4,383 results on '"Di Cesare, A"'
Search Results
2. Effective treatment of sarcoptic mange in an alpaca (Vicugna pacos) using fluralaner: a case report
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Sala, Giulia, Gazzonis, Alessia Libera, Pravettoni, Davide, Cafiso, Alessandra, Grilli, Guido, Ferrulli, Vincenzo, Boccardo, Antonio, Di Cesare, Federica, Pavesi, Laura Filippone, and Zanzani, Sergio
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- 2024
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3. Long-term drug survival of risankizumab in psoriasis: insights from a real-life multicenter study on hard-to-treat areas
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Michelucci, A., Margiotta, F. Manzo, Cartocci, A., Panduri, S., Trovato, E., Calpalbo, E., Dragotto, M., Di Cesare, A., Rosi, E., Rossari, S., Magnano, M., Pescitelli, L., Buggiani, G., Simoni, B., Lorenzoni, E., Ricceri, F., Savarese, I., Milanesi, N., Rubegni, P., Prignano, F., and Romanelli, M.
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- 2024
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4. Genome-centric metagenomes unveiling the hidden resistome in an anchialine cave
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Tanja Vojvoda Zeljko, Katarina Kajan, Branko Jalžić, Anyi Hu, Neven Cukrov, Marija Marguš, Nuša Cukrov, Tamara Marković, Raffaella Sabatino, Andrea Di Cesare, and Sandi Orlić
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Antibiotic resistance gene ,Resistome ,Mobile genetic element ,Anchialine cave ,Subterranean estuary ,Metagenomics ,Environmental sciences ,GE1-350 ,Microbiology ,QR1-502 - Abstract
Abstract Background Antibiotic resistance is a critical global concern, posing significant challenges to human health and medical treatments. Studying antibiotic resistance genes (ARGs) is essential not only in clinical settings but also in diverse environmental contexts. However, ARGs in unique environments such as anchialine caves, which connect both fresh and marine water, remain largely unexplored despite their intriguing ecological characteristics. Results We present the first study that comprehensively explores the occurrence and distribution of ARGs and mobile genetic elements (MGEs) within an anchialine cave. Utilizing metagenomic sequencing we uncovered a wide array of ARGs with the bacitracin resistance gene, bacA and multidrug resistance genes, being the most dominant. The cave’s microbial community and associated resistome were significantly influenced by the salinity gradient. The discovery of novel β-lactamase variants revealed the cave’s potential as a reservoir for previously undetected resistance genes. ARGs in the cave demonstrated horizontal transfer potential via plasmids, unveiling ecological implications. Conclusions These findings highlight the need for further exploration of the resistome in unique environments like anchialine caves. The interconnected dynamics of ARGs and MGEs within anchialine caves offer valuable insights into potential reservoirs and mechanisms of antibiotic resistance in natural ecosystems. This study not only advances our fundamental understanding but also highlights the need for a comprehensive approach to address antibiotic resistance in diverse ecological settings.
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- 2024
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5. Genome-centric metagenomes unveiling the hidden resistome in an anchialine cave
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Vojvoda Zeljko, Tanja, Kajan, Katarina, Jalžić, Branko, Hu, Anyi, Cukrov, Neven, Marguš, Marija, Cukrov, Nuša, Marković, Tamara, Sabatino, Raffaella, Di Cesare, Andrea, and Orlić, Sandi
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- 2024
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6. Author Correction: Humanoid facial expressions as a tool to study human behaviour
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Lombardi, G., Sciutti, A., Rea, F., Vannucci, F., and Di Cesare, G.
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- 2024
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7. Cerebral perfusion software: comparative evaluation
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Fagotti, Cristina, Colarieti, Filippo, Cella, Marco, Catalucci, Alessia, Anselmi, Monica, Arrigoni, Francesco, Palumbo, Pierpaolo, Bruno, Federico, Barile, Antonio, Di Cesare, Ernesto, and Splendiani, Alessandra
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- 2024
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8. Prognostic validity of coronary flow reserve (CFR)-derived mapping-stress MRI in the risk stratification of suspected or known CAD patients
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Lamja, Stefania, Boccetti, Danilo, Palumbo, Pierpaolo, Barile, Antonio, and Di Cesare, Ernesto
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- 2024
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9. Reliability of Machine Learning in functional assessment in cardiac magnetic resonance imaging
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Boccetti, Danilo, Lamja, Stefania, Palumbo, Pierpaolo, Barile, Antonio, and Di Cesare, Ernesto
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- 2024
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10. Prolonged pre-firing pancreatic compression with linear staplers in distal pancreatectomy: a valuable technique for post-operative pancreatic fistula prevention
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Quero, Giuseppe, Laterza, Vito, Schena, Carlo Alberto, Massimiani, Giuseppe, Lucinato, Chiara, Fiorillo, Claudio, Mezza, Teresa, Taglioni, Flavia, Menghi, Roberta, Di Cesare, Ludovica, Biffoni, Beatrice, De Sio, Davide, Rosa, Fausto, Tondolo, Vincenzo, and Alfieri, Sergio
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- 2024
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11. Selection criteria for osteoid osteomas/osteoblastoma’s treatment by ablation with radiofrequency needles or high intensity focused ultrasound: our experience
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Spano, Giulia, Daffinà, Julia, Izzo, Antonio, Zugaro, Luigi, Di Cesare, Ernesto, Barile, Antonio, and Arrigoni, Francesco
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- 2024
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12. Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
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Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, and Di Cesare Mannelli, Lorenzo
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- 2024
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13. Humanoid facial expressions as a tool to study human behaviour
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Lombardi, G., Sciutti, A., Rea, F., Vannucci, F., and Di Cesare, G.
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- 2024
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14. Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes
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Nakakana, Usman, Serry-Bangura, Alimamy, Edem, Bassey Effiom, Tessitore, Pietro, Di Cesare, Leonardo, Moriel, Danilo Gomes, Podda, Audino, De Ryck, Iris Sarah, and Arora, Ashwani Kumar
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- 2024
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15. Retraction Note: Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
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D’Antongiovanni, Vanessa, Pellegrini, Carolina, Benvenuti, Laura, Fornai, Matteo, Di Salvo, Clelia, Natale, Gianfranco, Ryskalin, Larisa, Bertani, Lorenzo, Lucarini, Elena, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Nemeth, Zoltan H., Haskó, György, and Antonioli, Luca
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- 2024
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16. Gender disparity in access to advanced therapies for patients with Parkinson’s disease: a retrospective real-word study
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Giuseppe Maccarrone, Gennaro Saporito, Patrizia Sucapane, Chiara Rizi, Federico Bruno, Alessia Catalucci, Maria Letizia Pistoia, Alessandra Splendiani, Alessandro Ricci, Ernesto Di Cesare, Marina Rizzo, Rocco Totaro, and Francesca Pistoia
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Parkinson’s disease ,MRgFUS ,DBS ,apomorphine ,Duodopa ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundGender differences in the access to advanced therapies for Parkinson’s disease (PD) are poorly investigated.ObjectiveThe objective of this study was to investigate the presence of any gender disparity in the access to advanced therapies for PD.DesignRetrospective study.MethodsData from patients with consistent access to the Parkinson’s and Movement Disorder Center of L’Aquila over the last 10-year period were screened. Patients selected for advanced therapies were included.ResultsOut of 1,252 patients, 200 (mean age ± SD 71.02 ± 9.70; 72% males; median Hoen Yahr level: 3, minimum 1 maximum 5) were selected for advanced therapies: 133 for Magnetic Resonance guided Focused Ultrasound (MRgFUS) thalamotomy (mean age ± SD 70.0 ± 8.9; 77% males), 49 for Levodopa/Carbidopa Intestinal Gel (LCIG) infusion (mean age ± SD 74.3 ± 11.4; 59% males), 12 for Deep Brain Stimulation (DBS) (mean age ± SD 71.2 ± 6.3; 75% males), and 7 for Continuous Subcutaneous Apomorphine Infusion (CSAI) (mean age ± SD 69.7 ± 5.5; 43% males). No sex differences were found in relation to age (MRgFUS group: males vs. females 70.2 ± 8.9 vs. 70.8 ± 8.9, p-value = 0.809; LCIG group: males vs. females 73.5 ± 13.0 vs. 75.5 ± 8.5, p-value = 0.557; DBS group: males vs. females 77.2 ± 8.1 vs. 67.3 ± 8.6, p-value = 0.843; CSAI group: males vs. females 73.3 ± 4.0 vs. 67.0 ± 5.2, p-value = 0.144) and disease duration (MRgFUS group: males vs. females 8.3 ± 4.4 vs. 9.6 ± 6.7, p-value = 0.419; LCIG group: males vs. females 14.5 ± 5.81 vs. 17.3 ± 5.5; p-value = 0.205; DBS group: males vs. females 15.0 ± 9.6 vs. 15.5 ± 7.7, p-value = 0.796; CSAI group: males vs. females 11.7 ± 3.7 vs. 10.3 ± 3.7, p-value = 0.505).ConclusionThe predominance of males is higher than that expected based on the higher prevalence of PD in men. Women are less confident in selecting advanced therapies during the natural progression of their disease. Factors accounting for this discrepancy deserve further investigation.
