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20. The prognostic significance of atrial fibrillation in heart failure with preserved ejection function: insights from KaRen, a prospective and multicenter study

Author

Bosseau, Christian, Donal, Erwan, Lund, Lars H., Oger, Emmanuel, Hage, Camilla, Mulak, Geneviève, Daubert, Jean-Claude, Linde, Cecilia, Donal, Erwan, Lund, Lars H., Leclercq, Christophe, de Groote, Pascal, Ennezat, Pierre-Vladimir, Lafitte, Stéphane, Réant, Patricia, Bauer, Fabrice, Derumeaux, Geneviève, Bergerot, Cyrille, de Place, Christian, Juillière, Yves, Selton-Suty, Christine, Logeart, Damien, Gueret, Pascal, Lim, Pascal, Trochu, Jean-Noël, Pirou, Nicolas, Habib, Gilbert, Tournoux, François, Haugen-Löfman, Ida, Edner, Magnus, Emtell, Hans, and On behalf of the KaRen investigators

Published
2017
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23. Long‐term outcomes in heart failure with preserved ejection fraction: Predictors of cardiac and non‐cardiac mortality.

Author

Shahim, Angiza, Hourqueig, Marion, Lund, Lars H., Savarese, Gianluigi, Oger, Emmanuel, Venkateshvaran, Ashwin, Benson, Lina, Daubert, Jean‐Claude, Linde, Cecilia, Donal, Erwan, and Hage, Camilla

Subjects
HEART failure, BRAIN natriuretic factor, VENTRICULAR ejection fraction, CORONARY artery disease, BODY mass index
Abstract

Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with cardiovascular (CV) and non‐CV events, but long‐term risk is poorly studied. We assessed incidence and predictors of the long‐term CV and non‐CV events. Methods and results: Patients presenting with acute HF, EF ≥ 45%, and N‐terminal pro‐brain natriuretic peptide > 300 ng/L were enrolled in the Karolinska‐Rennes study in 2007–11 and were reassessed after 4–8 weeks in a stable state. Long‐term follow‐up was conducted in 2018. The Fine–Gray sub‐distribution hazard regression was used to detect predictors of CV and non‐CV deaths, investigated separately from baseline acute presentation (demographic data only) and from the 4–8 week outpatient visit (including echocardiographic data). Of 539 patients enrolled [median age 78 (interquartile range: 72–84) years; 52% female], 397 patients were available for the long‐term follow‐up. Over a median follow‐up time from acute presentation of 5.4 (2.1–7.9) years, 269 (68%) patients died, 128 (47%) from CV and 120 (45%) from non‐CV causes. Incidence rates per 1000 patient‐years were 62 [95% confidence interval (CI) 52–74] for CV and 58 (95% CI 48–69) for non‐CV death. Higher age and coronary artery disease (CAD) were independent predictors of CV death, and anaemia, stroke, kidney disease, and lower body mass index (BMI) and sodium concentrations of non‐CV death. From the stable 4–8 week visit, anaemia, CAD, and tricuspid regurgitation (>3.1 m/s) were independent predictors of CV death, and higher age of non‐CV death. Conclusions: In patients with acute decompensated HFpEF, over 5 years of follow‐up, nearly two‐thirds of patients died, half from CV and the other half from non‐CV causes. CAD and tricuspid regurgitation were associated with CV death. Stroke, kidney disease, lower BMI, and lower sodium were associated with non‐CV death. Anaemia and higher age were associated with both outcomes. [Correction added on 24 March 2023, after first online publication: In the first sentence of the Conclusions, 'two‐thirds' has been inserted before 'of patients died...' in this version.] [ABSTRACT FROM AUTHOR]

Published
2023
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24. The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual-patient-data meta-analysis of COMPANION and CARE-HF

Author

Cleland, John G.F., Bristow, Michael R., Freemantle, Nicholas, Olshansk, Brian, Gras, Daniel, Saxon, Leslie, Tavazzi, Luigi, Boehmer, John, Ghio, Stefano, Feldman, Arthur M., Daubert, Jean-Claude, and deMets, David

Abstract

Background: \ud Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm.\ud \ud Objectives: \ud To identify patient-characteristics that predict the effect, specifically, of CRT-pacemakers (CRT-P) on all-cause mortality or the composite of hospitalisation for heart failure or all-cause mortality.\ud \ud Methods: \ud An individual patient-data meta-analysis of the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) and Cardiac Resynchronization – Heart Failure (CARE-HF) trials. Only patients assigned to CRT-P or control (n = 1738) were included in order to avoid confounding from concomitant defibrillator therapy. The influence of baseline characteristics on treatment effects was investigated.\ud \ud Results: \ud Median age was 67 (59–73) years, most patients were men (70%), 68% had a QRS duration of 150-199 ms and 80% had left bundle branch block (LBBB). Patients assigned to CRT-P had lower rates for all-cause mortality (HR 0.68 (95% CI 0.56 to 0.81; p

