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2. Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2

Author

Richard N. Bohnsack, Sandeep K. Misra, Jianfang Liu, Mayumi Ishihara-Aoki, Michaela Pereckas, Kazuhiro Aoki, Gang Ren, Joshua S. Sharp, and Nancy M. Dahms

Subjects
Medicine, Science
Abstract

Abstract The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. CI-MPR is multifunctional and modulates embryonic growth and fetal size by downregulating circulating levels of the peptide hormone insulin-like growth factor 2 (IGF2). The extracellular region of CI-MPR comprises 15 homologous domains with binding sites for M6P-containing ligands located in domains 3, 5, 9, and 15, whereas IGF2 interacts with residues in domain 11. How a particular ligand affects the receptor’s conformation or its ability to bind other ligands remains poorly understood. To address these questions, we purified a soluble form of the receptor from newborn calf serum, carried out glycoproteomics to define the N-glycans at its 19 potential glycosylation sites, probed its ability to bind lysosomal enzymes in the presence and absence of IGF2 using surface plasmon resonance, and assessed its conformation in the presence and absence of IGF2 by negative-staining electron microscopy and hydroxyl radical protein footprinting studies. Together, our findings support the hypothesis that IGF2 acts as an allosteric inhibitor of lysosomal enzyme binding by inducing global conformational changes of CI-MPR.

Published
2024
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3. Multi-modal Land Cover Classification of Historical Aerial Images and Topographic Maps: A Comparative Study

Author

M. Dorozynski, F. Rottensteiner, F. Thiemann, M. Sester, T. Dahms, and M. Hovenbitzer

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Knowledge about land cover is relevant for many different applications such as updating topographic information systems, monitoring the environment, and planning future land cover. Particularly for monitoring, it is of interest to be not only aware of current land cover but of past land cover at different epochs, too. To allow for efficient, computer-aided spatio-temporal analysis, digital land cover information is required explicitly. In this context, historic aerial orthophotos and scanned historic topographic maps can serve as sources of information, in which land cover information is contained implicitly. The present work aims to automatically extract land cover from this data using classification. Thus, a deep learning-based multi-modal classifier is proposed to exploit information from aerial imagery and maps simultaneously for land cover prediction. Two variants of the classifier are trained, utilizing a supervised training strategy, for building segmentation and vegetation segmentation, respectively. Both classifiers are evaluated on independent test sets and compared to their respective two uni-modal counterparts, i.e. an aerial image classifier and a map classifier. Thus, a mean F1-score of 62.2% for multi-modal building segmentation and a mean F1-score of 83.7% for multimodal vegetation segmentation can be achieved. Detailed analysis of quantitative and qualitative results gives hints for promising directions for future research of multi-modal classifiers to further improve the performance of the multi-modal classifier.

Published
2024
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8. Measurement of Dielectric Properties of Thin Materials for Radomes Using Waveguide Cavities

Author

Tayla Dahms, Douglas B. Hayman, Bahare Mohamadzade, and Stephanie L. Smith

Subjects
radomes, dielectrics, thin materials, permittivity, loss tangent, waveguides, Computer engineering. Computer hardware, TK7885-7895, Electronic computers. Computer science, QA75.5-76.95
Abstract

We present waveguide cavity measurements used to evaluate several thin materials for use in radomes. In addition to the data on the materials, we show how these measurements can be performed with common laboratory equipment and simple calculations. We sought an approach that allowed candidate materials to be readily evaluated to deal with formerly selected materials becoming unavailable or cost-prohibitive. We used lengths of standard waveguide (WR650 and WR137 here) with readily manufactured irises and a vector network analyzer (Keysight N5225B here). To select the iris size and determine the limits of the simplifications in the equations used, we employed a full-wave 3D electromagnetic simulator (CST Microwave Studio). The equations required to calculate the dielectric properties of samples and their contribution to the equivalent system noise temperature from unloaded and loaded resonant frequencies and Q factors are shown. While these formulations can be found elsewhere, we did not find these assembled as conveniently in other studies in the literature. We also show that orienting the sample down the length of the cavity allows for higher-order modes to be fully utilized. We did not find this straightforward adaptation of the common cross-guide orientation in other works. Overall, the results allowed us to recommend three fabrics for use at the frequencies tested (1.7 and 5.6 GHz). The complete process is outlined to assist others in performing these measurements themselves.

Published
2024
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9. Impact of radiomics features, pulmonary emphysema score and muscle mass on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies

Author

Jakob Leonhardi, Ulrike Dahms, Benedikt Schnarkowski, Manuel Florian Struck, Anne-Kathrin Höhn, Sebastian Krämer, Sebastian Ebel, Gordian Prasse, Armin Frille, Timm Denecke, and Hans-Jonas Meyer

Subjects
Computed tomography, Biopsy, Lung cancer, Pneumothorax, Quantitative imaging, Diseases of the respiratory system, RC705-779
Abstract

Abstract Iatrogenic pneumothorax is a relevant complication of computed tomography (CT)-guided percutaneous lung biopsy. The aim of the present study was to analyze the prognostic significance of texture analysis, emphysema score and muscle mass derived from CT-imaging to predict postinterventional pneumothorax after CT-guided lung biopsy. Consecutive patients undergoing CT-guided percutaneous lung biopsy between 2012 and 2021 were analyzed. Multivariate logistic regression analysis included clinical risk factors and CT-imaging features to detect associations with pneumothorax development. Overall, 479 patients (178 females, mean age 65 ± 11.7 years) underwent CT-guided percutaneous lung biopsy of which 180 patients (37.5%) developed pneumothorax including 55 patients (11.5%) requiring chest tube placement. Risk factors associated with pneumothorax were chronic-obstructive pulmonary disease (COPD) (p = 0.03), age (p = 0.02), total lung capacity (p

Published
2024
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10. Psychological impact of autologous hematopoietic stem cell transplantation in systemic sclerosis patients and influence of resilience

Author

Marc Schmalzing, Michael Gernert, Matthias Fröhlich, Jörg Henes, Nathalie Schwindl, Leona Zerhusen, Lukas Berthold, Johannes Hewig, Andrea Kübler, Ann-Christin Pecher, Sonja Kleih-Dahms, Patrick-Pascal Strunz, and Philipp Ziebell

Subjects
systemic sclerosis, psychological impact, autologous hematopoietic stem cell transplantation, resilience, immunosupression, Immunologic diseases. Allergy, RC581-607
Abstract

ObjectiveIn severe cases of systemic sclerosis (SSc), autologous hematopoietic stem cell transplantation (aHSCT) is superior compared to cyclophosphamide. But treatment related morbidity and mortality have to be considered. To date, data on major physical and psychological impacts of aHSCT are scarce. Therefore, subjectively experienced physical and psychological impact of aHSCT and exploration of internal and external factors helping to cope with aHSCT was assessed.MethodsRetrospective assessment of physical and psychological variables in an SSc cohort after aHSCT to describe: Health-related quality of life (HRQL), SSc-associated impairment, coping strategies, body image, and resilience. Additionally, semi-structured interviews were conducted and analyzed via mixed methods qualitative content analysis.ResultsThirty-two patients were included. HRQL correlated with impairment due to SSc and with depressive coping. An unfavorable body image correlated with reduced HRQL and increased impairment but improves after aHSCT. Patients with good resilience had a better HRQL, less depressive coping, and less SSc-associated impairment. The semi-structured interviews revealed that resilience is important for a successful disease management as patients with higher resilience were more satisfied with aHSCT, patients with lower resilience would have wished for more psychological support. Thirty-one patients would recommend aHSCT to other patients.ConclusionA transient negative impact of aHSCT on mental well-being is present but can be relieved by a team specialized to aHSCT. Psychological support seems to be an unmet need, particularly in patients with low resilience. Patients with higher resilience described a lower negative impact caused by aHSCT and higher satisfaction after therapy.

Published
2024
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11. Synergy between multidimensional intellectual capital and digital knowledge management: Uncovering innovation performance complexities

Author

Sladjana Cabrilo, Sven Dahms, and Fu-Sheng Tsai

Subjects
O34, O30, History of scholarship and learning. The humanities, AZ20-999, Social sciences (General), H1-99
Abstract

This paper aims to deepen our understanding of the contingency and complex interrelations between multidimensional intellectual capital (IC), technology-based knowledge management (KM), and innovation outcomes in the rapidly changing business environment. More particularly, we investigate causal recipes for high innovation performance consisting of traditional IC components (human capital, structural capital, relational capital), the three more recently emerging IC dimensions (renewal capital, entrepreneurial capital, trust capital), and digital KM practices. This study adopts neo-configurational perspective and fuzzy-set qualitative comparative analysis (fsQCA) to explore multiple conjunctural causations of innovation performance using survey data collected from 102 publicly listed enterprises in Taiwan. Although the four identified archetypes (causal recipes) indicate that all IC dimensions and digital KM are potential collaborators contributing to high innovation performance, they also emphasize the critical role of digital KM in leveraging relational and trust capital for superior innovation performance. Human, structural, entrepreneurial, and renewal capital seems to be a supporting chorus for open and collaborative innovations in the digital era.

Published
2024
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12. Intra-lake origin and rapid expansion of invasive pelagic three-spined stickleback in Lake Constance

Author

Carolin Dahms, Samuel Roch, Kathryn R. Elmer, Albert Ros, Alexander Brinker, and Arne Jacobs

Subjects
Biology (General), QH301-705.5
Abstract

The rapid expansion of three-spined stickleback (Gasterosteus aculeatus Linnaeus, 1758 (Perciformes, Gasterosteida)) in the pelagic zone of Lake Constance, Central Europe, since 2012 contributed to stark ecosystem-wide effects, such as food-web shifts and declines in native biodiversity, including commercially important fish species. Yet, the origin of this invasive pelagic population remains unclear. Using RAD-sequencing of Lake Constance sticklebacks, we show that the pelagic Lake Constance population likely arose recently within the lake, potentially from the littoral population. We did not detect any substantial genome-wide genetic differentiation between individuals from different habitats, supporting a recent origin of the pelagic population and/or ongoing gene flow. This is further supported by minimal differences in meristic and morphometric traits. However, we also identified multiple outlier loci between littoral and pelagic individuals across the genome, potentially suggesting early signs of adaptation despite high connectivity. In this study, we provide an important example of rapid within-lake ecological diversification of an invasive species from standing genetic variation. Ultimately, our findings will have major implications for the management of invasive pelagic stickleback, as they indicate that the stickleback population has to be managed as a whole and that management efforts cannot only focus on the hyper-abundant pelagic population.

Published
2024
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18. A review of the environments, biota, and methods used in microplastics research in South Africa

Author

Heinrich T.J. Dahms and Richard Greenfield

Subjects
fresh water, marine, biota, Africa, plastics pollution, Science, Science (General), Q1-390, Social Sciences, Social sciences (General), H1-99
Abstract

Microplastics are small plastic materials often defined as those between 5 mm and 0.05 mm in size. Microplastics can have toxicological impacts on various biota, from gut blockages to the transport or leaching of toxicants used in their production or absorbed from the surrounding environment. Although microplastic research has increased significantly, microplastic research in Africa lags behind that of developed countries. South Africa is the African nation with the highest number of microplastic publications. We aimed to determine the current state of microplastic research in South Africa. A total of 46 publications on microplastics in South Africa have been produced. However, many of these publications use methods that might not be accurate in determining holistic descriptions of microplastics in the aquatic environment. Similarly, many ecologically relevant environments and species have not been investigated for microplastics in the country, including any atmospheric or terrestrial environment. We conclude that, although the research being produced in South Africa can be considered adequate, a singular standard method for sampling and assessing microplastics in South African environments is required. The production of such a standard method would be critical to use as a monitoring tool to determine and compare microplastic abundances across the country and globally. Significance: • More than 40 publications on microplastics have been produced in South Africa. • Microplastics have been discovered in multiple aquatic environments in South Africa, but have not been investigated in atmospheric or terrestrial environments. • Polymer analysis was limited in published research. • A standard method is required for comparing between studies. • Terrestrial and atmospheric microplastic studies are required.

