119 results on '"Dohan, D."'
Search Results
2. Observation and analysis of self-amplified spontaneous emission at the APS low-energy undulator test line
- Author
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Arnold, N.D, Attig, J, Banks, G, Bechtold, R, Beczek, K, Benson, C, Berg, S, Berg, W, Biedron, S.G, Biggs, J.A, Borland, M, Boerste, K, Bosek, M, Brzowski, W.R, Budz, J, Carwardine, J.A, Castro, P, Chae, Y.-C, Christensen, S, Clark, C, Conde, M, Crosbie, E.A, Decker, G.A, Dejus, R.J, DeLeon, H, Den Hartog, P.K, Deriy, B.N, Dohan, D, Dombrowski, P, Donkers, D, Doose, C.L, Dortwegt, R.J, Edwards, G.A, Eidelman, Y, Erdmann, M.J, Error, J, Ferry, R, Flood, R, Forrestal, J, Freund, H, Friedsam, H, Gagliano, J, Gai, W, Galayda, J.N, Gerig, R, Gilmore, R.L, Gluskin, E, Goeppner, G.A, Goetzen, J, Gold, C, Gorski, A.J, Grelick, A.E, Hahne, M.W, Hanuska, S, Harkay, K.C, Harris, G, Hillman, A.L, Hogrefe, R, Hoyt, J, Huang, Z, Jagger, J.M, Jansma, W.G, Jaski, M, Jones, S.J, Keane, R.T, Kelly, A.L, Keyser, C, Kim, K.-J, Kim, S.H, Kirshenbaum, M, Klick, J.H, Knoerzer, K, Koldenhoven, R.J, Knott, M, Labuda, S, Laird, R, Lang, J, Lenkszus, F, Lessner, E.S, Lewellen, J.W, Li, Y, Lill, R.M, Lumpkin, A.H, Makarov, O.A, Markovich, G.M, McDowell, M, McDowell, W.P, McNamara, P.E, Meier, T, Meyer, D, Michalek, W, Milton, S.V, Moe, H, Moog, E.R, Morrison, L, Nassiri, A, Noonan, J.R, Otto, R, Pace, J, Pasky, S.J, Penicka, J.M, Pietryla, A.F, Pile, G, Pitts, C, Power, J, Powers, T, Putnam, C.C, Puttkammer, A.J, Reigle, D, Reigle, L, Ronzhin, D, Rotela, E.R, Russell, E.F, Sajaev, V, Sarkar, S, Scapino, J.C, Schroeder, K, Seglem, R.A, Sereno, N.S, Sharma, S.K, Sidarous, J.F, Singh, O, Smith, T.L, Soliday, R, Sprau, G.A, Stein, S.J, Stejskal, B, Svirtun, V, Teng, L.C, Theres, E, Thompson, K, Tieman, B.J, Torres, J.A, Trakhtenberg, E.M, Travish, G, Trento, G.F, Vacca, J, Vasserman, I.B, Vinokurov, N.A, Walters, D.R, Wang, J, Wang, X.J, Warren, J, Wesling, S, Weyer, D.L, Wiemerslage, G, Wilhelmi, K, Wright, R, Wyncott, D, Xu, S, Yang, B.-X, Yoder, W, and Zabel, R.B
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- 2001
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3. EngageUC: Developing an Efficient and Ethical Approach to Biobanking Research at the University of California
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Garrett, SB, Koenig, BA, Brown, A, Hult, JR, Boyd, EA, Dry, S, Dohan, D, Berglund, L, Dubinett, S, Firestein, G, Grady, D, Daniel Mercola, Johnston, SC, Sak, R, Cavaleri, G, Longstaff, H, and Burgess, M
- Subjects
Biomedical Research ,Informed Consent ,Cardiovascular Medicine And Haematology ,Oncology And Carcinogenesis ,Universities ,population ,in collaboration with UC BRAID ,patients ,translational research ,biorepositories ,Other Medical And Health Sciences ,Humans ,General Clinical Medicine ,Biological Specimen Banks - Abstract
© 2015 Wiley Periodicals, Inc.. Biorepositories, or biobanks, provide researchers with access to biological samples and associated data in support of translational research. Efficient operation and ethical stewardship of biobanks involves coordinated efforts among multiple stakeholders including researchers who manage and use the repository, institutional officials charged with its oversight, and patients and volunteers who contribute samples and data. As advancements in translational research increasingly involve more data derived from larger numbers of diverse samples, the size and governance challenges facing biorepositories have grown. We describe an approach to developing efficient and ethical biobank governance that includes all major stakeholders. This model provides a pathway for addressing the technical and ethical challenges that must be resolved to ensure biorepositories continue to support translational research.
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- 2015
4. AnomalousK-conversion coefficient of the 124keV transition in131Cs
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Sen, S. K., Rizvi, S. I. H., and Dohan, D. A.
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- 1968
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5. Decision Support System for the APS Control System
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Dohan, D. A.
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Accelerator Physics (physics.acc-ph) ,FOS: Physical sciences ,Physics - Accelerator Physics - Abstract
The Advanced Photon Source is now in its fifth year of routine beam production. The EPICS-based [1] control system has entered the phase in its life cycle where new control algorithms must be implemented under increasingly stringent operational and reliability requirements. The sheer volume of the control system (~270,000 records, ~145 VME-based input-output controllers (IOCs), and ~7,000,000 lines of EPICS ASCII configuration code), presents a daunting challenge for code maintenance. The present work describes a relational database that provides an integrated view of the interacting components of the entire APS control system, including the IOC low-level logic, the physical wiring documentation, and high-level client applications. The database is extracted (booted) from the same operational CVS repository as that used to load the active IOCs. It provides site-wide decision support facilities to inspect and trace control flow and to identify client (e.g., user interface) programs involved at any selected point in the front-end logic. The relational database forms a basis for generalized documentation of global control logic and its connection with both the physical I/O and with external high-level applications., Presented (WEET001) at ICALEPCS 2001, San Jose CA, Nov. 27-30, 2001 3 pages, 1 figure, PDF
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- 2001
6. Testing and Implementation Progress on the Advanced Photon Source (APS) Linear Accelerator (Linac) High-Power S-band Switching System
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Grelick, A. E., Arnold, N., Berg, S., Dohan, D., Goeppner, G., Kang, Y. W., Nassiri, A., Pasky, S., Pile, G., Smith, T., and Stein, S. J.
