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106 results on '"Donnarumma L"'

2. Economic Consequences of Investing in Anti-HCV Antiviral Treatment from the Italian NHS Perspective: A Real-World-Based Analysis of PITER Data

Author

Marcellusi, Andrea, Viti, Raffaella, Kondili, Loreta A., Rosato, Stefano, Vella, Stefano, Mennini, Francesco Saverio, Kondili, L. A., Vella, S., Quaranta, M. G., Rosato, S., Tosti, M. E., Weimer, L. E., Ferrigno, L., D’Angelo, F., Falzano, L., Benedetti, A., Schiadà, L., Cucco, M., Giacometti, A., Brescini, L., Castelletti, S., Drenaggi, D., Mazzaro, C., Angarano, G., Milella, M., Di Leo, A., Rendina, M., Contaldo, A., Iannone, A., La Fortezza, F., Rizzi, M., Cologni, G., Bolondi, L., Benevento, F., Serio, I., Andreone, P., Caraceni, P., Guarneri, V., Margotti, M., Simonetti, G., Mazzella, G., Verucchi, G., Donati, V., Mian, Peter, Rimenti, G., Rossini, A., Contessi, G. B., Castelli, Fulvio, Zaltron, S., Spinetti, A., Odolini, S., Leandro, G., Cozzolongo, R., Zappimbulso, M., Russello, M., Benigno, R., Coco, C., Torti, C., Costa, C., Greco, G., Mazzitelli, M., Pisani, V., Cosco, Lucia, Quintieri, F., De Siena, Martina, Giancotti, F., Vecchiet, J., Falasca, K., Mastroianni, A., Apuzzo, G., Chidichimo, L., Foschi, F. G., Dall’Aglio, A. C., Libanore, M., Segala, D., Sighinolfi, L., Bartolozzi, D., Salomoni, E., Blanc, P., Baragli, F., DelundefinedPin, B., Mariabelli, E., Mazzotta, F., Poggi, A., Zignego, A. L., Monti, M., Madia, Francesca, Xheka, A., Cela, E. M., Santantonio, T. A., Bruno, S. R., Viscoli, C., Alessandrini, A. I., Curti, C., DiundefinedBiagio, A., Nicolini, L. A., Balletto, E., Mastroianni, Chiara, Blerta, K., Prati, D., Raffaele, L., Andreoletti, M., Perboni, G., Costa, P., Manzini, L., Raimondo, G., Filomia, R., Lazzarin, A., Morsica, G., Salpietro, S., Puoti, M., Baiguera, C., Vassalli, S., Rumi, M. G., Labanca, S., Zuin, M., Giorgini, A., Orellana, D., D’ArminioundefinedMonforte, A., Debona, A., Solaro, S., Fargion, S., Valenti, L., Periti, G., Pelusi, S., Galli, M., Calvi, E., Milazzo, L., Peri, A., Lampertico, P., Borghi, Margherita, D’Ambrosio, R., Degasperi, E., Vinci, Maria Rosaria, Villa, E., Bernabucci, V., Bristot, Luca, Pereira, F., Chessa, L., Pasetto, M. C., Loi, M., Gori, A., Beretta, I., Pastore, V., Soria, A., Strazzabosco, M., Ciaccio, A., Gemma, M., Borgia, G., Foggia, A., Zappulo, E., Gentile, I., Buonomo, A. R., Abrescia, N., Maddaloni, A., Caporaso, N., Morisco, F., Camera, S., Donnarumma, L., Coppola, C., Amoruso, D. C., Staiano, L., Saturnino, M. R., Coppola, N., Martini, S., Monari, C., Federico, Alex, Dallio, M., Loguercio, C., Gaeta, G. B., Brancaccio, G., Nardone, G., Sgamato, C., D’Adamo, G., Alberti, A., Gonzo, M., Piovesan, S., Chemello, L., Buggio, A., Cavalletto, L., Barbaro, F., Castelli, Enrico, Floreani, A., Cazzagon, N., Franceschet, I., Russo, F. P., Zanetto, A., Franceschet, E., Madonia, S., Cannizzaro, Maria Chiara, Montalto, G., Licata, A., Capitano, A. R., Craxì, A., Petta, S., Calvaruso, V., Rini, F., Ferrari, C., Negri, E., Orlandini, A., Pesci, M., Bruno, R., Lombardi, A., Zuccaro, V., Gulminetti, R., Asti, A., Villaraggia, M., Mondelli, M., Ludovisi, S., Baldelli, F., Di Candilo, F., Parruti, G., Di Stefano, Paolo, Sozio, F., Gizzi, M. C., Brunetto, M. R., Colombatto, P., Coco, B., Surace, L., Foti, G., Pellicano, S., Fornaciari, G., Schianchi, S., Vignoli, P., Massari, M., Corsini, R., Garlassi, E., Ballardini, G., Andreoni, M., Cerva, C., Angelico, M., Gasbarrini, Antonio, Siciliano, M., Nosotti, L., Taliani, G., Biliotti, E., Santori, M., Spaziante, M., Tamburini, F., Vullo, V., D’Ettorre, G., Cavallari, E. N., Gebremeskel, T. S., Pavone, P., Cauda, Roberto, Cingolani, Antonella, Lamonica, S., D’Offizi, G., Lionetti, R., Visco Comandini, U., Grieco, Antonio, D’Aversa, F., Picardi, A., De Vincentis, A., Galati, G., Gallo, Patrizia, Dell’Unto, C., Aghemo, A., Gatti Comini, A., Persico, M., Masarone, M., Anselmo, M., De Leo, P., Marturano, Monia, Brunelli, E., Ridolfi, F., Schimizzi, A. M., Ayoubi Khajekini, M., Framarin, L., Di Perri, G., Cariti, G., Boglione, L., Cardellino, C., Marinaro, L., Saracco, G. M., Ciancio, A., Toniutto, P., Alterini, G., Capra, F., Ieluzzi, D., Marcellusi, A, Viti, R, Kondili, L, Rosato, S, Vella, S, Mennini, F, Quaranta, M, Tosti, M, Weimer, L, Ferrigno, L, D'Angelo, F, Falzano, L, Benedetti, A, Schiada, L, Cucco, M, Giacometti, A, Brescini, L, Castelletti, S, Drenaggi, D, Mazzaro, C, Angarano, G, Milella, M, Dileo, A, Rendina, M, Contaldo, A, Iannone, A, La Fortezza, F, Rizzi, M, Cologni, G, Bolondi, L, Benevento, F, Serio, I, Andreone, P, Caraceni, P, Guarneri, V, Margotti, M, Simonetti, G, Mazzella, G, Verucchi, G, Donati, V, Mian, P, Rimenti, G, Rossini, A, Contessi, G, Castelli, F, Zaltron, S, Spinetti, A, Odolini, S, Leandro, G, Cozzolongo, R, Zappimbulso, M, Russello, M, Benigno, R, Coco, C, Torti, C, Costa, C, Greco, G, Mazzitelli, M, Pisani, V, Cosco, L, Quintieri, F, Desiena, M, Giancotti, F, Vecchiet, J, Falasca, K, Mastroianni, A, Apuzzo, G, Chidichimo, L, Foschi, F, Dall'Aglio, A, Libanore, M, Segala, D, Sighinolfi, L, Bartolozzi, D, Salomoni, E, Blanc, P, Baragli, F, Delpin, B, Mariabelli, E, Mazzotta, F, Poggi, A, Zignego, A, Monti, M, Madia, F, Xheka, A, Cela, E, Santantonio, T, Bruno, S, Viscoli, C, Alessandrini, A, Curti, C, Dibiagio, A, Nicolini, L, Balletto, E, Mastroianni, C, Blerta, K, Prati, D, Raffaele, L, Andreoletti, M, Perboni, G, Costa, P, Manzini, L, Raimondo, G, Filomia, R, Lazzarin, A, Morsica, G, Salpietro, S, Puoti, M, Baiguera, C, Vassalli, S, Rumi, M, Labanca, S, Zuin, M, Giorgini, A, Orellana, D, D'Arminiomonforte, A, Debona, A, Solaro, S, Fargion, S, Valenti, L, Periti, G, Pelusi, S, Galli, M, Calvi, E, Milazzo, L, Peri, A, Lampertico, P, Borghi, M, D'Ambrosio, R, Degasperi, E, Vinci, M, Villa, E, Bernabucci, V, Bristot, L, Pereira, F, Chessa, L, Pasetto, M, Loi, M, Gori, A, Beretta, I, Pastore, V, Soria, A, Strazzabosco, M, Ciaccio, A, Gemma, M, Borgia, G, Foggia, A, Zappulo, E, Gentile, I, Buonomo, A, Abrescia, N, Maddaloni, A, Caporaso, N, Morisco, F, Camera, S, Donnarumma, L, Coppola, C, Amoruso, D, Staiano, L, Saturnino, M, Coppola, N, Martini, S, Monari, C, Federico, A, Dallio, M, Loguercio, C, Gaeta, G, Brancaccio, G, Nardone, G, Sgamato, C, D'Adamo, G, Alberti, A, Gonzo, M, Piovesan, S, Chemello, L, Buggio, A, Cavalletto, L, Barbaro, F, Castelli, E, Floreani, A, Cazzagon, N, Franceschet, I, Russo, F, Zanetto, A, Franceschet, E, Madonia, S, Cannizzaro, M, Montalto, G, Licata, A, Capitano, A, Craxi, A, Petta, S, Calvaruso, V, Rini, F, Ferrari, C, Negri, E, Orlandini, A, Pesci, M, Bruno, R, Lombardi, A, Zuccaro, V, Gulminetti, R, Asti, A, Villaraggia, M, Mondelli, M, Ludovisi, S, Baldelli, F, Di Candilo, F, Parruti, G, Di Stefano, P, Sozio, F, Gizzi, M, Brunetto, M, Colombatto, P, Coco, B, Surace, L, Foti, G, Pellicano, S, Fornaciari, G, Schianchi, S, Vignoli, P, Massari, M, Corsini, R, Garlassi, E, Ballardini, G, Andreoni, M, Cerva, C, Angelico, M, Gasbarrini, A, Siciliano, M, De Siena, M, Nosotti, L, Taliani, G, Biliotti, E, Santori, M, Spaziante, M, Tamburini, F, Vullo, V, D'Ettorre, G, Cavallari, E, Gebremeskel, T, Pavone, P, Cauda, R, Cingolani, A, Lamonica, S, D'Offizi, G, Lionetti, R, Visco Comandini, U, Grieco, A, D'Aversa, F, Picardi, A, De Vincentis, A, Galati, G, Gallo, P, Dell'Unto, C, Aghemo, A, Gatti Comini, A, Persico, M, Masarone, M, Anselmo, M, De Leo, P, Marturano, M, Brunelli, E, Ridolfi, F, Schimizzi, A, Ayoubi Khajekini, M, Framarin, L, Di Perri, G, Cariti, G, Boglione, L, Cardellino, C, Marinaro, L, Saracco, G, Ciancio, A, Toniutto, P, Alterini, G, Capra, F, Ieluzzi, D, Kondili LA, Vella S, Quaranta MG, Rosato S, Tosti ME, Weimer LE, Ferrigno L, D'Angelo F, Falzano L, Benedetti A, Schiadà L, Cucco M, Giacometti A, Brescini L, Castelletti S, Drenaggi D, Mazzaro