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2. Retrospective Mapping of SAR Data for TTR Protein in Chemico-Biological Space Using Ligand Efficiency Indices as a Guide to Drug Discovery Strategies

Author

Nuria B. Centeno, Cele Abad-Zapatero, Marta Pinto, Gregori Valencia, Joan Nieto, Antoni Planas, Daniel Blasi, Gemma Arsequell, and Jordi Quintana

Subjects
Amyloid, Ligand efficiency, biology, Chemico-biological space, Stereochemistry, Chemistry, Drug discovery, Organic Chemistry, nutritional and metabolic diseases, Computational biology, TTR, Chemical space, Computer Science Applications, Polar surface area, Transthyretin, Binding efficiency, Structural Biology, Drug Discovery, Ligand efficiency indices, biology.protein, Amyloid polyneuropathy, Molecular Medicine
Abstract

We have previously reported the design and synthesis of ligands that stabilize Transthyretin protein (TTR) in order to obtain therapeutically active compounds for Familial Amyloid Polyneuropathy (FAP). We are hereby reporting a drug design strategy to optimize these ligands and map them in Chemico-Biological Space (CBS) using Ligand Efficiency Indices (LEIs). We use a binding efficiency index (BEI) based on the measured binding affinity related to the molecular weight (MW) of the compound combined with surface-binding efficiency index (SEI) based on Polar Surface Area (PSA). We will illustrate the use of these indices, combining three crucial variables (potency, MW and PSA) in a 2D graphical representation of chemical space, to perform a retrospective mapping of SAR data for a current TTR inhibitors database, and we propose prospective strategies to use these efficiency indices and chemico-biological space maps for optimization and drug design efforts for TTR ligands., This work was supported by a grant from the Fundaci Marat de TV3, Barcelona, Spain (Project Number: 080530/ 31/32).

Published
2011

3. Interpolating sequences on analytic Besov type spaces

Author

Jordi Pau, Daniel Blasi, Nicola Arcozzi, N. Arcozzi, D. Blasi, and J. Pau

Subjects
Multiplier (Fourier analysis), Discrete mathematics, INTERPOLATING SEQUENCES, Mathematics::Functional Analysis, General Mathematics, Mathematical analysis, Mathematics::Classical Analysis and ODEs, Mathematics::Analysis of PDEs, MAT/05 Analisi matematica, ANALYTIC BESOV SPACES, Type (model theory), Mathematics::Spectral Theory, Mathematics
Abstract

We characterize the interpolating sequences for the weighted analytic Besov spaces Bp(s), defined by the norm ∥f∥ p Bp(S) = |f(0) | P +∫ D |(1-|z| 2 )f(z)| p (1-|z| 2 ) s dA(z)/(1-|z| 2 ) 2’ , 1 < p < ∞ and 0 < s < 1, and for the corresponding multiplier spaces M(Bp(s)).

Published
2009

4. Common Dysregulated Genes in Endometriosis and Malignancies

Author

Daniel Blasioli Dentillo, Juliana Meola, Rui Alberto Ferriani, and Julio César Rosa-e-Silva

Subjects
cancer, endometriosis, gene expression, Gynecology and obstetrics, RG1-991
Abstract

Abstract Several authors have investigated the malignant transformation of endometriosis, which supports the hypothesis of the pre-neoplastic state of endometriotic lesions, but there are few data about the pathways and molecular events related to this phenomenon. This review provides current data about deregulated genes that may function as key factors in the malignant transition of endometriotic lesions. In order to do so, we first searched for studies that have screened differential gene expression between endometriotic tissues and normal endometrial tissue of women without endometriosis, and found only two articles with 139 deregulated genes. Further, using the PubMed database, we crossed the symbol of each gene with the terms related to malignancies, such as cancer and tumor, and obtained 9,619 articles, among which 444 were studies about gene expression associated with specific types of tumor. This revealed that more than 68% of the analyzed genes are also deregulated in cancer. We have also found genes functioning as tumor suppressors and an oncogene. In this study, we present a list of 95 informative genes in order to understand the genetic components that may be responsible for endometriosis' malignant transformation. However, future studies should be conducted to confirm these findings.

Published
2016
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5. Interpolation by positive harmonic functions.

Author

Daniel Blasi and Artur Nicolau

Subjects
*INTERPOLATION, *HARMONIC functions, *MATHEMATICAL sequences, *SPHERICAL harmonics, *CONES
Abstract

A natural interpolation problem in the cone of positive harmonic functions is considered and the corresponding interpolating sequences are geometrically described. [ABSTRACT FROM AUTHOR]

Published
2007
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6. Two Cases of Left Vertebral Artery Emerging from a Trunk in Common with the Left Subclavian Artery from the Aortic Arch.

Author

Ernesto Ottone, Nicolás, Casola, Leandro, Cirigliano, Vanina, Daniel Blasi, Esteban, Daniel Medan, Carlos, and Daniel Algieri, Rubén

Subjects
*VERTEBRAL artery, *SUBCLAVIAN artery, *THORACIC aorta, *EMBRYOLOGY, *BRACHIOCEPHALIC trunk
Abstract

Anomalies arising in the embryological development of the aortic arch and its branches are essencial in the emergence of variations in the origin and course of supra aortic vessels. Classically, 95% of cases, the aortic arch gives rise to the brachiocephalic artery, left common carotid artery and left subclavian artery. While the left vertebral artery arises normally from the left subclavian artery. In this presentation we describe two cases of the left vertebral artery being born of the aortic arch. The importance of anatomical knowledge of this arterial variety is fundamental for base neck and aortic arch surgery, in cervicothoracic trauma that compromises the vascular elements and in endovascular procedures in the region. [ABSTRACT FROM AUTHOR]

Published
2013
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