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3. The role of actigraphy in sleep medicine

Author

Acker, Jens G., Becker-Carus, C., Büttner-Teleaga, Antje, Cassel, Werner, Danker-Hopfe, Heidi, Dück, Alexander, Frohn, Corinna, Hein, Holger, Penzel, Thomas, Rodenbeck, Andrea, Roenneberg, Till, Sauter, Cornelia, Weeß, Hans-Günter, Zeitlhofer, Josef, and Richter, Kneginja

Published
2021
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9. Nocturnal Brain Activity Differs with Age and Sex: Comparisons of Sleep EEG Power Spectra Between Young and Elderly Men, and Between 60–80-Year-Old Men and Women

Author

Eggert, Torsten, Dorn, Hans, and Danker-Hopfe, Heidi

Subjects
topography, TFCE, aging, gender, qEEG, neurophysiology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research
Abstract

Purpose: Quantification of nocturnal EEG activity has emerged as a promising extension to the conventional sleep evaluation approach. To date, studies focusing on quantitative sleep EEG data in relation to age and sex have revealed considerable variation across lifespan and differences between men and women. However, sleep EEG power values from elderly individuals are still rare. The present secondary analysis aimed to fill this gap. Participants and Methods: Sleep EEG data of 30 healthy elderly males (mean age +/- SD: 69.1 +/- 5.5 years), 30 healthy elderly females (67.8 +/- 5.7 years), and of 30 healthy young males (25.6 +/- 2.4 years) have been collected in three different studies with the same experimental design. Each individual contributed three polysomnographic recordings without any intervention to the analysis. Sleep recordings were performed and evaluated according to the standard of the American Academy of Sleep Medicine. Sleep EEG signals were derived from 19 electrode sites. Sleep-stage specific global and regional EEG power were compared between samples using a permutation-based statistic in combination with the threshold-free cluster enhancement method. Results: The present results showed pronounced differences in sleep EEG power between older men and women. The nocturnal EEG activity of older women was generally larger than that of older men, confirming previously reported variations with sex in younger individuals. Aging was reflected by differences in EEG power between young and elderly men for lower frequencies and for the sleep spindle frequency range, again consistent with prior studies. Conclusion: The findings of this investigation complement those of earlier studies. They add to the understanding of nocturnal brain activity manifestation in senior adulthood and show how it differs with age in males. Unfortunately, the lack of information on young women prevents a similar insight for females.

Published
2021

21. REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder

Author

Repantis, Dimitris, Wermuth, Katharina, Tsamitros, Nikolaos, Danker-Hopfe, Heidi, Bublitz, Jan Christoph, Kühn, Simone, and Dresler, Martin

Subjects
REM sleep suppression, trastorno de estrés postraumático, Acute stress disorder, 睡眠剥夺, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], RC435-571, supresión del sueño REM, Article, sueño REM, polisomnografía, REM睡眠, All institutes and research themes of the Radboud University Medical Center, polysomnography, 130 000 Cognitive Neurology & Memory, 多导睡眠检测, Psychiatry, trastorno de estrés agudo, 二级预防, 急性应激障碍, REM睡眠抑制, prevención secundaria, sleep deprivation, la privación del sueño, posttraumatic stress disorder, 创伤后应激障碍, REM sleep, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, secondary prevention
Abstract

