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2. EuPRAXIA Conceptual Design Report

Author

Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Bründermann, E., Büscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chancé, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D’Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. M., Di Giovenale, D., Diomede, M., Di Pasquale, E., Di Pirro, G., Di Raddo, G., Dorda, U., Erlandson, A. C., Ertel, K., Esposito, A., Falcoz, F., Falone, A., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fils, J., Fiore, G., Fiorito, R., Fonseca, R. A., Franzini, G., Galimberti, M., Gallo, A., Galvin, T. C., Ghaith, A., Ghigo, A., Giove, D., Giribono, A., Gizzi, L. A., Grüner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Helm, A., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Hübner, M., Ibison, M., Incremona, S., Irman, A., Iungo, F., Jafarinia, F. J., Jakobsson, O., Jaroszynski, D. A., Jaster-Merz, S., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Kirchen, M., Kirwan, G., Kitégi, C., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Le Blanc, C., Lechner, C., Lee, P., Leemans, W., Lehrach, A., Li, X., Li, Y., Libov, V., Lifschitz, A., Lindstrøm, C. A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marcelli, A., Marchetti, B., Marcouillé, O., Marocchino, A., Marteau, F., Martinez de la Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Mironov, S., Molodozhentsev, A. Y., Morante, S., Mosnier, A., Mostacci, A., Müller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Nutter, A., Osterhoff, J., Oumbarek Espinos, D., Paillard, J. -L., Papadopoulos, D. N., Patrizi, B., Pattathil, R., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Reagan, B. A., Resta-Lopez, J., Ricci, R., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Rotundo, U., Roussel, E., Sabbatini, L., Santangelo, P., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sharma, G., Sheng, Z. M., Shpakov, V., Siders, C. W., Silva, L. O., Silva, T., Simon, C., Simon-Boisson, C., Sinha, U., Sistrunk, E., Specka, A., Spinka, T. M., Stecchi, A., Stella, A., Stellato, F., Streeter, M. J. V., Sutherland, A., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Valléau, M., Vannini, M., Vannozzi, A., Vescovi, S., Vieira, J. M., Villa, F., Wahlström, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, A., Welsch, C. P., Weng, S. M., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhang, H., Zhao, Y., Zhu, J., and Zigler, A.

Published
2020
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3. Erratum to: EuPRAXIA Conceptual Design Report: Eur. Phys. J. Special Topics 229, 3675-4284 (2020), https://doi.org/10.1140/epjst/e2020-000127-8

Author

Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Bründermann, E., Büscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chancé, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D’Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. M., Di Giovenale, D., Diomede, M., Di Pasquale, E., Di Pirro, G., Di Raddo, G., Dorda, U., Erlandson, A. C., Ertel, K., Esposito, A., Falcoz, F., Falone, A., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fils, J., Fiore, G., Fiorito, R., Fonseca, R. A., Franzini, G., Galimberti, M., Gallo, A., Galvin, T. C., Ghaith, A., Ghigo, A., Giove, D., Giribono, A., Gizzi, L. A., Grüner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Helm, A., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Hübner, M., Ibison, M., Incremona, S., Irman, A., Iungo, F., Jafarinia, F. J., Jakobsson, O., Jaroszynski, D. A., Jaster-Merz, S., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Kirchen, M., Kirwan, G., Kitégi, C., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Le Blanc, C., Lechner, C., Lee, P., Leemans, W., Lehrach, A., Li, X., Li, Y., Libov, V., Lifschitz, A., Lindstrøm, C. A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marcelli, A., Marchetti, B., Marcouillé, O., Marocchino, A., Marteau, F., Martinez de la Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Mironov, S., Molodozhentsev, A. Y., Morante, S., Mosnier, A., Mostacci, A., Müller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Nutter, A., Osterhoff, J., Oumbarek Espinos, D., Paillard, J. -L., Papadopoulos, D. N., Patrizi, B., Pattathil, R., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Reagan, B. A., Resta-Lopez, J., Ricci, R., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Rotundo, U., Roussel, E., Sabbatini, L., Santangelo, P., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sharma, G., Sheng, Z. M., Shpakov, V., Siders, C. W., Silva, L. O., Silva, T., Simon, C., Simon-Boisson, C., Sinha, U., Sistrunk, E., Specka, A., Spinka, T. M., Stecchi, A., Stella, A., Stellato, F., Streeter, M. J. V., Sutherland, A., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Valléau, M., Vannini, M., Vannozzi, A., Vescovi, S., Vieira, J. M., Villa, F., Wahlström, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, A., Welsch, C. P., Weng, S. M., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhang, H., Zhao, Y., Zhu, J., and Zigler, A.