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Accelerator Physics (physics.acc-ph) ,FOS: Physical sciences ,Physics - Accelerator Physics - Abstract
An S-band linear accelerator is the source of particles and the front end of the Advanced Photon Source injector. In addition, it supports a low-energy undulator test line (LEUTL) and drives a free-electron laser (FEL). A waveguide-switching and distribution system is now under construction. The system configuration was revised to be consistent with the recent change to electron-only operation. There are now six modulator-klystron subsystems, two of which are being configured to act as hot spares for two S-band transmitters each, so that no single failure will prevent injector operation. The two subsystems are also used to support additional LEUTL capabilities and off-line testing. Design considerations for the waveguide-switching subsystem, topology selection, control and protection provisions, high-power test results, and current status are described, Linac 2000 paper No. THE07 3 pages with 3 figures
- Published
- 2000
7. Recruitment practices and the politics of inclusion in cancer clinical trials.
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Joseph G, Dohan D, Joseph, Galen, and Dohan, Daniel
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Since the U.S. National Institutes of Health (NIH) Revitalization Act of 1993, researchers with federal funding have been required to include "minorities and women" in their clinical trials, and inclusion in research has come to be seen as an important strategy for reducing health disparities. On the basis of ethnographic research in oncology clinics in an academic medical center and a public hospital over a period of two years, this article examines how the NIH inclusion mandate is playing out in the context of oncology clinical trials. We argue that although individual patients are recruited to particular trials by individual providers, recruitment processes are shaped by the structural inequities in the U.S. health care system that create differential access to medical facilities with different and unequal research infrastructures. Given the heterogeneity of clinical trials, research infrastructures, and the U.S. health care system, the meanings of inclusion in research are multiple, and inclusion by itself does not ensure equity. [ABSTRACT FROM AUTHOR]
- Published
- 2012
8. How a cancer education group serves the underserved: 'Family' ties and battling cancer.
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Dohan D, Szolarova R, and Walcer B
- Abstract
OBJECTIVE: Socially disadvantaged cancer patients have unmet educational needs, but we know little about how educational groups might help. This exploratory study examines how a group education program met underserved patients' needs. METHODS: We examined a program for US patients in a safety-net hospital that featured English and Spanish language groups. We collected data from 54 group sessions over 28 months, including information on participant demographics, attendance, and satisfaction. Qualitative field notes collected by trained observers were analyzed via a grounded-theory approach to examine group dynamics. RESULTS: Participants were underserved, had diverse disease sites and race/ethnicity, and reported that groups met their needs. Emergent analysis identified two themes related to group dynamics. First, members identified with each other as a fictive family, although the meaning of 'family' differed in the groups. Second, groups focused on battling cancer not adjusting to life as a survivor-a focus that impaired participants' ability to discuss coping strategies for managing negative feelings. CONCLUSION: Fictive 'family' engages participants. The emphasis on 'family' and resistance to coping strategies may reflect participants' social disadvantages. PRACTICE IMPLICATIONS: Groups for the underserved should strive to create a 'family' and may have difficulty helping participants cope with their illness. [ABSTRACT FROM AUTHOR]
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- 2012
9. Metrics for evaluating patient navigation during cancer diagnosis and treatment: crafting a policy-relevant research agenda for patient navigation in cancer care.
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Guadagnolo BA, Dohan D, Raich P, Guadagnolo, B Ashleigh, Dohan, Daniel, and Raich, Peter
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Background: Racial and ethnic minorities as well as other vulnerable populations experience disparate cancer-related health outcomes. Patient navigation is an emerging health care delivery innovation that offers promise in improving quality of cancer care delivery to these patients who experience unique health-access barriers. Metrics are needed to evaluate whether patient navigation can improve quality of care delivery, health outcomes, and overall value in health care during diagnosis and treatment of cancer.Methods: Information regarding the current state of the science examining patient navigation interventions was gathered via search of the published scientific literature. A focus group of providers, patient navigators, and health-policy experts was convened as part of the Patient Navigation Leadership Summit sponsored by the American Cancer Society. Key metrics were identified for assessing the efficacy of patient navigation in cancer diagnosis and treatment.Results: Patient navigation data exist for all stages of cancer care; however, the literature is more robust for its implementation during prevention, screening, and early diagnostic workup of cancer. Relatively fewer data are reported for outcomes and efficacy of patient navigation during cancer treatment. Metrics are proposed for a policy-relevant research agenda to evaluate the efficacy of patient navigation in cancer diagnosis and treatment.Conclusions: Patient navigation is understudied with respect to its use in cancer diagnosis and treatment. Core metrics are defined to evaluate its efficacy in improving outcomes and mitigating health-access barriers. [ABSTRACT FROM AUTHOR]- Published
- 2011
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10. Diversity of participants in clinical trials in an academic medical center: the role of the 'Good Study Patient?'.
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Joseph G and Dohan D
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- 2009
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11. Possible involvement of gelatinase A (MMP2) and gelatinase B (MMP9) in toxic epidermal necrolysis or Stevens-Johnson syndrome.
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F.Gaultier, Ejeil, A.-L., Igondjo-Tchen, S., Dohan, D., Dridi, S. M., Maman, L., Wierzba, C. B., Stania, D., Pellat, B., Lafont, A., Godeau, G., and Gogly, B.
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EPIDERMAL diseases ,MUCOCUTANEOUS lymph node syndrome ,NECROSIS ,PATIENTS ,CELL culture ,SKIN diseases - Abstract
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered to be drug-induced diseases, and are characterized by extensive mucocutaneous disorder and epidermal necrosis which result in the detachment of the epidermis. Inactive and active forms of metalloproteinases (MMP2 and MMP9) secreted by skin explants maintained in organ culture for 72 h and in blister fluid from two TEN and three SJS patients were investigated. Interestingly, lesional skin from both the TEN and the SJS patients cultured for 3 days in conditioned medium showed high levels of both 72 kDa progelatinase A and 66 kDa activated gelatinase A, and the 66 kDa activated form was not observed in cultures of skin from control individuals. Furthermore, indirect immunodetection showed the presence of MMP2 and MMP9 in TEN and SJS patients' skin. Increased gelatinase activity in the culture medium of TEN and SJS skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for the detachment of the epidermis in these drug-induced necrolyses. [ABSTRACT FROM AUTHOR]
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- 2004
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12. The decay of 233U.
