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The present study examines the key factors determining the quality of sound design in the post-production stage, the importance of which is often overlooked in Turkish film and television. To this end, we evaluate the technical infrastructure used by the industry, the quantitative aspects and competencies of professionals, as well as their needs and the problems they encounter. The "snowball sampling" technique was used to reach out to prominent professionals with whom in-depth interviews were conducted. The data obtained during the interviews were subjected to descriptive analysis, based on which the strengths and weaknesses of Turkish TV and cinema were examined. Although employees in the Turkish sector are no different from their peers in other countries in terms of their qualifications and technical abilities, the study reveals that the time and budget allocated to the visual aspects of film production in Türkiye are considerably above those allocated to sound design, and that responsibility for this matter lies with the director and producer. This study is important in terms of presenting findings about the sectoral situation of the sound design to the academic literature. [ABSTRACT FROM AUTHOR]

Working in a hospital is a very stressful and sometimes risky process for all healthcare professionals who have experienced this difficult process for years. This situation may increase the suicidal tendency of healthcare workers as a result of not only physical but also psychological exhaustion. The purpose of this study was to determine the examination of suicidal ideation and related factors among healthcare professionals working in a research and practice hospital. The data of this descriptive and cross-sectional study were collected prospectively by clinicians in a research and practice hospital. The sample of the research consisted of n=600 healthcare workers. The average age of healthcare workers was 32.46±7.79 years; 48% were women and 47.7% were married. 4% of healthcare workers had a past suicide attempt, and 18% had various levels of suicidal ideation. Women were more likely to attempt suicide. There was a positive, strong, and statistically significant correlation between depression, anxiety severity and suicidal ideation. Suicidal thoughts of healthcare professionals are affected by gender, depression and anxiety. The mental health of healthcare professionals should be evaluated periodically, and psychological support should be provided to healthcare professionals at risk of suicide. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is one of the most widespread neurological disorders associated with nerve damage without definitive treatment. Impairments, such as trembling and slowing down in hand movements are among the first symptoms. For this purpose, in this study, machine learning (ML)-based models were developed by using keyboard keystroke dynamics. According to patients' drug use status, disease severity, and gender, we created 14 different sub-datasets and extracted 378 features using raw keystroke data. We developed alternative models with Support Vector Machines (SVM), k-Nearest Neighbors (kNN), and Random Forest (RF) algorithms. We further used Minimum Redundancy Maximum Relevance (mRmR), RELIEF, sequential forward selection (SFS), and RF feature selection methods to investigate prominent features in distinguishing PD. We developed ML models that jointly use the most popular features of selection algorithms (feature ensemble [FE]) and an ensemble classifier by combining multiple ML algorithms utilizing majority vote (model ensemble [ME]). With 14 different sets, FE and ME models provided accuracy (Acc.) in the range of 91.73 − 100% and 81.08 − 100%, respectively. [ABSTRACT FROM AUTHOR]

Among the thermoplastic elastomers that play important roles in the polymer industry due to their superior properties, styrene‐based species and polyurethane block copolymers are of great interest. Poly(styrene‐ethylene‐butadiene‐styrene) (SEBS) as a triblock copolymer seems to have the potential to meet many demands in different applications due to various industrial requirements where durability, biocompatibility, breaking elongation, and interfacial adhesion are important. In this study, the SEBS triblock copolymer was functionalized with natural (Satureja hortensis, SH) and synthetic (nanopowder, TiO2) agents to obtain composite nanofibers by electrospinning and electrospraying methods for use in biomedical and water filtration applications. The results were compared with thermoplastic polyurethane (TPU) composite nanofibers, which are commonly used in these fields. Here, functionalized SEBS nanofibers exhibited antibacterial effect while at the same time improving cell viability. In addition, because of successful water filtration by using the SEBS composite nanofibers, the material may have a good potential to be used comparably to TPU for the application. [ABSTRACT FROM AUTHOR]

