40 results on '"De Magistris, Maria Santucci"'
Search Results
2. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study
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Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio
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- 2023
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3. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R., Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W.M. Monique, Enget Jensen, Torill M., Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J. Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K., Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse
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- 2023
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4. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study
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Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
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- 2022
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5. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study
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Iglesias-Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K., Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo-Sánchez, Daniel, de Magistris, Maria Santucci, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, Ramón, Amiano, Pilar, Agudo, Antonio, and Jakszyn, Paula
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- 2022
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6. Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study.
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Pham, Thu Thi, Nimptsch, Katharina, Aleksandrova, Krasimira, Jenab, Mazda, Fedirko, Veronika, Wu, Kana, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Rothwell, Joseph, Kaaks, Rudolf, Katzke, Verena, Catalano, Alberto, Agnoli, Claudia, Masala, Giovanna, De Magistris, Maria Santucci, Tumino, Rosario, Vermeulen, Roel, Aizpurua, Amaia, and Trobajo‐Sanmartín, Camino
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RESISTIN ,COLORECTAL cancer ,PROPORTIONAL hazards models ,BODY mass index - Abstract
Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre‐diagnostic serum resistin concentrations in relation to CRC‐specific and all‐cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC‐specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause‐specific Cox proportional hazards models and further in sensitivity analyses using Fine–Gray proportional subdistribution hazards models. For all‐cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow‐up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC‐specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73–1.23; Ptrend =.97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84–1.19; P =.98) or all‐cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre‐diagnostic circulating resistin concentrations and CRC‐specific or all‐cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
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Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Fortner, Renée T., Boeing, Heiner, Ramón Quirós, J., Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, De Magistris, Maria Santucci, Bueno-de-Mesquita, H. B., Peeters, Petra H., Wennberg, Maria, Bergdahl, Ingvar A., Vesper, Hubert, Riboli, Elio, and Duell, Eric J.
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- 2017
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8. Prediagnostic serum glyceraldehyde‐derived advanced glycation end products and mortality among colorectal cancer patients.
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Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., and Skeie, Guri
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ADVANCED glycation end-products ,COLORECTAL cancer ,CANCER patients ,PROPORTIONAL hazards models ,COLON cancer - Abstract
Glyceraldehyde‐derived advanced glycation end products (glycer‐AGEs) could contribute to colorectal cancer development and progression due to their pro‐oxidative and pro‐inflammatory properties. However, the association of glycer‐AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer‐AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer‐AGEs concentrations with CRC‐specific and all‐cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow‐up, 529 participants died (409 from CRC). Glycer‐AGEs were statistically significantly positively associated with CRC‐specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04‐2.25, Ptrend =.002) and all‐cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16‐2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer‐AGEs and CRC‐specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74‐1.42; HRdistal colon = 1.51, 95% CI: 1.20‐1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer‐AGEs category relative to lowest BMI and glycer‐AGEs category for both CRC‐specific (HR = 1.78, 95% CI: 1.02‐3.01) and all‐cause mortality (HR = 2.15, 95% CI: 1.33‐3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer‐AGEs are positively associated with CRC‐specific and all‐cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries
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Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne-Claire, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H. M., and Slimani, Nadia
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- 2016
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10. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hémon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartåker, Anette, Menéndez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin
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- 2016
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11. Dietary Intakes of Animal and Plant Proteins and Risk of Colorectal Cancer: The EPIC-Italy Cohort.
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Sieri, Sabina, Agnoli, Claudia, Pala, Valeria, Grioni, Sara, Palli, Domenico, Bendinelli, Benedetta, Macciotta, Alessandra, Ricceri, Fulvio, Panico, Salvatore, De Magistris, Maria Santucci, Tumino, Rosario, Fontana, Luigi, and Krogh, Vittorio
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CONFIDENCE intervals ,COLORECTAL cancer ,PLANT proteins ,FOOD animals ,GLYCEMIC index ,QUESTIONNAIRES ,DIETARY proteins ,CHOLESTEROL ,LONGITUDINAL method ,DISEASE risk factors - Abstract
Simple Summary: After breast and prostate cancer, colorectal (CRC) is the third most frequent cancer in men and women. It is unclear if protein-rich diets other than red meat elevate risk or even lower CRC occurrence at specific colon locations. The aim of this study is to assess the associations of animal and plant protein intakes with CRC risk in middle-aged Italian men and women. Our findings show that replacing animal proteins with plant proteins was associated with a lower risk of rectal cancer but not of colon cancer, while replacing animal proteins with plant-based proteins from high-glycemic-index (GI) foods was associated with an increased colon cancer risk. These results have important public health implications as they suggest that both refined high-GI foods and meat might have site-specific roles in the pathogenesis of CRC. We prospectively investigated the associations of protein intake with colorectal cancer (CRC) risk in middle-aged Italian men and women. Food consumption was assessed by validated Epic semiquantitative food-frequency questionnaires. Multivariable Cox models stratified by center, age, and sex, adjusted for confounders, estimated the associations of animal and plant protein consumption with CRC risk by subsite. Among 44,824 men and women, we identified 539 incident CRCs after a median follow-up of 14 years. Replacing animal proteins with plant proteins was associated with a decreased risk of rectal (HR, 0.71; 95% CI, 0.55–0.92) but not colon cancer. By contrast, replacing animal proteins with plant proteins from high-glycemic-index (GI) foods was associated with an increased risk of proximal and distal (including sigma) colon cancer (HR, 1.23; 95% CI, 1.07–1.40) but not when animal proteins were replaced with plant proteins from low-GI foods (HR, 0.93; 95% CI, 0.79–1.11). Further evaluation revealed that the increased colon cancer risk was limited to the substitution of proteins from red and processed meat, as well as dairy and eggs, with vegetable proteins from high-GI foods. Participants in the highest quintile of animal protein intake had higher plasma glucose and cholesterol levels than those in the lowest quintile. By contrast, higher intake of plant proteins from low-GI foods was inversely associated with fasting insulin and HOMA-IR levels. In conclusion, replacing animal proteins with plant proteins from high-GI foods was associated with an increased risk of colon cancer. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries
