12 results on '"Domínguez Ortega G"'
Search Results
2. Efficacy of therapy for paediatric eosinophilic esophagitis in real-life practice: results from the Spanish Prospective Multicenter Registry RENESE.
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Gutiérrez-Junquera, C., Fernández-Fernández, S., Domínguez-Ortega, G., Vila, V., Garcia-Puig, R., Orden, E. La, Reyes, A. I., Barrio, J., Medina, E., Leis, R., García-Romero, R., Fernández de Valderrama, A., Vecino, R., Donado, P., Colomé, G., Beltrán, M. Alvarez, Caamaño, B. Fernandez, Eizaguirre, F. J., Balmaseda, E., and Barros, P.
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- 2022
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3. Extraintestinal manifestations in children with gastrointestinal food allergy.
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Domínguez-Ortega, G, Borrelli, O, Meyer, R, Dziubak, R, De Koker, C, Godwin, H, Fleming, C, Thapar, N, Elawad, M, Kiparissi, F, Fox, A T, and Shah, N
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- 2014
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4. Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis: Predictive Factors and Long-Term Step-Down Efficacy.
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Gutiérrez-Junquera C, Fernández-Fernández S, Domínguez-Ortega G, Vila Miravet V, García-Puig R, La Orden-Izquierdo E, Peña Quintana L, Barrio Torres J, Medina Benítez E, Leis R, García-Romero R, Fernández de Valderrama A, Vecino López R, and Donado Palencia P
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- Humans, Proton Pump Inhibitors therapeutic use, Prospective Studies, Cross-Sectional Studies, Eosinophilic Esophagitis pathology
- Abstract
Objectives: To assess the short- and long-term efficacy of proton pump inhibitor (PPI) therapy for pediatric eosinophilic esophagitis (EoE) in real-world practice with a step-down strategy, and to evaluate factors predictive of PPI responsiveness., Methods: We collected data regarding the efficacy of PPIs during this cross-sectional analysis of the prospective nationwide RENESE registry. Children with EoE treated with PPI monotherapy were included. Histological remission was defined as a peak eosinophilic count of <15 eosinophils (eos)/high-power field (hpf). Factors associated with PPI responsiveness were identified using multivariate logistic regression analysis., Results: After induction therapy, histological and clinico-histological remission were observed in 51.4% (n = 346) and 46.5% of children, respectively. Normal endoscopic appearance of the esophagus was associated with a higher possibility [odds ratio (OR), 9.20; 95% confidence interval (CI), 2.10-40.16], and fibrostenotic phenotype was associated with a lower possibility (OR, 0.36; 95% CI, 0.18-0.74) of histological remission. Long-term therapy with a step-down strategy effectively maintained histological remission in 68.5% and 85.3% of children at 7 months (n = 108) and 16 months (n = 34), respectively. Complete initial histological remission (≤5 eos/hpf) was associated with a higher possibility of sustained histological remission (OR, 5.08; 95% CI, 1.75-14.68). Adverse events were infrequent and mild., Conclusions: We confirmed the efficacy of PPIs for a large cohort of children with EoE with sustained histological remission using a step-down strategy. Children with fibrostenotic phenotypes are less likely to respond to induction therapy. Furthermore, patients with complete initial histological remission are more likely to experience long-term histological remission., Competing Interests: The authors report no conflicts of interest., (Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
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- 2023
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5. Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN.