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Purpose: This study aims to evaluate the real-world efficacy and safety profile of fluocinolone acetonide (FAc) implants for the treatment of non-infectious uveitis (NIU)., Methods: A retrospective, observational study was conducted at Moorfields Eye Hospital, London, involving patients who received FAc 0.19 mg implants (Iluvien®) for NIU. 2-year follow-up data on baseline characteristics, indications, and outcomes was collected. The primary indicator for treatment failure was defined as the need for rescue treatment with dexamethasone (DEX) implants, while secondary indicators included changes in steroid and systemic immunosuppression requirements, or the need for a second FAc implant before 3 years. The occurrence of complications was collected., Results: Of the 146 eyes treated with FAc implants, 24.0% experienced treatment failure requiring DEX implant within 2 years. About 42.9% required this within the first 6 months. There was an increase in the number of patients requiring steroids and/or systemic immunosuppression. Within the first 2 years post-FAc implant, only 13.7% experienced an IOP rise, with 4.1% requiring IOP-lowering surgery. About 57.9% of the phakic eyes developed cataracts., Conclusion: This study provides valuable real-world evidence supporting the efficacy of FAc implant in NIU. It demonstrates a good safety profile at 2 years, with a significant reduction in uveitis recurrence rate and treatment burden. Our results are especially pertinent to the treatment of uveitic cystoid macular oedema (CMO), which was the primary indication in over 75% of our patients. Furthermore, it suggests that while FAc implant controls retinal inflammation effectively, choroidal inflammation would require alternative treatment.

Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological aspects along with high effectiveness, new thiazole derivatives have been studied by medicinal chemists since many years., Objective: Some thiazole compounds combined with different heterocyclic rings were acquired in this study. Novel 5-(4-substituted benzylidene)-2-[(4,5-dimethylthiazol-2-yl)amino]thiazol-4(5H)-one derivatives (4a-g) and 2-(heteroaryl-2/3/5-yl)thio-N-(4,5-dimethylthiazol-2-yl)acetamide (4h-p) derivatives were synthesized starting from 2-amino-4,5-dimethylthiazole. The obtained compounds were evaluated to determine their antiproliferative activity., Method: Final compounds (4a-g) were obtained with a ring closure reaction; other final compounds (4h-p) were acquired via the reaction of mercapto heterocycles with Hantzsch thiazole synthesis intermediate. To evaluate antiproliferative activity of them, the compounds were tested on A549 adenocarcinomic human alveolar basal epithelial cells line, C6 rat glioma cell line and NIH/3T3 mouse embryo fibroblast cell line according to the conventional MTT method. Besides, the selected compounds were studied to find out which pathway cell deaths caused via Annexin V/PI staining., Results: Compounds 4f, 4j and 4p exhibited the highest cytotoxicity on A549 with a non-toxic profile. Also, 4f, 4h, 4j and 4p were determined as the most antiproliferative compounds on C6 cell line. Furthermore, compound 4p induced apoptosis of A549 cell with a level of 23.5% and compound 4h induced C6 cell with a level of 37.5%., Conclusion: Considering the structure of the compounds, although thiazolidine containing compounds 4a-g exhibited higher activity in general, compounds 4p containing 5-chlorobenzothiazole moiety showed the highest cytotoxicity. It could be expressed with the conspicuous antitumor efficiency of benzothiazole ring., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents., Objective: In this study, we have designed and synthesized novel 2-[(5,6-diphenyl-1,2,4-triazin-3-yl)thio]-N-(6- substituted benzo/(thiazol)-2-yl)acetamide (2a-d, 3a-f) derivatives using 1,2,4-triazine core along with two important heterocyles, thiazole and benzothiazole rings., Method: The acquired ten final compounds were screened to investigate their antitumor activity against lung adenocarcinoma cell line, A549 and mouse fibroblast cell line, NIH/3T3. Five compounds with higher antiproliferative activity have been further studied to evaluate whether the cell death due to necrosis or apoptosis using flow cytometry., Results and Conclusion: Compound 3b bearing 6-methylbenzothiazole moiety has been established as the most active antitumor compound with a selective profile and higher apoptotic cell level. All final componds were also screened against acetylcholine/butyrylcholinesterase enzymes to state their anticholinesterase activity., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)