C, Angarano G, Milella M, Di Leo A, Rendina M, Contaldo A, Iannone A, La Fortezza F, Rizzi M, Cologni G, Bolondi L, Benevento F, Serio I, Andreone P, Caraceni P, Guarneri V, Margotti M, Simonetti G, Mazzella G, Verucchi G, Donati V, Mian P, Rimenti G, Rossini A, Contessi GB, Castelli F, Zaltron S, Spinetti A, Odolini S, Leandro G, Cozzolongo R, Zappimbulso M, Russello M, Benigno R, Coco C, Torti C, Costa C, Greco G, Mazzitelli M, Pisani V, Cosco L, Quintieri F, De Siena M, Giancotti F, Vecchiet J, Falasca K, Mastroianni A, Apuzzo G, Chidichimo L, Foschi FG, Dall'Aglio AC, Libanore M, Segala D, Sighinolfi L, Bartolozzi D, Salomoni E, Blanc P, Baragli F, Del Pin B, Mariabelli E, Mazzotta F, Poggi A, Zignego AL, Monti M, Madia F, Xheka A, Cela EM, Santantonio TA, Bruno SR, Viscoli C, Alessandrini AI, Curti C, Di Biagio A, Nicolini LA, Balletto E, Mastroianni C, Blerta K, Prati D, Raffaele L, Andreoletti M, Perboni G, Costa P, Manzini L, Raimondo G, Filomia R, Lazzarin A, Morsica G, Salpietro S, Puoti M, Baiguera C, Vassalli S, Rumi MG, Labanca S, Zuin M, Giorgini A, Orellana D, D'Arminio Monforte A, Debona A, Solaro S, Fargion S, Valenti L, Periti G, Pelusi S, Galli M, Calvi E, Milazzo L, Peri A, Lampertico P, Borghi M, D'Ambrosio R, Degasperi E, Vinci M, Villa E, Bernabucci V, Bristot L, Pereira F, Chessa L, Pasetto MC, Loi M, Gori A, Beretta I, Pastore V, Soria A, Strazzabosco M, Ciaccio A, Gemma M, Borgia G, Foggia A, Zappulo E, Gentile I, Buonomo AR, Abrescia N, Maddaloni A, Caporaso N, Morisco F, Camera S, Donnarumma L, Coppola C, Amoruso DC, Staiano L, Saturnino MR, Coppola N, Martini S, Monari C, Federico A, Dallio M, Loguercio C, Gaeta GB, Brancaccio G, Nardone G, Sgamato C, D'Adamo G, Alberti A, Gonzo M, Piovesan S, Chemello L, Buggio A, Cavalletto L, Barbaro F, Castelli E, Floreani A, Cazzagon N, Franceschet I, Russo FP, Zanetto A, Franceschet E, Madonia S, Cannizzaro M, Montalto G, Licata A, Capitano AR, Craxì A, Petta S, Calvaruso V, Rini F, Ferrari C, Negri E, Orlandini A, Pesci M, Bruno R, Lombardi A, Zuccaro V, Gulminetti R, Asti A, Villaraggia M, Mondelli M, Ludovisi S, Baldelli F, Di Candilo F, Parruti G, Di Stefano P, Sozio F, Gizzi MC, Brunetto MR, Colombatto P, Coco B, Surace L, Foti G, Pellicano S, Fornaciari G, Schianchi S, Vignoli P, Massari M, Corsini R, Garlassi E, Ballardini G, Andreoni M, Cerva C, Angelico M, Gasbarrini A, Siciliano M, De Siena M, Nosotti L, Taliani G, Biliotti E, Santori M, Spaziante M, Tamburini F, Vullo V, D'Ettorre G, Cavallari EN, Gebremeskel TS, Pavone P, Cauda R, Cingolani A, Lamonica S, D'Offizi G, Lionetti R, Visco Comandini U, Grieco A, D'Aversa F, Picardi A, De Vincentis A, Galati G, Gallo P, Dell'Unto C, Aghemo A, Gatti Comini A, Persico M, Masarone M, Anselmo M, De Leo P, Marturano M, Brunelli E, Ridolfi F, Schimizzi AM, Ayoubi Khajekini M, Framarin L, Di Perri G, Cariti G, Boglione L, Cardellino C, Marinaro L, Saracco GM, Ciancio A, Toniutto P, Alterini G, Capra F, Ieluzzi D., Marcellusi, A., Viti, R., Kondili, L. A., Rosato, S., Vella, S., Mennini, F. S., Quaranta, M. G., Tosti, M. E., Weimer, L. E., Ferrigno, L., D'Angelo, F., Falzano, L., Benedetti, A., Schiada, L., Cucco, M., Giacometti, A., Brescini, L., Castelletti, S., Drenaggi, D., Mazzaro, C., Angarano, G., Milella, M., Dileo, A., Rendina, M., Contaldo, A., Iannone, A., La Fortezza, F., Rizzi, M., Cologni, G., Bolondi, L., Benevento, F., Serio, I., Andreone, P., Caraceni, P., Guarneri, V., Margotti, M., Simonetti, G., Mazzella, G., Verucchi, G., Donati, V., Mian, P., Rimenti, G., Rossini, A., Contessi, G. B., Castelli, F., Zaltron, S., Spinetti, A., Odolini, S., Leandro, G., Cozzolongo, R., Zappimbulso, M., Russello, M., Benigno, R., Coco, C., Torti, C., Costa, C., Greco, G., Mazzitelli, M., Pisani, V., Cosco, L., Quintieri, F., Desiena, M., Giancotti, F., Vecchiet, J., Falasca, K., Mastroianni, A., Apuzzo, G., Chidichimo, L., Foschi, F. G., Dall'Aglio, A. C., Libanore, M., Segala, D., Sighinolfi, L., Bartolozzi, D., Salomoni, E., Blanc, P., Baragli, F., Delpin, B., Mariabelli, E., Mazzotta, F., Poggi, A., Zignego, A. L., Monti, M., Madia, F., Xheka, A., Cela, E. M., Santantonio, T. A., Bruno, S. R., Viscoli, C., Alessandrini, A. I., Curti, C., Dibiagio, A., Nicolini, L. A., Balletto, E., Mastroianni, C., Blerta, K., Prati, D., Raffaele, L., Andreoletti, M., Perboni, G., Costa, P., Manzini, L., Raimondo, G., Filomia, R., Lazzarin, A., Morsica, G., Salpietro, S., Puoti, M., Baiguera, C., Vassalli, S., Rumi, M. G., Labanca, S., Zuin, M., Giorgini, A., Orellana, D., D'Arminiomonforte, A., Debona, A., Solaro, S., Fargion, S., Valenti, L., Periti, G., Pelusi, S., Galli, M., Calvi, E., Milazzo, L., Peri, A., Lampertico, P., Borghi, M., D'Ambrosio, R., Degasperi, E., Vinci, M., Villa, E., Bernabucci, V., Bristot, L., Pereira, F., Chessa, L., Pasetto, M. C., Loi, M., Gori, A., Beretta, I., Pastore, V., Soria, A., Strazzabosco, M., Ciaccio, A., Gemma, M., Borgia, G., Foggia, A., Zappulo, E., Gentile, I., Buonomo, A. R., Abrescia, N., Maddaloni, A., Caporaso, N., Morisco, F., Camera, S., Donnarumma, L., Coppola, C., Amoruso, D. C., Staiano, L., Saturnino, M. R., Coppola, N., Martini, S., Monari, C., Federico, A., Dallio, M., Loguercio, C., Gaeta, G. B., Brancaccio, G., Nardone, G., Sgamato, C., D'Adamo, G., Alberti, A., Gonzo, M., Piovesan, S., Chemello, L., Buggio, A., Cavalletto, L., Barbaro, F., Castelli, E., Floreani, A., Cazzagon, N., Franceschet, I., Russo, F. P., Zanetto, A., Franceschet, E., Madonia, S., Cannizzaro, M., Montalto, G., Licata, A., Capitano, A. R., Craxi, A., Petta, S., Calvaruso, V., Rini, F., Ferrari, C., Negri, E., Orlandini, A., Pesci, M., Bruno, R., Lombardi, A., Zuccaro, V., Gulminetti, R., Asti, A., Villaraggia, M., Mondelli, M., Ludovisi, S., Baldelli, F., Di Candilo, F., Parruti, G., Di Stefano, P., Sozio, F., Gizzi, M. C., Brunetto, M. R., Colombatto, P., Coco, B., Surace, L., Foti, G., Pellicano, S., Fornaciari, G., Schianchi, S., Vignoli, P., Massari, M., Corsini, R., Garlassi, E., Ballardini, G., Andreoni, M., Cerva, C., Angelico, M., Gasbarrini, A., Siciliano, M., De Siena, M., Nosotti, L., Taliani, G., Biliotti, E., Santori, M., Spaziante, M., Tamburini, F., Vullo, V., D'Ettorre, G., Cavallari, E. N., Gebremeskel, T. S., Pavone, P., Cauda, R., Cingolani, A., Lamonica, S., D'Offizi, G., Lionetti, R., Visco Comandini, U., Grieco, A., D'Aversa, F., Picardi, A., De Vincentis, A., Galati, G., Gallo, P., Dell'Unto, C., Aghemo, A., Gatti Comini, A., Persico, M., Masarone, M., Anselmo, M., De Leo, P., Marturano, M., Brunelli, E., Ridolfi, F., Schimizzi, A. M., Ayoubi Khajekini, M., Framarin, L., Di Perri, G., Cariti, G., Boglione, L., Cardellino, C., Marinaro, L., Saracco, G. M., Ciancio, A., Toniutto, P., Alterini, G., Capra, F., Ieluzzi, D., Marcellusi, Andrea, Viti, Raffaella, Kondili, Loreta A., Rosato, Stefano, Vella, Stefano, Mennini, Francesco Saverio, Kondili, L.A., Quaranta, M.G., Tosti, M.E., Weimer, L.E., D’Angelo, F., Schiadà, L., Di&nbsp, Leo, A., Contessi, G.B., De&nbsp, Siena, M., Foschi, F.G., Dall’Aglio, A.C., Del&nbsp, Pin, B., Zignego, A.L., Cela, E.M., Santantonio, T.A., Bruno, S.R., Alessandrini, A.I., Biagio, A., Nicolini, L.A., Rumi, M.G., D’Arminio&nbsp, Monforte, A., D’Ambrosio, R., Pasetto, M.C., Buonomo, A.R., Amoruso, D.C., Saturnino, M.R., Gaeta, G.B., D’Adamo, G., Russo, F.P., Capitano, A.R., Craxì, A., Gizzi, M.C., Brunetto, M.R., D’Ettorre, G., Cavallari, E.N., Gebremeskel, T.S., D’Offizi, G., D’Aversa, F., Dell’Unto, C., Schimizzi, A.M., Saracco, G.M., Cosco, Alfredo, Dall’Aglio, A. C., Salomoni, Valentina, Nicolini, Elvira, Calvi, Marta, Soria, Giovanni, D'Adamo, Danilo, ALONSO ALBERTI, MARIA PALOMA CARMEN, Orlandini, Giovanni, DE ASTIS, Fabio, Sozio, Concetta, Terzini, Angelico, DE SIENA, ANDREA URIEL, Taliani, Sabrina, Spaziante, Agata, Lamonica, Emilia, and Capra, Carlo

