Search

Your search keyword '"Degos, Laurent"' showing total 209 results
Start Over Author "Degos, Laurent" Language english
209 results on '"Degos, Laurent"'

7. Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience

Author

Adès, Lionel, Guerci, Agnes, Raffoux, Emmanuel, Sanz, Miguel, Chevallier, Patrice, Lapusan, Simona, Recher, Christian, Thomas, Xavier, Rayon, Consuelo, Castaigne, Sylvie, Tournilhac, Olivier, de Botton, Stephane, Ifrah, Norbert, Cahn, Jean-Yves, Solary, Eric, Gardin, Claude, Fegeux, Nathalie, Bordessoule, Dominique, Ferrant, Augustin, Meyer-Monard, Sandrine, Vey, Norbert, Dombret, Herve, Degos, Laurent, Chevret, Sylvie, Fenaux, Pierre, and for the European APL Group

Published
2010
Full Text
View/download PDF

8. Evolving Characteristics and Outcome of Secondary Acute Promyelocytic Leukemia (APL): A Prospective Analysis by the French-Belgian-Swiss APL Group

Author

Braun, Thorsten, Cereja, Sophie, Chevret, Sylvie, Raffoux, Emmanuel, Beaumont, Marie, Detourmignies, Laurence, Pigneux, Arnaud, Thomas, Xavier, Bordessoule, Dominique, Guerci, Agnès, Lamy, Thierry, Recher, Christian, Poiré, Xavier, Tournilhac, Olivier, Spertini, Olivier, Chomienne, Christine, Degos, Laurent, Dombret, Hervé, Adès, Lionel, and Fenaux, Pierre

Published
2015
Full Text
View/download PDF

12. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results

Author

Adès, Lionel, Sanz, Miguel A., Chevret, Sylvie, Montesinos, Pau, Chevallier, Patrice, Raffoux, Emmanuel, Vellenga, Edo, Guerci, Agnès, Pigneux, Arnaud, Huguet, Francoise, Rayon, Consuelo, Stoppa, Anne Marie, de la Serna, Javier, Cahn, Jean-Yves, Meyer-Monard, Sandrine, Pabst, Thomas, Thomas, Xavier, de Botton, Stéphane, Parody, Ricardo, Bergua, Juan, Lamy, Thierry, Vekhoff, Anne, Negri, Silvia, Ifrah, Norbert, Dombret, Hervé, Ferrant, Augustin, Bron, Dominique, Degos, Laurent, and Fenaux, Pierre

Published
2008
Full Text
View/download PDF

13. Long-term follow-up of European APL 2000 trial, evaluating the role of cytarabine combined with ATRA and Daunorubicin in the treatment of nonelderly APL patients

Author

Adès, Lionel, Chevret, Sylvie, Raffoux, Emmanuel, Guerci-Bresler, Agnes, Pigneux, Arnaud, Vey, Nobert, Lamy, Thierry, Huguet, Francoise, Vekhoff, Anne, Lambert, Jean-Francois, Lioure, Bruno, de Botton, Stephane, Deconinck, Erick, Ferrant, Augustin, Thomas, Xavier, Quesnel, Bruno, Cassinat, Bruno, Chomienne, Christine, Dombret, Hervé, Degos, Laurent, and Fenaux, Pierre

Published
2013
Full Text
View/download PDF

14. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia

Author

Padua, Rose Ann, Larghero, Jerome, Robin, Marie, Pogam, Carol le, Schlageter, Marie-Helene, Muszlak, Sacha, Fric, Jan, West, Robert, Rousselot, Philippe, Phan, Thi Hai, Mudde, Liesbeth, Teisserenc, Helene, Carpentier, Antoine F, Kogan, Scott, Degos, Laurent, Pla, Marika, Bishop, J Michael, Stevenson, Freda, Charron, Dominique, and Chomienne, Christine

Abstract

Author(s): Rose Ann Padua (corresponding author) [1, 2]; Jerome Larghero [1]; Marie Robin [1]; Carol le Pogam [1]; Marie-Helene Schlageter [1]; Sacha Muszlak [2]; Jan Fric [1]; Robert West [3]; [...]

