19 results on '"Dawn E. Jaroszewski"'
Search Results
2. Acute Toxicities and Short-Term Patient Outcomes After Intensity-Modulated Proton Beam Radiation Therapy or Intensity-Modulated Photon Radiation Therapy for Esophageal Carcinoma: A Mayo Clinic Experience
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Ronik S. Bhangoo, MD, Todd A. DeWees, PhD, Nathan Y. Yu, MD, Julia X. Ding, BA, Chenbin Liu, PhD, Michael A. Golafshar, MS, William G. Rule, MD, Sujay A. Vora, MD, Helen J. Ross, MD, Daniel H. Ahn, DO, Staci E. Beamer, MD, Dawn E. Jaroszewski, MD, Christopher L. Hallemeier, MD, Wei Liu, PhD, Jonathan B. Ashman, MD, PhD, and Terence T. Sio, MD, MS
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: Intensity modulated proton beam radiation therapy (IMPT) has a clinically significant dosimetric advantage over intensity modulated photon radiation therapy (IMRT) for the treatment of patients with esophageal cancer, particularly for sparing the heart and lungs. We compared acute radiation therapy–related toxicities and short-term clinical outcomes of patients with esophageal cancer who received treatment with IMPT or IMRT. Methods and Materials: We retrospectively reviewed the electronic health records of consecutive adult patients with esophageal cancer who underwent concurrent chemoradiotherapy with IMPT or IMRT in the definitive or neoadjuvant setting from January 1, 2014, through June 30, 2018, with additional follow-up data collected through January 31, 2019. Treatment-related toxicities were evaluated per the Common Terminology Criteria for Adverse Events, version 4. Survival outcomes were estimated with the Kaplan-Meier method. Results: A total of 64 patients (32 per group) were included (median follow-up time: 10 months for IMPT patients vs 14 months for IMRT patients). The most common radiation therapy regimen was 45 Gy in 25 fractions, and 80% of patients received a simultaneous integrated boost to a median cumulative dose of 50 Gy. Similar numbers of IMPT patients (n = 15; 47%) and IMRT patients (n = 18; 56%) underwent surgery (P = .07), with no difference in pathologic complete response rates (IMPT: n = 5; 33% vs IMRT: n = 7; 39%; P = .14). At 1 year, the clinical outcomes also were similar for IMPT and IMRT patients, respectively. Local control was 92% versus 84% (P = .87), locoregional control 92% versus 80% (P = .76), distant metastasis–free survival 87% versus 65% (P = .08), progression-free survival 71% versus 45% (P = .15), and overall survival 74% versus 71% (P = .62). The rate of acute treatment–related grade 3 toxicity was similar between the groups (P = .71). Conclusions: In our early experience, IMPT is a safe and effective treatment when administered as part of definitive or trimodality therapy. Longer follow-up is required to evaluate the effectiveness of IMPT.