Subjects
Liver Cirrhosis, Pediatrics, Time Factors, Settore MED/09 - Medicina Interna, National Health Programs, ERADICATION, OUTBREAK, antiviral treatment, anti HCV, economic consequences, Hepacivirus, LIVER FIBROSIS, Severity of Illness Index, Health Services Accessibility, COST-EFFECTIVENESS, Indirect costs, 0302 clinical medicine, Epidemiology, virus infection, 030212 general & internal medicine, health care economics and organizations, cost effectiveness, 030503 health policy & services, Health Policy, Health services research, health, Hepatitis C, Markov Chains, chronic hepatitis C, virus infection, fibrosis progression, cost effectiveness, liver fibrosis, Italy, Pharmacology, Public Health, Environmental and Occupational Health, Cohort, Settore SECS-P/03 - Scienza delle Finanze, Disease Progression, Public Health, 0305 other medical science, Viral hepatitis, Anti-HCV antiviral treatment, CHRONIC HEPATITIS-C, medicine.medical_specialty, Genotype, Settore MED/12 - GASTROENTEROLOGIA, VIRUS-INFECTION, Antiviral Agents, NO, 03 medical and health sciences, Cost Savings, Humans, medicine, MANAGEMENT, chronic hepatitis C, INDUCED DISEASES, METAANALYSIS, Health economics, business.industry, Public health, Environmental and Occupational Health, medicine.disease, FIBROSIS PROGRESSION, business
Abstract

OBJECTIVE:\ud We estimated the cost consequence of Italian National Health System (NHS) investment in direct-acting antiviral (DAA) therapy according to hepatitis C virus (HCV) treatment access policies in Italy.\ud \ud METHODS:\ud A multistate, 20-year time horizon Markov model of HCV liver disease progression was developed. Fibrosis stage, age and genotype distributions were derived from the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. The treatment efficacy, disease progression probabilities and direct costs in each health state were obtained from the literature. The break-even point in time (BPT) was defined as the period of time required for the cumulative costs saved to recover the Italian NHS investment in DAA treatment. Three different PITER enrolment periods, which covered the full DAA access evolution in Italy, were considered.\ud \ud RESULTS:\ud The disease stages of 2657 patients who consecutively underwent DAA therapy from January 2015 to December 2017 at 30 PITER clinical centres were standardized for 1000 patients. The investment in DAAs was considered to equal €25 million, €15 million, and €9 million in 2015, 2016, and 2017, respectively. For patients treated in 2015, the BPT was not achieved, because of the disease severity of the treated patients and high DAA prices. For 2016 and 2017, the estimated BPTs were 6.6 and 6.2 years, respectively. The total cost savings after 20 years were €50.13 and €55.50 million for 1000 patients treated in 2016 and 2017, respectively.\ud \ud CONCLUSIONS:\ud This study may be a useful tool for public decision makers to understand how HCV clinical and epidemiological profiles influence the economic burden of HCV.

