Search

Your search keyword '"Devor, Anna"' showing total 275 results
Start Over Author "Devor, Anna" Language english
275 results on '"Devor, Anna"'

5. A suite of neurophotonic tools to underpin the contribution of internal brain states in fMRI

Author

Mächler, Philipp, Broggini, Thomas, Mateo, Celine, Thunemann, Martin, Fomin-Thunemann, Natalie, Doran, Patrick R., Sencan, Ikbal, Kilic, Kivilcim, Desjardins, Michèle, Uhlirova, Hana, Yaseen, Mohammad A., Boas, David A., Linninger, Andreas A., Vergassola, Massimo, Yu, Xin, Lewis, Laura D., Polimeni, Jonathan R., Rosen, Bruce R., Sakadžić, Sava, Buxton, Richard B., Lauritzen, Martin, Kleinfeld, David, and Devor, Anna

Published
2021
Full Text
View/download PDF

6. Widefield in vivo imaging system with two fluorescence and two reflectance channels, a single sCMOS detector, and shielded illumination.

Author

Doran, Patrick R., Fomin-Thunemann, Natalie, Tang, Rockwell P., Balog, Dora, Zimmerman, Bernhard, Kılıç, Kıvılcım, Martin, Emily A., Kura, Sreekanth, Fisher, Harrison P., Chabbott, Grace, Herbert, Joel, Rauscher, Bradley C., Jiang, John X., Sakadzic, Sava, Boas, David A., Devor, Anna, Chen, Ichun Anderson, and Thunemann, Martin

Subjects
IMAGING systems, FLUORESCENT probes, MESOSCOPIC systems, DEOXYHEMOGLOBIN, DIODES
Abstract

Significance: Widefield microscopy of the entire dorsal part of mouse cerebral cortex enables large-scale ("mesoscopic") imaging of different aspects of neuronal activity with spectrally compatible fluorescent indicators as well as hemodynamics via oxy- and deoxyhemoglobin absorption. Versatile and cost-effective imaging systems are needed for large-scale, color-multiplexed imaging of multiple fluorescent and intrinsic contrasts. Aim: We aim to develop a system for mesoscopic imaging of two fluorescent and two reflectance channels. Approach: Excitation of red and green fluorescence is achieved through epi-illumination. Hemoglobin absorption imaging is achieved using 525- and 625-nm lightemitting diodes positioned around the objective lens. An aluminum hemisphere placed between objective and cranial window provides diffuse illumination of the brain. Signals are recorded sequentially by a single sCMOS detector. Results: We demonstrate the performance of our imaging system by recording large-scale spontaneous and stimulus-evoked neuronal, cholinergic, and hemodynamic activity in awake, head-fixed mice with a curved "crystal skull" window expressing the red calcium indicator jRGECO1a and the green acetylcholine sensor GRABACh3.0. Shielding of illumination light through the aluminum hemisphere enables concurrent recording of pupil diameter changes. Conclusions: Our widefield microscope design with a single camera can be used to acquire multiple aspects of brain physiology and is compatible with behavioral readouts of pupil diameter. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level–Dependent Functional Magnetic Resonance Imaging

Author

Desjardins, Michèle, Kılıç, Kıvılcım, Thunemann, Martin, Mateo, Celine, Holland, Dominic, Ferri, Christopher G.L., Cremonesi, Jonathan A., Li, Baoqiang, Cheng, Qun, Weldy, Kimberly L., Saisan, Payam A., Kleinfeld, David, Komiyama, Takaki, Liu, Thomas T., Bussell, Robert, Wong, Eric C., Scadeng, Miriam, Dunn, Andrew K., Boas, David A., Sakadžić, Sava, Mandeville, Joseph B., Buxton, Richard B., Dale, Anders M., and Devor, Anna