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- 2024
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17. Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study
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Elena Lucarini, Laura Benvenuti, Clelia Di Salvo, Vanessa D’Antongiovanni, Carolina Pellegrini, Giulia Valdiserra, Clara Ciampi, Luca Antonioli, Christian Lambiase, Lorenzo Cancelli, Antonio Grosso, Lorenzo Di Cesare Mannelli, Massimo Bellini, Carla Ghelardini, and Matteo Fornai
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irritable bowel syndrome ,colitis ,GABA ,Melissa officinalis ,abdominal pain ,Therapeutics. Pharmacology ,RM1-950 - Abstract
IntroductionVisceral pain represents the most common digestive issue, frequently resulting from long-term inflammation, such as inflammatory bowel diseases. The lack of effective drugs prompted search of new therapeutic approaches. In this regard, gamma-aminobutyric acid (GABA) and Melissa officinalis (Mo) appear as excellent candidates as they were recognized to have several positive effects on the digestive system. The aim of this research was to evaluate the effects of a compound containing GABA and Mo (GABA-Mo 5:1) in inflammation-induced intestinal damage and visceral pain.MethodsColitis was induced in rats by intrarectal 2,4-dinitrobenzenesulfonic acid (DNBS) administration. DNBS-treated animals received GABA-Mo (80 mg/kg BID), starting 3 days before DNBS administration, until 14 days after colitis induction (preventive protocol), or starting 7 days after DNBS until day 21 (curative protocol). Visceral pain was assessed by measuring the viscero-motor response (VMR) and the abdominal withdrawal reflex (AWR) to colorectal distension on day 7, 14 (both protocols) and 21 (curative protocol) after DNBS administration.ResultsIn the preventive protocol, GABA-Mo reduced AWR at day 14 but had no effect on VMR. In the spinal cord, treatment with GABA-Mo significantly prevented microglia reactivity (Iba-1 positive cells). In the colon, the supplement significantly decreased malondialdehyde (MDA, index of oxidative stress) and IL-1β levels and counteracted the decreased expression of claudin-1. Moreover, GABA-Mo normalized the increased levels of plasma lipopolysaccharide binding protein (LBP, index of altered intestinal permeability). In the curative protocol, GABA-Mo significantly counteracted visceral hypersensitivity persistence in DNBS-treated animals (day 14 and 21). In the spinal cord, GABA-Mo significantly reduced GFAP positive cell density (astrocytes). Histological evaluations highlighted a mild but significant effect of GABA-Mo in promoting healing from DNBS-induced colon damage. Colonic MDA and myeloperoxidase (index of leukocyte infiltration) levels were reduced, while the decreased colonic claudin-1 expression was normalized. In addition, the increased levels of plasma LBP were normalized by GABA-Mo administration.DiscussionIn conclusion GABA-Mo, particularly in the curative protocol, was able to reduce visceral pain and intestinal inflammation, likely through a reinforcement of intestinal barrier integrity, thus representing a suitable approach for the management of abdominal pain, especially in the remission stages of colitis.
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- 2024
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18. Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation
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Hugo R. Arias, Laura Micheli, Deborah Rudin, Ophelie Bento, Saskia Borsdorf, Clara Ciampi, Philippe Marin, Evgeni Ponimaskin, Dina Manetti, Maria Novella Romanelli, Carla Ghelardini, Matthias E. Liechti, and Lorenzo Di Cesare Mannelli
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Visceral pain ,neuropathic pain ,ibogalogs ,agonist and reverse agonist ,5-HT2A ,5-HT6 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The aim of this study was to determine the anti-hypersensitivity activity of novel non-hallucinogenic compounds derived from iboga alkaloids (i.e., ibogalogs), including tabernanthalog (TBG), ibogainalog (IBG), and ibogaminalog (DM506), using mouse models of neuropathic (Chronic Constriction Injury; CCI) and visceral pain (dextrane sulfate sodium; DSS). Ibogalogs decreased mechanical hyperalgesia and allodynia induced by CCI in a dose- and timeframe-dependent manner, where IBG showed the longest anti-hyperalgesic activity at a comparatively lower dose, whereas DM506 displayed the quickest response. These compounds also decreased hypersensitivity induced by colitis, where DM506 showed the longest activity. To understand the mechanisms involved in these effects, two approaches were utilized: ibogalogs were challenged with the 5-HT2A receptor antagonist ketanserin and the pharmacological activity of these compounds was assessed at the respective 5-HT2A, 5-HT6, and 5-HT7 receptor subtypes. The behavioral results clearly demonstrated that ketanserin abolishes the pain-relieving activity of ibogalogs without inducing any effect per se, supporting the concept that 5-HT2A receptor activation, but not inhibition, is involved in this process. The functional results showed that ibogalogs potently activate the 5-HT2A and 5-HT6 receptor subtypes, whereas they behave as inverse agonists (except TBG) at the 5-HT7 receptor. Considering previous studies showing that 5-HT6 receptor inhibition, but not activation, and 5-HT7 receptor activation, but not inhibition, relieved chronic pain, we can discard these two receptor subtypes as participating in the pain-relieving activity of ibogalogs. The potential involvement of 5-HT2B/2 C receptor subtypes was also ruled out. In conclusion, the anti-hypersensitivity activity of ibogalogs in mice is mediated by a mechanism involving 5-HT2A receptor activation.
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- 2024
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19. Plant species influences the composition of root system microbiome and its antibiotic resistance profile in a constructed wetland receiving primary treated wastewater
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Valentina Riva, Lorenzo Vergani, Ahmed Ali Rashed, Aiman El Saadi, Raffaella Sabatino, Andrea Di Cesare, Elena Crotti, Francesca Mapelli, and Sara Borin
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phytodepuration ,plant-microbe interactions ,water reuse ,Phragmites australis ,Typha domingensis ,antibiotic resistance genes ,Microbiology ,QR1-502 - Abstract
IntroductionConstructed wetlands (CWs) are nature-based solutions for wastewater treatment where the root system microbiome plays a key role in terms of nutrient and pollutant removal. Nonetheless, little is known on plant-microbe interactions and bacterial population selection in CWs, which are mostly characterized in terms of engineering aspects.MethodsHere, cultivation-independent and cultivation-based analyses were applied to study the bacterial communities associated to the root systems of Phragmites australis and Typha domingensis co-occurring in the same cell of a CW receiving primary treated wastewaters.Results and discussionTwo endophytic bacteria collections (n = 156) were established aiming to find novel strains for microbial-assisted phytodepuration, however basing on their taxonomy the possible use of these strains was limited by their low degrading potential and/or for risks related to the One-Health concept. A sharp differentiation arose between the P. australis and T. domingensis collections, mainly represented by lactic acid bacteria (98%) and Enterobacteriaceae (69%), respectively. Hence, 16S rRNA amplicon sequencing was used to disentangle the microbiome composition in the root system fractions collected at increasing distance from the root surface. Both the fraction type and the plant species were recognized as drivers of the bacterial community structure. Moreover, differential abundance analysis revealed that, in all fractions, several bacteria families were significantly and differentially enriched in P. australis or in T. domingensis. CWs have been also reported as interesting options for the removal of emerging contaminants (e.g, antibiotic resistance genes, ARGs). In this study, ARGs were mostly present in the rhizosphere of both plant species, compared to the other analyzed fractions. Notably, qPCR data showed that ARGs (i.e., ermB, blaTEM, tetA) and intl1 gene (integrase gene of the class 1 integrons) were significantly higher in Phragmites than Typha rhizospheres, suggesting that macrophyte species growing in CWs can display a different ability to remove ARGs from wastewater. Overall, the results suggest the importance to consider the plant-microbiome interactions, besides engineering aspects, to select the most suitable species when designing phytodepuration systems.