Published
2019

8. Roadmap to the management of marine invasive alien species in Europe: a prioritization exercise in a Mediterranean country

Author

Marchini A., Cardeccia A., Andaloro F., Azzurro E., Carnevali L., Castelli A., Cecere E., Donnarumma L., Ferrario J., Genovesi P., Giangrande A., Gravili C., Grieco F., Lange-neck J., Mancinelli G., Mastrototaro F., Mazziotti C., Mistri M., Montesanto F., Munari C., Orsi-Relini L., Petrocelli A., Piazzi L., Relini G., Russo G.F., Sfriso A., Occhipinti-Ambrogi A., Marchini, Agnese, Cardeccia, Alice, Andaloro, Franco, Azzurro, Ernesto, Carnevali, Lucilla, Castelli, Alberto, Cecere, Ester, Donnarumma, Luigia, Ferrario, Jasmine, Genovesi, Piero, Giangrande, Adriana, Gravili, Cinzia, Grieco, Flavia, Langeneck, Joachim, Mancinelli, Giorgio, Mastrototaro, Francesco, Mazziotti, Cristina, Mistri, Michele, Montesanto, Federica, Munari, Cristina, Orsi-Relini, Lidia, Petrocelli, Antonella, Piazzi, Luigi, Relini, Giulio, Fulvio Russo, Giovanni, Sfriso, Adriano, and Occhipinti, ANNA CARMEN

Subjects
prioritizing, alien species, marine species, invasive species
Abstract

Until 2014, the management of invasive alien species has been poorly addressed in Europe. Recently, the Regulation 1143/14 on invasive alien species (IAS) was issued by the European Community. A first list of "IAS of Union Concern" was presented in 2016 and subsequently updated in 2017. The species included in that list are subjected to a number of commercial restrictions, and EU member states are required to control or eradicate them. The inclusion of an IAS in this list is based on the results of a risk-assessment procedure. At present, this list contains 49 IAS, none of which marine. Member states can decide either to adopt the EU list as it is, or to integrate it with additional "IAS of national concern". Italy has opted for the second way and is currently developing its own national list, which may eventually include marine IAS. Italy is a major "first hub" for marine introductions in the Mediterranean Sea, with over 200 multicellular marine alien species reported so far. Italy, with its central position in the Mediterranean Sea, shares several species with the Western European countries, carried by ships or with shellfish stocks, as well as a number of Indo-Pacific species with the Eastern Mediterranean countries, entered through the Suez Canal. Therefore, the roadmap that Italy is currently tracing towards the possible inclusion of marine species in the list of IAS to be managed and controlled, is also relevant for other European and Mediterranean countries. This presentation will show how the process has been organized and conducted, and the preliminary outcomes

Published
2018

9. Prioritizing invasive alien species in Italy: screening of marine alien species

Author

Marchini A., Cardeccia A., Andaloro F., Azzurro E., Carnevali L., Castelli A., Cecere E., Donnarumma L., Ferrario J., Genovesi P., Giangrande A., Gravili C., Grieco F., Lange-neck J., Mancinelli G., Mastrototaro F., Mazziotti C., Mistri M., Montesanto F., Munari C., Orsi-Relini L., Petrocelli A., Piazzi L., Relini G., Russo G.F., Sfriso A., and Occhipinti-Ambrogi A.

Subjects
prioritizing, Italy, alien species, marine species, invasive species
Abstract

Si riportano i primi risultati dell'esercizio di prioritizzazione delle specie aliene dei mari italiani condotto per conto di ISPRA dagli esperti dei singoli gruppi tassonomici iscritti al Gruppo Alloctone della Società Italiana di Biologia Marina

Published
2018

10. Red coral (Corallium rubrum) populations and coralligenous characterization within "Regno di Nettuno MPA" (Tyrrhenian Sea, Italy).

Author

Ferrigno, F., Appolloni, L., Rendina, F., Donnarumma, L., Russo, G. F., and Sandulli, R.

Subjects
RED, HABITATS, INFORMATION measurement
Abstract

Red coral is one of the most important species belonging to the coralligenous habitats, being a structuring organism and highly sensitive to human pressure. The presence of red coral populations is historically well documented along the Campania coast (Tyrrhenian Sea), and, due to its high economic value, it has been commercially overharvested since ancient times. Red coral populations along several cliffs on the "Regno di Nettuno" MPA of the Gulf of Naples were investigated using ROV-imaging techniques. Coralligenous habitats were characterized in terms of percent cover and number of morphological groups. Pizzaco site showed the richest and most diverse community. Density of red coral colonies was calculated and compared with morphometric parameters. Results show an inversely correlated trend between colonies density and their size. Finally, fishing pressure was estimated through frequency of lost fishing gears, and S. Angelo site resulted the most stressed one. Anthropic stress plays a key role in the degradation of coralligenous habitats and the dramatic reduction of red coral populations recorded in recent years allows to suspect a more extensive degradation of the entire community. An assessment of the distribution and state of the populations can provide useful information to take measures for a better MPAs management. [ABSTRACT FROM AUTHOR]

Published
2020
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12. VIRONET-C real life experience of resistance-guided retreatment in HCV infected patients who previously failed a NS5A inhibitor-containing regimen

Author

Di Maio, V.C., Aragri, M., Masetti, C., Paolucci, S., Bruzzone, B., Degasperi, E., Barbaliscia, S., Pollicino, T., Minichini, C., Calvaruso, V., Rendina, M., Cento, V., Teti, E., Micheli, V., Allice, T., Polilli, E., Palitti, V. Pace, Landonio, S., Lenci, I., Francioso, S., Donnarumma, L., Nicolini, L.A., Bertoli, A., Starace, M., Pasquazzi, C., Callegaro, A.P., Morisco, F., Cenderello, G., Marenco, S., Gulminetti, R., Novati, S., Scuteri, A., Andreone, P., Galli, S., Ciancio, A., Sangiovanni, V., Cuomo, N., Raddi, A., Gennari, W., Boeri, E., Morsica, G., Hasson, H., Borghi, V., Maida, I., Brunetto, M., Colombatto, P., Cozzolongo, R., De Santis, A., Lichtner, M., Babudieri, S., Biliotti, E., Taliani, G., Santantonio, T., Di Stefano, M., Paternoster, C., Ganga, R., Merli, M., Rizzardini, G., Pellicelli, A., Giannelli, V., Milano, E., Mastroianni, C., Licata, A., Di Lorenzo, F., Giorgini, A., Sighinolfi, L., Dentone, C., Lleo, A., Rossetti, B., Beretta, I., Cariti, G., Ghisetti, V., Lampertico, P., Parruti, G., Coppola, N., Baldanti, F., Gaeta, G.B., Raimondo, G., Puoti, M., Zazzi, M., Andreoni, M., Angelico, M., Perno, C.F., Craxì, A., and Ceccherini-Silberstein, F.

Published
2020
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14. Population ecology of Jujubinus striatus and Jujubinus exasperatus (Gastropoda: Trochidae) in a Posidonia oceanica seagrass bed.

Author

Donnarumma, L., Bruno, R., Terlizzi, A., and Russo, G. F.

Subjects
*POPULATION ecology, *POSIDONIA oceanica, *AQUATIC plants, *SEAGRASSES
Abstract

The population structure of Jujubinus striatus and Jujubinus exasperatus (Trochidae), common gastropod grazers of Posidonia oceanica leaves, was investigated in the seagrass bed off Lacco Ameno of Ischia (Gulf of Naples). Sampling was performed monthly, from July 1981 to June 1982, at five stations along a depth gradient (1, 3, 10, 15 and 25 m), using a hand-towed net. Throughout the study period, both populations were characterised by seasonal fluctuations in abundance, with a total of 550 individuals counted and measured. The two populations analysed showed different distributional trends along the depth gradient. Jujubinus striatus settled and occurred mainly at shallower stands (1-3 m depth), while J. exasperatus was found deeper (10-15 m). Both species are semelparous. Juveniles and small individuals (shell height < 4 mm) were mainly found during the late winter and early spring months. The survivorship curves of both Jujubinus species showed a very low mortality rate in the first few months after settlement. Demographic analysis suggests an indeterminate growth rate after sexual maturity, with a lifespan of about 22 months for J. striatus and 17 months for J. exasperatus. For both species the growth rate is fast during the first couple of months after settlement. The findings of this study, compared with earlier work, reveal a certain number of shared traits in the life cycle of the most common gastropod species living on the leaves of P. oceanica seagrass: semelparous reproduction, spring settlement, fast early growth and short lifespan (2 years maximum). [ABSTRACT FROM AUTHOR]

Published
2018
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15. Resistance test guided retreatment of HCV infected patients with a previous failure to a NS5A inhibitor-containing regimen: the Italian Vironet C real life experience

Author

Di Maio, V.C., Aragri, M., Masetti, C., Paolucci, S., Bruzzone, B., Degasperi, E., Barbaliscia, S., Pollicino, T., Minichini, C., Calvaruso, V., Rendina, M., Cento, V., Teti, E., Micheli, V., Ghisetti, V., Polilli, E., Palitti, V. Pace, Landonio, S., Lenci, I., Donnarumma, L., Nicolini, L.A., Bertoli, A., Starace, M., Pasquazzi, C., Callegaro, A.P., Morisco, F., Cenderello, G., Marenco, S., Gulminetti, R., Novati, S., Guarneri, V., Andreone, P., Galli, S., Ciancio, A., Sangiovanni, V., Cuomo, N., Raddi, A., Morsica, G., Borghi, V., Maida, I., Brunetto, M., Colombatto, P., Cozzolongo, R., De Santis, A., Lichtner, M., Babudieri, S., Taliani, G., Santantonio, T., Di Stefano, M., Paternoster, C., Ganga, R., Puoti, M., Rizzardini, G., Pellicelli, A., Milano, E., Mastroianni, C., Licata, A., Di Lorenzo, F., Giorgini, A., Lampertico, P., Parruti, G., Coppola, N., Zazzi, M., Raimondo, G., Andreoni, M., Craxì, A., Angelico, M., Perno, C.F., and Ceccherini-Silberstein, F.