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- 2020
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3. Early Outcomes of Patients With Locally Advanced Non-small Cell Lung Cancer Treated With Intensity-Modulated Proton Therapy Versus Intensity-Modulated Radiation Therapy: The Mayo Clinic Experience
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Nathan Y. Yu, MD, Todd A. DeWees, PhD, Chenbin Liu, PhD, Thomas B. Daniels, MD, Jonathan B. Ashman, MD, PhD, Staci E. Beamer, MD, Dawn E. Jaroszewski, MD, Helen J. Ross, MD, Harshita R. Paripati, MD, Jean-Claude M. Rwigema, MD, Julia X. Ding, Jie Shan, MS, Wei Liu, PhD, Steven E. Schild, MD, and Terence T. Sio, MD, MS
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: There are very little data available comparing outcomes of intensity-modulated proton therapy (IMPT) to intensity-modulated radiation therapy (IMRT) in patients with locally advanced NSCLC (LA-NSCLC). Methods: Seventy-nine consecutively treated patients with LA-NSCLC underwent definitive IMPT (n = 33 [42%]) or IMRT (n = 46 [58%]) from 2016 to 2018 at our institution. Survival rates were calculated using the Kaplan-Meier method and compared with the log-rank test. Acute and subacute toxicities were graded based on Common Terminology Criteria for Adverse Events, version 4.03. Results: Median follow-up was 10.5 months (range, 1-27) for all surviving patients. Most were stage III (80%), received median radiation therapy (RT) dose of 60 Gy (range, 45-72), and had concurrent chemotherapy (65%). At baseline, the IMPT cohort was older (76 vs 69 years, P
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- 2020
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4. Cardiopulmonary Outcomes After the Nuss Procedure in Pectus Excavatum
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Dawn E. Jaroszewski, Juan M. Farina, Michael B. Gotway, Joshua D. Stearns, Michelle A. Peterson, Venkata S. K. K. Pulivarthi, Peter Bostoros, Ahmad S. Abdelrazek, Ashwini Gotimukul, David S. Majdalany, Courtney M. Wheatley‐Guy, and Reza Arsanjani
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cardiothoracic surgery ,echocardiography ,exercise testing ,pectus excavatum ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Pectus excavatum is the most common chest wall deformity. There is still controversy about cardiopulmonary limitations of this disease and benefits of surgical repair. This study evaluates the impact of pectus excavatum on the cardiopulmonary function of adult patients before and after a modified minimally invasive repair. Methods and Results In this retrospective cohort study, an electronic database was used to identify consecutive adult (aged ≥18 years) patients who underwent cardiopulmonary exercise testing before and after primary pectus excavatum repair at Mayo Clinic Arizona from 2011 to 2020. In total, 392 patients underwent preoperative cardiopulmonary exercise testing; abnormal oxygen consumption results were present in 68% of patients. Among them, 130 patients (68% men, mean age, 32.4±10.0 years) had post‐repair evaluations. Post‐repair tests were performed immediately before bar removal with a mean time between repair and post‐repair testing of 3.4±0.7 years (range, 2.5–7.0). A significant improvement in cardiopulmonary outcomes (P
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- 2022
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5. Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers
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Mitesh J. Borad, Jan B. Egan, Rachel M. Condjella, Winnie S. Liang, Rafael Fonseca, Nicole R. Ritacca, Ann E. McCullough, Michael T. Barrett, Katherine S. Hunt, Mia D. Champion, Maitray D. Patel, Scott W. Young, Alvin C. Silva, Thai H. Ho, Thorvardur R. Halfdanarson, Robert R. McWilliams, Konstantinos N. Lazaridis, Ramesh K. Ramanathan, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D. Mastrian, Riccardo Valdez, Dawn E. Jaroszewski, Daniel D. Von Hoff, David W. Craig, A. Keith Stewart, John D. Carpten, and Alan H. Bryce
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Medicine ,Science - Abstract
Abstract DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic target prioritisation, novel target discovery/application and comprehensive germline assessment. A prospective study in 35 advanced/refractory cancer patients was conducted using CLIA-compliant IGP. Feasibility was assessed by estimating time to results (TTR), prioritising/assigning putative therapeutic targets, assessing drug access, ascertaining germline alterations, and assessing patient preferences/perspectives on data use/reporting. Therapeutic targets were identified using biointelligence/pathway analyses and interpreted by a Genomic Tumour Board. Seventy-five percent of cases harboured 1–3 therapeutically targetable mutations/case (median 79 mutations of potential functional significance/case). Median time to CLIA-validated results was 116 days with CLIA-validation of targets achieved in 21/22 patients. IGP directed treatment was instituted in 13 patients utilising on/off label FDA approved drugs (n = 9), clinical trials (n = 3) and single patient IND (n = 1). Preliminary clinical efficacy was noted in five patients (two partial response, three stable disease). Although barriers to broader application exist, including the need for wider availability of therapies, IGP in a CLIA-framework is feasible and valuable in selection/prioritisation of anti-cancer therapeutic targets.