Published
2024
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22. Using medical university websites for health education about COVID-19; an effective solution for public education during a pandemic

Author

Lina Cai, Jiwei Han, Zahra Aghalari, and Hans-Uwe Dahms‬

Subjects
Medical university, Website, Health education, COVID-19, Epidemiological prevention, Nutritional diseases. Deficiency diseases, RC620-627, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Medical universities use their websites to teach, research, and promote a culture of health. Therefore, this study aimed to evaluate the performance of medical universities in terms of health information and education regarding COVID-19 by surveying the website of Iranian medical universities. Methods This descriptive-analytical study was conducted in June to August 2020 on the websites of medical universities in three categories of universities (type 1, type 2 and type 3). The information of this study was collected from medical universities located in the east, west, north, south and center of Iran. Data were collected according to a checklist. The checklist contained 3 sections; the first part with 8 components regarding general information of the university websites, the second part with 11 components regarding the information and news related to the coronavirus and the third part with 12 components regarding the content of personal health education and environmental health for the prevention of coronavirus. To determine the status of each website in the two areas of health information and education, websites were divided into three categories based on scores (poor, average and good). Data were analyzed by chi-square. Results In this study, 1118 web pages related to 48 Iranian universities of medical sciences were reviewed, where 19 were type 1 universities, 21 type 2 universities, and 8 type 3 universities. The mean scores of the websites regarding the information and news related to the coronavirus (8.54 ± 1.750) and the mean scores of the websites regarding the personal and environmental health education related to coronavirus (10.96 ± 1.148) were in a favorable and positive condition. The ranking of medical universities by type showed that the scores in the two areas of health information and education about the coronavirus were in good condition and none of the universities were in bad condition. Chi-square showed that the information status and news related to the coronavirus had a significantly positive relationship with the type of medical universities (χ2 = 10.343, p = 0.006). Conclusions The results of this study showed that type1 and type 2 and 62.5% of type 3 medical universities were in good condition in terms of total scores in the two areas of health information and education about coronavirus and none of the universities were in a bad situation. It is suggested that the website of medical universities can serve as a reliable and appropriate source of information not only for academics and students but also for the general public.

Published
2023
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23. Connecting the dots: Motor and default mode network crossroads in post-stroke motor learning deficits

Author

Christiane Dahms, Alexander Noll, Franziska Wagner, Alexander Schmidt, Stefan Brodoehl, and Carsten M. Klingner

Subjects
Stroke, Functional connectivity, Resting state, Task-based, Motor learning, Recovery, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: Strokes frequently result in long-term motor deficits, imposing significant personal and economic burdens. However, our understanding of the underlying neural mechanisms governing motor learning in stroke survivors remains limited - a fact that poses significant challenges to the development and optimisation of therapeutic strategies. Objective: This study investigates the diversity in motor learning aptitude and its associated neurological mechanisms. We hypothesised that stroke patients exhibit compromised overall motor learning capacity, which is associated with altered activity and connectivity patterns in the motor- and default-mode-network in the brain. Methods: We assessed a cohort of 40 chronic-stage, mildly impaired stroke survivors and 39 age-matched healthy controls using functional Magnetic Resonance Imaging (fMRI) and connectivity analyses. We focused on neural activity and connectivity patterns during an unilateral motor sequence learning task performed with the unimpaired or non-dominant hand. Primary outcome measures included task-induced changes in neural activity and network connectivity. Results: Compared to controls, stroke patients showed significantly reduced motor learning capacity, associated with diminished cerebral lateralization. Task induced activity modulation was reduced in the motor network but increased in the default mode network. The modulated activation strength was associated with an opposing trend in task-induced functional connectivity, with increased connectivity in the motor network and decreased connectivity in the DMN. Conclusions: Stroke patients demonstrate altered neural activity and connectivity patterns during motor learning with their unaffected hand, potentially contributing to globally impaired motor learning skills. The reduced ability to lateralize cerebral activation, along with the enhanced connectivity between the right and left motor cortices in these patients, may signify maladaptive neural processes that impede motor adaptation, possibly affecting long-term rehabilitation post-stroke. The contrasting pattern of activity modulation and connectivity alteration in the default mode network suggests a nuanced role of this network in post-stroke motor learning. These insights could have significant implications for the development of customised rehabilitation strategies for stroke patients.

Published
2024
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26. Structural characterization, antioxidant and anti-uropathogenic potential of biogenic silver nanoparticles using brown seaweed Turbinaria ornata

Author

C. T. Dhanya Raj, Krishnan Muthukumar, Hans Uwe Dahms, Rathinam Arthur James, and Surabhi Kandaswamy

Subjects
silver nanoparticles, uropathogens, urinary tract infections, T. ornata, antioxidant, anti-uropathogenic, Microbiology, QR1-502
Abstract

Alternative treatment strategies for urinary tract infections (UTIs) are becoming more necessary due to increasing drug resistance patterns in uropathogens. Nanoparticle-based therapeutics is emerging as a way to treat UTIs. In the present study, using Turbinaria ornata extract, silver nanoparticles (AgNPs) were synthesized, characterized, and their anti-uropathogenic activity was evaluated. The stability and formation of synthesized To-AgNPs were confirmed by UV-visible spectroscopy, FTIR, XRD, SEM, and DLS. An FTIR spectrum confirmed the presence of seaweed functional groups in To-AgNPs, a XRD analysis confirmed their crystalline nature, and SEM imaging confirmed their spherical nature with an average size of 73.98 nm with diameters ranging from 64.67 to 81.28 nm. This was confirmed by TEM results. DLS determined that the cumulant hydrodynamic diameter of To-AgNPs was 128.3 nm with a PdI of 0.313 and the zeta potential value were found to be –63.3 mV which indicates the To-AgNPs are negatively charged and more stable. DPPH assays were used to assess the antioxidant activity of biosynthesized To-AgNPs, while an agar well diffusion method was used to test the antibacterial activity against uropathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, and Klebsiella pneumoniae. The To-AgNPs showed the highest susceptibility to S. aureus (15.75 ± 0.35 mm) and E. coli (15 ± 0.7 mm) with MIC values of 0.0625 and 0.125 mg/ml, respectively in macro broth dilution method and observed considerable membrane damage under CLSM and SEM. To-AgNPs displayed stronger antioxidant and antimicrobial activity, suggesting they may be developed as a new class of antimicrobial agents for treating UTIs.

Published
2023
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27. Anakinra for the treatment of COVID-19 patients: a systematic review and meta-analysis

Author

Karolina Dahms, Agata Mikolajewska, Kelly Ansems, Maria-Inti Metzendorf, Carina Benstoem, and Miriam Stegemann

Subjects
Anakinra, Interleukin 1 receptor antagonist protein, SARS-CoV-2, Hospitalization, Meta-analysis, Systematic review, Medicine
Abstract

Abstract Background At the end of 2021, the European Medicines Agency (EMA) expanded its approval for the recombinant human interleukin-1 (IL-1) receptor antagonist Anakinra for the treatment of COVID-19 patients with elevated soluble urokinase plasminogen activator receptor (suPAR). However, the role of Anakinra in COVID-19 remains unanswered, especially in patients receiving different forms of respiratory support. Therefore, the objective of this systematic review is to assess the safety and effects of Anakinra compared to placebo or standard care alone on clinical outcomes in adult hospitalized patients with SARS-CoV-2 infection. Methods We searched the Cochrane COVID-19 Study Register (comprising MEDLINE, Embase, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, medRxiv, and the Cochrane Central Register of Controlled Trials (CCSR)) and the WHO COVID-19 Global literature on coronavirus disease database to identify completed and ongoing studies from inception of each database to December 13, 2021. Since then, we monitored new published studies weekly up to June 30, 2022 using the CCSR. We included RCTs comparing treatment with Anakinra to placebo or standard care alone in adult hospitalized patients with SARS-CoV-2 infection. Results We included five RCTs with 1,627 patients (n Anakinra = 888, n control = 739, mean age 59.63 years, 64% male). Random-effects meta-analysis was used to pool data. We found that Anakinra makes little or no difference to all-cause mortality at up to day 28 compared to placebo or standard care alone (RR 0.96, 95% CI 0.64–1.45; RD 9 fewer per 1000, 95% CI 84 fewer to 104 more; 4 studies, 1593 participants; I 2 = 49%; low certainty of evidence). Conclusions Anakinra has no effect on adult hospitalized patients with SARS-CoV-2 infection regarding mortality, clinical improvement and worsening as well as on safety outcomes compared to placebo or standard care alone. Trial Registration: PROSPERO Registration Number: CRD42021257552.

Published
2023
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28. Food hygiene research: a bibliometric comparison in Iranian and international 'Environmental Health' journals

Author

Zahra Aghalari, Hans-Uwe Dahms, and Mika Sillanpää

Subjects
Food hygiene, Community health, Environmental health, Journals, Nutritional diseases. Deficiency diseases, RC620-627, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Food hygiene is one of the specialized fields of environmental health, and despite the problems associated with foodborne illnesses, there is no evaluation available that would focus on specialized environmental health journals. The purpose of the present survey is a comparison of the status of food hygiene articles published in Iranian and international journals of environmental health. Methods This cross-sectional descriptive study was performed on all published articles in five Iranian environmental health journals and three international environmental health journals that are among the top 5% and 10% based on SNIP, emphasizing the issue of food. Our data were collected by searching relevant keywords in the articles published during the years (2008–2021), with emphasis on food hygiene. In the checklist, journal and articles information was collected by year of publication, a number of articles, information on authors' participation status in terms of number, gender, organizational affiliation, country and continents, and research centers according to authors' authorship. Statistical analysis of data was performed using descriptive and inferential statistical indices. VOSviewer software was also used to visualize the data. Results In Iranian environmental health journals, out of 2305 articles (7.3%) and out of 6898 articles in international environmental health journals (2.4%) dealt with food hygiene. Food hygiene articles were divided into seven categories, with the largest number of articles on aquatic and agricultural products each with a frequency of 48 articles. Articles related to heavy metals in food were provided by 30.81%. In this study, out of 150 articles, 15 articles were written with the participation of 30 authors from seven continents (Asia, America, and Europe), most of which were from Asia and India. In international environmental health journals, among the main research topics in articles related to food hygiene, the highest number (52.5%) was related to a determination about pollution such as heavy metal concentrations in food. Conclusions Articles published in Iranian and international environmental health journals about food hygiene were limited. According to the increasing prevalence of foodborne illnesses, especially in recent decades, and the importance of paying attention to food hygiene, more targeted studies are needed.

Published
2023
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29. Protistan epibionts affect prey selectivity patterns and vulnerability to predation in a cyclopoid copepod

Author

Ram Kumar, Suman Kumari, Anshu Malika, A. P. Sharma, and Hans-Uwe Dahms

Subjects
Medicine, Science
Abstract

Abstract Colonisation of crustacean zooplankton with ciliate epibionts is widespread in freshwater and marine environments. However, the ecology of such association are little studied as yet. The occurrence of ciliate epibionts on copepods and the preference towards this association with different life stages of Mesocyclops were studied from winter to spring. Relative susceptibility of zooplankton species was evaluated by analysing the epibiont colonies and zooids and relate this to the surface area of the host. The maximum epibiont infestation per unit body surface area was recorded on copepodites followed by copepod nauplii rather than other zooplankton species, whereas the rotifer Asplanchna was never affected. Influence of climatic factors such as temperature on the colonisation of epibionts on basibionts was found significant. In winter (November to February) samples, copepods were infested by autotrophic epibionts whereas in late spring and early summer (March–April) heterotrophic protists (peritrichian ciliates) were the sole epibionts on copepods. We conducted experiments in the laboratory on prey selection pattern of predators by direct visual and video-graphic observations of various events (encounter, attack, capture, ingestion, prey escape) during predation by infested and uninfested copepodites and adults of Mesocyclops. Postencounter the attack probability was significantly lower in infested than in uninfested copepods. The present paper reports on substrate preference by epibionts and their impacts in food rich and food scarce environments. Furthermore, major environmental interactions were studied with the reproductive phenology of copepods with respect to epibionts and the cause and effect of long term association of epibionts with copepods need to be addressed.

