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2. Fluorescence in situ hybridization analysis of minimal residual disease and the relevance of the der(9) deletion in imatinib-treated patients with chronic myeloid leukemia.

Author

Calabrese G, Fantasia D, Di Gianfilippo R, Stuppia L, Di Lorenzo R, and Palka G

Subjects
Benzamides, Chromosomes, Human, Pair 9, Follow-Up Studies, Humans, Imatinib Mesylate, In Situ Hybridization, Fluorescence, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics, Neoplasm, Residual diagnosis, Neoplasm, Residual genetics, Chromosome Deletion, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Piperazines therapeutic use, Pyrimidines therapeutic use
Abstract

Forty-six patients with chronic myeloid leukemia receiving imatinib mesylate (39 in chronic phase, one in accelerated phase, and six in blastic crisis), were studied for a 20-62 month follow-up period by cytogenetics and fluorescence in situ hybridization using dual-color, dual-fusion BCR and ABL probes. This approach provided valuable results for disease management of analysis.

Published
2006

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