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147 results on '"Dinc, Nazife"'

17. Functional Outcomes in Conservatively vs Surgically Treated Cerebellar Infarcts.

Author

Won, Sae-Yeon, Hernández-Durán, Silvia, Behmanesh, Bedjan, Bernstock, Joshua D., Czabanka, Marcus, Dinc, Nazife, Dubinski, Daniel, Freiman, Thomas M., Günther, Albrecht, Hellmuth, Kara, Herrmann, Eva, Konczalla, Juergen, Maier, Ilko, Melkonian, Ruzanna, Mielke, Dorothee, Naser, Paul, Rohde, Veit, Senft, Christian, Storch, Alexander, and Unterberg, Andreas

Published
2024
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18. Necrosectomy Versus Stand-Alone Suboccipital Decompressive Craniectomy for the Management of Space-Occupying Cerebellar Infarctions—A Retrospective Multicenter Study.

Author

Hernandez-Duran, Silvia, Walter, Johannes, Behmanesh, Bedjan, Bernstock, Joshua D., Czabanka, Marcus, Dinc, Nazife, Dubinski, Daniel, Freiman, Thomas M., Günther, Albrecht, Hellmuth, Kara, Herrmann, Eva, Konczalla, Juergen, Maier, Ilko, Melkonian, Ruzanna, Mielke, Dorothee, Müller, Sebastian Johannes, Naser, Paul, Rohde, Veit, Schaefer, Jan Hendrik, and Senft, Christian

Published
2024
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24. Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness.

Author

Dubinski, Daniel, Won, Sae-Yeon, Meyer-Wilmes, Jonas, Trnovec, Svorad, Rafaelian, Artem, Behmanesh, Bedjan, Cantré, Daniel, Baumgarten, Peter, Dinc, Nazife, Konczalla, Juergen, Wittstock, Matthias, Bernstock, Joshua D., Freiman, Thomas M., and Gessler, Florian

Subjects
BRAIN injuries, FRAILTY, INTRACRANIAL hemorrhage, COMPUTED tomography
Abstract

Background: Temporal muscle thickness (TMT) on cranial CT scans has recently been identified as a prognostic imaging parameter for assessing a patient's baseline frailty. Here, we analyzed whether TMT correlates with Traumatic brain injury (TBI) severity and whether it can be used to predict outcome(s) after TBI. Methods: We analyzed the radiological and clinical data sets of 193 patients with TBI who were admitted to our institution and correlated the radiological data with clinical outcomes after stratification for TMT. Results: Our analyses showed a significant association between high TMT and increased risk for intracranial hemorrhage (p = 0.0135) but improved mRS at 6 months (p = 0.001) as compared to patients with low TMT. Congruent with such findings, a lower TMT was associated with falls and reduced outcomes at 6 months (p < 0.0001 and p < 0.0001). Conclusion: High TMT was robustly associated with head trauma sequelae but was also associated with good clinical outcomes in TBI patients. These findings consolidate the significance of TMT as an objective marker of frailty in TBI patients; such measurements may ultimately be leveraged as prognostic indicators. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Frailty in cerebellar ischemic stroke--The significance of temporal muscle thickness.

Author

Dubinski, Daniel, Sae-Yeon Won, Mattes, Isabell, Trnovec, Svorad, Behmanesh, Bedjan, Cantré, Daniel, Baumgarten, Peter, Dinc, Nazife, Konczalla, Juergen, Wittstock, Matthias, Freiman, Thomas M., and Gessler, Florian

Subjects
ISCHEMIC stroke, STROKE, FRAILTY, PROGNOSIS
Abstract

While comprising only 2% of all ischemic strokes, cerebellar strokes are responsible for substantial morbidity and mortality due to their subtle initial presentation and the morbidity of posterior fossa swelling. Furthermore, low temporal muscle thickness (TMT) has recently been identified as a prognostic imaging parameter to assess patient frailty and outcome. We analyzed radiological and clinical data sets of 282 patients with cerebellar ischemic stroke. Our analysis showed a significant association between low TMT, reduced NIHSS and mRS at discharge (p = 0.035, p = 0.004), and reduced mRS at 12 months (p = 0.001). TMT may be used as a prognostic imaging marker and objective tool to assess outcomes in patients with cerebellar ischemic stroke. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Blood Clots May Compromise Intracranial Pressure Measurement Using Air-Pouch Intracranial Pressure Probes.

