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Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi‐enzymatic sequence that allows to obtain vic‐halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method [ABSTRACT FROM AUTHOR]

Molecular hybridization is a widely used strategy in drug discovery and development processes that consists of the combination of two bioactive compounds toward a novel entity. In the current study, two libraries of hybrid derivatives coming from the linkage of sesquiterpene counterparts dihydroartemisinin and artesunic acid, with a series of monoterpenes, were synthesized and evaluated by cell viability assay on primary and metastatic melanoma cell lines. Almost all the obtained compounds showed micromolar antimelanoma activity and selectivity toward the metastatic form of this cancer. Four hybrid derivatives containing perillyl alcohol, citronellol, and nerol as monoterpene counterpart emerged as the best compounds of the series, with nerol being active in combination with both sesquiterpenes, dihydroartemisinin and artesunic acid. Preliminary studies on the mechanism of action have shown the dependence of the pharmacological activity of newly synthesized hybrids on the formation of carbon- and oxygen-centered radical species. This study demonstrated the positive modulation of the pharmacodynamic effect of artemisinin semisynthetic derivatives dihydroartemisinin and artesunic acid due to the hybridization with monoterpene counterparts. [ABSTRACT FROM AUTHOR]

The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that enable the modification of the chosen privileged framework and better explore the chemical space around it. In this study, two series of highly functionalized pyrimidine and pyridine derivatives were synthesized using a scaffold morphing approach consisting of triazine compounds obtained previously as antiviral agents. Newly synthesized azines were evaluated against lymphoma, hepatocarcinoma, and colon epithelial carcinoma cells, showing in five cases acceptable to good anticancer activity associated with low cytotoxicity on healthy fibroblasts. Finally, ADME in vitro studies were conducted on the best derivatives of the two series showing good passive permeability and resistance to metabolic degradation. [ABSTRACT FROM AUTHOR]

The first enantioselective reduction of 2‐substituted cyclic imines to the corresponding amines (pyrrolidines, piperidines, and azepines) by imine reductases (IREDs) in non‐conventional solvents is reported. The best results were obtained in a glycerol/phosphate buffer 1 : 1 mixture, in which heterocyclic amines were produced with full conversions (>99 %), moderate to good yields (22–84 %) and excellent S‐enantioselectivities (up to >99 % ee). Remarkably, the process can be performed at a 100 mM substrate loading, which, for the model compound, means a concentration of 14.5 g L−1. A fed‐batch protocol was also developed for a convenient scale‐up transformation, and one millimole of substrate 1 a was readily converted into 120 mg of enantiopure amine (S)‐2 a with a remarkable 80 % overall yield. This aspect strongly contributes to making the process potentially attractive for large‐scale applications in terms of economic and environmental sustainability for a good number of substrates used to produce enantiopure cyclic amines of high pharmaceutical interest. [ABSTRACT FROM AUTHOR]

Quinol derivatives of estrogens are effective pro-drugs in steroid replacement therapy. Here, we report that these compounds can be synthesized in one-pot conditions and high yield by blue LED-driven photo-oxygenation of parent estrogens. The oxidation was performed in buffer and eco-certified 2-methyltetrahydrofuran as the two-liquid-phase reaction solvent, and in the presence of meso-tetraphenyl porphyrin as the photosensitizer. Two steroidal prodrugs 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED) and 10β-Hydroxyestra-1,4-diene-3,17-dione (HEDD) were obtained with high yield and selectivity. [ABSTRACT FROM AUTHOR]

European consumers have generally been reluctant to accept genetically modified food. Novel breeding technologies that avoid transgenic manipulations seem to be more positively perceived by consumers, opening new horizons for the market. This paper investigates the motivations of consumer acceptance for cisgenic products. By comparing four information treatments (i.e., basic information, naturalness, health, and environment), we demonstrate that information on health-related benefits and especially on environmental benefits contributes to generate a positive communication landscape around cisgenic food. The results provide insights for the development of food policies and communication strategies aimed at increasing consumer acceptance for edited food. [ABSTRACT FROM AUTHOR]