Published
2020
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9. Euclid preparation : XX. The Complete Calibration of the Color-Redshift Relation survey: LBT observations and data release

Author

Euclid Collaboration, Saglia, R., De Nicola, S., Fabricius, M., Guglielmo, V., Snigula, J., Zöller, R., Bender, R., Heidt, J., Masters, D., Stern, D., Paltani, S., Amara, A., Auricchio, N., Baldi, M., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hoekstra, H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., Kümmel, M., Kermiche, S., Kiessling, A., Kunz, M., Kurki-Suonio, H., Laureijs, R., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Marggraf, O., Markovic, K., Marulli, F., Massey, R., McCracken, H. J., Melchior, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Poncet, M., Popa, L., Pozzetti, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Rossetti, E., Sapone, D., Sartoris, B., Schneider, P., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Tallada-Crespí, P., Tavagnacco, D., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Andreon, S., Bardelli, S., Graciá-Carpio, J., Maino, D., Mauri, N., Tramacere, A., Zucca, E., Ayllon, A. Alvarez, Aussel, H., Baccigalupi, C., Balaguera-Antolínez, A., Ballardini, M., Biviano, A., Bolzonella, M., Bozzo, E., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Davini, S., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Farina, M., Fotopoulou, S., Ganga, K., Garcia-Bellido, J., George, K., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Hook, I., Ilbert, O., Kansal, V., Kashlinsky, A., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Macías-Pérez, J., Magliocchetti, M., Mainetti, G., Maoli, R., Martinelli, M., Martinet, N., Metcalf, R. B., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Popa, V., Porciani, C., Potter, D., Pourtsidou, A., Reimberg, P., Sánchez, A. G., Sakr, Z., Schirmer, M., Sefusatti, E., Sereno, M., Stadel, J., Teyssier, R., Valieri, C., Valiviita, J., Veropalumbo, A., Viel, M., Department of Physics, Research Program in Systems Oncology, Helsinki Institute of Physics, Saglia, R., De Nicola, S., Fabricius, M., Guglielmo, V., Snigula, J., Z??ller, R., Bender, R., Heidt, J., Masters, D., Stern, D., Paltani, S., Amara, A., Auricchio, N., Baldi, M., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hoekstra, H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., K??mmel, M., Kermiche, S., Kiessling, A., Kunz, M., Kurki-Suonio, H., Laureijs, R., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Marggraf, O., Markovic, K., Marulli, F., Massey, R., Mccracken, H. J., Melchior, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Poncet, M., Popa, L., Pozzetti, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Rossetti, E., Sapone, D., Sartoris, B., Schneider, P., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Tallada-Cresp??, P., Tavagnacco, D., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Andreon, S., Bardelli, S., Graci??-Carpio, J., Maino, D., Mauri, N., Tramacere, A., Zucca, E., Alvarez Ayllon, A., Aussel, H., Baccigalupi, C., Balaguera-Antol??nez, A., Ballardini, M., Biviano, A., Bolzonella, M., Bozzo, E., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Davini, S., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Farina, M., Fotopoulou, S., Ganga, K., Garcia-Bellido, J., George, K., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Hook, I., Ilbert, O., Kansal, V., Kashlinsky, A., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Mac??as-P??rez, J., Magliocchetti, M., Mainetti, G., Maoli, R., Martinelli, M., Martinet, N., Metcalf, R. B., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Popa, V., Porciani, C., Potter, D., Pourtsidou, A., Reimberg, P., S??nchez, A. G., Sakr, Z., Schirmer, M., Sefusatti, E., Sereno, M., Stadel, J., Teyssier, R., Valieri, C., Valiviita, J., Veropalumbo, A., Viel, M., Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Euclid, Intelligent Systems, Astronomy, R. Saglia, S. De Nicola, M. Fabriciu, V. Guglielmo, J. Snigula, R. Zöller, R. Bender, J. Heidt, D. Master, D. Stern, S. Paltani, A. Amara, N. Auricchio, M. Baldi, C. Bodendorf, D. Bonino, E. Branchini, M. Brescia, J. Brinchmann, S. Camera, V. Capobianco, C. Carbone, J. Carretero, M. Castellano, S. Cavuoti, R. Cledassou, G. Congedo, C. J. Conselice, L. Conversi, Y. Copin, L. Corcione, F. Courbin, M. Cropper, A. Da Silva, H. Degaudenzi, M. Douspi, F. Dubath, C. A. J. Duncan, X. Dupac, S. Dusini, S. Farren, M. Fraili, E. Franceschi, S. Galeotta, B. Garilli, W. Gillard, B. Gilli, C. Giocoli, A. Grazian, F. Grupp, S. V. H. Haugan, H. Hoekstra, W. Holme, F. Hormuth, A. Hornstrup, K. Jahnke, M. Kümmel, S. Kermiche, A. Kiessling, M. Kunz, H. Kurki-Suonio, R. Laureij, S. Ligori, P. B. Lilje, I. Lloro, E. Maiorano, O. Marggraf, K. Markovic, F. Marulli, R. Massey, H. J. McCracken, M. Melchior, G. Meylan, M. Moresco, L. Moscardini, E. Munari, S. M. Niemi, C. Padilla, F. Pasian, K. Pedersen, W. J. Percival, V. Pettorino, S. Pire, M. Poncet, L. Popa, L. Pozzetti, F. Raison, A. Renzi, J. Rhode, G. Riccio, E. Romelli, E. Rossetti, D. Sapone, B. Sartori, P. Schneider, A. Secroun, G. Seidel, C. Sirignano, G. Sirri, L. Stanco, P. Tallada-Crespí, D. Tavagnacco, A. N. Taylor, I. Tereno, R. Toledo-Moreo, F. Torradeflot, I. Tutusau, E. A. Valentijn, L. Valenziano, T. Vassallo, Y. Wang, A. Zacchei, G. Zamorani, J. Zoubian, S. Andreon, S. Bardelli, J. Graciá-Carpio, D. Maino, N. Mauri, A. Tramacere, E. Zucca, A. Alvarez Ayllon, H. Aussel, C. Baccigalupi, A. Balaguera-Antolínez, M. Ballardini, A. Biviano, M. Bolzonella, E. Bozzo, C. Burigana, R. Cabanac, A. Cappi, C. S. Carvalho, S. Casa, G. Castignani, A. Cooray, J. Coupon, H. M. Courtoi, S. Davini, G. Desprez, H. Dole, J. A. Escartin, S. Escoffier, M. Farina, S. Fotopoulou, K. Ganga, J. Garcia-Bellido, K. George, F. Giacomini, G. Gozaliasl, H. Hildebrandt, I. Hook, O. Ilbert, V. Kansal, A. Kashlinsky, E. Keihanen, C. C. Kirkpatrick, A. Loureiro, J. Macías-Pérez, M. Magliocchetti, G. Mainetti, R. Maoli, M. Martinelli, N. Martinet, R. B. Metcalf, G. Morgante, S. Nadathur, A. A. Nucita, L. Patrizii, V. Popa, C. Porciani, D. Potter, A. Pourtsidou, P. Reimberg, A. G. Sánchez, Z. Sakr, M. Schirmer, E. Sefusatti, M. Sereno, J. Stadel, R. Teyssier, C. Valieri, J. Valiviita, A. Veropalumbo, M. Viel, Zöller, R., Kümmel, M., Tallada-Crespí, P., Graciá-Carpio, J., Balaguera-Antolínez, A., Macías-Pérez, J., and Sánchez, A. G.