Increasing evidence supports a close link between REM sleep and the consolidation of emotionally toned memories such as traumatic experiences. In order to investigate the role of sleep for the development of symptoms related to traumatic experiences, beyond experimental models in the laboratory, sleep of acutely traumatised individuals may be examined on the first night after trauma. This might allow us to identify EEG variables predicting the development of posttraumatic stress disorder (PTSD) symptoms, and guide the way to novel sleep interventions to prevent PTSD. Based on our experience, patients' acceptance of polysomnography in the first hours after treatment in an emergency room poses obstacles to such a strategy. Wearable, self-applicable sleep recorders might be an option for the investigation of sleep in the aftermath of trauma. They would considerably decrease the perceived burden for patients and thus increase the likelihood of successful patient recruitment. As one potential sleep intervention, sleep deprivation directly after trauma has been suggested to reduce the consolidation of traumatic memories and hence act as a secondary preventive measure. However, experimental data from sleep deprivation studies in healthy volunteers with the trauma film paradigm have been inconclusive regarding the beneficial or detrimental effects of sleep on traumatic memory processing. Depending on further insights into the role of sleep in traumatic memory consolidation through observational and experimental studies, several options for therapeutic sleep interventions are conceivable: besides behavioural sleep deprivation, selective REM sleep suppression or enhancement by a pharmacological intervention into the serotonergic, noradrenergic or cholinergic systems might provide novel therapeutic options. While REM-modulating drugs have been used with some success for the prevention of PTSD after trauma, they have never been tried before the first night of sleep. In conclusion, more experimental and observational research is needed before sleep interventions are performed in actual trauma victims.La evidencia creciente respalda un vínculo cercano entre el sueño REM y la consolidación de recuerdos emocionalmente teñidos tales como las experiencias traumáticas. Con el fin de investigar el papel del sueño REM para el desarrollo de síntomas clínicos relacionados con experiencias traumáticas, más allá de los modelos experimentales en el laboratorio, se examinó el sueño de individuos traumatizados de forma aguda la primera noche después del evento traumático. Esto nos permitiría identificar las variables de EEG que predicen el desarrollo de los síntomas del trastorno de estrés postraumático (TEPT) y guiar el camino hacia nuevas intervenciones del sueño para prevenir el TEPT. Basado en nuestra experiencia, la aceptación de los pacientes de la polisomnografía completa en las primeras horas después de su tratamiento en una sala de emergencias plantea obstáculos para dicha estrategia. Sistemas de registro de sueño que sean portables y autoinstalables podrían ser una opción para la investigación del sueño en las secuelas del trauma. Disminuirían considerablemente la carga percibida para los pacientes y, por lo tanto, aumentarían la probabilidad de un reclutamiento exitoso de pacientes. Como una posible intervención del sueño, se ha sugerido que la privación total del sueño posterior al trauma reduce la consolidación de los recuerdos traumáticos y, por lo tanto, actúa como una medida preventiva secundaria.Sin embargo, los datos experimentales de estudios de privación del sueño en voluntarios sanos con el ‘trauma film paradigm’ no han sido concluyentes con respecto a los efectos beneficiosos o perjudiciales del sueño en el procesamiento de la memoria traumática.Dado que la privación del sueño en la primera noche después de la traumatización podría no ser aceptable para muchas personas traumatizadas, la supresión selectiva del sueño REM, por ejemplo, mediante una intervención farmacológica, podría ser una alternativa dado el papel del sueño REM en la consolidación de la memoria emocional. Si bien los antidepresivos supresores de REM ya se han utilizado con cierto éxito para la prevención del TEPT, hasta ahora no se han probado antes de la primera noche de sueño después de un trauma. En conclusión, se necesita más investigación experimental y observacional antes de que se realicen intervenciones de sueño en víctimas de trauma reales.越来越多的证据支持REM睡眠与创伤经历之类的情绪化记忆巩固之间的紧密联系。为了探究REM睡眠在创伤经历相关临床症状发展中的作用, 除实验室中的实验模型之外, 还可以考查急性创伤者在创伤事件发生后第一晚的睡眠。这可能帮助我们识别出预测创伤后应激障碍 (PTSD) 症状发展的EEG变量, 并为预防PTSD的新型睡眠干预提供指导。根据我们的经验, 患者在急诊室治疗前几个小时接受的全面多导睡眠监测, 对此策略有所妨碍。可自用穿戴式睡眠记录仪可能是创伤后睡眠研究的一种选择。它们将大大减轻患者负担, 从而增加成功招募患者的可能性。作为一种潜在睡眠干预措施的完全睡眠剥夺, 已被建议在创伤后立即进行, 以减少创伤记忆的巩固, 从而作为二级预防措施。然而, 就睡眠对创伤记忆加工的影响是利是弊, 在对健康志愿者采用创伤电影范式进行的睡眠剥夺研究的实验数据中尚无定论。鉴于创伤后第一晚的睡眠剥夺可能无法被许多创伤者所接受, 并考虑到REM睡眠在情绪记忆巩固中的作用, 选择性REM睡眠抑制 (例如药物干预) 可能是一种替代方法。尽管抑制REM的抗抑郁药已经成功用于创伤后PTSD的预防, 但从未尝试在第一晚睡眠中应用。总之, 在对真实的创伤受害者进行睡眠干预之前, 需要更多的实验和观察性研究。.

