16,813 results on '"Department of Health Policy and Management"'
Search Results
2. Deaths of despair: a scoping review on the social determinants of drug overdose, alcohol-related liver disease and suicide
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Beseran, Elisabet, Pericàs, Juan M., Cash-Gibson, Lucinda, Ventura-Cots, Meritxell, Porter, Keshia M. Pollack, Benach, Joan, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Beseran E] Research Group on Health Inequalities, Environment, and Employment Conditions, Pompeu Fabra University, Barcelona, Spain. [Pericàs JM] Research Group on Health Inequalities, Environment, and Employment Conditions, Pompeu Fabra University, Barcelona, Spain. Unitat Hepàtica, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERehd, Barcelona, Spain. Johns Hopkins University—Pompeu Fabra University Public Policy Center (UPF-BSM), Barcelona, Spain. [Cash-Gibson L] Research Group on Health Inequalities, Environment, and Employment Conditions, Pompeu Fabra University, Barcelona, Spain. Johns Hopkins University—Pompeu Fabra University Public Policy Center (UPF-BSM), Barcelona, Spain. UPF Barcelona School of Management, Pompeu Fabra University, Barcelona, Spain. [Ventura-Cots M] Unitat Hepàtica, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERehd, Barcelona, Spain. [Porter KMP] Johns Hopkins University—Pompeu Fabra University Public Policy Center (UPF-BSM), Barcelona, Spain. Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada. Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. [Benach J] Research Group on Health Inequalities, Environment, and Employment Conditions, Pompeu Fabra University, Barcelona, Spain. Johns Hopkins University—Pompeu Fabra University Public Policy Center (UPF-BSM), Barcelona, Spain. Ecological Humanities Research Group (GHECO), Universidad Autónoma de Madrid, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
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trastornos inducidos químicamente::trastornos relacionados con sustancias::trastornos relacionados con el alcohol::trastornos inducidos por alcohol::enfermedades hepáticas alcohólicas [ENFERMEDADES] ,Adolescent ,Características de la Población::demografía::estado de salud::determinantes sociales de la salud [ATENCIÓN DE SALUD] ,Health, Toxicology and Mutagenesis ,death of despair ,Fetge - Malalties ,Social determinants of health ,Drogoaddicció ,Humans ,trastornos inducidos químicamente::trastornos relacionados con sustancias::sobredosis de sustancias [ENFERMEDADES] ,Suïcidi ,Death of despair ,Health inequalities ,Population Characteristics::Demography::Health Status::Social Determinants of Health [HEALTH CARE] ,conducta y mecanismos de la conducta::conducta::síntomas conductuales::conducta autolesiva::suicidio [PSIQUIATRÍA Y PSICOLOGÍA] ,Public health ,Liver Diseases ,public health ,Public Health, Environmental and Occupational Health ,health inequalities ,Chemically-Induced Disorders::Substance-Related Disorders::Drug Overdose [DISEASES] ,United States ,Suicide ,Unemployment ,social determinants of health ,Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Self-Injurious Behavior::Suicide [PSYCHIATRY AND PSYCHOLOGY] ,Drug Overdose ,Chemically-Induced Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcohol-Induced Disorders::Liver Diseases, Alcoholic [DISEASES] - Abstract
Death of despair; Health inequalities; Public health Muerte de desesperación; Desigualdades en salud; Salud pública Mort de desesperació; Desigualtats en salut; Salut pública Background: There is a lack of consensus on the social determinants of Deaths of Despair (DoD), i.e., an increase in mortality attributed to drug overdose, alcohol-related liver disease, and suicide in the United States (USA) during recent years. The objective of this study was to review the scientific literature on DoD with the purpose of identifying relevant social determinants and inequalities related to these mortality trends. Methods: Scoping review focusing on the period 2015–2022 based on PubMed search. Articles were selected according to the following inclusion criteria: published between 1 January 2000 and 31 October 2021; including empirical data; analyzed DoD including the three causes defined by Case and Deaton; analyzed at least one social determinant; written in English; and studied DoD in the USA context only. Studies were excluded if they only analyzed adolescent populations. We synthesized our findings in a narrative report specifically addressing DoD by economic conditions, occupational hazards, educational level, geographical setting, and race/ethnicity. Results: Seventeen studies were included. Overall, findings identify a progressive increase in deaths attributable to suicide, drug overdose, and alcohol-related liver disease in the USA in the last two decades. The literature concerning DoD and social determinants is relatively scarce and some determinants have been barely studied. However different, however, large inequalities have been identified in the manner in which the causes of death embedded in the concept of DoD affect different subpopulations, particularly African American, and Hispanic populations, but blue collar-whites are also significantly impacted. Low socioeconomic position and education levels and working in jobs with high insecurity, unemployment, and living in rural areas were identified as the most relevant social determinants of DoD. Conclusions: There is a need for further research on the structural and intermediate social determinants of DoD and social mechanisms. Intersectional and systemic approaches are needed to better understand and tackle DoD and related inequalities.
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- 2022
3. Understanding environmental risk: the role of the laboratory in epidemiology, evaluation, and policy setting
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Burke, T [Johns Hopkins University, School of Hygiene and Public Health, Department of Health Policy and Management, Baltimore, MD (United States)]
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- 1992
4. Changing Structure and Sustainable Development for China’s Hog Sector
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Feng Chu, Xiaoheng Zhang, Yingheng Zhou, Xu Tian, Jinyang Yang, Xianhui Geng, Xiaohua Yu, College of Economics and Management (College of Economics and Management), Nanjing Agricultural University (NAU), Informatique, Biologie Intégrative et Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE), Management Engineering Research Center, Xihua University, Courant Research Centre Poverty, Inequity and Growth, Georg-August-University = Georg-August-Universität Göttingen, Department of Health Policy and Management, Yale University [New Haven], Nanjing Agricultural University, and Georg-August-University [Göttingen]
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China ,Natural resource economics ,Geography, Planning and Development ,TJ807-830 ,Economic shortage ,Management, Monitoring, Policy and Law ,TD194-195 ,Hog production ,Renewable energy sources ,Market economy ,0502 economics and business ,Production (economics) ,GE1-350 ,050207 economics ,Productivity ,2. Zero hunger ,Sustainable development ,Environmental effects of industries and plants ,Renewable Energy, Sustainability and the Environment ,Production cost ,05 social sciences ,Metafrontier ,[INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO] ,Environmental sciences ,13. Climate action ,productivity ,metafrontier ,production cost ,hog production ,050202 agricultural economics & policy ,Business ,Allocative efficiency ,Inefficiency - Abstract
International audience; Supply shortages and competitive disadvantages are the main problems faced by China's hog sector. The non-essential import of pork products, triggered by competitive disadvantages, poses great challenges to hog farms. Structural changes are an important policy concern in China and elsewhere. Previous literature has ignored whether the ongoing structural changes from backyard to large farms can contribute to sustainable development. This study adopts the micro-level data of hog farms collected from Jiangsu Province, and uses a two-step metafrontier model and a primal system approach. The empirical results reveal that the ongoing structural changes are capable of boosting the growth in output in China's hog sector, since the stronger increase in comparable technical efficiency compensates for the inappropriate technology. Furthermore, the ongoing structural changes are also beneficial in the reduction of production costs and in improving competitiveness in China's hog sector. The decline in technical and allocative inefficiency costs, particularly for technical inefficiency costs, contributes to the cost advantage with the increasing farm size.
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- 2017
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5. Ethics in Research with Vulnerable Populations and Emerging Countries: The Golden Rice Case
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Duguet, Anne-Marie, Altavilla, Annagrazia, Wu, Tao, Man, Hongjie, Harris, Dean M., Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Espace éthique méditerranéen, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Law School, Shandong University, Department of Health Policy and Management, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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ComputingMilieux_MISCELLANEOUS ,[SDV.ETH]Life Sciences [q-bio]/Ethics - Abstract
International audience
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- 2013
6. Scaling up the 2010 World Health Organization HIV Treatment Guidelines in resource-limited settings: a model-based analysis
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Rochelle P Walensky, Robin Wood, Andrea L Ciaranello, A David Paltiel, Sarah B Lorenzana, Xavier Anglaret, Adam W Stoler, Kenneth A Freedberg, CEPAC-International Investigators, Department of Infectious Disease [Boston], Massachusetts General Hospital [Boston], Division of General Medicine, Center for AIDS Research [Cambridge], Harvard University [Cambridge], Division of Infectious Disease, Brigham and Women's Hospital [Boston], Desmond Tutu HIV Centre, University of Cape Town-Institute of Infectious Disease and Molecular Medicine, Department of Epidemiology, Yale School of Medicine [New Haven, Connecticut] (YSM), Epidémiologie et Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, Department of Health Policy and Management, Harvard School of Public Health, This work was supported by the National Institute of Allergy and Infectious Diseases (R01 AI058736, K24 AI062476, P30 AI060354, K01 AI078754), National Institute on Drug Abuse (R01 DA015612), and the Doris Duke Charitable Foundation (Clinical Scientist Development Award)., the CEPAC-International Investigators, Mouillet, Evelyne, and Faculty of Health Sciences
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Male ,Pediatrics ,Life expectancy ,Cost-Benefit Analysis ,lcsh:Medicine ,HIV Infections ,030204 cardiovascular system & hematology ,MESH: World Health Organization ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Medicine ,Opportunistic infections ,030212 general & internal medicine ,Hiv treatment ,MESH: Anti-HIV Agents ,MESH: Models, Theoretical ,Stavudine ,MESH: Guidelines as Topic ,General Medicine ,Cost-effectiveness analysis ,MESH: HIV Infections ,Public Health and Epidemiology/Global Health ,Infectious Diseases/HIV Infection and AIDS ,Antiretroviral therapy ,3. Good health ,AIDS ,MESH: Young Adult ,Cohort ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Female ,medicine.drug ,Research Article ,Adult ,medicine.medical_specialty ,Anti-HIV Agents ,Guidelines as Topic ,Public Health and Epidemiology/Health Policy ,World Health Organization ,World health ,03 medical and health sciences ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Treatment guidelines ,Humans ,MESH: Acquired Immunodeficiency Syndrome ,Acquired Immunodeficiency Syndrome ,MESH: Humans ,business.industry ,lcsh:R ,HIV ,MESH: Adult ,Guideline ,Models, Theoretical ,medicine.disease ,Virology ,MESH: Male ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Female ,MESH: Cost-Benefit Analysis - Abstract
Rochelle Walensky and colleagues use a model-based analysis to examine which of the 2010 WHO antiretroviral therapy guidelines should be implemented first in resource-limited settings by ranking them according to survival, cost-effectiveness, and equity., Background The new 2010 World Health Organization (WHO) HIV treatment guidelines recommend earlier antiretroviral therapy (ART) initiation (CD4, Editors' Summary Background Since 1981, acquired immunodeficiency syndrome (AIDS) has killed more than 25 million people, and about 33 million people (30 million of them in low- and middle-income countries) are now infected with the human immunodeficiency virus (HIV), which causes AIDS. HIV destroys immune system cells (including CD4 cells, a type of lymphocyte), leaving infected individuals susceptible to other infections (so-called opportunistic infections). Early in the AIDS epidemic, most people with HIV died within 10 years of infection. Then, in 1996, highly active antiretroviral therapy (ART)—a combination of several powerful antiretroviral drugs—was developed. Now, in resource-rich countries, clinicians care for people with HIV by prescribing ART regimens tailored to each individual's needs. They also regularly measure the amount of virus in their patients' blood, test for antiretroviral-resistant viruses, and monitor the health of their patients' immune systems through regular CD4 cell counts. As a result, the life expectancy of patients with HIV in developed countries has dramatically improved. Why Was This Study Done? Initially, resource-limited countries could not afford to provide ART for their populations, and the life expectancy of HIV-positive people remained low. Now, through the concerted efforts of governments, the World Health Organization (WHO), and other international agencies, more than a third of the people in low- and middle-income countries who need ART are receiving it. However, many without access are still in need of ART, and ART programs in developing countries follow a public-health approach rather than an individualized approach. That is, drug regimens, clinical decision-making, and disease monitoring are all standardized and follow recommendations in the 2006 WHO ART guidelines. This year (2010), these guidelines were revised. The guidelines now recommend the following: earlier ART initiation—when the CD4 count falls below 350/µl of blood, instead of below 200/µl as in the 2006 guidelines; the provision of sequential ART regimens instead of a single regimen; and the replacement of the antiretroviral drug stavudine with tenofovir, a less toxic but more expensive drug, in first-line ART regimens. However, many resource-limited countries are still struggling to implement the 2006 guidelines, so which of these new recommendations should be prioritized? Here, the researchers use a mathematical model to address this question. What Did the Researchers Do and Find? The Cost Effectiveness of AIDS Complications (CEPAC)–International model simulates the natural history and treatment of HIV disease. The researchers entered South African clinical and cost data for HIV treatment into this model and then used it to project survival and costs in a hypothetical group of South African HIV-positive patients under alternative guideline prioritization scenarios. The reference strategy for the simulations (denoted as “stavudine/WHO/one-line”) assumed that patients (with a mean CD4 count of 375/µl) began a single stavudine-based ART regimen when they developed WHO stage III/IV HIV disease (i.e., when patients develop multiple opportunistic infections such as tuberculosis and pneumonia). When the new guideline recommendations were considered separately, ART initiation at CD4