Published
2019
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24. Population ecology of Gibbula umbilicaris and Gibbula ardens (Gastropoda: Trochidae) in a Posidonia oceanica seagrass bed.

Author

Donnarumma, L., Bruno, R., Terlizzi, A., and Russo, G. F.

Subjects
*TROCHIDAE, *POSIDONIA oceanica, *SEAGRASSES, *MOLLUSKS
Abstract

Population structures of the gastropodsGibbula umbilicarisandGibbula ardens(Trochidae), the two most common species of the genusGibbulaliving in shallow beds of the Mediterranean seagrassPosidonia oceanica, were investigated in the seagrass bed off Lacco Ameno of Ischia (Gulf of Naples), at six stations along a depth gradient (1, 3, 5, 10, 15 and 25 m). Sampling was performed on a monthly basis for 1 year. A total of 853 individuals were counted and measured. The two gastropod populations analysed show a rather similar distributional trend in all seasons and depths. Recruitment occurred at the shallowest stations (1–3 m depth), where the populations were characterised by higher values of abundance and biomass, confirming thatG. umbilicarisandG. ardensare typical species of the shallow community ofP. oceanicaseagrass beds. Juveniles were exclusively found in 1 month of the whole year:G. umbilicarisin April,G. ardensin July. The survivorship curves of bothGibbulaspecies, derived from the size-frequency distribution of shells, showed a very low mortality rate in the first months after settlement. Demographic analysis ofG. umbilicarissuggests a rather slow growth rate and a polymorphic maturation strategy with a lifespan of 1 year for most individuals, but lifespan may also reach about 2 years in a few specimens.Gibbula ardenshas a lifespan of about 1 year and a fast growth rate, especially during the first couple of months after settlement. Therefore, on the basis of lifespan and recruitment time, both species seem to be semelparous. [ABSTRACT FROM AUTHOR]

Published
2016
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25. P.17.8 CLINICAL FEATURES, THERAPEUTIC OUTCOME AND PREDICTOR OF RESPONSE IN HCV GENOTYPE 1A AND 1B: SIMILARITIES AND DIFFERENCES

Author

Morisco, F., Di Marco, V., Caporaso, N., Granata, R., Camera, S., Ippolito, A., Margaglione, M., Fattovich, G., Smedile, A., Clery, E., Ferraiuoli, C., Cossiga, V., Guarino, M., Donnarumma, L., Valvano, M.R., Milella, M., Felder, M.M., Gaeta, G.B., Gatti, P., Tundo, P., Barone, M., Cozzolongo, R., Angelico, M., Mazzella, G., Santantonio, T., and Andriulli, A.

Published
2014
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28. HCV genotype 1a and 1b: Similarities and differences in clinical features, therapeutic outcome and predictors of response

Author

Morisco, F., Di Marco, V., Caporaso, N., Granata, R., Camera, S., Ippolito, A., Margaglione, M., Fattovich, G., Smedile, A., Clery, E., Ferraiuoli, C., Guarino, M., Donnarumma, L., Valvano, M.R., Milella, M., Felder, M., Gaeta, G.B., Gatti, P., Tundo, P., Barone, M., Cozzolongo, R., Angelico, M., Mazzella, G., Santantonio, T., and Andriulli, A.

Published
2014
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36. Increased soluble P-selectin levels in hepatitis C virus-related chronic hepatitis: correlation with viral load.

Author

Ferroni, Patrizia, Mammarella, Antonio, Martini, Francesca, Paoletti, Vincenzo, Cardarello, Cristiano M., Labbadia, Giancarlo, Donnarumma, Lucia, Matteis, Antonio De, Gazzaniga, Pier Paolo, Musca, Antonino, Basili, Stefania, Ferroni, P, Mammarella, A, Martini, F, Paoletti, V, Cardarello, C M, Labbadia, G, Donnarumma, L, De Matteis, A, and Gazzaniga, P P

Subjects
ANTIGENS, BLOOD platelet activation, HIGH density lipoproteins, LOW density lipoproteins, RNA, VIRAL load, CHRONIC hepatitis C
Abstract

Background: Platelet functional abnormalities are commonly found in patients with chronic liver disease; however, their nature and clinical significance are still a matter of discussion.Methods: Soluble P-selectin (sP-selectin, a marker of in vivo platelet activation) levels, lipid pattern, and clotting activity were investigated in 39 patients with histologically confirmed chronic C hepatitis.Results: Serum factor VIIc (P < 0.01), total cholesterol (P < 0.005), high density lipoprotein (P < 0.001), and low density lipoprotein (P<0.05) levels were lower in patients compared with healthy subjects, whereas triglyceride and fibrinogen levels were similar in both groups. Platelet counts were lower in chronic hepatitis patients compared with controls (P < 0.0001), and approximately 20% of patients had thrombocytopenia (platelet counts < 110 x 10(3)/microL). Platelet-associated immunoglobulin G (PAIgG) was present in 30.8% of patients. Plasma sP-selectin levels were higher in hepatitis C patients compared with controls (P < 0.0001), and significant differences were observed with respect to the Scheuer score (P < 0.01). The analysis of the distribution of plasma sP-selectin showed the presence of higher levels in patients with low platelet counts compared with patients with normal platelet counts and controls (P < 0.0001); moreover, sP-selectin levels did not correlate with the presence of PAIgG. On the other hand, sP-selectin levels directly correlated with serum hepatitis C virus (HCV)-RNA (P < 0.05) and inversely correlated with platelet count, blood lipids, and factor VIIc.Conclusions: The results obtained in this study support the hypothesis that HCV infection might be directly responsible for a condition of in vivo platelet activation in patients with chronic C hepatitis. [ABSTRACT FROM AUTHOR]

Published
2001
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37. Natural history of cardiac involvement in myotonic dystrophy (Steinert's disease): a 13-year follow-up study.

Author

Mammarella, Antonio, Paradiso, Michele, Antonini, Giovanni, Paoletti, Vincenzo, Matteis, Antonio, Basili, Stefania, Donnarumma, Lucia, Labbadia, Giancarlo, Franco, Manuela, Musca, Antonino, Mammarella, A, Paradiso, M, Antonini, G, Paoletti, V, De Matteis, A, Basili, S, Donnarumma, L, Labbadia, G, Di Franco, M, and Musca, A

Abstract

Myotonic dystrophy (MD) is associated with a wide spectrum of cardiac abnormalities, but only a few longitudinal studies have investigated the natural course of heart disease in MD. To assess whether neuromuscular involvement significantly predicts cardiac disorders in MD, 83 patients with various grades of disease severity were enrolled in a 13-year follow-up study (mean, 60.6 +/- 37.8 months) that included periodic physical and instrumental cardiac examinations (standard and Holter electrocardiography, echocardiography). During follow-up, muscular disease worsened clinically in 9 patients (11%) whose baseline severity grade changed accordingly; only 3 of them demonstrated parallel worsening of cardiac disturbance, however, compared with a large number of patients who showed additional cardiac abnormalities. These included further worsening of pre-existing pathologic features (19/83) and the appearance de novo of serious arrhythmias and/or conduction defects (23/83). Pacemaker implantation was necessary in 11 of 83 patients (13.2%) who had symptomatic bradyarrhythmias, bifascicular block, and P-R prolongation with a His-to-ventricle interval exceeding 55 ms, as documented by electrophysiologic study. Eight (9.6%) patients died: 2 from noncardiac and 1 from unknown causes, 1 from heart failure, and 4 from sudden death closely related to documented ventricular tachycardia. The incidence and seriousness of arrhythmic and conduction disturbances correlated with the severity of the muscular involvement. Nevertheless, cardiac and muscular disease did not show a linear progression. Cardiac involvement generally worsened more rapidly than did skeletal muscle disease. [ABSTRACT FROM AUTHOR]

Published
2000
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38. Morphologic left ventricular patterns and prevalence of high-grade ventricular arrhythmias in the normotensive and hypertensive elderly.