Published
2020

27. Free Communication Abstracts

Author

Kaul, Prashan T., Passafiume, Jasonm, O’Hara, Bruce F., Vetrivelan, Ramalingam, Mallick, Hruda Nanda, Kumar, Velayadhan Mohan, Zhan, G.-X., Serrano, F., Fenik, P., Hsu, R., Kong, L., Pratico, D., Klann, E., Veasey, S. C., Mahapatra, Ambika Prasad K., Kumar, Velayudhan Mohan, Kuwaki, Tomoyuki, Den, Ben-Shiang, Nakamura, Akira, Zhang, Wei, Yanagisawa, Masashi, Fukuda, Yasuichiro, Andersen, Monica L., Tufik, Sergio, Antunes, Isabela B., Perry, Juliana C., Tufik, S., Andersen, M. L., Batista, M. C., Calzavara, M. B., Costa, J. L., Frussa-Filho, Désarnaud, F., Murillo-Rodriguez, E., Gerashchenko, D., Shiromani, S., Lin, L., Nishino, S., Mignot, E., Shiromani, P. J., Blanco-Centurion, Carlos, Shiromani, Priyattam J., Ling, L., Xu, M., Blanco-Centurion, C., Mikko, Härmä, Mikael, Sallinen, Jain, Shamini, Mills, Paul J., Liu, Lianqi, Ancoli-Israel, Sonia, Haimov, I., Breznitz, N., Shiloh, S., Silvestri, R., Aricò, I., Mento, G., Gagliano, A., Calarese, T., di Perri, C., Epstein, R., Tzischinsky, O., Naveh, R., Herer, P., Pillar, G., Adami, H., Lavie, P., Marks, Gerald A., Sachs, Oren, Birabil, Christian C., Roky, Rachida, Benaji, Brahim, Benchekroun, Majda Taoudi, Chapotot, Florian, Buguet, Alain, Rao, Uma, Poland, Russell E., Puvanendran, K., Mishima, Yumiko, Mishima, Kazuo, Hozumi, Satoshi, Shimizu, Tetsuo, Hishikawa, Yasuo, Toledo, Juan C., Koyama, Yoshimasa, Kayama, Yukihiko, Iwasaki, Hiroshi, Kawauchi, Akihiro, Miki, Tsuneharo, Yaegashi, Hironobu, Takahashi, Yasuro, Inoue, Yuichi, Ishiura, Daiki, Yamamoto, Keisuke, Nakao, Mitsuyuki, Katayama, Norihito, Yamamoto, Mitsuaki, Matsumoto, Yasuhiro, Satoh, Kohtoku, Tozawa, Takuma, Lack, Leon, Bramwell, Toby, Wright, Helen, Gradisar, Michael, Storrs, P., Mckenna, F., Hume, K., Loshkarev, Alexander A., Rodionova, Elena I., Levichkina, Ekaterina V., Pigarev, Ivan N., de Koninck, Joseph, Maganti, Rama, Biswas, Amit, Kiyashchenko, Lyudmila I., Mileykovskiy, Boris Y., Siegel, Jerome M., Methippara, Melvi, Kumar, Sunil, Alam, Noor, Szymusiak, Ronald, Mcginty, Dennis, Richardson, Heidi L., Parslow, Peter M., Walker, Adrian M., Harding, Richard, Horne, Rosemary