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Amidst the COVID-19, the use of technology in the learning environment was no longer a matter of choice. Forced by circumstance, educators had to adapt in order to see the academic year through. While for some, already used to an online modality, it was business as always, for others was the start of a journey through unfamiliar territory. This study inserts itself in such context. It presents and discusses results gathered through an online questionnaire about the perceptions and personal experiences of design educators in Higher Education (HE) caught in this move from in-class face-to-face onto online teaching. Objectively, it portrays how this shift impacted their ability to teach, the compromises made or alternatives sought, and views towards a more technologically enabled future in HE. From a more extensive reliance on Learning Management Systems (LMS), changes in the learning environment, and perspectives of near-future uses of Virtual Reality (VR) in distance education, this study covers uses of technology but also the identification of pain points influencing the overall experience, as well as positive perceptions and significant changes made to the learning environment. [ABSTRACT FROM AUTHOR]

Aim: This paper describes the design and rationale of multicenter practice‐based research that aims to develop and evaluate an innovative mobile health (mHealth) intervention programme directed to promote healthy behaviours and prevent adolescent obesity. Design: This study is designed as a non‐randomized controlled trial with a three‐arm structure. Methods: Twelve to 16 years old participants will be recruited from schools, with access to the Internet and smartphone/tablet devices. The intervention group will be invited to engage in the TeenPower mHealth programme and divided into two subgroups: Group A (additionally engaged in a structured school‐based intervention programme) and Group B (only engaged in the mHealth programme). The mHealth app includes educational resources, self‐monitoring, social support, interactive training modules and motivational tools. The control group will only follow the structured school‐based intervention programme. The intervention length will be 3 months, including the direct support of an interdisciplinary team (nursing, nutrition, sports, psychology, among others). This research was approved and funded in August 2017. Discussion: The positive evaluation of the intervention programme will stimulate the inclusion of technologies in the promotion of salutogenic behaviours and obesity prevention. Impact: Adolescent obesity reached epidemic proportions. It is urgent to find effective prevention strategies to induce change at the individual, family and community level. If effective, this protocol can be used by health and exercise professionals in improving community interventions tailored to teenagers. [ABSTRACT FROM AUTHOR]

This study examined the relative influence of environmental variables (corridor width and brightness) and signage (directional and exit signs), when presented in competition, on participants' route-choices in two situational variables (everyday vs. emergency), during indoor wayfinding in virtual environments. A virtual reality-based methodology was used. Thus, participants attempted to find a room (everyday situation) in a virtual hotel, followed by a fire-related emergency egress (emergency situation). Different behaviours were observed. In the everyday situation, for no-signs condition, participants choose mostly the wider and brighter corridors, suggesting a heavy reliance on the environmental affordances. Conversely, for signs condition, participants mostly complied with signage, suggesting a greater reliance on the signs rather than on the environmental cues. During emergency, without signage, reliance on environmental affordances seems to be affected by the intersection type. In the sign condition, the reliance on environmental affordances that started strong decreases along the egress route. Practitioner Summary:Virtual reality was used to study relative influence of environmental variables and signage, when in competition, on participants' route-choices in everyday and emergency situations. For everyday no-signs condition, findings suggested a reliance on environmental variables. For emergency sign condition, higher reliance on environmental variables was found for first three intersections. [ABSTRACT FROM PUBLISHER]

Objective: The aim of this article is to discuss how user experience (UX) evaluation can benefit from the use of virtual reality (VR).Background: UX is usually evaluated in laboratory settings. However, considering that UX occurs as a consequence of the interaction between the product, the user, and the context of use, the assessment of UX can benefit from a more ecological test setting. VR provides the means to develop realistic-looking virtual environments with the advantage of allowing greater control of the experimental conditions while granting good ecological validity.Method: The methods used to evaluate UX, as well as their main limitations, are identified.The currentVR equipment and its potential applications (as well as its limitations and drawbacks) to overcome some of the limitations in the assessment of UX are highlighted.Results: The relevance of VR for UX studies is discussed, and a VR-based framework for evaluating UX is presented.Conclusion: UX research may benefit from a VR-based methodology in the scopes of user research (e.g., assessment of users' expectations derived from their lifestyles) and human-product interaction (e.g., assessment of users' emotions since the first moment of contact with the product and then during the interaction).Application: This article provides knowledge to researchers and professionals engaged in the design of technological interfaces about the usefulness of VR in the evaluation of UX. [ABSTRACT FROM AUTHOR]