Published
2019
Full Text
View/download PDF

10. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives

Author

Amadio, Jordan, Bi, Guo-Qiang, Boshears, Paul Frederick, Carter, Adrian, Devor, Anna, Doya, Kenji, Garden, Hermann, Illes, Judy, Johnson, L. Syd M., Jorgenson, Lyric, Jun, Bang-Ook, Lee, Inyoung, Michie, Patricia, Miyakawa, Tsuyoshi, Nakazawa, Eisuke, Sakura, Osamu, Sarkissian, Hagop, Sullivan, Laura Specker, Uh, Stepheni, Winickoff, David, Wolpe, Paul Root, Wu, Kevin Chien-Chang, Yasamura, Akira, Zheng, Jialin C., Rommelfanger, Karen S., Jeong, Sung-Jin, Ema, Arisa, Fukushi, Tamami, Kasai, Kiyoto, Ramos, Khara M., Salles, Arleen, and Singh, Ilina

Published
2018
Full Text
View/download PDF

16. Understanding the nervous system: lessons from Frontiers in Neurophotonics.

Author

De Koninck, Yves, Alonso, Johanna, Bancelin, Stéphane, Béïque, Jean-Claude, Bélanger, Erik, Bouchard, Catherine, Canossa, Marco, Chaniot, Johan, Choquet, Daniel, Crochetière, Marie-Ève, Cui, Nanke, Danglot, Lydia, De Koninck, Paul, Devor, Anna, Ducros, Mathieu, Getz, Angela M., Haouat, Mohamed, Hernández, Iván Coto, Jowett, Nate, and Keramidis, Iason

Abstract

This document is a compilation of various scientific articles related to neurophotonics and neuroscience research. The articles cover a range of topics including the development of genetically encoded fluorescent indicators for imaging, synaptic function and plasticity, high-resolution microscopy techniques, optogenetics, and the use of advanced imaging technologies in studying the nervous system. The articles provide valuable insights into the understanding of the nervous system and offer potential applications for further research in the field. The document is a list of references to scientific articles related to neuroscience and neurophotonics. It includes articles on topics such as imaging techniques, synaptic plasticity, and dendritic computation. The document does not provide any biographical information about the authors. [Extracted from the article]

Published
2024
Full Text
View/download PDF

19. The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements

Author

Uhlirova, Hana, Kιlιç, Kιvιlcιm, Tian, Peifang, Sakadžić, Sava, Gagnon, Louis, Thunemann, Martin, Desjardins, Michèle, Saisan, Payam A., Nizar, Krystal, Yaseen, Mohammad A., Hagler, Donald J., Vandenberghe, Matthieu, Djurovic, Srdjan, Andreassen, Ole A., Silva, Gabriel A., Masliah, Eliezer, Kleinfeld, David, Vinogradov, Sergei, Buxton, Richard B., Einevoll, Gaute T., Boas, David A., Dale, Anders M., and Devor, Anna

Published
2016

22. Special Section Guest Editorial: Frontiers in Neurophotonics.

Author

De Koninck, Yves, De Koninck, Paul, Devor, Anna, and Lavoie-Cardinal, Flavie

Abstract

This document is a guest editorial from the journal Neurophotonics, introducing a special section on Frontiers in Neurophotonics. The special section is a collection of papers inspired by a symposium held in 2022 in Québec City, Canada. The papers cover a range of topics related to advanced optical approaches for studying brain functions, including super-resolution microscopy, in vivo imaging of brain activity, imaging of synaptic function, manipulation of synaptic activity, data analysis and computational modeling, and the development of neurophotonics tools for biological applications. The editorial also mentions a summary paper that reflects the collaborative spirit of the community. [Extracted from the article]