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Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, van der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Réseau National Alimentation Cancer Recherche (réseau NACRe), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health, Imperial College London, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Institute of Nutrition Science, University of Potsdam, Hellenic Health Foundation, 'Attikon' University Hospital, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], AOU Federico II, Partenaires INRAE, Provincial Health Services Authority, Center for Cancer Prevention (CPO-Piemonte), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], The Arctic University of Norway (UiT), Public Health Directorate, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Andalusian School of Public Health [Granada], Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain, parent, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Navarra Institute for Health Research, Biodonostia Health Research Institute, Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède], Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, University of Cambridge School of Clinical Medicine, University of Ioannina School of Medicine, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], French National Cancer Institute (INCa)-Canceropole Ile-de-France 2017-1-PL SHS-01-INSERM ADR 5-1Fondation Recherche Medicale ARF201809007046European CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeFederal Ministry of Education & Research (BMBF)Hellenic Health Foundation (Greece)Associazione Italiana per la Ricerca sul Cancro (AIRC)Italian National Research CouncilDutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de Andalucia Regional government of Asturias (Spain) Regional government of Basque Country (Spain) Regional government of Murcia (Spain) Regional government of Navarra (Spain) Catalan Institute of Oncology (Spain)Swedish Cancer Society Swedish Scientific Council (Sweden) County councils of Skane and Vasterbotten (Sweden)Cancer Research UK C864/A14136 C8221/A19170Medical Research Council UK (MRC) MR/N003284/1 - MC-UU_12015/1 - MR/M012190/1 - MC_UU_12015/1 - MC_UU_12015/5 - National Institute for Health Research Biomedical Research Centre, Cambridge: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, Deschasaux, Mélanie [0000-0002-3359-420X], and Apollo - University of Cambridge Repository
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Adult ,Male ,1117 Public Health and Health Services ,Cohort Studies ,Food Preferences ,Food Labeling ,General & Internal Medicine ,Surveys and Questionnaires ,Mortalitat ,Humans ,Mortality ,Nutrició ,ComputingMilieux_MISCELLANEOUS ,Nutrition ,Proportional Hazards Models ,Research ,Klinisk medicin ,1103 Clinical Sciences ,Middle Aged ,Europe ,Nutrition Assessment ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Clinical Medicine ,Nutritive Value ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, PConclusions: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.
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- 2020
13. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition1–3
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Saadatian-Elahi, Mitra, Slimani, Nadia, Chajès, Véronique, Jenab, Mazda, Goudable, Joëlle, Biessy, Carine, Ferrari, Pietro, Byrnes, Graham, Autier, Philippe, Peeters, Petra HM, Ocké, Marga, de Mesquita, Bas Bueno, Johansson, Ingegerd, Hallmans, Goran, Manjer, Jonas, Wirfält, Elisabet, Gonzalez, Carlos A, Navarro, Carmen, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Noethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Oustoglou, Erifili, Clavel-Chapelon, Françoise, and Riboli, Elio
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- 2009
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14. Dietary intake of animal and plant proteins and risk of all cause and cause-specific mortality: The Epic-Italy cohort.
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Fontana, Luigi, Sieri, Sabina, Ricceri, Fulvio, Agnoli, Claudia, Pala, Valeria, Masala, Giovanna, Saieva, Calogero, Catalano, Alberto, Macciotta, Alessandra, Tumino, Rosario, Panico, Salvatore, De Magistris, Maria Santucci, and Krogh, Vittorio
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PLANT proteins ,LDL cholesterol ,PLANT mortality ,MEDITERRANEAN diet ,MIDDLE-aged men ,MIDDLE-aged persons ,FOOD consumption ,CARBOHYDRATE content of food - Abstract
BACKGROUND: To examine the associations of animal and plant protein intake with all-cause, cardiovascular and cancer mortality risk in middle-aged Italian men and women with substantially lower animal protein intake than North Americans. METHODS AND RESULTS: Food consumption was assessed by validated Epic semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex, and adjusted for confounders, estimated associations of animal and plant protein consumption with mortality for all causes, cardiovascular disease, and cancer. After a median follow-up of 15.2 years, 2,449 deaths were identified in 45,009 participants. No significant association between intake of total, animal or plant protein and mortality was found in the fully adjusted models. Substitution of plant protein for animal protein was inversely associated with cardiovascular mortality (HR, 0.47; 95% CI, 0.24–0.92) only in people with at least 1 unhealthy lifestyle risk factor and poor adherence to a Mediterranean diet. Participants in the highest quintile group of animal protein intake had higher glucose, total and LDL cholesterol levels than those in the lowest quintile. In contrast, higher plant protein intake was negatively associated with fasting insulin and cholesterol, despite higher BMI, physical inactivity and starch consumption. CONCLUSIONS: Replacing plant protein for animal protein was associated with lower cardiovascular mortality among individuals with unhealthy lifestyle risk factors. High animal but not plant protein intake is associated with impaired fasting glucose and hypercholesterolemia, despite lower calorie and carbohydrate intake, suggesting that protein source plays crucial roles in modulating cardiometabolic health independently of body weight. [ABSTRACT FROM AUTHOR]
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- 2021
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15. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
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Clasen, Joanna L, Heath, Alicia K, Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C, Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B, Masala, Giovanna, Segrado, Francesco, and de Magistris, Maria Santucci
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VITAMIN B6 metabolism ,BIOMARKERS ,HOMOCYSTEINE ,CYSTEINE ,PYRIDINE ,LIFESTYLES ,VITAMIN B6 ,PREDICTIVE tests ,CONFIDENCE intervals ,VITAMIN B6 deficiency ,INGESTION ,REGRESSION analysis ,DESCRIPTIVE statistics ,AMINO acids - Abstract
Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions We found that 5 different markers, capturing different aspects of vitamin B6–related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
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Obon-Santacana, Mireia Lujan-Barroso, Leila Freisling, Heinz and Cadeau, Claire Fagherazzi, Guy Boutron-Ruault, Marie-Christine and Kaaks, Rudolf Fortner, Renee T. Boeing, Heiner Quiros, J. Ramon Molina-Montes, Esther Chamosa, Saioa Castano, Jose Maria Huerta Ardanaz, Eva Khaw, Kay-Tee Wareham, Nick and Key, Tim Trichopoulou, Antonia Lagiou, Pagona Naska, Androniki Palli, Domenico Grioni, Sara Tumino, Rosario and Vineis, Paolo De Magistris, Maria Santucci Bueno-de-Mesquita, H. B. Peeters, Petra H. Wennberg, Maria Bergdahl, Ingvar A. and Vesper, Hubert Riboli, Elio Duell, Eric J.
- Abstract
Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide ( HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in nonsmoking postmenopausal women from the EPIC cohort.