Author

Won, Sae-Yeon, Herrmann, Sascha, Dubinski, Daniel, Behmanesh, Bedjan, Trnovec, Svorad, Dinc, Nazife, Bernstock, Joshua D., Freiman, Thomas M., and Gessler, Florian A.

Subjects
THROMBOSIS, INTRACRANIAL pressure, PRESSURE measurement, INTRACEREBRAL hematoma, BASAL ganglia
Abstract

Background: Air-pouch balloon-assisted probes have proven to be both simple and reliable tools for intracranial pressure (ICP) monitoring. However, we experienced reproducible falsely high ICP measurements when the ICP probe was inserted into the intracerebral hematoma cavity. Thus, the aim of the experimental and translational study was to analyze the influence of ICP probe placement with regard to measured ICP values. Methods: Two Spiegelberg 3PN sensors were simultaneously inserted into a closed drain system and were connected to two separate ICP monitors thereby allowing for simultaneous ICP measurements. This closed system was also engineered to allow for pressure to be gradually increased in a controlled fashion. Once the pressure was verified using two identical ICP probes, one of the probes was coated with blood in an effort to replicate placement within an intraparenchymal hematoma. Pressures recorded using the coated probe and control probe were then recorded and compared across a range of 0–60 mmHg. In an effort to further the translational relevance of our results, two ICP probes were inserted in a patient that presented with a large basal ganglia hemorrhage that met criteria for ICP monitoring. One probe was inserted into the hematoma and the other into brain parenchyma; ICP values were recorded from both probes and the results compared. Results: The experimental set-up demonstrated a reliable correlation between both control ICP probes. Interestingly, the ICP probe covered with clot displayed a significantly higher average ICP value when compared to the control probe between 0 mmHg and 50 mmHg (p < 0.001); at 60 mmHg, there was no significant difference noted. Critically, this trend in discordance was even more pronounced in the clinical setting with the ICP probe placed within the hematoma cavity having reported significantly higher ICP values as compared to the probe within brain parenchyma. Conclusions: Our experimental study and clinical pilot highlight a potential pitfall in ICP measurement that may result secondary to probe placement within hematoma. Such aberrant results may lead to inappropriate interventions in an effort to address falsely elevated ICPs. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Reappraisal of Intracerebral Hemorrhages and Intracerebral Hemorrhage Grading Scale Score in Surgically and Medically Managed Cerebellar Intracerebral Hemorrhage.

Author

Won, Sae-Yeon, Walter, Johannes, Hernandez-Duran, Silvia, Alhalabi, Obada T., Behmanesh, Bedjan, Bernstock, Joshua D., Czabanka, Marcus, Dinc, Nazife, Dubinski, Daniel, Flüh, Charlotte, Freiman, Thomas M., Grosch, Anne S., Herrmann, Eva, Kang, Young Sill, Konczalla, Juergen, Kramer, Andreas, Lehmann, Felix, Lemcke, Johannes, Melkonian, Ruzanna, and Mielke, Dorothee

Published
2023
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31. Beeinflusst die Distanz zwischen Wohnort und neuroonkologischem Zentrum das Gesamtüberleben von Patienten mit Glioblastomen?

Author

Kamp, Marcel A., Bartholdt, Annett, Dinc, Nazife, von Sass, Christiane, Ernst, Thomas, and Senft, Christian A.

Subjects
ddc: 610, Medicine and health, neoplasms, nervous system diseases
Abstract

Objective: Glioblastomas are the most malignant astrocytoma with a significantly limited prognosis. Numerous prognostic markers, such as IDH mutation, MGMT promoter hypermethylation, general condition, and the form of operative and adjuvant therapy, were identified. There are also numerous additional [for full text, please go to the a.m. URL]

Published
2022

32. Risk and extent of intracranial haemorrhage in patients with COVID-19 infection admitted to intensive care unit

Author

Simion, George, Kamp, Marcel A., Senft, Christian A., and Dinc, Nazife

Subjects
Medicine and health
Abstract

Objective: The SARS-Cov2 pandemic has not yet been overcome even after 2 years. On the contrary, the number of corona patients is increasing and subsequently the number of patients with severe infection and neurosurgical-relevant complications. Intracranial bleeding is a dreaded concomitant complication. [for full text, please go to the a.m. URL]

Published
2022
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33. Die Bedeutung von ICH- und ICH-GS score bei chirurgisch und konservativ behandelter Kleinhirnblutung nach 20 Jahren