Published
2024
Full Text
View/download PDF

24. The Challenge of Connecting the Dots in the B.R.A.I.N.

Author

Devor, Anna, Bandettini, Peter A., Boas, David A., Bower, James M., Buxton, Richard B., Cohen, Lawrence B., Dale, Anders M., Einevoll, Gaute T., Fox, Peter T., Franceschini, Maria Angela, Friston, Karl J., Fujimoto, James G., Geyer, Mark A., Greenberg, Joel H., Halgren, Eric, Hämäläinen, Matti S., Helmchen, Fritjof, Hyman, Bradley T., Jasanoff, Alan, Jernigan, Terry L., Judd, Lewis L., Kim, Seong-Gi, Kleinfeld, David, Kopell, Nancy J., Kutas, Marta, Kwong, Kenneth K., Larkum, Matthew E., Lo, Eng H., Magistretti, Pierre J., Mandeville, Joseph B., Masliah, Eliezer, Mitra, Partha P., Mobley, William C., Moskowitz, Michael A., Nimmerjahn, Axel, Reynolds, John H., Rosen, Bruce R., Salzberg, Brian M., Schaffer, Chris B., Silva, Gabriel A., So, Peter T.C., Spitzer, Nicholas C., Tootell, Roger B., Van Essen, David C., Vanduffel, Wim, Vinogradov, Sergei A., Wald, Lawrence L., Wang, Lihong V., Weber, Bruno, and Yodh, Arjun G.

Published
2013
Full Text
View/download PDF

26. Never bored!

Author

Devor, Anna

Subjects
SMALL talk, OPTICAL engineering, CONSUMERS, SUPPLY & demand, SMILING
Abstract

The editorial "Never bored!" from Neurophotonics, written by Anna Devor, describes a brief encounter at a Trader Joe's checkout line where the author discusses her work as a professor studying neurophotonics. The author expresses enthusiasm for her work and the scientific community, highlighting the talent and potential for groundbreaking discoveries in the field. The editorial conveys a sense of inspiration and excitement for the future of neuroscience research. [Extracted from the article]

Published
2024
Full Text
View/download PDF

31. Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging

Author

Yuan, Shuai, Devor, Anna, Boas, David A., and Dunn, Anderew K.

Subjects
Laser speckle -- Research, Blood flow -- Research, Contrast echocardiography -- Research, Optics -- Research, Astronomy, Physics
Abstract

Laser speckle contrast imaging is becoming an established method for full-field imaging of cerebral blood flow dynamics in animal models. The sensitivity and noise in the measurement of blood flow changes depend on the camera exposure time. The relation among sensitivity, noise, and camera exposure time was investigated experimentally by imaging the speckle contrast changes in the brain after electrical forepaw stimulation in rats. The sensitivity to relative changes in speckle contrast was found to increase at longer exposure times and to reach a plateau for exposure times greater than approximately 2 ms. However, the speckle contrast noise also increases with exposure time and thus the contrast-to-noise ratio was found to peak at an exposure time of approximately 5 ms. Our results suggests that ~5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents. OCIS codes: 120.6150, 170.3880, 170.1650.

Published
2005

34. Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces.

Author

Lee, Sang Heon, Thunemann, Martin, Lee, Keundong, Cleary, Daniel R., Tonsfeldt, Karen J., Oh, Hongseok, Azzazy, Farid, Tchoe, Youngbin, Bourhis, Andrew M., Hossain, Lorraine, Ro, Yun Goo, Tanaka, Atsunori, Kılıç, Kıvılcım, Devor, Anna, and Dayeh, Shadi A.

Subjects
BRAIN-computer interfaces, EVOKED potentials (Electrophysiology), BRAIN mapping, MICROFABRICATION, ELECTROPHYSIOLOGY, WHISKERS
Abstract

The Utah array powers cutting‐edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in the last three decades. Here, advanced dual‐side lithographic microfabrication processes is exploited to demonstrate a 1024‐channel penetrating silicon microneedle array (SiMNA) that is scalable in its recording capabilities and cortical coverage and is suitable for clinical translation. The SiMNA is the first penetrating microneedle array with a flexible backing that affords compliancy to brain movements. In addition, the SiMNA is optically transparent permitting simultaneous optical and electrophysiological interrogation of neuronal activity. The SiMNA is used to demonstrate reliable recordings of spontaneous and evoked field potentials and of single unit activity in chronically implanted mice for up to 196 days in response to optogenetic and to whisker air‐puff stimuli. Significantly, the 1024‐channel SiMNA establishes detailed spatiotemporal mapping of broadband brain activity in rats. This novel scalable and biocompatible SiMNA with its multimodal capability and sensitivity to broadband brain activity will accelerate the progress in fundamental neurophysiological investigations and establishes a new milestone for penetrating and large area coverage microelectrode arrays for brain–machine interfaces. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

