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4. The RIBES strategy for ex situ conservation: conventional and modern techniques for seed conservation

Author

Magrini S., Bonomi C., Bacchetta G., Bedini G., Borzatti A., Boscutti F., Carasso V., Carta A., Casavecchia S., Casolo V., Ceriani R., Cristaudo A., Di Cecco V., Di Martino L., Digangi I., Fabrini G., Guglielmo F., Mariotti M., Negri V., Porceddu M., Villani M., Zappa E., Salmeri C., Magrini S., Bonomi C., Bacchetta G., Bedini G., Borzatti A., Boscutti F., Carasso V., Carta A., Casavecchia S., Casolo V., Ceriani R., Cristaudo A., Di Cecco V., Di Martino L., Digangi I., Fabrini G., Guglielmo F., Mariotti M., Negri V., Porceddu M., Villani M., Zappa E., and Salmeri C.

Subjects
conservation strategy, seed/spore research, Settore BIO/02 - Botanica Sistematica, Settore BIO/03 - Botanica Ambientale E Applicata, Italian flora, Plant Science, priority lists, seed banks
Abstract

The Italian seed bank network (RIBES) aims to improve the quality and safety of the germplasm reserves of native plant species in Italy to ensure the long-term conservation of endangered and/or endemic flora. The strategy includes traditional methods to secure seed conservation. A comprehensive priority list for seed collection is being defined, it was prepared by crossing data of various checklists (red lists, endemics) and will soon be cross-referenced with an updated list of accessions of the whole network. A safety-backup program of duplicates will quickly be implemented to secure the conservation of the most threatened species in at least two seed banks of the network. On the other hand, the RIBES strategy also includes research by applying modern techniques. In collaboration with the Millennium Seed Bank, research on the storage behaviour of seeds and spores through thermal analysis is ongoing to inform conservation. Using the Differential Scanning Calorimetry (DSC), we could evaluate seed lipid properties such as glass transition temperature, melting, crystallization, oxidation behaviour, and thermal stability. Finally, RIBES participates as a co-funder in the LIFE Nature project SEEDFORCE, coordinating 11 seed banks of the network for collecting seeds/spores of 29 threatened species of EU interest.

Published
2022

10. Plant functional traits and the environment: a review of Italian studies

Author

CHELLI S, MARIGNANI M, BARNI E, PETRAGLIA A, PUGLIELLI G, WELLSTEIN C, ACOSTA ATR, BOLPAGNI R, BRAGAZZA L, CAMPETELLA G, CHIARUCCI A, CONTI L, NASCIMBENE J, ORSENIGO S, PIERCE S, RICOTTA C, TARDELLA FM, ABELI T, ARONNE G, BACARO G, BAGELLA S, BENESPERI R, BERNAREGGI G, BONANOMI G, BRUSA G, BUFFA G, BURRASCANO S, CACCIANIGA M, CALABRESE V, CANULLO R, CARBOGNANI M, CARBONI M, CARRANZA ML, CATORCI A, CICCARELLI D, CITTERIO S, CUTINI M, DALLE FRATTE M, DE MICCO V, DEL VECCHIO S, DI MARTINO L, DI MUSCIANO M, FANTINATO E, FILIGHEDDU R, FRATTAROLI A, GENTILI R, GERDOL R, GIARRIZZO E, GIORDANI P, GRATANI L, INCERTI G, MAZZOLENI S, MONDONI A, MONTAGNANI C, MONTAGNOLI AA, PAURA B, PETRUZZELLIS F, PISANU S, ROSSI G, SGARBI E, SINISCALCO C, SLAVIERO A, STANISCI A, STINCA A, TOMASELLI M & CERABOLINI BEL, Chelli, S, Marignani, M, Barni, E, Petraglia, A, Puglielli, G, Wellstein, C, Acosta, Atr, Bolpagni, R, Bragazza, L, Campetella, G, Chiarucci, A, Conti, L, Nascimbene, J, Orsenigo, S, Pierce, S, Ricotta, C, Tardella, Fm, Abeli, T, Aronne, G, Bacaro, G, Bagella, S, Benesperi, R, Bernareggi, G, Bonanomi, G, Brusa, G, Buffa, G, Burrascano, S, Caccianiga, M, Calabrese, V, Canullo, R, Carbognani, M, Carboni, M, Carranza, Ml, Catorci, A, Ciccarelli, D, Citterio, S, Cutini, M, DALLE FRATTE, M, DE MICCO, V, DEL VECCHIO, S, DI MARTINO, L, DI MUSCIANO, M, Fantinato, E, Filigheddu, R, Frattaroli, A, Gentili, R, Gerdol, R, Giarrizzo, E, Giordani, P, Gratani, L, Incerti, G, Mazzoleni, S, Mondoni, A, Montagnani, C, Montagnoli, Aa, Paura, B, Petruzzellis, F, Pisanu, S, Rossi, G, Sgarbi, E, Siniscalco, C, Slaviero, A, Stanisci, A, Stinca, A, Tomaselli, M &amp, and CERABOLINI BEL

Subjects
land use change, terrestrial and freshwater environments, CSR plant strategy theory, plant trait, forest management, Climate change, intraspecific variability
Abstract

Italy is among the European countries with the greatest plant diversity due to both a great environmental heterogeneity and a long history of man–environment interactions. Trait-based approaches to ecological studies have developed greatly over recent decades worldwide, although several issues concerning the relationships between plant functional traits and the environment still lack sufficient empirical evaluation. To draw insights on the association between plant functional traits and direct and indirect human and natural pressures on the environmental drivers, this article summarizes the existing knowledge on this topic by reviewing the results of studies performed in Italy adopting a functional trait approach on vascular plants, bryophytes and lichens. Although we recorded trait measurements for 1418 taxa, our review highlighted some major gaps in plant traits knowledge: Mediterranean ecosystems are poorly represented; traits related to belowground organs are still overlooked; traits measurements for bryophytes and lichens are lacking. Finally, intraspecific variation has been little studied at community level so far. We conclude by highlighting the need for approaches evaluating trait–environment relationship at large spatial and temporal scales and the need of a more effective contribution to online databases to tie more firmly Italian researchers to international scientific networks on plant traits.

Published
2019

12. The RIBES strategy for ex situ conservation: conventional and modern techniques for seed conservation.

Author

Magrini, S., Bonomi, C., Bacchetta, G., Bedini, G., Borzatti, A., Boscutti, F., Carasso, V., Carta, A., Casavecchia, S., Casolo, V., Ceriani, R., Cristaudo, A., Di Cecco, V., Di Martino, L., Digangi, I., Fabrini, G., Guglielmo, F., Mariotti, M., Negri, V., and Porceddu, M.

Subjects
GLASS transition temperature, SEED harvesting, NATIVE plants, ENDANGERED plants, DIFFERENTIAL scanning calorimetry, ENDANGERED species, SEEDS
Abstract

The Italian seed bank network (RIBES) aims to improve the quality and safety of the germplasm reserves of native plant species in Italy to ensure the long-term conservation of endangered and/or endemic flora. The strategy includes traditional methods to secure seed conservation. A comprehensive priority list for seed collection is being defined, it was prepared by crossing data of various checklists (red lists, endemics) and will soon be cross-referenced with an updated list of accessions of the whole network. A safety-backup program of duplicates will quickly be implemented to secure the conservation of the most threatened species in at least two seed banks of the network. On the other hand, the RIBES strategy also includes research by applying modern techniques. In collaboration with the Millennium Seed Bank, research on the storage behaviour of seeds and spores through thermal analysis is ongoing to inform conservation. Using the Differential Scanning Calorimetry (DSC), we could evaluate seed lipid properties such as glass transition temperature, melting, crystallization, oxidation behaviour, and thermal stability. Finally, RIBES participates as a co-funder in the LIFE Nature project SEEDFORCE, coordinating 11 seed banks of the network for collecting seeds/spores of 29 threatened species of EU interest. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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16. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis

Author

Menghini, P, Di Martino, L, Lopetuso, LR, Corridoni, D, Webster, JC, Xin, W, Arseneau, KO, Lam, M, Pizarro, TT, Cominelli, F, Han, X, and Han, X

Subjects
0301 basic medicine, Carcinogenesis, Colorectal cancer, Cancer Treatment, lcsh:Medicine, Pathology and Laboratory Medicine, Inflammatory bowel disease, Mice, chemistry.chemical_compound, Crohn Disease, Medicine and Health Sciences, Ileitis, lcsh:Science, Immune Response, Crohn's disease, Multidisciplinary, Nuclear Proteins, Animal Models, Colitis, 3. Good health, Experimental Organism Systems, Oncology, Colonic Neoplasms, Anatomy, Research Article, Dysplasia, Colon, Immunology, Mouse Models, Surgical and Invasive Medical Procedures, Gastroenterology and Hepatology, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Signs and Symptoms, Diagnostic Medicine, medicine, Genetic predisposition, Animals, Inflammation, business.industry, Azoxymethane, lcsh:R, Inflammatory Bowel Disease, Membrane Proteins, Biology and Life Sciences, Cancer, Endoscopy, medicine.disease, digestive system diseases, Gastrointestinal Tract, Disease Models, Animal, 030104 developmental biology, chemistry, lcsh:Q, business, Digestive System
Abstract

