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478 results on '"Dias, Joao"'

11. Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system

Author

Badja, Cherif, Momen, Sophie, Koh, Gene Ching Chiek, Boushaki, Soraya, Roumeliotis, Theodoros I., Kozik, Zuza, Jones, Ian, Bousgouni, Vicky, Dias, João M.L., Krokidis, Marios G., Young, Jamie, Chen, Hongwei, Yang, Ming, Docquier, France, Memari, Yasin, Valcarcel-Zimenez, Lorea, Gupta, Komal, Kong, Li Ren, Fawcett, Heather, Robert, Florian, Zhao, Salome, Degasperi, Andrea, Kumar, Yogesh, Davies, Helen, Harris, Rebecca, Frezza, Christian, Chatgilialoglu, Chryssostomos, Sarkany, Robert, Lehmann, Alan, Bakal, Chris, Choudhary, Jyoti, Fassihi, Hiva, and Nik-Zainal, Serena

Published
2024
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30. Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

Author

Coelho dos Reis, Jordana Grazziela A., Ferreira, Geovane Marques, Lourenço, Alice Aparecida, Ribeiro, Ágata Lopes, da Mata, Camila Pacheco da Silveira Martins, de Melo Oliveira, Patrícia, Marques, Daisymara Priscila de Almeida, Ferreira, Linziane Lopes, Clarindo, Felipe Alves, da Silva, Murillo Ferreira, Filho, Heitor Portella Póvoas, Oliveira, Nilson Roberto Ribeiro, Jr, Sodré, Maisah Meyhr D’Carmo, Gadelha, Sandra Rocha, Albuquerque, George Rego, Maciel, Bianca Mendes, Mariano, Ana Paula Melo, Silva, Mylene de Melo, Fontana, Renato, Marin, Lauro Juliano, Carlos, Renata Santiago Alberto, Lopes, Amanda Teixeira Sampaio, Ferreira, Fabrício Barbosa, dos Santos, Uener Ribeiro, Santana, Íris Terezinha Santos de, Fehlberg, Hllytchaikra Ferraz, Rezende, Rachel Passos, Dias, João Carlos T., Gross, Eduardo, Goulart, Gisele Assis Castro, Santiago, Marie Gabriele, de Lemos, Ana Paula Motta Lavigne, da Conceição, Aline O., Romano, Carla Cristina, de Carvalho, Luciana Debortoli, Filho, Olindo Assis Martins, Quadros, Claudio Almeida, Morris, David L., and Valle, Sarah J.

Published
2022
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35. From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

Author

Brown, Alastair J.H., Bradley, Sophie J., Marshall, Fiona H., Brown, Giles A., Bennett, Kirstie A., Brown, Jason, Cansfield, Julie E., Cross, David M., de Graaf, Chris, Hudson, Brian D., Dwomoh, Louis, Dias, João M., Errey, James C., Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J., Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C., Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M., Goonawardena, Anushka V., Morairty, Stephen R., Browning, Michael, Perini, Francesca, Dawson, Gerard R., Deakin, John F.W., Smith, Robert T., Sexton, Patrick M., Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G., Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J., Jazayeri, Ali, Cooke, Robert M., Rucktooa, Prakash, Congreve, Miles S., Weir, Malcolm, and Tobin, Andrew B.

Published
2021
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46. Viscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta‐analysis.

Author

Dias, Joao D., Levy, Jerrold H., Tanaka, Kenichi A., Zacharowski, Kai, and Hartmann, Jan

Subjects
*RED blood cell transfusion, *PLASMA products, *ELECTIVE surgery, *BLOOD transfusion, *RANDOMIZED controlled trials, *BLOOD platelet transfusion
Abstract

Summary: Background: Patients undergoing major surgery frequently experience major uncontrolled bleeding. The aim of this systematic review and meta‐analysis was to evaluate the clinical efficacy of using viscoelastic haemostatic assays to manage peri‐operative bleeding in elective surgery. Methods: We searched PubMed/MEDLINE and Embase databases for randomised controlled trials according to pre‐determined criteria. The primary outcomes were blood product requirements; duration of stay in the operating theatre or ICU; and surgical reintervention rate. Results: We included 20 randomised controlled trials. The overall risk of bias was low to moderate. Twelve studies used thromboelastography‐based transfusion algorithms, while eight used thromboelastometry. Viscoelastic haemostatic assay‐guided therapy was associated with a statistically significant reduction in transfusion of red blood cells (standardised mean difference (95%CI) 0.16 (‐0.29 to 0.02)), platelets (standardised mean difference (95%CI) ‐0.33 (‐0.56 to ‐0.10)) and fresh frozen plasma (standardised mean difference (95%CI) ‐0.64 (‐1.01 to ‐0.28)). There was no evidence of an effect of viscoelastic haemostatic assay‐guided therapy on surgical reintervention (relative risk (95%CI) 1.09 (0.70–1.69)). Viscoelastic haemostatic assay‐guided therapy was associated with lower blood loss and shorter ICU duration of stay. There was no evidence of any effect on total duration of stay and all‐cause mortality. Conclusions: Viscoelastic haemostatic assay‐guided therapy may reduce peri‐operative blood product transfusion requirements and blood loss during major elective surgery, with no discernible effect on patient‐centred outcomes. The overall quality of evidence was modest. [ABSTRACT FROM AUTHOR]

Published
2025
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48. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Author

Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S., Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G., Webster, Natalie A., Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M. L., Bannister, Andrew J., Vick, Binje, Jeremias, Irmela, Vassiliou, George S., Rausch, Oliver, Tzelepis, Konstantinos, and Kouzarides, Tony

Published
2021
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49. Designing a Mood-Mediated Multi-Level Reasoner.

Author

Gomes, Samuel, Rocha, Jose Bernardo, Dias, Joao, and Martinho, Carlos

Abstract

Psychology-oriented research extensively studied how affect influences human decision making. Particularly, the cognitive tuning assumption suggests that mood can serve to regulate between shallow and deliberative decisions – a more negative mood means higher deliberation. This work proposes a model that mimics the cognitive tuning assumption. To that end, the Collective Risk Dilemma (CRD) game For the Planet was designed and created, a process allowing for distinct levels of reasoning was defined and tested in that game, and mood was integrated to control the level of reasoning of such a process. Several distinct Artificial Intelligence (AI) profiles were created to verify that the developed model was able to dynamically change the level of reasoning and adjust the resulting AI behavior in our CRD game. Results revealed that the distinct AI profiles were influenced by their affective states and experienced circumstances, and that the emergent behaviors were consistent with the cognitive tuning assumption, thus demonstrating that we managed to construct an innovative and flexible model that can use mood to dynamically adjust the level of reasoning of an AI agent. [ABSTRACT FROM AUTHOR]

Published
2024
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