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- 2017
17. Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries
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Noh, Hwayoung Freisling, Heinz Assi, Nada Zamora-Ros, Raul and Achaintre, David Affret, Aurelie Mancini, Francesca and Boutron-Ruault, Marie-Christine Floegel, Anna Boeing, Heiner and Kuehn, Tilman Schuebel, Ruth Trichopoulou, Antonia Naska, Androniki Kritikou, Maria Palli, Domenico Pala, Valeria and Tumino, Rosario Ricceri, Fulvio de Magistris, Maria Santucci and Cross, Amanda Slimani, Nadia Scalbert, Augustin Ferrari, Pietro
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food and beverages - Abstract
We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ). Thirty-four polyphenols were measured by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS-MS) in 24-h urine. Reduced rank regression-based variable importance in projection (RRR-VIP) and least absolute shrinkage and selection operator (LASSO) methods were used to select polyphenol metabolites. Reduced rank regression (RRR) was then used to identify patterns in these metabolites, maximizing the explained variability in intake of pre-selected polyphenol-rich foods. The performance of RRR models was evaluated using internal cross-validation to control for over-optimistic findings from over-fitting. High performance was observed for explaining recent intake (24-HDR) of red wine (r = 0.65; AUC = 89.1%), coffee (r = 0.51; AUC = 89.1%), and olives (r = 0.35; AUC = 82.2%). These metabolite patterns performed better or equally well compared to single polyphenol biomarkers. Neither metabolite patterns nor single biomarkers performed well in explaining habitual intake (as reported in the DQ) of polyphenol-rich foods. This proposed strategy of biomarker pattern identification has the potential of expanding the currently still limited list of available dietary intake biomarkers.
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- 2017
18. Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
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Zamora-Ros, Raul Barupal, Dinesh K. Rothwell, Joseph A. and Jenab, Mazda Fedirko, Veronika Romieu, Isabelle and Aleksandrova, Krasimira Overvad, Kim Kyro, Cecilie and Tjonneland, Anne Affret, Aurelie His, Mathilde and Boutron-Ruault, Marie-Christine Katzke, Verena Kuehn, Tilman and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Kritikou, Maria Saieva, Calogero Agnoli, Claudia de Magistris, Maria Santucci Tumino, Rosario Fasanelli, Francesca and Weiderpass, Elisabete Skeie, Guri Merino, Susana and Jakszyn, Paula Sanchez, Maria-Jose Dorronsoro, Miren and Navarro, Carmen Ardanaz, Eva Sonestedt, Emily Ericson, Ulrika Nilsson, Lena Maria Boden, Stina Bueno-de-Mesquita, H. B. (as) Peeters, Petra H. Perez-Cornago, Aurora Wareham, Nicholas J. Khaw, Kay-Thee Freisling, Heinz Cross, Amanda J. and Riboli, Elio Scalbert, Augustin
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fungi ,food and beverages ,heterocyclic compounds - Abstract
Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
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- 2017
19. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries
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Freisling, Heinz Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Moskal, Aurelie Dahm, Christina C. Vergnaud, Anne-Claire Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Cadeau, Claire Kuehn, Tilman Neamat-Allah, Jasmine Buijsse, Brian Boeing, Heiner Halkjaer, Jytte Tjonneland, Anne and Hansen, Camilla P. Ramon Quiros, J. Travier, Noemie and Molina-Montes, Esther Amiano, Pilar Huerta, Jose M. and Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas Key, Tim J. Romaguera, Dora Lu, Yunxia Lassale, Camille M. Naska, Androniki Orfanos, Philippos Trichopoulou, Antonia Masala, Giovanna Pala, Valeria Berrino, Franco Tumino, Rosario and Ricceri, Fulvio de Magistris, Maria Santucci Bueno-de-Mesquita, H. Bas Ocke, Marga C. Sonestedt, Emily Ericson, Ulrika and Johansson, Mattias Skeie, Guri Weiderpass, Elisabete and Braaten, Tonje Peeters, Petra H. M. Slimani, Nadia
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Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. This study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders. Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.
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- 2016
20. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Assi, Nada Moskal, Aurelie Slimani, Nadia Viallon, Vivian and Chajes, Veronique Freisling, Heinz Monni, Stefano and Knueppel, Sven Foerster, Jana Weiderpass, Elisabete and Lujan-Barroso, Leila Amiano, Pilar Ardanaz, Eva and Molina-Montes, Esther Salmeron, Diego Ramon Quiros, Jose and Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim and Dossus, Laure Fournier, Agnes Baglietto, Laura Fortner, Renee Turzanski Kaaks, Rudolf Trichopoulou, Antonia Bamia, Christina Orfanos, Philippos De Magistris, Maria Santucci and Masala, Giovanna Agnoli, Claudia Ricceri, Fulvio Tumino, Rosario de Mesquita, H. Bas Bueno Bakker, Marije F. Peeters, Petra H. M. Skeie, Guri Braaten, Tonje Winkvist, Anna and Johansson, Ingegerd Khaw, Kay-Tee Wareham, Nicholas J. Key, Tim Travis, Ruth Schmidt, Julie A. Merritt, Melissa A. and Riboli, Elio Romieu, Isabelle Ferrari, Pietro
- Abstract
Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison. Setting The European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects Women (n 334 850) from the EPIC study. Results The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B-12 and D, while the second TT component (TC2) reflected a diet rich in -carotene, riboflavin, thiamin, vitamins C and B-6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=089, 95 % CI 083, 095, P-trend
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- 2016
21. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition
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Leenders, Max, Siersema, Peter D, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, De Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J, Murphy, Neil, Riboli, Elio, Bueno-de-Mesquita, H Bas, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, and LS IRAS EEPI GRA (Gezh.risico-analyse)
- Abstract
Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95%CI 0.75-1.01, P for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than ten years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but seems unlikely. This article is protected by copyright. All rights reserved.