Patients with inflammatory bowel disease (IBD) are at increased risk for developing colorectal cancer. Evidence suggests that colonic dysplasia and colitis-associated cancer (CAC) are often linked to repeated cycles of epithelial cell injury and repair in the context of chronic production of inflammatory cytokines. Several mouse models of CAC have been proposed, including chemical induction through exposure to dextran sulfate sodium (DSS) with the genotoxic agents azoxymethane (AOM), 1,2-dymethylhydrazine (DHM) or targeted genetic mutations. However, such models are usually performed on healthy animals that usually lack the underlying genetic predisposition, immunological dysfunction and dysbiosis characteristic of IBD. We have previously shown that inbred SAMP1/YitFc (SAMP) mice develop a progressive Crohn's disease (CD)-like ileitis in the absence of spontaneous colitis. We hypothesize that SAMP mice may be more susceptible to colonic tumorigenesis due to their predisposition to IBD. To test this hypothesis, we administered AOM/DSS to IBD-prone SAMP and their non-inflamed parental control strain, AKR mice. Our results showed that AOM/DSS treatment enhanced the susceptibility of colitis in SAMP compared to AKR mice, as assessed by endoscopic and histologic inflammatory scores, daily weight loss and disease activity index (DAI), during and after DSS administration. SAMP mice also showed increased colonic tumorigenesis, resulting in the occurrence of intramucosal carcinoma and a higher incidence of high-grade dysplasia and tumor burden. These phenomena occurred even in the absence of AOM and only upon repeated cycles of DSS. Taken together, our data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis. This novel model represents a useful tool to investigate relevant mechanisms of CAC, as well as for pre-clinical testing of potential IBD and colon cancer therapeutics.

Published
2018

18. Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials

Author

Alberro, JA, Ballester, B, Deulofeu, P, Fabregas, R, Fraile, M, Gubern, JM, Janer, J, Moral, A, de Pablo, JL, Penalva, G, Puig, P, Ramos, M, Rojo, R, Santesteban, P, Serra, C, Sola, M, Solarnau, L, Solsona, J, Veloso, E, Vidal, S, Abe, O, Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Ohashi, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Coles, CE, Haybittle, JL, Moebus, V, Leonard, CF, Calais, G, Garaud, P, Collett, V, Davies, C, Delmestri, A, Sayer, J, Harvey, VJ, Holdaway, IM, Kay, RG, Mason, BH, Forbe, JF, Franci, PA, Wilcken, N, Balic, M, Bartsch, R, Fesl, C, Fitzal, F, Fohler, H, Gnant, M, Greil, R, Jakesz, R, Marth, C, Mlineritsch, B, Pfeiler, G, Singer, CF, Steger, GG, Stoeger, H, Canney, P, Yosef, HMA, Focan, C, Peek, U, Oates, GD, Powell, J, Durand, M, Mauriac, L, Di Leo, A, Dolci, S, Larsimont, D, Nogaret, JM, Philippson, C, Piccart, MJ, Masood, MB, Parker, D, Price, JJ, Lindsay, MA, Mackey, J, Martin, M, Hupperets, PSGJ, Bates, T, Blamey, RW, Chetty, U, Ellis, IO, Mallon, E, Morgan, DAL, Patnick, J, Pinder, S, Lohrisch, C, Nichol, A, Bartlett, JMS, Bramwell, VH, Chen, BE, Chia, SKL, Gelmon, K, Goss, PE, Levine, MN, Parulekar, W, Pater, JL, Pritchard, KI, Shepherd, LE, Tu, D, Whelan, T, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Norton, L, Weiss, RB, Abu-Zahara, HT, Karpov, A, Portnoj, SL, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett-Lee, PJ, Manse, RE, Monypenny, IJ, Gordon, NH, Davis, HL, Cuzick, J, Sestak, I, Lehingue, Y, Romestaing, P, Dubois, JB, Delozier, T, Griffon, B, Lesec'h, J Mace, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, JR, Meier, P, Shan, Y, Shao, YF, Wang, X, Zhao, DB, Howell, A, Swindell, R, Albano, J, de Oliveira, CF, Gervasio, H, Gordilho, J, Ejlertsen, B, Jensen, M-B, Mouridsen, H, Gelman, RS, Harris, JR, Hayes, D, Henderson, C, Shapiro, CL, Christiansen, P, Ewertz, M, Jensen, MB, Mouridsen, HT, Fehm, T, Trampisch, HJ, Dalesio, O, de Vries, EGE, Rodenhuis, S, van Tinteren, H, Comis, RL, Davidson, NE, Gray, R, Robert, N, Sledge, G, Solin, LJ, Sparano, JA, Tormey, DC, Wood, W, Cameron, D, Dixon, JM, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, JGM, Treurniet-Donker, AD, van Putten, WLJ, Rotmensz, N, Veronesi, U, Viale, G, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, JP, Poortmans, PM, Rutgers, E, van de Velde, CJH, Cunningham, MP, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, LJ, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Lupors, E, Namer, M, Carrasco, E, Segui, MA, Eierman, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, JU, Costa, SD, Eidtmann, H, Gerber, B, Jackisch, C, Loib, S, von Minckwitz, G, de Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, MC, Sacco, M, Valentini, M, McArdle, CS, Smith, DC, Stallard, S, Dent, DM, Gudgeon, CA, Hacking, A, Murray, E, Panieri, E, Werner, ID, De Salvo, GL, Del Bianco, P, Zavagno, G, Leone, B, Vallejo, CT, Zwenger, A, Galligioni, E, Lopez, M, Erazo, A, Medina, JY, Horiguchi, J, Takei, H, Fentiman, IS, Hayward, JL, Rubens, RD, Skilton, D, Scheurlen, H, Sohn, HC, Untch, M, Dafni, U, Markopoulos, C, Bamia, C, Fountzilas, G, Koliou, G-A, Manousou, K, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Canavese, G, Tinterri, C, Margreiter, R, de Lafontan, B, Mihura, J, Roche, H, Asselain, B, Salmon, RJ, Vilcoq, JR, Brain, E, de La Lande, B, Mouret-Fourme, E, Andre, F, Arriagada, R, Delaloge, S, Hill, C, Koscienly, S, Michiels, S, Rubino, C, A'Hern, R, Bliss, J, Ellis, P, Kilburn, L, Yarnold, JR, Benraadt, J, Kooi, M, van de Velde, AO, van Dongen, JA, Vermorken, JB, Castiglione, M, Coates, A, Colleoni, M, Collins, J, Forbes, J, Gelbe, RD, Goldhirsch, A, Lindtner, J, Price, KN, Regan, MM, Rudenstam, CM, Senn, HJ, Thuerlimann, B, Bliss, JM, Chilvers, CED, Coombes, RC, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Foster, L, George, WD, Stewart, HJ, Stroner, P, Borovik, R, Hayat, H, Inbar, MJ, Peretz, T, Robinson, E, Camerini, T, Formelli, F, Martelli, G, Di Mauro, MG, Perrone, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Musolino, A, Passalacqua, R, Iwata, H, Shien, T, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Sadoon, M, Tulusan, AH, Kohno, N, Miyashita, M, Takao, S, Ahn, J-H, Jung, KH, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, Liefers, GJ, Christiaens, R, Neven, P, Paridaens, R, Van den Bogaert, W, Gazet, JC, Corcoran, N, Deshpande, N, di Martino, L, Douglas, P, Host, H, Lindtner, A, Notter, G, Bryant, AJS, Ewing, GH, Firth, LA, Krushen-Kosloski, JL, Nissen-Meyer, R, Anderson, H, Killander, F, Malmstrom, P, Ryden, L, Arnesson, L-G, Carstense, J, Dufmats, M, Fohlin, H, Nordenskjold, B, Soderberg, M, Sundqvist, M, Carpenter, TJ, Murray, N, Royle, GT, Simmonds, PD, Albain, K, Barlow, W, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, CK, Ravdin, PM, Bergh, J, Bondesso, T, Celebiogl, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Goransson, E, Iiristo, M, Johansson, U, Lenner, E, Lofgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, af Trampe, E, Wadstrom, C, Janni, W, Maibach, R, Thurlimann, B, Hadji, P, Hozumi, J, Holli, K, Rouhento, K, Safra, T, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, AHG, Fyles, A, Meakin, JW, Panzarella, T, Bahi, J, Lemonnier, J, Martin, AL, Reid, M, Spittle, M, Bishop, H, Bundred, NJ, Forbes, JF, Forsyth, S, George, WS, Pinder, SE, Deutsch, GP, Kwong, DLW, Pai, VR, Peto, R, Senanayake, F, Boccardo, F, Rubagotti, A, Baum, M, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, JS, Carlomagno, C, De Laurentiis, M, De Placido, S, Schem, C, Williams, L, Bell, R, Coleman, RE, Dodwell, D, Hinsley, S, Marshall, HC, Pierce, LJ, Basso, SMM, Lumachi, F, Solomayer, E, Horsman, JM, Lester, J, Winter, MC, Buzdar, AU, Hsu, L, Love, RR, Ahlgren, J, Garmo, H, Holmberg, L, Lindman, H, Warnberg, F, Asmar, L, Jones, SE, Aft, R, Gluz, O, Harbeck, N, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, BK, Chlebowski, RT, Caffier, H, Brufsky, AM, Llombart, HA, Asselain, B, Barlow, W, Bartlett, J, Bradley, R, Braybrooke, J, Davies, C, Dodwell, D, Gray, R, Mannu, G, Taylor, C, Peto, R, McGale, P, Pan, H, Wang, Y, Wang, Z, Department of Oncology, Clinicum, HUS Comprehensive Cancer Center, Medical Oncology, Cancer Research UK, and Pfizer Limited