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Canty, M J, Connor, R D, Dohan, D A, and Pople, B
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- 1977
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13. Computer Control Strategies at SIN.
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Adam, S., Blumer, F., Collins, J. C., Dohan, D. A., Rohrer, U., Steiner, E., and Ziegler, P.
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- 1979
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14. Anomalous K-conversion coefficient of the 124keV transition inCs.
- Author
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Sen, S., Rizvi, S., and Dohan, D.
- Abstract
The absolute K-conversion coefficients of the 496 keV-124 keV cascade γ-rays inCs have been determined from angular correlation experiments using a new approach. The value of α=0.0100±0.0007 obtained for the 496 keV transition is in excellent agreement with the theory whereas a strong case is presented for the existence of an anomalous nuclear-structure-dependent conversion coefficient for the 124 keV transition. The K-conversion coefficient for this transition has been measured to be 0.742±0.077 giving a value of 1.25±0.13 for the ratio α/ α. The result is interpreted as being due to the presence of electric monopole, E0, electron transition. A value of 0.26±0.14 has been obtained for the E0/ E2 electron conversion ratio and the absolute value of the electric monopole matrix element has been determined to be 0.07±0.02. [ABSTRACT FROM AUTHOR]
- Published
- 1968
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15. REDUCTION OF MULTIPACTORING EFFECTS IN THE TRIUMF CYCLOTRON.
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Pacak, V., Dohan, D., Fong, K., Worsham, R., and Dutto, G.
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SIGNAL-to-noise ratio ,PARTICLE acceleration ,ION sources ,CYCLOTRONS ,PARTICLE accelerator design & construction ,NUCLEAR energy - Published
- 1991
16. Requirements for a new resonator structure at TRIUMF
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Dohan, D A, Dutto, G, Fong, K W, Laxdal, R, Pacak, V, Poirier, R, Worsham, R, and Zach, M P
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Accelerators and Storage Rings - Published
- 1984
17. Third harmonic flattopping in the TRIUMF rf cavity
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Enegren, T A, Dohan, D A, Fong, K W, Pacak, V, and Worsham, R
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Accelerators and Storage Rings - Published
- 1986
18. Precision NMR measurement of the TRIUMF cyclotron magnetic field
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Burge, R S, Dennison, G, and Dohan, D A
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Accelerators and Storage Rings - Published
- 1984
19. Control of rf leakage in the TRIUMF cyclotron
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Dohan, D A, Fong, K W, and Pacak, V
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Accelerators and Storage Rings - Published
- 1986
20. System for flat-topping the rf voltage at TRIUMF
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Worsham, R E, Enegren, T A, Dohan, D A, Durieu, L, and Poirier, R
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Accelerators and Storage Rings - Published
- 1984
21. Developments toward separated turns at TRIUMF
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Blackmore, E W, Dohan, D A, MacKenzie, G H, and Poirier, R
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Accelerators and Storage Rings - Published
- 1981
22. Stability improvements in the TRIUMF cyclotron magnetic field to $\pm$0.7 ppm
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Reiniger, K W, Baumann, H, Dohan, D A, and Pearce, D R
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Accelerators and Storage Rings - Published
- 1984
23. Improved reliability of the TRIUMF resonator system through installation of new resonator panels
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Worsham, R, Dohan, D A, Dutto, G, Fong, K W, Poirier, R, and Stanford, G S
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Accelerators and Storage Rings - Published
- 1986
24. Modelling the TRIUMF RF Cavity Using the Code RFQ3D.
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Dohan, D., Fong, K., and Hutcheon, R.
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- 1985
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25. Model Study on the Reduction of RF Leakage in the TRIUMF Cyclotron.
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Fong, K., Dohan, D. A., Pacak, V., and Hutcheon, R.
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- 1985
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26. Determination of the RF Leakage Field in the Vacuum Tank of the TRIUMF Cyclotron.
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Poirier, R., Dohan, D., Dutto, G., Enegren, T. A., Fong, K., Pacak, V., and Hohbach, R.
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- 1983
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27. Progress Towards Higher Intensities and Improved Beam Stability at TRIUMF.
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Schmor, P. W., Baartman, R., Carey, J. W., Dohan, D., Dutto, G., and Mackenzie, G. H.
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- 1983
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28. Beam Developments at TRIUMF.
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Baartman, R., Beveridge, J., Blackmore, E. W., Craddock, M. K., Dohan, D., Doornbos, J., Dutto, G., Erdman, K. L., Kost, C. J., Laxdal, R., Macdonald, J. A., Mackenzie, G. H., Schmor, P. W., and Vincent, J. S.
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- 1981
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29. TRIUMF KAON Factory pre-construction study.
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Craddock, M.K., Astbury, A., Axen, D., Baartman, R., Barnes, M., Beveridge, J., Blackmore, E.W., Burge, R., Carey, J., Clark, G., Dawson, W.K., Dohan, D., Doornbos, J., Dutto, G., Enegren, T., Frammery, B., Haddock, C., Hodges, T.A., Kitching, P., and Koscielniak, S.
- Published
- 1989
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30. The interaction between the third harmonic resonance and parasitic modes inside the TRIUMF cavity.
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Pacak, V., Fong, K., Dohan, D., and Enegren, T.
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- 1989
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31. Decision support facility for the APS control system.
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Dohan, D
- Published
- 2001
32. Connection oriented related database of the APS control system hardware.
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Dohan, D
- Published
- 2003
33. Nuclear structure of $sup 70$Ga
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Dohan, D
- Published
- 1973
34. ANOMALOUS K-CONVERSION COEFFICIENT OF THE 124-keV TRANSITION IN $sup 131$Cs.
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Dohan, D
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- 1968
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35. ELECTRON-GAMMA AND GAMMA-ELECTRON DIRECTIONAL CORRELATION EXPERIMENTS ON THE 496 keV--124 keV CASCADE IN $sup 131$Cs.