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), catalogs, Galaxies: distances and redshifts, surveys, Astrophysics - cosmology and nongalactic astrophysics, Astrophysics::Instrumentation and Methods for Astrophysics, Euclid, FOS: Physical sciences, Galaxies - distances and redshifts, Astronomy and Astrophysics, cosmos, Astrophysics::Cosmology and Extragalactic Astrophysics, Surveys, 115 Astronomy, Space science, Cosmology, deep imaging survey, Space and Planetary Science, distances and redshifts, catalogs, surveys [galaxies], distances and redshifts [Galaxies], galaxies: distances and redshifts, Catalogs, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics::Galaxy Astrophysics
Abstract

The Complete Calibration of the Color-Redshift Relation survey (C3R2) is a spectroscopic programme designed to empirically calibrate the galaxy color-redshift relation to the Euclid depth (I_E=24.5), a key ingredient for the success of Stage IV dark energy projects based on weak lensing cosmology. A spectroscopic calibration sample as representative as possible of the galaxies in the Euclid weak lensing sample is being collected, selecting galaxies from a self-organizing map (SOM) representation of the galaxy color space. Here, we present the results of a near-infrared H- and K-bands spectroscopic campaign carried out using the LUCI instruments at the LBT. For a total of 251 galaxies, we present new highly-reliable redshifts in the 1.3, A&A language edited version

Published
2022
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12. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

14. Accuracy and precision of triaxial orbit models I: SMBH mass, stellar mass, and dark-matter halo.

Author

Neureiter, B, de Nicola, S, Thomas, J, Saglia, R, Bender, R, and Rantala, A

Subjects
*STELLAR mass, *ORBITS (Astronomy), *GALAXY mergers, *SUPERMASSIVE black holes, *BLACK holes, *MECHANICAL models
Abstract

We investigate the accuracy and precision of triaxial dynamical orbit models by fitting 2D mock observations of a realistic N -body merger simulation resembling a massive early-type galaxy with a supermassive black hole. We show that we can reproduce the triaxial N -body merger remnant's correct black hole mass, stellar mass-to-light ratio and total enclosed mass (inside the half-light radius) for several different tested orientations with an unprecedented accuracy of 5–10 per cent. Our dynamical models use the entire non-parametric line-of-sight velocity distribution (LOSVD) rather than parametric LOSVDs or velocity moments as constraints. Our results strongly suggest that state-of-the-art integral-field projected kinematic data contain only minor degeneracies with respect to the mass and anisotropy recovery. Moreover, this also demonstrates the strength of the Schwarzschild method in general. We achieve the proven high recovery accuracy and precision with our newly developed modelling machinery by combining several advancements: (i) our new semiparametric deprojection code probes degeneracies and allows us to constrain the viewing angles of a triaxial galaxy; (ii) our new orbit modelling code SMART uses a 5-dim orbital starting space to representatively sample in particular near-Keplerian orbits in galaxy centres; (iii) we use a generalized information criterion AICp to optimize the smoothing and to compare different mass models to avoid biases that occur in χ2-based models with varying model flexibilities. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Status of the Horizon 2020 EuPRAXIA conceptual design study

