Studies, Critical Pathways, Early Diagnosis, Female, Humans, Internet, Male, Middle Aged, Netherlands, Alzheimer Disease diagnosis, Alzheimer Disease pathology, Alzheimer Disease physiopathology, Alzheimer Disease therapy, Biomedical Research methods, Dementia diagnosis, Dementia pathology, Dementia physiopathology, Dementia therapy, Patient Care methods
- Abstract
Since its opening in 2000, patient care and research go hand in hand at the Alzheimer center of the VU University Medical Center, both organized in such a way that they mutually strengthen each other. Our mission is to give patients a voice by lifting the stigma on dementia, to find new diagnostic and treatment strategies, and, ultimately, to cure diseases that cause dementia. Our healthcare pathway is uniquely designed to accommodate all necessary investigations for the diagnostic work-up of dementia in one day (one-stop shop). A second unique feature is that research has been fully integrated in the healthcare pathway. The resulting Amsterdam Dementia Cohort now includes over 4000 patients, and for the majority of these, we have MRI, EEG, blood (serum, plasma), DNA, and CSF available. The Amsterdam Dementia Cohort forms the basis of much of our research, which focuses on four major research lines: 1) variability in manifestation, 2) early diagnosis, 3) vascular factors, and 4) interventions. By answering research questions closely related to clinical practice, the results of our research can be looped back to improve clinical work-up for our patients.
- Published
- 2014
- Full Text
- View/download PDF
46. Transplantation procedures in children with primary hyperoxaluria type 1: outcome and longitudinal growth.
- Author
-
Brinkert F, Ganschow R, Helmke K, Harps E, Fischer L, Nashan B, Hoppe B, Kulke S, Müller-Wiefel DE, and Kemper MJ
- Subjects
- Child, Child, Preschool, Follow-Up Studies, Humans, Infant, Kidney Failure, Chronic diagnosis, Liver Transplantation mortality, Liver Transplantation statistics & numerical data, Longitudinal Studies, Survival Analysis, Survivors, Treatment Outcome, Growth physiology, Hyperoxaluria, Primary surgery, Liver Transplantation physiology
- Abstract
Background: Cure of the metabolic defect in primary hyperoxaluria type 1 (PH1) is possible with liver transplantation (LTx). Preemptive LTx (PLTx) was promoted to prevent chronic kidney disease due to nephrocalcinosis and urolithiasis. However, timing of this procedure is difficult in view of the heterogeneity of PH1 and effective conservative treatment. Combined liver-kidney transplantation (LKTx) is able to cure metabolic defect and replace renal function at the same time and is effective and indicated for patients with or approaching end-stage renal disease (ESRD). Sometimes a sequential approach for LKTx (first liver, then kidney) has been recommended., Methods: We report on 13 patients with PH1 since 1995 who underwent transplantation procedures in our center for PH1 at a median age of 4.7 (range 1.4-8.9) years., Results: The first two patients, planned for a sequential strategy, died early after LTx because of infectious complications. Four patients underwent PLTx at a median glomerular filtration rate of 65 (range 27-98) mL/min/1.73 m/day (Hoppe et al., Pediatr Nephrol 1996; 10: 488), and three patients still have sufficient residual renal function after a follow-up of median 11.6 years. Seven patients with ESRD received a combined LKTx, including four with infantile oxalosis, and three weighing less than 10 kg. There was no mortality and catch-up growth was observed in most patients., Conclusion: In summary and conclusion, transplantation procedures are challenging in PH1, but our results including growth data are encouraging. PLTx remains an option despite the difficulties in timing the procedure. LKTx is indicated for patients with ESRD and is possible even in patients with infantile oxalosis and may improve longitudinal growth.