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Dohan, D
- Published
- 1967
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36. Improving Surgical Care and Outcomes in Older Cancer Patients Through Implementation of a Presurgical Toolkit (OPTI-Surg)-Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD).
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Chang GJ, Gunn HJ, Barber AK, Lowenstein LM, Dohan D, Broering J, Dockter T, Tan AD, Dueck A, Chow S, Neuman H, and Finlayson E
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- Humans, Aged, Male, Female, Aged, 80 and over, Preoperative Care methods, Frailty complications, Quality Improvement, Postoperative Complications epidemiology, Neoplasms surgery, Geriatric Assessment
- Abstract
Objective: To assess the effect of a practice-level preoperative frailty screening and optimization toolkit (OPTI-Surg) on postoperative functional recovery and complications in elderly cancer patients undergoing major surgery., Background: Frailty is common in older adults. It increases the risk of poor postoperative functional recovery and complications. The potential for a practice-level screening/optimization intervention to improve outcomes is unknown., Methods: Thoracic, gastrointestinal, and urologic oncological surgery practices within the National Cancer Institute Community Oncology Research Program (NCORP) were randomized 1:1:1 to usual care (UC), OPTI-Surg, or OPTI-Surg with an implementation coach. OPTI-Surg consisted of the Edmonton Frail Scale and guided recommendations for referral interventions. Patients 70 years old or above undergoing curative intent surgery were eligible. The primary outcome was 8 weeks postoperative function (kcal/wk). The key secondary outcome was complications within 90 days. Mixed models were used to compare UC to the 2 OPTI-Surg arms combined., Results: From July 2019 to September 2022, 325 patients were enrolled in 29 practices. One hundred ninety-nine (64 UC, 135 OPTI-Surg) and 279 (78 UC, 201 OPTI-Surg) were evaluable for primary and secondary analysis, respectively. UC and OPTI-Surg patients did not significantly differ in total caloric expenditure (2.2 UC, 2.0 OPTI-Surg) after adjusting for baseline function ( P =0.53). UC and OPTI-Surg patients did not significantly differ in postoperative complications (25.6% UC, 35.3% OPTI-Surg, P =0.5)., Conclusions: Frailty assessment was successfully performed, but the OPTI-Surg intervention did not improve postoperative function nor reduce postoperative complications compared with UC. Future analysis will explore practice-level factors associated with toolkit implementation and the differences between the coaching and noncoaching arms., Competing Interests: E.F. is a founding shareholder of Ooney. The remaining authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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37. "I'm worth saving"- A Qualitative Study of People with Alzheimer's Disease Considering Lecanemab Treatment.
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Parks AL, Thacker A, Dohan D, Gomez LAR, Ritchie CS, Paladino J, and Shah SJ
- Abstract
Importance: People with Alzheimer's disease (AD) now have access to disease-modifying treatment with anti-amyloid monoclonal antibodies (mAbs). Their perception of risks and benefits and approach to treatment decisions remain unknown., Objective: To understand how people with early AD consider benefits and costs of anti-amyloid mAbs and make decisions about treatment., Design: Qualitative semi-structured interviews., Setting: Memory care clinics at two academic medical centers., Participants: People with biomarker or imaging-confirmed early AD referred for evaluation for treatment with anti-amyloid mAbs., Main Outcomes and Measures: Themes identified through content analysis., Results: Among 22 participants, mean age was 70 years, 8 (36%) were women, 22 (100%) were White, 8 (36%) had less than a college degree, 11 (50%) had annual income less than $100,000, and 6 (27%) lived in a rural area. The analysis revealed 3 major themes and associated subthemes: 1) People with AD sought and obtained information from different sources-advocacy organizations, the Internet, and clinicians; 2) hopes, expected benefits, and the existential threat of dementia drove willingness and readiness to start lecanemab-hopes included more time feeling like themselves and doing enjoyable activities; expected benefits included stalling progression, reversing cognitive decline or cure; 3) individual traits and preferences, family factors, and degree of trust in expertise influenced how people balanced risks and benefits- some would accept treatment at any cost; others carefully weighed risks and burdens carefully, but were motivated to pursue treatment by supportive families, insurance coverage, and trust in expertise; for a few, costs decidedly outweighed their personal benefits. People with AD desired more individualized information on risks and benefits and wanted to hear more from patients who took the medication., Conclusions and Relevance: Results from this qualitative analysis inform clinician, health system and policy efforts to promote individualized treatment decisions for anti-amyloid mAb treatment through multimodal education and outreach, evidence-based communication skills, and adaptation of similar care models., Key Points: Question: How do people with Alzheimer's disease (AD) decide on treatment with newly available anti-amyloid monoclonal antibodies? Findings: In this qualitative analysis, people with AD considering treatment relied on multiple information sources; were motivated by hope to delay cognitive decline and preserve independence; and worried side effects would impair quality of life. Personality traits, family support, and trust in expertise determined how they balanced these tradeoffs. People with AD wanted more personalized information and to hear from others who had taken the medications. Meaning: As access to treatment expands, these findings inform how clinicians can help people with AD make individualized treatment decisions.
- Published
- 2024
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38. Race-Ethnicity, Rurality, and Age in Prospective Preferences and Concerns Regarding Closed-Loop Implanted Neural Devices.