Published
2003
Full Text
View/download PDF

17. Foreword

Author

Godlee, Fiona, Cabarrot, Philippe, Desplanques, Armelle, Smith, Jane, and Degos, Laurent

Published
2010
Full Text
View/download PDF

21. Is Cytarabine Useful in the Treatment of Acute Promyelocytic Leukemia? Results of a Randomized Trial From the European Acute Promyelocytic Leukemia Group

Author

Adès, Lionel, Chevret, Sylvie, Raffoux, Emmanuel, de Botton, Stephane, Guerci, Agnes, Pigneux, Arnaud, Stoppa, Anne Marie, Lamy, Thierry, Rigal-Huguet, Francoise, Vekhoff, Anne, Meyer-Monard, Sandrine, Maloisel, Frederic, Deconinck, Eric, Ferrant, Augustin, Thomas, Xavier, Fegueux, Nathalie, Chomienne, Christine, Dombret, Herve, Degos, Laurent, and Fenaux, Pierre

Published
2006
Full Text
View/download PDF

22. Randomized comparison of double induction and timed-sequential induction to a “3 + 7” induction in adults with AML: long-term analysis of the Acute Leukemia French Association (ALFA) 9000 study

Author

Castaigne, Sylvie, Chevret, Sylvie, Archimbaud, Eric, Fenaux, Pierre, Bordessoule, Dominique, Tilly, Hervé, de Revel, Thierry, Simon, Marc, Dupriez, Brigitte, Renoux, Michel, Janvier, Maud, Micléa, Jean-Michel, Thomas, Xavier, Bastard, Christian, Preudhomme, Claude, Bauters, Francis, Degos, Laurent, and Dombret, Hervé

Published
2004
Full Text
View/download PDF

24. Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec®) in vitro and in vivo

Author

Larghero, Jérôme, Leguay, Thibaut, Mourah, Samia, Madelaine-Chambrin, Isabelle, Taksin, Anne-Laure, Raffoux, Emmanuel, Bastie, Jean-Noel, Degos, Laurent, Berthaud, Patrice, Marolleau, Jean-Pierre, Calvo, Fabien, Chomienne, Christine, Mahon, François-Xavier, and Rousselot, Philippe

Published
2003
Full Text
View/download PDF

28. Additional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trial

Author

de Botton, Stéphane, Chevret, Sylvie, Sanz, Miguel, Dombret, Hervé, Thomas, Xavier, Guerci, Agnès, Fey, Martin, Rayon, Consuelo, Huguet, Françoise, Sotto, Jean-Jacques, Gardin, Claude, Cony Makhoul, Pascale, Travade, Philippe, Solary, Eric, Fegueux, Nathalie, Bordessoule, Dominique, San Miguel, Jesus, Link, Harmut, Desablens, Bernard, Stamatoullas, Aspasia, Deconinck, Eric, Geiser, K, Hess, U, Maloisel, Fréderic, Castaigne, Sylvie, Preudhomme, Claude, Chomienne, Christine, Degos, Laurent, and Fenaux, Pierre

Published
2000

32. Suitability of three indicators measuring the quality of coordination within hospitals

Author

Loirat Philippe, Grenier Catherine, Capuano Frédéric, Leleu Henri, Minvielle Etienne, and Degos Laurent

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Coordination within hospitals is a major attribute of medical care and influences quality of care. This study tested the validity of 3 indicators covering two key aspects of coordination: the transfer of written information between professionals (medical record content, radiology exam order) and the holding of multidisciplinary team meetings during treatment planning. Methods The study was supervised by the French health authorities (COMPAQH project). Data for the three indicators were collected in a panel of 30 to 60 volunteer hospitals by 6 Clinical Research Assistants. The metrological qualities of the indicators were assessed: (i) Feasibility was assessed using a grid of 19 potential problems, (ii) Inter-observer reliability was given by the kappa coefficient () and internal consistency by Cronbach's alpha test, (iii) Discriminatory power was given by an analysis of inter-hospital variability using the Gini coefficient as a measure of dispersion. Results Overall, 19281 data items were collected and analyzed. All three indicators presented acceptable feasibility and reliability (, 0.59 to 0.97) and showed wide differences among hospitals (Gini, 0.08 to 0.11), indicating that they are suitable for making comparisons among hospitals. Conclusion This set of 3 indicators provides a proxy measurement of coordination. Further research on the indicators is needed to find out how they can generate a learning process. The medical record indicator has been included in the French national accreditation procedure for healthcare organisations. The two other indicators are currently being assessed for inclusion.