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- 2010
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7. Lost but Not Forgotten - The Economics of Improving Patient Retention in AIDS Treatment Programs
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Elena Losina, Hapsatou Touré, Lauren M Uhler, Xavier Anglaret, A David Paltiel, Eric Balestre, Rochelle P Walensky, Eugène Messou, Milton C Weinstein, François Dabis, Kenneth A Freedberg, ART-LINC Collaboration of International Epidemiological Databases to Evaluate AIDS (IeDEA), CEPAC International investigators, Division of General Medicine, Massachusetts General Hospital [Boston], Department of Orthopedic Surgery, Brigham and Women's Hospital [Boston], Department of Biostatistics, Boston University [Boston] (BU), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Prise en charge, de Recherche et de Formation (CePReF), ACONDA, Yale University [New Haven], Department of Infectious Disease [Boston], Center for AIDS Research [Cambridge], Harvard University [Cambridge], Division of Infectious Disease, Department of Medicine, Harvard Medical School [Boston] (HMS), Department of Health Policy and Management, Harvard School of Public Health, Department of Genetics [Boston], Supported by the US National Institute of Allergy and Infectious Diseases (R01 AI058736, K24 AI062476, P30 AI 060354 Harvard University Center for AIDS Research, and 5U01AI069919 ART-LINC of IeDEA), the French Agence Nationale de Recherches sur le SIDA et les hépatites (ANRS 12 138 ART-LINC LTFU), the Office of AIDS Research (National Institutes of Health), the National Cancer Institute, the Eunice Kennedy Shriver National Institute of Child Health & Human Development, and the Doris Duke Charitable Foundation, Clinical Scientist Development Award (to RPW)., the ART-LINC Collaboration of International Epidemiological Databases to Evaluate AIDS, the CEPAC International investigators, Mouillet, Evelyne, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2
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Gerontology ,Cost effectiveness ,Cost-Benefit Analysis ,lcsh:Medicine ,Public Health and Epidemiology/Infectious Diseases ,HIV Infections ,MESH: Antiretroviral Therapy, Highly Active ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Antiretroviral Therapy, Highly Active ,Global health ,030212 general & internal medicine ,Hiv treatment ,MESH: Anti-HIV Agents ,Sida ,MESH: Developing Countries ,health care economics and organizations ,MESH: Treatment Outcome ,biology ,1. No poverty ,General Medicine ,MESH: Follow-Up Studies ,MESH: HIV Infections ,Public Health and Epidemiology/Global Health ,Infectious Diseases/HIV Infection and AIDS ,Human development (humanity) ,3. Good health ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Life Expectancy ,Research Article ,medicine.medical_specialty ,MESH: Cote d'Ivoire ,030231 tropical medicine ,MESH: Health Care Costs ,Cote d ivoire ,Child health ,03 medical and health sciences ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,MESH: Humans ,business.industry ,lcsh:R ,medicine.disease ,biology.organism_classification ,Cote d'Ivoire ,Socioeconomic Factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Family medicine ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Cost-Benefit Analysis ,Follow-Up Studies - Abstract
Based on data from West Africa, Elena Losina and colleagues predict that interventions to reduce dropout rates from HIV treatment programs (such as eliminating copayments) will be cost-effective., Background Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa. Methods and Findings We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) International model to project the clinical benefits and cost-effectiveness of LTFU-prevention programs from a payer perspective. These programs include components such as eliminating ART co-payments, eliminating charges to patients for opportunistic infection-related drugs, improving personnel training, and providing meals and reimbursing for transportation for participants. The efficacies and costs of these interventions were extensively varied in sensitivity analyses. We used World Health Organization criteria of, Editors' Summary Background Acquired immunodeficiency syndrome (AIDS) has killed more than 25 million people since the first reported case in 1981. Currently, about 33 million people are infected with the human immunodeficiency virus (HIV), which causes AIDS. Two-thirds of people infected with HIV live in sub-Saharan Africa. HIV infects and destroys immune system cells, thereby weakening the immune system and rendering infected individuals susceptible to infection. There is no cure for HIV/AIDS. Combination antiretroviral therapy (ART), a mixture of antiretroviral drugs that suppress the replication of the virus in the body, is used to treat and prevent HIV infection. ART is expensive but major international efforts by governments, international organizations, and funding bodies have increased ART availability. According to World Health Organization (WHO) estimates, at least 9.7 million people in low- and middle-income countries need ART and as of 2007, 3 million of those people had reliable access to the drugs. Why Was This Study Done? Although ART is an effective treatment for HIV, a large number of individuals who initiate ART do not receive long-term follow-up care. These patients are generally sicker and have a worse long-term outcome than those who receive follow-up care. Loss to follow up (LTFU) is a significant problem that can undermine the benefits of expanding ART availability. Strategies to improve follow up concentrate on bringing lost patients back into the health care system, but such patients often die before they can be contacted. Prevention of LTFU might be a better strategy to improve HIV care after ART initiation, but there is little information available on which specific interventions might best accomplish this goal. What Did the Researchers Do and Find? Given the lack of reported data on the actual costs and effectiveness of LTFU prevention, the researchers used a model to estimate the clinical impact and cost-effectiveness of several possible strategies to prevent LTFU in HIV-infected persons receiving ART in Côte d'Ivoire, West Africa. The researchers used the previously developed Cost-Effectiveness of Preventing AIDS Complications (CEPAC) computer simulation model and combined it with data from a program of ART delivery in Abidjan, Côte d'Ivoire. They then projected the clinical benefits and the cost required to attain a given level of benefit (cost-effectiveness ratio) of different LTFU-prevention strategies from the perspective of the payer (the organization that pays all the medical costs to provide care). Several interventions were considered, including reducing costs to patients (eliminating patient co-payments and paying for transportation) and increasing services to patients at their visits (improving staff training in HIV care, and providing meals at clinic times). LTFU was predicted to cause a 54.3%–58.3% reduction in the estimated life expectancy beyond age 37; patients continuing HIV care were predicted to live a further 144.7 months whie those lost to follow up by 1 year after ART initiation were predicted to live only for a further 73.9–80.7 months. LTFU-prevention strategies in the Côte d'Ivoire were deemed to be cost-effective if they cost less than $2,823 (which is 3× gross domestic product per capita) per year of life saved. The efficacy and cost of the different LTFU-prevention strategies varied in the analyses; stopping ART co-payment alone would be cost-effective at a cost of $22/person/year if it reduced LTFU rates by 12%, while including all the LTFU-prevention strategies described would be cost-effective at $77/person/year if they reduced LTFU-rates by 41%. What Do These Findings Mean? The findings suggest that moderately effective strategies for preventing LTFU in resource-limited settings would improve survival, provide good value for money, and should be used to improve HIV treatment programs. Although modeling is valuable to explore the costs and effectiveness of LTFU-prevention strategies it cannot replace the need for more reported data to shed light on problems leading to LTFU and the prevention strategies required to combat it. Also, Côte d'Ivoire might not be representative of all West African countries or resource-limited settings. A similar analysis using data from other ART programs in different countries would be useful to provide better understanding of the impact of LTFU in HIV treatment programs. Finally, the research highlights the cost of second-line ART (a new antiretroviral drug combination for patients in whom first-line treatment fails) as a crucial issue. It is estimated that 5% of all people receiving ART in low- and middle-income countries receive second-line ART and these numbers are expected to increase. Second-line ART had major effects on cost-effectiveness, and a reduction in the cost of this treatment is critical in order to guarantee continued access to HIV treatment. Additional Information Please access these Web sites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1000173. This study is further discussed in a PLoS Medicine Perspective by Gregory Bisson and Jeffrey Stringer WHO provides information on disease prevention, treatment, and HIV/AIDS programs and projects The UN Millennium Development Goals project site contains information on worldwide efforts to halt the spread of HIV/AIDS aidsmap, a nonprofit, nongovernmental organization, provides information on HIV and supporting those living with HIV
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- 2009
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8. The challenge of admitting the very elderly to intensive care
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Bertrand Guidet, Yên-Lan Nguyen, Ariane Boumendil, Derek C. Angus, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Department of Health Policy and Management, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), BMC, Ed., Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)
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medicine.medical_specialty ,Population ageing ,[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,health care facilities, manpower, and services ,Population ,Review ,Critical Care and Intensive Care Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Intensive care ,Acute care ,Anesthesiology ,Epidemiology ,Health care ,medicine ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,030212 general & internal medicine ,education ,education.field_of_study ,business.industry ,030208 emergency & critical care medicine ,Intensive care unit ,3. Good health ,Emergency medicine ,business - Abstract
International audience; ABSTRACT: The aging of the population has increased the demand for healthcare resources. The number of patients aged 80 years and older admitted to the intensive care unit (ICU) increased during the past decade, as has the intensity of care for such patients. Yet, many physicians remain reluctant to admit the oldest, arguing a "squandering" of societal resources, that ICU care could be deleterious, or that ICU care may not actually be what the patient or family wants in this instance. Other ICU physicians are strong advocates for admission of a selected elderly population. These discrepant opinions may partly be explained by the current lack of validated criteria to select accurately the patients (of any age) who will benefit most from ICU hospitalization. This review describes the epidemiology of the elderly aged 80 years and older admitted in the ICU, their long-term outcomes, and to discuss some of the solutions to cope with the burden of an aging population receiving acute care hospitalization.
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- 2011
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9. Boceprevir for previously untreated patients with chronic hepatitis C Genotype 1 infection: a US-based cost-effectiveness modeling study
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Jean-Pierre Bronowicki, Antoine C. El Khoury, Clifford A. Brass, Fred Poordad, S. Ferrante, Elamin H. Elbasha, Jagpreet Chhatwal, Merck Sharp & Dohme Corp. (MSD), Whitehouse Station, Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Department of Industrial Engineering, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Novartis, Pharmaceuticals Corporation, Hepatology and Liver Transplantation, Cedars-Sinai Medical Center, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), This study was sponsored by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, NJ., and BMC, Ed.