Author

Mammarella, Antonio, Paradiso, Michele, Basili, Stefania, Matteis, Antonio, Cardarello, Cristiano, Franco, Manuela, Donnarumma, Lucia, Labbadia, Giancarlo, Paoletti, Vincenzo, Mammarella, A, Paradiso, M, Basili, S, De Matteis, A, Cardarello, C M, Di Franco, M, Donnarumma, L, Labbadia, G, and Paoletti, V

Abstract

In the elderly, systemic hypertension is the main risk factor for cardiovascular diseases. Left ventricular hypertrophy, the most common adaptation to chronic pressure overload, has been recognized as an independent risk factor for an increased incidence of sudden death and arrhythmic disturbances. This study compared the prevalence of serious ventricular arrhythmias in elderly individuals with uncomplicated hypertension and in normotensive age-matched controls, using left ventricular mass index (LVMI) to differentiate patterns of anatomic adaptation to systolic, diastolic, or systolic-diastolic hypertension. The study enrolled 378 consecutive untreated elderly subjects (> or = 65 years of age), without clinical evidence of heart failure; 203 were hypertensive and 175 were normotensive. Each participant underwent standard 12-lead electrocardiography, M-mode and B-mode echocardiography, and 24-hour ambulatory electrocardiographic monitoring. Serious, statistically significant arrhythmias (Lown classes > or = 3) were present in 6.8% of normal subjects versus 17.1% of individuals with systolic, 31.5% of those with diastolic, and 20.4% of participants with systolic-diastolic hypertension. Arrhythmias did not differ in terms of left ventricular morphologic patterns or LVMI or between subgroups of hypertensive patients. Our data support the hypothesis that the pathogenesis of arrhythmias is related not to the electrophysiologic derangement of hypertrophied muscle but, rather, to the effects of hypertension on the cardiac structure. Cardiac fibrosis, one of the deleterious events accompanying hypertension, may be the main substrate for ventricular arrhythmias. [ABSTRACT FROM AUTHOR]

Published
2000
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41. Characterization of spatial variability structure in three separate field trials on pesticide dissipation

Author

Trevisan, M., Conte, E., Imbroglini, G., Donnarumma, L., Marini, M., Vischetti, C., Businelli, M., Capri, E., and Del Re, A. A. M.

Subjects
PESTICIDES, STATISTICS
Abstract

Experiments were carried out on three Italian farms to assess the degree of spatial variation of pesticide field concentration during treatment and during dissipation trials. Test pesticides were chloridazon and metamitron (both sugar-beet herbicides) applied as a tank mix. The classical statistical technique and geostatistics were used to summarize and evaluate variable spatial data. The results show that theactual values of pesticide concentration for application rate and initial concentration in all three areas are lower than expected, thus indicating that under field conditions only a part of the pesticide reaches the soil during the distribution. The actual values for both herbicides in all three areas expressed as percentage of expected values ranged from 44.1% to 64.2% for application rate and from 40.5% to 99.5% for initial concentration. The coefficient of variation was similar for both pesticides and ranged from 23.8 to 74.1 for applicationrate, 24.1 and 58.8 for initial concentration and 11.1 and 110.0 fordissipation half-lives. The high variability in application rate andinitial concentration could be ascribed to an uneven herbicide distribution, and in dissipation studies to variation in half-lives for the rate of herbicide loss from soil in different parts of the field. Geostatistic analysis indicated little spatial correlation, probably because the sampling sites were widely spaced on the field. In all cases, the data were not sufficient to estimate the range of influence, probably because of the size of the experimental fields and the sampling strategy. [ABSTRACT FROM AUTHOR]

Published
1997

42. Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network

Author

Maria Grazia Rumi, Teresa Santantonio, Vincenza Calvaruso, D.C. Amoruso, Giovanni Raimondo, Salvatore Petta, Maria Cristina Pasetto, Romina Corsini, Alfredo Di Leo, Anna Linda Zignego, Barbara Coco, Francesco Paolo Russo, Giovanni Battista Gaeta, Maurizia Rossana Brunetto, Giuseppina Brancaccio, Veronica Bernabucci, Alberto Zanetto, Filomena Morisco, Mario Masarone, Pietro Andreone, Pierluigi Blanc, D. Ieluzzi, Salvatore Madonia, Adele Giammario, Marzia Margotti, Edoardo G. Giannini, M. Cannizzaro, Emanuela Zappulo, Gloria Taliani, Monica Monti, Roberto Filomia, Marco Massari, Guglielmo Borgia, Andrea Iannone, Massimo Siciliano, Erica Villa, Marcello Persico, Stefano Vella, Stefano Rosato, Maria Giovanna Quaranta, L. E. Weimer, Carmine Coppola, Liliana Chemello, Loreta A. Kondili, Barbara Del Pin, Loredana Falzano, Luchino Chessa, L. Donnarumma, Luisa Cavalletto, Elisa Biliotti, Antonio Gasbarrini, Kondili, Loreta A., Gaeta, Giovanni Battista, Brunetto, Maurizia Rossana, Di Leo, Alfredo, Iannone, Andrea, Santantonio, Teresa Antonia, Giammario, Adele, Raimondo, Giovanni, Filomia, Roberto, Coppola, Carmine, Amoruso, Daniela Caterina, Blanc, Pierluigi, Del Pin, Barbara, Chemello, Liliana, Cavalletto, Luisa, Morisco, Filomena, Donnarumma, Laura, Rumi, Maria Grazia, Gasbarrini, Antonio, Siciliano, Massimo, Massari, Marco, Corsini, Romina, Coco, Barbara, Madonia, Salvatore, Cannizzaro, Marco, Zignego, Anna Linda, Monti, Monica, Russo, Francesco Paolo, Zanetto, Alberto, Persico, Marcello, Masarone, Mario, Villa, Erica, Bernabucci, Veronica, Taliani, Gloria, Biliotti, Elisa, Chessa, Luchino, Pasetto, Maria Cristina, Andreone, Pietro, Margotti, Marzia, Brancaccio, Giuseppina, Ieluzzi, Donatella, Borgia, Guglielmo, Zappulo, Emanuela, Calvaruso, Vincenza, Petta, Salvatore, Falzano, Loredana, Quaranta, Maria Giovanna, Weimer, Liliana Elena, Rosato, Stefano, Vella, Stefano, Giannini, Edoardo Giovanni, Kondili LA, Gaeta GB, Brunetto MR, Di Leo A, Iannone A, Santantonio TA, Giammario A, Raimondo G, Filomia R, Coppola C, Amoruso DC, Blanc P, Del Pin B, Chemello L, Cavalletto L, Morisco F, Donnarumma L, Rumi MG, Gasbarrini A, Siciliano M, Massari M, Corsini R, Coco B, Madonia S, Cannizzaro M, Zignego AL, Monti M, Russo FP, Zanetto A, Persico M, Masarone M, Villa E, Bernabucci V, Taliani G, Biliotti E, Chessa L, Pasetto MC, Andreone P, Margotti M, Brancaccio G, Ieluzzi D, Borgia G, Zappulo E, Calvaruso V, Petta S, Falzano L, Quaranta MG, Weimer LE, Rosato S, Vella S, Giannini EG., Kondili, L., Gaeta, G., Brunetto, M., Di Leo, A., Iannone, A., Santantonio, T., Giammario, A., Raimondo, G., Filomia, R., Coppola, C., Amoruso, D., Blanc, P., Del Pin, B., Chemello, L., Cavalletto, L., Morisco, F., Donnarumma, L., Rumi, M., Gasbarrini, A., Siciliano, M., Massari, M., Corsini, R., Coco, B., Madonia, S., Cannizzaro, M., Zignego, A., Monti, M., Russo, F., Zanetto, A., Persico, M., Masarone, M., Villa, E., Bernabucci, V., Taliani, G., Biliotti, E., Chessa, L., Pasetto, M., Andreone, P., Margotti, M., Brancaccio, G., Ieluzzi, D., Borgia, G., Zappulo, E., Calvaruso, V., Petta, S., Falzano, L., Quaranta, M., Weimer, L., Rosato, S., Vella, S., and Giannini, E.