39. Microscale physiological events on the human cortical surface detected with PEDOT:PSS Electrodes

Author

Paulk, Angelique C., Yang, Jimmy C., Cleary, Daniel R., Soper, Daniel J., Lee, Sang Heon, Ganji, Mehran, Ro, Yun Goo, Oh, Hongseok, Hossain, Lorraine, Rogers, Nick, Kiliç, Kivilcim, Ryu, Sang Baek, Lee, Seung Woo, Hermiz, John, Gilja, Vikash, Lee, Jong Woo, Maus, Douglas, Devor, Anna, Fried, Shelley I., Jones, Pamela S., Nahed, Brian V., Ben-Haim, Sharona, Raslan, Ahmed M. T., Siler, Dominic A., Cahill, Daniel P., Williams, Ziv M., Cosgrove, G. Rees, Dayeh, Shadi A., and Cash, Sydney S.

Abstract

Summary Efforts to deepen our understanding of the nervous system depends on high resolution sampling of neuronal activity. We leveraged clinically necessary intracranial monitoring performed during surgical resections to record from the cortical surface (N=30) using high spatial resolution, low impedance PEDOT:PSS microelectrodes. We identified three classes of activity. The first included relatively fast repeated waveforms with kinetics similar to, but not perfectly matching, extracellular single unit activity. The other two discrete unitary events with slower waveforms had event frequencies which were selectively modulated by auditory stimuli, electrical stimuli, pharmacological manipulation, and cold saline application. Furthermore, different classes had small but significant causal co-occurrences. We speculate that these different events could reflect axonal action potentials, dendritic calcium spikes, backpropagating action potentials or pre and post-synaptic phenomena, opening the possibility that we can sample information beyond typical extracellular somatic action potentials via high-density, low impedance electrodes on the cortical surface.

Published
2019
Full Text
View/download PDF

40. Dependence of the Magnetic Resonance Signal on the Magnetic Susceptibility of Blood Studied with Models Based on Real Microvascular Networks

Author

Cheng, Xiaojun, Berman, Avery J.L., Polimeni, Jonathan R., Buxton, Richard B., Gagnon, Louis, Devor, Anna, Sakadžić, Sava, and Boas, David A.

Subjects
Cerebral Cortex, Mice, Inbred C57BL, Mice, Perfusion Imaging, Microvessels, Models, Cardiovascular, Animals, Contrast Media, Magnetic Resonance Imaging, Monte Carlo Method, Article
Abstract

PURPOSE: The primary goal of this study was to estimate the value of β, the exponent in the power law relating changes of the transverse relaxation rate and intra-extravascular local magnetic susceptibility differences as [Formula: see text]. The secondary objective was to evaluate any differences that might exist in the value of β obtained using a deoxyhemoglobin-weighted [Formula: see text] distribution versus a constant [Formula: see text] distribution assumed in earlier computations. The third objective was to estimate the value of β relevant for methods based on susceptibility contrast agents with a concentration of [Formula: see text] higher than that used for BOLD fMRI calculations. METHODS: Our recently developed model of real microvascular anatomical networks is utilized to extend the original simplified Monte-Carlo simulations to compute [Formula: see text] from first principles. RESULTS: Our results show that [Formula: see text] for most BOLD fMRI measurements of real vascular networks as opposed to earlier predictions of [Formula: see text] using uniform [Formula: see text] distributions. For perfusion or functional MRI methods based on contrast agents, which generate larger values for [Formula: see text] , [Formula: see text] for [Formula: see text] , while at 14 T [Formula: see text] can drop below 1 and the variation across subjects is large, which indicates that a lower concentration of contrast agent with a lower value of [Formula: see text] is desired for experiments at high [Formula: see text]. CONCLUSION: These results improve our understanding of the relationship between R(2)* and the underlying microvascular properties. The findings will help to infer the cerebral metabolic rate of oxygen (CMRO(2)) and cerebral blood volume (CBV) from BOLD and perfusion MRI respectively.