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Male ,Cost effectiveness ,Cost-Benefit Analysis ,Hepacivirus ,medicine.disease_cause ,Hepatitis c virus ,Gastroenterology ,law.invention ,Polyethylene Glycols ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Boceprevir ,Hepatitis C ,Middle Aged ,Markov Chains ,Recombinant Proteins ,3. Good health ,Models, Economic ,Infectious Diseases ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030211 gastroenterology & hepatology ,Drug Therapy, Combination ,Female ,Quality-Adjusted Life Years ,Research Article ,Adult ,medicine.medical_specialty ,Proline ,Hepatitis C virus ,Alpha interferon ,Interferon alpha-2 ,Antiviral Agents ,03 medical and health sciences ,Double-Blind Method ,Internal medicine ,Ribavirin ,medicine ,Humans ,business.industry ,Interferon-alpha ,Hepatitis C, Chronic ,medicine.disease ,Economic evaluation ,Quality-adjusted life year ,chemistry ,Immunology ,Cost-effectiveness ,business - Abstract
International audience; BACKGROUND: SPRINT-2 demonstrated that boceprevir (BOC), an oral hepatitis C virus (HCV)- nonstructural 3 (NS3) protease inhibitor, added to peginterferon alfa-2b (P) and ribavirin (R) significantly increased sustained virologic response rates over PR alone in previously untreated adult patients with chronic HCV genotype 1. We estimated the long-term impact of triple therapy vs. dual therapy on the clinical burden of HCV and performed a cost-effectiveness evaluation. METHODS: A Markov model was used to estimate the incidence of liver complications, discounted costs (2010 US$), quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) of three treatment strategies for treatment-naive patients with chronic HCV genotype 1. The model simulates the treatment regimens studied in SPRINT-2 in which PR was administered for 4 weeks followed by: 1) placebo plus PR for 44 weeks (PR48); 2) BOC plus PR using response guided therapy (BOC/RGT); and 3) BOC plus PR for 44 weeks (BOC/PR48) and makes projections within and beyond the trial. HCV-related state-transition probabilities, costs, and utilities were obtained from previously published studies. All costs and QALYs were discounted at 3%. RESULTS: The model projected approximately 38% and 43% relative reductions in the lifetime incidence of liver complications in the BOC/RGT and BOC/PR48 regimens compared with PR48; respectively. Treatment with BOC/RGT is associated with an incremental cost of $10,348 and an increase of 0.62 QALYs compared to treatment with PR48. Treatment with BOC/PR48 is associated with an incremental cost of $35,727 and an increase of 0.65 QALYs compared to treatment with PR48. The ICERs were $16,792/QALY and $55,162/QALY for the boceprevir-based treatment groups compared with PR48, respectively. The ICER for BOC/PR48 compared with BOC/RGT was $807,804. CONCLUSION: The boceprevir-based regimens used in the SPRINT-2 trial were projected to substantially reduce the lifetime incidence of liver complications and increase the QALYs in treatment-naive patients with hepatitis C genotype 1. It was also demonstrated that boceprevir-based regimens offer patients the possibility of experiencing great clinical benefit with a shorter duration of therapy. Both boceprevir-based treatment strategies were projected to be cost-effective at a reasonable threshold in the US when compared to treatment with PR48.
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10. Receipt of respiratory vaccines among patients with heart failure in a multicenter health system registry.
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Dermenchyan A, Choi KR, Bokhoor PR, Cho DJ, Delavin NLA, Chima-Melton C, Han MA, and Fonarow GC
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- Humans, Male, Female, Aged, Middle Aged, Vaccination statistics & numerical data, Aged, 80 and over, Influenza, Human prevention & control, California epidemiology, Adult, Respiratory Tract Infections prevention & control, Heart Failure, Influenza Vaccines administration & dosage, Influenza Vaccines immunology, COVID-19 Vaccines administration & dosage, Pneumococcal Vaccines administration & dosage, Pneumococcal Vaccines immunology, COVID-19 prevention & control, Registries
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Background: Heart failure affects people of all ages and is a leading cause of death for both men and women in most racial and ethnic groups in the United States. Infections are common causes of hospitalizations in heart failure, with respiratory infections as the most frequent diagnosis. Vaccinations provide significant protection against preventable respiratory infections. Despite being an easily accessible intervention, prior studies suggest vaccines are underused in patients with heart failure., Methods: An observational study of 5089 adults with heart failure was conducted using data from an integrated, multicenter, academic health system in Southern California from 2019 to 2022. Logistic regression models were used to determine the rates of influenza, pneumococcal, and COVID-19 vaccination among a population of patients with heart failure (heart failure preserved ejection fraction [HFpEF], heart failure mildly reduced ejection fraction [HFmrEF], and heart failure reduced ejection fraction [HFrEF], and identify whether heart failure phenotype is associated with vaccination status., Results: Vaccination rates varied between influenza, pneumococcal, and COVID-19 vaccines. Of the three respiratory vaccines, 58.0 % of patients had received an influenza vaccine, 76.2 % had received a pneumococcal vaccine, and 83.3 % had received a COVID-19 vaccine. There were no sex-based differences by vaccination status. Differences were seen within age, race/ethnicity, insurance type, whether the patient was a member of an Accountable Care Organization (ACO), primary language, Social Vulnerability Index (SVI) score, clinician type, and number of comorbidities. Patients with HFpEF and HFmrEF had higher vaccination rates than HFrEF. In adjusted models, patients with HFrEF had lower odds of being vaccinated for influenza (aOR = 0.75, 95 % CI = 0.66-0.86), pneumococcal (aOR = 0.65, 95 % CI = 0.55-0.75), and COVID (aOR = 0.74, 95 % CI = 0.62-0.89) compared to patients with HFpEF., Conclusions: Patients with HFrEF had the lowest levels of respiratory vaccination compared to other specified heart failure categories. Interventions are needed to increase vaccination education and offerings, especially to patients with HFrEF., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Abbott that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Amgen Inc that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with AstraZeneca that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Bayer Corporation that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Boehringer Ingelheim Ltd that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Cytokinetics Inc that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Eli Lilly that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Johnson & Johnson Vision that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Medtronic that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Merck & Co Inc that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Novartis Pharmaceuticals Corporation that includes: consulting or advisory. Gregg C. Fonarow, MD, FACC, FAHA, FHSA reports a relationship with Pfizer Inc that includes: consulting or advisory. Chidinma Chima-Melton, MD, MBA, FCCP, CPHQ reports a relationship with AstraZeneca that includes: consulting or advisory. Chidinma Chima-Melton, MD, MBA, FCCP, CPHQ reports a relationship with Boehringer Ingelheim Corp USA that includes: consulting or advisory. Chidinma Chima-Melton, MD, MBA, FCCP, CPHQ reports a relationship with Gilead Sciences Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Ltd.)
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- 2025
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11. Gaps in psychiatric care before and after the COVID-19 pandemic among patients with depression using electronic health records.
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Ettman CK, Brantner CL, Goicoechea EB, Dohlman P, Ringlein GV, Straub J, Sthapit S, Mojtabai R, Spivak S, Albert M, Goes FS, Stuart EA, and Zandi PP
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- Humans, Male, Female, Middle Aged, Adult, Aged, Healthcare Disparities statistics & numerical data, SARS-CoV-2, Young Adult, COVID-19 epidemiology, COVID-19 psychology, Electronic Health Records statistics & numerical data, Mental Health Services statistics & numerical data, Depression epidemiology
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The COVID-19 pandemic caused disruption to health services. It is unclear if there were inequalities in the continuity of mental health care in the years around the COVID-19 pandemic. We used electronic health records (EHR) to detect mental health care gaps of more than six months in psychiatric appointments across demographic and socioeconomic characteristics among patients with depression. The analysis included patients with depression who were seen at one of two mental health clinics every year of 2018, 2019, 2021, and 2022 (n = 783 patients). First, we found that the odds of mental health care gaps significantly decreased in the post-pandemic period (2021-2022) relative to the pre-pandemic period (2018-2019). Second, in the pre-pandemic period, patients who lived in areas in the highest tertile of deprivation had greater odds of gaps in mental health care relative to those in the lowest tertile (aOR: 2.18 [95 % CI: 1.02, 4.68]). Males had higher odds of gaps in care than females in the post-pandemic period (aOR: 2.22 [1.13, 4.37]) and the pooled pre- and post-pandemic study period (aOR: 1.58 [1.04, 2.40]). Third, interactions between patient characteristics and time were not significant, suggesting that the change in the odds of gaps of mental health care before relative to after the COVID-19 pandemic did not differ significantly based on patient characteristics. Overall, gaps in care decreased in the post-pandemic period relative to the pre-pandemic period among almost all patient groups., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Dr. Mojtabai reports having received royalties and consulting fees from UpToDate, Medscape, and MindMed and providing expert consultation regarding social media litigation on behalf of the plaintiffs. The other authors report no financial relationships with commercial interests., (Copyright © 2025. Published by Elsevier B.V.)
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- 2025
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12. Racism and Postpartum Blood Pressure in a Multiethnic Prospective Cohort.
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Janevic T, Howell FM, Burdick M, Nowlin S, Maru S, Boychuk N, Oshewa O, Monterroso M, McCarthy K, Gundersen DA, Rodriguez A, Katzenstein C, Longley R, Whilby KW, Lee A, Cabrera C, Lewey J, Howell EA, and Levine LD
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- Humans, Female, Adult, Prospective Studies, Pregnancy, New York City epidemiology, Hypertension physiopathology, Hypertension ethnology, Hypertension, Pregnancy-Induced physiopathology, Hypertension, Pregnancy-Induced ethnology, Philadelphia epidemiology, Racism, Postpartum Period, Blood Pressure physiology
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Background: Postpartum hypertension is a key factor in racial-ethnic inequities in maternal mortality. Emerging evidence suggests that experiences of racism, both structural and interpersonal, may contribute to disparities. We examined associations between gendered racial microaggressions (GRMs) during obstetric care with postpartum blood pressure (BP)., Methods: We conducted a prospective postpartum cohort of 373 Asian, Black, and Hispanic people in New York City and Philadelphia. At delivery, we administered the GRM in obstetrics scale. We measured BP for 3 months using text-based monitoring. We estimated place-based structural racism with the Structural Racism Effect Index. We used mixed models to estimate associations between GRM and mean postpartum systolic BP and diastolic BP. We adjusted for race-ethnicity, education, body mass index, chronic hypertension (diagnosed at <20 weeks of gestation), age, and the Structural Racism Effect Index. We examined effect modification by hypertensive disorder of pregnancy and place-based structural racism., Results: A total of 4.6% of participants had chronic hypertension, 20.9% had pregnancy hypertension, and 13.4% had preeclampsia, comprising a hypertensive disorder of pregnancy subgroup (n=117). A total of 37.5% of participants experienced ≥1 GRM. Participants who experienced ≥1 GRM versus none had 1.88 mm Hg higher systolic BP from days 1 to 10 (95% CI, -0.19 to 3.95) and 2.19 mm Hg higher systolic BP from days 11 to 85 (95% CI, 0.17-4.22). Associations followed a similar pattern for diastolic BP and were stronger among the hypertensive disorder of pregnancy subgroup. Participants experiencing GRM and a high Structural Racism Effect Index had systolic BP 7.55 mm Hg (95% CI, 3.41-11.69) and diastolic BP 6.03 mm Hg (95% CI, 2.66-9.41) higher than those with neither., Conclusions: Structural racism and interpersonal racism are associated with increased postpartum BP, potentially contributing to inequities in postpartum morbidity and mortality and lifecourse cardiovascular disease., Competing Interests: None.
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- 2025
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13. Influenza Vaccination, Household Composition, and Race-Based Differences in Influenza Incidence: An Agent-Based Modeling Study.
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Williams KV, Krauland MG, Harrison LH, Williams JV, Roberts MS, and Zimmerman RK
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- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Young Adult, Black or African American statistics & numerical data, Healthcare Disparities ethnology, Healthcare Disparities statistics & numerical data, Incidence, United States epidemiology, Vaccination Coverage statistics & numerical data, White statistics & numerical data, Family Characteristics, Influenza Vaccines administration & dosage, Influenza, Human prevention & control, Influenza, Human epidemiology, Influenza, Human ethnology
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Objectives. To estimate the effect of influenza vaccination disparities. Methods. We compared symptomatic influenza cases between Black and White races in 2 scenarios: (1) race- and age-specific vaccination coverage and (2) equal vaccination coverage. We also compared differences in household composition between races. We used the Framework for Reconstructing Epidemiological Dynamics, an agent-based model that assigns US Census‒based age, race, households, and geographic location to agents (individual people), in US counties of varying racial and age composition. Results. Influenza cases were highest in counties with higher proportions of children. Cases were up to 30% higher in Black agents with both race-based and race-equal vaccination coverage. Compared with corresponding categories of White households, cases in Black households without children were lower and with children were higher. Conclusions. Racial disparities in influenza cases persisted after equalizing vaccination coverage. The proportion of children in the population contributed to the number of influenza cases regardless of race. Differences in household composition may provide insight into racial differences and offer an opportunity to improve vaccination coverage to reduce influenza burden for both races. ( Am J Public Health . 2025;115(2):209-216. https://doi.org/10.2105/AJPH.2024.307878).
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- 2025
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14. Laws Limiting Access to SNAP Benefits for People With Felony Drug Convictions: A Policy-Mapping Study.