Subjects
0301 basic medicine, Oncology, Time Factors, SURGERY, medicine.medical_treatment, menopause, chemotherapy, Mastectomy, Segmental, Rate ratio, THERAPY, aromatase inhibitors, CEA, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Breast, Neoplasm Metastasis, Randomized Controlled Trials as Topic, RISK, tamoxifen, breast tumor, CA15-3, axillary dissection, mastectomy, Middle Aged, Neoadjuvant Therapy, METHOTREXATE, 3. Good health, trastuzumab, Treatment Outcome, quadrantectomy, Chemotherapy, Adjuvant, axillary lymphnodes, 030220 oncology & carcinogenesis, Meta-analysis, SURVIVAL, Disease Progression, Female, Life Sciences & Biomedicine, axillary clearance, RADIOTHERAPY, medicine.drug, Adult, medicine.medical_specialty, Anthracycline, 3122 Cancers, Antineoplastic Agents, Breast Neoplasms, axillary nodes, sentinel node biopsy, 03 medical and health sciences, breast cancer, Breast cancer, SDG 3 - Good Health and Well-being, HER2, Internal medicine, Journal Article, medicine, cancer, Humans, Breast, breast cancer, breast diseases, cancer, malignancy, menopause, surgery, mastectomy, quadrantectomy, lumpectomy, axillary nodes, axillary lymphnodes, axillary dissection, axillary clearance, sentinel node biopsy, sentinel node, BRCA1, BRCA2, tamoxifen, aromatase inhibitors, breast tumor, osteoporosis, bisphosphonates, denosumab, trastuzumab, HER2, CEA, CA15-3, tumor marker, chemotherapy, endocrine therapy, Oncology & Carcinogenesis, RECURRENCE, bisphosphonates, Pathological, Neoplasm Staging, lumpectomy, Chemotherapy, Science & Technology, breast diseases, endocrine therapy, business.industry, denosumab, BRCA1, medicine.disease, BRCA2, osteoporosis, Radiation therapy, STIMULATING FACTOR, 030104 developmental biology, sentinel node, tumor marker, Methotrexate, Neoplasm Recurrence, Local, business, 1112 Oncology And Carcinogenesis, malignancy
Abstract

BACKGROUND: Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. METHODS: We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality). FINDINGS: Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5-14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4-8·6]; rate ratio 1·37 [95% CI 1·17-1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92-1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95-1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94-1·15]; p=0·45). INTERPRETATION: Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered-eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy. FUNDING: Cancer Research UK, British Heart Foundation, UK Medical Research Council, and UK Department of Health. ispartof: LANCET ONCOLOGY vol:19 issue:1 pages:27-39 ispartof: location:England status: published

Published
2017
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19. The habitat monitoring under article 17 of the 92/43/eec Directive in Italy: the contribution of vegetation science

Author

GIGANTE, D, ANGELINI, P, ATTORRE, F, BIONDI, E, CASELLA, L, VENANZONI, R, ACOSTA, ATR, AGRILLO, E, ALEFFI, M, ALESSI, N, ALLEGREZZA, M, ANGIOLINI, C, ASSINI, S, AZZELLA, M, BAGELLA, S, BOLPAGNI, R, BONARI, G, BRACCO, F, BRULLO, S, BUFFA, G, CARLI, E, CASAVECCHIA, S, CERABOLINI, BEL, CIASCHETTI, G, CICCARELLI, D, COPIZ, R, CUTINI, M, DEL VECCHIO, S, DEL VICO, E, DI MARTINO, L, FACIONI, L, FANELLI, G, FOGGI, B, FRATTAROLI, AR, GALDENZI, D, GANGALE, C, GASPARRI, R, GIANGUZZI, Lorenzo Antonio, GIRONI, F, GIUSSO DEL GALDO, G, GUALMINI, M, GUARINO, Riccardo, LASEN, C, LASTRUCCI, L, MANELI, F, MARIOTTI, MG, PASTA, S, PAURA, B, PERRINO, EV, PETRAGLIA AR, PIRONE, G, POLDINI, L, POPONESSI, S, PRISCO, I, PUGLISI, M, RAVERA, S, SBURLINO, G, SELVAGGI, A, SPADA, F, SPAMPINATO, G, STRUMIA, S, TOMASELLI, M, TOMASELLI, V, UZUNOV,D, VICIANI, D, VILLANI, M, WAGENSOMMER, RP, ZITTI, S., GIGANTE, D, ANGELINI, P, ATTORRE, F, BIONDI, E, CASELLA, L, VENANZONI, R, ACOSTA, ATR, AGRILLO, E, ALEFFI, M, ALESSI, N, ALLEGREZZA, M, ANGIOLINI, C, ASSINI, S, AZZELLA, M, BAGELLA, S, BOLPAGNI, R, BONARI, G, BRACCO, F, BRULLO, S, BUFFA, G, CARLI, E, CASAVECCHIA, S, CERABOLINI, BEL, CIASCHETTI, G, CICCARELLI, D, COPIZ, R, CUTINI, M, DEL VECCHIO, S, DEL VICO, E, DI MARTINO, L, FACIONI, L, FANELLI, G, FOGGI, B, FRATTAROLI, AR, GALDENZI, D, GANGALE, C, GASPARRI, R, GIANGUZZI, L, GIRONI, F, GIUSSO DEL GALDO, G, GUALMINI, M, GUARINO, R, LASEN, C, LASTRUCCI, L, MANELI, F, MARIOTTI, MG, PASTA, S, PAURA, B, PERRINO, EV, PETRAGLIA AR, PIRONE, G, POLDINI, L, POPONESSI, S, PRISCO, I, PUGLISI, M, RAVERA, S, SBURLINO, G, SELVAGGI, A, SPADA, F, SPAMPINATO, G, STRUMIA, S, TOMASELLI, M, TOMASELLI, V, UZUNOV,D, VICIANI, D, VILLANI, M, WAGENSOMMER, RP, and ZITTI, S

Subjects
vegetation, BIODIVERSITY, CONSERVATION STATUS,HABITAT DIRECTIVE, VEGETATION, conservation status, Biodiversity, Habitat Directive, Habitat, monitoring, European Directive, Biodiversity, conservation status, Habitat Directive, vegetation
Abstract

The 4th National Report ex Art. 17 of the 92/43/EEC Directive in Italy (period 2013-2018) will try to fill a number of gaps still affecting the former versions of the Italian Reports, where territorial data were still missing for large parts of the country and the assessment was mostly based on the use of the expert opinion. Similar inconsistencies also emerged in other European countries (State of nature in the EU, EEA 2015). In order to reach this aim, a nationally shared protocol for monitoring the vegetation-based Annex I Habitats is currently under development. The most prominent issues addressed by the ongoing project are: i) fixing standardized, updated and scientifically grounded methodological tools, on the basis of the European guidelines (Evans & Arvela 2011, ETC-BD); ii) providing comparable data at national and European level; iii) harmonizing the territorially fragmented knowledge and iv) supporting nationally standardized measures for the conservation of terrestrial, brackish and freshwater Habitats. Promoted by the Italian Ministry for Environment (MATTM) and coordinated by the environmental agency ISPRA, the development of such a tool is being carried out by the Italian Society for Vegetation Science, with the support of a large team of experts. Open issues, such as the favourable reference values and the optimal thresholds for each considered parameter (range,area, structure and function), have to be dealt with, in a condition of large uncertainty. Due to its centrality in the assessment process, especially the concept of "typical species" should be developed with care, trying to combine the need for synthetic indicators with the great floristic diversity of the Italian Habitats. A clear definition of the parameters is crucial for a correct application of the monitoring protocol, to successfully contribute to the whole process of halting biodiversity loss in Europe.

Published
2016

20. Preliminary checklist of the Italian gypsophilous flora

Author

Musarella, CM, Spampinato, G, Mendoza Fernández, JM, Mota, JF, Alessandrini, A, Brullo, S, Caldarella, O, Ciaschetti, G, Conti, F, Di Martino L, Falci, A, GIANGUZZI, Lorenzo Antonio, Manzi, A, Minissale, P, Montanari, A, Pasta, S, Peruzzi, L, Sciandrello, S, Scuderi, L, GUARINO, Riccardo, TROIA, Angelo, Musarella, CM, Spampinato, G, Mendoza-Fernández, JM, Mota, JF, Alessandrini, A, Brullo, S, Caldarella, O, Ciaschetti, G, Conti, F, Di Martino L, Falci, A, Gianguzzi, L, Guarino, R, Manzi, A, Minissale, P, Montanari, A, Pasta, S, Peruzzi, L, Sciandrello, S, Scuderi, L, and Troìa, A

Subjects
flora, gypsophily, gypsum, soil
Abstract

The richness and uniqueness of the flora growing on gypsum substrates in Italy is known since the XIX century (Macchiati, 1888). Furthermore, the concept of plant gypsophily can be defined as the exclusiveness (or virtually exclusiveness) for living in gypsum outcropping rocks. Thus only those plant species, which show preference – or even exclusivity - for gypsum substrates, would be classified as gipsophilous (Mota et al., 2011). The main aim of this research has been the elaboration of a checklist of the Italian gypsophilous flora. The study was made possible through international collaboration between the "Mediterranea" University of Reggio Calabria (Italy) and the University of Almería (Spain). During the first step, an extensive literature review has been carried out in order to collect all available information about gypsophilous flora and to compile a preliminary list. Afterwards 18 regional botanists experts on Italian gypsum flora have been asked to rank the preference of these species for gypsum soils. Following the methodology proposed by Mota et al. (2009), the gypsophilous character of more than 100 plant species has been thus ranked on a scale ranging from 1 to 5 (with 5 representing for a total dependence on gypsum substrates). According to the obtained values, all the plant species, ranking between absolute or preferent gypsophytes, will figure in the final checklist of the gypsophytes of the whole Italian territory.