Author

Weikum, MK, Akhter, T, Alesini, D, Alexandrova, AS, Anania, MP, Andreev, NE, Andriyash, IA, Aschikhin, A, Assmann, RW, Audet, T, Bacci, A, Barna, IF, Beaton, A, Beck, A, Beluze, A, Bernhard, A, Bielawski, S, Bisesto, FG, Brandi, F, Brinkmann, R, Bruendermann, E, Buescher, M, Bussmann, MH, Bussolino, G, Chance, A, Chen, M, Chiadroni, E, Cianchi, A, Clarke, JA, Cole, J, Couprie, ME, Croia, M, Cros, B, Crump, PA, Dattoli, G, Del Dotto, A, Delerue, N, De Nicola, S, Dias, JM, Dorda, U, Fedele, R, Pousa, A Ferran, Ferrario, M, Filippi, F, Fiore, G, Fonseca, RA, Galimberti, M, Gallo, A, Ghaith, A, Giove, D, Giribono, A, Gizzi, LA, Gruener, FJ, Habib, AF, Haefner, C, Heinemann, T, Hidding, B, Holzer, BJ, Hooker, SM, Hosokai, T, Huebner, M, Irman, A, Jafarinia, FJ, Jaroszynski, DA, Joshi, C, Kaluza, M, Kando, M, Karger, OS, Karsch, S, Khazanov, E, Khikhlukha, D, Knetsch, A, Kocon, D, Koester, P, Kononenko, OS, Korn, G, Kostyukov, I, Kruchinin, KO, Labate, L, Le Blanc, C, Lechner, C, Leemans, W, Lehrach, A, Li, X, Libov, V, Lifschitz, A, Litvinenko, V, Lu, W, Lundh, O, Maier, AR, Malka, V, Manahan, GG, Mangles, SPD, Marchetti, B, de la Ossa, A Martinez, Martins, JL, Mason, PD, Massimo, F, Mathieu, F, Maynard, G, Mazzotta, Z, Molodozhentsev, AY, Mostacci, A, Mueller, A-S, Murphy, CD, Najmudin, Z, Nghiem, PAP, Nguyen, F, Niknejadi, P, Osterhoff, J, Espinos, D Oumbarek, Papadopoulos, DN, Patrizi, B, Petrillo, V, Pocsai, MA, Poder, K, Pompili, R, Pribyl, L, Pugacheva, D, Rajeev, PP, Romeo, S, Conti, M Rossetti, Rossi, AR, Rossmanith, R, Roussel, E, Sahai, AA, Sarri, G, Schaper, L, Scherkl, P, Schramm, U, Schroeder, CB, Scifo, J, Serafini, L, Sheng, ZM, Siders, C, Silva, LO, Silva, T, Simon, C, Sinha, U, Specka, A, Streeter, MJV, Svystun, EN, Symes, D, Szwaj, C, Tauscher, GE, Terzani, D, Thompson, N, Toci, G, Tomassini, P, Torres, R, Ullmann, D, Vaccarezza, C, Vannini, M, Vieira, JM, Villa, F, Wahlstrom, C-G, Walczak, R, Walker, PA, Wang, K, Welsch, CP, Wiggins, SM, Wolfenden, J, Xia, G, Yabashi, M, Zhu, J, Zigler, A, IOP, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique des gaz et des plasmas (LPGP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire pour l'utilisation des lasers intenses (LULI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'optique appliquée (LOA), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris), École polytechnique (X), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I. A., Aschikhin, A., Assmann, R. W., Audet, T., Bacci, A., Barna, I. F., Beaton, A., Beck, A., Beluze, A., Bernhard, A., Bielawski, S., Bisesto, F. G., Brandi, F., Brinkmann, R., Bruendermann, E., Buscher, M., Bussmann, M. H., Bussolino, G., Chance, A., Chen, M., Chiadroni, E., Cianchi, A., Clarke, J. A., Cole, J., Couprie, M. E., Croia, M., Cros, B., Crump, P. A., Dattoli, G., Del Dotto, A., Delerue, N., De Nicola, S., Dias, J. M., Dorda, U., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fiore, G., Fonseca, R. A., Galimberti, M., Gallo, A., Ghaith, A., Giove, D., Giribono, A., Gizzi, L. A., Gruner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Huebner, M., Irman, A., Jafarinia, F. J., Jaroszynski, D. A., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Blanc, C. L., Lechner, C., Leemans, W., Lehrach, A., Li, X., Libov, V., Lifschitz, A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marchetti, B., Martinez