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Shah H, McCourt AD, and Bandara S
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- Humans, United States, Substance-Related Disorders prevention & control, Food Assistance legislation & jurisprudence
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Objectives. To map US state Supplemental Nutrition Assistance Program (SNAP) bans for individuals with felony drug convictions between 2004 and 2021. Methods. Using standard legal-mapping methodology, we categorized states as maintaining the lifetime ban imposed by federal law, modifying the lifetime ban, or fully opting out of the lifetime ban in each year. Among states with modified bans in 2021, we coded types of modifications. Results. As of 2021, 26 states and the District of Columbia fully opted out of the lifetime ban, 23 states modified bans, and 1 state maintained a lifetime ban. Among states with modified bans in 2021, 13 states required compliance with parole and probation, 12 states required drug treatment, 7 states required drug testing, and 9 states limited eligibility to certain populations. Conclusions. Most states effectively de-implemented the federal lifetime ban on SNAP for people with felony drug convictions by fully opting out or modifying bans over time. However, some states still had stringent modified ban provisions. Public Health Implications. These findings underscore the need to study the effects of this patchwork of drug conviction-related ban policies on substance use and nutrition-related outcomes. ( Am J Public Health . 2025;115(2):170-177. https://doi.org/10.2105/AJPH.2024.307873).
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- 2025
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15. The Need for Culturally Tailored CKD Education in Older Latino Patients and Their Families.
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Porteny T, Kennefick K, Lynch M, Velasquez AM, Damron KC, Rosas S, Allen J, Weiner DE, Kalloo S, Rizzolo K, and Ladin K
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- Humans, Aged, United States epidemiology, Male, Female, White, Hispanic or Latino, Renal Insufficiency, Chronic therapy, Renal Insufficiency, Chronic ethnology, Patient Education as Topic methods
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Older Latino adults (aged 65+years) comprise the fastest growing minoritized group among the older population in the United States and experience a disproportionate burden of kidney failure as well as disparities in kidney care compared with non-Hispanic White individuals. Despite significant need and barriers uniquely faced by this population, few educational resources or decision aids are available to meet the language and cultural needs of Latino patients. Decision aids are designed to improve knowledge and empower individuals to engage in shared decision making and have been shown to improve decisional quality and goal-concordant care among older patients with chronic kidney disease (CKD). In this commentary, we examine the barriers faced by older Latino people with CKD who must make dialysis initiation decisions. We conclude that there is a need for culturally concordant decision aids tailored for older Latino patients with CKD to overcome barriers in access to care and improve patient-centered care for older Latino CKD patients., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2025
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16. Juvenile Injuries and Deaths From Shootings by Police in the United States, 2015-2020.
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Jackson DB, Testa A, Semenza DC, Crifasi CK, and Ward JA
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- Humans, United States epidemiology, Adolescent, Male, Female, Adult, Young Adult, Child, Gun Violence statistics & numerical data, Police, Wounds, Gunshot mortality, Crime Victims statistics & numerical data
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Purpose: The present study describes juveniles injured in fatal and nonfatal shootings by the police from 2015 to 2020, compares characteristics of juvenile victimizations to adult victimizations, and estimates the odds of a shooting victim being a juvenile v. adult, given known characteristics., Methods: From July 2021 to April 2023, we manually reviewed publicly available records on all 2015-2020 injurious shootings by the US police, identified from Gun Violence Archive. We first calculated counts and proportions of victim, incident, and response characteristics among juvenile and adult injured people, then estimated the odds of juvenile (vs. adult) victimization associated with each characteristic in multilevel logistic regression models with random intercepts to account for state- and incident-level correlation., Results: 97 percent of shootings involved presumed on-duty officers and victims whose categorical age status (i.e., juvenile or adult) was reported (n = 10,382). Included among these injured people were 317 juveniles, 33% of whom were fatally injured (mean reported juvenile age = 15.5 years). Several patterns differentiated juveniles from adult police shooting victims, including multiple demographic characteristics (e.g., race or ethnicity and gender) and the outcomes of and circumstances surrounding these events (e.g., fatality, victim weapon status, and single-officer response)., Discussion: Findings point to a critical need to identify and implement public health and policing strategies that greatly reduce the number of juveniles shot by the police every year, so that all children have the opportunity to thrive into adulthood., (Copyright © 2024 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
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- 2025
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17. Insurance remains a major source of disparity for patients with testicular cancer: call for advocacy.
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Starr S, Zhang J, Lin L, Shen J, Gamalong G, Litwin MS, Drakaki A, and Chamie K
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- Humans, Male, Retrospective Studies, Adult, United States epidemiology, Middle Aged, Insurance, Health statistics & numerical data, Medicaid statistics & numerical data, Medically Uninsured statistics & numerical data, Medicare statistics & numerical data, Socioeconomic Factors, Young Adult, Testicular Neoplasms therapy, Testicular Neoplasms mortality, Testicular Neoplasms economics, Healthcare Disparities statistics & numerical data, Healthcare Disparities economics, Insurance Coverage statistics & numerical data
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Objective: To evaluate the effects of socioeconomic factors, including insurance status, on treatment and survival for patients with testicular cancer., Patients and Methods: We extracted a retrospective cohort from the National Cancer Database that included patients diagnosed with testicular cancer 2004-2020. Competing-risks and Cox regression multivariate models including demographic, pathological, and socioeconomic covariates were constructed to evaluate receipt of treatment and death, respectively., Results: A total of 95 955 patients with testicular cancer were identified. Compared with private insurance, Medicaid (sub-distribution hazard ratio [SHR] 0.70, P < 0.001), Medicare (SHR 0.73, P < 0.001), and uninsured (SHR 0.72, P < 0.001) patients were associated with decreased likelihood of receiving chemotherapy. Compared with private insurance, Medicaid (SHR 0.55, P < 0.001), Medicare (SHR 0.76, P-value <0.001), uninsured (SHR 0.63, P-value < 0.001), and other government insurance (SHR 0.71, P = 0.010) was associated with decreased likelihood of receiving radiation. Medicaid insurance status (reference private, HR 2.60, P < 0.001) conferred the second largest hazard of death, behind having Stage III disease (reference Stage 0). Compared with private insurance, Medicare (HR 2.20, P < 0.001), no insurance (HR 2.32, P < 0.001), and other government insurance (HR 1.53, P = 0.027) statuses had higher risk of death. Patients diagnosed in Medicaid-expansion states had lower all-cause mortality (11.4% vs 13.6%, P < 0.001)., Conclusions: Testicular cancer care relies on early diagnosis and treatment. It is critically important to have a healthcare system where individuals have access to insurance and are served equitably., (© 2024 The Author(s). BJU International published by John Wiley & Sons Ltd on behalf of BJU International.)
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- 2025
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18. Cost-effectiveness analysis of a digital Diabetes Prevention Program (dDPP) in prediabetic patients.
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Park S, Ward T, Sudimack A, Cox S, and Ballreich J
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- Humans, Quality-Adjusted Life Years, Telemedicine economics, Female, Middle Aged, Male, Patient Education as Topic methods, Patient Education as Topic economics, Cost-Effectiveness Analysis, Cost-Benefit Analysis, Diabetes Mellitus, Type 2 prevention & control, Diabetes Mellitus, Type 2 economics, Prediabetic State therapy, Prediabetic State economics, Markov Chains
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Objectives: To assess the cost-effectiveness of a digital Diabetes Prevention Program (dDPP) in preventing type 2 diabetes mellitus among prediabetic patients from a health system perspective over a 10-year time horizon., Methods: A Markov cohort model was constructed to assess the cost-effectiveness of dDPP compared to a small group education (SGE) intervention. Transition probabilities for the first year of the model were derived from two clinical trials on dDPP. Transition probabilities for longer-term effects were derived from meta-analyses on lifestyle and Diabetes Prevention Program interventions. Cost and health utilities were derived from published literature. Partial completion of interventions was incorporated to provide a robust prediction of a real-world deployment. Parameter uncertainties were assessed using univariate and probabilistic sensitivity analyses. Cost-effectiveness was measured by an incremental cost-effectiveness ratio (ICER) between dDPP and SGE from a health system perspective over a 10-year time horizon., Results: The dDPP dominated the SGE at the $50,000, $100,000, and $150,000 willingness-to-pay thresholds per quality-adjusted life years (QALYs). The base case analysis at the $100,000 willingness-to-pay threshold (WTP) revealed a dominated ICER, with the SGE costing $1332 more and accruing an average of 0.04 fewer QALYs. Probabilistic sensitivity analysis showed that the dDPP was preferred in 64.4% of simulations across the $100,000 WTP thresholds., Conclusions: The findings comparing a dDPP to an SGE suggest that a dDPP can be cost-effective for patients with a high risk of developing type 2 diabetes., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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19. Medications for opioid use disorder and other evidence-based service offerings in faith-affiliated treatment centers: Implications for implementation partnerships.
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Gannon K and Warnock CA
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- Humans, Opiate Substitution Treatment, Faith-Based Organizations, Mental Health Services organization & administration, Health Services Accessibility organization & administration, Evidence-Based Practice, United States epidemiology, Opioid-Related Disorders epidemiology, Opioid-Related Disorders drug therapy, Substance Abuse Treatment Centers organization & administration
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Introduction: Amidst an ongoing surge of opioid use disorder (OUD) incidence, clinicians and policymakers are seeking partnerships with faith communities - including with faith-affiliated treatment centers (FATCs) - to expand access to evidence-based OUD treatment. However, little is known whether FATCs differentially offer such evidence-based treatment services, particularly medications for opioid use disorder (MOUD) and co-occurring mental health care., Methods: We use the 2021 National Substance Use and Mental Health Services Survey (N-SUMHSS) to examine differences in provision of several OUD services, including MOUD, psychological treatments, mental health services, medical services, recovery support services, and services related to treatment accessibility, between self-identified FATCs and non-FATCs. We also explored differences in characteristics related to insurance, licensure, and accreditation., Results: FATCs were less likely than non-FATCs to offer almost all measure of MOUD and more likely to refuse to accept clients who use MOUD. They were also less likely to report using telemedicine. However, they were more likely to offer residential treatment, Twelve Step facilitation, and transitional housing. We find little evidence that FATCs offer co-occurring mental health treatments at different rates than non-FATCs., Conclusion: More research is needed to examine the factors that drive these differences, especially in MOUD and transitional housing. When partnering with FATCs, clinicians and policymakers should seek common ground with FATCs and recognize the philosophies, values, and concerns that may potentially be driving these differences., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2025
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20. Trends in Availability and Nutritional Profile of Meat-Based Versus Meat-Free Menu Items in 75 Large Chain Restaurants in the United States, 2013-2021.
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Tucker AC, Mueller MP, Taillie LS, Block JP, Leung CW, and Wolfson JA
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- United States, Humans, Longitudinal Studies, Energy Intake, Restaurants statistics & numerical data, Restaurants trends, Nutritive Value, Meat
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Introduction: Chain restaurants are ubiquitous in the U.S. While restaurants are increasingly promoting health- and climate-conscious menu options, few studies have examined whether restaurants are increasing availability of menu items with lower climate impact and whether these offerings are healthier. This study examines trends in the availability and nutritional profile of food items featuring different meat sources on menus at 75 large chain restaurants in the U.S. from 2013 to 2021., Methods: Longitudinal data on menu items from 75 large U.S. chain restaurants from 2013 to 2021 were obtained from MenuStat.org, an online database of menu items from the largest-grossing restaurant chains in the U.S. Annual counts and proportions of food items featuring different meat sources were calculated overall, by food category, and by restaurant type. Differences in predicted mean calories between meat-based items and meat-free items were calculated (overall, by restaurant type, by year) using linear regression models with clustered standard errors., Results: Availability and calorie content of meat-based versus meat-free items were generally stable over time. Availability of chicken-containing items increased and there was an absolute reduction in the availability of beef-containing menu items (p-trends<0.001). Total calories and calories from protein, unsaturated fat, and saturated fat were lower among meat-free items versus meat-based items. However, calories from sugar were higher for meat-free items., Conclusions: While meat-free items had fewer calories and some aspects of nutritional profile were more favorable, the availability of meat-free menu items has not increased in large chain restaurants, suggesting limited improvement on reducing climate impact., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2025
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21. Medicare Accountable Care Organization Treatment of Serious Mental Illness: Associations Between Behavioral Health Integration Activities and Outcomes.