Published
2016

21. The conservation of the Italian Crop Wild Relatives in the RIBES seed-banks: first data to establish national inventories and conservation priorities

Author

Magrini, S, Atzeri, P, Bacchetta, G, Bedini, G, Carasso, V, Carta, A, Ceriani, R, Ciancaleoni, S, Di Martino,L, Di Santo, M, Fabrini, G, Forte, L, Gratani, L, Negri, V, Porceddu, M, SALMERI, Cristina Maria Bernardina, Sarigu, R, SCIALABBA, Anna, Taffetani, F, Villani, MC, Zappa, E, Mariotti, M., Magrini, S, Atzeri, P, Bacchetta, G, Bedini, G, Carasso, V, Carta, A, Ceriani, R, Ciancaleoni, S, Di Martino,L, Di Santo, M, Fabrini, G, Forte, L, Gratani, L, Negri, V, Porceddu, M, Salmeri, C, Sarigu, R, Scialabba, A, Taffetani, F, Villani, MC, Zappa, E, and Mariotti, M

Subjects
Settore BIO/01 - Botanica Generale, CWR, Crop wild relatives, Italian flora, RIBES, seed bank, crop wild relatives, conservation, Settore BIO/02 - Botanica Sistematica, Crop Wild Relatives, CWR, Seed Banks, germplasm, Seed Banks, germplasm, ex situ
Abstract

The authors present the updated results of such census in the Italian Seed Bank Network for native species conservation (RIBES) with an analysis of the contribution to the conservation of the Italian FAO priority CWR. Finally, a national priority list for conservation of CWRs was drawn up and proposed here.

Published
2016

22. The conservation of the endemic Crop Wild Relatives in the RIBES seed-banks: towards a national priority list for the Italian CWRs

Author

Magrini, S., Atzeri, P., Bacchetta, G., Bedini, G., Carasso, V., Carta, A., Ceriani, R., Ciancaleoni, S., Di Martino, L., Di Santo, M., Fabrini, G., Forte, L., Gratani, L., Negri, V., Porceddu, M., Salmeri, C., Sarigu, R., Scialabba, A., Taffetani, F., Villani, M., Zappa, E., Mariotti, M., Magrini, S, Atzeri, P, Bacchetta, G, Bedini, G, Carasso, V, Carta, A, Ceriani, R, Ciancaleoni, S, Di Martino,L, Di Santo, M, Fabrini, G, Forte, L, Gratani, L, Negri, V, Porceddu, M, Salmeri, C, Sarigu, R, Scialabba, A, Taffetani, F, Villani, MC, Zappa, E, and Mariotti, M

Subjects
Settore BIO/01 - Botanica Generale, CWR, RIBES seed-banks, Settore BIO/02 - Botanica Sistematica, Crop Wild Relatives, CWR, Seed Banks, endemic plants, conservation, conservation, crop wild relatives, Italian CWRs listed, Seed Banks, endemic plants, Crop Wild Relatives, Banche del germoplasma, Crop Wild Relatives, Endemic, Ribes
Abstract

Data of 620 crop wild relatives of species of food and fodder interest listed in the Annex I of the FAO Treaty (FAO, 2001) were collected within the census carried out by ISPRA, the Italian National Institute for Environmental Protection and Research, in 2014-2015 in order to quantify the extent of CWR representation in the Italian ex situ collections. According to such census, the RIBES network preserve 37% of the Italian CWRs listed in the FAO Treaty: in 14 out of 16 seed-banks are preserved 6,029 accessions of 229 CWR taxa, belonging to 11 families and 57 genera.

Published
2016

23. A methodological protocol for Annex i Habitats monitoring: The contribution of vegetation science

Author

Gigante, D, Attorre, F, Venanzoni, R, Acosta, Atr, Agrillo, E, Aleffi, M, Alessi, N, Allegrezza, M, Angelini, P, Angiolini, C, Assini, S, Azzella, Mm, Bagella, S, Biondi, E, Bolpagni, R, Bonari, G, Bracco, F, Brullo, Salvatore, Buffa, G, Carli, E, Caruso, G, Casavecchia, S, Casella, L, Cerabolini, Bel, Ciaschetti, G, Copiz, R, Cutini, M, Del Vecchio, S, Del Vico, E, Di Martino, L, Facioni, L, Fanelli, G, Foggi, B, Frattaroli, Ar, Galdenzi, D, Gangale, C, Gasparri, C, Genovesi, P, Gianguzzi, L, Gironi, F, GIUSSO DEL GALDO, Gianpietro, Gualmini, M, Guarino, R, Lasen, C, Lastrucci, L, Maneli, F, Pasta, S, Paura, B, Perrino, Ev, Petraglia, A, Pirone, G, Poponessi, S, Prisco, I, Puglisi, MARTA MARIA, Ravera, S, Sburlino, G, Sciandrello, Saverio, Selvaggi, A, Spada, F, Spampinato, G, Strumia, S, Tomaselli, M, Tomaselli, V, Uzunov, D, Viciani, D, Villani, M, Wagensommer, Rp, Zitti, S., Gigante, D, Attorre, F., Venanzoni, R., Acosta, ALICIA TERESA ROSARIO, Agrillo, E., Aleffi, M., Alessi, N., Allegrezza, M., Angelini, P., Angiolini, C., Assini, S., Azzella, M. M., Bagella, S., Biondi, E., Bolpagni, R., Bonari, G., Bracco, F., Brullo, S., Buffa, G., Carli, E., Caruso, G., Casavecchia, S., Casella, L., Cerabolini, B. E. L., Ciaschetti, G., Copiz, R., Cutini, Maurizio, Del Vecchio, S., Del Vico, E., Di Martino, L., Facioni, L., Fanelli, G., Foggi, B., Frattaroli, A. R., Galdenzi, D., Gangale, C., Gasparri, R., Genovesi, P., Gianguzzi, L., Gironi, F., Del Galdo, G. Giusso, Gualmini, M., Guarino, R., Lasen, C., Lastrucci, L., Maneli, F., Pasta, S., Paura, B., Perrino, E. V., Petraglia, A., Pirone, G., Poponessi, S., Prisco, Irene, Puglisi, M., Ravera, S., Sburlino, G., Sciandrello, S., Selvaggi, A., Spada, F., Spampinato, G., Strumia, S., Tomaselli, M., Tomaselli, V., Uzunov, D., Viciani, D., Villani, M., Wagensommer, R. P., Zitti, S., Acosta, A. T. R., Cutini, M., Prisco, I., and Strumia, Sandro

Subjects
92/43/EEC directive, Article 17, Biodiversity, Conservation, FCS, Italy, Natura 2000, Phytosociology, Plant community, Forestry, Ecology, Evolution, Behavior and Systematics, Ecology, Plant Science, Evolution, Ecology, Evolution,Ecology, Ecology, Evolution, Behavior and Systematic, Behavior and Systematics, Settore BIO/03 - Botanica Ambientale e Applicata
Abstract

The methodological foundations of the recently published Manual for Annex I Habitats monitoring in Italy, edited by the Italian Institute for Environmental Protection and Research (ISPRA) with the scientific support of the Italian Society for Vegetation Science (SISV), are here presented, discussed and related to the most consolidated and acknowledged scientific advances in the field of Vegetation science. The proposed methodologies aim at offering simple, yet effective, protocols and procedures towards a harmonized data collection, by way of standardized and shared technical tools, resulting in comparable evaluations of the conservation status of Annex I Habitats. The methodological framework was developed by experts including a large team of members of the SISV. Big efforts were deployed to provide indicators and parameters for biodiversity monitoring able to catch its complexity, yet simple enough to be easily measured. Diagnosis and syntaxonomical correspondences of Habitat types, sampling procedure, plot size, distribution mapping, typical species are among the principal issues here examined through a widely shared scientific discussion. The final product is a comprehensive Manual, which offers practical but scientifically sound methodological tools for an efficient and effective monitoring of Annex I Habitats. The importance of bridging across the science-policy interface is emphasized, in a general will to improve the impact of Vegetation science on conservation policy development in Europe.

Published
2016
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24. Barcoding helps threatened species: the case of Iris marsica (Iridaceae) from the protected areas of the Abruzzo (Central Italy).

Author

De Castro, O., Del Guacchio, E., Di Iorio, E., Di Maio, A., Di Martino, L., Bartolucci, F., and Conti, F.