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Chen BB, Haeusermann T, Dada A, Hamilton RH, James JE, Fong KC, Dohan D, and Chiong W
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Objective: Responsive and human-centered neurotechnology development requires attention to public perceptions, particularly among groups underserved by existing treatments., Methods: The authors conducted a preregistered nationally representative survey (https://osf.io/ej9h2) using the NORC at the University of Chicago AmeriSpeak panel. One vignette compared an implanted neural device with surgical resection in a scenario involving epilepsy, and another compared an implanted neural device with medications in a scenario involving mood disorders. The survey also contained questions about respondents' confidence that a device would be available if needed and confidence that enough research has been conducted among people like themselves. Responses were entered into nested survey-weighted logistic regression models, including a base demographic model (to test the overall effect of demographic factors) and an adjusted model that also included socioeconomic, religious and political, and health care access predictors., Results: A total of 1,047 adults responded to the survey, which oversampled Black non-Hispanic (N=214), Hispanic (N=210), and rural (N=219) Americans. In the base demographic model, older Americans were more likely to prefer an implanted device in the two scenarios, and non-Hispanic Black Americans were less likely than non-Hispanic White Americans to prefer a device; rural Americans were less confident than urban or suburban Americans in having access, and non-Hispanic Black and rural Americans were less confident that enough research has been conducted among people like themselves. In adjusted models, income was a key mediator, partially explaining the effect of age and the contrast between Black and White non-Hispanic respondents on preferences for a device in the epilepsy scenario and fully explaining the effect of rurality on confidence in access., Conclusions: Demographic differences in prospective preferences and concerns highlight the importance of including members of underserved communities in neurotechnology development., Competing Interests: The authors report no financial relationships with commercial interests.
- Published
- 2024
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39. Perspectives on Referral Pathways for Timely Head and Neck Cancer Care.
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Batool S, Hansen EE, Sethi RKV, Rettig EM, Goguen LA, Annino DJ, Uppaluri R, Edwards HA, Faden DL, Schnipper JL, Dohan D, Reich AJ, and Bergmark RW
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- Humans, Male, Female, Middle Aged, Aged, Adult, Interviews as Topic, Time-to-Treatment, Referral and Consultation, Head and Neck Neoplasms therapy, Head and Neck Neoplasms diagnosis, Triage, Qualitative Research
- Abstract
Importance: Timely diagnosis and treatment are of paramount importance for patients with head and neck cancer (HNC) because delays are associated with reduced survival rates and increased recurrence risk. Prompt referral to HNC specialists is crucial for the timeliness of care, yet the factors that affect the referral and triage pathway remain relatively unexplored. Therefore, to identify barriers and facilitators of timely care, it is important to understand the complex journey that patients undertake from the onset of HNC symptoms to referral for diagnosis and treatment., Objective: To investigate the referral and triage process for patients with HNC and identify barriers to and facilitators of care from the perspectives of patients and health care workers., Design, Participants, and Setting: This was a qualitative study using semistructured interviews of patients with HNC and health care workers who care for them. Participants were recruited from June 2022 to July 2023 from HNC clinics at 2 tertiary care academic medical centers in Boston, Massachusetts. Data were analyzed from July 2022 to December 2023., Main Outcomes and Measures: Themes identified from the perspectives of both patients and health care workers on factors that hinder or facilitate the HNC referral and triage process., Results: In total, 72 participants were interviewed including 42 patients with HNC (median [range] age, 60.5 [19.0-81.0] years; 27 [64%] females) and 30 health care workers (median [range] age, 38.5 [20.0-68.0] years; 23 [77%] females). Using thematic analysis, 4 major themes were identified: the HNC referral and triage pathway is fragmented; primary and dental care are critical for timely referrals; efficient interclinician coordination expedites care; and consistent patient-practitioner engagement alleviates patient fear., Conclusions and Relevance: These findings describe the complex HNC referral and triage pathway, emphasizing the critical role of initial symptom recognition, primary and dental care, patient information flow, and interclinician and patient-practitioner communication, all of which facilitate prompt HNC referrals.
- Published
- 2024
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40. Primary care clinician perspectives on automated nephrology e-consults for diabetic kidney disease: a pre-implementation qualitative study.
- Author
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Chu CD, Dohan D, Estrella MM, Shlipak MG, and Tuot DS
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- Humans, Male, Female, Nephrology, Primary Health Care, Interviews as Topic, Remote Consultation, Qualitative Research, Diabetic Nephropathies therapy, Physicians, Primary Care, Attitude of Health Personnel
- Abstract
Background: Many patients with diabetic kidney disease (DKD) do not receive evidence-based, guideline-recommended treatment shown to reduce DKD progression and complications. Proactive electronic consultations (e-consults) are an emerging intervention strategy that could potentially allow nephrologists to provide timely and evidence-based guidance to primary care providers (PCPs) engaged in early DKD care., Methods: The objective of this study was to explore perspectives about potential barriers and facilitators associated with a proactive e-consult program to improve DKD care delivery. We conducted semi-structured qualitative interviews with PCPs across three different health systems. Interview transcripts were reviewed in a rapid qualitative analysis approach to iteratively identify, refine, and achieve consensus on a final list of themes and subthemes., Results: A total of 18 interviews were conducted. PCPs across all sites identified similar challenges to delivering guideline-recommended DKD care. PCPs were supportive of the proactive e-consult concept. Three major themes emerged surrounding (1) perceived potential benefits of proactive e-consults, including educational value and improved specialist access; (2) concerns about the proactive nature of e-consults, including the potential to increase PCP workload and the possibility that e-consults could be seen as documenting substandard care; and (3) leveraging of care teams to facilitate recommended DKD care, such as engaging clinic-based pharmacists to implement specialist recommendations from e-consults., Conclusion: In this pre-implementation qualitative study, PCPs noted potential benefits and identified concerns and implementation barriers for proactive e-consults for DKD care. Strategies that emerged for promoting successful implementation included involving clinic support staff to enact e-consult recommendations and framing e-consults as a system improvement effort to avoid judgmental associations., (© 2024. The Author(s).)
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- 2024
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41. Patient experiences of resection versus responsive neurostimulation for drug-resistant epilepsy.
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Haeusermann T, Liu EY, Fong KC, Dohan D, and Chiong W
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- Humans, Electrocorticography, Patient Outcome Assessment, Drug Resistant Epilepsy surgery, Epilepsy surgery, Deep Brain Stimulation
- Abstract
This study explored illness experiences and decision-making among patients with epilepsy who underwent two different types of surgical interventions: resection versus implantation of the NeuroPace Responsive Neurostimulation System (RNS). We recruited 31 participants from a level four epilepsy center in an academic medical institution. We observed 22 patient clinic visits (resection: n = 10, RNS: n = 12) and conducted 18 in-depth patient interviews (resection: n = seven, RNS: n = 11); most visits and interviews included patient caregivers. Using an applied ethnographic approach, we identified three major themes in the experiences of resection versus RNS patients. First, for patients in both cohorts, the therapeutic journey was circuitous in ways that defied standardized first-, second-, and third- line of care models. Second, in conceptualizing risk, resection patients emphasized the permanent loss of "taking out" brain tissue whereas RNS patients highlighted the reversibility of "putting in" a device. Lastly, in considering benefit, resection patients perceived their surgery as potentially curative while RNS patients understood implantation as primarily palliative with possible additional diagnostic benefit from chronic electrocorticography. Insight into the perspectives of patients and caregivers may help identify key topics for counseling and exploration by clinicians., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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42. Personal Social Networks and Care-Seeking for Head and Neck Cancer: A Qualitative Study.