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Newton H, Colla CH, Busch SH, Tomaino M, Hardy B, Brunette MF, Agravat D, and Meara E
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- Humans, United States, Male, Female, Cross-Sectional Studies, Aged, Delivery of Health Care, Integrated organization & administration, Fee-for-Service Plans, Middle Aged, Mental Health Services statistics & numerical data, Mental Health Services organization & administration, Quality of Health Care statistics & numerical data, Accountable Care Organizations statistics & numerical data, Medicare statistics & numerical data, Mental Disorders therapy
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Objective: Characterize the association between Medicare Accountable Care Organizations' (ACOs) behavioral health integration capability and quality and utilization among adults with serious mental illness (SMI)., Background: Controlled research supports the efficacy of integrating physical and mental health care for adults with SMI, yet little is known about the organizations integrating care and associations between integration capability and quality., Methods: We surveyed Medicare ACOs (2017-2018 National Survey of ACOs, response rate 69%) and linked responses to 2016-2017 fee-for-service Medicare claims for beneficiaries with SMI. We examined the cross-sectional association between ACO-reported integration capability (tertiles of a 14-item index) and 7 patient-level quality and utilization outcomes. We fit generalized linear models for each outcome as a function of ACO integration capability, adjusting for ACO and beneficiary characteristics., Results: Study sample included 274,928 beneficiary years (199,910 unique beneficiaries) attributed to 265 Medicare ACOs. ACOs with high behavioral health integration capability (top-tertile) served more dual-eligible beneficiaries (67.8%) than bottom-tertile (63.7%) and middle-tertile ACOs (63.3%). Most beneficiaries received follow-up 30 days after mental health hospitalization and chronic disease monitoring-exceeding national quality benchmarks-but beneficiaries receiving care from top-tertile (vs bottom-tertile) ACOs were modestly less likely to receive follow-up [-2.17 percentage points (pp), P < 0.05], diabetes monitoring (-2.19 pp, P < 0.05), and cardiovascular disease monitoring (-6.07 pp, P < 0.05). Integration capability was not correlated with utilization., Conclusions: ACOs serving adults with substantial physical and mental health needs were more likely to report comprehensive integration capability but were not yet meeting the primary care needs of many adults with SMI., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2025
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22. Using human factors methods to mitigate bias in artificial intelligence-based clinical decision support.
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Militello LG, Diiulio J, Wilson DL, Nguyen KA, Harle CA, Gellad W, and Lo-Ciganic WH
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- Humans, Ergonomics, Bias, Machine Learning, Decision Support Systems, Clinical, Artificial Intelligence, Algorithms, User-Computer Interface
- Abstract
Objectives: To highlight the often overlooked role of user interface (UI) design in mitigating bias in artificial intelligence (AI)-based clinical decision support (CDS)., Materials and Methods: This perspective paper discusses the interdependency between AI-based algorithm development and UI design and proposes strategies for increasing the safety and efficacy of CDS., Results: The role of design in biasing user behavior is well documented in behavioral economics and other disciplines. We offer an example of how UI designs play a role in how bias manifests in our machine learning-based CDS development., Discussion: Much discussion on bias in AI revolves around data quality and algorithm design; less attention is given to how UI design can exacerbate or mitigate limitations of AI-based applications., Conclusion: This work highlights important considerations including the role of UI design in reinforcing/mitigating bias, human factors methods for identifying issues before an application is released, and risk communication strategies., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2025
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23. Global predictors of tracheostomy-related pressure injury in the COVID-19 era: A study of secondary data.
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Moser CH, Budhathoki C, Allgood SJ, Haut ER, Brenner MJ, and Pandian V
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- Humans, Male, Female, Risk Factors, Adult, Middle Aged, Incidence, Child, Aged, United States epidemiology, SARS-CoV-2, Child, Preschool, United Kingdom epidemiology, Adolescent, Tracheostomy adverse effects, Tracheostomy statistics & numerical data, COVID-19 epidemiology, Pressure Ulcer epidemiology, Pressure Ulcer etiology
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Objectives: To determine the incidence and risk factors of tracheostomy-related pressure injuries (TRPI) and examine the COVID-19 pandemic's impact on TRPI incidence., Design: Secondary analysis of Global Tracheostomy Collaborative database and a multi-center hospital system's electronic medical records., Setting: 27 hospitals, primarily in the United States, United Kingdom, and Australasia., Patients: 6,400 adults and 2,405 pediatric patients hospitalized with tracheostomy between 1 January 2019 and 31 December 2021., Measurement: TRPI as a binary outcome, reported as odds ratios., Results: TRPI incidence was 4.69 % in adults and 5.65 % in children. For adults, associated risks were female sex (OR: 0.64), severe obesity (OR: 2.62), ICU admission (OR: 2.05), cuffed tracheostomy (OR: 1.49), fenestrated tracheostomy (OR: 15.37), percutaneous insertion (OR: 2.03) and COVID-19 infection (OR: 1.66). For children, associated risks were diabetes mellitus (OR: 4.31) and ICU admission (OR: 2.68). TRPI odds increased rapidly in the first 60 days of stay. Age was positively associated with TRPI in adults (OR: 1.014) and children (OR: 1.060). Black patients had higher TRPI incidence than white patients; no moderating effects of race were found. Hospital cluster effects (adults ICC: 0.227; children ICC: 0.138) indicated unmeasured hospital-level factors played a significant role., Conclusions: Increasing age and length of stay up to 60 days are TRPI risk factors. Other risks for adults were female sex, severe obesity, cuffed/fenestrated tracheostomy, percutaneous insertion, and COVID-19; for children, diabetes mellitus and FlexTend devices were risks. Admission during the COVID-19 pandemic had contrasting effects for adults and children. Additional research is needed on unmeasured hospital-level factors., Implications for Clinical Practice: These findings can guide targeted interventions to reduce TRPI incidence and inform tracheostomy care during public health crises. Hospital benchmarking of tracheostomy-related pressure injuries is needed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Ltd.)
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- 2025
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24. Estimating anticipatory, immediate, and delayed effects of disability registration on depressive symptoms.
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Park GR, Namkung EH, and Kim J
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- Humans, Male, Female, Republic of Korea, Middle Aged, Adult, Anticipation, Psychological, Sex Factors, Depression psychology, Aged, Persons with Disabilities psychology
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Purpose: This study examines (a) whether disability registration has anticipatory, immediate, and delayed effects on depressive symptoms and (b) how these effects differ by gender., Research Method/design: Using data from the Korea Welfare Panel Study spanning over 16 waves between 2005 and 2020, this study employed the individual-level fixed effects models to estimate the trajectories of depressive symptoms before and after the registration of physical disability, for a cohort of 20,054 individuals. Furthermore, gender-stratified fixed effects models were used to examine gender differences., Results: Compared to the preregistration reference period (i.e., 4 or more years before disability registration), there was a sustained rise in depressive symptoms leading up to the year of registration, indicating the presence of anticipatory effects. After disability registration, depressive symptoms consistently remained at a statistically higher level than during the initial reference period, with a gradual return to the baseline level of depressive symptoms over time. These anticipatory, immediate, and delayed effects of disability registration were notably more pronounced among men than women., Conclusion/implications: To develop more effective mental health interventions for people with disability, policymakers should consider gendered trajectories of depressive symptoms before and after disability registration. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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- 2025
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25. Projected Impact of Replacing Juice With Whole Fruit in Early Care and Education.
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Zaltz DA, Weir BW, Neff RA, and Benjamin-Neelon SE
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- Humans, Female, Child, Preschool, Male, Infant, Energy Intake, United States, Child Day Care Centers, Dietary Fiber administration & dosage, Fruit, Fruit and Vegetable Juices
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Introduction: The purpose of this study was to simulate potential changes in dietary intake and food costs by replacing juice with whole fruit among children ages 1-5 years attending U.S. early care and education settings between 2008 and 2020., Methods: Estimated mean changes in daily intake of calories, sugar, fiber, calcium, vitamin C and overall food costs under plausible scenarios of replacing juice with whole fruit. Researchers fit hierarchical regression with children nested within early care and education nested within studies, adjusting for potential confounders., Results: The sample consisted of 6,304 days of direct observation (90% aged 2 years or older, 51% female, 38% Black/African American) in 846 early care and education facilities (73% centers, 75% Child and Adult Care Food Program participants). Replacing juice with whole fruit would reduce energy intake by 8.2-27.3 kcal/day, reduce sugar by 3.4-5.6 g/d, increase fiber by 0.5-1.3 g/d, and have negligible impact on vitamin C and calcium. Replacing juice with whole fruit in early care and education would increase per-child daily food costs between $0.44 and 0.49, representing an increase from 3.8% for juice to approximately 9.8%-10.7% for whole fruit as a percent of total food costs., Conclusions: Replacing juice with whole fruit in early care and education would result in increased fiber intake and decreased sugar and calories. A policy to replace juice with whole fruit in early care and education would likely cause an increased daily food cost and given the potential broad benefit of this dietary intervention, there may be reason to expand funding within nutrition assistance programs in early care and education., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2025
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26. Developing Infectious Disease Outbreak Emergency Communications for Populations With Limited English Proficiency: Insights to Sustain Collaborations Between Local Health Departments and Community-Based Organizations.
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SteelFisher GK, Caporello HL, Stein RI, Lubell KM, Lane L, Moharam Ali S, Briseño L, Dicent Taillepierre J, Rodriguez-Lainz A, Boyea A, Espino L, and Aveling EL
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- Humans, United States, SARS-CoV-2, Qualitative Research, Local Government, Cooperative Behavior, Communication, Interviews as Topic, COVID-19 epidemiology, COVID-19 prevention & control, Disease Outbreaks prevention & control, Limited English Proficiency
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Purpose: State and local public health departments (LHDs) are encouraged to collaborate with community-based organizations (CBOs) to enhance communication and promote protective practices with communities made vulnerable during emergencies, but there is little evidence-based understanding of practical approaches to fostering collaboration in this context. This research focuses on how collaboration enhances LHD capacity for effective communication for people with limited English proficiency (LEP) during infectious disease outbreaks specifically and strategies to facilitate productive LHD-CBO collaboration., Design: Qualitative, telephone interviews, conducted March-October 2021., Setting: Rural and urban jurisdictions with Chinese-speaking or Spanish-speaking populations across the United States., Participants: 36 LHD and 31 CBO staff working on outreach to Chinese and Spanish speakers during COVID-19., Method: Interviews were audio-recorded, transcribed verbatim, and analyzed using a team-based, codebook approach to thematic analysis., Results: During COVID-19, CBOs extended LHD capacity to develop and disseminate effective communication, meaning communication that is rapidly in-language, culturally resonant, locally relevant, and trusted. Practical strategies to enable and sustain effective collaboration were needed to address operational dimensions (eg, material and administrative) and relational dimensions (eg, promoting trust and respect)., Conclusion: Policies and financing to support LHD-CBO collaborations are critical to improving communication with people with LEP and addressing long-standing inequities in outcomes during outbreaks., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: GKS’s husband is part owner of a consulting firm that has done work for a pharmaceutical company within the past 3 years.
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- 2025
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27. Toward an artificial intelligence code of conduct for health and healthcare: implications for the biomedical informatics community.
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Payne PRO, Johnson KB, Maddox TM, Embi PJ, Mandl KD, McGraw D, Saria S, and Adams L
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- Humans, United States, Delivery of Health Care, Artificial Intelligence ethics, Medical Informatics ethics, Codes of Ethics
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Introduction: The rapid advancement of artificial intelligence (AI) has led to significant transformations in health and healthcare. As AI technologies continue to evolve, there is an urgent need to establish a unified framework that guides the design, implementation, and evaluation of AI-driven interventions across individual and population health contexts., Approach: In response to this need, the National Academy of Medicine (NAM) has initiated the development of an AI code of conduct (AICC) through its Digital Health Action Collaborative. This code of conduct is grounded in shared principles and commitments, aiming to actualize ethical and effective AI practices within the broader health and healthcare ecosystem. Given its specialized expertise and insight, the biomedical informatics (BMI) community plays a pivotal role in shaping and applying these guidelines., Recommendations: We, as members of the AICC Steering Committee and the NAM Digital Health Action Collaborative, urge BMI educators, researchers, and practitioners to engage actively in refining and implementing the AICC. This involvement is critical to ensuring that the code is robust, applicable, and continuously improved to meet the evolving challenges facing health and healthcare., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2025
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28. Navigating Disagreements on Health Information: How Patients With Cancer Perceive Health Care Providers' Approaches to Discussing Patient-Identified Information.