S. C., Tzchishinsky, O., Shochat, T., Nictren, A., Portnoy, T., Peled, R., Bootzin, Richard, Aparicio, S., Garau, C., Rial, R. V., Nicolau, M. C., Rivero, M., Esteban, S., Barriga, M. C., Kuenzel, H. E., Steiger, A., Held, K., Antonijevic, I. A., Frieboes, R. M., Murck, H., Mairesse, Olivier, de Valck, Elke, Theuns, Peter, Cluydts, Raymond, Gvilia, I., Turner, A., Mcginty, D., Szymusiak, R., Lyamin, O. I., Mukhametov, L. M., Kosenko, P. O., Vyssotski, A. L., Lapierre, J. L., Pokidchenko, T. M., Lipp, H. P., Hsieh, Kc, Nguyen, D., Lai, Y. Y., Ramanathan, Lalini, Bashir, Muhammad-Tariq, Guzman-Marin, Ruben, Xu, Feng, Chew, Keng-Tee, Cassaglia, P., Griffiths, R., Walker, A. M., Grant, D. A., Wild, G. Zoccoli, Matsuura, Noriko, Adachi, Naomi, Kaji, Megumi, Aritomi, Ryoji, Basishvili, T., Gogichadze, M., Rukhadze, I., Emukhvari, N., Fujita, Etsunori, Ogura, Yumi, Ochiai, Naoki, Murata, Kohji, Kamei, Tsutomu, Ueno, Yoshiyuki, Kaneko, Shigehiko, Voss, U., Tuin, I., Kessler, K. R., Morales, B., Ziemann, U., Steinmetz, H., Auburger, G., Mishra, J. P. N., Pedemonte, Marisa, Bentancor, Claudia, Velluti, Ricardo A., Zoccoli, Giovanna, Grant, Daniel A., Wild, Jennene, de Gennaro, Luigi, Curcio, Giuseppe, Fratello, Fabiana, Marzano, Cristina, Moroni, Fabio, Pellicciari, Maria Concetta, Ferrara, Michele, Sforza, Emilia, Pal, Dinesh, Mallick, Birendra Nath, Hornung, Orla P., Regen, Francesca, Danker-Hopfe, Heidi, Dorn, Hans, Schredl, Michael, Heuser, Isabella, Rai, Seema, Alam, Md Noor, Aschbacher, Kirstin, Dimsdale, Joel E., Calleran, Susan, Ziegler, Michael G., Patterson, Thomas L., Grant, Igor, Kang, J.-S., Youngstedt, S. D., Kline, C. E., Zielinski, M., Lee, A., Devlin, T. M., Kripke, D. F., Regen, F., Dorn, H., Danker-Hopfe, H., Bassi, Alejandro, Vivaldi, Ennio A., Ocampo-Garcés, Adrian, Galland, Barbara, Tan, Evan, Taylor, Barry, Goulden, Marie, Peled, Nir, Shitrit, David, Kramer, Mordechai R., Dunleavy, Mark, Lane, Donncha, O’Halloran, Ken, Bradford, Aidan, Sverteczki, Melinda, Sándor, Lázár Alpár, Linda, Havrán, TamÁs, Kis, Péter, Rigó, Szilvia, Csóka, Robert, Bódizs, Mccarley, Robert W., Basheer, Radhika, Strecker, Robert E., Farooqui, Ausaf A., Gulia, Kamalesh K., Balakrishnan, D., Thirunavukkarasu, S., Edwin, R., Virudhagirinathan, B. S., Kumar, Deependra, and Srividya, Rajagopalan