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- 2024
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20. Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
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Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, and Lorenzo Di Cesare Mannelli
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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21. Paratesticular Extramedullary Hematopoiesis in Children
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Kuhn, Elisabetta, Runza, Letterio, Di Cesare, Antonio, and Gianelli, Umberto
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Medical research ,Medicine, Experimental ,Pediatrics ,B cells ,Children -- Health aspects ,Health - Abstract
Context.--Extramedullary hematopoiesis (EMH) is an uncommon occurrence, usually associated with hematologic disorders, but it rarely presents as an isolated finding. Objective.--To determine the frequency, immunomorphologic features, and clinicopathologic background of EMH in orchiectomies from pediatric patients. Design.--All orchiectomy specimens removed from children from 2008 to 2020 in our institution were retrospectively reviewed. Biopsies and neoplasias were excluded. The EMH diagnosis was rendered when hematopoietic cell precursors were present. Immunohistochemical stainings were performed to characterize the hematopoietic components. Results.--Seventy-nine orchiectomies from 77 children (mean age, 5 years; range, 0-17 years) were included in our study. Forty-three patients (55.8%) underwent surgery for testicular atrophy, 30 (39.0%) for torsion, and 4 (5.2%) for intersex conditions. EMH was identified in 6 of 79 orchiectomies (7.6%), all performed for testicular torsion. All patients but one were newborns, and the remaining patient was 15 years old. No patient had evidence of a hematologic disorder. All EMH foci were in a background of reactive changes with a variable extension, either in the epididymis (4 cases) or in the deferens duct (2 cases). Immunostaining confirmed an association of myeloid ([myeloperoxidase.sup.+]) and erythroid precursors ([E-cadherin.sup.+]) in all 6 cases. One case also presented rare megakaryocytes, and one showed benign [TdT.sup.+] B-cell precursors. Conclusions.--To our knowledge, this is the first study that demonstrates EMH as a common finding in orchiectomy samples, especially from newborns. Despite the lack of pathologic potential, it is important to recognize EMH in order to avoid misdiagnosis. doi: 10.5858/arpa.2022-0135-OA, During a lifetime, hematopoietic sites progressively change. Specifically, physiological hematopoiesis begins in the yolk sac in the embryo phase, passes to the liver and spleen during the fetal second trimester, [...]
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- 2023
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22. Identifying simultaneously hyper-viscoelastic parameters from a unique heterogenous relaxation test: application to engineering elastomeric materials
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Tayeb, Adel, Di Cesare, Noëlie, Lu, Yaodong, Sales, Leonardo, Bastos, Guilherme, and Le Cam, Jean-Benoît
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- 2023
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23. Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes
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Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, and Ashwani Kumar Arora
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or advance following repeated episodes of acute rheumatic fever, causing rheumatic heart disease. Acute rheumatic fever and rheumatic heart disease disproportionately affect children and young adults in developing countries and disadvantaged communities in developed countries. People living with rheumatic heart disease are at risk of experiencing potentially fatal complications such as heart failure, bacterial endocarditis or stroke. Transthoracic echocardiography plays a central role in diagnosing both rheumatic carditis and rheumatic heart disease. Despite the obvious medical need, no licensed Strep A vaccines are currently available, as their clinical development process faces several challenges, including concerns for cardiac safety. However, the development of Strep A vaccines has been recently relaunched by many vaccine developers. In this context, a reliable and consistent safety evaluation of Strep A vaccine candidates, including the use of transthoracic echocardiography for detecting cardiac adverse events, could greatly contribute to developing a safe and efficacious product in the near future. Here, we propose a framework for the consistent use of transthoracic echocardiography to proactively detect cardiac safety events in clinical trials of Strep A vaccine candidates.
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- 2024
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24. Assessment of Voice Disorders Using Machine Learning and Vocal Analysis of Voice Samples Recorded through Smartphones
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Michele Giuseppe Di Cesare, David Perpetuini, Daniela Cardone, and Arcangelo Merla
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voice analysis ,voice disorders ,machine learning (ML) ,health monitoring ,early diagnosis ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Background: The integration of edge computing into smart healthcare systems requires the development of computationally efficient models and methodologies for monitoring and detecting patients’ healthcare statuses. In this context, mobile devices, such as smartphones, are increasingly employed for the purpose of aiding diagnosis, treatment, and monitoring. Notably, smartphones are widely pervasive and readily accessible to a significant portion of the population. These devices empower individuals to conveniently record and submit voice samples, thereby potentially facilitating the early detection of vocal irregularities or changes. This research focuses on the creation of diverse machine learning frameworks based on vocal samples captured by smartphones to distinguish between pathological and healthy voices. Methods: The investigation leverages the publicly available VOICED dataset, comprising 58 healthy voice samples and 150 samples from voices exhibiting pathological conditions, and machine learning techniques for the classification of healthy and diseased patients through the employment of Mel-frequency cepstral coefficients. Results: Through cross-validated two-class classification, the fine k-nearest neighbor exhibited the highest performance, achieving an accuracy rate of 98.3% in identifying healthy and pathological voices. Conclusions: This study holds promise for enabling smartphones to effectively identify vocal disorders, offering a multitude of advantages for both individuals and healthcare systems, encompassing heightened accessibility, early detection, and continuous monitoring.
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- 2024
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25. Humanoid Attitudes Influence Humans in Video and Live Interactions
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Fabio Vannucci, Giada Lombardi, Francesco Rea, Giulio Sandini, Giuseppe Di Cesare, and Alessandra Sciutti
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Action forms ,humanoid robots ,human-robot interaction ,social science ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
During social interactions, actions can be performed with different forms as a function of the mood driving them. These action forms i.e. vitality forms (VFs), have a strong influence in human interactions allowing people to immediately understand the attitude of others. Moreover, it has been demonstrated that the gentle and rude VFs expressed by a human agent influence the motor behavior of the receiver. An intriguing issue to investigate was to assess whether and how a humanoid agent, able to generate VFs, may induce the same contagion effect on the human partner. To this purpose we carried out a kinematic experiment investigating the motor behavior of participants in response to actions (taking request) performed by the iCub robot with different VFs in video and live interactive contexts. During the experiment, participants were required to pay attention to the iCub robot request and subsequently to place a ball on a specific target. Results indicate that: a) vitality forms conveyed by the iCub robot influenced the motor response of participants, modulating some kinematic parameters; b) this effect was obtained for both video and live interactive contexts; c) this effect was significantly greater in the video session compared to the live one.
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- 2024
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26. Humanoid facial expressions as a tool to study human behaviour
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G. Lombardi, A. Sciutti, F. Rea, F. Vannucci, and G. Di Cesare
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Medicine ,Science - Abstract
Abstract Besides action vitality forms, facial expressions represent another fundamental social cue which enables to infer the affective state of others. In the present study, we proposed the iCub robot as an interactive and controllable agent to investigate whether and how different facial expressions, associated to different action vitality forms, could modulate the motor behaviour of participants. To this purpose, we carried out a kinematic experiment in which 18 healthy participants observed video-clips of the iCub robot performing a rude or gentle request with a happy or angry facial expression. After this request, they were asked to grasp an object and pass it towards the iCub robot. Results showed that the iCub facial expressions significantly modulated participants motor response. Particularly, the observation of a happy facial expression, associated to a rude action, decreased specific kinematic parameters such as velocity, acceleration and maximum height of movement. In contrast, the observation of an angry facial expression, associated to a gentle action, increased the same kinematic parameters. Moreover, a behavioural study corroborated these findings, showing that the perception of the same action vitality form was modified when associated to a positive or negative facial expression.