Subjects
PROTECTED areas, IRIDACEAE, CHROMOSOME analysis, GENETIC barcoding, NATIONAL parks & reserves, RIBOSOMAL DNA
Abstract

Aiming at clarifying the discussed distribution of Iris marsica, endemic to central Italy, the authors tested the application of molecular techniques for the correct identification of this taxon, especially towards the similar, non-native I. ×germanica. In fact, it was suspected that their morphological similarity would cause misidentification in the past, causing uncertainty of distributional data and consequently a weakening of conservation measures for I. marsica. After a comparison with the topotypical population of I. marsica, the authors found that DNA barcoding based on plastid sequences and nuclear microsatellites markers represents an effective identification tool, perfectly congruent with the preliminary morphological analyses and the chromosome counts. According to the results and despite some recent indications, I. marsica actually occurs also outside the National Park of Abruzzo, Lazio and Molise (central Italy), in further protected areas. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management

Author

Grauso, F, Messalli, E. M, Salzillo, M. E, Di Martino, L, Falcone, F, Orabona, P, Caiola, A, BALBI, Giancarlo, Grauso, F, Messalli, E. M, Salzillo, M. E, Di Martino, L, Falcone, F, Orabona, P, Caiola, A, and Balbi, Giancarlo

Subjects
Ovarian Neoplasms, Fibrosarcoma, Female, Middle Aged, Human
Abstract

The authors describe a rare case of primary ovarian fibrosarcoma and the latest trends in diagnosis and therapy. The rarity of this dis-ease and the scarce number of reported cases pose serious problems in differentiating it from other fibrous forms. A 58-year-old woman presented intermittent pelvic pain and a demarcated, mobile, and solid lump in the right adnexa. Diagnostic imaging revealed a solid- cystic inhomogeneous mass occupying the right adnexa and the CA125 level was elevated. The patient underwent total hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy. Histological findings with immunomarkers led to the final diagnosis of low-grade malignant mesenchymal neoplasm derived from the ovarian stroma compatible with fibrosarcoma. Twenty-four months follow-up showed no recurrence of disease. Ovarian fibrosarcoma is very uncommon neoplasm with a poor prognosis. Despite the efforts of several authors in reporting morphological, histological, and immunohistochemical features of this neoplasm, nowadays, the diagnosis, treatment, and prognosis are unresolved issues. The present case highlights the important role of immunohistochemistry to define histological type and differential diagnosis. As demonstrated by the authors' experience, they believe that surgery is curative in the early stages with low immunohistochemical positivity for ki67 and that chemotherapy should be reserved in advanced stages with regimens in use for the treatment of sarcomas.

Published
2015

26. Seed germination and conservation of two endemic species from Central Apennines (Italy)

Author

Di Cecco, V., Di Musciano, M. ., Gratani, L., Catoni, R., Di Martino, L., and Frattaroli, Anna Rita

Subjects
restocking, germination ecology, conservation, endemic species, protected areas, conservation, endemic species, germination ecology, Mediterranean mountains, protected areas, restocking, Mediterranean mountains
Published
2017

27. Achilles tendons total rupture, open surgical treatment with PRF augmentation: clinical, morphological and functional evaluation

Author

Alviti F, Di Martino L, Villani C, Valeo M, Michele Dario Gurzì, Mangone M, Di Giorgio L, and Bernetti A

Subjects
medicine.medical_specialty, achilles tendon, STRIDE, 03 medical and health sciences, 0302 clinical medicine, gait analysis, growth factors, biologic healing enhancement, general sports trauma, imaging, diagnostic ultrasound, Medicine, Fibrous joint, 030222 orthopedics, Achilles tendon, business.industry, Ultrasound, 030229 sport sciences, General Medicine, Tendon, Surgery, Preferred walking speed, medicine.anatomical_structure, Gait analysis, Ankle, business
Abstract

Background: Changes in tendon structure after its rupture may also affect the likelihood of re-injury or strain injury to the musculotendinous complex of the plantar flexor.Purpose: The aim of our study is to investigate ankle biomechanical properties and clinical features of acute rupture of the Achilles tendon treated with open suture and PRF augmentation.Study design: Cohort study (NRS).Methods: This study has been conducted on twenty patients, divided in two groups; one group underwent conventional open repair of the Achilles tendon using the Krackow technique only, while the other group underwent surgery with Platelet-Rich-Fibrin (PRF) augmentation. We performed a clinical evaluation at 3 months, 6 months, and after 1 year. Morphological and functional tendons properties were analyzed by ultrasound and Gait Analysis.Results: The results obtained by the ultrasonographic assessment showed in the PRF group a statistically significant increasing of treated tendons the antero-posterior diameter, medio-lateral diameter. Statistically significant differences between the two groups have emerged in gait analysis performed with regard to network (Wnet). Furthermore, the network of healthy side and treated side was significantly different only in the group of patients not treated with PRF. Statistically significant values have emerged through the analysis of Pearson’s correlation between the diameter of the ultrasound treated tendon and the network, walking speed, swing speed and stride period.Conclusion: Treatment with suture and PRF shows significant morphological modifications and functional improvements compared to the results achieved with Achilles tendon suture without PRF.