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Oliva S, Dias JA, Rea F, Malamisura M, Espinheira MC, Papadopoulou A, Koutri E, Rossetti D, Orel R, Homan M, Bauraind O, Auth MK, Junquera CG, Vande Velde S, Kori M, Huysentruyt K, Urbonas V, Roma E, Fernández SF, Domínguez-Ortega G, Zifman E, Kafritsa P, Miele E, and Zevit N
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- Adolescent, Child, Child, Preschool, Delayed Diagnosis, Endoscopy, Gastrointestinal, Enteritis, Eosinophilia, Female, Gastritis, Humans, Male, Proton Pump Inhibitors therapeutic use, Registries, Deglutition Disorders drug therapy, Deglutition Disorders etiology, Eosinophilic Esophagitis complications, Eosinophilic Esophagitis diagnosis, Eosinophilic Esophagitis epidemiology, Food Hypersensitivity
- Abstract
Objectives: Few pediatric data on phenotypic aspects of eosinophilic esophagitis (EoE) are available. The pEEr registry was developed to prospectively characterize children with EoE from Europe and Israel., Methods: pEEr is an ongoing prospective registry enrolling children with esophageal eosinophilia (≥15 eos/HPF). Anonymized data were collected from 19 pediatric centers. Data regarding demographics, clinical manifestations, endoscopy, histology, and therapies were collected., Results: A total of 582 subjects (61% male) were analyzed. The median age at diagnosis was 10.5 years [interquartile range (IQR): 5.7-17.7], whereas the age at symptom onset was 9.2 years (IQR: 4.3-16.4), resulting in a median diagnostic delay of 1.2 years (IQR: 0.7-2.3). The diagnostic delay was longer below age <6 years. Shorter diagnostic delays were associated with the presence of food allergy or a family history for EoE. Symptoms varied by age with dysphagia and food impaction more common in adolescents, while vomiting and failure to thrive more common in younger children ( P < 0.001). Among endoscopic findings, esophageal rings were more common in adolescents, whereas exudates were more frequent in younger children( P < 0.001). Patients who responded to proton pump inhibitors (PPIs) were more likely to be older, males, and less often presented severe endoscopic findings. Patients unresponsive to PPIs received topical steroids (40%), elimination diet (41%), or a combined therapy (19%)., Conclusions: EoE findings vary according to age in pediatric EoE. Young children are commonly characterized by non-specific symptoms, atopic dermatitis, food allergy, and inflammatory endoscopic lesions. Adolescents usually have dysphagia or food impaction, fibrostenotic lesions, and a better PPI response., Competing Interests: Noam Zevit: consultation fees – Dr Falk Pharma, Adare Pharmaceuticals; speaker fees – Rafa inc and Sanofi. Salvatore Oliva: consultation fees – Medtronic, Ocean Farma; speaker fees – Medtronic. Marcus Karl-Heinz Auth – consultation fees: Dr Falk Pharma; educational grants: Nutricia, Mead Johnson. Alexandra Papadopoulou: research grants from Abbvie, United Pharmaceuticals, Dr Falk Pharma GmbH, Takeda, AstraZeneca; speaker or consultation fees from Adare Pharmaceuticals, Dr Falk Pharma GmbH, Specialty Therapeutics, Uni-Pharma Pharmaceuticals Laboratories S.A., Cross Pharmaceuticals, Petsiavas, Nestle, Touch Independent Medical Education, and Sanofi-Aventis. The remaining authors report no conflicts of interest., (Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
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- 2022
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6. Faecal calprotectin in children with multisystem inflammatory syndrome: A pilot case-control study.
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Gonzalez Jimenez D, Velasco Rodríguez-Belvís M, Domínguez Ortega G, Segarra Cantón O, and Diaz Martin JJ
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- Adolescent, Biomarkers, Case-Control Studies, Child, Feces, Humans, Pilot Projects, COVID-19, Leukocyte L1 Antigen Complex, Systemic Inflammatory Response Syndrome
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- 2021
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7. Systemic steroids have a role in treating esophageal strictures in pediatric eosinophilic esophagitis.