Published
2022
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31. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author

The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. 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Bachmair, L. Bäni, P. Bortignon, M. A. Buchmann, B. Casal, N. Chanon, A. Deisher, G. Dissertori, M. Dittmar, M. Donegà, M. Dünser, P. Eller, K. Freudenreich, C. Grab, D. Hits, P. Lecomte, W. Lustermann, A. C. Marini, P. Martinez Ruiz del Arbol, N. Mohr, F. Moortgat, C. Nägeli, P. Nef, F. Nessi-Tedaldi, F. Pandolfi, L. Pape, F. Pauss, M. Peruzzi, F. J. Ronga, M. Rossini, L. Sala, A. K. Sanchez, A. Starodumov, B. Stieger, M. Takahashi, L. Tauscher, A. Thea, K. Theofilatos, D. Treille, C. Urscheler, R. Wallny, H. A. Weber, C. Amsler, V. Chiochia, C. Favaro, M. Ivova Rikova, B. Kilminster, B. Millan Mejias, P. Otiougova, P. Robmann, H. Snoek, S. Taroni, S. Tupputi, M. Verzetti, M. Cardaci, K. H. Chen, C. Ferro, C. M. Kuo, S. W. Li, W. Lin, Y. J. Lu, R. Volpe, S. S. Yu, P. Bartalini, P. Chang, Y. H. Chang, Y. W. Chang, Y. Chao, K. F. Chen, C. Dietz, U. Grundler, W.-S. Hou, Y. Hsiung, K. Y. Kao, Y. J. Lei, R.-S. Lu, D. Majumder, E. Petrakou, X. Shi, J. G. Shiu, Y. M. Tzeng, M. Wang, B. Asavapibhop, N. Srimanobhas, A. Adiguzel, M. N. Bakirci, S. Cerci, C. Dozen, I. Dumanoglu, E. Eskut, S. Girgis, G. Gokbulut, E. Gurpinar, I. Hos, E. E. Kangal, A. Kayis Topaksu, G. Onengut, K. Ozdemir, S. Ozturk, A. Polatoz, K. Sogut, D. Sunar Cerci, B. Tali, H. Topakli, M. Vergili, I. V. Akin, T. Aliev, B. Bilin, S. Bilmis, M. Deniz, H. Gamsizkan, A. M. Guler, G. Karapinar, K. Ocalan, A. Ozpineci, M. Serin, R. Sever, U. E. Surat, M. Yalvac, M. Zeyrek, E. Gülmez, B. Isildak, M. Kaya, O. Kaya, S. Ozkorucuklu, N. Sonmez, H. Bahtiyar, E. Barlas, K. Cankocak, Y. O. Günaydin, F. I. Vardarli, M. Yücel, L. Levchuk, P. Sorokin, J. J. Brooke, E. Clement, D. Cussans, H. Flacher, R. Frazier, J. Goldstein, M. Grimes, G. P. Heath, H. F. Heath, L. Kreczko, S. Metson, D. M. Newbold, K. Nirunpong, A. Poll, S. Senkin, V. J. Smith, T. Williams, L. Basso, K. W. Bell, C. Brew, R. M. Brown, D. J. A. Cockerill, J. A. Coughlan, K. Harder, S. Harper, J. Jackson, E. Olaiya, D. Petyt, B. C. Radburn-Smith, C. H. Shepherd-Themistocleous, I. R. Tomalin, W. J. Womersley, R. Bainbridge, O. Buchmuller, D. Burton, D. Colling, N. Cripps, M. Cutajar, P. Dauncey, G. Davies, M. Della Negra, W. Ferguson, J. Fulcher, D. Futyan, A. Gilbert, A. Guneratne Bryer, G. Hall, Z. Hatherell, J. Hays, G. Iles, M. Jarvis, G. Karapostoli, M. Kenzie, R. Lane, R. Lucas, L. Lyons, A.-M. Magnan, J. Marrouche, B. Mathias, R. Nandi, J. Nash, A. Nikitenko, J. Pela, M. Pesaresi, K. Petridis, M. Pioppi, D. M. Raymond, S. Rogerson, A. Rose, C. Seez, P. Sharp, A. Sparrow, A. Tapper, M. Vazquez Acosta, T. Virdee, S. Wakefield, N. Wardle, T. Whyntie, M. Chadwick, J. E. Cole, P. R. Hobson, A. Khan, P. Kyberd, D. Leggat, D. Leslie, W. Martin, I. D. Reid, P. Symonds, L. Teodorescu, M. Turner, J. Dittmann, K. Hatakeyama, A. Kasmi, H. Liu, T. Scarborough, O. Charaf, S. I. Cooper, C. Henderson, P. Rumerio, A. Avetisyan, T. Bose, C. Fantasia, A. Heister, P. Lawson, D. Lazic, J. Rohlf, D. Sperka, J. St. John, L. Sulak, J. Alimena, G. Christopher, D. Cutts, Z. Demiragli, A. Ferapontov, A. Garabedian, U. Heintz, G. Kukartsev, E. Laird, G. Landsberg, M. Luk, M. Narain, M. Segala, T. Sinthuprasith, T. Speer, R. Breedon, G. Breto, M. Calderon De La Barca Sanchez, S. Chauhan, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, M. Gardner, R. Houtz, W. Ko, A. Kopecky, R. Lander, O. Mall, T. Miceli, R. Nelson, D. Pellett, F. Ricci-Tam, B. Rutherford, M. Searle, J. Smith, M. Squires, M. Tripathi, S. Wilbur, R. Yohay, D. Cline, R. Cousins, S. Erhan, P. Everaerts, C. Farrell, M. Felcini, J. Hauser, M. Ignatenko, C. Jarvis, G. Rakness, P. Schlein, E. Takasugi, P. Traczyk, V. Valuev, J. Babb, R. Clare, M. E. Dinardo, J. Ellison, J. W. Gary, G. Hanson, O. R. Long, A. Luthra, H. Nguyen, S. Paramesvaran, J. Sturdy, S. Sumowidagdo, R. Wilken, S. Wimpenny, W. Andrews, J. G. Branson, G. B. Cerati, S. Cittolin, D. Evans, A. Holzner, R. Kelley, M. Lebourgeois, J. Letts, I. Macneill, B. Mangano, S. Padhi, C. Palmer, G. Petrucciani, M. Pieri, M. Sani, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flowers, P. Geffert, C. George, F. Golf, J. Incandela, C. Justus, P. Kalavase, D. Kovalskyi, V. Krutelyov, S. Lowette, R. Magaña Villalba, N. Mccoll, V. Pavlunin, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, C. West, A. Apresyan, A. Bornheim, J. Bunn, Y. Chen, E. Di Marco, J. Duarte, D. Kcira, Y. Ma, A. Mott, H. B. Newman, C. Rogan, M. Spiropulu, V. Timciuc, J. Veverka, R. Wilkinson, S. Xie, Y. Yang, R. Y. Zhu, V. Azzolini, A. Calamba, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, Y. F. Liu, M. Paulini, J. Russ, H. Vogel, I. Vorobiev, J. P. Cumalat, B. R. Drell, W. T. Ford, A. Gaz, E. Luiggi Lopez, U. Nauenberg, J. G. Smith, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, A. Chatterjee, N. Eggert, L. K. Gibbons, W. Hopkins, A. Khukhunaishvili, B. Kreis, N. Mirman, G. Nicolas Kaufman, J. R. Patterson, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Tucker, Y. Weng, L. Winstrom, P. Wittich, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, V. D. Elvira, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, L. Gray, D. Green, O. Gutsche, D. Hare, R. M. Harris, J. Hirschauer, B. Hooberman, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, J. Linacre, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, V. I. Martinez Outschoorn, S. Maruyama, D. Mason, P. McBride, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, O. Prokofyev, N. Ratnikova, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, R. Remington, A. Rinkevicius, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, F. Yumiceva, M. R. Adams, L. Apanasevich, V. E. Bazterra, R. R. Betts, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, P. Kurt, F. Lacroix, D. H. Moon, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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32. Evaluating different web applications to assess the toxicity of plasticizers

Author

Charli Deepak Arulanandam, Jiang-Shiou Hwang, Arthur James Rathinam, and Hans-Uwe Dahms

Subjects
Medicine, Science
Abstract

Abstract Plasticizers increase the flexibility of plastics. As environmental leachates they lead to increased water and soil pollution, as well as to serious harm to human health. This study was set out to explore various web applications to predict the toxicological properties of plasticizers. Web-based tools (e.g., BOILED-Egg, LAZAR, PROTOX-II, CarcinoPred-EL) and VEGA were accessed via an 5th–10th generation computer in order to obtain toxicological predictions. Based on the LAZAR mutagenicity assessment was only bisphenol F predicted as mutagenic. The BBP and DBP in RF; DEHP in RF and XGBoost; DNOP in RF and XGBoost models were predicted as carcinogenic in the CarcinoPred-EL web application. From the bee predictive model (KNN/IRFMN) BPF, di-n-propyl phthalate, diallyl phthalate, dibutyl phthalate, and diisohexyl phthalate were predicted as strong bee toxicants. Acute toxicity for fish using the model Sarpy/IRFMN predicted 19 plasticizers as strong toxicants with LC50 values of less than 1 mg/L. This study also considered plasticizer effects on gastrointestinal absorption and other toxicological endpoints.

Published
2022
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33. Evaluation of nutrients in bread: a systematic review

Author

Zahra Aghalari, Hans-Uwe Dahms, and Mika Sillanpää

Subjects
Nutrients, Bread, Food hygiene, Environmental health, Nutrition, Nutritional diseases. Deficiency diseases, RC620-627, Public aspects of medicine, RA1-1270
Abstract

Abstract Background A balanced and optimized amount of nutrients in bread, which is the main food in many countries, is necessary to maintain human health. Considering the importance of nutritional values of bread in the food basket of Iranian households, the purpose of this study was to determine the nutrients and their concentrations in breads consumed in Iran. Methods This systematic review study was performed to determine the types of nutrients in breads consumed in Iran by searching reputable international databases including Scopus and Google scholar, PubMed, Science direct, ISI (Web of Science). Data were collected according to inclusion and exclusion criteria and by searching for relevant keywords, emphasizing the types of nutrients in breads consumed in Iran. Qualitative data were collected using the standard PRISMA checklist (preferential reporting items for systematic reviews and meta-analysis). After verifying the quality of the articles, the information was entered into a checklist such as the name of the first author and year of publication of the research, type of study, number of samples, type of nutrition, type of bread and amount of nutrition measured. Results After reviewing the information and quality of articles, 10 articles were qualified for systematic review. The review of the articles showed that different breads were experimented, including: Sangak, Barbari, Taftoon, Lavash, French and local bread. The highest number of experimented bread samples was Sangak. Examination of the articles showed that 6 nutrients were experimented in different breads such as Fe, K, Mg, Ca, Cu and Zn. The highest number of experimented in breads was related to the amount of Zn (13 times) and Cu (10 times), respectively. The results of quality assessment of articles showed that most of the studies were of good quality. The results of articles on the amount of nutrients measured in different breads showed that only in two articles the amount of nutrients was reported to be desirable. In most articles, the amount of nutrients in breads was reported to be lower or higher than standard. Conclusion The results of this study showed that the concentration of nutrients in most articles was undesirable. It is suggested that optimal methods of enrichment of breads and flours be done with interdisciplinary cooperation between food hygiene, environmental health, nutrition, farmers and bakers. It is recommended that food hygiene and environmental health researchers investigate other nutrients (including phosphorus, selenium, manganese, boron and molybdenum) in breads and other staple foods used by people to constructive and practical measures to increase public health.

Published
2022
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34. A Simple and Reproducible Stereomicroscopic Method to Assess Fungal Biofilms: Application to Antifungal Susceptibility Testing

Author

Zinnat Shahina and Tanya Dahms

Subjects
Biology (General), QH301-705.5
Abstract

Candida albicans, a well-known opportunistic pathogen, is a major cause of human fungal infections. Biofilm formation is considered an important pathogenesis factor. Biofilms are less sensitive to antibiotics and immune responses, allowing them to colonize and persist in host niches. Biofilm screening is important in the identification of anti-biofilm drugs. However, developing nations, with limited financial resources, often do not have access to advanced scientific equipment. Here, we describe an in vitro, protocol using common materials and simple equipment to evaluate static microbial biofilms.