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- 2015
22. The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk
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Kong, So Yeon Takeuchi, Masayoshi Hyogo, Hideyuki and McKeown-Eyssen, Gail Yamagishi, Sho-Ichi Chayama, Kazuaki and O'Brien, Peter J. Ferrari, Pietro Overvad, Kim Olsen, Anja and Tjonneland, Anne Boutron-Ruault, Marie-Christine Bastide, Nadia Carbonnel, Franck Kuehn, Tilman Kaaks, Rudolf and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Vasilopoulou, Effie Masala, Giovanna Pala, Valeria De Magistris, Maria Santucci Tumino, Rosario and Naccarati, Alessio Bueno-De-Mesquita, H. B. Peeters, Petra H. and Weiderpass, Elisabete Quiros, J. Ramon Jakszyn, Paula and Sanchez, Maria-Jose Dorronsoro, Miren Gavrila, Diana and Ardanaz, Eva Rutegard, Martin Nystroem, Hanna Wareham, Nicholas J. Khaw, Kay-Tee Bradbury, Kathryn E. Romieu, Isabelle Freisling, Heinz Stavropoulou, Faidra Gunter, Marc J. Cross, Amanda J. Riboli, Elio Jenab, Mazda Bruce, W. Robert
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Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1: 1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.571.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development. (C) 2015 AACR.
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- 2015
23. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition
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Leenders, Max Siersema, Peter D. Overvad, Kim Tjonneland, Anne Olsen, Anja Boutron-Ruault, Marie-Christine Bastide, Nadia Fagherazzi, Guy Katzke, Verena Kuehn, Tilman and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Klinaki, Eleni Masala, Giovanna Grioni, Sara and De Magistris, Maria Santucci Tumino, Rosario Ricceri, Fulvio and Peeters, Petra H. M. Lund, Eiliv Skeie, Guri Weiderpass, Elisabete Ramon Quiros, J. Agudo, Antonio Sanchez, Maria-Jose Dorronsoro, Miren Navarro, Carmen Ardanaz, Eva and Ohlsson, Bodil Jirstroem, Karin Van Guelpen, Bethany and Wennberg, Maria Khaw, Kay-Tee Wareham, Nick Key, Timothy J. and Romieu, Isabelle Huybrechts, Inge Cross, Amanda J. and Murphy, Neil Riboli, Elio Bueno-de-Mesquita, H. B(As)
- Abstract
Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and a variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of 13 years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than 10 years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but appears unlikely.
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- 2015
24. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study
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Moskal, Aurelie Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Freisling, Heinz Boutron-Ruault, Marie-Christine and Cadeau, Claire Nailler, Laura Wendt, Andrea Kuehn, Tilman and Boeing, Heiner Buijsse, Brian Tjonneland, Anne Halkjaer, Jytte Dahm, Christina C. Chiuve, Stephanie E. Quiros, Jose R. Buckland, Genevieve Molina-Montes, Esther Amiano, Pilar and Huerta Castano, Jose M. Barricarte Gurrea, Aurelio Khaw, Kay-Tee Lentjes, Marleen A. Key, Timothy J. Romaguera, Dora and Vergnaud, Anne-Claire Trichopoulou, Antonia Bamia, Christina and Orfanos, Philippos Palli, Domenico Pala, Valeria Tumino, Rosario Sacerdote, Carlotta de Magistris, Maria Santucci and Bueno-de-Mesquita, H. Bas Ocke, Marga C. Beulens, Joline W. J. and Ericson, Ulrika Drake, Isabel Nilsson, Lena M. Winkvist, Anna Weiderpass, Elisabete Hjartaker, Anette Riboli, Elio and Slimani, Nadia
- Abstract
Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings: We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance: The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.
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- 2014
25. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Zamora-Ros, Raul Knaze, Viktoria Lujan-Barroso, Leila and Romieu, Isabelle Scalbert, Augustin Slimani, Nadia and Hjartaker, Anette Engeset, Dagrun Skeie, Guri Overvad, Kim and Bredsdorff, Lea Tjonneland, Anne Halkjaer, Jytte Key, Timothy J. Khaw, Kay-Tee Mulligan, Angela A. Winkvist, Anna and Johansson, Ingegerd Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Wallstrom, Peter Ericson, Ulrika Pala, Valeria de Magistris, Maria Santucci Polidoro, Silvia Tumino, Rosario and Trichopoulou, Antonia Dilis, Vardis Katsoulis, Michael Maria Huerta, Jose Martinez, Virginia Sanchez, Maria-Jose Ardanaz, Eva Amiano, Pilar Teucher, Birgit Grote, Verena and Bendinelli, Benedetta Boeing, Heiner Foerster, Jana and Touillaud, Marina Perquier, Florence Fagherazzi, Guy Gallo, Valentina Riboli, Elio Gonzalez, Carlos A.
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food and beverages - Abstract
A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35 628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft (R)). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373.7 mg/d) and MED countries (370.2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48.2 %) and flavan-3-ol monomers (24.9 %) and the principal food sources were tea (25.7 %) and fruits (32.8 %). In the MED region, proanthocyanidins (59.0 %) were by far the most abundant contributor and fruits (55.1 %), wines (16.7 %) and tea (6.8 %) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.
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- 2013
26. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort
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Zamora-Ros, Raul Knaze, Viktoria Lujan-Barroso, Leila and Slimani, Nadia Romieu, Isabelle Fedirko, Veronika de Magistris, Maria Santucci Ericson, Ulrica Amiano, Pilar and Trichopoulou, Antonia Dilis, Vardis Naska, Androniki and Engeset, Dagrun Skeie, Guri Cassidy, Aedin Overvad, Kim and Peeters, Petra H. M. Maria Huerta, Jose Sanchez, Maria-Jose and Ramon Quiros, J. Sacerdote, Carlotta Grioni, Sara Tumino, Rosario Johansson, Gerd Johansson, Ingegerd Drake, Isabel and Crowe, Francesca L. Barricarte, Aurelio Kaaks, Rudolf and Teucher, Birgit Bueno-de-Mesquita, H. Bas van Rossum, Caroline T. M. Norat, Teresa Romaguera, Dora Vergnaud, Anne-Claire and Tjonneland, Anne Halkjaer, Jytte Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine Touillaud, Marina Salvini, Simonetta Khaw, Kay-Thee Wareham, Nicholas Boeing, Heiner and Foerster, Jana Riboli, Elio Gonzalez, Carlos A.