Author

Won, Sae-Yeon, Walter, Johannes, Hernández-Durán, Silvia, Dubinski, Daniel, Kramer, Andreas, Dinc, Nazife, Kang, Young-Sill, Lehmann, Felix, Grosch, Anna Sophie, Melkonian, Ruzanna, Behmanesh, Bedjan, Müller, Lukas, Turgut, Merih Öznur, Ullmann, Joana, Herrmann, Eva, Senft, Christian A., Mielke, Dorothee, Schneider, Matthias, Vatter, Hartmut, Konczalla, Jürgen, Czabanka, Marcus, Lemcke, Johannes, Alhalabi, Obada T., Zweckberger, Klaus, Ringel, Florian, Synowitz, Michael, Flüh, Charlotte, Rohde, Veit, Freiman, Thomas M., Schuss, Patrick, Kilinc, Fatma, and Geßler, Florian

Subjects
ddc: 610, Medicine and health, cardiovascular diseases, nervous system diseases
Abstract

Objective: Outcome prognostication represents a crucial step during acute care of intracerebral hemorrhage (ICH). Cerebellar hemorrhage represents the minority of ICH, requiring special considerations in this posterior fossa pathology. The aim of this study was to validate ICH- and ICH-GS score in patients [for full text, please go to the a.m. URL]

Published
2022

34. Glioblastoma tumour volumes in times of COVID-19 – a single centre analysis

Author

Karamani, Lydia, Kamp, Marcel A., Dinc, Nazife, and Senft, Christian A.

Subjects
Medicine and health
Abstract

Objective: COVID-19 is a highly contagious infectious disease caused by the SARS-CoV2 virus. Since its outbreak in December 2019 starting in Wuhan/China, it has caused a global pandemic. As part of the measures undertaken to tackle COViD-19 effects in Germany, in- and outpatient treatment has been [for full text, please go to the a.m. URL]

Published
2022
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36. Microsurgical treatment and follow-up of KOOS grade IV vestibular schwannoma: therapeutic concept and future perspective

Author

Won, Sae-Yeon, Kilian, Andreas, Dubinski, Daniel, Gessler, Florian, Dinc, Nazife, Lauer, Monika, Wolff, Robert, Freiman, Thomas, Senft, Christian, Konczalla, Juergen, Forster, Marie-Therese, and Seifert, Volker

Subjects
facial nerve functional outcome, Oncology, vestibular schwannoma, otorhinolaryngologic diseases, ddc:610, microsurgical treatment, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hearing nerve, lcsh:RC254-282, Original Research, KOOS IV
Abstract

Purpose: Surgery of KOOS IV vestibular schwannoma remains challenging regarding the balance of extent of tumor resection (EoR) and functional outcome. Our aim was to evaluate the outcome of surgical resection and define a cut-off value for safe resection with low risk for tumor regrowth of KOOS IV vestibular schwannoma. Methods: All patients presenting at the authors’ institution between 2000 and 2019 with surgically treated KOOS IV vestibular schwannoma were included. Outcome measures included EoR, facial/hearing nerve function, surgical complications and progression of residual tumor during the median follow-up period of 28 months. Results: In 58 patients, mean tumor volume was 17.1 ± 9.2 cm3, and mean EoR of 81.6 ± 16.8% could be achieved. Fifty-one patients were available for the follow-up analysis. Growth of residual tumor was observed in 11 patients (21.6%) followed by adjuvant treatment with stereotactic radiosurgery or repeat surgery in 15 patients (29.4%). Overall serviceable hearing preservation was achieved in 38 patients (74.5%) and good facial outcome at discharge was observed in 66.7% of patients, significantly increasing to 82.4% at follow-up. Independent predictors for residual tumor growth was EoR ≤ 87% (OR11.1) with a higher EoR being associated with a very low number of residual tumor progression amounting to 7.1% at follow-up (p=0.008). Conclusions: Subtotal tumor resection is a good therapeutic concept in patients with KOOS IV vestibular schwannoma resulting in a high rate of good hearing and facial nerve function and a very low rate of subsequent tumor progression. The goal of surgery should be to achieve more than 87% of tumor resection to keep residual tumor progression low.