Published
2023
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35. Neurofeedback therapy to improve cognitive function in patients with chronic post-stroke attention deficits: a within-subjects comparison

Author

Sonja C. Kleih-Dahms and Loic Botrel

Subjects
stroke, slow cortical potentials (SCP), attention deficit, neurofeedback training, self-efficacy, brain-computer interfaces (BCI), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

IntroductionWe investigated a slow-cortical potential (SCP) neurofeedback therapy approach for rehabilitating chronic attention deficits after stroke. This study is the first attempt to train patients who survived stroke with SCP neurofeedback therapy.MethodsWe included N = 5 participants in a within-subjects follow-up design. We assessed neuropsychological and psychological performance at baseline (4 weeks before study onset), before study onset, after neurofeedback training, and at 3 months follow-up. Participants underwent 20 sessions of SCP neurofeedback training.ResultsParticipants learned to regulate SCPs toward negativity, and we found indications for improved attention after the SCP neurofeedback therapy in some participants. Quality of life improved throughout the study according to engagement in activities of daily living. The self-reported motivation was related to mean SCP activation in two participants.DiscussionWe would like to bring attention to the potential of SCP neurofeedback therapy as a new rehabilitation method for treating post-stroke cognitive deficits. Studies with larger samples are warranted to corroborate the results.

Published
2023
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36. Carvacrol-Induced Vacuole Dysfunction and Morphological Consequences in Nakaseomyces glabratus and Candida albicans

Author

Eliz Acuna, Easter Ndlovu, Ali Molaeitabari, Zinnat Shahina, and Tanya Elizabeth Susan Dahms

Subjects
carvacrol, hyphae, pH, membrane integrity, morphogenesis, vacuole, Biology (General), QH301-705.5
Abstract

With the prevalence of systemic fungal infections caused by Candida albicans and non-albicans species and their resistance to classical antifungals, there is an urgent need to explore alternatives. Herein, we evaluate the impact of the monoterpene carvacrol, a major component of oregano and thyme oils, on clinical and laboratory strains of C. albicans and Nakaseomyces glabratus. Carvacrol induces a wide range of antifungal effects, including the inhibition of growth and hyphal and biofilm formation. Using biochemical and microscopic approaches, we elucidate carvacrol-induced hyphal inhibition. The significantly reduced survival rates following exposure to carvacrol were accompanied by dose-dependent vacuolar acidification, disrupted membrane integrity, and aberrant morphology. Germ tube assays, used to elucidate the relationship between vacuolar dysfunction and hyphal inhibition, showed that carvacrol significantly reduced hyphal formation, which was accompanied by a defective C. albicans morphology. Thus, we show a link between vacuolar acidification/disrupted vacuole membrane integrity and compromised candidal morphology/morphogenesis, demonstrating that carvacrol exerts its anti-hyphal activity by altering vacuole integrity.

Published
2023
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42. Erratum to: Searches for long-lived charged particles in pp collisions at s = 7 and 8 TeV