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- 2016
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6. Long-term follow-up of minimally invasive video-assisted thoracoscopic surgery with epicardial radiofrequency ablation for complex cases of inappropriate sinus tachycardia
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J. William Schleifer, MD, Dawn E. Jaroszewski, MD, Nilay Shah, MD, and Luis R. Scott, MD, FHRS
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Epicardial ,Inappropriate sinus tachycardia ,Minimally invasive surgery ,Pacing ,Radiofrequency ablation ,Sinus node modification ,Video-assisted thoracoscopic surgery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2015
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7. Antibody-Mediated Rejection in Heart Transplantation: Case Presentation with a Review of Current International Guidelines
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Octavio E. Pajaro, Dawn E. Jaroszewski, Robert L. Scott, Anantharam V. Kalya, Henry D. Tazelaar, and Francisco A. Arabia
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Surgery ,RD1-811 - Abstract
Antibody-mediated rejection (AMR) (humoral rejection) of cardiac allografts remains difficult to diagnose and treat. Interest in AMR of cardiac allografts has increased over the last decade as it has become apparent that untreated humoral rejection threatens graft and patient survival. An international and multidisciplinary consensus group has formulated guidelines for the diagnosis and treatment of AMR and established that identification of circulating or donor-specific antibodies is not required and that asymptomatic AMR, that is, biopsy-proven AMR without cardiac dysfunction is a real entity with worsened prognosis. Strict criteria for the diagnosis of cardiac AMR have not been firmly established, although the diagnosis relies heavily on tissue pathological findings. Therapy remains largely empirical. We review an unfortunate experience with one of our patients and summarize recommended criteria for the diagnosis of AMR and potential treatment schemes with a focus on current limitations and the need for future research and innovation.
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- 2011
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8. Successful treatment of visceral pseudoaneurysm after pancreatectomy using flow-diverting stent device
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Rahmi Oklu, Dawn E. Jaroszewski, Amit K. Mathur, Emmanouil Giorgakis, Grace Knuttinen, and Brian W. Chong
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medicine.medical_specialty ,Flow diverter therapy ,business.industry ,medicine.medical_treatment ,Case Report ,Gastroepiploic Artery ,medicine.disease ,Post-pancreatectomy pseudoaneurysm ,Right gastroepiploic artery ,Surgery ,Pseudoaneurysm ,Electrical conduit ,Esophagectomy ,Flow diverting stent ,medicine.artery ,Pancreatectomy ,Occlusion ,Endovascular repair visceral aneurysm ,medicine ,cardiovascular system ,General Materials Science ,cardiovascular diseases ,business ,human activities ,Gastroepiploic artery pseudoaneurysm - Abstract
Aim of the study is the description of the successful management of gastroepiploic artery pseudoaneurysm with preservation of parent vessels using flow-diversion technology. The present report describes the application of a flow-diversion Pipeline™ Flex device for occlusion of a sidewall bleeding pseudoaneurysm on a patient who was status-post sub-total pancreatectomy and remote esophagectomy with a gastric conduit. The pseudoaneurysm was on the solitary vessel supplying the patient's conduit. Use of flow diversion technology excluded the sidewall pseudoaneurysm while maintaining gastric conduit perfusion. In our case, the application of flow diversion technology allowed the preservation of patency of the main arterial supply to the gastric conduit on a post-esophagectomy patient; loss of the right gastroepiploic artery in that case would had been otherwise catastrophic. Flow-diversion technology can be considered for the treatment of pseudoaneurysms post-pancreatic resections, especially when there is no other surgical or endovascular treatment option.