Published
2017

28. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials

Author

Mcgale, P., Taylor, C., Correa, C., Cutter, D., Duane, F., Ewertz, M., Gray, R., Mannu, G., Peto, R., Whelan, T., Wang, Y., Wang, Z., Darby, S., Albain, K., Anderson, S., Arriagada, R., Barlow, W., Bergh, J., Bergsten Nordström, E., Bliss, J., Burrett, J. A., Buyse, M., Cameron, D., Carrasco, E., Clarke, M., Coleman, R., Coates, A., Collins, R., Costantino, J., Cuzick, J., Davidson, N., Davies, C., Davies, K., Delmestri, A., Di Leo, A., Dowsett, M., Elphinstone, P., Evans, V., Forbes, J., Gelber, R., Gettins, L., Geyer, C., Gianni, L., Gnant, M., Goldhirsch, A., Godwin, J., Gregory, C., Hayes, D., Hill, C., Ingle, J., Jakesz, R., James, S., Janni, W., Kaufmann, M., Kerr, A., Liu, H., Mackinnon, E., Martín, M., Mchugh, T., Morris, P., Norton, L., Ohashi, Y., Paik, S., Pan, H. C., Perez, E., Piccart, M., Pierce, L., Pritchard, K., Pruneri, G., Raina, V., Ravdin, P., Robertson, J., Rutgers, E., Shao, Y. F., Sparano, J., Swain, S., Valagussa, P., Viale, G., Von Minckwitz, G., Winer, E., Wiang, X., Wood, Abe O, W., Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Ohashi, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Haybittle, Jl, Leonard, Cf, Calais, G, Geraud, P, Collett, V, Davies, C, Delmestri, A, Sayer, J, Harvey, Vj, Holdaway, Im, Kay, Rg, Mason, Bh, Forbes, Jf, Wilcken, N, Bartsch, R, Dubsky, P, Fesl, C, Fohler, H, Gnant, M, Greil, R, Jakesz, R, Lang, A, Luschin-Ebengreuth, G, Marth, C, Mlineritsch, B, Samonigg, H, Singer, Cf, Steger, Gg, Stöger, H, Canney, P, Yosef, Hm, Focan, C, Peek, U, Oates, Gd, Powell, J, Durand, M, Mauriac, L, Di Leo, A, Dolci, S, Larsimont, D, Nogaret, Jm, Philippson, C, Piccart, Mj, Masood, Mb, Parker, D, Price, Jj, Lindsay, Ma, Mackey, J, Martin, M, Hupperets, Ps, Bates, T, Blamey, Rw, Chetty, U, Ellis, Io, Mallon, E, Morgan, Da, Patnick, J, Pinder, S, Olivotto, I, Ragaz, J, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Norton, L, Weiss, Rb, Abu-Zahra, Ht, Portnoj, Sm, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett-Lee, Pj, Mansel, Re, Monypenny, Ij, Gordon, Nh, Davis, Hl, Cuzick, J, Lehingue, Y, Romestaing, P, Dubois, Jb, Delozier, T, Griffon, B, Mace Lesech, J, Brain, E, de La Lande, B, Mouret-Fourme, E, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, Jr, Harbeck, N, Jänicke, F, Meisner, C, Schmitt, M, Thomssen, C, Meier, P, Shan, Y, Shao, Yf, Wang, X, Zhao, Db, Chen, Zm, Pan, Hc, Howell, A, Swindell, R, Burrett, Ja, Clarke, M, Collins, R, Correa, C, Cutter, D, Darby, S, Davies, K, Elphinstone, P, Evans, V, Gettins, L, Godwin, J, Gray, R, Gregory, C, Hermans, D, Hicks, C, James, S, Kerr, A, Liu, H, Mackinnon, E, Lay, M, Mcgale, P, Mchugh, T, Morris, P, Peto, R, Taylor, C, Wang, Y, Albano, J, de Oliveira CF, Gervásio, H, Gordilho, J, Ejlertsen, B, Jensen, Mb, Johansen, H, Mouridsen, H, Palshof, T, Gelman, Rs, Harris, Jr, Hayes, D, Henderson, C, Shapiro, Cl, Winer, E, Christiansen, P, Ewertz, M, Møller, S, Mouridsen, Ht, Trampisch, Hj, Dalesio, O, de Vries EG, Rodenhuis, S, van Tinteren, H, Comis, Rl, Davidson, Ne, Robert, N, Sledge, G, Solin, Lj, Sparano, Ja, Tormey, Dc, Wood, W, Cameron, D, Dixon, Jm, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, Jg, Treurniet-Donker, Ad, van Putten WL, Rotmensz, N, Veronesi, U, Viale, G, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, Jp, Rutgers, E, van de Velde CJ, Cunningham, Mp, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, Lj, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Luporsi, E, Namer, M, Eiermann, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, Ju, Costa, Sd, Eidtmann, H, Gerber, B, Jackisch, C, Loibl, S, von Minckwitz, G, de Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, Mc, Sacco, M, Valentini, M, Mcardle, Cs, Smith, Dc, Stallard, S, Dent, Dm, Gudgeon, Ca, Hacking, A, Murray, E, Panieri, E, Werner, Id, Carrasco, E, Segui, Ma, Galligioni, E, Lopez, M, Erazo, A, Medina, Jy, Horiguchi, J, Takei, H, Fentiman, Is, Hayward, Jl, Rubens, Rd, Skilton, D, Scheurlen, H, Sohn, Hc, Untch, M, Dafni, U, Markopoulos, C, Fountzilas, G, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Tinterri, C, Margreiter, R, de Lafontan, B, Mihura, J, Roché, H, Asselain, B, Salmon, Rj, Vilcoq, Jr, André, F, Arriagada, R, Delaloge, S, Hill, C, Koscielny, S, Michiels, S, Rubino, C, A'Hern, R, Bliss, J, Ellis, P, Kilburn, L, Yarnold, Jr, Benraadt, J, Kooi, M, van de Velde AO, van Dongen JA, Vermorken, Jb, Castiglione, M, Coates, A, Colleoni, M, Collins, J, Forbes, J, Gelber, Rd, Goldhirsch, A, Lindtner, J, Price, Kn, Regan, Mm, Rudenstam, Cm, Senn, Hj, Thuerlimann, B, Bliss, Jm, Chilvers, Ce, Coombes, Rc, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Foster, L, George, Wd, Stewart, Hj, Stroner, P, Borovik, R, Hayat, H, Inbar, Mj, Peretz, T, Robinson, E, Bruzzi, P, Del Mastro, L, Pronzato, P, Sertoli, Mr, Venturini, M, Camerini, T, De Palo, G, Di Mauro MG, Formelli, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Cocconi, G, Colozza, A, Passalacqua, R, Aogi, K, Takashima, S, Abe, O, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, van de Water, W, van Nes JG, Christiaens, R, Neven, P, Paridaens, R, Van den Bogaert, W, Braun, S, Martin, P, Romain, S, Janauer, M, Seifert, M, Sevelda, P, Zielinski, Cc, Hakes, T, Hudis, Ca, Wittes, R, Giokas, G, Kondylis, D, Lissaios, B, de la Huerta, R, Sainz, Mg, Altemus, R, Camphausen, K, Cowan, K, Danforth, D, Lichter, A, Lippman, M, O'Shaughnessy, J, Pierce, Lj, Steinberg, S, Venzon, D, Zujewski, Ja, D'Amico, C, Lioce, M, Paradiso, A, Chapman, Ja, Gelmon, K, Goss, Pe, Levine, Mn, Meyer, R, Parulekar, W, Pater, Jl, Pritchard, Ki, Shepherd, Le, Tu, D, Whelan, T, Ohno, S, Anderson, S, Bass, G, Brown, A, Bryant, J, Costantino, J, Dignam, J, Fisher, B, Geyer, C, Mamounas, Ep, Paik, S, Redmond, C, Swain, S, Wickerham, L, Wolmark, N, Baum, M, Jackson, Im, Palmer, Mk, Perez, E, Ingle, Jn, Suman, Vj, Bengtsson, No, Emdin, S, Jonsson, H, Lythgoe, Jp, Kissin, M, Erikstein, B, Hannisdal, E, Jacobsen, Ab, Varhaug, Je, Gundersen, S, Hauer-Jensen, M, Høst, H, Nissen-Meyer, R, Reinertsen, K, Mitchell, Ak, Robertson, Jf, Ueo, H, Di Palma, M, Mathé, G, Misset, Jl, Levine, M, Morimoto, K, Takatsuka, Y, Crossley, E, Harris, A, Talbot, D, Taylor, M, di Blasio, B, Ivanov, V, Paltuev, R, Semiglazov, V, Brockschmidt, J, Cooper, Mr, Falkson, Ci, Dowsett, M, Makris, A, Parton, M, Pennert, K, Powles, Tj, Smith, Ie, Gazet, Jc, Browne, L, Graham, P, Corcoran, N, Businico, A, Deshpande, N, di Martino, L, Douglas, P, Lindtner, A, Notter, G, Bryant, Aj, Ewing, Gh, Firth, La, Krushen-Kosloski, Jl, Anderson, H, Killander, F, Malmström, P, Rydén, L, Arnesson, Lg, Carstensen, J, Dufmats, M, Fohlin, H, Nordenskjöld, B, Söderberg, M, Carpenter, Jt, Murray, N, Royle, Gt, Simmonds, Pd, Albain, K, Barlow, W, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, Ck, Ravdin, Pm, Adolfsson, J, Bergh, J, Bondesson, T, Celebioglu, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Göransson, E, Iiristo, M, Johansson, U, Lenner, E, Löfgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, af Trampe, E, Wadström, C, Janni, W, Maibach, R, Thürlimann, B, Hakama, M, Holli, K, Isola, J, Rouhento, K, Saaristo, R, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, Ah, Fyles, A, Meakin, Jw, Panzarella, T, Bahi, J, Reid, M, Spittle, M, Bishop, H, Bundred, Nj, Forsyth, S, Pinder, Se, Sestak, I, Deutsch, Gp, Kwong, Dl, Pai, Vr, Senanayake, F, Martin, Al, Boccardo, F, Rubagotti, A, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, Js, Carlomagno, C, De Laurentiis, M, De Placido, S, Williams, L, Broglio, K, Buzdar, Au, Hsu, L, Love, Rr, Ahlgren, J, Garmo, H, Holmberg, L, Liljegren, G, Lindman, H, Wärnberg, F, Asmar, L, Jones, Se, Gluz, O, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, Bk, Chlebowski, Rt, Caffier, H., McGale, P, Taylor, C, Correa, C, Cutter, D, Duane, F, Ewertz, M, Gray, R, Mannu, G, Peto, R, Whelan, T, Wang, Y, Wang, Z, Darby, S, Biomedische Technologie, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Mcgale, P, DE LAURENTIIS, Michelino, Other departments, CCA -Cancer Center Amsterdam, and Radiotherapy

Subjects
medicine.medical_specialty, medicine.medical_treatment, Breast Neoplasms, Rate ratio, Lower risk, Systemic therapy, Statistical significance, Medicine, Humans, Mastectomy, Randomized Controlled Trials as Topic, business.industry, Articles, General Medicine, Surgery, Radiation therapy, Axilla, Neoplasm Recurrence, medicine.anatomical_structure, Local, Meta-analysis, Lymphatic Metastasis, Lymph Node Excision, Female, Neoplasm Recurrence, Local, business, Breast Neoplasm, Human
Abstract

BACKGROUND: Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.METHODS: We did a meta-analysis of individual data for 8135 women randomly assigned to treatment groups during 1964-86 in 22 trials of radiotherapy to the chest wall and regional lymph nodes after mastectomy and axillary surgery versus the same surgery but no radiotherapy. Follow-up lasted 10 years for recurrence and to Jan 1, 2009, for mortality. Analyses were stratified by trial, individual follow-up year, age at entry, and pathological nodal status.FINDINGS: 3786 women had axillary dissection to at least level II and had zero, one to three, or four or more positive nodes. All were in trials in which radiotherapy included the chest wall, supraclavicular or axillary fossa (or both), and internal mammary chain. For 700 women with axillary dissection and no positive nodes, radiotherapy had no significant effect on locoregional recurrence (two-sided significance level [2p]>0·1), overall recurrence (rate ratio [RR], irradiated vs not, 1·06, 95% CI 0·76-1·48, 2p>0·1), or breast cancer mortality (RR 1·18, 95% CI 0·89-1·55, 2p>0·1). For 1314 women with axillary dissection and one to three positive nodes, radiotherapy reduced locoregional recurrence (2pINTERPRETATION: After mastectomy and axillary dissection, radiotherapy reduced both recurrence and breast cancer mortality in the women with one to three positive lymph nodes in these trials even when systemic therapy was given. For today's women, who in many countries are at lower risk of recurrence, absolute gains might be smaller but proportional gains might be larger because of more effective radiotherapy.FUNDING: Cancer Research UK, British Heart Foundation, UK Medical Research Council.

Published
2016
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30. EU habitats monitoring along the coastal dunes of the LTER sites of Abruzzo and Molise (Italy)

Author

Stanisci, A, Acosta, A. T. R., Carranza, M. L., DE CHIRO, M, DEL VECCHIO, S, DI MARTINO, L, Frattaroli, Anna Rita, Fusco, S, Izzi, C. F., Pirone, G, Prisco, I., Stanisci, A., Acosta, ALICIA TERESA ROSARIO, Carranza, M. L., De Chiro, M., Del Vecchio, S., Di Martino, L., Frattaroli, A. R., Fusco, S., Izzi, C. F., Pirone, G., and Prisco, I.