De La Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Molodozhentsev, A. Y., Mostacci, A., Mueller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Osterhoff, J., Oumbarek Espinos, D., Papadopoulos, D. N., Patrizi, B., Petrillo, V., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Rajeev, P. P., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Roussel, E., Sahai, A. A., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sheng, Z. M., Siders, C., Silva, L. O., Silva, T., Simon, C., Sinha, U., Specka, A., Streeter, M. J. V., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Thompson, N., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Vannini, M., Vieira, J. M., Villa, F., Wahlstrom, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, C. P., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhu, J., Zigler, A., Weikum, M K, Akhter, T, Alesini, D, Alexandrova, A S, Anania, M P, Andreev, N E, Andriyash, I A, Aschikhin, A, Assmann, R W, Audet, T, Bacci, A, Barna, I F, Beaton, A, Beck, A, Beluze, A, Bernhard, A, Bielawski, S, Bisesto, F G, Brandi, F, Brinkmann, R, Bruendermann, E, Büscher, M, Bussmann, M H, Bussolino, G, Chance, A, Chen, M, Chiadroni, E, Cianchi, A, Clarke, J A, Cole, J, Couprie, M E, Croia, M, Cros, B, Crump, P A, Dattoli, G, Del Dotto, A, Delerue, N, De Nicola, S, Dias, J M, Dorda, U, Fedele, R, Ferran Pousa, A, Ferrario, M, Filippi, F, Fiore, G, Fonseca, R A, Galimberti, M, Gallo, A, Ghaith, A, Giove, D, Giribono, A, Gizzi, L A, Grüner, F J, Habib, A F, Haefner, C, Heinemann, T, Hidding, B, Holzer, B J, Hooker, S M, Hosokai, T, Huebner, M, Irman, A, Jafarinia, F J, Jaroszynski, D A, Joshi, C, Kaluza, M, Kando, M, Karger, O S, Karsch, S, Khazanov, E, Khikhlukha, D, Knetsch, A, Kocon, D, Koester, P, Kononenko, O S, Korn, G, Kostyukov, I, Kruchinin, K O, Labate, L, Blanc, C Le, Lechner, C, Leemans, W, Lehrach, A, Li, X, Libov, V, Lifschitz, A, Litvinenko, V, Lu, W, Lundh, O, Maier, A R, Malka, V, Manahan, G G, Mangles, S P D, Marchetti, B, Martinez de la Ossa, A, Martins, J L, Mason, P D, Massimo, F, Mathieu, F, Maynard, G, Mazzotta, Z, Molodozhentsev, A Y, Mostacci, A, Mueller, A - S, Murphy, C D, Najmudin, Z, Nghiem, P A P, Nguyen, F, Niknejadi, P, Osterhoff, J, Oumbarek Espinos, D, Papadopoulos, D N, Patrizi, B, Petrillo, V, Pocsai, M A, Poder, K, Pompili, R, Pribyl, L, Pugacheva, D, Rajeev, P P, Romeo, S, Rossetti Conti, M, Rossi, A R, Rossmanith, R, Roussel, E, Sahai, A A, Sarri, G, Schaper, L, Scherkl, P, Schramm, U, Schroeder, C B, Scifo, J, Serafini, L, Sheng, Z M, Siders, C, Silva, L O, Silva, T, Simon, C, Sinha, U, Specka, A, Streeter, M J V, Svystun, E N, Symes, D, Szwaj, C, Tauscher, G E, Terzani, Davide, Thompson, N, Toci, G, Tomassini, P, Torres, R, Ullmann, D, Vaccarezza, C, Vannini, M, Vieira, J M, Villa, F, Wahlstrom, C - G, Walczak, R, Walker, P A, Wang, K, Welsch, C P, Wiggins, S M, Wolfenden, J, Xia, G, Yabashi, M, Zhu, J, and Zigler, A