Author

Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Krätschmer, I., Liko, D., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C.-E., Mossolov, V., Shumeiko, N., Suarez Gonzalez, J., Alderweireldt, S., Bansal, M., Bansal, S., Cornelis, T., De Wolf, E. A., Janssen, X., Knutsson, A., Luyckx, S., Mucibello, L., Ochesanu, S., Roland, B., Rougny, R., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Blekman, F., Blyweert, S., D’Hondt, J., Kalogeropoulos, A., Keaveney, J., Maes, M., Olbrechts, A., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G. P., Villella, I., Clerbaux, B., De Lentdecker, G., Favart, L., Gay, A. P. R., Hreus, T., Léonard, A., Marage, P. E., Mohammadi, A., Perniè, L., Reis, T., Seva, T., Thomas, L., Vander Velde, C., Vanlaer, P., Wang, J., Adler, V., Beernaert, K., Benucci, L., Cimmino, A., Costantini, S., Dildick, S., Garcia, G., Klein, B., Lellouch, J., Marinov, A., Mccartin, J., Ocampo Rios, A. A., Ryckbosch, D., Sigamani, M., Strobbe, N., Thyssen, F., Tytgat, M., Walsh, S., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bruno, G., Castello, R., Caudron, A., Ceard, L., Delaere, C., du Pree, T., Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jez, P., Lemaitre, V., Liao, J., Militaru, O., Nuttens, C., Pagano, D., Pin, A., Piotrzkowski, K., Popov, A., Selvaggi, M., Vizan Garcia, J. M., Beliy, N., Caebergs, T., Daubie, E., Hammad, G. H., Alves, G. A., Correa Martins Junior, M., Martins, T., Pol, M. E., Souza, M. H. G., Aldá Júnior, W. L., Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E. M., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Malbouisson, H., Malek, M., Matos Figueiredo, D., Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Bernardes, C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, C., Marinho, F., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Genchev, V., Iaydjiev, P., Piperov, S., Rodozov, M., Sultanov, G., Vutova, M., Dimitrov, A., Hadjiiska, R., Kozhuharov, V., Litov, L., Pavlov, B., Petkov, P., Bian, J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, D., Liang, S., Meng, X., Tao, J., Wang, J., Wang, X., Wang, Z., Xiao, H., Xu, M., Asawatangtrakuldee, C., Ban, Y., Guo, Y., Li, W., Liu, S., Mao, Y., Qian, S. J., Teng, H., Wang, D., Zhang, L., Zou, W., Avila, C., Carrillo Montoya, C. A., Gomez, J. P., Gomez Moreno, B., Sanabria, J. C., Godinovic, N., Lelas, D., Plestina, R., Polic, D., Puljak, I., Antunovic, Z., Kovac, M., Brigljevic, V., Duric, S., Kadija, K., Luetic, J., Mekterovic, D., Morovic, S., Tikvica, L., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Finger, M., Finger, Jr., M., Assran, Y., Ellithi Kamel, A., Mahmoud, M. A., Mahrous, A., Radi, A., Kadastik, M., Müntel, M., Murumaa, M., Raidal, M., Rebane, L., Tiko, A., Eerola, P., Fedi, G., Voutilainen, M., Härkönen, J., Karimäki, V., Kinnunen, R., Kortelainen, M. J., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Luukka, P., Mäenpää, T., Peltola, T., Tuominen, E., Tuominiemi, J., Tuovinen, E., Wendland, L., Korpela, A., Tuuva, T., Besancon, M., Choudhury, S., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Hamel de Monchenault, G., Jarry, P., Locci, E., Malcles, J., Millischer, L., Nayak, A., Rander, J., Rosowsky, A., Titov, M., Baffioni, S., Beaudette, F., Benhabib, L., Bianchini, L., Bluj, M., Busson, P., Charlot, C., Daci, N., Dahms, T., Dalchenko, M., Dobrzynski, L., Florent, A., Granier de Cassagnac, R., Haguenauer, M., Miné, P., Mironov, C., Naranjo, I. N., Nguyen, M., Ochando, C., Paganini, P., Sabes, D., Salerno, R., Sirois, Y., Veelken, C., Zabi, A., Agram, J.-L., Andrea, J., Bloch, D., Bodin, D., Brom, J.-M., Chabert, E. C., Collard, C., Conte, E., Drouhin, F., Fontaine, J.-C., Gelé, D., Goerlach, U., Goetzmann, C., Juillot, P., Le Bihan, A.-C., Van Hove, P., Gadrat, S., Beauceron, S., Beaupere, N., Boudoul, G., Brochet, S., Chasserat, J., Chierici, R., Contardo, D., Depasse, P., El Mamouni, H., Fay, J., Gascon, S., Gouzevitch, M., Ille, B., Kurca, T., Lethuillier, M., Mirabito, L., Perries, S., Sgandurra, L., Sordini, V., Tschudi, Y., Vander Donckt, M., Verdier, P., Viret, S., Tsamalaidze, Z., Autermann, C., Beranek, S., Calpas, B., Edelhoff, M., Feld, L., Heracleous, N., Hindrichs, O., Klein, K., Ostapchuk, A., Perieanu, A., Raupach, F., Sammet, J., Schael, S., Sprenger, D., Weber, H., Wittmer, B., Zhukov, V., Ata, M., Caudron, J., Dietz-Laursonn, E., Duchardt, D., Erdmann, M., Fischer, R., Güth, A., Hebbeker, T., Heidemann, C., Hoepfner, K., Klingebiel, D., Kreuzer, P., Merschmeyer, M., Meyer, A., Olschewski, M., Padeken, K., Papacz, P., Pieta, H., Reithler, H., Schmitz, S. A., Sonnenschein, L., Steggemann, J., Teyssier, D., Thüer, S., Weber, M., Cherepanov, V., Erdogan, Y., Flügge, G., Geenen, H., Geisler, M., Haj Ahmad, W., Hoehle, F., Kargoll, B., Kress, T., Kuessel, Y., Lingemann, J., Nowack, A., Nugent, I. M., Perchalla, L., Pooth, O., Stahl, A., Aldaya Martin, M., Asin, I., Bartosik, N., Behr, J., Behrenhoff, W., Behrens, U., Bergholz, M., Bethani, A., Borras, K., Burgmeier, A., Cakir, A., Calligaris, L., Campbell, A., Costanza, F., Diez Pardos, C., Dooling, S., Dorland, T., Eckerlin, G., Eckstein, D., Flucke, G., Geiser, A., Glushkov, I., Gunnellini, P., Habib, S., Hauk, J., Hellwig, G., Jung, H., Kasemann, M., Katsas, P., Kleinwort, C., Kluge, H., Krämer, M., Krücker, D., Kuznetsova, E., Lange, W., Leonard, J., Lipka, K., Lohmann, W., Lutz, B., Mankel, R., Marfin, I., Melzer-Pellmann, I.-A., Meyer, A. B., Mnich, J., Mussgiller, A., Naumann-Emme, S., Novgorodova, O., Nowak, F., Olzem, J., Perrey, H., Petrukhin, A., Pitzl, D., Placakyte, R., Raspereza, A., Ribeiro Cipriano, P. M., Riedl, C., Ron, E., Sahin, M. Ö., Salfeld-Nebgen, J., Schmidt, R., Schoerner-Sadenius, T., Sen, N., Stein, M., Walsh, R., Wissing, C., Blobel, V., Enderle, H., Erfle, J., Gebbert, U., Görner, M., Gosselink, M., Haller, J., Heine, K., Höing, R. S., Kaussen, G., Kirschenmann, H., Klanner, R., Kogler, R., Lange, J., Marchesini, I., Peiffer, T., Pietsch, N., Rathjens, D., Sander, C., Schettler, H., Schleper, P., Schlieckau, E., Schmidt, A., Schröder, M., Schum, T., Seidel, M., Sibille, J., Sola, V., Stadie, H., Steinbrück, G., Thomsen, J., Troendle, D., Vanelderen, L., Barth, C., Baus, C., Berger, J., Böser, C., Chwalek, T., De Boer, W., Descroix, A., Dierlamm, A., Feindt, M., Guthoff, M., Hackstein, C., Hartmann, F., Hauth, T., Heinrich, M., Held, H., Hoffmann, K. H., Husemann, U., Katkov, I., Komaragiri, J. R., Kornmayer, A., Lobelle Pardo, P., Martschei, D., Mueller, S., Müller, Th., Niegel, M., Nürnberg, A., Oberst, O., Ott, J., Quast, G., Rabbertz, K., Ratnikov, F., Röcker, S., Schilling, F.-P., Schott, G., Simonis, H. J., Stober, F. M., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weiler, T., Zeise, M., Anagnostou, G., Daskalakis, G., Geralis, T., Kesisoglou, S., Kyriakis, A., Loukas, D., Markou, A., Markou, C., Ntomari, E., Gouskos, L., Mertzimekis, T. J., Panagiotou, A., Saoulidou, N., Stiliaris, E., Aslanoglou, X., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Manthos, N., Papadopoulos, I., Paradas, E., Bencze, G., Hajdu, C., Hidas, P., Horvath, D., Radics, B., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Molnar, J., Palinkas, J., Szillasi, Z., Karancsi, J., Raics, P., Trocsanyi, Z. L., Ujvari, B., Beri, S. B., Bhatnagar, V., Dhingra, N., Gupta, R., Kaur, M., Mehta, M. Z., Mittal, M., Nishu, N., Saini, L. K., Sharma, A., Singh, J. B., Kumar, Ashok, Kumar, Arun, Ahuja, S., Bhardwaj, A., Choudhary, B. C., Malhotra, S., Naimuddin, M., Ranjan, K., Saxena, P., Sharma, V., Shivpuri, R. K., Banerjee, S., Bhattacharya, S., Chatterjee, K., Dutta, S., Gomber, B., Jain, Sa., Jain, Sh., Khurana, R., Modak, A., Mukherjee, S., Roy, D., Sarkar, S., Sharan, M., Abdulsalam, A., Dutta, D., Kailas, S., Kumar, V., Mohanty, A. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Chatterjee, R. M., Ganguly, S., Ghosh, S., Guchait, M., Gurtu, A., Kole, G., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Mohanty, G. B., Parida, B., Sudhakar, K., Wickramage, N., Banerjee, S., Dugad, S., Arfaei, H., Bakhshiansohi, H., Etesami, S. M., Fahim, A., Hesari, H., Jafari, A., Khakzad, M., Mohammadi Najafabadi, M., Paktinat Mehdiabadi, S., Safarzadeh, B., Zeinali, M., Grunewald, M., Abbrescia, M., Barbone, L., Calabria, C., Chhibra, S. S., Colaleo, A., Creanza, D., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., Marangelli, B., My, S., Nuzzo, S., Pacifico, N., Pompili, A., Pugliese, G., Selvaggi, G., Silvestris, L., Singh, G., Venditti, R., Verwilligen, P., Zito, G., Abbiendi, G., Benvenuti, A. C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Meneghelli, M., Montanari, A., Navarria, F. L., Odorici, F., Perrotta, A., Primavera, F., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Travaglini, R., Albergo, S., Chiorboli, M., Costa, S., Giordano, F., Potenza, R., Tricomi, A., Tuve, C., Barbagli, G., Ciulli, V., Civinini, C., D’Alessandro, R., Focardi, E., Frosali, S., Gallo, E., Gonzi, S., Gori, V., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Tropiano, A., Benussi, L., Bianco, S., Fabbri, F., Piccolo, D., Fabbricatore, P., Musenich, R., Tosi, S., Benaglia, A., De Guio, F., Di Matteo, L., Fiorendi, S., Gennai, S., Ghezzi, A., Govoni, P., Lucchini, M. T., Malvezzi, S., Manzoni, R. A., Martelli, A., Menasce, D., Moroni, L., Paganoni, M., Pedrini, D., Ragazzi, S., Redaelli, N., Tabarelli de Fatis, T., Buontempo, S., Cavallo, N., De Cosa, A., Fabozzi, F., Iorio, A. O. M., Lista, L., Meola, S., Merola, M., Paolucci, P., Azzi, P., Bacchetta, N., Bisello, D., Branca, A., Carlin, R., Checchia, P., Dorigo, T., Dosselli, U., Galanti, M., Gasparini, F., Gasparini, U., Giubilato, P., Gozzelino, A., Gulmini, M., Kanishchev, K., Lacaprara, S., Lazzizzera, I., Margoni, M., Maron, G., Meneguzzo, A. T., Pazzini, J., Pozzobon, N., Ronchese, P., Simonetto, F., Torassa, E., Tosi, M., Vanini, S., Zotto, P., Zucchetta, A., Zumerle, G., Gabusi, M., Ratti, S. P., Riccardi, C., Vitulo, P., Biasini, M., Bilei, G. M., Fanò, L., Lariccia, P., Mantovani, G., Menichelli, M., Nappi, A., Romeo, F., Saha, A., Santocchia, A., Spiezia, A., Androsov, K., Azzurri, P., Bagliesi, G., Boccali, T., Broccolo, G., Castaldi, R., D’Agnolo, R. T., Dell’Orso, R., Fiori, F., Foà, L., Giassi, A., Kraan, A., Ligabue, F., Lomtadze, T., Martini, L., Messineo, A., Palla, F., Rizzi, A., Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Vernieri, C., Barone, L., Cavallari, F., Del Re, D., Diemoz, M., Grassi, M., Longo, E., Margaroli, F., Meridiani, P., Micheli, F., Nourbakhsh, S., Organtini, G., Paramatti, R., Rahatlou, S., Soffi, L., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Biino, C., Cartiglia, N., Casasso, S., Costa, M., Demaria, N., Mariotti, C., Maselli, S., Migliore, E., Monaco, V., Musich, M., Obertino, M. M., Ortona, G., Pastrone, N., Pelliccioni, M., Potenza, A., Romero, A., Ruspa, M., Sacchi, R., Solano, A., Staiano, A., Tamponi, U., Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., Della Ricca, G., Gobbo, B., La Licata, C., Marone, M., Montanino, D., Penzo, A., Schizzi, A., Zanetti, A., Kim, T. Y., Nam, S. K., Chang, S., Kim, D. H., Kim, G. N., Kim, J. E., Kong, D. J., Oh, Y. D., Park, H., Son, D. C., Kim, J. Y., Kim, Zero J., Song, S., Choi, S., Gyun, D., Hong, B., Jo, M., Kim, H., Kim, T. J., Lee, K. S., Park, S. K., Roh, Y., Choi, M., Kim, J. H., Park, C., Park, I. C., Park, S., Ryu, G., Choi, Y., Choi, Y. K., Goh, J., Kim, M. S., Kwon, E., Lee, B., Lee, J., Lee, S., Seo, H., Yu, I., Grigelionis, I., Juodagalvis, A., Castilla-Valdez, H., De La Cruz-Burelo, E., Heredia-de La Cruz, I., Lopez-Fernandez, R., Martínez-Ortega, J., Sanchez-Hernandez, A., Villasenor-Cendejas, L. M., Carrillo Moreno, S., Vazquez Valencia, F., Salazar Ibarguen, H. A., Casimiro Linares, E., Morelos Pineda, A., Reyes-Santos, M. A., Krofcheck, D., Bell, A. J., Butler, P. H., Doesburg, R., Reucroft, S., Silverwood, H., Ahmad, M., Asghar, M. I., Butt, J., Hoorani, H. R., Khalid, S., Khan, W. A., Khurshid, T., Qazi, S., Shah, M. A., Shoaib, M., Bialkowska, H., Boimska, B., Frueboes, T., Górski, M., Kazana, M., Nawrocki, K., Romanowska-Rybinska, K., Szleper, M., Wrochna, G., Zalewski, P., Brona, G., Bunkowski, K., Cwiok, M., Dominik, W., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Misiura, M., Wolszczak, W., Almeida, N., Bargassa, P., David, A., Faccioli, P., Ferreira Parracho, P. G., Gallinaro, M., Rodrigues