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- 2020
9. Metastatic Fibrolamellar Hepatocellular Carcinoma to the Pancreas
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Thomas Byrne, Nicolas A. Villa, Douglas O. Faigel, Ramesh K. Ramanathan, Rahul Pannala, Thomas K. Lidner, Danielle J. Haakinson, Dawn E. Jaroszewski, and Nitin Katariya
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medicine.medical_specialty ,medicine.medical_treatment ,Population ,Liver transplantation ,Gastroenterology ,Metastasis ,Liver disease ,Internal medicine ,medicine ,lcsh:RC799-869 ,education ,education.field_of_study ,Lung ,business.industry ,Fibrolamellar hepatocellular carcinoma ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Hepatocellular carcinoma ,lcsh:Diseases of the digestive system. Gastroenterology ,Published online: July, 2015 ,business ,Pancreas - Abstract
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of hepatocellular carcinoma, usually presenting in the younger population (
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- 2015
10. Pectus excavatum repair after sternotomy:the Chest Wall International Group experience with substernal Nuss bars
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Hans K. Pilegaard, Li Yang, Dawn E. Jaroszewski, Andre Hebra, Frazier W. Frantz, Mustafa Yüksel, José Ribas Milanez de Campos, J.Duncan Phillips, Michele Torre, Sadashige Uemura, Chih-Chun Chu, Lisa E. McMahon, Hyung Joo Park, Shuai Li, Antonio Messineo, Frank-Martin Haecker, Robert J. Obermeyer, Shao-tao Tang, Robert E. Kelly, David M. Notrica, and Paul J Gustin
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Male ,Reoperation ,Pulmonary and Respiratory Medicine ,Sternum ,medicine.medical_specialty ,Heart Diseases ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Pectus excavatum ,Interquartile range ,law ,Thoracoscopy ,Cardiopulmonary bypass ,Journal Article ,Humans ,Medicine ,Thoracoplasty ,Cardiac Surgical Procedures ,Child ,Thoracic Wall ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Prostheses and Implants ,General Medicine ,medicine.disease ,Sternotomy ,Cardiac surgery ,Surgery ,Treatment Outcome ,030228 respiratory system ,Median sternotomy ,Funnel Chest ,Female ,Haller index ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES: Patients with pectus excavatum (PE) after prior sternotomy for cardiac surgery present unique challenges for repair of PE. Open repairs have been recommended because of concerns about sternal adhesions and cardiac injury. We report a multi-institutional experience with repair utilizing substernal Nuss bars in this patient population.METHODS: Surgeons from the Chest Wall International Group were queried for experience and retrospective data on PE repair using sub-sternal Nuss bars in patients with a history of median sternotomy for cardiac surgery (November 2000 to August 2015). A descriptive analysis was performed.RESULTS: Data for 75 patients were available from 14 centres. The median age at PE repair was 9.5 years (interquartile range 10.9), and the median Haller index was 3.9 (interquartile range 1.43); 56% of the patients were men. The median time to PE repair was 6.4 years (interquartile range 7.886) after prior cardiac surgery. Twelve patients (16%) required resternotomy before support bar placement: 7 pre-emptively and 5 emergently. Sternal elevation before bar placement was used in 34 patients (45%) and thoracoscopy in 67 patients (89%). Standby with cardiopulmonary bypass was available at 9 centres (64%). Inadvertent cardiac injury occurred in 5 cases (7%) without mortality.CONCLUSIONS: Over a broad range of institutions, substernal Nuss bars were used in PE repair for patients with a history of sternotomy for cardiac surgery. Several technique modifications were reported and may have facilitated repair. Cardiac injury occurred in 7% of cases, and appropriate resources should be available in the event of complications. Prophylactic resternotomy was reported at a minority of centres.