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- 2024
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27. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis
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Roberto Cangemi, Valeria Raparelli, Giovanni Talerico, Stefania Basili, Francesco Violi, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davì Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Corazza Gino Roberto, Caldwell Stephen Hugh, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Proietti Marco, Raparelli Valeria, Romiti Giulio Francesco, Ruscio Eleonora, Severoni Andrea, Talerico Giovanni, Toriello Filippo, and Vestri Annarita
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Albumin ,Cirrhosis ,Portal Vein Thrombosis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aims: Hypoalbuminemia, as defined by serum albumin (SA) levels ≤35 g/L, is associated to venous and arterial thrombosis in general population and in patients at risk of cardiovascular disease. It is unknown if SA ≤35 g/L is also associated to portal vein thrombosis (PVT) in cirrhosis. Methods: Cirrhotic patients enrolled in the Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry (PRO-LIVER) study (n = 753), were followed-up for 2 years to assess the risk of PVT, that was diagnosed by Doppler ultrasonography. Child-Pugh classes, Model for End-Stage Liver Disease score, presence of hepatocellular carcinoma and laboratory variables including SA, D-dimer, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline. Results: SA ≤35 g/L was detected in 52% of patients. A logistic multivariate regression analysis showed that higher Child-Pugh class, hepatocellular carcinoma and thrombocytopenia were significantly associated to SA ≤35 g/L. In a subgroup of patients where data regarding hs-CRP and D-dimer were available, SA ≤35 g/L was inversely associated with hs-CRP and D-dimer. During the follow-up, a total of 61 patients experienced PVT. A Kaplan Meier survival analysis showed SA ≤35 g/L was associated to increased risk of PVT compared to SA >35 g/L (P = .005). A multivariate Cox proportional hazards regression analysis showed that male sex, lower platelet count, and SA ≤35 g/L remained associated to PVT after adjusting for confounding factors. Conclusion: Cirrhotic patients with SA ≤35 g/L are at higher risk of experiencing PVT compared to those with SA >35 g/L and could be considered as potential candidates to anticoagulant prophylaxis for PVT prevention.
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- 2024
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28. Comparison of gene targets and sampling regimes for SARS-CoV-2 quantification for wastewater epidemiology in UK prisons
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Kelly Jobling, Marcos Quintela-Baluja, Francis Hassard, Panagiota Adamou, Adrian Blackburn, Term Research Team, Shannon McIntyre-Nolan, Oscar O'Mara, Jesus L. Romalde, Mariachiara Di Cesare, and David W. Graham
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covid-19 ,health monitoring ,prisons ,rt-qpcr ,sars-cov-2 ,wastewater-based epidemiology ,Public aspects of medicine ,RA1-1270 - Abstract
Prisons are high-risk settings for infectious disease transmission, due to their enclosed and semi-enclosed environments. The proximity between prisoners and staff, and the diversity of prisons reduces the effectiveness of non-pharmaceutical interventions, such as social distancing. Therefore, alternative health monitoring methods, such as wastewater-based epidemiology (WBE), are needed to track pathogens, including SARS-CoV-2. This pilot study assessed WBE to quantify SARS-CoV-2 prevalence in prison wastewater to determine its utility within a health protection system for residents. The study analysed 266 samples from six prisons in England over a 12-week period for nucleoprotein 1 (N1 gene) and envelope protein (E gene) using quantitative reverse transcriptase-polymerase chain reaction. Both gene assays successfully detected SARS-CoV-2 fragments in wastewater samples, with both genes significantly correlating with COVID-19 case numbers across the prisons (p < 0.01). However, in 25% of the SARS-positive samples, only one gene target was detected, suggesting that both genes be used to reduce false-negative results. No significant differences were observed between 14- and 2-h composite samples, although 2-h samples showed greater signal variance. Population normalisation did not improve correlations between the N1 and E genes and COVID-19 case data. Overall, WBE shows considerable promise for health protection in prison settings. HIGHLIGHTS Wastewater epidemiology is effective in flagging COVID-19 cases in prison settings.; SARS-CoV-2 levels were quantified using N1 and E gene targets.; Both targets should be used in routine analysis to reduce false negatives.; COVID-19 case numbers significantly correlated with both wastewater gene targets across all samples.; Each prison is different – local activities are important when designing sampling programmes.;
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- 2024
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29. Evaluating the removal efficiency of emerging contaminants in a gravity-driven membrane bioreactors GD-MBR under various aeration conditions for primary wastewater treatment
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Yeong Na, Luigi Ranieri, Andrea Di Cesare, Raffaella Sabatino, Johannes Simon Vrouwenvelder, and Luca Fortunato
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Gravity-driven membrane (GMD) ,Biofilm ,Organic micropollutant ,Antibiotic-resistant gene ,Environmental engineering ,TA170-171 ,Chemical engineering ,TP155-156 - Abstract
Conventional wastewater treatment processes have shown limited efficiency in removing emerging contaminants (EC), including organic micropollutants (OMPs) thus posing risks due to the safe discharge and reuse of wastewater effluent due to the presence of antibiotic-resistant bacteria and antibiotic resistance genes (ARG). Membrane technologies are being considered as alternative wastewater treatment strategies. In this context, gravity-driven membrane bioreactors (GD-MBRs) has been highlighted as a sustainable treatment process due to the low energy consumption. This study evaluates the efficiency of GD-MBR in removing selected OMPs (sulfamethoxazole, carbamazepine, and diclofenac) and the impact on ARGs abundance during the treatment of raw primary wastewater. Three GD-MBRs were operated in parallel at the same time, under different aeration conditions (no aeration, continuous aeration, and intermittent aeration). The OMPs were dosed continuously for all reactors after 78 days of operations. Over time, the efficiency of OMP removal decreased in all reactors. Following the addition of OMPs, the relative abundance of ARGs increased in the membrane biofilms of all three reactors. The no aeration (NA) GD-MBR exhibited the highest removal efficiency for sulfamethoxazole up to 64 %, while exhibiting a higher increase in sulfonamide resistance genes with 2 gene copies/16S rRNA in the permeate on day 105. This study sheds light on the effectiveness of GD-MBRs in mitigating OMPs under varying aeration conditions, offering insights for wastewater treatment strategies using GD-MBR.
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- 2024
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30. Hygro-thermal coupling on 4D-printed biocomposites as key for meteosensitive shape-changing materials
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Melvin Josselin, Noëlie Di Cesare, Mickael Castro, Thibaut Colinart, Fabrizio Scarpa, and Antoine Le Duigou
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4D-printing ,biocomposite ,hygrothermal characterisation ,Science ,Manufactures ,TS1-2301 - Abstract
ABSTRACTHygromorph BioComposites (HBC) exhibit shape-changing actuated by a moisture content (MC) variation due to their bilayered bioinspired architecture. However, their application in daily meteorologic variation is limited due to relative humidity (RH) and thermal couplings. This work aims to investigate the role of temperature variation on the shape changing of 4D printed continuous flax fibres reinforced HBC so that ThermoHygromorph BioComposites (THBC) are introduced.The responsiveness of the THBC is governed by the MC of the material and the stiffness ratio between the passive and active layer, which are both thermally dependant. An increase in temperature strongly reduces the actuation amplitude while the actuation kinetics is strongly fastened. A 4D-printed HBC structure is designed and submitted to a practical outdoor environmental loading, to understand the impact of daily RH and temperature variations on THBC actuation.
