223 results on '"Durek, Thomas"'
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2. Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
3. Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation
4. Nucleation of a key beta-turn promotes cyclotide oxidative folding
5. Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
6. Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox
7. Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA
8. Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1
9. Make it or break it: Plant AEPs on stage in biotechnology
10. Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
11. Tertiary amide bond formation by an engineered asparaginyl ligase.
12. Sortase‐Catalyzed Protein Domain Inversion.
13. Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization
14. Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
15. A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
16. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET
17. Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase
18. Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix
19. A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
20. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide).
21. Disulfide-rich macrocyclic peptides as templates in drug design
22. Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads.
23. Solid phase synthesis of peptide-selenoesters
24. Convergent Chemical Synthesis and High-Resolution X-Ray Structure of Human Lysozyme
25. Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.
26. Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor‑1 Agonists.
27. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels
28. Cystine Knot Peptides with Tuneable Activity and Mechanism.
29. Enzymatic C‐to‐C Protein Ligation.
30. Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
31. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3
32. Protein semi-synthesis: New proteins for functional and structural studies
33. Enzymatic C-Terminal Protein Engineering with Amines.
34. Asparaginyl Ligases: New Enzymes for the Protein Engineer's Toolbox.
35. Improved Asparaginyl‐Ligase‐Catalyzed Transpeptidation via Selective Nucleophile Quenching.
36. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.
37. An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides.
38. Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides.
39. Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase.
40. Nucleation of a key beta-turn promotes cyclotide oxidative folding.
41. Potent complement C3a receptor agonists derived from oxazole amino acids: Structure–activity relationships
42. Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists
43. Synthesis of fluorescently labeled mono-and diprenylated Rab7 GTpase
44. NaV1.6 regulates excitability of mechanosensitive sensory neurons.
45. Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide.
46. Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor‑1 Scaffold Attenuate Fibrinolysis in Plasma.
47. Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.
48. The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6.
49. Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro
50. Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor.
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