The glial cell line-derived neurotrophic factor (GDNF) was first identified as a survival factor for midhrain dopaminergic neurons, but additional studies provided evidences for a role as atrophic factor for other neurons of the central and peripheral nervous systems. GDNF regulates cellular activity through interaction with glycosyl-phosphatidylinositol-anchored cell surface receptors, GDNF family receptor-α1, which might signal through the transmembrane Ret tyrosine receptors or the neural cell adhesion molecule, to promote cell survival, neurite outgrowth, and synaptogenesis. The neuroprotective effect of exogenous GDNF has been shown in different experimental models of focal and global brain ischemia, by local administration of the trophic factor, using viral vectors carrying the GDNF gene and by transplantation of GDNF-expressing cells. These different strategies and the mechanisms contributing to neuroprotection by GDNF are discussed in this review. Importantly, neuroprotection by GDNF was observed even when administered after the ischemic injury. [ABSTRACT FROM AUTHOR]

Warnings are intended to reduce accidents caused by hazards. Behavioral compliance is the most important measure of warning effectiveness. However, in result of diverse circumstances (e.g., distraction, misuse, negligence), conflicting or ambiguous safety messages can be perceived. Since these are recurrent and can result in wrong behaviors encompassing severe consequences, such cases should be studied for safety purposes. We report findings on the participants' compliant behavior when performing a work-related task, while immersed in a virtual environment, and investigate the effect of conflicting messages on compliance with warnings. Two warnings (one regular and one with an appended out-of-order sign) and two types of signs (static and dynamic) were considered. The warning with the out-of-order sign configures the case of potentially conflicting messages. The gender effect was also investigated. The participants' behavior was assessed regarding to pushing a button as directed by the warnings. In the 'out-of-order' warning, compliance was higher in the dynamic situation (53.3%) than in the static one (3.3%). Comparing with the non-conflicting warning, compliance was higher for both situations (static: 76.7%; dynamic: 100%). Women complied more than men. Although these results have limitations in their generalization, they are nonetheless relevant and deserve to be studied further. [ABSTRACT FROM AUTHOR]

Previous studies suggest significant differences between navigating virtual environments in a life-like walking manner (i.e., using treadmills or walk-in-place techniques) and virtual navigation (i.e., flying while really standing). The latter option, which usually involves hand-centric devices (e.g., joysticks), is the most common in Virtual Reality-based studies, mostly due to low costs, less space and technology demands. However, recently, new interaction devices, originally conceived for videogames have become available offering interesting potentialities for research. This study aimed to explore the potentialities of the Nintendo Wii Balance Board as a navigation interface in a Virtual Environment presented in an immersive Virtual Reality system. Comparing participants' performance while engaged in a simulated emergency egress allows determining the adequacy of such alternative navigation interface on the basis of empirical results. Forty university students participated in this study. Results show that participants were more efficient when performing navigation tasks using the Joystick than with the Balance Board. However there were no significantly differences in the behavioral compliance with exit signs. Therefore, this study suggests that, at least for tasks similar to the studied, the Balance Board have good potentiality to be used as a navigation interface for Virtual Reality systems. [ABSTRACT FROM AUTHOR]