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- 2024
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31. Staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of bilateral essential tremor and Parkinson’s disease related tremor: a systematic review and critical appraisal of current knowledge
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Simone Cesarano, Gennaro Saporito, Patrizia Sucapane, Federico Bruno, Alessia Catalucci, Maria Letizia Pistoia, Alessandra Splendiani, Alessandro Ricci, Ernesto Di Cesare, Rocco Totaro, and Francesca Pistoia
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MRgFUS ,tremor ,essential tremor ,Parkinson’s disease ,focused ultrasound ,thalamotomy ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionEssential tremor (ET) and Parkinson’s Disease (PD) are debilitating neurodegenerative disorders characterized by tremor as a predominant symptom, significantly impacting patients’ quality of life. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) Thalamotomy is an innovative therapeutic option for the treatment of unilateral medically refractory tremor with fewer adverse effects compared to traditional surgical interventions. A recent CE approval allows appropriate patients to have their second side treated.ObjectiveThe objective of this systematic review was to analyze available current knowledge about the use of MRgFUS for the treatment of bilateral ET and PD related tremor, to identify the effectiveness and the risks associated with bilateral treatment.MethodsEligible studies were identified by searching published studies in PubMed and Scopus databases from May 2014 to January 2024 and by identifying ongoing studies registered on the clinicaltrials.gov website. Data were summarized by considering the following information topics: the number of patients involved, the selected lesion target, the assessment tool used to evaluate clinical changes, the observed improvement, the reported side effects, and the time interval between the two treatments. The study was registered in PROSPERO (ID: CRD42024513178).ResultsNine studies were eligible for this review, 7 for ET and 2 for PD. The involved population included a variable number of patients, ranging from 1 to 11 subjects for ET and from 10 to 15 subjects for PD. The main lesional targets were the ventral intermediate nucleus of the thalamus, the pallidothalamic tract and the cerebellothalamic tract bilaterally. All studies investigated the tremor relief through the Clinical Rating Scale for Tremor (CRST) in patients with ET, and through the Unified Parkinson’s Disease Rating Scale (UPDRS) in patients with PD. A variable degree of improvement was observed, with all patients expressing overall satisfaction with the bilateral treatment. Adverse events were mild and transient, primarily involving gait disturbances, dysarthria, and ataxia. A standardized protocol for administering the two consecutive treatments was not identifiable; typically, the timing of the second treatment was delayed by at least 6 months.ConclusionAvailable evidence supports the effectiveness and safety of staged bilateral MRgFUS treatments for ET and PD-related tremor.
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- 2024
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32. Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study
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Gennaro Saporito, Patrizia Sucapane, Federico Bruno, Alessia Catalucci, Carlo Masciocchi, Maria Letizia Pistoia, Alessandra Splendiani, Alessandro Ricci, Ernesto Di Cesare, Carmine Marini, Monica Mazza, Rocco Totaro, and Francesca Pistoia
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tremor ,cognitive outcomes ,Parkinson disease ,essential tremor ,MRgFUS ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionIn the COGNitive in Focused UltraSound (COGNIFUS) study, we examined the 6-month cognitive outcomes of patients undergoing MRgFUS thalamotomy. This study endorsed the safety profile of the procedure in terms of cognitive functions that cannot be evaluated in real-time during the procedure unlike other aspects. The aim of the COGNIFUS Part 2 study was to investigate the cognitive trajectory of MRgFUS patients over a 1-year period, in order to confirm long-term safety and satisfaction.MethodsWe prospectively evaluated the cognitive and neurobehavioral profile of patients with essential tremor (ET) or Parkinson’s Disease (PD) related tremor undergoing MRgFUS thalamotomy at 1 year-follow-up following the treatment.ResultsThe sample consists of 50 patients (male 76%; mean age ± SD 69.0 ± 8.56; mean disease duration ± SD 12.13 ± 12.59; ET 28, PD 22 patients). A significant improvement was detected at the 1 year-follow-up assessment in anxiety and mood feelings (Hamilton Anxiety rating scale 5.66 ± 5.02 vs. 2.69 ± 3.76, p ≤
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- 2024
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33. Early re-emerging tremor after MRgFUS thalamotomy: case–control analysis of procedural and imaging features
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Federico Bruno, Pierfrancesco Badini, Antonio Innocenzi, Gennaro Saporito, Alessia Catalucci, Patrizia Sucapane, Antonio Barile, Ernesto Di Cesare, Carmine Marini, Francesca Pistoia, and Alessandra Splendiani
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essential tremor ,Parkinson’s disease ,MRgFUS ,MRI ,tremor recurrence ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
PurposeThis study aimed to identify possible prognostic factors determining early tremor relapse after Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) thalamotomy in patients with essential tremor (ET) and Parkinson’s disease (PD).MethodsNine patients (six ET and three PD) who underwent Vim MRgFUS thalamotomy in a single institution and developed early re-emergent tremor were analyzed. A control group of patients matched pairwise for sex, pathology, age, disease duration, and skull density ratio (SDR) was selected to compare the technical-procedural data and MR imaging evidence. MR imaging findings compared between groups included lesion shape and volume in multiparametric sequences, as well as Fractiona Anisotropy (FA) and Apparent Diffusion Coefficient (ADC) values derived from Diffusion Tensor Imaging Diffusion Weighted Imaging (DTI) and Diffusion Weighted Imaging (DWI) sequences.ResultsWe did not find statistically significant differences in gender and age between the two groups. Technical and procedural parameters were also similar in both treatment groups. In MRI analysis, we found lesions of similar size but with greater caudal extension in the control group with stable outcomes compared to patients with tremor relapse.ConclusionIn our analysis of early recurrences after thalamotomy with focused ultrasound, there were neither technical and procedural differences nor prognostic factors related to lesion size or ablation temperatures. Greater caudal extension of the lesion in patients without recurrence might suggest the importance of spatial consolidation during treatment.