Published
2019

44. All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors.

Author

Puppo, Francesca, Sadegh, Sanaz, Trujillo, Cleber A., Thunemann, Martin, Campbell, Evan P., Vandenberghe, Matthieu, Shan, Xiwei, Akkouh, Ibrahim A., Miller, Evan W., Bloodgood, Brenda L., Silva, Gabriel A., Dale, Anders M., Einevoll, Gaute T., Djurovic, Srdjan, Andreassen, Ole A., Muotri, Alysson R., and Devor, Anna

Subjects
INDUCED pluripotent stem cells, VOLTAGE, ELECTROPHYSIOLOGY, NEURONS
Abstract

Voltage imaging and "all-optical electrophysiology" in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing unique genetic backgrounds of individual patients. While prior all-optical electrophysiology studies relied on genetically encoded voltage indicators, here, we demonstrate an alternative protocol using a synthetic voltage sensor and genetically encoded optogenetic actuator that generate robust and reproducible results. We demonstrate the functionality of this method by measuring spontaneous and evoked activity in three independent hiPSC-derived neuronal cell lines with distinct genetic backgrounds. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

45. Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice.

Author

Kılıç, Kıvılcım, Desjardins, Michèle, Tang, Jianbo, Thunemann, Martin, Sunil, Smrithi, Erdener, Şefik Evren, Postnov, Dmitry D., Boas, David A., and Devor, Anna

Subjects
MICE, BRAIN imaging, OPERATIVE surgery
Abstract

Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail a suite of surgical techniques for installation of different cranial windows targeted for specific imaging technologies and their combination. Following these techniques and practices will yield higher experimental success and reproducibility of results. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

49. Impact of Brain Surface Boundary Conditions on Electrophysiology and Implications for Electrocorticography.

Author

Rogers, Nicholas, Thunemann, Martin, Devor, Anna, and Gilja, Vikash

Subjects
ELECTROENCEPHALOGRAPHY, ELECTROPHYSIOLOGY, INSULATING materials, ELECTRIC potential, BRAIN, ELECTRICAL impedance tomography
Abstract

Volume conduction of electrical potentials in the brain is highly influenced by the material properties and geometry of the tissue and recording devices implanted into the tissue. These effects are very large in EEG due to the volume conduction through the skull and scalp but are often neglected in intracranial electrophysiology. When considering penetrating electrodes deep in the brain, the assumption of an infinite and homogenous medium can be used when the sources are far enough from the brain surface and the electrodes to minimize the boundary effect. When the electrodes are recording from the brain's surface the effect of the boundary cannot be neglected, and the large surface area and commonly used insulating materials in surface electrode arrays may further increase the effect by altering the nature of the boundary in the immediate vicinity of the electrodes. This gives the experimenter some control over the spatial profiles of the potentials by appropriate design of the electrode arrays. We construct a simple three-layer model to describe the effect of material properties and geometry above the brain surface on the electric potentials and conduct empirical experiments to validate this model. A laminar electrode array is used to measure the effect of insulating and relatively conducting layers above the cortical surface by recording evoked potentials alternating between a dried surface and saline covering layer, respectively. Empirically, we find that an insulating boundary amplifies the potentials relative to conductive saline by about a factor of 4, and that the effect is not constrained to potentials that originate near the surface. The model is applied to predict the influence of array design and implantation procedure on the recording amplitude and spatial selectivity of the surface electrode arrays. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

50. Making the MOSTest of Imaging Genetics

Author

van der Meer, Dennis, Frei, Oleksandr, Kaufmann, Tobias, Shadrin, Alexey, Devor, Anna, Smeland, Olav, Thompson, Wesley, Fan, Chun, Holland, Dominic, Westlye, Lars, Andreassen, Ole, and Dale, Anders M.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results