Published
2010
Full Text
View/download PDF

37. Acute Promyelocytic Leukemia

Author

Stadler, Michael, Ganser, Arnold, Hoelzer, Dieter, Izumi, Tohru, Hatake, Kiyohiko, Miura, Yasusada, Warrell, Raymond P., and Degos, Laurent.

Published
1994
Full Text
View/download PDF

43. Dose effect of cis- and trans-encoded HLA-DQ-alpha-beta heterodimers in IDDM susceptibility

Author

Khalil, Iman, Deschamps, Ingeborg, Lepage, Virginia, Al-Daccak, Reem, Degos, Laurent, and Hors, Jacques

Subjects
Type 1 diabetes -- Genetic aspects, Disease susceptibility -- Genetic aspects, Health, Genetic aspects
Abstract

Insulin-dependent diabetes mellitus (IDDM) in whites is strongly associated with particular HLA-DQ [Alpha] Β heterodimers composed of a DQ [Alpha] chain with an arginine at residue 52 ([Arg52.sup.+]) combined to a DQ Β chain lacking an aspartic acid at residue 57 ([Asp57.sup.-]). With the aim of confirming this association, clarifying which heterodimers account for the risk of IDDM and explaining the excess risk of DR3-DQw2/DR4-DQw8, 115 unrelated white IDDM patients and 108 unrelated healthy nondiabetic control subjects were studied. With polymerase chain reaction and sequence-specific oligonucleotide probes, both patients and control subjects were typed for their HLA-DQA1 and DQB1 alleles and their DQA1-DQB1 haplotype and genotype frequencies were compared. Four major findings emerged from our analysis. 1) [Arg52.sup.+] DQ [Alpha]/[Asp57.sup.-] DQ Β heterodimers, formed in cis and/or in trans, are strongly associated with susceptibility to IDDM; 97% of patients and 46% of control subjects had at least one such susceptibility heterodimers (relative risk [RR] 32, confidence interval [CI] 14.25-71.86, P < [10.sup.-7]). 2) The degree of disease susceptibility depends on the number of such DQ heterodimers that a subject can express according to his or her DQA1-DQB1 genotype. The highest RR was observed in patients with four susceptibility DQ heterodimers (RR 41, CI 17.05-95.5). 3) Only part of the susceptibility DQ heterodimers were significantly increased in patients, conferring IDDM susceptibility of different strength. The strongest association was with the DQA1*0501-DQB1*0302 combination formed in trans position (RR 35.2, CI 12.88-96.78, P < [10.sup.-7]). 4) The stimulation expression of four different susceptibility heterodimers explains the highest risk of DR3-DQw2/DR4-DQw8 heterozygotes. In conclusion, there is a dose effect of cis- and trans-encoded HLA-DQ [Alpha] Β heterodimers in IDDM susceptibility influenced by the diversity of these molecules. Diabetes 41:378-84, 1992, Insulin-dependent diabetes mellitus (IDDM) results from autoimmune destruction of the insulin-producing Β cells of pancreatic islets. Genetic predisposition to IDDM is partly determined by genes encoded within the MHC, located [...]

Published
1992

44. A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

Author

Fenaux, Pierre, Chastang, Claude, Chevret, Sylvie, Sanz, Miguel, Dombret, Hervé, Archimbaud, Eric, Fey, Martin, Rayon, Consuelo, Huguet, Françoise, Sotto, Jean-Jacques, Gardin, Claude, Makhoul, Pascale Cony, Travade, Philippe, Solary, Eric, Fegueux, Nathalie, Bordessoule, Dominique, Miguel, Jesus San, Link, Harmut, Desablens, Bernard, Stamatoullas, Aspasia, Deconinck, E., Maloisel, Fréderic, Castaigne, Sylvie, Preudhomme, Claude, and Degos, Laurent

Published
1999
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results