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41,337 results on '"DRUG development"'

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1. Sequence-dependent model of allosteric communication.

2. Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies.

3. Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization.

4. Testing dilemmas in the clinic: Lessons learned from biomarker-based drug development.

5. Biomarker-Driven Oncology Trial Design and Subgroup Characterization: Challenges and Potential Solutions.

6. The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease.

7. Rapid Self‐Assembly Mini‐Livers Protect Mice Against Severe Hepatectomy‐Induced Liver Failure.

8. Defining the next generation of severe malaria treatment: a target product profile.

9. Adaptive designs were primarily used but inadequately reported in early phase drug trials.

10. GCARDTI: Drug–target interaction prediction based on a hybrid mechanism in drug SELFIES.

11. Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.

12. Methods for Neuroscience Drug Development: Guidance on Standardization of the Process for Defining Clinical Outcome Strategies in Clinical Trials.

13. Defeating MYC with drug combinations or dual-targeting drugs.

15. Treatment of atopic dermatitis: Recently approved drugs and advanced clinical development programs.

16. Protein tyrosine phosphatase 1B in metabolic diseases and drug development.

17. Electrolytic bubble-based flow sensing using electrochemical resistance measurement in a microchannel.

18. Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry.

19. Food‐Drug Effects and Pediatric Drug Development Studies Submitted to the US Food and Drug Administration, 2012‐2022.

20. Procyanidin C1 inhibits tumor growth and metastasis in colon cancer via modulating miR-501-3p/HIGD1A axis.

21. A deep learning based multi-model approach for predicting drug-like chemical compound's toxicity.

22. DTKGIN: Predicting drug-target interactions based on knowledge graph and intent graph.

24. TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.

25. Aldosterone synthase inhibitor (BI 690517) therapy for people with diabetes and albuminuric chronic kidney disease: A multicentre, randomized, double‐blind, placebo‐controlled, Phase I trial.

26. Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review.

27. Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum.

28. Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.

29. Targeting decaprenylphosphoryl-β-D-ribose 2′-epimerase for Innovative Drug Development Against Mycobacterium Tuberculosis Drug-Resistant Strains.

30. The impact of the exodus of big pharmaceutical companies from Nigeria on antimicrobial resistance in the West African subregion.

31. Homeostasis imbalance process ontology: a study on COVID-19 infectious processes.

32. Silver‐Enabled Cycloaddition of Bicyclobutanes with Isocyanides for the Synthesis of Polysubstituted 3‐Azabicyclo[3.1.1]heptanes.

33. New-generation advanced PROTACs as potential therapeutic agents in cancer therapy.

34. Silver‐Enabled Cycloaddition of Bicyclobutanes with Isocyanides for the Synthesis of Polysubstituted 3‐Azabicyclo[3.1.1]heptanes.

35. An innovative method to strengthen evidence for potential drug safety signals using Electronic Health Records.

36. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder.

37. Stimulating STING for cancer therapy: Taking the extracellular route.

38. Synthesis and Functionalization of Azetidine‐Containing Small Macrocyclic Peptides.

39. Recent and anticipated novel drug approvals for 2024.

40. Early Stage In Vitro Bioprofiling of Potential Low-Molecular-Weight Organoboron Compounds for Boron Neutron Capture Therapy (BNCT)—Proposal for a Guide.

41. Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors.

42. DDCM: A Computational Strategy for Drug Repositioning Based on Support-Vector Regression Algorithm.

43. Prediction of Drug-Target Affinity Using Attention Neural Network.

44. Novel 9-Methylanthracene Derivatives as p53 Activators for the Treatment of Glioblastoma Multiforme.

45. Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16.

46. Thinking Outside the Box: Indirect Myc Modulation in Canine B-Cell Lymphoma.

47. Historical Perspective and Current Trends in Anticancer Drug Development.

48. Biomarkers as Endpoints in Clinical Trials for Alzheimer's Disease.

49. Review article: New developments in biomarkers and clinical drug development in alpha‐1 antitrypsin deficiency‐related liver disease.

50. Phytochemical evaluation of Ziziphus mucronata and Xysmalobium undulutum towards the discovery and development of anti-malarial drugs.

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