Published
2022

26. Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study

Author

Marijon, Eloi, Leclercq, Christophe, Narayanan, Kumar, Boveda, Serge, Klug, Didier, Lacaze-Gadonneix, Jonathan, Defaye, Pascal, Jacob, Sophie, Piot, Olivier, Deharo, Jean-Claude, Perier, Marie-Cecile, Mulak, Genevieve, Hermida, Jean-Sylvain, Milliez, Paul, Gras, Daniel, Cesari, Olivier, Hidden-Lucet, Françoise, Anselme, Frederic, Chevalier, Philippe, Maury, Philippe, Sadoul, Nicolas, Bordachar, Pierre, Cazeau, Serge, Chauvin, Michel, Empana, Jean-Philippe, Jouven, Xavier, Daubert, Jean-Claude, Le Heuzey, Jean-Yves, Le Heuzey, Jean-Yves, Cauchemez, Bruno, Khemache, Alain, Thomas, Olivier, Hermida, Jean-Sylvain, Kubala, Mathieu, Mathiron, Armelle, Traullé, Sarah, Dupuis, Jean-Marc, Foucault, Anthony, Tassin, Aude, Algalarrondo, Vincent, Dinanian, Sylvie, Juin, Christophe, Sebag, Claude, Briand, Florent, Guignier, Alexandre, Janin, Sébastien, Champ-Rigot, Laure, Gomes, Sophie, Milliez, Paul, Pellissier, Arnaud, Scanu, Patrice, Barthez, Olivier, Bertaux-Cattarossi, Géraldine, Duvernay-Debin, Régine, Farnier, Fabien, Laurent, Gabriel, Martel-Bourcier, Alexandra, Defaye, Pascal, Jacon, Peggy, Durand, Cyril, Durand-Dubief, Alexis, Monsarrat, Nicolas, Poty, Hervé, Boulé, Stéphane, Brigadeau, François, Fossati, Frédéric, Guédon-Moreau, Laurence, Jarwe, Mustapha, Kacet, Salem, Klug, Didier, Kouakam, Claude, Lacroix, Dominique, Marquie, Christelle, Blanc, Patrick, Echahidi, Najmeddine, Espaliat, Eric, Guy-Moyat, Benoit, Lesage, Jérôme, Deharo, Jean-Claude, Franceschi, Frédéric, Prévot, Sébastien, Aliot, Etienne, Andronache, Marius, Brembillat Perrot, Béatrice, de Chillou, Christian, Sadoul, Nicolas, Badenco, Nicolas, Chastre, Thomas, Duthoit, Guillaume, Frank, Robert, Gandjbakhch, Estelle, Gartenlaub, Olivier, Hidden-Lucet, Françoise, Himbert, Caroline, Waintraub, Xavier, Zerah, Thierry, Bauley, Karine, Chabert, Jean-Pierre, Deschildre, Alain, Lesaffre, François, Martin, Angéline, Rio, Colette, Daubert, Jean-Claude, Leclercq, Christophe, Mabo, Philippe, Pavin, Dominique, Anselme, Fréderic, Godin, Bénédicte, Savouré, Arnaud, Bisch, Laurence, Da Costa, Antoine, Romeyer, Cécile, Bakou Boula, Babe, Bronner, François, Chauvin, Michel, Douchet, Marie-Pierre, Jesel, Laurence, Marzak, Halim, Schatz, Alexandre, Cardin, Christelle, Chilon, Talia, Delay, Marc, Duparc, Alexandre, Garderes-Rollin, Anne, Maury, Philippe, Mondoly, Pierre, Somody, Elisabeth, Thomson, Emile, Chevalier, Philippe, Dulac, Arnaud, Mlotek, Marcin, Nonin-Babary, Emilie, Jouven, Xavier, Lavergne, Thomas, Le Heuzey, Jean-Yves, Marijon, Eloi, Otmani, Akli, Burban, Marc, Cebron, Jean-Pierre, Gras, Daniel, Barraud, Pascal, Langlade, Stéphane, Lipiecki, Janusz, Philippot, François, Richard, Alain, Robin, Isabelle, Schandrin, Christian, Vacher, Dominique, Cardin, Christelle, Reza Rezaei, Mohammed, Rumeau, Philippe, Fouché, Renaud, Fromentin, Stéphane, Khattar, Pierre, Le Potier, Jacques, Mouhid, Jamal, Palud, Laurent, Andres, Henri, Boureux, Christian, Chopat, Patrick, Nadji, Georges, Sultan, Pierre, Targosz, Frédéric, Doazan, Jean-Philippe, El Hajjaji, Nourédine, Hannachi, Sofiene, Noblemaire, Romain, Somody, Elisabeth, Copie, Xavier, Lascault, Gilles, Paziaud, Olivier, Piot, Olivier, Billon, Olivier, Gully, Claude, Haddad, Georges, Lipp, Damien, Mouhoub, Driss, Bru, Paul, Duplantier-Duchêne, Cécile, Milhem, Antoine, Bertrand, Julien, Boursier, Michel, Khalife, Khalifé, Zannad, Noura, Zanutto, Aude, Cuvelier, Estelle, Donfafk, Cécile, Graux, Pierre, Guiot, Aurélie, Guyomar, Yves, Heuls, Sébastien, Kallumannil, John, Semichon, Marc, Gal, Benjamin, Lopez, Michel, Pineau, Julien, Dreyfus, Xavier, Hammer, Laure, Petit, Luc, Harle, Xavier, Laborderie, Julien, Albenque, Jean-Paul, Boveda, Serge, Combes, Nicolas, Combes, Stéphane, Goutner, Christophe, Césari, Olivier, Chenevez, Patrick, Loose, Christophe, Peycher, Patrick, Durand, Cyril, Durand-Dubief, Alexis, Poty, Hervé, Alonso, Christine, Cazeau, Serge, Grimard, Caroline, Jauvert, Gael, and Lazarus, Arnaud