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Fridman I, Smith C, Barrett A, Johnson S, Bhowmick A, Hayes S, and Elston Lafata J
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Purpose: Although publicly available cancer-related information online and offline could help patients make informed decisions, it also poses challenges due to prevalent misinformation. Patients need proper provider guidance to ensure they use valid and relevant information in decisions. We identify effective communication approaches for providers when (1) discussing patient-identified information and (2) disagreeing with it., Methods: From June to August 2023, people living with cancer were reached via online communities and asked first about their actual experiences discussing patient-identified information with their providers. Respondents were then randomly assigned into an experiment with three hypothetical scenarios where providers disagreed with patient-identified information. Provider responses included (1) dismissal, (2) explanation, and (3) explanation with relationship-building elements. Pearson correlation and multivariable analysis of variance were used to evaluate differences in patient perceptions., Results: One hundred seventy-five respondents completed the survey. Mean age: 53 years; 45% female; and 88% White, 10% Black, and 2% others. Forty-six percent held Bachelor's degrees or higher, 11% lived rurally, 36% reported financial difficulties, and 46% rated their health as good/excellent. Between 31% and 37% of respondents reported their provider used communication approaches that negatively correlated with discussion outcomes. The approaches included avoidance of such conversations due to limited time, discouragement of future information searches, or judgmental comments. In the experiment, respondents randomly assigned to receive relationship-building elements were significantly more comfortable sharing information, felt more satisfied, respected, and trusted their provider's opinion more than those receiving the dismissal scenario. The explanation scenario was not perceived differently compared with the dismissal scenario., Conclusion: More than a third of respondents reported negative communication when sharing patient-identified information with their provider. Provider prioritization of relationship-building alongside explanations could foster trust and facilitate open information exchange, supporting informed decisions.
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- 2025
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29. Addressing racial and ethnic disparities in premature exits from permanent supportive housing among residents with substance use disorders.
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Panadero TJ, Gabrielian S, Seamans MJ, Gelberg L, Tsai J, and Harris T
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- Humans, Female, Male, United States epidemiology, Middle Aged, Adult, Public Housing statistics & numerical data, Los Angeles, Ethnicity statistics & numerical data, Ethnicity psychology, Substance-Related Disorders ethnology, Ill-Housed Persons statistics & numerical data, United States Department of Veterans Affairs, Veterans statistics & numerical data, Veterans psychology
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Background: Permanent supportive housing (PSH) is an evidence-based practice for reducing homelessness that subsidizes permanent, independent housing and provides case management-including linkages to health services. Substance use disorders (SUDs) are common contributing factors towards premature, unwanted ("negative") PSH exits; little is known about racial/ethnic differences in negative PSH exits among residents with SUDs. Within the nation's largest PSH program at the Department of Veterans Affairs (VA), we examined relationships among SUDs and negative PSH exits (for up to five years post-PSH move-in) across racial/ethnic subgroups., Methods: We used VA administrative data to identify a cohort of homeless-experienced Veterans (HEVs) (n = 2,712) who were housed through VA Greater Los Angeles' PSH program from 2016-2019. We analyzed negative PSH exits by HEVs with and without SUDs across racial/ethnic subgroups (i.e., African American/Black, Non-Hispanic White, Hispanic/Latino, and Other/Mixed [Asian, American Indian or Alaskan Native, and Native Hawaiian or Other Pacific Islander, and mixed race/ethnicity]) in controlled models and accounting for competing risk of death., Results: In competing risk models, HEVs with at least one SUD had 1.3 times the hazard of negative PSH exits compared to those without SUDs (95% CI: 1.00, 1.61). When stratifying by race/ethnicity, Other/Mixed race residents with at least one SUD had 6.4 times the hazard of negative PSH exits compared to their peers without SUDs (95% CI: 1.61-25.50). Hispanic/Latino residents with at least one SUD had 1.9 times the hazard compared to those without SUDs; however, this association was not statistically significant (95% CI: 0.85-4.37). African American/Black residents with at least one SUD had 1.2 times the hazard compared to those without SUDs (95% CI: 0.85-1.64), indicating no evidence of an association with negative PSH exits. Non-Hispanic White residents with at least one SUD had 1.1 times the hazard compared to those without SUDs (95% CI: 0.75-1.66), similarly indicating no evidence to suggest an association with negative PSH exits., Conclusions: These findings suggest relationships between SUDs and negative PSH exits differ between racial/ethnic groups and suggest there may be value in culturally specific tailoring and implementation of SUD services for these subgroups., Competing Interests: Declarations. Ethics approval and consent to participate: All study procedures were reviewed and approved by Department of Veteran Affairs Greater Los Angeles’ Institutional Review Board (IRB) (Reference number: 1630424–1) as constituting quality improvement. The present study involved secondary analysis of existing data from Veteran medical records and no more than minimal risk; as such, the need for participant informed consent to participate was waived by the IRB. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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- 2025
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30. Patterns of willingness to share health data with key stakeholders in US consumers: a latent class analysis.
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Nagappan A and Zhu X
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Objective: To identify distinct patterns in consumer willingness to share health data with various stakeholders and analyze characteristics across consumer groups., Materials and Methods: Data from the Rock Health Digital Health Consumer Adoption Survey from 2018, 2019, 2020, and 2022 were analyzed. This study comprised a Census-matched representative sample of U.S. adults. Latent class analysis (LCA) identified groups of respondents with similar data-sharing attitudes. Groups were compared by sociodemographics, health status, and digital health utilization., Results: We identified three distinct LCA groups: (1) Wary (36.8%), (2) Discerning (47.9%), and (3) Permissive (15.3%). The Wary subgroup exhibited reluctance to share health data with any stakeholder, with predicted probabilities of willingness to share ranging from 0.07 for pharmaceutical companies to 0.34 for doctors/clinicians. The Permissive group showed a high willingness, with predicted probabilities greater than 0.75 for most stakeholders except technology companies and government organizations. The Discerning group was selective, willing to share with healthcare-related entities and family (predicted probabilities >0.62), but reluctant to share with other stakeholders (predicted probabilities <0.29). Individual characteristics were associated with LCA group membership., Discussion: Findings highlight a persistent trust in traditional healthcare providers. However, the varying willingness to share with non-traditional stakeholders suggests that while some consumers are open to sharing, others remain hesitant and selective. Data privacy policies and practices need to recognize and respond to multifaceted and stakeholder-specific attitudes., Conclusion: LCA reveals significant heterogeneity in health data-sharing attitudes among U.S. consumers, providing insights to inform the development of data privacy policies., (© The Author(s) 2025. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2025
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31. Addressing tobacco-related disparities through tobacco treatment research: a roadmap with worked examples.
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Hartmann-Boyce J
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- 2025
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32. Diabetes disparities in diabetes health care access and outcomes during the COVID-19 pandemic in the United States.
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Zhong L, Ma Y, Ionova Y, Bhatt A, Vargas R, Banh T, and Wilson L
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Objectives: To investigate the impact of COVID-19 on hospitalization and consequent diabetes-related complications in patients with type 2 diabetes mellitus (diabetes)., Methods: We conducted a retrospective cohort study of patients with diabetes. Interrupted time series analysis (ITS) was used to analyze the monthly trends in diabetes-related hospitalization rates, including short- and long-term complications, 1-year before and after onset of COVID-19., Results: Persons with diabetes experienced a significant ( p < 0.001) rapid drop in monthly hospital admission rates at onset of COVID-19, then rose significantly ( p = 0.003) to higher than pre-COVID-19 levels. Older age, lower education, and income levels were associated with higher base-level monthly hospital admission rates and a greater rate reduction at COVID-19 onset. ITS analysis showed monthly hospital admission rates from short-term complications surged to higher level 6 months after COVID-19 onset. Hospital admissions due to long-term complications decreased immediately post-COVID-19, but rose significantly ( p < 0.001) to higher than pre-COVID levels, with patients experiencing higher nephropathy, angiography, and dermatological complications post-COVID-19., Conclusion: COVID-19 had a negative impact on diabetes-related hospitalization access, resulting in increased short- and long-term complications. Long-term effects of deferred care due to COVID-19 on diabetes-related complications may persist, emphasizing the need for continued education toward improved diabetes self-management.
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- 2025
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33. Medicaid coverage continuity is associated with lymphoma stage among children and adolescents/young adults.
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Zhang XE, Castellino SM, Yabroff KR, Stock W, Cornwell P, Bai S, Mertens AC, Lipscomb J, and Ji X
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Abstract: Lymphoma is the third leading cause of cancer among children and adolescents/young adults (AYAs) in the United States, with later-stage diagnoses often being linked to worse outcomes. Continuous health insurance coverage is crucial for facilitating early cancer detection and diagnosis. Among Medicaid-insured children and AYAs diagnosed with lymphoma, this study examines whether the timing of Medicaid enrollment and coverage continuity are associated with stage at diagnosis. Using the Surveillance, Epidemiology, and End Results-Medicaid data, we identified children and AYAs (aged 0-39 years) newly diagnosed with lymphoma between 2007 and 2013 in 12 states that were linked to the administrative Medicaid data. Medicaid enrollment patterns were categorized into continuous Medicaid (preceding and through diagnosis), newly gained Medicaid (at or shortly after diagnosis), and other Medicaid enrollment patterns. Late-stage disease was defined as Ann Arbor stage IV (vs stage I-III). Multiple logistic regressions were estimated, with marginal effects (MEs) reported. Of 3524 patients identified, 37.8% had continuous Medicaid, followed by newly gained Medicaid (35.2%) and other Medicaid enrollment patterns (27.0%). Compared with patients continuously enrolled in Medicaid, those with newly gained Medicaid and with other Medicaid enrollment patterns were 54% (ME, 13.9 percentage points [ppt]; 95% confidence interval [CI], 8.5-19.2; P < .001) and 18% (ME, 4.6 ppt; 95% CI, 2.2-7.0; P < .001) more likely to present with stage IV lymphoma, respectively. Overall, having continuous Medicaid coverage before diagnosis was associated with a lower likelihood of late-stage lymphoma at diagnosis; however, only 3 in 8 Medicaid-insured children and AYAs with lymphoma were continuously enrolled in Medicaid before their diagnosis., (© 2025 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
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- 2025
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34. Beyond Food Assistance: A Scoping Review Examining Associations of Nonfood Social Safety Net Programs in the United States With Food Insecurity and Nutrition Outcomes.
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Duffy EW, Poole MK, Gonzalez D, Petimar J, Kinsey EW, Shafer PR, Baldwin-SoRelle C, and Austin AE
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Objective: To conduct a scoping review to summarize the state of the evidence on associations between participation in nonfood social safety net programs (eg, income assistance, housing assistance) in the United States and food- and nutrition insecurity-related outcomes., Background: Food and nutrition insecurity are persistent public health challenges in the United States that increase chronic disease risk and exacerbate health disparities. Several food assistance programs enhance food and nutrition security. Nonfood social safety net programs, however, may also improve these outcomes by relieving households' financial strain. Understanding the scope of research on nonfood social safety net programs' associations with not only food insecurity but also nutrition insecurity is needed to understand their potential to reduce the burden of diet-related chronic disease., Methods: Six databases were systematically searched for peer-reviewed articles. Articles were included if they were published between 1995 and 2023; conducted in the United States; available in English; included a dependent variable of food- and/or nutrition insecurity-related measures; and included an independent variable of participation in a federally funded, nonfood social safety net program., Results: Included articles (n = 65) reported on studies that examined 10 unique social safety net programs; 8 studies examined program interactions. Twenty studies focused on COVID-19 pandemic-era programs. Fifty-eight studies used food insecurity, food insufficiency, or food hardship as outcomes, and 11 studies used nutrition insecurity-related outcomes. Overall, results suggest that participation in nonfood social safety net programs is associated with reductions in food insecurity. Current evidence for an association between program participation and nutrition insecurity-related outcomes is limited., Conclusion: Further research is warranted on the association between nonfood social safety net programs and nutrition insecurity; potential interactions between social safety net programs; associations between the expiration of pandemic-era programs and food and nutrition insecurity; and how program impacts might differ among populations with persistent disparities in food and nutrition insecurity., (© The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2025
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35. Success and failure in establishing national physician databases: a comparison between Canada and Israel.