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- 2024
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34. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
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Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkhatib, Buthaina M, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amougou, Norbert, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Bahijri, Suhad, Bajramovic, Izet, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Basit, Abdul, Bastos, Joao Luiz, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bettiol, Heloísa, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boggia, Jose G, Bogova, Elena, Bonaccio, Marialaura, Bonilla-Vargas, Alice, Borghs, Herman, Botomba, Steve, Bourne, Rupert, Boymatova, Khadichamo, Braeckman, Lutgart, Braithwaite, Tasanee, Brajkovich, Imperia, Branca, Francesco, Brenner, Hermann, Brewster, Lizzy M, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brug, Johannes, Bugge, Anna, Buntinx, Frank, Buoncristiano, Marta, Burns, Con, Cabrera de León, Antonio, Caixeta, Roberta B, Cama, Tilema, Can, Günay, Cândido, Ana Paula C, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Casanueva, Felipe F, Casas, Maribel, Censi, Laura, Cervantes‐Loaiza, Marvin, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Queenie, Chaturvedi, Nish, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Chong, Chean Lin, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Cohen, Emmanuel, Confortin, Susana C, Coppinger, Tara C, Cortés, Lilia Yadira, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Cucu, Alexandra M, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dahm, Christina C, Dallongeville, Jean, Dankner, Rachel, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, de Paiva, Karina Mary, De Ridder, Karin, de Valois Correia Júnior, Marco Aurélio, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Donoso, Silvana P, Dorobantu, Maria, Dörr, Marcus, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka L, Dushpanova, Anar, Dyussupova, Azhar, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eghtesad, Sareh, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Esmaeili, Ali, Evans, Roger G, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrante, Daniel, Ferrari, Gerson, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galfo, Myriam, Garcia-de-la-Hera, Manoli, Garcia, Pablo, Garnett, Sarah P, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Goldberg, Marcel, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Gottrand, Frederic, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Grodzicki, Tomasz, Grøholt, Else Karin, Grøntved, Anders, Guajardo, Viviana, Guallar-Castillón, Pilar, Guerchet, Maëlenn, Guerrero, Ramiro, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunter, Marc J, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gurzkowska, Beata, Gutierrez, Laura, Gwee, Xinyi, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Heinen, Mirjam, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel O, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Huisman, Martijn, Husseini, Abdullatif, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iakupova, Ellina M, Iannone, Anna G, Igland, Jannicke, Ijoma, Chinwuba, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jaddou, Hashem Y, Jadoul, Michel, Jafar, Tazeen, Jan, Nataša, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jha, Anjani Kumar, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Juolevi, Anne, Juresa, Vesna, Jureša, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Karki, Khem B, Kassi Anicet, Adoubi, Katibeh, Marzieh, Katulanda, Prasad, Katzmarzyk, Peter T, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kersting, Mathilde, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Koussoh Simone, Malik, Kovács, Éva, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kyobutungi, Catherine, La, Quang Ngoc, Labadarios, Demetre, Lachat, Carl, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Landaeta Jimenez, Maritza, Landais, Edwige, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Lateva, Mina P, Latt, Tint Swe, Laurenzi, Martino, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, Le Nguyen Bao, Khanh, Lehtimäki, Terho, Lemogoum, Daniel, Leong, Elvynna, Leszczak, Justyna, Leung, Gabriel M, Li, Yanping, Liivak, Merike, Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lind, Lars, Litwin, Mieczyslaw, Liu, Liping, Liu, Xiaotian, Longo Abril, Guadalupe, Lopes, Oscar, Lopez-Garcia, Esther, López-Gil, José Francisco, Lopez, Tania, Lozano, José Eugenio, Lukrafka, Janice L, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lunogelo, Charles, Lustigová, Michala, M'Buyamba-Kabangu, Jean-René, Machado-Coelho, George LL, Machado-Rodrigues, Aristides M, Macia, Enguerran, Madar, Ahmed A, Maestre, Gladys E, Maggi, Stefania, Magliano, Dianna J, Magnacca, Sara, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Makdisse, Marcia, Malekpour, Mohammad-Reza, Malekzadeh, Fatemeh, Malekzadeh, Reza, Mallikharjuna Rao, Kodavanti, Malyutina, Sofia, Maniego, Lynell V, Manios, Yannis, Mann, Jim I, Mansour-Ghanaei, Fariborz, Manzato, Enzo, Mapatano, Mala Ali, Maria-Magdalena, Rosu, Mariño, Joany, Markaki, Anastasia, Marques, Larissa Pruner, Marrugat, Jaume, Martorell, Reynaldo, Maruszczak, Katharina, Masala, Giovanna, Mascarenhas, Luis P, Masimango Imani, Mannix, Masinaei, Masoud, Mathiesen, Ellisiv B, Matijasevich, Alicia, Matłosz, Piotr, Matsha, Tandi E, Matsudo, Victor, Matteo, Giletta, Maulik, Pallab K, Mavrogianni, Christina, Mc Donald Posso, Anselmo J, McFarlane, Shelly R, McLean, Rachael M, Mediene Benchekor, Sounnia, Mehlig, Kirsten, Mehrparvar, Amir Houshang, Melgarejo, Jesus D, Méndez, Fabián, Mendivil, Carlos O, Mendoza Montano, Carlos, Menezes, Ana Maria B, Mensink, Gert BM, Mereke, Alibek, Meshram, Indrapal I, Meto, Diane T, Meyer, Haakon E, Mi, Jie, Miłkowska, Karolina, Miller, Jody C, Milushkina, Olga, Minderico, Cláudia S, Mini, GK, Miquel, Juan Francisco, Miranda, J Jaime, Mirjalili, Mohammad Reza, Mišigoj-Duraković, Marjeta, Mistretta, Antonio, Mocanu, Veronica, Modesti, Pietro A, Moghaddam, Sahar Saeedi, Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohan, Viswanathan, Mohd Yusoff, Muhammad Fadhli, Mohebbi, Iraj, Møller, Niels C, Molnár, Dénes, Momenan, Amirabbas, Mondo, Charles K, Monroy-Valle, Michele M, Montenegro Mendoza, Roger A, Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moosazadeh, Mahmood, Moradpour, Farhad, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Moslem, Alireza, Mosquera, Mildrey, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Motlagh, Mohammad Esmaeel, Motta, Jorge, Moura-dos-Santos, Marcos André, Mridha, Malay K, Msyamboza, Kelias P, Mu, Thet Thet, Muca, Florian, Mugoša, Boban, Munroe, Patricia B, Mursu, Jaakko, Musa, Kamarul Imran, Musić Milanović, Sanja, Musil, Vera, Musinguzi, Geofrey, Mustafa, Norlaila, Muyer, Muel Telo Marie-Claire, Nabipour, Iraj, Naidu, Balkish M, Najafi, Farid, Nalecz, Hanna, Námešná, Jana, Narayan, KM Venkat, Naseri, Take, Nathalie, Michels, Neelapaichit, Nareemarn, Nejatizadeh, Azim, Nenko, Ilona, Nervi, Flavio, Neuhauser, Hannelore K, Ng, Tze Pin, Nguyen, Chung T, Nguyen, Quang V, Nguyen, Quang Ngoc, Ni, Michael Y, Nie, Peng, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ninomiya, Toshiharu, Nishi, Nobuo, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Nogueira, Helena, Norton, Kevin I, Noto, Davide, Nowak-Szczepanska, Natalia, Nsour, Mohannad Al, Nuhoğlu, Irfan, Nurk, Eha, Nuwaha, Fred, Nyirenda, Moffat, O'Neill, Terence W, Ochimana, Caleb, Ochoa-Avilés, Angélica M, Oda, Eiji, Odili, Augustine N, Oh, Kyungwon, Ohtsuka, Ryutaro, Oldenburg, Brian, Olié, Valérie, Omar, Mohd Azahadi, Omar, Saeed M, Onat, Altan, Ong, Sok King, Onland-Moret, N Charlotte, Ono, Lariane M, Onodugo, Obinna, Ordunez, Pedro, Ornelas, Rui, Ortiz, Ana P, Ortiz, Pedro J, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Ottendahl, Charlotte B, Otu, Akaninyene, Overvad, Kim, Owusu-Dabo, Ellis, Padez, Cristina P, Pagkalos, Ioannis, Pajula, Natalja, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panza, Francesco, Paoli, Mariela, Papadopoulou, Sousana K, Pareja, Rossina G, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R, Parsaeian, Mahboubeh, Pascanu, Ionela M, Pasquet, Patrick, Patel, Nikhil D, Pavlyshyn, Halyna, Pechlaner, Raimund, Pećin, Ivan, Pedro, João M, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peres, Karen GDA, Peres, Marco A, Perez-Londoño, Agustín, Pérez, Cynthia M, Peterkova, Valentina, Petrovna Kovtun, Olga, Peykari, Niloofar, Pham, Son Thai, Pichardo, Rafael N, Pierre-Marie, Preux, Pikhart, Hynek, Pilav, Aida, Piler, Pavel, Piwonska, Aleksandra, Pizarro, Andreia N, Plata, Silvia, Pop, Raluca M, Popkin, Barry M, Popovic, Stevo R, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J, Prista, Antonio, Providencia, Rui, Puder, Jardena J, Pudule, Iveta, Puhakka, Soile, Puiu, Maria, Punab, Margus, Qorbani, Mostafa, Quialheiro, Anna, Quintana, Hedley K, Quiroga-Padilla, Pedro J, Quoc Bao, Tran, Rach, Stefan, Rahimikazerooni, Salar, Rahman, Mahmudur, Raitakari, Olli, Rakhmatulloev, Sherali, Rakovac, Ivo, Ramachandran, Ambady, Ramadan, Otim PC, Ramirez-Zea, Manuel, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Ramsay, Sheena E, Rangel Junior, João FLB, Rangel Reina, Daniel A, Rangelova, Lalka S, Rarra, Vayia, Rashidi, Mohammad-Mahdi, Rech, Cassiano Ricardo, Redon, Josep, Regecová, Valéria, Renner, Jane DP, Repasy, Judit A, Reuter, Cézane