- Abstract
Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their food sources for 36 037 subjects, aged between 35 and 74 years, in twenty-seven study centres were obtained using standardised 24 h dietary recall software (EPIC-SOFT). An ad hoc food composition database on FLAV was compiled using data from US Department of Agriculture and Phenol-Explorer databases and was expanded using recipes, estimations and flavonoid retention factors in order to increase its correspondence with the 24 h dietary recall. Our results showed that the highest FLAV-consuming centre was the UK health-conscious group, with 130.9 and 97.0 mg/d for men and women, respectively. The lowest FLAV intakes were 36.8 mg/d in men from Umea and 37.2 mg/d in women from Malmo (Sweden). The flavanone sub-class was the main contributor to the total FLAV intake ranging from 46.6 to 52.9% depending on the region. Flavonols ranged from 38.5 to 47.3% and flavones from 5.8 to 8.6%. FLAV intake was higher in women, non-smokers, increased with level of education and physical activity. The major food sources were citrus fruits and citrus-based juices (especially for flavanones), tea, wine, other fruits and some vegetables. We concluded that the present study shows heterogeneity in intake of these three sub-classes of flavonoids across European regions and highlights differences by sex and other sociodemographic and lifestyle factors.
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- 2011
27. Eating out of home and its correlates in 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Orfanos, Philippos Naska, Androniki Trichopoulos, Dimitrios and Slimani, Nadia Ferrari, Pietro van Bakel, Marit Deharveng, Genevieve Overvad, Kim Tionneland, Anne Halkjaer, Jytte and de Magistris, Maria Santucci Tumino, Rosario Pala, Valeria and Sacerdote, Carlotta Masala, Giovanna Skeie, Guri Engeset, Dagrun Lund, Eiliv Jakszyn, Paula Barricarte, Aurelio and Chirlaque, Maria-Dolores Martinez-Garcia, Carmen Amiano, Pilar and Quiros, J. Ramon Bingham, Sheila Welch, Ailsa Spencer, Elizabeth A. Key, Timothy J. Rohrmann, Sabine Linseisen, Jakob Ray, Jennifer Boeing, Heiner Peeters, Petra H. and Bueno-De-Mesquita, H. Bas Ocke, Marga Johansson, Ingegerd and Johansson, Gerd Berglund, Goran Manjer, Jonas and Boutron-Ruault, Marie-Christine Touvier, Mathilde and Clavel-Chapelon, Francoise Trichopoulou, Antonia
- Abstract
Objective: To compare the average out-of-home (OH) consumption of foods and beverages, as well as energy intake, among populations from 10 European countries and to describe the characteristics of substantial OH caters, as defined for the purpose of the present study, in comparison to other individuals. Design: Cross-sectional study. Dietary data were collected through single 24-hour dietary recalls, in which the place of consumption was recorded. For the present study, substantial OH eaters were defined as those who consumed more than 25% of total daily energy intake at locations other than the household premises. Mean dietary intakes and the proportion of substantial OH eaters are presented by food group and country. Logistic regression analyses were used to estimate the odds of being a substantial OH eater in comparison to not being one, using mutually adjusted possible non-dietary determinants. Setting: Ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects: The subjects were 34 270 individuals, 12 537 men and 21733 women, aged 35-74 years. Results: The fraction of energy intake during OH eating was generally higher in northern European countries than in the southern ones. Among the food and beverage groups, those selectively consumed outside the home were coffee/tea/waters and sweets and, to a lesser extent, cereals, meats, added lipids and vegetables. Substantial OH eating was positively associated with energy intake and inversely associated with age and physical activity. Substantial OH eating was less common among the less educated compared with the more educated, and more common during weekdays in central and north Europe and during the weekend in south Europe. Conclusions: Eating outside the home was associated with sedentary lifestyle and increased energy intake; it was more common among the young and concerned in particular coffee/tea/waters and sweets.
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- 2007
28. Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries.
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Hwayoung Noh, Freisling, Heinz, Assi, Nada, Zamora-Ros, Raul, Achaintre, David, Affret, Aurélie, Mancini, Francesca, Boutron-Ruault, Marie-Christine, Flögel, Anna, Boeing, Heiner, Kühn, Tilman, Schübel, Ruth, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Ricceri, Fulvio, and De Magistris, Maria Santucci
- Abstract
We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ). Thirty-four polyphenols were measured by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS-MS) in 24-h urine. Reduced rank regression-based variable importance in projection (RRR-VIP) and least absolute shrinkage and selection operator (LASSO) methods were used to select polyphenol metabolites. Reduced rank regression (RRR) was then used to identify patterns in these metabolites, maximizing the explained variability in intake of pre-selected polyphenol-rich foods. The performance of RRR models was evaluated using internal cross-validation to control for over-optimistic findings from over-fitting. High performance was observed for explaining recent intake (24-HDR) of red wine (r = 0.65; AUC = 89.1%), coffee (r = 0.51; AUC = 89.1%), and olives (r = 0.35; AUC = 82.2%). These metabolite patterns performed better or equally well compared to single polyphenol biomarkers. Neither metabolite patterns nor single biomarkers performed well in explaining habitual intake (as reported in the DQ) of polyphenol-rich foods. This proposed strategy of biomarker pattern identification has the potential of expanding the currently still limited list of available dietary intake biomarkers. [ABSTRACT FROM AUTHOR]
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- 2017
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29. Dietary intakes and food sources of phenolic acids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
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Zamora-Ros, Raul, Rothwell, Joseph A., Scalbert, Augustin, Knaze, Viktoria, Romieu, Isabelle, Slimani, Nadia, Fagherazzi, Guy, Perquier, Florence, Touillaud, Marina, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Menéndez, Virginia, Tumino, Rosario, de Magistris, Maria Santucci, Palli, Domenico, Ricceri, Fulvio, Sieri, Sabina, and Crowe, Francesca L.
