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5 results on '"Daniel Espinouse"'

1. Groshong or implanted catheter infections in ambulatory haematological patients

Author

Raphaelle Girard, Catherine Traullé, Nathalie DeSantis, Daniel Espinouse, Sophie Gardes, and Bertrand Coiffier

Subjects
Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Summary: Incidence rates of bacteraemia and catheter-related infections were measured prospectively amongst haematological patients having long-term catheters and hospitalised in the ambulatory care unit between November 2005 and October 2006. The following risk factors were collected: age, sex, catheter type, follow-up duration, level of personal hygiene, pathology, number of lines of treatment, autograft and erythropoietin treatment.340 patients were included, having 353 catheters (100 of the Groshong-type, followed during 17,621 days, and 253 of the type with implantable ports, followed during 51,049 days). 0.13 catheter-related infections and 0.07 bacteraemia per 100 catheter days were observed with the Groshong-type catheter, whereas 0.05 (P

Published
2010
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2. Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma

Author

Fadhela Bouafia, A Eljaafari-Corbin, Pascal Roy, Charles Dumontet, H Saad, Gilles Salles, Catherine Thieblemont, B. Coiffier, Daniel Espinouse, C Du Manoir-Baumgarten, Olivier Hequet, N Roch, P Arnaud, Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, Male, Melphalan, medicine.medical_specialty, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Transplantation Conditioning, medicine.medical_treatment, Transplantation, Autologous, Gastroenterology, 03 medical and health sciences, Amifostine, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Mucositis, Humans, Medicine, Multiple myeloma, Aged, Peripheral Blood Stem Cell Transplantation, Stomatitis, Transplantation, Chemotherapy, business.industry, Graft Survival, Mouth Mucosa, Hematology, Middle Aged, medicine.disease, 3. Good health, Kinetics, Treatment Outcome, 030220 oncology & carcinogenesis, Anesthesia, Toxicity, Vomiting, Female, medicine.symptom, Multiple Myeloma, business, 030215 immunology, medicine.drug
Abstract

High-dose melphalan (HDM) has been adopted as standard therapy in the treatment of multiple myeloma. This treatment is associated with non-selective cytotoxicity, causing oral mucositis as the major non-hematological side-effect. Amifostine is a cytoprotector which prevents toxicity induced by anticancer therapy. We prospectively compared two groups of patients who either received (group A, n = 21) or did not receive (group B, n = 20) amifostine (740 mg/m(2)) before HDM (200 mg/m(2)) followed by autologous peripheral blood progenitor cell transplantation. The occurrence of severe oral mucositis was significantly decreased in group A in comparison to group B (33% vs 65%, P < 0.05). Six patients in group A required opioid analgesic therapy during a mean period of 4.8 days as compared to eight patients for 6.5 days in group B (P = NS). Delayed vomiting was less frequent in group A (43% vs 70%, P = 0.07) and significantly less severe in group A (grade 2-4) vomiting: two patients vs nine patients, P < 0.02). No difference was observed between the two groups in either hematological toxicity after HDM or in response rate. Grade I emesis was the only immediate side-effect observed after amifostine administration. We conclude that amifostine can reduce mucositis induced by HDM.

Published
2002

3. Gram-positive infections in neutropenic patients: glycopeptide antibiotic choice

Author

Monique Chomarat, Jean-Pierre Flandrois, Daniel Espinouse, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hématologie clinique, CHU Lyon, Bioinformatique, phylogénie et génomique évolutive (BPGE), Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Pharmacology, Microbiology (medical), 0303 health sciences, 030306 microbiology, business.industry, medicine.drug_class, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Glycopeptide antibiotic, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Medicine, Pharmacology (medical), 030212 general & internal medicine, business, ComputingMilieux_MISCELLANEOUS, Gram
Abstract

International audience

Published
1992

5. Groshong or implanted catheter infections in ambulatory haematological patients

Author

Nathalie DeSantis, Raphaelle Girard, Sophie Gardes, Catherine Traulle, Bertrand Coiffier, and Daniel Espinouse

Subjects
Male, Catheterization, Central Venous, medicine.medical_specialty, Multivariate analysis, Bacteremia, lcsh:Infectious and parasitic diseases, Catheters, Indwelling, Personal hygiene, Ambulatory care, Internal medicine, Humans, Medicine, lcsh:RC109-216, Prospective Studies, Prospective cohort study, Hematology, Surveillance, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, General Medicine, Surgery, Catheter, Infectious Diseases, Erythropoietin, Catheter-Related Infections, Hematologic Neoplasms, Ambulatory, Bacteraemia, Female, Catheter-related infection, business, Haematology, medicine.drug
Abstract

Summary: Incidence rates of bacteraemia and catheter-related infections were measured prospectively amongst haematological patients having long-term catheters and hospitalised in the ambulatory care unit between November 2005 and October 2006. The following risk factors were collected: age, sex, catheter type, follow-up duration, level of personal hygiene, pathology, number of lines of treatment, autograft and erythropoietin treatment.340 patients were included, having 353 catheters (100 of the Groshong-type, followed during 17,621 days, and 253 of the type with implantable ports, followed during 51,049 days). 0.13 catheter-related infections and 0.07 bacteraemia per 100 catheter days were observed with the Groshong-type catheter, whereas 0.05 (P

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