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Levi B, Davidovitch N, and Allin S
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Physician databases constitute an essential component of health workforce planning. However, while some countries have established functioning national physician databases, others have failed to do so. We compared the healthcare systems of two technologically and economically developed countries, Canada and Israel, which represent cases of respective success and failure in establishing physician databases. A comparative analysis was conducted using a historical-institutionalist approach to examine contemporary health policy outcomes. White papers, studies on healthcare human resources, and reports by professional committees were examined to explore the aims, interests, positions, and actions of stakeholders. In Canada, state-medical profession cooperation, deep-rooted in a longstanding regulatory bargain between the two parties, has facilitated the creation and management of physician databases, albeit limited and in need of urgent improvement, on national and jurisdictional levels. The lack of such regulatory arrangement coupled with enduring conflicted relations between stakeholders due to particular historical developments have hindered the development of an Israeli equivalent database so far. Finally, health policy outcomes may be explained against the backdrop of broader political, governance, and organisational contexts. How medical organisations respond to governmental healthcare initiatives is heavily influenced by their institutional position vis-à-vis the state, shaped by historical processes and regulatory arrangements.
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- 2025
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36. A Unique Simulation Methodology for Practicing Clinical Decision Making.
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Amar S and Bitan Y
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Background: While bedside teaching offers invaluable clinical experience, its availability is limited. Challenges such as a shortage of clinical placements and qualified teaching physicians, coupled with increasing medical student numbers, exacerbate this issue. Simulation-based learning encompasses varied educational values and has the potential to serve as an important tool in medical students' education., Objectives: In this study, we evaluate a new Clinical Decision Making Integrated Digital Simulation (CDMIDS) method that was developed in order to enhance the clinical decision-making competency and self-confidence of medical students early in their clinical training through practicing fundamental core skills., Methods: The study compares 108 4th-year medical students' questionnaire responses pre-/postself-assessments following practice of a new clinical decision-making simulation methodology., Results: Results indicate a positive participant experience, with the simulation perceived as a valuable platform for practicing integrated bedside decision making. Notably, participants demonstrated a statistically significant increase in willingness to make clinical decisions. The simulation contributed to enhanced knowledge, professional skills, and self-confidence in clinical decision making., Conclusion: The use of a CDMIDS method integrates clinical decision making as part of early medical school curriculum. Moreover, the method boosts learners' professional confidence, self-directed learning, and additional experiences. The method is flexible and can be applied in any medical school, especially those with limited resources, by making specific, localized modifications., Competing Interests: The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2025.)
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- 2025
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37. Enhancing Diagnostic Accuracy of Lung Nodules in Chest Computed Tomography Using Artificial Intelligence: Retrospective Analysis.
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Liu W, Wu Y, Zheng Z, Bittle M, Yu W, and Kharrazi H
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- Humans, Retrospective Studies, Middle Aged, Female, Male, Lung Neoplasms diagnostic imaging, Lung Neoplasms diagnosis, Aged, Adult, Artificial Intelligence, Tomography, X-Ray Computed methods, Tomography, X-Ray Computed statistics & numerical data
- Abstract
Background: Uncertainty in the diagnosis of lung nodules is a challenge for both patients and physicians. Artificial intelligence (AI) systems are increasingly being integrated into medical imaging to assist diagnostic procedures. However, the accuracy of AI systems in identifying and measuring lung nodules on chest computed tomography (CT) scans remains unclear, which requires further evaluation., Objective: This study aimed to evaluate the impact of an AI-assisted diagnostic system on the diagnostic efficiency of radiologists. It specifically examined the report modification rates and missed and misdiagnosed rates of junior radiologists with and without AI assistance., Methods: We obtained effective data from 12,889 patients in 2 tertiary hospitals in Beijing before and after the implementation of the AI system, covering the period from April 2018 to March 2022. Diagnostic reports written by both junior and senior radiologists were included in each case. Using reports by senior radiologists as a reference, we compared the modification rates of reports written by junior radiologists with and without AI assistance. We further evaluated alterations in lung nodule detection capability over 3 years after the integration of the AI system. Evaluation metrics of this study include lung nodule detection rate, accuracy, false negative rate, false positive rate, and positive predictive value. The statistical analyses included descriptive statistics and chi-square, Cochran-Armitage, and Mann-Kendall tests., Results: The AI system was implemented in Beijing Anzhen Hospital (Hospital A) in January 2019 and Tsinghua Changgung Hospital (Hospital C) in June 2021. The modification rate of diagnostic reports in the detection of lung nodules increased from 4.73% to 7.23% (χ
2 =12.15; P<.001) at Hospital A. In terms of lung nodule detection rates postimplementation, Hospital C increased from 46.19% to 53.45% (χ1 =25.48; P<.001) and Hospital A increased from 39.29% to 55.22% (χ2 1 =25.48; P<.001) and Hospital A increased from 39.29% to 55.22% (χ2 =53.48; P<.001). The detection accuracy demonstrated a decrease from 93.33% to 92.23% for Hospital A and from 95.27% to 92.77% for Hospital C. Regarding the changes in lung nodule detection capability over a 3-year period following the integration of the AI system, the detection rates for lung nodules exhibited a modest increase from 54.6% to 55.84%, while the overall accuracy demonstrated a slight improvement from 92.79% to 93.92%.1 =122.55; P<.001). At Hospital A, the false negative rate decreased from 8.4% to 5.16% (χ2 1 =9.85; P=.002), while the false positive rate increased from 2.36% to 9.77% (χ2 1 =53.48; P<.001). The detection accuracy demonstrated a decrease from 93.33% to 92.23% for Hospital A and from 95.27% to 92.77% for Hospital C. Regarding the changes in lung nodule detection capability over a 3-year period following the integration of the AI system, the detection rates for lung nodules exhibited a modest increase from 54.6% to 55.84%, while the overall accuracy demonstrated a slight improvement from 92.79% to 93.92%., Conclusions: The AI system enhanced lung nodule detection, offering the possibility of earlier disease identification and timely intervention. Nevertheless, the initial reduction in accuracy underscores the need for standardized diagnostic criteria and comprehensive training for radiologists to maximize the effectiveness of AI-enabled diagnostic systems., (©Weiqi Liu, You Wu, Zhuozhao Zheng, Mark Bittle, Wei Yu, Hadi Kharrazi. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 27.01.2025.)- Published
- 2025
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38. Competency Gaps Among Governmental Public Health Employees With and Without a Formal Public Health Degree: Where Are We Now?
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Gee M, Taylor H, and Yeager VA
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Objective: The purpose of this study is to examine whether differences in self-reported core competency skill gaps among U.S. governmental public health workers with and without a formal degree in public health have changed since the last assessment in 2017., Design: This cross-sectional study utilizes data from the 2021 Public Health Workforce Interests and Needs Survey (PH WINS). Bivariate relationships were analyzed by conducting chi-square tests of respondents' supervisory level and reported skill gaps. Multivariate logistic regressions of reported skill gaps were performed holding gender, age, race/ethnicity, public health certificate attainment, role type, current employer, and tenure in public health practice constant., Setting: A nationally representative sample of U.S. government public health employees., Participants: 36,752 U.S. governmental public health employees across local and state health agencies representing 47 states., Main Outcome Measures: Self-reported competency skills gaps., Results: In 2021, among both nonsupervisors and supervisors, having a formal public health degree (bachelors, masters, or doctorate) was significantly associated with reduced odds of reporting a skill gap across more than half of the competency skills assessed (14 of 23 skills and 17 of 24 skills, respectively). Nonsupervisors and supervisors with a formal public health degree had fewer skill gaps in 2021 than in 2017. Furthermore, whereas in 2017, when having a public health degree had no effect on executives reporting a skill gap, in 2021, having a public health degree was significantly associated with reduced odds of reporting 2 skill gaps., Conclusions: Overall, across all position levels (ie, nonsupervisory, supervisor, executive), public health workers with a public health degree experienced fewer competency skill gaps in 2021 than in 2017. These findings from PHWINS 2021 illustrate that formal public health education generally decreases competency gaps across numerous competency domains. However, the variability in reported gaps across supervisory levels shows the need for ongoing evaluation and adaptation of formal public health degree programs., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2025
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39. Tobacco product flavour policies in the USA.
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Whitacre TR, Crippen A, Monthrope M, Narine T, Liber AC, and Friedman AS
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Objectives: Characterise US residents' exposure to restrictions on sales of flavoured electronic nicotine delivery system (ENDS), cigars and menthol cigarettes across states and time, and assess correlations between these policies., Methods: From 2022 to 2024, we compiled flavour policy locations from advocacy groups and online searches, located corresponding legal texts and reviewed these to identify policy details, including effective dates. Using census data, we calculated the proportion of state residents covered by each policy quarterly from 2009 to 2024 and estimated correlations between them and cigarette taxes., Results: By January 2024, menthol cigarettes, flavoured cigars and flavoured ENDS sales restrictions covered 17.6%, 18.1% and 28.1% of US residents. About 1 in 10 US residents is subject to flavoured ENDS restrictions without concurrent restrictions on flavoured cigar and menthol cigarette sales. Strong correlations between flavour policy coverage and cigarette tax rates indicate a need to adjust for exposure to a range of tobacco control policies in analyses evaluating any one of these regulations' effects., Conclusions: While state and local adoption of restrictions on flavoured tobacco product sales has proliferated, flavour policy coverage for combustible tobacco products lags well behind that for ENDS. If this leads some people who vape flavoured ENDS to substitute towards flavoured cigars and/or menthol cigarettes, this policy combination could harm population health., Policy Implications: Rapid implementation of proposed US Food and Drug Administration rules barring flavoured cigar and menthol cigarette sales is needed to ensure that regulation of more lethal, combustible tobacco products is not more lenient than restrictions on less harmful nicotine products., Competing Interests: Competing interests: No, there are no competing interests., (© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.)
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- 2025
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40. Prioritizing implementation solutions for the urban family physician policy in Iran: a multi-criteria decision-making study.
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Shams L, Mobinizadeh M, Nasiri T, and Mohammadi F
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- Iran, Humans, Interviews as Topic, Physicians, Family psychology, Decision Making, Health Policy, Family Practice organization & administration, Qualitative Research
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Background: Family physician program is one of the effective reforms of the health system in Iran, but despite the implementation of this program in rural areas and the passage of ten years since its implementation in two provinces of Fars and Mazandaran, its implementation has faced problems. The aim of this study is to identify and prioritize implementation solutions related to the challenges of the family physician program in Iran., Methods: This is a qualitative study using semi-structured interviews with 22 snowball-sampled experts and managers of basic health insurers to extract problems and executive solutions through coding and data analysis using Atlas Ti software and content analysis in the first stage. The combined criteria were used to report qualitative studies (COREQ). In the second stage, the extracted executive solutions were ranked using multi-criteria decision-making (MADM) and a hybrid approach combining Shannon entropy with simple aggregation weighting (SAW)., Results: Main themes were identified, including financing, management, human resources, structure, culture building, payment mechanism information systems, monitoring & control, performance of insurance organisations, and implementation. Out of these, priority was given to the information system, along with 41 sub-themes prioritising comprehensive, community-oriented physician training., Conclusion: The findings of the study provide remedies for the problems of the Iranian Urban Family Physician Programme at the executive level and in priority order, from the standpoint of the insurance organisations. Making crucial decisions entails handling matters relating to funding, administration, personnel, architecture, ethos, remuneration, IT systems, oversight, insurance organization output, and execution., Competing Interests: Declarations. Ethics approval and consent to participate: The research purpose and methodology were reviewed and approved by the Internal Research Ethics Committee of Shahid Beheshti University of Medical Sciences (IR.SBMU.SME.REC.1400.025). Informed consent was obtained from all the participants. The informants gave written informed consent to participate after receiving written and verbal information about the study. Participation was voluntary, and the participants could withdraw at any time before publication without consequences. The study was conducted in accordance to relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)
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- 2025
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41. Association between prenatal depressive symptoms and receipt of recommended maternal and infant care postpartum.