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AUTOMATIC data collection systems ,FOOD ,INGESTION ,INTERVIEWING ,LONGITUDINAL method ,MEDICAL cooperation ,PHENOLS ,RESEARCH ,RESEARCH funding ,LIFESTYLES - Abstract
Phenolic acids are secondary plant metabolites that may have protective effects against oxidative stress, inflammation and cancer in experimental studies. To date, limited data exist on the quantitative intake of phenolic acids. We estimated the intake of phenolic acids and their food sources and associated lifestyle factors in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Phenolic acid intakes were estimated for 36 037 subjects aged 35–74 years and recruited between 1992 and 2000 in ten European countries using a standardised 24 h recall software (EPIC-Soft), and their food sources were identified. Dietary data were linked to the Phenol-Explorer database, which contains data on forty-five aglycones of phenolic acids in 452 foods. The total phenolic acid intake was highest in Aarhus, Denmark (1265·5 and 980·7 mg/d in men and women, respectively), while the intake was lowest in Greece (213·2 and 158·6 mg/d in men and women, respectively). The hydroxycinnamic acid subclass was the main contributor to the total phenolic acid intake, accounting for 84·6–95·3 % of intake depending on the region. Hydroxybenzoic acids accounted for 4·6–14·4 %, hydroxyphenylacetic acids 0·1–0·8 % and hydroxyphenylpropanoic acids ≤ 0·1 % for all regions. An increasing south–north gradient of consumption was also found. Coffee was the main food source of phenolic acids and accounted for 55·3–80·7 % of the total phenolic acid intake, followed by fruits, vegetables and nuts. A high heterogeneity in phenolic acid intake was observed across the European countries in the EPIC cohort, which will allow further exploration of the associations with the risk of diseases. [ABSTRACT FROM PUBLISHER]
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- 2013
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30. Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
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Almanza-Aguilera, Enrique, Ceballos-Sánchez, Daniela, Achaintre, David, Rothwell, Joseph A, Laouali, Nasser, Severi, Gianluca, Katzke, Verena, Johnson, Theron, Schulze, Matthias B, Palli, Domenico, Gargano, Giuliana, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Scalbert, Augustin, and Zamora-Ros, Raul
- Abstract
This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman's correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute r
partial = 0.13–0.54, p < 0.05; and habitual rpartial = 0.14–0.28, p < 0.01), proanthocyanidins (acute rpartial = 0.24–0.49, p < 0.001; and habitual rpartial = 0.10–0.15, p < 0.05), theaflavins (acute rpartial = 0.22–0.31, p < 0.001; and habitual rpartial = 0.20–0.26, p < 0.01), and total flavan-3-ols (acute rpartial = 0.40–0.48, p < 0.001; and habitual rpartial = 0.23–0.33, p < 0.001). Similarly, urinary concentrations of flavan-3-ols were weakly correlated with both acute (rpartial = 0.12–0.30, p < 0.05) and habitual intake (rpartial = 0.10–0.27, p < 0.05) of apple and pear, stone fruits, berries, chocolate and chocolate products, cakes and pastries, tea, herbal tea, wine, red wine, and beer and cider. Moreover, all comparable correlations were stronger for urinary (-)-epicatechin than for (+)-catechin. In conclusion, our data support the use of urinary concentrations of (+)-catechin and (-)-epicatechin, especially as short-term nutritional biomarkers of dietary catechin, epicatechin and total flavan-3-ol monomers. [ABSTRACT FROM AUTHOR]- Published
- 2021
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31. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study
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Moskal, Aurelie, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Freisling, Heinz, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Nailler, Laura, Wendt, Andrea, Kühn, Tilman, Boeing, Heiner, Buijsse, Brian, Tjønneland, Anne, Halkjær, Jytte, Dahm, Christina C., Chiuve, Stephanie E., Quirós, Jose R., Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Huerta Castaño, José M., Gurrea, Aurelio Barricarte, Khaw, Kay-Tee, Lentjes, Marleen A., Key, Timothy J., Romaguera, Dora, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Beulens, Joline W. J., Ericson, Ulrika, Drake, Isabel, Nilsson, Lena M., Winkvist, Anna, Weiderpass, Elisabete, Hjartåker, Anette, Riboli, Elio, and Slimani, Nadia
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Biology and Life Sciences ,Nutrition ,Nutrients ,Vitamins ,Nutritional Deficiencies ,Micronutrient Deficiencies ,Medicine and Health Sciences ,Epidemiology ,Cancer Epidemiology ,Epidemiological Methods and Statistics ,Public and Occupational Health ,Physical Sciences ,Mathematics ,Statistics (Mathematics) ,Biostatistics ,Confidence Intervals ,Statistical Methods - Abstract
Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.
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- 2014
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32. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition.
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Botteri E, Peveri G, Berstad P, Bagnardi V, Chen SLF, Sandanger TM, Hoff G, Dahm CC, Antoniussen CS, Tjønneland A, Eriksen AK, Skeie G, Perez-Cornago A, Huerta JM, Jakszyn P, Harlid S, Sundström B, Barricarte A, Monninkhof EM, Derksen JWG, Schulze MB, Bueno-de-Mesquita B, Sánchez MJ, Cross AJ, Tsilidis KK, De Magistris MS, Kaaks R, Katzke V, Rothwell JA, Laouali N, Severi G, Amiano P, Contiero P, Sacerdote C, Goldberg M, Touvier M, Freisling H, Viallon V, Weiderpass E, Riboli E, Gunter MJ, Jenab M, and Ferrari P
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- Humans, Risk Factors, Prospective Studies, Nutritional Status, Life Style, Colorectal Neoplasms epidemiology, Colorectal Neoplasms prevention & control
- Abstract
Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort., Methods: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI)., Results: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile., Discussion: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention., (Copyright © 2022 by The American College of Gastroenterology.)
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- 2023
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33. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood.
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Wedekind R, Kiss A, Keski-Rahkonen P, Viallon V, Rothwell JA, Cross AJ, Rostgaard-Hansen AL, Sandanger TM, Jakszyn P, Schmidt JA, Pala V, Vermeulen R, Schulze MB, Kühn T, Johnson T, Trichopoulou A, Peppa E, La Vechia C, Masala G, Tumino R, Sacerdote C, Wittenbecher C, de Magistris MS, Dahm CC, Severi G, Mancini FR, Weiderpass E, Gunter MJ, Huybrechts I, and Scalbert A
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- Adult, Animals, Carnitine blood, Carnitine chemistry, Carnitine urine, Cross-Sectional Studies, Female, Humans, Male, Metabolomics, Prospective Studies, Swine, Carnitine analogs & derivatives, Meat Products analysis
- Abstract
Background: Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited., Objectives: To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort., Methods: In the randomized crossover trial, 12 volunteers successively consumed 2 different diets containing either pork or tofu for 3 d each. A panel of 44 ACs including several oxidized ACs was analyzed by LC-MS in plasma and urine samples collected after the 3-d period. ACs that were associated with pork intake were then measured in urine (n = 474) and serum samples (n = 451) from the European Prospective Investigation into Cancer and nutrition (EPIC) study and tested for associations with habitual red and processed meat intake derived from dietary questionnaires., Results: In urine samples from the intervention study, pork intake was positively associated with concentrations of 18 short- and medium-chain ACs. Eleven of these were also positively associated with habitual red and processed meat intake in the EPIC cross-sectional study. In blood, C18:0 was positively associated with red meat intake in both the intervention study (q = 0.004, Student's t-test) and the cross-sectional study (q = 0.033, linear regression)., Conclusions: AC concentrations in urine and blood were associated with red meat intake in both a highly controlled intervention study and in subjects of a cross-sectional study. Our data on the role of meat intake on this important pathway of fatty acid and energy metabolism may help understanding the role of red meat consumption in the etiology of some chronic diseases. This trial was registered at Clinicaltrials.gov as NCT03354130., (Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.)