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- 2017
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11. Nuss procedure for repair of pectus excavatum after failed Ravitch procedure in adults: indications and caveats
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MennatAllah M. Ewais, Dawn E. Jaroszewski, Ralph A. Schmid, Gregor J. Kocher, and Nathalie Gstrein
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Exercise intolerance ,030204 cardiovascular system & hematology ,Chest pain ,Nuss procedure ,University hospital ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Pectus excavatum ,medicine ,Deformity ,Haller index ,Original Article ,Major complication ,medicine.symptom ,610 Medicine & health ,business - Abstract
BACKGROUND Recurrence of pectus excavatum (PE) is not an uncommon problem after open repair using the Ravitch technique. The optimal approach for redo surgery is still under debate, especially in adults with less chest wall pliability. Aim of this study was to investigate the usefulness and efficacy of the minimally invasive Nuss technique for repair of recurrent PE after conventional open repair. METHODS We performed a retrospective multicentre review of 20 adult patients from University Hospital Bern (n=6) and the US Mayo Clinic (n=14) who underwent minimally invasive repair of recurrent PE after unsuccessful prior Ravitch procedure. RESULTS Mean patient age at primary open correction was 21 years, with recurrence being evident after a mean duration of 10.5 years (range, 0.25-47 years). Mean age at redo surgery using the Nuss technique was 31 years, with a mean Haller index of 4.7 before and 2.5 after final correction. Main reason for redo surgery was recurrent or persistent deformity (100%), followed by chest pain (75%) and exercise intolerance (75%). No major intraoperative or postoperative complications occurred and successful correction was possible in all patients. CONCLUSIONS Although the procedure itself is more challenging, the minimally invasive Nuss technique can be safely and successfully used for repair of recurrent PE after failed open surgery. In our series final results were good to excellent in the majority of patients without major complications or recurrence.
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- 2016
12. Blunt trauma as a suspected cause of delayed constrictive pericarditis: a case report
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Eric Anderson, Dawn E. Jaroszewski, and Francisco A. Arabia
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Constrictive pericarditis ,Medicine(all) ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,lcsh:R ,lcsh:Medicine ,Case Report ,General Medicine ,medicine.disease ,Surgery ,Coronary artery disease ,Pericarditis ,medicine.anatomical_structure ,Blunt ,Blunt trauma ,medicine ,Pericardium ,Outpatient clinic ,business ,Pericardiectomy - Abstract
Introduction Constrictive pericarditis is a heterogeneous disease with many causes. Traumatic hemopericardium is an uncommon initiating cause. We report the case of a man developing constrictive pericarditis after blunt chest trauma, in order to highlight an approach to diagnosing the condition and to raise awareness of the possibility of this condition developing after blunt trauma. Case presentation A 72-year-old Caucasian man presented initially to our outpatient clinic with a one-year history of progressively worsening dyspnea, and recent onset of edema of the legs. He was later taken to the emergency department and admitted to hospital. He had previously received unsuccessful treatment from his local primary physicians for suspected respiratory disorder and cellulitis of his legs. Echocardiography showed evidence of pericardial constriction, and computed tomography revealed nodular, lobulated thickening of the pericardium and pleura bilaterally. Interventional biopsies were taken, but gave inconclusive results. Thus, as pericarditis and/or advanced malignancy were suspected, diagnostic video-assisted thoracoscopic surgery was performed to take biopsies from the abnormal lung and pericardial tissue. Examination of these supported the diagnosis of pericarditis, as acute and chronic inflammation and fibrous thickening were found, with no evidence of malignancy. Our patient underwent cardiac catheterization, which revealed three-vessel coronary artery disease. Emergency total pericardiectomy and coronary bypass were performed. Having excluded other common initiating factors, we considered that a blunt trauma that our patient had previously sustained to his chest was the potential cause of the constrictive pericarditis. Conclusion This was an interesting case of blunt chest trauma followed by progressive pericardial and pleural thickening. Subsequent development of chronic constrictive pericarditis occurred, requiring treatment by surgical pericardiectomy, as the clinical course of constrictive pericarditis is usually progressive without surgical intervention. Diagnosis of constrictive pericarditis remains challenging. Although uncommon, blunt trauma should be considered as a possible initiating cause. Delayed presentation of constrictive pericarditis should also be considered as a possible morbidity in a patient who has sustained blunt chest trauma. Our case also highlights the importance of performing echocardiography promptly in patients experiencing ongoing symptoms of congestive heart failure to allow earlier diagnosis of constrictive pericarditis or other cardiac disorders, and avoid unnecessary treatments.