Subjects
electron, History, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Physics and Astronomy(all), 01 natural sciences, 7. Clean energy, Plasmas, accelerators, 010305 fluids & plasmas, Education, Accelerator Physics, Acceleration, accelerators, Conceptual design, 0103 physical sciences, site, ddc:530, 010306 general physics, plasma, QC, Open innovation, Focus (computing), Detector, acceleration, Plasma acceleration, Accelerators and Storage Rings, Computer Science Applications, laser, MC3: Novel Particle Sources and Acceleration Techniques, Plasmas, Systems engineering, Physics::Accelerator Physics, Plasmas (physics) | Lasers | Laser wakefield
Abstract

The Horizon 2020 Project EuPRAXIA (European Plasma Research Accelerator with eXcellence In Applications) is producing a conceptual design report for a highly compact and cost-effective European facility with multi-GeV electron beams accelerated using plasmas. EuPRAXIA will be set up as a distributed Open Innovation platform with two construction sites, one with a focus on beam-driven plasma acceleration (PWFA) and another site with a focus on laser-driven plasma acceleration (LWFA). User areas at both sites will provide access to FEL pilot experiments, positron generation and acceleration, compact radiation sources, and test beams for HEP detector development. Support centres in four different countries will complement the pan-European implementation of this infrastructure., Proceedings of the 10th Int. Particle Accelerator Conf., IPAC2019, Melbourne, Australia