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Batool S, Hansen EE, Sethi RKV, Rettig EM, Goguen LA, Annino D, Uppaluri R, Edwards HA, Faden DL, Dohan D, Dhand A, Reich AJ, and Bergmark RW
- Subjects
- Humans, Female, Adolescent, Adult, Middle Aged, Male, Qualitative Research, Health Personnel, Social Networking, Patient Acceptance of Health Care, Head and Neck Neoplasms therapy
- Abstract
Objectives: To investigate the role of patients' personal social networks (SNs) in accessing head and neck cancer (HNC) care through patients' and health care workers' (HCWs) perspectives., Study Design: Qualitative study., Setting: Tertiary HNC centers at 2 academic medical centers, including 1 safety net hospital., Methods: Patients with newly diagnosed HNC, and HCWs caring for HNC patients, aged ≥18 years were recruited between June 2022 and July 2023. Semistructured interviews were conducted with both patients and HCWs. Inductive and deductive thematic analysis was performed with 2 coders (κ = 0.82) to analyze the data., Results: The study included 72 participants: 42 patients (mean age 57 years, 64% female, 81% white), and 30 HCWs (mean age 42 years, 77% female, 83% white). Four themes emerged: (1) Patients' SNs facilitate care through various forms of support, (2) patients may hesitate to seek help from their networks, (3) obligations toward SNs may act as barriers to seeking care, and (4) the SN composition and dedication influence care-seeking., Conclusion: Personal SNs play a vital role in prompting early care-seeking among HNC patients. SN-based interventions could enhance care and improve outcomes for HNC patients., (© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2024
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43. How older men live with stress urinary incontinence: Patient experience and navigation to treatment.
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Shaw NM, Breyer BN, Walter LC, Sudore RL, Suskind AM, Baussan C, Quanstrom K, Allen IE, Cooperberg MR, Dohan D, and Hampson LA
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- Male, Humans, Aged, Quality of Life, Treatment Outcome, Patient Outcome Assessment, Urinary Incontinence, Stress surgery, Urinary Sphincter, Artificial, Urinary Incontinence
- Abstract
Objectives: To explore the context in which older men navigate treatment for stress urinary incontinence (SUI) following prostate surgery by characterizing lived experience of men with symptomatic SUI., Subjects/patients and Methods: Mixed method study using surveys and semistructured interviews to examine a cohort of men who underwent evaluation for treatment of postprostatectomy SUI., Results: Thirty-six men were interviewed after consultation for SUI and 31 had complete quantitative clinical data. Twenty-six underwent surgery and 10 chose no surgical intervention. In qualitative interviews, respondents experienced substantial decline in quality of life due to incontinence citing concerns associated with use of pads and worrying about incontinence. Most patients reported "workarounds"-efforts to mitigate or manage incontinence including Kegels, physical therapy, and garments. Participants also reported lifestyle changes including less strenuous physical activity, less sexual activity, and/or fewer social gatherings. Patients then described a "breaking point" where incontinence workarounds were no longer sufficient. After seeking evaluation, men described challenges in exploring treatment for SUI, including access to care and provider knowledge of treatment options., Conclusion: In a novel study of patients living with SUI a predictable lived experience was observed that culminated in a desire for change or "breaking point." In all men, this led to treatment-seeking behaviors and for many it led to SUI intervention. Despite effective treatments, patients continue to meet barriers gaining access to SUI evaluation and treatment., (© 2023 Wiley Periodicals LLC.)
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- 2024
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44. Primary Care Pracitioner Perspectives on the Role of Primary Care in Dementia Diagnosis and Care.
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Sideman AB, Ma M, Hernandez de Jesus A, Alagappan C, Razon N, Dohan D, Chodos A, Al-Rousan T, Alving LI, Segal-Gidan F, Rosen H, Rankin KP, Possin KL, and Borson S
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- Female, Humans, Male, Health Personnel, United States, Physician's Role, Dementia diagnosis, Dementia therapy, Primary Health Care, Physicians, Primary Care
- Abstract
Importance: Although the barriers to dementia care in primary care are well characterized, primary care practitioner (PCP) perspectives could be used to support the design of values-aligned dementia care pathways that strengthen the role of primary care., Objective: To describe PCP perspectives on their role in dementia diagnosis and care., Design, Setting, and Participation: In this qualitative study, interviews were conducted with 39 PCPs (medical doctors, nurse practitioners, and doctors of osteopathic medicine) in California between March 2020 and November 2022. Results were analyzed using thematic analysis., Main Outcomes and Measures: Overarching themes associated with PCP roles in dementia care., Results: Interviews were conducted with 39 PCPs (25 [64.1%] were female; 16 [41%] were Asian). The majority (36 PCPs [92.3%]) reported that more than half of their patients were insured via MediCal, the California Medicaid program serving low-income individuals. Six themes were identified that convey PCPs' perspectives on their role in dementia care. These themes focused on (1) their role as first point of contact and in the diagnostic workup; (2) the importance of long-term, trusting relationships with patients; (3) the value of understanding patients' life contexts; (4) their work to involve and educate families; (5) their activities around coordinating dementia care; and (6) how the care they want to provide may be limited by systems-level constraints., Conclusions and Relevance: In this qualitative study of PCP perspectives on their role in dementia care, there was alignment between PCP perspectives about the core values of primary care and their work diagnosing and providing care for people living with dementia. The study also identified a mismatch between these values and the health systems infrastructure for dementia care in their practice environment.