Subjects
coastal dune, spatial distribution, species composition, coastal dune, EU habitats, species composition, alien species, spatial distribution, EU habitats, alien species, coastal dunes
Published
2014

31. The habitat monitoring under article 17 of the 92/43/EEC Directive in Italy: the contribution of vegetation science

Author

Gigante, D., Angelini, P., Attorre, F., Biondi, E., Casella, L., Venanzoni, R., Team (Acosta ATR, SISV Team (Acosta A. T. R., Agrillo, E., Aleffi, M., Alessi, N., Allegrezza, M., Angiolini, C., Assini, S., Azzella, M., Bagella, S., Bolpagni, R., Bonari, G., Bracco, F., Brullo, S., Buffa, G., Carli, E., Casavecchia, S., Cerabolini, BRUNO ENRICO LEONE, Ciaschetti, G., Ciccarelli, D., Copiz, R., Cutini, M., Del Vecchio, S., Del Vico, E., Di Martino, L., Facioni, L., Fanelli, G., Foggi, B., Frattaroli, A. R., Galdenzi, D., Gangale, C, Gasparri, R., Gianguzzi, L., Gironi, F., Giusso del Galdo, G., Gualmini, M., Guarino, R., Lasen, C., Lastrucci, L., Maneli, F., Mariotti, M. G., Pasta, S., Perrino, E. V., Petraglia, A., Pirone, G., Poldini, L., Poponessi, S., Prisco, I., Puglisi, M., Ravera, S., Sburlino, G., Selvaggi, A, Spada, F., Spampinato, G., Strumia, S., Tomaselli, M., Tomaselli, V., Uzunov, D., Viciani, D., Villani, M., Wagensommer, R. P., and Zitti, S.

Published
2016

32. The SISV support to the implementation of a national manual for monitoring the Habitats of the 92/43/EEC Directive in Italy

Author

Gigante, D., Angelini, P., Attorre, F., Biondi, E., Casella, L., Venanzoni, R., Acosta, A.T.R., Agrillo, E., Aleffi, M., Alessi, N., Allegrezza, M., Angiolini, C., Assini, S., Azzella, M., Bagella, S., Bolpagni, R., Bonari, G., Bracco, F., Brullo, S., Buffa, G., Carli, E., Casavecchia, S., Cerabolini, B.E.L., Ciaschetti, G., Ciccarelli, D., Copiz, R., Cutini, M., Del Vecchio, S., Del Vico, E., Di Martino, L., Facioni, L., Fanelli, G., Foggi, B., Frattaroli, A.R., Galdenzi, D., Gangale, C., Gasparri, R., Gianguzzi, L., Gironi, F., Giusso Del Galdo, G., Gualmini, M., Guarino, R., Lasen, C., Lastrucci, L., Maneli, F., Mariotti, M.G., Pasta, S., Paura, B., Perrino, E.V., Petraglia, A., Pirone, G., Poldini, L., Poponessi, S. ., Prisco, I ., Puglisi, M., Ravera, S., Sburlino, G., Selvaggi, A., Spada, F., Spampinato, G., Strumia, S., Tomaselli, M., Tomaselli, V., Uzunov, D., Viciani, D., Villani, M., Wagensommer, R.P., Zitti, S., Gigante, D., Angelini, P., Attorre, F., Biondi, E., Casella, L., Venanzoni, R., Acosta, A., Agrillo, E., Aleffi, M., Alessi, N., Allegrezza, M., Angiolini, C., Assini, S., Azzella, M., Bagella, S., Bolpagni, R., Bonari, G., Bracco, F., Brullo, S., Buffa, G., Carli, E., Casavecchia, S., Cerbolini, B., Ciaschetti, G., Ciccarelli, D., Copiz, R., Cutini, M., VECCHIO S, D., Del, V., MARTINO L, D., Facioni, L., Fanelli, G., Foggi, B., Frattaroli, A., Galdenzi, D., Gangale, C., Gasparri, R., Gianguzzi, L., Gironi, F., Giusso, G., Gualmini, M., Guarino, R., Lasen, C., Lastrucci, L., Maneli, F., Mariotti, M., Pasta, S., Paura, B., Perrino, E., Petraglia, A., Pirone, G., Poldini, L., Poponessi, S., Prisco, I., Puglisi, M., Ravera, S., Sburlino, G., Selvaggi, A., Spada, F., Spampinato, G., Strumia, S., Tomaselli, M., Tomaselli, V., Uzunov, D., Viciani, D., Villani, M., Wagensommer, R., and Zitti, S.

Subjects
Habitat, Natura 2000, monitoring, Italy, BIODIVERSITY, CONSERVATION STATUS, HABITAT DIRECTIVE, VEGETATION, Settore BIO/03 - Botanica Ambientale E Applicata
Abstract

The 4th National Report ex Art. 17 of the 92/43/EEC Directive in Italy (period 2013-2018) will try to fill a number of gaps still affecting the former versions of the Italian Reports, where territorial data were still missing for large parts of the country and the assessment was mostly based on the use of the expert opinion. Similar inconsistencies also emerged in other European countries (State of nature in the EU, EEA 2015). In order to reach this aim, a nationally shared protocol for monitoring the vegetation-based Annex I Habitats is currently under development. The most prominent issues addressed by the ongoing project are: i) fixing standardized, updated and scientifically grounded methodological tools, on the basis of the European guidelines (Evans & Arvela 2011, ETC-BD); ii) providing comparable data at national and European level; iii) harmonizing the territorially fragmented knowledge and iv) supporting nationally standardized measures for the conservation of terrestrial, brackish and freshwater Habitats. Promoted by the Italian Ministry for Environment (MATTM) and coordinated by the environmental agency ISPRA, the development of such a tool is being carried out by the Italian Society for Vegetation Science, with the support of a large team of experts. Open issues, such as the favourable reference values and the optimal thresholds for each considered parameter (range, area, structure and function), have to be dealt with, in a condition of large uncertainty. Due to its centrality in the assessment process, especially the concept of "typical species" should be developed with care, trying to combine the need for synthetic indicators with the great floristic diversity of the Italian Habitats. A clear definition of the parameters is crucial for a correct application of the monitoring protocol, to successfully contribute to the whole process of halting biodiversity loss in Europe.

Published
2016

33. A methodological protocol for Annex I Habitats monitoring: the contribution of Vegetation science

Author

Gigante, D., Attorre, F., Venanzoni, R., Acosta, A. T. R., Agrillo, E., Allegrezza, ALESSI N., Angelini, P., Angiolini, C., Assini, S., Azzella, M. M., Bagella, S., Biondi, E., Bolpagni, R., Bonari, G., Bracco, F., Brullo, S., Buffa, G., Carli, E., Caruso, G., Casavecchia, S., Casella, L., Cerabolini, B., Ciaschetti, G., Copiz, R., Cutini, M., DEL VECCHIO, S., DEL VICO, E., DI MARTINO, L., Facioni, L., Fanelli, G., Foggi, B., Frattaroli, Anna Rita, Galdenzi, D., Gangale, C., Gasparri, R., Genovesi, P., Gianguzzi, L., Gironi, F., GIUSSO DEL GALDO, G., Gualmini, M., Guarino, R., Lasen, C., Lastrucci, L., Maneli, F., Pasta, S., Paura, B., Perrino, E. V., Petraglia, A., Pirone, Gianfranco, Poponessi, S., Prisco, I., Puglisi, M., Ravera, S., Sburlino, G., Sciandrello, S., Selvaggi, A., Spada, F., Spampinato, G., Strumia, S., Tomaselli, M., Tomaselli, V., Uzunov, D., Viciani, D., Villani, M., Wagensommer, R. P., and Zitti, S.

Subjects
Article 17, Biodiversity, Conservation, FCS, Italy, Natura 2000, Phytosociology, Plant community, 92/43/EEC Directive, Italy, 92/43/EEC Directive, Article 17, FCS, Natura 2000, Biodiversity, Conservation, Plant community, Phytosociology
Published
2016

34. The Habitat monitoring under article 17 of the 92/43/EEC Directive in Italy: the contribution of the vegetation science

Author

Gigante, D, Angelini, P, Attorre, F, Biondi, E, Casella, L, Venanzoni, R, Acosta, Atr, Agrillo, E, Aleffi, M, Alessi, N, Allegrezza, M, Angiolini, C, Assini, S, Azzella, M, Bagella, S, Bolpagni, R, Bonari, G, Bracco, F, Brullo, S, Buffa, G, Carli, E, Casavecchia, S, Cerabolini, Bel, Ciaschetti, G, Ciccarelli, D, Copiz, R, Cutini, M, Del Vecchio, S, Del Vico, E., Di Martino, L, Facioni, L, Fanelli, G, Foggi, B, Frattaroli, Ar, Galdenzi, D, Gangale, C, Gasparri, R, Gianguzzi, L, Gironi, F, Giusso Del Galdo, G, Gualmini, M, Guarino, R, Lasen, C, Lastrucci, L, Maneli, F, Mariotti, Mauro, Pasta, S, Paura, B, Perrino, Ev, Petraglia, A, Pirone, G, Poldini, L, Poponessi, S, Prisco, I, Puglisi, M, Ravera, S, Sburlino, G, Selvaggi, A, Spada, F, Spampinato, G, Strumia, S, Tomaselli, M, Tomaselli, V, Uzunov, D, Viciani, D, Villani, M, Wagensommer, Rp, and Zitti, S.