Published
2015
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29. Guidelines issued by the French Society of Cardiology concerning the competence, performance and environment required in the practice of diagnostic and interventional cardiac electrophysiology

Author

Piot, Olivier, Anselme, Frédéric, Bovéda, Serge, Chauvin, Michel, Daubert, Jean-Claude, Defaye, Pascal, Deharo, Jean-Claude, Gras, Daniel, Hermida, Jean-Sylvain, Kacet, Salem, Klug, Didier, Leenhardt, Antoine, le Heuzey, Jean-Yves, Mabo, Philippe, Pisapia, André, Sadoul, Nicolas, Salvador-Mazenq, Michèle, and Cazeau, Serge

Published
2011
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31. High-degree atrioventricular block complicating ST segment elevation myocardial infarction in the contemporary era

Author

Auffret, Vincent, Loirat, Aurélie, Leurent, Guillaume, Martins, Raphael P, Filippi, Emmanuelle, Coudert, Isabelle, Hacot, Jean Philippe, Gilard, Martine, Castellant, Philippe, Rialan, Antoine, Delaunay, Régis, Rouault, Gilles, Druelles, Philippe, Boulanger, Bertrand, Treuil, Josiane, Avez, Bertrand, Bedossa, Marc, Boulmier, Dominique, Le Guellec, Marielle, Daubert, Jean-Claude, and Le Breton, Hervé

Published
2016
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38. Redefining the Classifications of Response to Cardiac Resynchronization Therapy: Results From the REVERSE Study

Author

Gold, Michael R, Rickard, John, Daubert, Jean-Claude, Zimmerman, Patrick, Linde, Cecilia, Medical University of South Carolina [Charleston] (MUSC), Cleveland Clinic, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Medtronics, Karolinska University Hospital [Stockholm], Karolinska Institute, The REVERSE trial was supported by Medtronic, Inc., Minneapolis, Minnesota. Drs. Gold, Linde, and Daubert have served as consultants to and received research grants from Medtronic. Dr. Gold has served as a consultant and receives research grants from Boston Scientific. Dr. Rickard has received a research grant from Abbott, and has been a consultant for Medtronic. Dr. Daubert has received research grants, speaker honoraria, and consulting fees from Medtronic and St. Jude Medical. Dr. Zimmerman has been an employee of Medtronic. Dr. Linde has received honoraria payments from Medtronic, Abbott, and Impulse Dynamics, and has been supported by grants from the Swedish Heart Lung Foundation and Stockholm City Council., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, Ventricular Dysfunction, Left, Treatment Outcome, response, Ventricular Remodeling, Humans, cardiac resynchronization therapy, heart failure, [SDV.IB]Life Sciences [q-bio]/Bioengineering, mortality, remodeling
Abstract