Published
2019
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16. Erratum to: EuPRAXIA Conceptual Design Report (The European Physical Journal Special Topics, (2020), 229, 24, (3675-4284), 10.1140/epjst/e2020-000127-8)

Author

Assmann R. W., Weikum M. K., Akhter T., Alesini D., Alexandrova A. S., Anania M. P., Andreev N. E., Andriyash I., Artioli M., Aschikhin A., Audet T., Bacci A., Barna I. F., Bartocci S., Bayramian A., Beaton A., Beck A., Bellaveglia M., Beluze A., Bernhard A., Biagioni A., Bielawski S., Bisesto F. G., Bonatto A., Boulton L., Brandi F., Brinkmann R., Briquez F., Brottier F., Brundermann E., Buscher M., Buonomo B., Bussmann M. H., Bussolino G., Campana P., Cantarella S., Cassou K., Chance A., Chen M., Chiadroni E., Cianchi A., Cioeta F., Clarke J. A., Cole J. M., Costa G., Couprie M. -E., Cowley J., Croia M., Cros B., Crump P. A., D'Arcy R., Dattoli G., Del Dotto A., Delerue N., Del Franco M., Delinikolas P., De Nicola S., Dias J. M., Di Giovenale D., Diomede M., Di Pasquale E., Di Pirro G., Di Raddo G., Dorda U., Erlandson A. C., Ertel K., Esposito A., Falcoz F., Falone A., Fedele R., Ferran Pousa A., Ferrario M., Filippi F., Fils J., Fiore G., Fiorito R., Fonseca R. A., Franzini G., Galimberti M., Gallo A., Galvin T. C., Ghaith A., Ghigo A., Giove D., Giribono A., Gizzi L. A., Gruner F. J., Habib A. F., Haefner C., Heinemann T., Helm A., Hidding B., Holzer B. J., Hooker S. M., Hosokai T., Hubner M., Ibison M., Incremona S., Irman A., Iungo F., Jafarinia F. J., Jakobsson O., Jaroszynski D. A., Jaster-Merz S., Joshi C., Kaluza M., Kando M., Karger O. S., Karsch S., Khazanov E., Khikhlukha D., Kirchen M., Kirwan G., Kitegi C., Knetsch A., Kocon D., Koester P., Kononenko O. S., Korn G., Kostyukov I., Kruchinin K. O., Labate L., Le Blanc C., Lechner C., Lee P., Leemans W., Lehrach A., Li X., Li Y., Libov V., Lifschitz A., Lindstrom C. A., Litvinenko V., Lu W., Lundh O., Maier A. R., Malka V., Manahan G. G., Mangles S. P. D., Marcelli A., Marchetti B., Marcouille O., Marocchino A., Marteau F., Martinez de la Ossa A., Martins J. L., Mason P. D., Massimo F., Mathieu F., Maynard G., Mazzotta Z., Mironov S., Molodozhentsev A. Y., Morante S., Mosnier A., Mostacci A., Muller A. -S., Murphy C. D., Najmudin Z., Nghiem P. A. P., Nguyen F., Niknejadi P., Nutter A., Osterhoff J., Oumbarek Espinos D., Paillard J. -L., Papadopoulos D. N., Patrizi B., Pattathil R., Pellegrino L., Petralia A., Petrillo V., Piersanti L., Pocsai M. A., Poder K., Pompili R., Pribyl L., Pugacheva D., Reagan B. A., Resta-Lopez J., Ricci R., Romeo S., Rossetti Conti M., Rossi A. R., Rossmanith R., Rotundo U., Roussel E., Sabbatini L., Santangelo P., Sarri G., Schaper L., Scherkl P., Schramm U., Schroeder C. B., Scifo J., Serafini L., Sharma G., Sheng Z. M., Shpakov V., Siders C. W., Silva L. O., Silva T., Simon C., Simon-Boisson C., Sinha U., Sistrunk E., Specka A., Spinka T. M., Stecchi A., Stella A., Stellato F., Streeter M. J. V., Sutherland A., Svystun E. N., Symes D., Szwaj C., Tauscher G. E., Terzani D., Toci G., Tomassini P., Torres R., Ullmann D., Vaccarezza C., Valleau M., Vannini M., Vannozzi A., Vescovi S., Vieira J. M., Villa F., Wahlstrom C. -G., Walczak R., Walker P. A., Wang K., Welsch A., Welsch C. P., Weng S. M., Wiggins S. M., Wolfenden J., Xia G., Yabashi M., Zhang H., Zhao Y., Zhu J., Zigler A., Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Brundermann, E., Buscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chance, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D'Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. 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Abstract

Figure 20.1 was not correct in the published article. The original article has been corrected. The published apologizes for the inconvenience.