Subjects
Vegetation, Biodiversity, conservation status, Habitat Directive, Vegetation, conservation status, Biodiversity, Habitat Directive
Published
2016

35. KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation

Author

Goodman, W.A. Omenetti, S. Date, D. Di Martino, L. De Salvo, C. Kim, G.-D. Chowdhry, S. Bamias, G. Cominelli, F. Pizarro, T.T. Mahabeleshwar, G.H.

Abstract

Inflammatory bowel disease (IBD) is associated with dysregulated macrophage responses, such that quiescent macrophages acquire a pro-inflammatory activation state and contribute to chronic intestinal inflammation. The transcriptional events governing macrophage activation and gene expression in the context of chronic inflammation such as IBD remain incompletely understood. Here, we identify Kruppel-like transcription factor-6 (KLF6) as a critical regulator of pathogenic myeloid cell activation in human and experimental IBD. We found that KLF6 was significantly upregulated in myeloid cells and intestinal tissue from IBD patients and experimental models of IBD, particularly in actively inflamed regions of the colon. Using complementary gain- and loss-of-function studies, we observed that KLF6 promotes pro-inflammatory gene expression through enhancement of nuclear factor κB (NFκB) signaling, while simultaneously suppressing anti-inflammatory gene expression through repression of signal transducer and activator of transcription 3 (STAT3) signaling. To study the in vivo role of myeloid KLF6, we treated myeloid-specific KLF6-knockout mice (Mac-KLF6-KO) with dextran sulfate sodium (DSS) and found that Mac-KLF6-KO mice were protected against chemically-induced colitis; this highlights the central role of myeloid KLF6 in promoting intestinal inflammation. Collectively, our results point to a novel gene regulatory program underlying pathogenic, pro-inflammatory macrophage activation in the setting of chronic intestinal inflammation.

Published
2016

36. Analysis of intraspecific seed diversity in Astragalus aquilanus (Fabaceae), an endemic species of Central Apennine.

Author

Di Cecco, V., Di Musciano, M., D'Archivio, A. A., Frattaroli, A.R., Di Martino, L., and Pritchard, H.

Subjects
FISHER discriminant analysis, LEGUMES, SEEDS, INFRARED spectroscopy, IMAGE analysis
Abstract

This work aims to study seeds of the endemic species Astragalus aquilanus from four different populations of central Italy. We investigated seed morpho‐colorimetric features (shape and size) and chemical differences (through infrared spectroscopy) among populations and between dark and light seeds.Seed morpho‐colorimetric quantitative variables, describing shape, size and colour traits, were measured using image analysis techniques. Fourier transform infrared (FT‐IR) spectroscopy was used to attempt seed chemical characterisation. The measured data were analysed by step‐wise linear discriminant analysis (LDA). Moreover, we analysed the correlation between the four most important traits and six climatic variables extracted from WorldClim 2.0.The LDA on seeds traits shows clear differentiation of the four populations, which can be attributed to different chemical composition, as confirmed by Wilk's lambda test (P < 0.001). A strong correlation between morphometric traits and temperature (annual mean temperature, mean temperature of the warmest and coolest quarter), colorimetric traits and precipitation (annual precipitation, precipitation of wettest and driest quarter) was observed.The characterisation of A. aquilanus seeds shows large intraspecific plasticity both in morpho‐colorimetric and chemical composition. These results confirm the strong relationship between the type of seed produced and the climatic variables. [ABSTRACT FROM AUTHOR]

Published
2019
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40. Post-infectious functional gastrointestinal disorders in children

Author

Saps M, Pensabene L, Di Martino L, Wechsler J, Zheng X, Di Lorenzo C., STAIANO, ANNAMARIA, Saps, M, Pensabene, L, Di Martino, L, Staiano, Annamaria, Wechsler, J, Zheng, X, and Di Lorenzo, C.

Abstract

OBJECTIVE: To investigate the development of functional gastrointestinal disorders (FGIDs) after an episode of acute bacterial gastroenteritis (AGE) in children. STUDY DESIGN: A cohort study of children 3 to 19 years old with a positive result on a bacterial stool culture. 44 patients in each arm (unidirectional alpha of 0.05, power of 0.80). Children presenting at two pediatric hospitals (United States and Italy) for AGE who tested positive for bacteria on stool culture (2001-2005) were contacted at least 6 months after the episode. Exposed children were matched with control subjects of similar age and sex consulting to the same hospitals for trauma or well-child visit within 4 weeks of the index case. Symptoms were evaluated with a validated questionnaire for FGIDs assessing pain, diarrhea, and disability. RESULTS: 88 patients (46 boys; mean age, 8.1 years; age range, 3-19 years) were recruited. Bacteria included Salmonella (54%), Campylobacter (32%), and Shigella (14%). 36% of exposed patients and 11% of control subjects complained of abdominal pain (P < .01). 87% had irritable bowel syndrome and 24% had dyspepsia. 56% reported onset of pain following the AGE. CONCLUSION: There is a significant increase in cases of FGIDs after bacterial infections in children.

Published
2008

46. On minimally irreducible groups of degree the product of two primes

Author

DALLA VOLTA, F., DI MARTINO, L., Previtali, Andrea, DALLA VOLTA, F, DI MARTINO, L, and Previtali, A

Subjects
representation, group, MAT/02 - ALGEBRA, irreducible
Abstract

We determine the minimally irreducible groups with proper non-soluble socle, whose degree is the product of two primes.

Published
2003

48. Analysis of diaspore morphology and seed germination in Bubon macedonicum L., a rare species in Italy.

Author

Di Cecco, V., Paura, B., Bufano, A., Di Santo, P., Di Martino, L., and Frattaroli, A. R.

Subjects
PLANT species, DIASPORE, PLANT morphology, GERMINATION, ENDANGERED species
Abstract

Bubon macedonicum L. is a chasmophytic species of south-eastern Europe. In Italy, it has been detected only in Rocca Monforte (Campobasso, central Italy). This rare species is included in the IUCN Red Lists of Critically Endangered Italian Flora, and there are no studies relating to B. macedonicum biology. The seed germination dynamics of this species was studied with the aim of building up an appropriate germination protocol to be used in ex situ conservation. On the basis of an ISTA protocol, about 3,000 seeds were collected from Rocca Monforte in August 2013. Fifty seeds were measured. The considered parameters were seed length, width, thickness, seed surface, volume, density, surface/mass ratio and eccentricity index. The morphometric parameters examined showed morphological dormancy, where a short warm period is necessary for embryo growth and seed germination. The results showed high germination percentages under the different conditions of temperature, pH, GA3 and photoperiod. Only at 5 °C was there no germination. Finally, the seeds maintain high germination percentages from the seed storage process after 130 and 390 days. This factor can be considered of great importance for the conservation of B. macedonicum over the medium and long term. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Role of the association of high-risk HPV identified by real-time PCR in cervical preneoplastic lesions

Author

Balbi, G., Napolitano, A., Giordano, F., Capuano, S., Manganaro, M. A., Di Martino, L., Fusco, D., Flavio Grauso, Seguino, E., Balbi, Giancarlo, A., Napolitano, F., Giordano, S., Capuano, M. A., Manganaro, L., Di Martino, D., Fusco, F., Grauso, and E., Seguino

Subjects
virus diseases, Squamous cell carcinoma, Endometrial carcinoma, Ichthyosis uteri, female genital diseases and pregnancy complications
Abstract

Summary Objective: To evaluate the effects of infection in multiple types of high-risk human papillomavirus (HPV) in cervical preneoplastic lesions in patients undergoing colposcopy following a diagnosis of atypical squamous cells of unknown significance (ASCUS) and low-grade squamous intraepithelial (LSIL) cytology. Materials and Methods: Between 2009 and 2010, 2,500 patients were recruited with a mean age of 35 ± 5 years. Screening for cervical cancer was performed and in case of ASCUS and LSIL the patients underwent col¬poscopy. The tests for thè detection and typing of virai DNA (HPV - DNA test) were performed on cervical swab with real-time PCR amplification. Result : The prevalence of infection was 70% (1579/2256) in the patients recruited. In relation to the degree of preneo¬plastic lesions some high-risk HPV virus genotypes were identified: HPV 16 (319/1466), HPV 18 (164/1466), HPV 45 (76/1466), HPV 31 (215/1466), HPV 52 (145/1466), HPV 58 (55/1466) HPV 56 (79/1466), HPV 51 (110/1466), HPV 6(138/1466), HPV 11 (88/1466), HPV 42 (34/1466), HPV 53 (43/1466). In case of high-grade lesions of CIN (CIN2 and CIN3) a greater HPV co-infection was detected and in particular thè association from 16 to 18 (70%), 16-33 (18%) and 16 to 52 (12%). Conclusions: Infection caused by the simultaneous presence of multiple HPV genotypes appears to be associated with a significantly increased risk of high-grade lesions of CIN or invasive cancer than the presence of single virus infections. The infection with multiple HPV types is a significant risk factor for high-grade lesions of CIN in women undergoing colposcopy for ASCUS cytology / LSIL. The use of real-time PCR has shown the ability not only to identify the different types of HPV, but also to monitor quantitatively thè same over lime, and during the study phase, to eval¬uate the sensitivity and specificity of the method in comparison with other techniques. Key words: Squamous cell carcinoma; Endometrial carcinoma; Ichthyosis uteri.

Published
2012

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