There is an increasing interest in multimodal technology-based warnings, namely those conveying speech-warning statements. This type of warning may be tailored to the situation as well as to the target user's characteristics. However, more information is needed on how to design these warnings in a way that ensures intelligibility, promotes compliance and reduces the potential for annoyance. In this context, this paper reports an exploratory study whose main purpose was to assist the selection of a synthesized voice for a subsequent compliance study with personalized (i.e., using the person's name) technologybased warnings using Virtual Reality. Participants were requested to listen to speech signals, gathered from a speech synthesizer and post-processed in order to change the pitch perception, and then these were evaluated by fulfilling the MOS-X questionnaire. After that, the participants ranked the voices according to their preference. The effects of the speaker's gender and voice pitch, on both ratings and ranking were assessed. The preference of the male and female listeners for a talker's voice gender was also investigated. The results show that participants mostly prefer as first choice the high-pitched female voice, which also gathered the highest overall score in the MOS-X questionnaire. No significant influence of the participants' gender was found on the assessed measures. [ABSTRACT FROM AUTHOR]

Behavioral compliance is usually considered the best measure of warning effectiveness. Researching behavioral effects is difficult to carry out, however, due to concerns for safety, ethics, and high costs. Researchers cannot expose participants to real hazards while conducting a research. A realistic scenario that appears risky but that actually has no risk is expensive to conduct in terms of money, time, and effort. This article reflects on the potential of Virtual Reality (VR) as a technique to investigate warning effectiveness, particularly behavioral compliance. VR may help to overcome several key constraints that have limited warning compliance research, such as hazards actually being manipulated. This article focuses on two information-processing stages that will most likely benefit from VR: attention and behavior. Increasingly realistic VR can provide high-quality Virtual Environments (VEs) for use in warnings research. VEs can provide ecological validity and experimental control while limiting actual physical harm. Advantages and limitations are reviewed. © 2010 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

The adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release from mouse chromaffin cells. The stimulatory effect of NPY mediated by NPY Y1 receptor activation was lost in the absence of extracellular Ca2+. On the other hand, inhibition of nitric oxide synthase and guanylyl cyclase also decreased the stimulatory effect of NPY. Moreover, catecholamine release stimulated by NPY or by the nitric oxide donor (NOC-18) was inhibited by mitogen-activated protein kinase (MAPK) and protein kinase C inhibitors. In summary, in mouse chromaffin cells, NPY evokes catecholamine release by the activation the NPY Y1 receptor, in a Ca2+-dependent manner, by activating mitogen-activated protein kinase and promoting nitric oxide production, which in turn regulates protein kinase C and guanylyl cyclase activation. [ABSTRACT FROM AUTHOR]

To clarify the role of P-type Ca2+ channels in catecholamine release from adrenal chromaffin cells we examined the concentration dependence of the effect of ω-agatoxin IVA on the release both of adrenaline and noradrenaline induced by a K+-evoked depolarization. ω-Agatoxin IVA caused a biphasic dose-dependent inhibition of secretion with a high-potency component (IC50<1 nM), responsible for 10–15% of catecholamine release evoked by 70 mM K+, and a low-potency component that accounted for about 40% of release, with IC50 values of 57 nM and 48 nM for noradrenaline and adrenaline release, respectively. The release of catecholamines from chromaffin cells was also inhibited dose dependently by ω-conotoxin MVIIC with IC50 values of 182 and 218 nM for noradrenaline and adrenaline release, respectively. The effects of 3 nM ω-agatoxin IVA and 3 μM ω-conotoxin MVIIC were additive, indicating that at the concentrations used the toxins were acting at independent sites, presumably, P- and Q-type Ca2+ channels. The blockade of Q-type channels inhibited the release of adrenaline (72 ± 4.1%) significantly more than the release of noradrenaline (50 ± 2.7%), suggesting a higher density or a closer coupling of these channels to exocytosis in adrenergic chromaffin cells. The blockade of P-type channels caused a greater inhibition of catecholamine secretion at low levels of K+-evoked depolarization and shorter times of stimulation than that observed at higher levels of stimulation. The contribution of Q-type channels to catecholamine secretion did not change significantly with the intensity of stimulation. The data show that two types of ω-agatoxin IVA-sensitive Ca2+ channels are coupled to catecholamine release in chromaffin cells, and that the contribution of P-type channels to secretion is larger at low levels of depolarization. [ABSTRACT FROM AUTHOR]