Subjects
Simeprevir, Male, Genetics and Molecular Biology (all), Hepacivirus, Pediatrics, Gastroenterology, Biochemistry, 0302 clinical medicine, Animal Cells, 80 and over, Bile, Medicine, Public and Occupational Health, Prospective Studies, lcsh:Science, Aged, 80 and over, Adult, Aged, Antiviral Agents, Drug Therapy, Combination, Female, Hepatitis C, Humans, Incidence, Liver Diseases, Middle Aged, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Liver Disease, Child Health, Blood, Cirrhosis, Physical Sciences, Regression Analysis, 030211 gastroenterology & hepatology, Cellular Types, Statistics (Mathematics), Human, medicine.medical_specialty, Gastroenterology and Hepatology, Microbiology, 03 medical and health sciences, Drug Therapy, Statistical Methods, Blood Cells, Flaviviruses, lcsh:R, Organisms, Biology and Life Sciences, medicine.disease, Regimen, Prospective Studie, 030104 developmental biology, chemistry, lcsh:Q, Mathematics, Developmental Biology, RNA viruses, 0301 basic medicine, DAA, HCV, resistance, Sofosbuvir, Physiology, lcsh:Medicine, Liver disease, chemistry.chemical_compound, Mathematical and Statistical Techniques, Medicine and Health Sciences, Pathology and laboratory medicine, Multidisciplinary, Hepatitis C virus, Medical microbiology, Body Fluids, Viruses, Combination, Anatomy, Pathogens, Research Article, medicine.drug, Platelets, Ledipasvir, Daclatasvir, Settore MED/12 - GASTROENTEROLOGIA, HCV, liver diseases, Cirrhosis, DAA failure, Research and Analysis Methods, Internal medicine, Antiviral Agent, business.industry, Viral pathogens, Bilirubin, Cell Biology, Fibrosis, Hepatitis viruses, Microbial pathogens, Surgery, Liver function, business
Abstract

Background: Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure. Aim: To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage. Methods: Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers. Results: Among 3,830 patients with advanced fibrosis (F3) or cirrhosis, 139 (3.6%) failed to achieve SVR. Genotype 3, bilirubin levels >1.5mg/dl, platelet count

Published
2017

43. Unmanned aerial vehicle technology to assess the state of threatened biogenic formations: The vermetid reefs of mediterranean intertidal rocky coasts

Author

Luigia Donnarumma, Renato Chemello, Giovanni Fulvio Russo, Roberto Sandulli, Antonio D'Argenio, Donnarumma L., D'Argenio A., Sandulli R., Russo G.F., and Chemello R.

Subjects
Settore BIO/07 - Ecologia, geography, RPAS, geography.geographical_feature_category, Dendropoma cristatum, Hydrodynamic regime, Mediterranean sea, Remote sensing, RPAS, UAV, Vermetid molluscs, UAV, Vermetid molluscs, Intertidal zone, Aquatic Science, Remote sensing, Dendropoma cristatum, Oceanography, Ecosystem engineer, Structural complexity, Hydrodynamic regime, Rocky shore, Mediterranean sea, Spatial ecology, Littoral zone, Remote sensing, RPAS, UAV, Vermetid molluscs, Dendropoma cristatum, Hydrodynamic regime, Mediterranean sea, Reef, Geology
Abstract

Vermetid bioconstructions are biogenic formations, built by sessile gastropod molluscs belonging to the family Vermetidae worldwide distributed, occurring in the intertidal and upper subtidal in the rocky shores. In the Mediterranean basin, they occur in complex and tridimensional structures that enhance the local biodiversity, allowing to qualify the structuring species as ecosystem engineers. Due to their ecological relevance and considerable extension along the coasts, we assessed their structural complexity using unmanned aerial vehicle (UAV) technology, as tool of littoral cartography analysis of these bioconstructions, and plaster hemispheres dissolution as a descriptor index of the water movement on them. We adopted an UAV to produce a very high spatial resolution map along 830m of rocky coast where these vermetid gastropods occur. Through an orthophoto with a GSD (Ground Sample Distance) of 1 cm, different complexity values of indentation degree (or roughness profiles) of the reef boundaries were detected, corroborating literature data carried out with traditional measurement techniques (e.g., tape measure). Our results indicate that the most complex zone of reef is the outer edge, facing the open sea, with a decreasing trend toward the inner edge. Concerning the experimental approach conducted using plaster hemispheres placed along the platform, it reveals that water movement is a structuring factor of the vermetid reef complexity along the rocky coast. Overall, the application of UAV technique allows an appropriate approach to analyze different zones of the vermetid reefs with a high-accuracy on a large spatial scale, greatly reducing sampling effort, and generating important implications for future monitoring and conservation programs.

Published
2021

44. Population ecology of Jujubinus striatus and Jujubinus exasperatus (Gastropoda: Trochidae) in a Posidonia oceanica seagrass bed

Author

R. Bruno, Giovanni Fulvio Russo, Luigia Donnarumma, Antonio Terlizzi, Donnarumma, L., Bruno, R., Terlizzi, A., and Russo, G. F.

Subjects
0106 biological sciences, 010607 zoology, Molluscs, Posidonia oceanica, Jujubinus, lifespan, growth rate, Jujubinu, 01 natural sciences, Abundance (ecology), Gastropoda, lcsh:Zoology, lcsh:QL1-991, Semelparity and iteroparity, biology, Ecology, 010604 marine biology & hydrobiology, Trochidae, Population ecology, biology.organism_classification, Seagrass, Jujubinus striatus, Animal Science and Zoology, Mollusc
Abstract

The population structure of Jujubinus striatus and Jujubinus exasperatus (Trochidae), common gastropod grazers of Posidonia oceanica leaves, was investigated in the seagrass bed off Lacco Ameno of Ischia (Gulf of Naples). Sampling was performed monthly, from July 1981 to June 1982, at five stations along a depth gradient (1, 3, 10, 15 and 25 m), using a hand-towed net. Throughout the study period, both populations were characterised by seasonal fluctuations in abundance, with a total of 550 individuals counted and measured. The two populations analysed showed different distributional trends along the depth gradient. Jujubinus striatus settled and occurred mainly at shallower stands (1–3 m depth), while J. exasperatus was found deeper (10–15 m). Both species are semelparous. Juveniles and small individuals (shell height < 4 mm) were mainly found during the late winter and early spring months. The survivorship curves of both Jujubinus species showed a very low mortality rate in the first few months after settlement. Demographic analysis suggests an indeterminate growth rate after sexual maturity, with a lifespan of about 22 months for J. striatus and 17 months for J. exasperatus. For both species the growth rate is fast during the first couple of months after settlement. The findings of this study, compared with earlier work, reveal a certain number of shared traits in the life cycle of the most common gastropod species living on the leaves of P. oceanica seagrass: semelparous reproduction, spring settlement, fast early growth and short lifespan (2 years maximum).

Published
2018

45. Population ecology of Gibbula umbilicaris and Gibbula ardens(Gastropoda: Trochidae) in a Posidonia oceanicaseagrass bed

Author

Luigia Donnarumma, R. Bruno, Antonio Terlizzi, Giovanni Fulvio Russo, Donnarumma, L., Bruno, R., Terlizzi, Antonio, and Russo, G. F.

Subjects
growth rate, lifespan, Mediterranean Sea, Molluscs, recruitment, Animal Science and Zoology, 0106 biological sciences, biology, Molluscs, lifespan, Mediterranean Sea, growth rate, recruitment, Ecology, 010604 marine biology & hydrobiology, Trochidae, Population ecology, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Gibbula, Seagrass, Mediterranean sea, Common species, Posidonia oceanica, Gastropoda, Mollusc
Abstract

Population structures of the gastropods Gibbula umbilicaris and Gibbula ardens (Trochidae), the two most common species of the genus Gibbula living in shallow beds of the Mediterranean seagrass Posidonia oceanica, were investigated in the seagrass bed off Lacco Ameno of Ischia (Gulf of Naples), at six stations along a depth gradient (1, 3, 5, 10, 15 and 25m). Sampling was performed on a monthly basis for 1 year. A total of 853 individuals were counted and measured. The two gastropod populations analysed show a rather similar distributional trend in all seasons and depths. Recruitment occurred at the shallowest stations (1-3m depth), where the populations were characterised by higher values of abundance and biomass, confirming that G. umbilicaris and G. ardens are typical species of the shallow community of P. oceanica seagrass beds. Juveniles were exclusively found in 1 month of the whole year: G. umbilicaris in April, G. ardens in July. The survivorship curves of both Gibbula species, derived from the size-frequency distribution of shells, showed a very low mortality rate in the first months after settlement. Demographic analysis of G. umbilicaris suggests a rather slow growth rate and a polymorphic maturation strategy with a lifespan of 1 year for most individuals, but lifespan may also reach about 2 years in a few specimens. Gibbula ardens has a lifespan of about 1 year and a fast growth rate, especially during the first couple of months after settlement. Therefore, on the basis of lifespan and recruitment time, both species seem to be semelparous.

Published
2015

46. P729 HCV GENOTYPE 1A AND 1B: SIMILARITIES AND DIFFERENCES IN CLINICAL FEATURES, THERAPEUTIC OUTCOME AND PREDICTORS OF RESPONSE.