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- 2020
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34. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.
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Zheng JS, Sharp SJ, Imamura F, Koulman A, Schulze MB, Ye Z, Griffin J, Guevara M, Huerta JM, Kröger J, Sluijs I, Agudo A, Barricarte A, Boeing H, Colorado-Yohar S, Dow C, Dorronsoro M, Dinesen PT, Fagherazzi G, Franks PW, Feskens EJM, Kühn T, Katzke VA, Key TJ, Khaw KT, de Magistris MS, Mancini FR, Molina-Portillo E, Nilsson PM, Olsen A, Overvad K, Palli D, Quirós JR, Rolandsson O, Ricceri F, Spijkerman AMW, Slimani N, Tagliabue G, Tjonneland A, Tumino R, van der Schouw YT, Langenberg C, Riboli E, Forouhi NG, and Wareham NJ
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- Adult, Aged, Body Mass Index, Cholesterol, HDL, Cholesterol, LDL blood, Cross-Sectional Studies, Dietary Fats metabolism, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Triglycerides blood, Young Adult, Biomarkers blood, Blood Glucose metabolism, Fatty Acids blood, Inflammation blood, Lipids blood
- Abstract
Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways., Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested., Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption., Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.
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- 2017
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35. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.
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Moskal A, Freisling H, Byrnes G, Assi N, Fahey MT, Jenab M, Ferrari P, Tjønneland A, Petersen KE, Dahm CC, Hansen CP, Affret A, Boutron-Ruault MC, Cadeau C, Kühn T, Katzke V, Iqbal K, Boeing H, Trichopoulou A, Bamia C, Naska A, Masala G, de Magistris MS, Sieri S, Tumino R, Sacerdote C, Peeters PH, Bueno-de-Mesquita BH, Engeset D, Licaj I, Skeie G, Ardanaz E, Buckland G, Castaño JM, Quirós JR, Amiano P, Molina-Portillo E, Winkvist A, Myte R, Ericson U, Sonestedt E, Perez-Cornago A, Wareham N, Khaw KT, Huybrechts I, Tsilidis KK, Ward H, Gunter MJ, and Slimani N
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- Adult, Colorectal Neoplasms epidemiology, Europe epidemiology, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Colorectal Neoplasms physiopathology, Nutritional Status
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Background: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study., Methods: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors., Results: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk., Conclusions: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
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- 2016
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36. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
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Assi N, Moskal A, Slimani N, Viallon V, Chajes V, Freisling H, Monni S, Knueppel S, Förster J, Weiderpass E, Lujan-Barroso L, Amiano P, Ardanaz E, Molina-Montes E, Salmerón D, Quirós JR, Olsen A, Tjønneland A, Dahm CC, Overvad K, Dossus L, Fournier A, Baglietto L, Fortner RT, Kaaks R, Trichopoulou A, Bamia C, Orfanos P, De Magistris MS, Masala G, Agnoli C, Ricceri F, Tumino R, Bueno de Mesquita HB, Bakker MF, Peeters PH, Skeie G, Braaten T, Winkvist A, Johansson I, Khaw KT, Wareham NJ, Key T, Travis R, Schmidt JA, Merritt MA, Riboli E, Romieu I, and Ferrari P
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- Adult, Breast Neoplasms etiology, Breast Neoplasms metabolism, Diet Surveys, Europe, Female, Humans, Menopause, Middle Aged, Proportional Hazards Models, Risk Factors, Breast Neoplasms prevention & control, Diet, Feeding Behavior, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism
- Abstract
Objective: Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology., Design: Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison., Setting: The European Prospective Investigation into Cancer and Nutrition (EPIC)., Subjects: Women (n 334 850) from the EPIC study., Results: The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B12 and D, while the second TT component (TC2) reflected a diet rich in β-carotene, riboflavin, thiamin, vitamins C and B6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=0·89, 95 % CI 0·83, 0·95, P trend<0·01) and showed a significantly lower risk in oestrogen receptor-positive (HRQ5 v. Q1=0·89, 95 % CI 0·81, 0·98, P trend=0·02) and progesterone receptor-positive tumours (HRQ5 v. Q1=0·87, 95 % CI 0·77, 0·98, P trend<0·01)., Conclusions: TT produces readily interpretable sparse components explaining similar amounts of variation as principal component analysis. Our results suggest that participants with a nutrient pattern high in micronutrients found in vegetables, fruits and cereals had a lower risk of BC.
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- 2016
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37. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
- Author
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Eussen SJ, Nilsen RM, Midttun Ø, Hustad S, IJssennagger N, Meyer K, Fredriksen Å, Ulvik A, Ueland PM, Brennan P, Johansson M, Bueno-de-Mesquita B, Vineis P, Chuang SC, Boutron-Ruault MC, Dossus L, Perquier F, Overvad K, Teucher B, Grote VA, Trichopoulou A, Adarakis G, Plada M, Sieri S, Tumino R, de Magistris MS, Ros MM, Peeters PH, Redondo ML, Zamora-Ros R, Chirlaque MD, Ardanaz E, Sonestedt E, Ericson U, Schneede J, van Guelpen B, Wark PA, Gallo V, Norat T, Riboli E, and Vollset SE
- Subjects
- Adult, Aged, Alcohol Drinking ethnology, Chronic Disease ethnology, Ethnicity, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Sex Factors, Smoking ethnology, Folic Acid blood, Glycine blood, Health Behavior ethnology, Life Style ethnology, Sarcosine blood, Serine blood, Vitamin B 12 blood
- Abstract
Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10·4 nmol/l; women, 10·7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B₂ concentrations were highest in Northern Europe (men, 22·2 nmol/l; women, 26·0 nmol/l) and decreased towards Southern Europe (P trend< 0·001). Vitamin B(6) concentrations were highest in Central Europe in men (77·3 nmol/l) and highest in the North among women (70·4 nmol/l), with decreasing concentrations towards Southern Europe in women (P trend< 0·001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.