This paper aims at extending current knowledge on consumer choice behavior on food produced through the application of NBT. We explore whether consumer time preferences and socioeconomic factors may have a role in affecting choice behavior involving cisgenic and conventional products. To this purpose we designed a hypothetical CE and used cisgenic apples as a case study. The results indicate that both time preferences and socioeconomic variables contribute to explain heterogeneity in preference for food products obtained through the application of biotechnologies and provide insight that could be relevant for both the agri‐biotech industry and for policy makers. [ABSTRACT FROM AUTHOR]

We conducted a field experiment to test the effect of nonmonetary incentives in increasing children's vegetable consumption during lunch at school. We measured children's daily vegetable consumption for four consecutive weeks prior to the provision of incentives, for four consecutive weeks during the incentive provision, and for three consecutive weeks right after the provision of incentives. To check the longer‐term effect of the incentive provision, we measured children's daily vegetable consumption 11 weeks after the postintervention period. Results suggest that the incentives are effective in increasing vegetable consumption and that this effect persisted several weeks after the provision of the incentives ended. This is an important topic since gaining a better understanding of effects of nonmonetary incentives can help in the design of nutrition and health policies aimed at improving the dietary behavior of children and potentially reducing childhood obesity. [ABSTRACT FROM AUTHOR]

In the last decade, cisgenic breeding emerged as a valuable alternative to transgenic genetic modification. Cisgenesis allows to obtain disease-resistant crops, thus reducing the need of chemical pesticides in the fields. This would imply a reduction of the environmental impact deriving from agricultural production. To concretely exploit the potential deriving from such biotechnology application, consumers' willingness to buy and consume such food is an essential matter. In this study we explore consumer choice behavior for cisgenic vs conventional apple alternatives through a hypothetical Choice Experiment, meanwhile examining attribute non-attendance behaviors. The Latent Class Model estimates reveal considerable differences across population segments in terms of choice behavior and preferences. In fact, while some consumers choose based on this attribute, a sizable segment of the population ignores it, suggesting that there may be room on the market for these products with potential implications in terms of environmental and food policy formulation. Unlabelled Image • Cisgenesis may contribute to reduce environmental impact of agricultural production. • Apple is used to test consumers' acceptance of cisgenic food. • Heterogeneity in preferences and Attribute Non-Attendance characterize the choice. • The production technology attribute is non-attended by a sizable part of the sample. • The technology used in the production process results to be the major driver of the choice. [ABSTRACT FROM AUTHOR]

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The reduction of diet-related diseases and the improvement of environmental sustainability represent two of the major 21st century food policy challenges. Sustainable diets could significantly contribute to achieving both of these goals, improving consumer health and reducing the environmental impact of food production and consumption. The Mediterranean diet (MD) represents an excellent example of sustainable diet, however recent evidence indicates that such a dietary pattern is now progressively disappearing in Mediterranean countries. In such a context, this paper explores how individual lifestyle and habits are related to a high/low adherence to the MD model. The goal is to examine whether there is a relationship between individuals' healthy and pro-environmental behaviors and their level of adherence to the MD. The analysis also explores the role of consumer income and education. The study is based on the Italian population (n = 42,000) and uses a structural equation model approach. The results outline that the MD is part of a sustainability-oriented lifestyle and stress the key role of both income and education in affecting adherence to MD. Future policy aimed at contrasting the gradual disappearance of the MD should emphasize the sustainable dimension of the MD, meanwhile reducing socio-economic disparities among different population segments. [ABSTRACT FROM AUTHOR]