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- 2011
13. Antibody-Mediated Rejection in Heart Transplantation: Case Presentation with a Review of Current International Guidelines
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Dawn E. Jaroszewski, Henry D. Tazelaar, Octavio E. Pajaro, Robert L. Scott, Francisco A. Arabia, and Anantharam Kalya
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Heart transplantation ,medicine.medical_specialty ,Pathology ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,Patient survival ,Case presentation ,Review Article ,lcsh:RD1-811 ,Asymptomatic ,Cardiac dysfunction ,Antibody mediated rejection ,Medicine ,medicine.symptom ,business ,Intensive care medicine - Abstract
Antibody-mediated rejection (AMR) (humoral rejection) of cardiac allografts remains difficult to diagnose and treat. Interest in AMR of cardiac allografts has increased over the last decade as it has become apparent that untreated humoral rejection threatens graft and patient survival. An international and multidisciplinary consensus group has formulated guidelines for the diagnosis and treatment of AMR and established that identification of circulating or donor-specific antibodies is not required and that asymptomatic AMR, that is, biopsy-proven AMR without cardiac dysfunction is a real entity with worsened prognosis. Strict criteria for the diagnosis of cardiac AMR have not been firmly established, although the diagnosis relies heavily on tissue pathological findings. Therapy remains largely empirical. We review an unfortunate experience with one of our patients and summarize recommended criteria for the diagnosis of AMR and potential treatment schemes with a focus on current limitations and the need for future research and innovation.
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- 2011
14. Acute respiratory distress secondary to posterior mediastinal goiter: a case report
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Dawn E. Jaroszewski, Faisal G. Bakaeen, and Joseph Huh
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Medicine(all) ,Mediastinal goiter ,medicine.medical_specialty ,Pathology ,endocrine system ,Goiter ,endocrine system diseases ,business.industry ,General Medicine ,Acute respiratory distress ,medicine.disease ,eye diseases ,Case report ,medicine ,TRACHEAL COMPRESSION ,Radiology ,Respiratory system ,business - Abstract
Large posterior mediastinal goiters are extremely rare. Progressive enlargement and possible compression of adjacent structures, as well as malignant potential necessitate that these goiters should be surgically excised. A review of mediastinal tumors, specifically intra-thoracic goiters is presented along with a case report of acute respiratory compromise secondary to tracheal compression by a large posterior goiter.
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- 2009
15. Posterior lung herniation after a coughing spell: a case report
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Faisal G. Bakaeen, Kenneth M Jastrow, Danny Chu, Dawn E. Jaroszewski, and Joseph Huh
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Medicine(all) ,medicine.medical_specialty ,Pediatrics ,Posterior chest wall ,Lung ,business.industry ,Lung hernia ,Case Report ,General Medicine ,respiratory system ,Surgery ,respiratory tract diseases ,stomatognathic diseases ,medicine.anatomical_structure ,surgical procedures, operative ,medicine ,business ,External intercostal muscles ,Intercostal muscle - Abstract
Lung hernias are rare, occurring most commonly after trauma or surgery. Spontaneous lung hernias are even rarer and have only been reported as occurring anteriorly. We present a 72-year-old male who developed a spontaneous posterior lung hernia after a severe coughing episode. We describe the evaluation and surgical management of this unusual condition and provide a brief review of the literature.