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- 2023
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45. Hospital Culture and Intensity of End-of-Life Care at 3 Academic Medical Centers.
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Dzeng E, Batten JN, Dohan D, Blythe J, Ritchie CS, and Curtis JR
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- Humans, Female, Hospitals, Academic Medical Centers, Washington, Terminal Care
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Importance: There is substantial institutional variability in the intensity of end-of-life care that is not explained by patient preferences. Hospital culture and institutional structures (eg, policies, practices, protocols, resources) might contribute to potentially nonbeneficial high-intensity life-sustaining treatments near the end of life., Objective: To understand the role of hospital culture in the everyday dynamics of high-intensity end-of-life care., Design, Setting, and Participants: This comparative ethnographic study was conducted at 3 academic hospitals in California and Washington that differed in end-of-life care intensity based on measures in the Dartmouth Atlas and included hospital-based clinicians, administrators, and leaders. Data were deductively and inductively analyzed using thematic analysis through an iterative coding process., Main Outcome and Measure: Institution-specific policies, practices, protocols, and resources and their role in the everyday dynamics of potentially nonbeneficial, high-intensity life-sustaining treatments., Results: A total of 113 semistructured, in-depth interviews (66 women [58.4%]; 23 [20.4%] Asian, 1 [0.9%] Black, 5 [4.4%] Hispanic, 7 [6.2%] multiracial, and 70 [61.9%] White individuals) were conducted with inpatient-based clinicians and administrators between December 2018 and June 2022. Respondents at all hospitals described default tendencies to provide high-intensity treatments that they believed were universal in US hospitals. They also reported that proactive, concerted efforts among multiple care teams were required to deescalate high-intensity treatments. Efforts to deescalate were vulnerable to being undermined at multiple points during a patient's care trajectory by any individual or entity. Respondents described institution-specific policies, practices, protocols, and resources that engendered broadly held understandings of the importance of deescalating nonbeneficial life-sustaining treatments. Respondents at different hospitals reported different policies and practices that encouraged or discouraged deescalation. They described how these institutional structures contributed to the culture and everyday dynamics of end-of-life care at their institution., Conclusions and Relevance: In this qualitative study, clinicians, administrators, and leaders at the hospitals studied reported that they work in a hospital culture in which high-intensity end-of-life care constitutes a default trajectory. Institutional structures and hospital cultures shape the everyday dynamics by which clinicians may deescalate end-of-life patients from this trajectory. Individual behaviors or interactions may fail to mitigate potentially nonbeneficial high-intensity life-sustaining treatments if extant hospital culture or a lack of supportive policies and practices undermine individual efforts. Hospital cultures need to be considered when developing policies and interventions to decrease potentially nonbeneficial, high-intensity life-sustaining treatments.
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- 2023
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46. Patient-identified Treatment Attributes Among Older Men With Stress Urinary Incontinence: A Qualitative Look at What Matters to Patients Making Treatment Decisions.
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Hampson LA, Shaw NM, Breyer BN, Walter LC, Sudore RL, Cooperberg MR, Baussan C, Quanstrom K, Elaine Allen I, and Dohan D
- Subjects
- Male, Humans, Aged, Quality of Life, Urinary Incontinence, Stress surgery, Urinary Incontinence
- Abstract
Objective: To investigate which treatment attributes matter to patients with stress urinary incontinence (SUI), why and how they matter, and the context in which patients consider treatment attributes. Nearly a quarter of older men have decisional regret following SUI treatment. Knowledge of what matters to patients when making SUI treatment decisions is necessary to improve goal-concordant care., Methods: We conducted semi-structured interviews with 36 men ≥65 years of age with SUI. Semi-structured interviews were conducted by telephone and transcribed. Four researchers (L.H., N.S., E.A., C.B.) coded the transcripts using both deductive and inductive codes to identify and describe treatment attributes., Results: We identified 5 patient-derived treatment attributes of interest among older men with SUI who have faced treatment decisions: (1) dryness, (2) simplicity, (3) potential need for future intervention, (4) treatment regret/satisfaction, and (5) surgical avoidance. These themes reliably emerged in our patient-centered interviews from within various contexts, including prior negative healthcare experiences, the impact of incontinence on daily and quality of life, and the mental health burden of incontinence, among others., Conclusion: Men with SUI weigh a variety of treatment attributes in addition to dryness, a traditional clinical endpoint, and do so within the context of their individual experience. These additional attributes, such as simplicity, may run counter to the goal of dryness. This suggests that traditional clinical endpoints alone are not adequate for counseling patients. Contextualized patient-identified treatment attributes should be used to create decision-support materials to promote goal-concordant SUI treatment., Competing Interests: DECLARATION OF COMPETING INTEREST All authors declare no potential conflicts of interest., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2023
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47. The relationship between frailty, incontinence severity, and treatment decisions for men with post-prostatectomy stress urinary incontinence: a mixed methods analysis.
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Jones CP, Shaw NM, Mena J, Breyer BN, Walter LC, Baussan C, Quanstrom K, Allen IE, Dohan D, and Hampson LA
- Abstract
Background: Frailty is common among urology patients in general as well as among men seeking evaluation for stress urinary incontinence (SUI), with 6.1% of men undergoing artificial urinary sphincter placement considered frail. It is unclear if and how patient views on frailty and incontinence severity impact decision-making with regards to SUI treatment., Methods: We undertook a mixed methods analysis to evaluate the intersection of frailty, incontinence severity, and treatment decision-making is presented. To do so, we utilized a previously published cohort of men undergoing evaluation for SUI at the University of California, San Francisco between 2015 and 2020, selecting those who had evaluation with timed up and go test (TUGT), objective measures of incontinence, and patient-reported outcome measures (PROMs). A subset of these participants had additionally undergone semi-structured interviews, and these interviews were re-examined to thematically code them with a focus on the impact of frailty and incontinence severity on SUI treatment decision-making., Results: Among the original cohort of 130 patients, 72 had an objective measure of frailty and were included in our analysis; 18 of these individuals had corresponding qualitative interviews. Common themes identified included (I) impact of incontinence severity on decision-making; (II) the interaction between frailty and incontinence; (III) the impact of comorbidity on treatment decision-making; and (IV) age as a construct of frailty and impact on surgical choice and/or recovery. Direct quotations regarding each theme provides insight into patients' views and drivers of SUI treatment decision-making., Conclusions: The impact of frailty on treatment decision-making for patients with SUI is complex. This mixed methods study highlights the variety of patient views on frailty with regards to surgical intervention for male SUI. Urologists should make a concerted effort to personalize patient counseling for SUI management and take time to understand each patient's perspective in order to individualize SUI treatment decision-making. More research is needed to help identify factors that influence decision-making for frail male patients with SUI., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-22-839/coif). The series “Surgical Management of Stress Urinary Incontinence in Men” was commissioned by the editorial office without any funding or sponsorship. BNB reports that Boston Scientific provides partial funding for the Reconstructive Urology fellowship for which he is the Program Director. LAH served as the unpaid Guest Editor of the series, and she reports that she has spoken and consulted on behalf of Boston Scientific. Boston Scientific is the manufacturer of the artificial urinary sphincter device and urethral sling discussed in this paper. The authors have no other conflicts of interest to declare., (2023 Translational Andrology and Urology. All rights reserved.)