Food labelling can play a key role in increasing consumers’ food-related consciousness, and improving the healthiness of their food choices. However consumers’ use of food labels is affected by a number of variables. The aim of this paper is to explore the role of health-orientation on consumers’ use of different labelled information, making a distinction between mandatory and voluntary information (namely, nutrition facts panel vs nutrition and health claims). Data were collected in Italy through face-to-face interviews on a sample of 300 consumers in charge of their grocery shopping. To evaluate the relationship between health-orientation and label usage we developed an index strictly based on the definition of health-orientation itself and included such measure in our analysis, which is based on a set of OLS regressions. The main results overall stress the idea that different degrees of health-orientation are, indeed, reflected in a diverse use of labelled information. Highly health-oriented consumers are more likely to refer to the extensive information reported on nutrition facts panel, whereas claims are of main interest for consumers with low orientation to health. The results also strengthen the key role played by nutrition knowledge and education in favouring a frequent usage of the nutrition facts panel and confirm previous findings on the relationship between socio-economic status and consumers use of labelled information. [ABSTRACT FROM AUTHOR]

Purpose – The purpose of this paper is to focus, first, on the analysis of recent trends of the European and Italian food industries, and, second, on the possible implications that the Transatlantic Trade and Investment Partnership (TTIP) negotiate can exert on the Italian agri-food system. Design/methodology/approach – The study is based on an in-depth analysis of current economic trends, characteristics of production structure, and the trade balance of Italy-USA commercial relationship in the context of EU market. The main advantages and disadvantages that can be derived from the TTIP negotiation are pointed out. Findings – The analysis of the Italian food industry highlights a very fragmented production structure characterized by the coexistence on the market of a small number of big companies and a large number of micro, small and medium-sized enterprises. Such bipolar structure constitutes a constraint to internationalization and limits the quantities of exportable products. The TTIP can represent an opportunity for the Italian food small businesses. On the other hand, the main disadvantages are related to the agricultural raw materials market. Originality/value – The study offers an in-depth analysis of the main features of the Italian food industry and of its role in international agri-food trades, describing the scenario that could be opened by the TTIP negotiation. [ABSTRACT FROM AUTHOR]

The mass production and use of plastics over the past decades is now posing a threat to the environment due to increasing pollution. The industrial transition towards more sustainable plastic alternatives has already started, but the process will require years to become truly feasible from an industrial and economic standpoint. In the meantime, a significant contribution to limit plastic-related environmental impact could arise from consumers' daily consumption choices. This study aims at investigating the determinants of consumers' decision to avoid purchasing single-use plastic eating utensils, food products with multiple plastic packaging, and plastic water bottles while grocery shopping. The results of the Structural Equation Model reveal that environment- and health-related concerns associated with plastics are key drivers of plastic avoidance. Instead, subjective knowledge and the importance attached to the commitment of third parties for tackling the plastic issue only indirectly affect consumer behaviors with regard to plastic avoidance. [ABSTRACT FROM AUTHOR]

According to the prediction of the Food and Agriculture Organization, food supply must increase by almost 70 percent by 2050, with tremendous consequences in terms of land depletion, natural resource use, and greenhouse gas emissions. The current agri-food system is incapable to cope with this raising demand meanwhile preserving the environment. There is urgent need to reorient the food system onto a more sustainable trajectory: producers should pursue more conscious and environmentally friendly practices and consumers should account for sustainability issues while making their daily food consumption decisions. The goal of this systematic review is to gather existing evidence on green nudging interventions geared at leveraging more environmentally sustainable behaviours among the agents of the food chain, from the producers to the final consumers. An extensive literature search was conducted on Web of Science, Scopus, EconLit, and CAB Abstracts, restricting the selection to the last ten years, and using "nudg*" or "choice architecture" as primary research strings. Finally, 25 studies were included in the review. Almost all studies on farmers as well as on consumers included in this review provide evidence that green nudging can be effective in leveraging more sustainable practices. Overall, we propose that green nudges should not be meant to replace stricter environmental and food policies , but rather they should be regarded as potential complements to be implemented with the aim of gradually moving society in a direction that might benefit all. • The agri-food system is unable to satisfy the raising food demand in a sustainable way. • There is urgent need to reorient the food system onto a more sustainable trajectory. • Policies based on green-nudging may be a promising way to address sustainability goals. • Green nudging can leverage sustainable behaviours among the agents of the food chain. • Green nudges can contribute to move firms and consumers towards sustainable behaviors. [ABSTRACT FROM AUTHOR]