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Hoofien A, Rea F, Espinheira MDC, Amil Dias J, Romano C, Oliva S, Auth MK, Zangen T, Kalach N, Domínguez-Ortega G, De Angelis P, and Zevit N
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- Administration, Oral, Adolescent, Child, Child, Preschool, Eosinophilic Esophagitis drug therapy, Esophageal Stenosis etiology, Esophagoscopy, Female, Humans, Male, Methylprednisolone adverse effects, Prednisolone adverse effects, Retrospective Studies, Steroids adverse effects, Eosinophilic Esophagitis complications, Esophageal Stenosis drug therapy, Methylprednisolone administration & dosage, Prednisolone administration & dosage, Steroids administration & dosage
- Abstract
Background: The role of systemic steroids in the treatment of esophageal strictures in children with Eosinophilic Esophagitis (EoE) is poorly defined., Aims: To describe a cohort of children with EoE-associated esophageal strictures responding to systemic steroids., Methods: Retrospective review of medical records of children with EoE and moderate (<9 mm) to severe (<6 mm) strictures, who responded clinically and endoscopically to systemic steroids., Results: Twenty children (median age 10.6 ± 4.2 years; 17 males) from nine centers in six countries were included in the analysis; 16 had moderate and four, severe strictures; 18 had dysphagia or bolus impaction; median diagnostic delay was 8 months (IQR 3.5-35). Eighteen patients received oral systemic steroids (mean dose 1.4 mg/kg/day) for a median of 4 weeks, while two initially received IV steroids. All patients showed clinical improvement and 15/20 became asymptomatic. Stricture resolution at endoscopy was found in 19/20, while histological resolution of EoE (<15 eos/hpf) in 13/20. Only minor side effects were reported: hyperphagia (10/20); weight gain (5/20); hyperactivity (2/20) and acne (1/20). Esophageal dilation was required in 3/20 patients during a median follow-up of 48.5 months (IQR 26.7-73.2)., Conclusion: Children with EoE and esophageal strictures, may benefit from the use of a short course of systemic steroids, avoiding mechanical dilation., Competing Interests: Declaration of Competing Interest Manuscript title: Systemic Steroids Have a Role in Treating Esophageal Strictures in Pediatric Eosinophilic Esophagitis List of coauthors: Assaf Hoofien, Francesca Rea, Maria do Céu Espinheira, Jorge Amil Dias, Claudio Romano, Salvatore Oliva, Marcus Karl-Heinz Auth, Tsili Zangen, Nicolas Kalach, Gloria Domínguez-Ortega, Paola De Angelis Noam Zevit. This study was supported by an unconditional gift to the research fund of Dr. Noam Zevit at Schneider Medical Center by Mrs. Martha White, in loving memory of Dr. Seymor White and Dr. Judah White. Dr. Noam Zevit reports receiving consultation fees from Adare Pharmaceuticals and Dr. Falk Pharma ltd. All other authors report no relevant conflicts of interest., (Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
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- 2021
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8. COVID-19 Gastrointestinal Manifestations Are Independent Predictors of PICU Admission in Hospitalized Pediatric Patients.
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Gonzalez Jimenez D, Velasco Rodríguez-Belvís M, Ferrer Gonzalez P, Domínguez Ortega G, Segarra O, Medina Benitez E, Garcia Tirado D, Garcia Romero R, Vecino López R, Crehuá-Gaudiza E, Queralt M, Palomino Pérez LM, and Diaz Martin JJ
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- COVID-19 virology, Child, Child, Preschool, Comorbidity, Female, Humans, Infant, Intensive Care Units, Pediatric, Male, Spain epidemiology, COVID-19 complications, COVID-19 epidemiology, Gastrointestinal Diseases epidemiology, Gastrointestinal Diseases etiology, Intensive Care, Neonatal methods, Intensive Care, Neonatal statistics & numerical data, Patient Admission
- Abstract
Multicenter study conducted in 15 hospitals including 101 COVID-19 pediatric inpatients aiming to describe associated gastrointestinal (GI) manifestations. GI symptoms were present in 57% and were the first manifestation in 14%. Adjusted by confounding factors, those with GI symptoms had higher risk of pediatric intensive care unit admission. GI symptoms are predictive of severity in COVID-19 children admitted to hospitals.
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- 2020
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9. Normal fecal calprotectin levels in healthy children are higher than in adults and decrease with age.
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Velasco Rodríguez-Belvís M, Viada Bris JF, Plata Fernández C, García-Salido A, Asensio Antón J, Domínguez Ortega G, and Muñoz Codoceo RA
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Background/objectives: The paediatric reference range of fecal calprotectin (FC) has not been decisively established and previous studies show a wide within-age variability, suggesting that other factors like anthropometric data or type of feeding can influence FC. Our aims were to establish the normal levels of FC in healthy children grouped by age and analyze whether sex, gestational age, birth weight, type of delivery, type of feeding, or anthropometric data influence FC values., Methods: This multicentre, cross-sectional, and observational study enrolled healthy donors under 18 years of age who attended their Primary Health Care Centre for their routine Healthy Child Program visits. The exclusion criteria were: (i) immunodeficiency, (ii) autoimmune or (iii) gastrointestinal disease; (iv) medication usage; (v) gastrointestinal symptoms; or (vi) positive finding in the microbiological study., Results: We enrolled 395 subjects, mean age was 4.2 years (range 3 days to 16.9 years), and 204 were male. The median FC was 77.0 mcg/g (interquartile range 246). A negative correlation between age and FC was observed (Spearman's rho = -0.603, P<0.01), and none of the other factors analyzed were found to influence FC levels., Conclusions: Normal FC values in healthy children (particularly in infants) are higher than those considered to be altered in adults and show a negative correlation with age. It is necessary to reconsider the upper limits of FC levels for paediatric patients according to age, with further studies required to determine other factors that influence FC during infancy., (© The Author(s) 2019. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2020
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10. Sustained Remission of Eosinophilic Esophagitis Following Discontinuation of Dietary Elimination in Children.