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- 2009
16. Utility of detailed preoperative cardiac testing and incidence of post-thoracotomy myocardial infarction
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Dawn E. Jaroszewski, Danny Chu, S. Chris Malaisrie, Faisal G. Bakaeen, Anthony D. Riffel, Howard S. Gordon, Joseph Huh, and Xing Li Wang
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Male ,Cardiac Catheterization ,Lung Neoplasms ,medicine.medical_treatment ,Myocardial Infarction ,Myocardial Ischemia ,Coronary Angiography ,Cohort Studies ,Coronary artery disease ,Postoperative Complications ,Thoracotomy ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Aged, 80 and over ,Incidence ,Middle Aged ,Thrombosis ,Heart Function Tests ,Cardiology ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,Echocardiography, Stress ,Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Revascularization ,Risk Assessment ,Age Distribution ,Internal medicine ,Angioplasty ,Preoperative Care ,Coronary stent ,medicine ,Humans ,Sex Distribution ,Aged ,Neoplasm Staging ,Probability ,Retrospective Studies ,business.industry ,medicine.disease ,Survival Analysis ,Surgery ,Multivariate Analysis ,Myocardial infarction diagnosis ,business ,Follow-Up Studies - Abstract
Objective Recent literature has questioned the efficacy of routine detailed preoperative cardiac ischemia testing and preoperative cardiac intervention before noncardiac surgical procedures. Methods We performed a retrospective review of patients undergoing thoracotomy (n = 294) between January of 1999 and January of 2005. Results The median age was 62 years. Detailed preoperative cardiac testing was performed on 184 patients (63%) and went beyond a thorough history, physical examination, and electrocardiogram to include at least one of the following: dobutamine stress echo (n = 116), nuclear stress test (n = 66), treadmill test (n = 8), and coronary angiogram (n = 40). Evidence for coronary disease was detected in 43% of tests (99/230) performed. Revascularization was performed in 10% of all patients (4/40) who underwent coronary angiography. Postoperative myocardial infarction occurred in 7 patients (2.4%) with 4 myocardial infarction-related mortalities. No significant difference was found in the incidence of myocardial infarction in patients with (n = 184) or without (n = 110) detailed preoperative cardiac testing (3.3% vs 0.9%, P = .29). Of the 4 patients (1.4%) who underwent revascularization to treat coronary lesions identified during prethoracotomy workup, 2 had a myocardial infarction, 1 of which was caused by thrombosis of a coronary stent. In the subset of patients who underwent lobectomy (n = 149), detailed cardiac testing was performed on 107 patients (72%). The incidence of myocardial infarction was similar in tested and untested patients (2.8% vs 2.4% respectively, P = 1.0). Conclusion Selective use of detailed preoperative cardiac testing refines risk stratification and identifies patients for corrective cardiac interventions; however, it did not prove fully protective against myocardial infarction after thoracotomy in our study.
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17. Descending aortic replacement after Nuss for pectus excavatum in a Marfan patient—Case report
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Michael B. Gotway, D. Craig Miller, Patrick A. DeValeria, MennatAllah M. Ewais, and Dawn E. Jaroszewski
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Marfan syndrome ,musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Future risk ,Case Report ,Nuss procedure ,03 medical and health sciences ,0302 clinical medicine ,Pectus excavatum ,Internal medicine ,medicine.artery ,Medicine ,cardiovascular diseases ,skin and connective tissue diseases ,Aortic dilation ,business.industry ,Descending aorta ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,cardiovascular system ,Cardiology ,business ,030217 neurology & neurosurgery - Abstract
IntroductionThe Nuss procedure for pectus excavatum (PE) repair has been successfully performed in Marfan syndrome (MFS) patients however there is concern for future risk of aortic dilation/rupture and need for emergent access with support bars in place.Case presentationWe present a 45 year-old male with MFS that required descending aortic replacement shortly after modified Nuss repair.DiscussionThe majority of MFS patients have severe PE and repair with the Nuss procedure is not uncommon. The risk for life threatening aortic dilation, dissection, or rupture in such patients is a concern when utilizing this technique. Our work has been reported in line with the CARE criteria.ConclusionNuss repair should be considered in MFS patients with technique modifications and careful consideration of future risk of aortic dilation and rupture.
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18. Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient
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Halyard Health and Dawn E. Jaroszewski, Associate Professor of Surgery
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- 2017
19. Giant hibernoma of the thoracic pleura and chest wall.
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Jaroszewski DE and Petris GD
- Abstract
Hibernoma is a rare tumor containing prominent brown adipocytes that resemble normal brown fat. Brown fat (versus white fat) is predominantly found in hibernating mammals and infants. Brown fat adipocytes contain a higher number of small lipid droplets and a much denser concentration of mitochondria. The tumor can occur in a variety of locations however the extremities, followed by the head and neck, have been the most common sights. All variants of hibernoma described have followed a benign course with the majority presenting as a small, lobulated, nontender lesions. We present a case of a giant hibernoma arising from the pleura which invaded the intra and extra-thoracic chest.
- Published
- 2013
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