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Masters C, Carandang RR, Rojina JA, Lewis JB, Ickovics JR, Cunningham SD, and Hagaman A
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Background: Maternal mental health can impact health care access and utilization for both the birthing parent and infant. We examined the association between prenatal depressive symptoms (episodic and chronic) and receipt of the postpartum 6-week visit and infant vaccinations in the first year postpartum., Methods: Postpartum individuals (N = 672) who attended Expect With Me group prenatal care in Nashville, Tennessee and Detroit, Michigan completed surveys during the second and third trimesters of pregnancy, as well as 6- and 12- months postpartum. We conducted multiple logistic regression to examine associations between prenatal depressive symptoms and attendance at the six-week postpartum check-up, and infant receipt of recommended vaccinations by 12 months, controlling for potential confounders., Results: During pregnancy, 17.0 % of individuals experienced episodic depression, and 6.4 % experienced chronic depression. Individuals with chronic prenatal depression were less likely to receive their six-week postpartum check-up compared to those without chronic prenatal depression (Adjusted Odds Ratio [AOR] 0.55; 95 % confidence interval [CI] = 0.31, 0.99). No significant association was found for patients with episodic or chronic prenatal depression and the likelihood of infants receiving all recommended vaccines by 12 months old., Conclusions: Chronic prenatal depression was associated with not receiving recommended six-week postpartum healthcare, which is essential to detect postpartum complications and address family planning. We did not observe impacts of maternal depression on infant receipt of vaccines. Maternal mental health intervention is warranted to ensure birthing parents receive the necessary support and treatment for overall well-being., Competing Interests: Declaration of competing interest This research was generously supported by a grant from UnitedHealth Foundation, with additional in-kind support from UnitedHealth Group. UnitedHealth Group contributed to study design and data collection protocols. UnitedHealth Foundation and UnitedHealth Group had no role in data analysis and interpretation nor writing of this report. There are no other conflicts of interest to report., (Copyright © 2025. Published by Elsevier B.V.)
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- 2025
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42. Medical Care or Deportation: Examining Interior Border Checkpoints and Access to Higher-Level Medical Care for Undocumented Immigrants in South Texas.
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Blackburn CC, Rico M, Hernandez J, and Lee M
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We examined the impacts of interior border checkpoints on access to higher-level medical care via ground ambulance for undocumented immigrants in South Texas. Using purposive sampling, we conducted interviews (n = 30) with ground ambulance personnel in the lower Rio Grande Valley, Texas. Procedures implemented in 2018 mandate that hospitals notify Border Patrol of a patient's legal status before transfer. Undocumented immigrants cannot access higher-level medical care through ground ambulance transport without notifying Border Patrol. ( Am J Public Health . Published online ahead of print January 23, 2025:e1-e4. https://doi.org/10.2105/AJPH.2024.307927).
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- 2025
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43. Impacts of State COVID-19 Vaccine Mandates for Health Care Workers on Health Sector Employment in the United States.
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Wang Y, Callison K, Hernandez JH, and Stoecker C
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Objectives. To assess the impact of state COVID-19 vaccine mandates for health care workers (HCWs) on health sector employment in the United States. Methods. Using monthly state-level employment data from the Quarterly Census of Employment and Wages between January and October 2021, we employed a partially pooled synthetic control method that accounted for staggered mandate adoption and heterogeneous treatment effects. We conducted analyses separately for the 4 health care subsectors-ambulatory health care services, hospitals, nursing and residential care, and social assistance-with an additional analysis of 2 industry groups-skilled nursing care and community care for the elderly-under the nursing and residential care subsector. We further explored possible heterogeneous impacts according to the test-out option availability. Results. Mandate impact estimates were statistically indistinguishable from zero. Results further ruled out a mandate-associated decrease in employment larger than 2.1% of premandate employment levels for the 6 health care domains examined and for states with no test-out option. Conclusions. State COVID-19 vaccine mandates for HCWs were not found to be associated with significant adverse impacts on health sector employment even in states without a testing alternative to vaccination. The findings support vaccine mandates as a viable preventive measure without material disruption to the health care workforce, including in times of public health emergencies. ( Am J Public Health . Published online ahead of print January 23, 2025:e1-e5. https://doi.org/10.2105/AJPH.2024.307906).
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- 2025
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44. Ten-Year Medicare Use and Spending on the 10 Drugs Selected for Negotiation Under the Inflation Reduction Act.
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Essa M, Ross JS, Dhruva SS, Desai NR, Spatz ES, and Faridi KF
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- 2025
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45. Effects of state opioid prescribing laws on rates of fatal crashes in the USA.
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White SA, McGinty EE, Origenes AN, and Vernick JS
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- Humans, United States epidemiology, Drug Prescriptions statistics & numerical data, Opioid-Related Disorders mortality, Drug Overdose mortality, Drug Overdose prevention & control, Practice Patterns, Physicians' statistics & numerical data, Practice Patterns, Physicians' legislation & jurisprudence, State Government, Prescription Drug Monitoring Programs legislation & jurisprudence, Analgesics, Opioid therapeutic use, Accidents, Traffic mortality, Accidents, Traffic statistics & numerical data, Accidents, Traffic prevention & control
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Background: State opioid prescribing cap laws, mandatory prescription drug monitoring programme query or enrolment laws and pill mill laws have been implemented across US states to curb high-risk opioid prescribing. Previous studies have measured the impact of these laws on opioid use and overdose death, but no prior work has measured the impact of these laws on fatal crashes in a multistate analysis., Methods: To study the association between state opioid prescribing laws and fatal crashes, 13 treatment states that implemented a single law of interest in a 4-year period were identified, together with unique groups of control states for each treatment state. Augmented synthetic control analyses were used to estimate the association between each state law and the overall rate of fatal crashes, and the rate of opioid-involved fatal crashes, per 100 000 licensed drivers in the state. Fatal crash data came from the Fatality Analysis Reporting System., Results: Results of augmented synthetic control analyses showed small-in-magnitude, non-statistically significant changes in all fatal crash outcomes attributable to the 13 state opioid prescribing laws. While non-statistically significant, results attributable to the laws varied in either direction-from an increase of 0.14 (95% CI, -0.32 to 0.60) fatal crashes per 100 000 licensed drivers attributable to Ohio's opioid prescribing cap law, to a decrease of 0.30 (95% CI, -1.17 to 0.57) fatal crashes/100 000 licensed drivers attributable to Mississippi's pill mill law., Conclusion: These findings suggest that state-level opioid prescribing laws are insufficient to help address rising rates of fatally injured drivers who test positive for opioids. Other options will be needed to address this continuing injury problem., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.)
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- 2025
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46. Value-Based Pricing and Its Implications for the Newly Announced Medicare Negotiated Price Under the Inflation Reduction Act.
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Li P, Ali MK, Narayan KMV, Umpierrez GE, Fonseca VA, Shi L, and Shao H
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- 2025
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47. Promoting Evidence-Based Tobacco Cessation Treatment in Community Mental Health Clinics: Results of a Pilot Implementation Study: Promouvoir le traitement de sevrage tabagique fondé sur des données probantes dans les cliniques communautaires de santé mentale : résultats d'une étude pilote de mise en œuvre.
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Dickerson F, Fink T, Goldsholl S, Dalcin A, Eidman B, Yuan CT, Gennusa JV 3rd, Cather C, Evins AE, Wang NY, McGinty EM, and Daumit GL
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Objective: Tobacco smoking is the leading cause of preventable death among individuals with serious mental illness (SMI) but few persons with SMI are offered smoking cessation treatment. The purpose of this study was to pilot-test a multicomponent intervention to increase the delivery of evidence-based smoking cessation treatment in community mental health clinics (CMHCs)., Method: This study was carried out at five CMHCs in Maryland involving clinicians who participated in training in smoking cessation. Other implementation activities included the provision of a treatment protocol, coaching, expert consultation, and organizational strategy meetings. The primary outcome was a change in clinicians' knowledge and self-efficacy about smoking cessation. Secondary outcomes included documentation of evidence-based smoking cessation practices including assessment of smoking status and readiness to quit, and provision of smoking cessation treatment over the course of the 12-month intervention period., Results: A total of 91 clinicians participated in the study. Data were available on 6,011 clients. Clinicians' scores on the knowledge and self-efficacy measures increased modestly over the course of the implementation period. Overall, 57% of clients had their smoking status assessed; 81% of current smokers were evaluated about their willingness to quit; 82% of those willing to quit within 90 days received behavioral counseling, and 36% were prescribed or given smoking cessation pharmacotherapy. Clinicians rated the smoking cessation program highly in terms of acceptability, appropriateness, and feasibility., Conclusions: Clinicians at CMHCs were engaged by and participated in training and implementation activities around smoking cessation practices which they then delivered to a substantial portion of clients in their care. The results of this study provide important data for the future planning of testing implementation strategies to scale up tobacco cessation treatment in this population in outpatient mental health settings., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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48. Regional Trends and Spatial Gradients of Total Column Methane over India, China, and USA─Implications for Emissions from Coal Mining and Oil/Gas Exploitation.
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Deepshikha, Chandra N, Höglund-Isaksson L, Patra PK, and Dey S
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- China, India, United States, Environmental Monitoring, Natural Gas, Air Pollutants analysis, Methane analysis, Coal Mining
- Abstract
Observation-based verification of regional/national methane (CH
4 ) emission trends is crucial for transparent monitoring and mitigation strategy planning. Although surface observations track the global and sub-hemispheric emission trends well, their sparse spatial coverage limits our ability to assess regional trends. Dense satellite observations complement surface observations, offering a valuable means to validate emission trends, especially in regions where emissions changes are substantial but debated. The uncertainty surrounding the rate of increase in fugitive coal mine emissions in China and emissions from unconventional oil and natural gas (ONG) exploration in the United States underscores the need for rigorous validation. Here, we examine the time evolution of total column dry-air mole fractions of CH4 (XCH4 ) during 2010-2020 by comparing observations from the GOSAT satellite with simulations from an atmospheric chemistry-transport model (ACTM). This study analyzes emissions and XCH4 trends in global totals and regions of India, China, the USA, and the global tropics. Our results suggest that GAINSv4 emission inventory overestimates the emission increase rate for the unconventional ONG sector of USA by about 3 times, while EDGARv6 inventory overestimates coal mine emissions in China. Emission increases in China and India agree with those estimated by GAINSv4. Analysis of spatially integrated XCH4 statistics (mean, 1-σ standard deviation) reveals a slight systematic underestimation of total emissions in China and bias (in both directions) in different parts of USA. Our results suggest that long-term satellite observations and ACTM simulations can effectively validate emission inventories for CH4 emissions and emission trends regionally.- Published
- 2025
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49. Hepatitis C Treatment in Kentucky Medicaid Recipients with Concurrent Opioid Use Disorder: A Cross-Sectional Study.
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Sugarman OK, Saloner B, Harris SJ, Irvin R, Flanagan V, and Bandara S
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Background: Hepatitis C virus (HCV) infections and injection drug use have concurrently increased in the last decade. Evidence supports simultaneously treating chronic HCV and opioid use disorder (OUD) with medication. Kentucky is a hard-hit state for both conditions that has undertaken policy and practice efforts to increase access to both types of medications., Objective: To examine receipt of direct-acting antivirals (DAAs) for patients living with HCV-OUD and received any vs. no medications for opioid use disorder (MOUD)., Design: We conducted a cross-sectional study using a proprietary dataset from HealthVerity of health claims between 1/1/2020 and 12/31/2021., Patients: Kentucky Medicaid beneficiaries aged ≥ 18 with concurrent chronic HCV-OUD diagnoses., Main Measures: Multivariable logistic regression models were used to calculate adjusted proportions of HCV DAA receipt based on receipt of MOUD, adjusting for patient characteristics and region., Key Results: Of 2149 patients, 36% (n = 780) received HCV DAAs; 84% (n = 1804) received any MOUD during the study period. Buprenorphine was the most common MOUD type used (n = 1414, 66%). Adjusting for covariates, HCV DAA receipt was lower among people who received any vs. no MOUD (33% vs. 46%, p < 0.0001). Methadone (vs. no MOUD, 29% vs. 46%, p = 0.0002) had the greatest difference in odds of HCV DAA receipt., Conclusions: Gaps in HCV treatment among Kentucky Medicaid recipients with OUD were pervasive. Despite evidence supporting HCV-OUD co-treatment, patients receiving MOUD were significantly less likely to receive curative HCV treatment., Competing Interests: Declarations:. Conflict of Interest:: Dr. Sugarman, Dr. Saloner, Dr. Harris, Dr. Bandara, and Ms. Flanagan reported receiving grants from Bloomberg Philanthropies during the conduct of the study. Dr. Bandara reported receiving grants from the National Institutes of Health and Centers for Disease Prevention and Control outside the submitted work. Dr. Irvin reported part-time work on federal detail at the National Institutes of Health on the national hepatitis C elimination plan outside the submitted work. Dr. Saloner reported personal fees from Susman Godfrey outside the submitted work., (© 2025. The Author(s), under exclusive licence to Society of General Internal Medicine.)
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- 2025
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50. Reimagining Care and Research for Amyotrophic Lateral Sclerosis.
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Babu S, Sharfstein JM, and Feldman EL
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- 2025
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