P, Revilla, Luis, Reynolds, Andrew, Rezaei, Negar, Rezaianzadeh, Abbas, Riboli, Elio, Rigo, Fernando, Rigotti, Attilio, Riley, Leanne M, Rinke de Wit, Tobias F, Risérus, Ulf, Ritti-Dias, Raphael M, Roa, Reina G, Roccaldo, Romana, Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rodríguez-Villamizar, Laura A, Rodríguez, Andrea Y, Roggenbuck, Ulla, Rohloff, Peter, Rojas-Martinez, Rosalba, Romeo, Elisabetta L, Rosario, Rafaela V, Rosengren, Annika, Rouse, Ian, Rubinstein, Adolfo, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Ruiz Moreno, Emma, Rusakova, Iuliia A, Rusek, Wojciech, Rust, Petra, Rutkowski, Marcin, Saamel, Marge, Sabbaghi, Hamideh, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salazar Martinez, Eduardo, Salkhanova, Akkumis, Salonen, Jukka T, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Santos, Diana A, Santos, Ina S, Santos, Maria Paula, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savin, Stefan, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Amand Floriaan, Schmidt, Börge, Schmidt, Carsten O, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Sein, Aye Aye, Sen, Abhijit, Sepanlou, Sadaf G, Sequera, Guillermo, Ševčíková, Ľudmila, Sewpaul, Ronel, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shiri, Rahman, Shoranov, Marat, Shrestha, Namuna, Si-Ramlee, Khairil, Sibai, Abla M, Sidossis, Labros S, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Sjöström, Michael, Skoblina, Natalia A, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, Smith, Lee, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Soemantri, Agustinus, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sørgjerd, Elin P, Sorić, Maroje, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Spiroski, Igor, Staessen, Jan A, Stang, Andreas, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Sturua, Lela, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sulo, Gerhard, Sundström, Johan, Suriyawongpaisal, Paibul, Swinburn, Boyd A, Sylva, René Charles, Szponar, Lucjan, Tai, E Shyong, Tambalis, Konstantinos D, Tamosiunas, Abdonas, Tanabayev, Baimakhan, Tanrygulyyeva, Maya, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Thankappan, KR, Theodoridis, Xenophon, Thirunavukkarasu, Sathish, Thomas, Nihal, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolstrup, Janne S, Topbas, Murat, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trivedi, Atul, Tshepo, Lechaba, Tsintavis, Panagiotis, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Turley, Maria L, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Vasan, Senthil K, Vasques, Daniel G, Vega, Tomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verdot, Charlotte, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Verstraeten, Roosmarijn, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Virtanen, Jyrki K, Visser, Marjolein, Viswanathan, Bharathi, Vladulescu, Mihaela, Völzke, Henry, Voutilainen, Ari, Vrijheid, Martine, Wade, Alisha N, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Webster-Kerr, Karen, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Westbury, Leo, Whincup, Peter H, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wilks, Rainford J, Willeit, Karin, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wu, Frederick C, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Li, Yan, Weili, Yang, Yang, Yépez García, Martha, Yoosefi, Moein, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusoff, Ahmad Faudzi, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zhang, Bing, Zhang, Zhen-Yu, Zhecheva, Yanitsa V, Zholdin, Bekbolat, Zimmet, Paul, Zins, Marie, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
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- 2024
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35. Anthropogenic pollution may enhance natural transformation in water, favouring the spread of antibiotic resistance genes
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Sivalingam, Periyasamy, Sabatino, Raffaella, Sbaffi, Tomasa, Corno, Gianluca, Fontaneto, Diego, Borgomaneiro, Giulia, Rogora, Michela, Crotti, Elena, Mapelli, Francesca, Borin, Sara, Pilar, Andrea Lopez, Eckert, Ester M., and Di Cesare, Andrea
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- 2024
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36. Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation
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Arias, Hugo R., Micheli, Laura, Rudin, Deborah, Bento, Ophelie, Borsdorf, Saskia, Ciampi, Clara, Marin, Philippe, Ponimaskin, Evgeni, Manetti, Dina, Romanelli, Maria Novella, Ghelardini, Carla, Liechti, Matthias E., and Di Cesare Mannelli, Lorenzo
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- 2024
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37. Pathophysiological Link Between Chronic Rhinosinusitis and Ear Disease
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Calvo-Henriquez, Christian, Di Corso, Eugenio, Alobid, Isam, Cantone, Elena, Di Cesare, Tiziana, and Mullol, Joaquim
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- 2023
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38. Pharmacokinetics of dexmedetomidine in anaesthetized horses following repeated subcutaneous administration and intravenous constant rate infusion
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Federica Di Cesare, Vanessa Rabbogliatti, Susanna Draghi, Martina Amari, Federica Alessandra Brioschi, Roberto Villa, Giuliano Ravasio, and Petra Cagnardi
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Balanced anaesthesia ,Constant rate infusion ,Dexmedetomidine ,Equine patient ,Liquid Chromatography Mass Spectrometry ,Pharmacokinetics ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background The inclusion of dexmedetomidine (DEX) within a balanced general anaesthesia protocol is effective in improving the clinical outcome and recovery quality of anaesthesia in horses. This study aimed to determine the pharmacokinetic profile of DEX following repeated subcutaneous (SC) administration at 2 µg/kg every 60 min till the end of the procedure in comparison to intravenous constant rate infusion (CRI) at 1 µg/kg/h in anaesthetized horses undergoing diagnostic procedures up to the end of the diagnostic procedure. Results In the CRI and SC groups DEX maximum concentrations (Cmax) were 0.83 ± 0.27 ng/mL and 1.14 ± 0.71 ng/mL, respectively, reached at a time (Tmax) of 57.0 ± 13.4 min and 105.5 ± 29.9 min. Mean residence time to the last measurable concentration (MRTlast) was 11.7 ± 6.2 and 55.8 ± 19.7 min for the CRI group and SC groups, respectively. The apparent elimination half-life was 18.0 ± 10.0 min in the CRI group and 94.8 ± 69.8 min for the SC group, whereas the area under the curve (AUC0-last) resulted 67.7 ± 29.3 and 83.2 ± 60.5 min*ng/mL for CRI and SC group, respectively. Clearance was 16.26 ± 8.07 mL/min/kg for the CRI group. No signs of adverse effects were recorded in both groups. Conclusions The pharmacokinetic profile of DEX following repeated SC administration in anaesthetized horses was comparable to intravenous CRI administration during the intranaesthetic period and beneficial during the recovery phase from general anaesthesia. The SC route could be considered as an alternative to CRI for improving the recovery quality of equine patients undergoing general anaesthesia.
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- 2023
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39. Author Correction: Humanoid facial expressions as a tool to study human behaviour
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G. Lombardi, A. Sciutti, F. Rea, F. Vannucci, and G. Di Cesare
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Medicine ,Science - Published
- 2024
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40. Use of Hair as Matrix for Trace Elements Biomonitoring in Cattle and Roe Deer Sharing Pastures in Northern Italy
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Susanna Draghi, Nour Elhouda Fehri, Fatma Ateş, Nural Pastacı Özsobacı, Duygu Tarhan, Bengü Bilgiç, Banu Dokuzeylül, Çağla Parkan Yaramış, Alev Meltem Ercan, Mehmet Erman Or, Petra Cagnardi, Gabriele Brecchia, Giulio Curone, and Federica Di Cesare
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bioindicators ,eco-toxicology ,environmental toxicology ,PTEs ,wildlife ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Intensive cattle breeding’s environmental challenges are prompting shifts to extensive, pasture-based systems, influencing nutrient and pollutant uptake. PTEs are essential and non-essential elements, regularly found in the environment and organisms, and in which unbalances lead to health issues. Hair analysis, a non-invasive method, provides retrospective PTE exposure evaluation. This study aims to understand exposure and species-specific accumulation patterns of PTEs in cattle and roe deer sharing pastures in Northern Italy using the hair analysis. Aluminum, As, Cd, Cr, Ni, Pb, Cu, Mg, Fe, and Zn were quantified through the use of ICP-OES. Findings show As levels significantly higher in roe deer due to their selective feeding, while Cd and Pb levels align with other studies. Essential elements like Cu, Fe, and Zn are lower in cattle, possibly due to diet differences. Higher Cr and Ni levels in cattle suggest contamination or physiological differences in accumulation patterns. In conclusion, hair analysis is valuable for monitoring environmental PTE exposure, highlighting significant interspecies differences and the potential of both animals as bioindicators in shared grazing areas.