Published
2020

37. Einfluss der zuführenden Arterien auf das Blutungsrisiko von zerebralen arteriovenösen Malformationen

Author

Eibach, Michael, Won, Sae-Yeon, Quick-Weller, Johanna, Berkefeld, Joachim, Konczalla, Jürgen, Herrmann, Eva, Seifert, Volker, Marquardt, Gerhard, and Dinc, Nazife

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Angioarchitectur and hemodynamic conditions play an important role in the hemorrhage risk in brain arteriovenous malformations. Knowledge of hemodynamics of blood flow is required for risk assessment and treatment options. The purpose of this study was to investigate whether the number or[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020

39. Validierung und Altersabhängigkeit des Subarachnoid Hemorrhage Early Brain Edema Scores (SEBES)

Author

Eibach, Michael, Won, Sae-Yeon, Kashefiolasl, Sepide, Dinc, Nazife, Bruder, Markus, Herrmann, Eva, Seifert, Volker, and Konczalla, Jürgen

Subjects
ddc: 610, cardiovascular diseases, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is associated with a poor prognosis. A key factor for EBI is cerebral edema. The Subarachnoid hemorrhage Early Brain Edema Score (SEBES) is a semiquantitative score to measure cerebral edema in cranial CT.1 Until now, only [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

40. Die Verwendung von Vasopressin als Zusatz zur Katecholamin-Therapie bei induzierter Hypertonie bei Subarachnoidalblutungen

Author

Dinc, Nazife, Won, Sae-Yeon, Eibach, Michael, Quick-Weller, Johanna, Bruder, Markus, Seifert, Volker, and Konczalla, Jürgen

Subjects
ddc: 610, cardiovascular diseases, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Blood pressure management in patients with severe subarachnoid hemorrhage (SAH) and refractory hypertensive therapy is demanding and may require the careful use of additional drugs to elevate mean arterial pressure (>110 mmHG) during cerebral vasospasm (CVS) time. The aim of the present[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

41. Unterschiedliche Blutungsmuster bei AVM-Blutungen und deren Auswirkung auf das Outcome - die Signifikanz zur Risikoeinschätzung

Author

Dinc, Nazife, Won, Sae-Yeon, Eibach, Michael, Quick-Weller, Johanna, Konczalla, Jürgen, Berkefeld, Joachim, Seifert, Volker, and Marquardt, Gerhard

Subjects
fluids and secretions, ddc: 610, 610 Medical sciences, Medicine, equipment and supplies
Abstract

Objective: Cerebral vasospasm (CVS) after a ruptured arteriovenous malformation (AVM) is rarely reported. The aim of the present study is to evaluate different bleeding patterns in AVM hemorrhage and the incidence of CVS for risk and treatment stratification. Methods: We evaluated 160 patients [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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42. AVM-Blutung bei schwangeren Patienten - Nutzen multizentrischer Datenbanken zur quantitativen Bewertung seltener Krankheiten und Behandlungsrichtlinien

Author

Dinc, Nazife, Quick-Weller, Johanna, Eibach, Michael, Marquardt, Gerhard, Seifert, Volker, and Konczalla, Jürgen

Subjects
genetic structures, ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Treatment of pregnant patients with AVM hemorrhage is challenging. However, data is also scarce. Because of the the rarity of this disease, standardized modalities in imaging and treatment algorithm are necessary in order to make individual treatment plans. The aim of the present study [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

43. Chirurgisches Outcome der breitbasigen Aneurysmen, Part 1 - Rupturierte Aneurysmen

Author

Won, Sae-Yeon, Dubinski, Daniel, Dinc, Nazife, Brawanski, Nina, Seifert, Volker, Berkefeld, Joachim, and Konczalla, Jürgen

Subjects
ddc: 610, cardiovascular system, macromolecular substances, cardiovascular diseases, 610 Medical sciences, Medicine
Abstract

Objective: To clip or coil has been matter of debates for several years and is the domain of interdisciplinary decision making. Regarding wide neck aneurysm (WNA), there has been several studies presenting outcome of endovascular treatment, however, the surgical outcome has still been elusive. The aim[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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44. Differences in bleeding patterns and outcome after intracerebral hemorrhage due to vascular malformations

Author

Dinc, Nazife, Won, Sae-Yeon, Brawanski, Nina, Eibach, Michael, Quick-Weller, Johanna, Konczalla, Jürgen, Berkefeld, Joachim, Seifert, Volker, Marquardt, Gerhard, and Meckel, Stephan