Published
2005
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30. Restless Legs Syndrome Prevalence and Clinical Correlates Among Psychiatric Inpatients: A Multicenter Study.

Author

Weber, Franziska C., Danker-Hopfe, Heidi, Dogan-Sander, Ezgi, Frase, Lukas, Hansel, Anna, Mauche, Nicole, Mikutta, Christian, Nemeth, Diana, Richter, Kneginja, Schilling, Claudia, Sebestova, Martina, Spath, Marian M., Nissen, Christoph, and Wetter, Thomas C.

Subjects
RESTLESS legs syndrome, SLEEP quality, EPWORTH Sleepiness Scale, LOGISTIC regression analysis, BODY mass index, ALCOHOL drinking
Abstract

Background: There are only limited reports on the prevalence of restless legs syndrome (RLS) in patients with psychiatric disorders. The present study aimed to evaluate the prevalence and clinical correlates in psychiatric inpatients in Germany and Switzerland. Methods: This is a multicenter cross-sectional study of psychiatric inpatients with an age above 18 years that were diagnosed and evaluated face-to-face using the International RLS Study Group criteria (IRLSSG) and the International RLS severity scale (IRLS). In addition to sociodemographic and biometric data, sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Patient Health Questionnaire (PHQ-9). In addition to univariate statistics used to describe and statistically analyze differences in variables of interest between patients with and without RLS, a logistic model was employed to identify predictors for the occurrence of RLS. Results: The prevalence of RLS in a sample of 317 psychiatric inpatients was 16.4%, and 76.9% of these were diagnosed with RLS for the first time. RLS severity was moderate to severe (IRLS ± SD: 20.3 ± 8.4). The prevalences in women (p = 0.0036) and in first-degree relatives with RLS (p = 0.0108) as well as the body mass index (BMI, p = 0.0161) were significantly higher among patients with RLS, while alcohol consumption was significantly lower in the RLS group. With the exception of atypical antipsychotics, treatment with psychotropic drugs was not associated with RLS symptoms. Regarding subjective sleep quality and mood, scores of the PSQI (p = 0.0007), ISI (p = 0.0003), and ESS (p = 0.0005) were higher in patients with RLS, while PHQ-9 scores were not different. A logistic regression analysis identified gender (OR 2.67; 95% CI [1.25; 5.72]), first-degree relatives with RLS (OR 3.29; 95% CI [1.11; 9.73], ESS score (OR 1.09; 95% CI [1.01; 1.17]), and rare alcohol consumption (OR 0.45; 95% CI [0.22; 0.94] as predictors for RLS. Conclusions: Clinically significant RLS had a high prevalence in psychiatric patients. RLS was associated with higher BMI, impaired sleep quality, and lower alcohol consumption. A systematic assessment of restless legs symptoms might contribute to improve the treatment of psychiatric patients. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Effects of 2.45 GHz Wi‐Fi exposure on sleep‐dependent memory consolidation.

Author

Bueno‐Lopez, Ana, Eggert, Torsten, Dorn, Hans, Schmid, Gernot, Hirtl, Rene, and Danker‐Hopfe, Heidi

Subjects
WIRELESS Internet, EXPLICIT memory, CELL phone systems, SLEEP spindles, MEMORY, FACE perception
Abstract

Studies have reported that exposure to radiofrequency electromagnetic fields (RF‐EMF) emitted by mobile telephony might affect specific sleep features. Possible effects of RF‐EMF emitted by Wi‐Fi networks on sleep‐dependent memory consolidation processes have not been investigated so far. The present study explored the impact of an all‐night Wi‐Fi (2.45 GHz) exposure on sleep‐dependent memory consolidation and its associated physiological correlates. Thirty young males (mean ± standard deviation [SD]: 24.1 ± 2.9 years) participated in this double‐blind, randomized, sham‐controlled crossover study. Participants spent five nights in the laboratory. The first night was an adaptation/screening night. The second and fourth nights were baseline nights, each followed consecutively by an experimental night with either Wi‐Fi (maximum: psSAR10g = <25 mW/kg; 6 min average: <6.4 mW/kg) or sham exposure. Declarative, emotional and procedural memory performances were measured using a word pair, a sequential finger tapping and a face recognition task, respectively. Furthermore, learning‐associated brain activity parameters (power spectra for slow oscillations and in the spindle frequency range) were analysed. Although emotional and procedural memory were not affected by RF‐EMF exposure, overnight improvement in the declarative task was significantly better in the Wi‐Fi condition. However, none of the post‐learning sleep‐specific parameters was affected by exposure. Thus, the significant effect of Wi‐Fi exposure on declarative memory observed at the behavioural level was not supported by results at the physiological level. Due to these inconsistencies, this result could also be a random finding. [ABSTRACT FROM AUTHOR]

Published
2021
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