Search

Your search keyword '"Deseke, Malte"' showing total 8 results
Start Over Author "Deseke, Malte" Language english
8 results on '"Deseke, Malte"'

8. A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR.

Author

Deseke M, Rampoldi F, Sandrock I, Borst E, Böning H, Ssebyatika GL, Jürgens C, Plückebaum N, Beck M, Hassan A, Tan L, Demera A, Janssen A, Steinberger P, Koenecke C, Viejo-Borbolla A, Messerle M, Krey T, and Prinz I

Subjects
Clone Cells, HLA-DR Antigens, Humans, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocyte Subsets, Cytomegalovirus Infections, Intraepithelial Lymphocytes
Abstract

The innate and adaptive roles of γδ T cells and their clonal γδ T cell receptors (TCRs) in immune responses are still unclear. Recent studies of γδ TCR repertoire dynamics showed massive expansion of individual Vδ1+ γδ T cell clones during viral infection. To judge whether such expansion is random or actually represents TCR-dependent adaptive immune responses, information about their cognate TCR ligands is required. Here, we used CRISPR/Cas9-mediated screening to identify HLA-DRA, RFXAP, RFX5, and CIITA as required for target cell recognition of a CMV-induced Vγ3Vδ1+ TCR, and further characterization revealed a direct interaction of this Vδ1+ TCR with the MHC II complex HLA-DR. Since MHC II is strongly upregulated by interferon-γ, these results suggest an inflammation-induced MHC-dependent immune response of γδ T cells., (© 2022 Deseke et al.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results