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- 2023
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48. 'It was a great brain, and I miss it': lay perspectives on postoperative cognitive dysfunction.
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Li L, Dohan D, Smith AK, and Whitlock EL
- Subjects
- Humans, Postoperative Complications diagnosis, Brain, Postoperative Cognitive Complications etiology, Anesthesia adverse effects, Anesthetics
- Abstract
Background: Postoperative cognitive dysfunction (POCD) is a concern after anaesthesia and surgery, but preoperative discussion of neurocognitive risks with older patients rarely occurs. Anecdotal experiences of POCD are common in the popular media and may inform patient perspectives. However, the degree of alignment between lay and scientific perspectives on POCD is not known., Methods: We performed inductive qualitative thematic analysis on website user comments publicly submitted under an article entitled, 'The hidden long-term risks of surgery: "It gives people's brains a hard time"', published by the UK-based news source The Guardian in April 2022., Results: We analysed 84 comments from 67 unique users. Themes that emerged from user comments included the importance of functional impact ('Couldn't work … even reading was a struggle'), attribution to a range of causes but particularly the use of general, rather than consciousness-preserving, anaesthesia techniques ('side effects aren't fully understood'), and inadequate preparation and response by healthcare providers ('I would have benefited by being warned')., Conclusions: There is misalignment between professional and lay understandings of POCD. Lay people emphasise subjective and functional impact of symptoms, and express beliefs about the role of anaesthetics in causing POCD. Some patients and caregivers affected by POCD report feeling abandoned by medical providers. In 2018, new nomenclature for postoperative neurocognitive disorders was published, which better aligns with lay perspectives by including subjective complaints and functional decline. Further studies based on newer definitions and public messaging may improve concordance between different understandings of this postoperative syndrome., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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49. Perceptions of and Knowledge Acquisition about Brain Health and Aging among Latin American Immigrants:A QualitativePaper.
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Light SW, Dohan D, Possin KL, Wolf MS, Rankin KP, Lanata S, and Sideman AB
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- Humans, Latin America, Hispanic or Latino psychology, Brain, Emigrants and Immigrants, Dementia
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Objectives: Older immigrants of Latin American descent are disproportionately impacted by dementia, yet little is known about their dementia- and brain health-related knowledge. We explored perspectives on brain health and aging in this population to inform the development of culturally-relevant interventions., Methods: Individual, semi-structured interviews were conducted with 30 Spanish-speaking immigrants over 60. Questions addressed knowledge about the brain, perceptions of healthy and unhealthy aging, ideas of how to take care of one's brain, and where knowledge was acquired. Responses were analyzed using thematic analysis., Results: The following themes emerged: (1) Descriptions of the brain varied, from anatomy, cognition, and psychology to disease. (2) Perceptions of healthy aging included independence, memory, emotions, and orientation. (3) Ideas of how to care for the brain included physical, social, and cognitive engagement. (4) Knowledge was acquired in childhood, communities, healthcare settings, careers, and media., Conclusions: Results showed significant variability in knowledge. Findings may be leveraged to improve interventions that address brain health literacy disparities among older Latin American immigrants., Clinical Implications: Takeaways involve increasing education about the structure and functions of the brain, promoting realistic understandings of what nonnormative brain aging entails, and increasing knowledge of empirically-supported maintenance approaches. Dissemination may be increased via healthcare providers, community centers, churches, and media.
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- 2023
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50. Prosthesis preferences for those with upper limb loss: Discrete choice study of PULLTY® for use in regulatory decisions.
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Wilson L, Dohan D, Garibaldi M, Szeto D, Timmerman M, and Matheny J
- Abstract
Introduction: The patient's voice in shared decision-making has progressed from physician's office to regulatory decision-making for medical devices with FDA's Patient Preference Initiative. A discrete-choice preference measure for upper limb prosthetic devices was developed to investigate patient's risk/benefit preference choices for regulatory decision making., Methods: Rapid ethnographic procedures were used to design a discrete-choice measure describing risk and benefits of osseointegration with myoelectric control and test in a pilot preference study in adults with upper limb loss. Primary outcome is utility of each choice based conjoint (CBC) attribute using mixed-effects regression. Utilities with and without video, and between genders were compared., Results: Strongest negative preference was for avoiding infection risk (B = -1.77, p < 0.001) and chance of daily pain (B = -1.22, p , 0.001). Strongest positive preference was for attaining complete independence when cooking dinner (B = 1.62, p < 0.001) and smooth grip patterns at all levels (B = 1.62, B = 1.28, B = 1.26, p < 0.001). Trade-offs showed a 1% increase in risk of serious/treatable infection resulted in a 1.77 decrease in relative preference. There were gender differences, and where video was used, preferences were stronger., Conclusions: Strongest preferences were for attributes of functionality and independence versus connectedness and sensation but showed willingness to make risk-benefit trade-offs. Findings provide valuable information for regulatory benefit-risk decisions for prosthetic device innovations., Trial Registration: This study is not a clinical trial reporting results of a health care intervention so is not registered., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.)
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- 2023
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