Antunes, J., Seixas, J., Varela, J., Vischia, P., Bunin, P., Gavrilenko, M., Golutvin, I., Gorbunov, I., Kamenev, A., Karjavin, V., Konoplyanikov, V., Kozlov, G., Lanev, A., Malakhov, A., Matveev, V., Moisenz, P., Palichik, V., Perelygin, V., Shmatov, S., Skatchkov, N., Smirnov, V., Zarubin, A., Evstyukhin, S., Golovtsov, V., Ivanov, Y., Kim, V., Levchenko, P., Murzin, V., Oreshkin, V., Smirnov, I., Sulimov, V., Uvarov, L., Vavilov, S., Vorobyev, A., Vorobyev, An., Andreev, Yu., Dermenev, A., Gninenko, S., Golubev, N., Kirsanov, M., Krasnikov, N., Pashenkov, A., Tlisov, D., Toropin, A., Epshteyn, V., Erofeeva, M., Gavrilov, V., Lychkovskaya, N., Popov, V., Safronov, G., Semenov, S., Spiridonov, A., Stolin, V., Vlasov, E., Zhokin, A., Andreev, V., Azarkin, M., Dremin, I., Kirakosyan, M., Leonidov, A., Mesyats, G., Rusakov, S. V., Vinogradov, A., Belyaev, A., Boos, E., Bunichev, V., Dubinin, M., Dudko, L., Ershov, A., Gribushin, A., Klyukhin, V., Kodolova, O., Lokhtin, I., Markina, A., Obraztsov, S., Savrin, V., Snigirev, A., Azhgirey, I., Bayshev, I., Bitioukov, S., Kachanov, V., Kalinin, A., Konstantinov, D., Krychkine, V., Petrov, V., Ryutin, R., Sobol, A., Tourtchanovitch, L., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Adzic, P., Ekmedzic, M., Krpic, D., Milosevic, J., Aguilar-Benitez, M., Alcaraz Maestre, J., Battilana, C., Calvo, E., Cerrada, M., Chamizo Llatas, M., Colino, N., De La Cruz, B., Delgado Peris, A., Domínguez Vázquez, D., Fernandez Bedoya, C., Fernández Ramos, J. P., Ferrando, A., Flix, J., Fouz, M. C., Garcia-Abia, P., Gonzalez Lopez, O., Goy Lopez, S., Hernandez, J. M., Josa, M. I., Merino, G., Navarro De Martino, E., Puerta Pelayo, J., Quintario Olmeda, A., Redondo, I., Romero, L., Santaolalla, J., Soares, M. S., Willmott, C., Albajar, C., de Trocóniz, J. F., Brun, H., Cuevas, J., Fernandez Menendez, J., Folgueras, S., Gonzalez Caballero, I., Lloret Iglesias, L., Piedra Gomez, J., Brochero Cifuentes, J. A., Cabrillo, I. J., Calderon, A., Chuang, S. H., Duarte Campderros, J., Fernandez, M., Gomez, G., Gonzalez Sanchez, J., Graziano, A., Jorda, C., Lopez Virto, A., Marco, J., Marco, R., Martinez Rivero, C., Matorras, F., Munoz Sanchez, F. J., Rodrigo, T., Rodríguez-Marrero, A. Y., Ruiz-Jimeno, A., Scodellaro, L., Vila, I., Vilar Cortabitarte, R., Abbaneo, D., Auffray, E., Auzinger, G., Bachtis, M., Baillon, P., Ball, A. H., Barney, D., Bendavid, J., Benitez, J. F., Bernet, C., Bianchi, G., Bloch, P., Bocci, A., Bonato, A., Bondu, O., Botta, C., Breuker, H., Camporesi, T., Cerminara, G., Christiansen, T., Coarasa Perez, J. A., Colafranceschi, S., d’Enterria, D., Dabrowski, A., De Roeck, A., De Visscher, S., Di Guida, S., Dobson, M., Dupont-Sagorin, N., Elliott-Peisert, A., Eugster, J., Funk, W., Georgiou, G., Giffels, M., Gigi, D., Gill, K., Giordano, D., Girone, M., Giunta, M., Glege, F., Gomez-Reino Garrido, R., Gowdy, S., Guida, R., Hammer, J., Hansen, M., Harris, P., Hartl, C., Hinzmann, A., Innocente, V., Janot, P., Karavakis, E., Kousouris, K., Krajczar, K., Lecoq, P., Lee, Y.-J., Lourenço, C., Magini, N., Malberti, M., Malgeri, L., Mannelli, M., Masetti, L., Meijers, F., Mersi, S., Meschi, E., Moser, R., Mulders, M., Musella, P., Nesvold, E., Orsini, L., Palencia Cortezon, E., Perez, E., Perrozzi, L., Petrilli, A., Pfeiffer, A., Pierini, M., Pimiä, M., Piparo, D., Plagge, M., Polese, G., Quertenmont, L., Racz, A., Reece, W., Rolandi, G., Rovelli, C., Rovere, M., Sakulin, H., Santanastasio, F., Schäfer, C., Schwick, C., Segoni, I., Sekmen, S., Sharma, A., Siegrist, P., Silva, P., Simon, M., Sphicas, P., Spiga, D., Stoye, M., Tsirou, A., Veres, G. I., Vlimant, J. R., Wöhri, H. K., Worm, S. D., Zeuner, W. D., Bertl, W., Deiters, K., Erdmann, W., Gabathuler, K., Horisberger, R., Ingram, Q., Kaestli, H. C., König, S., Kotlinski, D., Langenegger, U., Renker, D., Rohe, T., Bachmair, F., Bäni, L., Bortignon, P., Buchmann, M. A., Casal, B., Chanon, N., Deisher, A., Dissertori, G., Dittmar, M., Donegà, M., Dünser, M., Eller, P., Freudenreich, K., Grab, C., Hits, D., Lecomte, P., Lustermann, W., Marini, A. C., Martinez Ruiz del Arbol, P., Mohr, N., Moortgat, F., Nägeli, C., Nef, P., Nessi-Tedaldi, F., Pandolfi, F., Pape, L., Pauss, F., Peruzzi, M., Ronga, F. J., Rossini, M., Sala, L., Sanchez, A. K., Starodumov, A., Stieger, B., Takahashi, M., Tauscher, L., Thea, A., Theofilatos, K., Treille, D., Urscheler, C., Wallny, R., Weber, H. A., Amsler, C., Chiochia, V., Favaro, C., Ivova Rikova, M., Kilminster, B., Millan Mejias, B., Otiougova, P., Robmann, P., Snoek, H., Taroni, S., Tupputi, S., Verzetti, M., Cardaci, M., Chen, K. H., Ferro, C., Kuo, C. M., Li, S. W., Lin, W., Lu, Y. J., Volpe, R., Yu, S. S., Bartalini, P., Chang, P., Chang, Y. H., Chang, Y. W., Chao, Y., Chen, K. F., Dietz, C., Grundler, U., Hou, W.-S., Hsiung, Y., Kao, K. Y., Lei, Y. J., Lu, R.-S., Majumder, D., Petrakou, E., Shi, X., Shiu, J. G., Tzeng, Y. M., Wang, M., Asavapibhop, B., Srimanobhas, N., Adiguzel, A., Bakirci, M. N., Cerci, S., Dozen, C., Dumanoglu, I., Eskut, E., Girgis, S., Gokbulut, G., Gurpinar, E., Hos, I., Kangal, E. E., Kayis Topaksu, A., Onengut, G., Ozdemir, K., Ozturk, S., Polatoz, A., Sogut, K., Sunar Cerci, D., Tali, B., Topakli, H., Vergili, M., Akin, I. V., Aliev, T., Bilin, B., Bilmis, S., Deniz, M., Gamsizkan, H., Guler, A. M., Karapinar, G., Ocalan, K., Ozpineci, A., Serin, M., Sever, R., Surat, U. E., Yalvac, M., Zeyrek, M., Gülmez, E., Isildak, B., Kaya, M., Kaya, O., Ozkorucuklu, S., Sonmez, N., Bahtiyar, H., Barlas, E., Cankocak, K., Günaydin, Y. O., Vardarli, F. 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T., Gaz, A., Luiggi Lopez, E., Nauenberg, U., Smith, J. G., Stenson, K., Ulmer, K. A., Wagner, S. R., Alexander, J., Chatterjee, A., Eggert, N., Gibbons, L. K., Hopkins, W., Khukhunaishvili, A., Kreis, B., Mirman, N., Nicolas Kaufman, G., Patterson, J. R., Ryd, A., Salvati, E., Sun, W., Teo, W. D., Thom, J., Thompson, J., Tucker, J., Weng, Y., Winstrom, L., Wittich, P., Winn, D., Abdullin, S., Albrow, M., Anderson, J., Apollinari, G., Bauerdick, L. A. T., Beretvas, A., Berryhill, J., Bhat, P. C., Burkett, K., Butler, J. N., Chetluru, V., Cheung, H. W. K., Chlebana, F., Cihangir, S., Elvira, V. D., Fisk, I., Freeman, J., Gao, Y., Gottschalk, E., Gray, L., Green, D., Gutsche, O., Hare, D., Harris, R. M., Hirschauer, J., Hooberman, B., Jindariani, S., Johnson, M., Joshi, U., Klima, B., Kunori, S., Kwan, S., Leonidopoulos, C., Linacre, J., Lincoln, D., Lipton, R., Lykken, J., Maeshima, K., Marraffino, J. M., Martinez Outschoorn, V. I., Maruyama, S., Mason, D., McBride, P., Mishra, K., Mrenna, S., Musienko, Y., Newman-Holmes, C., O’Dell, V., Prokofyev, O., Ratnikova, N., Sexton-Kennedy, E., Sharma, S., Spalding, W. J., Spiegel, L., Taylor, L., Tkaczyk, S., Tran, N. V., Uplegger, L., Vaandering, E. W., Vidal, R., Whitmore, J., Wu, W., Yang, F., Yun, J. C., Acosta, D., Avery, P., Bourilkov, D., Chen, M., Cheng, T., Das, S., De Gruttola, M., Di Giovanni, G. P., Dobur, D., Drozdetskiy, A., Field, R. D., Fisher, M., Fu, Y., Furic, I. K., Hugon, J., Kim, B., Konigsberg, J., Korytov, A., Kropivnitskaya, A., Kypreos, T., Low, J. F., Matchev, K., Milenovic, P., Mitselmakher, G., Muniz, L., Remington, R., Rinkevicius, A., Skhirtladze, N., Snowball, M., Yelton, J., Zakaria, M., Gaultney, V., Hewamanage, S., Lebolo, L. M., Linn, S., Markowitz, P., Martinez, G., Rodriguez, J. L., Adams, T., Askew, A., Bochenek, J., Chen, J., Diamond, B., Gleyzer, S. V., Haas, J., Hagopian, S., Hagopian, V., Johnson, K. F., Prosper, H., Veeraraghavan, V., Weinberg, M., Baarmand, M. M., Dorney, B., Hohlmann, M., Kalakhety, H., Yumiceva, F., Adams, M. R., Apanasevich, L., Bazterra, V. E., Betts, R. R., Bucinskaite, I., Callner, J., Cavanaugh, R., Evdokimov, O., Gauthier, L., Gerber, C. E., Hofman, D. J., Khalatyan, S., Kurt, P., Lacroix, F., Moon, D. H., O’Brien, C., Silkworth, C., Strom, D., Turner, P., Varelas, N., Akgun, U., Albayrak, E. A., Bilki, B., Clarida, W., Dilsiz, K., Duru, F., Griffiths, S., Merlo, J.-P., Mermerkaya, H., Mestvirishvili, A., Moeller, A., Nachtman, J., Newsom, C. R., Ogul, H., Onel, Y., Ozok, F., Sen, S., Tan, P., Tiras, E., Wetzel, J., Yetkin, T., Yi, K., Barnett, B. A., Blumenfeld, B., Bolognesi, S., Fehling, D., Giurgiu, G., Gritsan, A. V., Guo, Z. J., Hu, G., Maksimovic, P., Swartz, M., Whitbeck, A., Baringer, P., Bean, A., Benelli, G., Kenny, III, R. P., Murray, M., Noonan, D., Sanders, S., Stringer, R., Wood, J. S., Barfuss, A. F., Chakaberia, I., Ivanov, A., Khalil, S., Makouski, M., Maravin, Y., Shrestha, S., Svintradze, I., Gronberg, J., Lange, D., Rebassoo, F., Wright, D., Baden, A., Calvert, B., Eno, S. C., Gomez, J. A., Hadley, N. J., Kellogg, R. G., Kolberg, T., Lu, Y., Marionneau, M., Mignerey, A. C., Pedro, K., Peterman, A., Skuja, A., Temple, J., Tonjes, M. B., Tonwar, S. C., Apyan, A., Bauer, G., Busza, W., Butz, E., Cali, I. A., Chan, M., Dutta, V., Gomez Ceballos, G., Goncharov, M., Kim, Y., Klute, M., Lai, Y. S., Levin, A., Luckey, P. D., Ma, T., Nahn, S., Paus, C., Ralph, D., Roland, C., Roland, G., Stephans, G. S. F., Stöckli, F., Sumorok, K., Sung, K., Velicanu, D., Wolf, R., Wyslouch, B., Yang, M., Yilmaz, Y., Yoon, A. S., Zanetti, M., Zhukova, V., Dahmes, B., De Benedetti, A., Franzoni, G., Gude, A., Haupt, J., Kao, S. C., Klapoetke, K., Kubota, Y., Mans, J., Pastika, N., Rusack, R., Sasseville, M., Singovsky, A., Tambe, N., Turkewitz, J., Cremaldi, L. M., Kroeger, R., Perera, L., Rahmat, R., Sanders, D. A., Summers, D., Avdeeva, E., Bloom, K., Bose, S., Claes, D. R., Dominguez, A., Eads, M., Gonzalez Suarez, R., Keller, J., Kravchenko, I., Lazo-Flores, J., Malik, S., Meier, F., Snow, G. R., Dolen, J., Godshalk, A., Iashvili, I., Jain, S., Kharchilava, A., Kumar, A., Rappoccio, S., Wan, Z., Alverson, G., Barberis, E., Baumgartel, D., Chasco, M., Haley, J., Massironi, A., Nash, D., Orimoto, T., Trocino, D., Wood, D., Zhang, J., Anastassov, A., Hahn, K. A., Kubik, A., Lusito, L., Mucia, N., Odell, N., Pollack, B., Pozdnyakov, A., Schmitt, M., Stoynev, S., Velasco, M., Won, S., Berry, D., Brinkerhoff, A., Chan, K. M., Hildreth, M., Jessop, C., Karmgard, D. J., Kolb, J., Lannon, K., Luo, W., Lynch, S., Marinelli, N., Morse, D. M., Pearson, T., Planer, M., Ruchti, R., Slaunwhite, J., Valls, N., Wayne, M., Wolf, M., Antonelli, L., Bylsma, B., Durkin, L. S., Hill, C., Hughes, R., Kotov, K., Ling, T. Y., Puigh, D., Rodenburg, M., Smith, G., Vuosalo, C., Williams, G., Winer, B. L., Wolfe, H., Berry, E., Elmer, P., Halyo, V., Hebda, P., Hegeman, J., Hunt, A., Jindal, P., Koay, S. A., Lopes Pegna, D., Lujan, P., Marlow, D., Medvedeva, T., Mooney, M., Olsen, J., Piroué, P., Quan, X., Raval, A., Saka, H., Stickland, D., Tully, C., Werner, J. S., Zenz, S. C., Zuranski, A., Brownson, E., Lopez, A., Mendez, H., Ramirez Vargas, J. E., Alagoz, E., Benedetti, D., Bolla, G., Bortoletto, D., De Mattia, M., Everett, A., Hu, Z., Jones, M., Jung, K., Koybasi, O., Kress, M., Leonardo, N., Maroussov, V., Merkel, P., Miller, D. H., Neumeister, N., Shipsey, I., Silvers, D., Svyatkovskiy, A., Vidal Marono, M., Wang, F., Xu, L., Yoo, H. D., Zablocki, J., Zheng, Y., Guragain, S., Parashar, N., Adair, A., Akgun, B., Ecklund, K. M., Geurts, F. J. M., Li, W., Padley, B. P., Redjimi, R., Roberts, J., Zabel, J., Betchart, B., Bodek, A., Covarelli, R., de Barbaro, P., Demina, R., Eshaq, Y., Ferbel, T., Garcia-Bellido, A., Goldenzweig, P., Han, J., Harel, A., Miner, D. C., Petrillo, G., Vishnevskiy, D., Zielinski, M., Bhatti, A., Ciesielski, R., Demortier, L., Goulianos, K., Lungu, G., Malik, S., Mesropian, C., Arora, S., Barker, A., Chou, J. P., Contreras-Campana, C., Contreras-Campana, E., Duggan, D., Ferencek, D., Gershtein, Y., Gray, R., Halkiadakis, E., Hidas, D., Lath, A., Panwalkar, S., Park, M., Patel, R., Rekovic, V., Robles, J., Rose, K., Salur, S., Schnetzer, S., Seitz, C., Somalwar, S., Stone, R., Thomas, S., Walker, M., Cerizza, G., Hollingsworth, M., Spanier, S., Yang, Z. C., York, A., Eusebi, R., Flanagan, W., Gilmore, J., Kamon, T., Khotilovich, V., Montalvo, R., Osipenkov, I., Pakhotin, Y., Perloff, A., Roe, J., Safonov, A., Sakuma, T., Suarez, I., Tatarinov, A., Toback, D., Akchurin, N., Damgov, J., Dragoiu, C., Dudero, P. R., Jeong, C., Kovitanggoon, K., Lee, S. W., Libeiro, T., Volobouev, I., Appelt, E., Delannoy, A. G., Greene, S., Gurrola, A., Johns, W., Maguire, C., Mao, Y., Melo, A., Sharma, M., Sheldon, P., Snook, B., Tuo, S., Velkovska, J., Arenton, M. W., Boutle, S., Cox, B., Francis, B., Goodell, J., Hirosky, R., Ledovskoy, A., Lin, C., Neu, C., Wood, J., Gollapinni, S., Harr, R., Karchin, P. E., Kottachchi Kankanamge Don, C., Lamichhane, P., Sakharov, A., Anderson, M., Belknap, D. A., Borrello, L., Carlsmith, D., Cepeda, M., Dasu, S., Friis, E., Grogg, K. S., Grothe, M., Hall-Wilton, R., Herndon, M., Hervé, A., Kaadze, K., Klabbers, P., Klukas, J., Lanaro, A., Lazaridis, C., Loveless, R., Mohapatra, A., Mozer, M. U., Ojalvo, I., Pierro, G. A., Ross, I., Savin, A., Smith, W. H., and Swanson, J.