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Hoofien A, Papadopoulou A, Gutiérrez-Junquera C, Martínez Gómez MJ, Domínguez-Ortega G, Oudshoorn J, Roma E, Dias JA, Oliva S, Marderfeld L, and Zevit N
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- Child, Eosinophilic Esophagitis etiology, Food Hypersensitivity complications, Humans, Remission Induction, Allergens adverse effects, Eosinophilic Esophagitis diet therapy, Food adverse effects, Food Hypersensitivity diet therapy, Withholding Treatment
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Eosinophilic esophagitis (EoE), when left untreated, may progress from an inflammatory to a fibrostenotic phenotype. Inflammation generally recurs after treatment withdrawal. Thus, long-term treatment has been recommended. Here, we describe a cohort of children with EoE who achieved clinical and histologic remission with elimination diets, and maintained sustained untreated remission (SUR) despite re-introduction of all eliminated food allergens., (Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.)
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- 2020
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11. Letter: reassuringly normal response to ACTH in children treated with swallowed topical corticosteroids for eosinophilic oesophagitis.
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Rodríguez Manchón S, Domínguez Ortega G, Bacelo Ruano I, Martínez Ibeas MA, Pozo Román J, Cañedo Villarroya E, and Muñoz Codoceo RA
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- Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Child, Fluticasone, Humans, Adrenal Insufficiency, Eosinophilic Esophagitis
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- 2019
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12. Food Protein-induced Enterocolitis Syndrome: Data From a Multicenter Retrospective Study in Spain.
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Díaz JJ, Espín B, Segarra O, Domínguez-Ortega G, Blasco-Alonso J, Cano B, Rayo A, and Moreno A
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- Child, Child, Preschool, Enterocolitis etiology, Female, Food Hypersensitivity complications, Humans, Infant, Male, Retrospective Studies, Spain epidemiology, Syndrome, Allergens adverse effects, Dietary Proteins adverse effects, Enterocolitis epidemiology, Food Hypersensitivity epidemiology
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Objective: The aim of the study was to describe clinical, epidemiological, and management characteristics of food protein-induced enterocolitis syndrome (FPIES) cases in Spain., Patients and Methods: Multicenter observational retrospective study. FPIES cases diagnosed in specialized units in Spain over 12 months in 2017 (January-December) according to the recently published international diagnostic criteria were included., Results: One hundred twenty patients (53.3% boys) were included. The majority were acute cases (111) with mild-to-moderate severity (76.7%). Triggering foods were cow's milk (48/120), fish (38), egg (13), rice (12), and soy (1). The majority (84.2%) of the patients had FPIES to 1 food only. In addition to vomiting (100%), pallor (89.2%), and altered behavior (88.3%) were most frequently observed in acute forms. On the contrary, diarrhea (70%), abdominal distension (33.3%), and blood in stools (44.4%) were more frequently observed in chronic cases. Oral challenge was performed in 18.9% of the acute forms compared to 44.4% of the chronic forms. The most common treatment was intravenous fluids followed by ondansetron. Corticosteroids were used in 6 patients (5 with acute symptoms and 1 chronic). Seven patients were treated with antibiotics for suspicion of infection. Most cases of cow's milk FPIES were treated with extensively hydrolyzed formulas (69.8%)., Conclusions: FPIES is not uncommon in our units. Unlike other published series, fish and egg are important triggers in our country. A greater knowledge and diffusion of the international consensus criteria will allow a better characterization of the cases and a standardization of their management.
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- 2019
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