Author

Morisco, F., Di Marco, V., Granata, R., Camera, S., Ippolito, A., Margaglione, M., Fattovich, G., Smedile, A., Clery, E., Ferraiuoli, C., Guarino, M., Donnarumma, L., Valvano, M.R., Milella, M., Felder, M.M., Gaeta, G.B., Gatti, P., Tundo, P., Barone, M., and Cozzolongo, R.

Subjects
*HEPATITIS C treatment, *HEPATITIS C, *GENOTYPES, *HEALTH outcome assessment, *FIBROSIS, *CHILDREN'S health, *PATIENTS, *DIAGNOSIS
Published
2014
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48. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study.

Author

Tursi A, Mocci G, Scaldaferri F, Napolitano D, Maresca R, Pugliese D, Semprucci G, Savarino E, Cuomo A, Donnarumma L, Bodini G, Pasta A, Maconi G, Cataletti G, Pranzo G, Rodinò S, Sebkova L, Costa F, Ferronato A, Gaiani F, Marzo M, Luppino I, Fabiano G, Paese P, Elisei W, Monterubbianesi R, Faggiani R, Grossi L, Serio M, Scarcelli A, Lorenzetti R, Allegretta L, Chiri S, Grasso G, Antonelli E, Bassotti G, Spagnuolo R, Luzza F, Fanigliulo L, Rocco G, Sacchi C, Zampaletta C, Rocchi C, Bolognini L, Bendia E, Bianco MA, Capone P, Meucci C, Colucci R, Tonti P, Neve V, Della Valle N, Felice C, Pica R, Cocco A, Forti G, Onidi FM, Usai Satta P, Checchin D, Gravina AG, Pellegrino R, Picchio M, and Papa A

Subjects
Humans, Middle Aged, Ustekinumab adverse effects, Retrospective Studies, Remission Induction, Cohort Studies, Adrenal Cortex Hormones therapeutic use, Leukocyte L1 Antigen Complex therapeutic use, Treatment Outcome, Colitis, Ulcerative diagnosis, Colitis, Ulcerative drug therapy
Abstract

Background: Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients with UC in a real-world setting., Research Design and Methods: This is a multicenter, retrospective, observational cohort study. The primary endpoints were the clinical remission rate (partial Mayo score, PMS, ≤1) and the safety of UST. Other endpoints were corticosteroid-free remission (CSFR) rate, clinical response rate (PMS reduction of at least 2 points), and fecal calprotectin (FC) reduction at week 24., Results: We included 256 consecutive patients with UC (M/F 139/117, median age 52). The clinical remission and clinical response rates at eight weeks were 18.7% (44/235) and 53.2% (125/235), respectively, and 27.6% (42/152) and 61.8% (94/152) at 24 weeks, respectively. At 24 weeks, CSFR was 20.3% (31/152), and FC significantly dropped at week 12 ( p  = 0.0004) and 24 ( p  = 0.038). At eight weeks, patients naïve or with one previous biologic treatment showed higher remission ( p  = 0.002) and clinical >response rates ( p  = 0.018) than patients previously treated with ≥ 2. Adverse events occurred in six patients (2.3%), whereas four patients (1.6%) underwent colectomy., Conclusion: This real-world study shows that UST effectively and safely treats patients with UC.

Published
2024
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49. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn's disease: results from an Italian multicenter study.

Author

Mocci G, Tursi A, Maconi G, Cataletti G, Mantia B, Serio M, Scarcelli A, Pagnini C, Graziani MG, Di Paolo MC, Pranzo G, Luppino I, Paese P, Elisei W, Monterubbianesi R, Faggiani R, Ferronato A, Perini B, Savarino E, Onidi FM, Binaghi L, Usai Satta P, Schiavoni E, Napolitano D, Scaldaferri F, Pugliese D, Pica R, Cocco A, Zippi M, Rodino S, Sebkova L, Rocco G, Sacchi C, Zampaletta C, Gaiani F, De Angelis G, Kayali S, Fanigliulo L, Lorenzetti R, Allegretta L, Scorza S, Cuomo A, Donnarumma L, Della Valle N, Sacco R, Forti G, Antonelli E, Bassotti G, Iannelli C, Luzza F, Aragona G, Perazzo P, Lauria A, Piergallini S, Colucci R, Bianco MA, Meucci C, Giorgetti G, Clemente V, Fiorella S, Penna A, De Medici A, Picchio M, and Papa A

Subjects
Humans, C-Reactive Protein analysis, Remission Induction, Italy, Gastrointestinal Agents therapeutic use, Treatment Outcome, Retrospective Studies, Crohn Disease drug therapy, Colitis, Ulcerative drug therapy, Inflammatory Bowel Diseases drug therapy
Abstract

Background: Vedolizumab (VDZ) can be used to treat refractory ulcerative colitis (UC) and Crohn's disease (CD). We assessed whether there are differences in treating UC vs CD with VDZ., Research Design and Methods: Mayo score in UC and the Harvey-Bradshaw Index (HBI) in CD scored the clinical activity. Achievement and maintenance of clinical remission during the follow-up, and safety were the primary endpoints., Results: 729 patients (475 with UC and 254 with CD), median follow-up of 18 (IQR 6-36) months, were enrolled. Clinical remission at the 6 th month of treatment was achieved in 488 (66.9%) patients (74.4% in CD vs 62.9% in UC, p<0.002) while, during the follow-up, no difference was found (81.5% in the UC group and 81.5% pts in the CD group; p=0.537). The clinical remission at the 6 th month of treatment (p=0.001) and being naïve to biologics (p<0.0001) were significantly associated with prolonged clinical remission. The clinical response was significantly higher in UC (90.1%) vs CD (84.3%) (p=0.023), and surgery occurred more frequently in CD (1.9% in UC vs 5.1% in CD, p=0.016)., Conclusion: We found differences when using VDZ in UC vs CD in real life. These parameters can help the physician predict this drug's longterm efficacy.

Published
2023
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50. Comparison of Performances of Adalimumab Biosimilars SB5, ABP501, GP2017, and MSB11022 in Treating Patients with Inflammatory Bowel Diseases: A Real-Life, Multicenter, Observational Study.

Author

Tursi A, Mocci G, Allegretta L, Aragona G, Bianco MA, Colucci R, Cuomo A, Della Valle N, Ferronato A, Forti G, Gaiani F, Giorgetti G, Graziani MG, Lofano K, Lorenzetti R, Larussa T, Penna A, Pica R, Pranzo G, Rodino' S, Scarcelli A, Zampaletta C, Bassotti G, Cazzato AI, Chiri S, Clemente V, Cocco A, De' Angelis G, Donnarumma L, Faggiani R, Graziosi C, Le Grazie M, Luzza F, Meucci C, Monterubbianesi R, Pagnini C, Perazzo P, Picchio M, Sacco R, Sebkova L, Serio M, Napolitano D, Pugliese D, Scaldaferri F, Schiavoni E, Turchini L, Armuzzi A, Elisei W, Maconi G, and Papa A

Subjects
Humans, Adalimumab therapeutic use, Retrospective Studies, Treatment Outcome, Biosimilar Pharmaceuticals therapeutic use, Inflammatory Bowel Diseases drug therapy, Colitis, Ulcerative drug therapy, Crohn Disease drug therapy
Abstract

Background: Adalimumab (ADA) biosimilars have entered the therapeutic armamentarium of inflammatory bowel disease (IBD), allowing for the treatment of a greater number of patients for their reduced cost than the originator. However, comparative data on the efficacy and safety of the various ADA biosimilars remains scarce.We compare the efficacy and safety of ADA biosimilars SB5, ABP501, GP2017, and MSB11022 in treating IBD outpatients in a real-life Italian setting., Methods: A retrospective analysis was performed on consecutive IBD outpatients with complete clinical, laboratory, and endoscopic data. Clinical activity was measured using the Mayo score in ulcerative colitis (UC) and the Harvey-Bradshaw Index in Crohn's disease (CD). The primary endpoints were the following: (1) induction of remission in patients new to biologics and patients new to ADA but previously exposed to other anti-tumor necrosis factor agents or other biologics; (2) maintenance of remission in patients switched from the ADA originator to an ADA biosimilar; and (3) safety of various biosimilars., Results: A total of 533 patients were enrolled according to the inclusion criteria: 162 patients with UC and 371 patients with CD. Clinical remission was obtained in 79.6% of patients new to biologics and 59.2% of patients new to ADA but not to other biologics; clinical remission was maintained in 81.0% of patients switched from the originator, and adverse events were recorded in 6.7% of patients. There was no significant difference between the 4 ADA biosimilars for each predetermined endpoint., Conclusions: Adalimumab biosimilars are effective and safe in IBD treatment, both in new patients and in patients switched from the ADA originator. No difference in efficacy and safety was found between ADA biosimilars., (© The Author(s) 2022. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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