Published
2022
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44. Ground Truth Validation of Sentinel-2 Data Using Mobile Wireless Ad Hoc Sensor Networks (MWSN) in Vegetation Stands

Author

Hannes Mollenhauer, Erik Borg, Bringfried Pflug, Bernd Fichtelmann, Thorsten Dahms, Sebastian Lorenz, Olaf Mollenhauer, Angela Lausch, Jan Bumberger, and Peter Dietrich

Subjects
autonomous wireless ad hoc sensor network, Earth observation, Sentinel-2, ground truth data, DEMMIN, close-range measurement, Science
Abstract

Satellite-based remote sensing (RS) data are increasingly used to map and monitor local, regional, and global environmental phenomena and processes. Although the availability of RS data has improved significantly, especially in recent years, operational applications to derive value-added information products are still limited by close-range validation and verification deficits. This is mainly due to the gap between standardized and sufficiently available close-range and RS data in type, quality, and quantity. However, to ensure the best possible linkage of close-range and RS data, it makes sense to simultaneously record close-range data in addition to the availability of environmental models. This critical gap is filled by the presented mobile wireless ad hoc sensor network (MWSN) concept, which records sufficient close-range data automatically and in a standardized way, even at local and regional levels. This paper presents a field study conducted as part of the Durable Environmental Multidisciplinary Monitoring Information Network (DEMMIN), focusing on the information gained with respect to estimating the vegetation state with the help of multispectral data by simultaneous observation of an MWSN during a Sentinel-2A (S2A) overflight. Based on a cross-calibration of the two systems, a comparable spectral characteristic of the data sets could be achieved. Building upon this, an analysis of the data regarding the influence of solar altitude, test side topography and land cover, and sub-pixel heterogeneity was accomplished. In particular, variations due to spatial heterogeneity and dynamics in the diurnal cycle show to what extent such complementary measurement systems can improve the data from RS products concerning the vegetation type and atmospheric conditions.

Published
2023
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45. Integrating random forest and crop modeling improves the crop yield prediction of winter wheat and oil seed rape

Author

Maninder Singh Dhillon, Thorsten Dahms, Carina Kuebert-Flock, Thomas Rummler, Joel Arnault, Ingolf Steffan-Dewenter, and Tobias Ullmann

Subjects
crop modeling, random forest, machine learning, NDVI, satellite, landsat, Geophysics. Cosmic physics, QC801-809, Meteorology. Climatology, QC851-999
Abstract

The fast and accurate yield estimates with the increasing availability and variety of global satellite products and the rapid development of new algorithms remain a goal for precision agriculture and food security. However, the consistency and reliability of suitable methodologies that provide accurate crop yield outcomes still need to be explored. The study investigates the coupling of crop modeling and machine learning (ML) to improve the yield prediction of winter wheat (WW) and oil seed rape (OSR) and provides examples for the Free State of Bavaria (70,550 km2), Germany, in 2019. The main objectives are to find whether a coupling approach [Light Use Efficiency (LUE) + Random Forest (RF)] would result in better and more accurate yield predictions compared to results provided with other models not using the LUE. Four different RF models [RF1 (input: Normalized Difference Vegetation Index (NDVI)), RF2 (input: climate variables), RF3 (input: NDVI + climate variables), RF4 (input: LUE generated biomass + climate variables)], and one semi-empiric LUE model were designed with different input requirements to find the best predictors of crop monitoring. The results indicate that the individual use of the NDVI (in RF1) and the climate variables (in RF2) could not be the most accurate, reliable, and precise solution for crop monitoring; however, their combined use (in RF3) resulted in higher accuracies. Notably, the study suggested the coupling of the LUE model variables to the RF4 model can reduce the relative root mean square error (RRMSE) from −8% (WW) and −1.6% (OSR) and increase the R2 by 14.3% (for both WW and OSR), compared to results just relying on LUE. Moreover, the research compares models yield outputs by inputting three different spatial inputs: Sentinel-2(S)-MOD13Q1 (10 m), Landsat (L)-MOD13Q1 (30 m), and MOD13Q1 (MODIS) (250 m). The S-MOD13Q1 data has relatively improved the performance of models with higher mean R2 [0.80 (WW), 0.69 (OSR)], and lower RRMSE (%) (9.18, 10.21) compared to L-MOD13Q1 (30 m) and MOD13Q1 (250 m). Satellite-based crop biomass, solar radiation, and temperature are found to be the most influential variables in the yield prediction of both crops.

Published
2023
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46. Candida albicans Reactive Oxygen Species (ROS)-Dependent Lethality and ROS-Independent Hyphal and Biofilm Inhibition by Eugenol and Citral

Author

Zinnat Shahina, Easter Ndlovu, Omkaar Persaud, Taranum Sultana, and Tanya E. S. Dahms

Subjects
Candida albicans, essential oils, cell death, virulence inhibition, citral, eugenol, Microbiology, QR1-502
Abstract

ABSTRACT Candida albicans is part of the normal human flora but is most frequently isolated as the causative opportunistic pathogen of candidiasis. Plant-based essential oils and their components have been extensively studied as antimicrobials, but their antimicrobial impacts are poorly understood. Phenylpropenoids and monoterpenes, for example, eugenol from clove and citral from lemon grass, are potent antifungals against a wide range of pathogens. We report the cellular response of C. albicans to eugenol and citral, alone and combined, using biochemical and microscopic assays. The MICs of eugenol and citral were 1,000 and 256 μg/mL, respectively, with the two exhibiting additive effects based on a fractional inhibitory concentration index of 0.83 ± 0.14. High concentrations of eugenol caused membrane damage, oxidative stress, vacuole segregation, microtubule dysfunction and cell cycle arrest at the G1/S phase, and while citral had similar impacts, they were reactive oxygen species (ROS) independent. At sublethal concentrations (1/2 to 1/4 MIC), both oils disrupted microtubules and hyphal and biofilm formation in an ROS-independent manner. While both compounds disrupt the cell membrane, eugenol had a greater impact on membrane dysfunction. This study shows that eugenol and citral can induce vacuole and microtubule dysfunction, along with the inhibition of hyphal and biofilm formation. IMPORTANCE Candida albicans is a normal resident on and in the human body that can cause relatively benign infections. However, when our immune system is severely compromised (e.g., cancer chemotherapy patients) or underdeveloped (e.g., newborns), this fungus can become a deadly pathogen, infecting the bloodstream and organs. Since there are only a few effective antifungal agents that can be used to combat fungal infections, these fungi have been exposed to them over and over again, allowing the fungi to develop resistance. Instead of developing antifungal agents that kill the fungi, some of which have undesirable side effects on the human host, researchers have proposed to target the fungal traits that make the fungus more virulent. Here, we show how two components of plant-based essential oils, eugenol and citral, are effective inhibitors of C. albicans virulence traits.

Published
2022
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48. Efficacy and side effects of bio-fabricated sardine fish scale silver nanoparticles against malarial vector Anopheles stephensi

Author

Kadarkarai Murugan, Jayapal Subramaniam, Rajapandian Rajaganesh, Chellasamy Panneerselvam, Pandiyan Amuthavalli, Murugan Vasanthakumaran, Sudalaimani Jayashanthini, Devakumar Dinesh, Jaganathan Anitha, Lan Wang, Jiang-Shiou Hwang, Hans-Uwe Dahms, Sunaina Mudigonda, and Al Thabiani Aziz

Subjects
Medicine, Science
Abstract

Abstract Mosquitoes are a great menace for humankind since they transmit pathogenic organisms causing Malaria, Dengue, Chikungunya, Elephantiasis and Japanese encephalitis. There is an urgent need to discover new and novel biological tools to mitigate mosquito-borne diseases. To develop bioinsecticides through newly developed nanotechnology is another option in the present research scenario. In this study we synthesize and characterize sardine fish scales with silver nitrate by adopting various instrumental techniques such as UV- and FTIR-spectroscopy, energy-dispersive X-ray (EDAX), X-ray diffraction analyses (XRD) and scanning electron microscopy (SEM). Toxicity bioassays were conducted with young developmental stages of mosquito vectors. Significant mortality appeared after different life stages of mosquito vectors (young larval and pupal instars were exposed to the nanomaterials). LC50 values were 13.261 ppm for young first instar larvae and 32.182 ppm for pupae. Feeding and predatory potential of G. affinis, before and after exposure to nanoparticles against mosquito larval (I & II) instars of the mosquitoes showed promising results in laboratory experiments. Feeding potential of mosquito fish without nanoparticle treatment was 79.7% and 70.55% for the first and second instar larval populations respectively. At the nanoparticle-exposed situation the predatory efficiency of mosquitofish was 94.15% and 84.3%, respectively. Antioxidant enzymes like (SOD), (CAT), and (LPO) were estimated in the gill region of sardine fish in control and experimental waters. A significant reduction of egg hatchability was evident after nanoparticle application. It became evident from this study that the nano-fabricated materials provide suitable tools to control the malaria vector Anopheles stephensi in the aquatic phase of its life cycle. This finding suggests an effective novel approach to mosquito control.

Published
2021
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50. Pseudorapidity distributions of charged particles as a function of mid- and forward rapidity multiplicities in pp collisions at $$\sqrt{s}$$ s = 5.02, 7 and 13 TeV