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- 2024
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41. IPINeT Ped-unPAD Study: Goals, Design, and Preliminary Results
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Mayla Sgrulletti, Lucia Augusta Baselli, Riccardo Castagnoli, Elisabetta Del Duca, Simona Graziani, Giusella Maria Francesca Moscato, Silvia Di Cesare, Gigliola Di Matteo, Cristina Cifaldi, Martina Rossano, Claudia Ballerini, Alfonso Piciocchi, Amelia Licari, Gian Luigi Marseglia, Rita Consolini, and Viviana Moschese
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children ,common variable immunodeficiency ,inborn errors of immunity ,primary antibody deficiency ,transient hypogammaglobulinemia of infancy ,unclassified primary antibody deficiency ,Medicine - Abstract
Background: An unclassified primary antibody deficiency (unPAD) is a widely heterogeneous clinical entity, recently identified within the spectrum of Inborn Errors of Immunity (IEIs). Since unPAD has been traditionally considered as a mild condition, it has incorrectly received little attention, resulting in the paucity of extensive and comparable studies describing its natural history. To address the gaps in characterizing, understanding, and managing pediatric unPAD patients, the Italian Primary Immunodeficiency Network (IPINet) Ped-unPAD study has recently been launched. Methods: Seventeen IPINeT Centers have expressed interest to participate, and data collection is still on-going. Hereby, we anticipate preliminary key issues emerging from the first 110 enrolled patients, attending three IPINet Centers. Results: A proportion of unPAD patients have experienced a severe infectious phenotype, which required hospitalization in a quarter of patients and antibiotic prophylaxis or Immunoglobulin Replacement Therapy in approximately 10% of patients. In this partial cohort, a mean follow-up (FU) of 5 years confirmed unPAD diagnosis in fifty percent of cases, with the remaining being reclassified as the Transient Hypogammaglobulinemia of Infancy (25%) and other IEIs (25%), such as a Common Variable Immunodeficiency, Selective IgA deficiency, Selective IgM deficiency, and IgG3 subclass deficiency. Conclusions: Despite a phenotype overlap at diagnosis, clinicians should be aware that unPAD is a mutable condition that deserves comprehensive evaluation and long-term monitoring to dissect the final diagnosis for optimal treatment.
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- 2024
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42. Dupilumab Improves Facial Pain and Reduces Rescue Treatments in Patients with CRSwNP and Recalcitrant Frontal Sinusitis
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Eugenio De Corso, Stefano Settimi, Daniele Penazzi, Giuseppe D’Agostino, Marco Corbò, Mario Rigante, Claudio Montuori, Alberta Rizzuti, Maria Clara Pacilli, Tiziana Di Cesare, Simone Lo Verde, Angela Rizzi, Raffaella Chini, and Jacopo Galli
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chronic rhinosinusitis ,nasal polyps ,biologics ,endoscopic sinus surgery ,frontal sinusitis ,headache ,Medicine - Abstract
Recalcitrant frontal sinusitis in patients with chronic rhinosinusitis and nasal polyps (CRSwNP) has a negative impact on their quality of life due to frontal pain and a high risk of sinus occlusion, thus necessitating antibiotics, systemic corticosteroids, and multiple surgeries. The aim of this study was to assess the efficacy of dupilumab in reducing frontal pain and the need for rescue treatments for recalcitrant frontal sinusitis in patients with CRSwNP. We enrolled a cohort of 10 patients with severe uncontrolled CRSwNP and concomitant recurrent frontal sinusitis associated with severe facial pain measured by MIDAS score who were treated with dupilumab 300 mg every 2 weeks and followed for at least 12 months. The mean MIDAS score decreased from 45.6 ± 10.7 at baseline to 1.3 ± 2.3 at 6 months (p < 0.05). VAS craniofacial pain decreased from 7.3 ± 1.6 at baseline to 1.2 ± 1.5 at 6 months (p < 0.05). No patient needed oral corticosteroids during treatment with dupilumab (p < 0.05), and the use of analgesics decreased from 9.6 ± 3.1 NSAID pills/week in the last 2 months at baseline to 0.6 ± 1.3 at 1 year of follow-up (p < 0.05). Our results demonstrated that use of subcutaneous dupilumab can improve symptom control, including recurrent severe cranio-facial pain, and reduce the need for rescue medical treatments (systemic steroids and NSAID) in patients with severe uncontrolled CRSwNP and concomitant recurrent frontal sinusitis.
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- 2024
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43. Correction: Micheli et al. Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation. Nutrients 2020, 12, 1819
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Laura Micheli, Alessandra Pacini, Lorenzo Di Cesare Mannelli, Elena Trallori, Roberta D’Ambrosio, Carlo Bianchini, Pietro Lampertico, and Carla Ghelardini
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n/a ,Nutrition. Foods and food supply ,TX341-641 - Abstract
In the original publication [...]
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- 2024
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44. Seropositivity for Toxoplasma gondii in cats with clinical signs and living in households with women of childbearing age
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Traversa, Donato, Morelli, Simone, Di Cesare, Angela, Colombo, Mariasole, Iorio, Raffaella, Pagliaccia, Alessandra, Catalano, Cecilia, Paoletti, Barbara, and Brueckmann, Roberto
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- 2024
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45. Treated wastewater: A hotspot for multidrug- and colistin-resistant Klebsiella pneumoniae
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Di Cesare, Andrea, Cornacchia, Alessandra, Sbaffi, Tomasa, Sabatino, Raffaella, Corno, Gianluca, Cammà, Cesare, Calistri, Paolo, and Pomilio, Francesco
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- 2024
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46. The integration of omics and cultivation-dependent methods could effectively determine the biological risks associated with the utilization of soil conditioners in agriculture
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Peruzzo, Arianna, Petrin, Sara, Boscolo Anzoletti, Aurora, Mancin, Marzia, Di Cesare, Andrea, Sabatino, Raffaella, Lavagnolo, Maria Cristina, Beggio, Giovanni, Baggio, Giulia, Danesi, Patrizia, Barco, Lisa, and Losasso, Carmen
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- 2024
- Full Text
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47. Clinical efficacy of a parasiticide formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard® Combo) in the treatment of natural feline aelurostrongylosis and troglostrongylosis
- Author
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Di Cesare, Angela, Veronesi, Fabrizia, Crisi, Paolo Emidio, Colombo, Mariasole, Morelli, Simone, Vignoli, Massimo, Rigamonti, Giulia, Iorio, Raffaella, Tielemans, Eric, Beugnet, Frederic, Gamblin, Camille, and Traversa, Donato
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- 2024
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48. Parity in bacterial communities and resistomes: Microplastic and natural organic particles in the Tyrrhenian Sea
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Di Cesare, Andrea, Sathicq, Maria Belen, Sbaffi, Tomasa, Sabatino, Raffaella, Manca, Dario, Breider, Florian, Coudret, Sylvain, Pinnell, Lee J., Turner, Jeffrey W., and Corno, Gianluca
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- 2024
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49. Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
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Nobili, Stefania, Micheli, Laura, Lucarini, Elena, Toti, Alessandra, Ghelardini, Carla, and Di Cesare Mannelli, Lorenzo
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- 2024
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50. Genotyping USA laboratory-maintained isolates and European clinical isolates of Dirofilaria immitis to assess macrocyclic lactone susceptibility or resistance at predictive SNP sites using droplet digital PCR
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Kumar, Sohini, Che, Hua, Chiummo, Rafael, Heuer, Lea, Schneider, Carolin, Werr, Margaret, Guerino, Frank, Papadopolous, Elias, Diakou, Anastasia, Mihalca, Andrei Daniel, Traversa, Donato, Di Cesare, Angela, Long, Thavy, and Prichard, Roger K.
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- 2024
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