- Published
- 2013
- Full Text
- View/download PDF
38. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
- Author
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Zamora-Ros R, Knaze V, Luján-Barroso L, Romieu I, Scalbert A, Slimani N, Hjartåker A, Engeset D, Skeie G, Overvad K, Bredsdorff L, Tjønneland A, Halkjær J, Key TJ, Khaw KT, Mulligan AA, Winkvist A, Johansson I, Bueno-de-Mesquita HB, Peeters PH, Wallström P, Ericson U, Pala V, de Magistris MS, Polidoro S, Tumino R, Trichopoulou A, Dilis V, Katsoulis M, Huerta JM, Martínez V, Sánchez MJ, Ardanaz E, Amiano P, Teucher B, Grote V, Bendinelli B, Boeing H, Förster J, Touillaud M, Perquier F, Fagherazzi G, Gallo V, Riboli E, and González CA
- Subjects
- Adult, Aged, Diet, Mediterranean, Europe, Female, Food Analysis, Fruit, Humans, Male, Mediterranean Region, Middle Aged, Tea, Wine, Diet, Flavonoids classification
- Abstract
A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35,628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft®). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373·7 mg/d) and MED countries (370·2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48·2%) and flavan-3-ol monomers (24·9%) and the principal food sources were tea (25·7%) and fruits (32·8%). In the MED region, proanthocyanidins (59·0%) were by far the most abundant contributor and fruits (55·1%), wines (16·7%) and tea (6·8%) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.
- Published
- 2013
- Full Text
- View/download PDF
39. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort.
- Author
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Zamora-Ros R, Knaze V, Luján-Barroso L, Slimani N, Romieu I, Fedirko V, de Magistris MS, Ericson U, Amiano P, Trichopoulou A, Dilis V, Naska A, Engeset D, Skeie G, Cassidy A, Overvad K, Peeters PH, Huerta JM, Sánchez MJ, Quirós JR, Sacerdote C, Grioni S, Tumino R, Johansson G, Johansson I, Drake I, Crowe FL, Barricarte A, Kaaks R, Teucher B, Bueno-de-Mesquita HB, van Rossum CT, Norat T, Romaguera D, Vergnaud AC, Tjønneland A, Halkjær J, Clavel-Chapelon F, Boutron-Ruault MC, Touillaud M, Salvini S, Khaw KT, Wareham N, Boeing H, Förster J, Riboli E, and González CA
- Subjects
- Adult, Aged, Cohort Studies, Databases, Factual, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Diet Records, Eating, Flavanones administration & dosage, Flavones administration & dosage, Flavonols administration & dosage
- Abstract
Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their food sources for 36 037 subjects, aged between 35 and 74 years, in twenty-seven study centres were obtained using standardised 24 h dietary recall software (EPIC-SOFT). An ad hoc food composition database on FLAV was compiled using data from US Department of Agriculture and Phenol-Explorer databases and was expanded using recipes, estimations and flavonoid retention factors in order to increase its correspondence with the 24 h dietary recall. Our results showed that the highest FLAV-consuming centre was the UK health-conscious group, with 130·9 and 97·0 mg/d for men and women, respectively. The lowest FLAV intakes were 36·8 mg/d in men from Umeå and 37·2 mg/d in women from Malmö (Sweden). The flavanone sub-class was the main contributor to the total FLAV intake ranging from 46·6 to 52·9 % depending on the region. Flavonols ranged from 38·5 to 47·3 % and flavones from 5·8 to 8·6 %. FLAV intake was higher in women, non-smokers, increased with level of education and physical activity. The major food sources were citrus fruits and citrus-based juices (especially for flavanones), tea, wine, other fruits and some vegetables. We concluded that the present study shows heterogeneity in intake of these three sub-classes of flavonoids across European regions and highlights differences by sex and other sociodemographic and lifestyle factors.
- Published
- 2011
- Full Text
- View/download PDF
40. Ecological-level associations between highly processed food intakes and plasma phospholipid elaidic acid concentrations: results from a cross-sectional study within the European prospective investigation into cancer and nutrition (EPIC).
- Author
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Chajès V, Biessy C, Byrnes G, Deharveng G, Saadatian-Elahi M, Jenab M, Peeters PH, Ocké M, Bueno-de-Mesquita HB, Johansson I, Hallmans G, Manjer J, Wirfält E, Jakszyn P, González CA, Huerta JM, Martinez C, Amiano P, Suárez LR, Ardanaz E, Tjønneland A, Halkjaer J, Overvad K, Jakobsen MU, Berrino F, Pala V, Palli D, Tumino R, Vineis P, de Magistris MS, Spencer EA, Crowe FL, Bingham S, Khaw KT, Linseisen J, Rohrmann S, Boeing H, Nöethlings U, Olsen KS, Skeie G, Lund E, Trichopoulou A, Zilis D, Oustoglou E, Clavel-Chapelon F, Riboli E, and Slimani N
- Subjects
- Cohort Studies, Cross-Sectional Studies, Dietary Fats administration & dosage, Dietary Fats blood, Europe, Fatty Acids administration & dosage, Fatty Acids blood, Female, Food Handling methods, Humans, Interviews as Topic, Male, Middle Aged, Multivariate Analysis, Neoplasms pathology, Nutrition Surveys, Oleic Acids, Surveys and Questionnaires, Energy Intake, Fast Foods, Feeding Behavior, Oleic Acid blood, Phospholipids blood
- Abstract
Elaidic acid is the main unnatural trans fatty acid isomer occurring during partial hydrogenation of vegetable oils used as ingredients for the formulation of processed foods. The main objective is to assess associations between processed food intakes and plasma phospholipid elaidic acid concentrations within the European Prospective Investigation into Cancer and Nutrition study. A cross-sectional study was used to determine fatty acid profiles in 3,003 subjects from 16 centers. Single 24-h dietary recalls (24-HDR) were collected using a standardized computerized interview program. Food intakes were computed according to their degree of processing (moderately/nonprocessed foods, processed staple foods, highly processed foods). Adjusted ecological and individual correlations were calculated between processed food intakes and plasma elaidic acid levels. At the population level, mean intakes of highly processed foods were strongly correlated with mean levels of plasma elaidic acid in men (P = 0.0016) and in women (P = 0.0012). At the individual level, these associations remained but at a much lower level in men (r = 0.08, P = 0.006) and in women (r = 0.09, P = 0.0001). The use of an averaged 24-HDR measure of highly processed food intakes is adequate for predicting mean levels of plasma elaidic acid among European populations.
- Published
- 2011
- Full Text
- View/download PDF
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