Author

ALICE Collaboration, S. Acharya, D. Adamová, A. Adler, J. Adolfsson, M. M. Aggarwal, S. Agha, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S. U. Ahn, Z. Akbar, A. Akindinov, M. Al-Turany, S. N. Alam, D. S. D. Albuquerque, D. Aleksandrov, B. Alessandro, H. M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M. N. Anaam, C. Andrei, D. Andreou, A. Andronic, M. Angeletti, V. Anguelov, T. Antičić, F. Antinori, P. Antonioli, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, M. Arratia, I. C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M. D. Azmi, A. Badalà, Y. W. Baek, X. Bai, R. Bailhache, R. Bala, A. Balbino, A. Baldisseri, M. Ball, D. Banerjee, R. Barbera, L. Barioglio, M. Barlou, G. G. Barnaföldi, L. S. Barnby, V. Barret, P. Bartalini, C. Bartels, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J. L. Bazo Alba, I. G. Bearden, C. Beattie, I. Belikov, A. D. C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, A. Berdnikova, D. Berenyi, D. Berzano, M. G. Besoiu, L. Betev, A. Bhasin, I. R. Bhat, M. A. Bhat, B. Bhattacharjee, A. Bianchi, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, A. Bilandzic, G. Biro, S. Biswas, J. T. Blair, D. Blau, M. B. Blidaru, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G. E. Bruno, M. D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, P. Buncic, Z. Buthelezi, J. B. Butt, S. A. Bysiak, D. Caffarri, M. Cai, A. Caliva, E. Calvo Villar, J. M. M. Camacho, R. S. Camacho, P. Camerini, A. A. Capon, F. Carnesecchi, R. Caron, J. Castillo Castellanos, A. J. Castro, E. A. R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, W. Chang, S. Chapeland, M. Chartier, S. Chattopadhyay, A. Chauvin, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D. D. Chinellato, S. Cho, P. Chochula, P. Christakoglou, C. H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, M. R. Ciupek, G. Clai, J. Cleymans, F. Colamaria, J. S. Colburn, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J. G. Contreras, T. M. Cormier, Y. Corrales Morales, P. Cortese, M. R. Cosentino, F. Costa, S. Costanza, P. Crochet, E. Cuautle, P. Cui, L. Cunqueiro, T. Dahms, A. Dainese, F. P. A. Damas, M. C. Danisch, A. Danu, D. Das, I. Das, P. Das, S. Das, A. Dash, S. Dash, S. De, A. De Caro, G. de Cataldo, L. De Cilladi, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, S. Deb, H. F. Degenhardt, K. R. Deja, A. Deloff, S. Delsanto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, R. A. Diaz, T. Dietel, P. Dillenseger, Y. Ding, R. Divià, D. U. Dixit, Ø. Djuvsland, U. Dmitrieva, A. Dobrin, B. Dönigus, O. Dordic, A. K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, T. M. Eder, R. J. Ehlers, V. N. Eikeland, D. Elia, B. Erazmus, F. Erhardt, A. Erokhin, M. R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, A. Festanti, V. J. G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F. M. Fionda, G. Fiorenza, F. Flor, A. N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, U. Frankenfeld, U. Fuchs, C. Furget, A. Furs, M. Fusco Girard, J. J. Gaardhøje, M. Gagliardi, A. M. Gago, A. Gal, C. D. Galvan, P. Ganoti, C. Garabatos, J. R. A. Garcia, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E. F. Gauger, M. B. Gay Ducati, M. Germain, J. Ghosh, P. Ghosh, S. K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, A. M. C. Glaenzer, P. Glässel, V. Gonzalez, L. H. González-Trueba, S. Gorbunov, L. Görlich, A. Goswami, S. Gotovac, V. Grabski, L. K. Graczykowski, K. L. Graham, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, A. Grigoryan, S. Grigoryan, O. S. Groettvik, F. Grosa, J. F. Grosse-Oetringhaus, R. Grosso, R. Guernane, M. Guittiere, K. Gulbrandsen, T. Gunji, A. Gupta, R. Gupta, I. B. Guzman, R. Haake, M. K. Habib, C. Hadjidakis, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M. R. Haque, A. Harlenderova, J. W. Harris, A. Harton, J. A. Hasenbichler, H. Hassan, Q. U. Hassan, D. Hatzifotiadou, P. Hauer, L. B. Havener, S. Hayashi, S. T. Heckel, E. Hellbär, H. Helstrup, A. Herghelegiu, T. Herman, E. G. Hernandez, G. Herrera Corral, F. Herrmann, K. F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hohlweger, J. Honermann, G. H. Hong, D. Horak, A. Hornung, S. Hornung, R. Hosokawa, P. Hristov, C. Huang, C. Hughes, P. Huhn, T. J. Humanic, H. Hushnud, L. A. Husova, N. Hussain, S. A. Hussain, D. Hutter, J. P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G. M. Innocenti, M. Ippolitov, A. Isakov, M. S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, B. Jacak, N. Jacazio, P. M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M. J. Jakubowska, M. A. Janik, T. Janson, M. Jercic, O. Jevons, M. Jin, F. Jonas, P. G. Jones, J. Jung, M. Jung, A. Jusko, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, A. Kazantsev, U. Kebschull, R. Keidel, M. Keil, B. Ketzer, Z. Khabanova, A. M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, D. Kim, D. J. Kim, E. J. Kim, J. Kim, J. S. Kim, M. Kim, S. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J. L. Klay, C. Klein, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, M. L. Knichel, A. G. Knospe, C. Kobdaj, M. K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S. A. Konigstorfer, P. J. Konopka, G. Kornakov, L. Koska, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, E. Kryshen, M. Krzewicki, V. Kučera, C. Kuhn, P. G. Kuijer, L. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A. B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M. J. Kweon, J. Y. Kwon, Y. Kwon, S. L. La Pointe, P. La Rocca, Y. S. Lai, A. Lakrathok, M. Lamanna, R. Langoy, K. Lapidus, A. Lardeux, P. Larionov, E. Laudi, R. Lavicka, T. Lazareva, R. Lea, J. Lee, S. Lee, J. Lehrbach, R. C. Lemmon, I. León Monzón, E. D. Lesser, M. Lettrich, P. Lévai, X. Li, X. L. Li, J. Lien, R. Lietava, B. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, A. Liu, J. Liu, W. J. Llope, I. M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J. A. Lopez, X. Lopez, E. López Torres, J. R. Luhder, M. Lunardon, G. Luparello, Y. G. Ma, A. Maevskaya, M. Mager, S. M. Mahmood, T. Mahmoud, A. Maire, R. D. Majka, M. Malaev, Q. W. Malik, L. Malinina, D. Mal’Kevich, N. Mallick, P. Malzacher, G. Mandaglio, V. Manko, F. Manso, V. Manzari, Y. Mao, M. Marchisone, J. Mareš, G. V. Margagliotti, A. Margotti, A. Marín, C. Markert, M. Marquard, N. A. Martin, P. Martinengo, J. L. Martinez, M. I. Martínez, G. Martínez García, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, A. Mastroserio, A. M. Mathis, O. Matonoha, P. F. T. Matuoka, A. Matyja, C. Mayer, F. Mazzaschi, M. Mazzilli, M. A. Mazzoni, A. F. Mechler, F. Meddi, Y. Melikyan, A. Menchaca-Rocha, E. Meninno, A. S. Menon, M. Meres, S. Mhlanga, Y. Miake, L. Micheletti, L. C. Migliorin, D. L. Mihaylov, K. Mikhaylov, A. N. Mishra, D. Miśkowiec, A. Modak, N. Mohammadi, A. P. Mohanty, B. Mohanty, M. Mohisin Khan, Z. Moravcova, C. Mordasini, D. A. Moreira De Godoy, L. A. P. Moreno, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, E. Mudnic, D. Mühlheim, S. Muhuri, J. D. Mulligan, A. Mulliri, M. G. Munhoz, R. H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, C. J. Myers, J. W. Myrcha, B. Naik, R. Nair, B. K. Nandi, R. Nania, E. Nappi, M. U. Naru, A. F. Nassirpour, C. Nattrass, R. Nayak, T. K. Nayak, S. Nazarenko, A. Neagu, R. A. Negrao De Oliveira, L. Nellen, S. V. Nesbo, G. Neskovic, D. Nesterov, B. S. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, M. Ogino, A. Ohlson, J. Oleniacz, A. C. Oliveira Da Silva, M. H. Oliver, C. Oppedisano, A. Ortiz Velasquez, T. Osako, A. Oskarsson, J. Otwinowski, K. Oyama, Y. Pachmayer, V. Pacik, S. Padhan, D. Pagano, G. Paić, P. Palni, J. Pan, S. Panebianco, P. Pareek, J. Park, J. E. Parkkila, S. Parmar, S. P. Pathak, B. Paul, J. Pazzini, H. Pei, T. Peitzmann, X. Peng, L. G. Pereira, H. Pereira Da Costa, D. Peresunko, G. M. Perez, S. Perrin, Y. Pestov, V. Petráček, M. Petrovici, R. P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, D. Pistone, M. Płoskoń, M. Planinic, F. Pliquett, M. G. Poghosyan, B. Polichtchouk, N. Poljak, A. Pop, S. Porteboeuf-Houssais, V. Pozdniakov, S. K. Prasad, R. Preghenella, F. Prino, C. A. Pruneau, I. Pshenichnov, M. Puccio, J. Putschke, S. Qiu, L. Quaglia, R. E. Quishpe, S. Ragoni, S. Raha, J. Rak, A. Rakotozafindrabe, L. Ramello, F. Rami, S. A. R. Ramirez, R. Raniwala, S. Raniwala, S. S. Räsänen, R. Rath, I. Ravasenga, K. F. Read, A. R. Redelbach, K. Redlich, A. Rehman, P. Reichelt, F. Reidt, R. Renfordt, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, T. Richert, M. Richter, P. Riedler, W. Riegler, F. Riggi, C. Ristea, S. P. Rode, M. Rodríguez Cahuantzi, K. Røed, R. Rogalev, E. Rogochaya, D. Rohr, D. Röhrich, P. F. Rojas, P. S. Rokita, F. Ronchetti, A. Rosano, E. D. Rosas, K. Roslon, A. Rossi, A. Rotondi, A. Roy, P. Roy, O. V. Rueda, R. Rui, B. Rumyantsev, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, O. A. M. Saarimaki, R. Sadek, S. Sadhu, S. Sadovsky, J. Saetre, K. Šafařík, S. K. Saha, S. Saha, B. Sahoo, P. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P. K. Sahu, J. Saini, S. Sakai, S. Sambyal, V. Samsonov, D. Sarkar, N. Sarkar, P. Sarma, V. M. Sarti, M. H. P. Sas, E. Scapparone, J. Schambach, H. S. Scheid, C. Schiaua, R. Schicker, A. Schmah, C. Schmidt, H. R. Schmidt, M. O. Schmidt, M. Schmidt, N. V. Schmidt, A. R. Schmier, J. Schukraft, Y. Schutz, K. Schwarz, K. Schweda, G. Scioli, E. Scomparin, J. E. Seger, Y. Sekiguchi, D. Sekihata, I. Selyuzhenkov, S. Senyukov, J. J. Seo, D. Serebryakov, L. Šerkšnytė, A. Sevcenco, A. Shabanov, A. Shabetai, R. Shahoyan, W. Shaikh, A. Shangaraev, A. Sharma, H. Sharma, M. Sharma, N. Sharma, S. Sharma, O. Sheibani, A. I. Sheikh, K. Shigaki, M. Shimomura, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, D. Silvermyr, G. Simatovic, G. Simonetti, B. Singh, R. Singh, V. K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T. B. Skaali, M. Slupecki, N. Smirnov, R. J. M. Snellings, T. W. Snellman, C. Soncco, J. Song, A. Songmoolnak, F. Soramel, S. Sorensen, I. Sputowska, J. Stachel, I. Stan, P. J. Steffanic, S. F. Stiefelmaier, D. Stocco, M. M. Storetvedt, L. D. Stritto, C. P. Stylianidis, A. A. P. Suaide, T. Sugitate, C. Suire, M. Suleymanov, M. Suljic, R. Sultanov, M. Šumbera, V. Sumberia, S. Sumowidagdo, S. Swain, A. Szabo, I. Szarka, U. Tabassam, S. F. Taghavi, G. Taillepied, J. Takahashi, G. J. Tambave, S. Tang, M. Tarhini, M. G. Tarzila, A. Tauro, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, S. Thakur, D. Thomas, F. Thoresen, R. Tieulent, A. Tikhonov, A. R. Timmins, M. Tkacik, A. Toia, N. Topilskaya, M. Toppi, F. Torales-Acosta, S. R. Torres, A. Trifiró, S. Tripathy, T. Tripathy, S. Trogolo, G. Trombetta, L. Tropp, V. Trubnikov, W. H. Trzaska, T. P. Trzcinski, B. A. Trzeciak, A. Tumkin, R. Turrisi, T. S. Tveter, K. Ullaland, E. N. Umaka, A. Uras, G. L. Usai, M. Vala, N. Valle, S. Vallero, N. van der Kolk, L. V. R. van Doremalen, M. van Leeuwen, P. Vande Vyvre, D. Varga, Z. Varga, M. Varga-Kofarago, A. Vargas, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, V. Vechernin, E. Vercellin, S. Vergara Limón, L. Vermunt, R. Vernet, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, G. Vino, A. Vinogradov, T. Virgili, V. Vislavicius, A. Vodopyanov, B. Volkel, M. A. Völkl, K. Voloshin, S. A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, D. Voscek, J. Vrláková, B. Wagner, M. Weber, S. G. Weber, A. Wegrzynek, S. C. Wenzel, J. P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G. A. Willems, E. Willsher, B. Windelband, M. Winn, W. E. Witt, J. R. Wright, Y. Wu, R. Xu, S. Yalcin, Y. Yamaguchi, K. Yamakawa, S. Yang, S. Yano, Z. Yin, H. Yokoyama, I.-K. Yoo, J. H. Yoon, S. Yuan, A. Yuncu, V. Yurchenko, V. Zaccolo, A. Zaman, C. Zampolli, H. J. C. Zanoli, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, H. Zbroszczyk, M. Zhalov, S. Zhang, X. Zhang, Z. Zhang, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, A. Zichichi, G. Zinovjev, and N. Zurlo

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The multiplicity dependence of the pseudorapidity density of charged particles in proton–proton (pp) collisions at centre-of-mass energies $$\sqrt{s}~=~5.02$$ s = 5.02 , 7 and 13 TeV measured by ALICE is reported. The analysis relies on track segments measured in the midrapidity range ( $$|\eta | < 1.5$$ | η | < 1.5 ). Results are presented for inelastic events having at least one charged particle produced in the pseudorapidity interval $$|\eta |

Published
2021
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