Subjects
Male, Vascular Malformations, Cardiovascular Medicine, Pathology and Laboratory Medicine, Antiplatelet Therapy, Vascular Medicine, Neurosurgical Procedures, Diagnostic Radiology, Mathematical and Statistical Techniques, Medicine and Health Sciences, Prospective Studies, Cardiovascular Imaging, Aged, 80 and over, Hematoma, Pharmaceutics, Radiology and Imaging, Statistics, Angiography, Middle Aged, Magnetic Resonance Imaging, Physical Sciences, Medicine, Female, Research Article, Adult, Death Rates, Imaging Techniques, Science, Hemorrhage, Neuroimaging, Research and Analysis Methods, Young Adult, Signs and Symptoms, Drug Therapy, Population Metrics, Diagnostic Medicine, Humans, ddc:610, Statistical Methods, Aged, Cerebral Hemorrhage, Retrospective Studies, Population Biology, Biology and Life Sciences, ROC Curve, Multivariate Analysis, Mathematics, Neuroscience
Abstract

Background: Atypical intracerebral hemorrhage is a common form of primary manifestation of vascular malformations. Objective: The aim of the present study is to determine clues to the cause of bleeding according to hemorrhage pattern (lobar, basal ganglia, infratentorial). Methods: We retrospectively evaluated 343 consecutive neurosurgical patients with intracerebral hemorrhage (ICH), who were admitted to our neurosurgical department between 2006 and 2016. The study cohort includes only neurosurgical patients. Patients who underwent treatment by neurologists are not represented in this study. We assessed location of hemorrhage, hematoma volumes to rule out differences and predicitve variables for final outcome. Results: In 171 cases (49.9%) vascular malformations, such as arteriovenous malformations (AVMs), cavernomas, dural fistulas and aneurysms were the cause of bleeding. 172 (50.1%) patients suffered from an intracerebral hemorrhage due to amyloid angiopathy or long standing hypertension. In patients with infratentorial hemorrhage a malformation was more frequently detected as in patients with supratentorial hemorrhage (36% vs. 16%, OR 2.9 [1.8;4.9], p

Published
2019

47. Vasospasm of the basilar artery following aneurysmal SAH - clinical observations and implications for experimental research

Author

Dinc, Nazife, Tritt, Stephanie, Quick-Weller, Johanna, Konczalla, Jürgen, Mersmann, Jan, Seifert, Volker, and Senft, Christian

Subjects
fluids and secretions, ddc: 610, cardiovascular system, sense organs, 610 Medical sciences, Medicine, equipment and supplies
Abstract

Objective: The basilar artery is frequently used as reference vessel for laboratory investigations of cerebral vasospasm (CVS) in many experimental models. However, it is unclear whether this artery is representative in regards to the clinical manifestations and sequelae of basilar artery CVS in humans[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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48. Stereotactic biopsy in old and very old patients

Author

Quick, Johanna, Won, Sae-Yeon, Dinc, Nazife, Behmanesh, Bedjan, Seifert, Volker, and Marquardt, Gerhard

Subjects
ddc: 610, 610 Medical sciences, Medicine, humanities
Abstract

Objective: Stereotactic biopsy is an everyday procedure among various neurosurgical departments. The procedure is performed to obtain tumor tissue of unknown origin. Going in hand with low complication rates and high diagnostic yield, stereotactic biopsies can be performed in adults and children, too,[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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49. Follow-Up imaging after clipping of ruptured aneurysms: what happens with the neck remnants?

Author

Konczalla, Jürgen, Gessler, Florian, Won, Sae-Yeon, Dinc, Nazife, Bruder, Markus, Tritt, Stephanie, and Seifert, Volker

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Whereas data of follow-up imaging after endovascular procedures is widely available, data after microsurgical clipping is rare. Nowadays, due to improved techniques in in neuro-imaging (e.g. 3D angiography), neck remnants are identified more often. Therefore, we analyzed our patients who [for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017

50. Diagnostic accuracy of spontaneous intracerebral hemorrhage. Are there predictive factors for bleeding origins?

Author

Dinc, Nazife, Won, Sae-Yon, Brawanski, Nina, Quick-Weller, Johanna, Konczalla, Jürgen, Seifert, Volker, and Marquardt, Gerhard

Subjects
body regions, ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Atypical intracerebral hemorrhage is a common form of primary manifestation of vascular malformations. Hematoma location (lobar, brain stem, cerebellar) can give a clue to the cause of the bleeding. Methods: We retrospectively evaluated 279 consecutive patients with spontaneous intracerebral[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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