- Published
- 2009
- Full Text
- View/download PDF
47. Chronic carbon monoxide exposure in young rats alters coronary vessel growth.
- Author
-
Penney DG, Giraldo AA, and Van Egmond EM
- Subjects
- Analysis of Variance, Animals, Arteries drug effects, Body Weight drug effects, Cardiomegaly chemically induced, Coronary Vessels growth & development, Heart drug effects, Heart growth & development, Heart Septum drug effects, Heart Ventricles drug effects, Male, Organ Size drug effects, Rats, Rats, Sprague-Dawley, Veins drug effects, Carbon Monoxide toxicity, Coronary Vessels drug effects
- Abstract
The goal of this study was to determine whether chronic monoxide exposure in the developing heart produces long-lasting coronary vasculature alterations. One-day-old male rat pups were exposed to 500 ppm CO continuously for 30 d, while littermate controls remained in room air (AIR). At 61 and 110 d of age hearts were removed, perfusion fixed, x-rayed, and processed for analysis of coronary vessel architecture. Body weight (BW) and heart weight (HW) increased with age; the ratio of HW/BW decreased. There were no differences in HW and ventricular dimensions at either age due to prior CO exposure. Morphometric analysis of the fixed hearts from CO-exposed and AIR rats revealed no significant individual group differences in the number of small (27-114 microns) or larger (> 114 microns) vessels in any heart region. The septum (S) in CO rats was an exception: There were more small veins at 61 d of age and more larger veins at 110 d of age. There was a significant increase in the number of small arteries at both ages in the CO rats across all heart regions, and in the smaller veins at 61 d of age. The large vessels in the S at 61 d of age had a significantly greater diameter in CO compared to AIR rats. This was also true for the large arteries in the S and right ventricle (RV) of the 110-d-old rats. Taking all heart regions together, the large arteries in CO rats were larger than in AIR rats. Previous CO exposure significantly increased large artery and total cross-sectional area in the S and RV at 61 d of age, and in RV at 110 d of age. Total cross-sectional area of veins in the S was also increased. Taking all heart regions together, CO significantly increased small artery cross-sectional area at 61 d of age, and small, large, and total artery cross-sectional area at 110 d of age. With one exception (small veins, 110 d of age), there was no effect of CO on vein cross-sectional area. These changes resulted in the percentage of total cross-sectional area contributed by the larger vessels being increased. Pathological examination showed nothing abnormal. The results suggest profound and persistent changes in coronary vessel architecture following chronic neonatal CO exposure.
- Published
- 1993
- Full Text
- View/download PDF
48. Mass spectrometric quantification of traces of volatile N-nitrosamines in meat products.
- Author
-
Stephany RW, Freudenthal J, Egmond E, Gramberg LG, and Schuller PL
- Subjects
- Animals, Diethylnitrosamine analysis, Dimethylnitrosamine analysis, Evaluation Studies as Topic, Gas Chromatography-Mass Spectrometry methods, Netherlands, Piperidines analysis, Pyrrolidines analysis, Swine, Meat analysis, Nitrosamines analysis
- Published
- 1976
- Full Text
- View/download PDF
49. N-nitrosamines and residual nitrite in cured meats from the Dutch market.
- Author
-
Ellen G, Egmond E, and Sahertian ET
- Subjects
- Animals, Cattle, Netherlands, Swine, Meat analysis, Nitrites analysis, Nitrosamines analysis
- Abstract
A total of 140 samples of 16 kinds of cured meats were analyzed for contents of residual nitrite and N-nitrosamines. Nitrite was determined by reaction with sulfanilamide/naphthylethylenediamine and colorimetric measurement. N-nitrosamines were isolated from the samples by vacuum distillation and determined by gas-chromatography with chemiluminescence detection (GC-TEA). In six samples no nitrite was detectable (less than 1 mg NaNO2/kg), the remaining samples contained 1-140 mg NaNO2/kg, median value 6.8 mg/kg. In 46 samples (33%) no N-nitrosamines were detected, i.e. less than 0.1-0.5 microgram/kg of the individual nitrosamines, depending upon their structure. N-nitrosodimethylamine (NDMA) was the nitrosamine present most frequently, in 75 samples, contents were 0.1-0.9 microgram/kg, mean 0.3 microgram/kg. Other N-nitrosamines found were: N-nitrosopiperidine (NPIP), 10 times, 0.3-25 micrograms/kg; N-nitrosodiethylamine (NDEA), three times, 0.2-0.9 microgram/kg; N-nitrosopyrrolidine (NPYR), three times, 1.3-4.2 micrograms/kg; N-nitrosomorpholine, once, 0.7 microgram/kg and N-nitrosothiazolidine (NTHZ), 36 times, 0.5-91 micrograms/kg, mean 5.7 micrograms/kg. NTHZ was found most often and with the highest contents in smoked products. Frying of bacon and cured, smoked pork bellies led to substantially increased levels of NPYR in both products, and for the pork bellies also of NTHZ. In five samples of cured, smoked pork bellies after frying NTHZ-contents of 3.6-490 micrograms/kg (mean 179) were found. No correlation between residual nitrite levels and N-nitrosamine contents could be established. Investigations during the nineteen seventies gave much higher levels for NDMA, NDEA, NPIP and NPYR in Dutch cured meats than now found; at that time NTHZ was not measured.
- Published
- 1986
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.