1. Successful preservation and transplant of warm ischaemic lungs from controlled donors after circulatory death by prolonged in situ ventilation during normothermic regional perfusion of abdominal organs
- Author
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Riccardo De Carlis, Mario Nosotti, Davide Tosi, Alberto Zanella, Paolo Tarsia, Alessandro Palleschi, E. Benazzi, Michele Colledan, Lorenzo Rosso, Marinella Zanierato, Palleschi, A, Tosi, D, Rosso, L, Zanella, A, De Carlis, R, Zanierato, M, Benazzi, E, Tarsia, P, Colledan, M, and Nosotti, M
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Extracorporeal Circulation ,Tissue and Organ Procurement ,Lung-donation after circulatory death project ,medicine.medical_treatment ,030230 surgery ,Inferior vena cava ,Ex vivo lung perfusion ,03 medical and health sciences ,0302 clinical medicine ,Ischemia ,Recombinant tissue plasminogen activator ,medicine.artery ,medicine ,Lung transplantation ,Humans ,Respiratory function ,Lung ,Retrospective Studies ,Cardiocirculatory death ,Circulatory determination of death ,Donation after circulatory death ,Superior vena cava ,business.industry ,Organ Preservation ,Middle Aged ,Tissue Donors ,Transplantation ,Perfusion ,Pulmonary artery ,medicine.anatomical_structure ,medicine.vein ,Anesthesia ,Breathing ,Abdomen ,030211 gastroenterology & hepatology ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES Donation after circulatory death (DCD) potentially provides transplantable lungs suitable for a transplant, but in Italy, the need for 20 min of a no-touch period after cardiac arrest for legal declaration of death poses real challenges to organ preservation. METHODS This is a single-institution, retrospective study using data collected prospectively between October and December 2017. After the approval of the multidisciplinary DCD study group of Regione Lombardia, Maastricht category III DCD donors became eligible for combined procurement of lungs and abdominal organs. Our group subsequently established a dedicated technical protocol. Our protocol consists of a non-rapid normothermic open-lung procurement process that takes place during abdominal normothermic regional perfusion, namely without pleural topical cooling before the start of pneumoplegia. After the lung is procured according to the technique described in the article, lung function is evaluated by ex vivo lung perfusion, which is run with the low-flow, open atrium, low haematocrit technique. RESULTS During the study, we managed 5 controlled DCDs. In 3 cases, the lungs were successfully transplanted. All 3 patients are alive after 1 year, with good respiratory function. CONCLUSIONS Our approach resulted in adequate lung preservation and successful transplants without detrimental effects on abdominal organ procurement, confirming the possibility of overcoming the obstacle of a long no-touch period in a DCD setting.
- Published
- 2019