International audience; OBJECTIVES: This study sought to assess the impact of a more detailed classification of response on survival. BACKGROUND: Cardiac resynchronization therapy (CRT) improves functional status and outcomes in selected populations with heart failure (HF). However, approximately 30% of patients do not improve with CRT by various metrics, and they are traditionally classified as nonresponders. METHODS: REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) was a randomized trial of CRT among patients with mild HF. Patients were classified as Improved, Stabilized, or Worsened using prespecified criteria based on the clinical composite score (CCS) and change in left ventricular end-systolic volume index (LVESVi). All-cause mortality across CRT ON subgroups at 5 years was compared. RESULTS: Of the 406 subjects surviving 1 year, 5-year survival differed between CCS subgroups (p = 0.03), with increased mortality in the Worsened response group. Of the 353 subjects with adequate echocardiograms, survival differed significantly between response groups (p

Published
2021

46. Incidence of sudden cardiac death after ventricular fibrillation complicating acute myocardial infarction: a 5-year cause-of-death analysis of the FAST-MI 2005 registry†

Author

Bougouin, Wulfran, Marijon, Eloi, Puymirat, Etienne, Defaye, Pascal, Celermajer, David S., Le Heuzey, Jean-Yves, Boveda, Serge, Kacet, Salem, Mabo, Philippe, Barnay, Claude, Da Costa, Antoine, Deharo, Jean-Claude, Daubert, Jean-Claude, Ferrières, Jean, Simon, Tabassome, and Danchin, Nicolas

Published
2014
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47. Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure -- the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) study

Author

Linde, Cecilia, Gold, Michael, Abraham, William T., and Daubert, Jean-Claude

Subjects
Heart failure -- Care and treatment, Cardiac patients -- Care and treatment, Medical colleges, Cardiovascular agents, Medical research, Medicine, Experimental, Clinical trials, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.03.002 Byline: Cecilia Linde (a), Michael Gold (b), William T. Abraham (c), Jean-Claude Daubert (d) Abstract: Cardiac resynchronization therapy (CRT) improves symptoms, reduces heart failure (HF)-related hospitalizations, and reverses left ventricular remodeling in some patients with moderate to severe HF and ventricular dyssynchrony defined by a prolonged QRS duration. The effects of CRT on HF outcomes in patients with asymptomatic left ventricular dysfunction (ALVD) or mild HF remain to be determined. Author Affiliation: (a) Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (b) Division of Cardiology, Medical University of South Carolina, Charleston, SC (c) Division of Cardiovascular Medicine and the Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio (d) Departement de Cardiologie, CHU, Rennes, France Article History: Received 18 November 2004; Accepted 1 March 2005 Article Note: (footnote) Supported by Medtronic Bakken Research Center BV, Maastricht, NL, Europe, and Medtronic Inc, Minneapolis, Minn.

Published
2006

48. The effect of cardiac resynchronization on morbidity and mortality in heart failure

Author

Cleland, John G. F., Daubert, Jean-Claude, Erdmann, Erland, Freemantle, Nick, Gras, Daniel, Kappenberger, Lukas, and Tavazzi, Luigi

Subjects
Morbidity -- Research, Mortality -- United States, Mortality -- Risk factors, Heart failure -- Risk factors
Abstract

Cardiac resynchronization improves symptoms and the quality of life and also reduces complications and the risk of death among patients with heart failure and cardiac dyssynchrony. The implantation of a cardiac-resynchronization device should routinely be considered in such patients.

Published
2005

49. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)

Author

Brignole, Michele, Auricchio, Angelo, Baron-Esquivias, Gonzalo, Bordachar, Pierre, Boriani, Giuseppe, Breithardt, Ole-A, Cleland, John, Deharo, Jean-Claude, Delgado, Victoria, Elliott, Perry M., Gorenek, Bulent, Israel, Carsten W., Leclercq, Christophe, Linde, Cecilia, Mont, Lluís, Padeletti, Luigi, Sutton, Richard, Vardas, Panos E., Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Cetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W., Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Kirchhof, Paulus, Blomstrom-Lundqvist, Carina, Badano, Luigi P., Aliyev, Farid, Bänsch, Dietmar, Baumgartner, Helmut, Bsata, Walid, Buser, Peter, Charron, Philippe, Daubert, Jean-Claude, Dobreanu, Dan, Faerestrand, Svein, Hasdai, David, Hoes, Arno W., Le Heuzey, Jean-Yves, Mavrakis, Hercules, McDonagh, Theresa, Merino, Jose Luis, Nawar, Mostapha M., Nielsen, Jens Cosedis, Pieske, Burkert, Poposka, Lidija, Ruschitzka, Frank, Tendera, Michal, Van Gelder, Isabelle C., and Wilson, Carol M.

Published
2013
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