Published
2020

20. Code design for radar STAP via optimization theory

Author

De Maio, A., De Nicola, S., Yongwei Huang Palomar, D.P. Shuzhong, and Zhang Farina, A.

Subjects
Gaussian processes -- Analysis, Mathematical optimization -- Usage, Radar systems -- Analysis, Signal processing -- Analysis, Waveforms -- Analysis, Digital signal processor, Business, Computers, Electronics, Electronics and electrical industries
Published
2010

22. Design of phase codes for radar performance optimization with a similarity constraint

Author

De Maio, A., De Nicola, S., Yongwei Huang, Zhi-Quan Luo, and Shuzhong Zhang

Subjects
Polynomials -- Usage, Radar systems -- Evaluation, Random noise theory -- Analysis, Signal processing -- Analysis, Waveforms -- Evaluation, Digital signal processor, Business, Computers, Electronics, Electronics and electrical industries
Published
2009

49. Imidazole-stabilized gold nanoparticles induce neuronal apoptosis: An in vitro and in vivo study

Author

Imperatore, R, Carotenuto, G, Di Grazia MA, Ferrandino, I, Palomba, Letizia, Mariotti, R, Vitale, E, De Nicola, S, Longo, A, Cristino, L., Imperatore, R., Carotenuto, G., Di Grazia, Ma, Ferrandino, I., Palomba, L, Mariotti, R., Vitale, E., De Nicola, S., Longo, A., and Cristino, L.

Subjects
Neurons, Time Factors, Imidazoles, apoptosis, Brain, Metal Nanoparticles, blood brain barrier, cytotoxicity, neuroblastoma, thiolato ligands, Blood-brain barrier, Endocytosis, nanoparticelle, barriera emato encefalica, apoptosi, Mice, Inbred C57BL, tumore, Injections, Intravenous, In Situ Nick-End Labeling, Animals, Humans, Tissue Distribution, Gold, Cell Shape
Abstract

Gold nanoparticles are increasingly being employed in innovative biological applications thanks to their advantages of material- and size-dependent physics and chemical interactions with the cellular systems. On the other hand, growing concern has emerged on the toxicity which would render gold-based nanoparticles harmful to cell cultures, animals, and humans. Emerging attention is focused on the interaction of gold nanoparticles with nervous system, especially regarding the ability to overcome the blood-brain barrier (BBB) which represents the major impediment to the delivery of therapeutics into the brain. We synthesized highly stable 2-mercapto-1-methylimidazole-stabilized gold-nanoparticles (AuNPs)-mmi to investigate their entry, accumulation, and toxicity in vitro (SH-SY5Y human neuroblastoma cells) and in vivo (brain of C57BL/6 mice) through optical and electron microscopy. After incubation in the cell culture medium at the lowest dose of 0.1 mg/mL the (AuNPs)-mmi nanoparticles were found compacted and recruited into endosome/lysosomes (1 h) before their fusion (2 h) and the onset of neuronal death by apoptosis (4 h) as proved by terminal-transferase-mediated dUTP nick end labeling assay and caspase-3 immunoreactivity. The ability of (AuNPs)-mmi to cross the BBB was assessed by injection in the caudal vein of C57BL/6 mice. Among different brain regions, the nanoparticles were found in the CaudatoPutamen area, mainly in the striatal neurons 4 h after injection. These neurons showed the typical hallmarks of apoptosis. Our findings provide, for the first time, the dynamic of 2-mercapto-1-methylimidazole nanogold uptake. The molecular mechanism which underlies the nanogold-driven apoptotic event is analyzed and discussed in order to take into account when designing nanomaterials to interface with biological structures. © 2014 Wiley Periodicals, Inc.

Published
2015
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