24,547 results on '"DATABASE searching"'
Search Results
2. Using Qualtrics XM to Create a Point-of-Use Survey to Assess the Usability of a Local Implementation of Primo.
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Black, Matthew, Ganshorn, Heather, and Wheeler, Justine
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REMOTE access networks , *ACADEMIC libraries , *LIBRARY reference services , *DATABASE searching , *APPLICATION software , *MOBILE apps , *SURVEYS , *LIBRARY public services , *INFORMATION retrieval , *WORLD Wide Web , *INFORMATION technology - Abstract
In 2020, Libraries and Cultural Resources (LCR) at the University of Calgary used Qualtrics XM to design and pilot a point-of-use survey to collect user feedback on the usability of our implementation of Primo, Ex Libris's web-scale discovery service. Over a two-week period, users were presented with the pop-up survey while searching and asked to provide feedback. This article summarizes how we designed and implemented this point-of-use survey and the lessons learned from this project. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Influence of 3D-Printing Parameters and Characteristics of Complete Denture Bases on Evaluated Properties: A Scoping Review.
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Vilela Teixeira, Ana Beatriz and Cândido dos Reis, Andréa
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COMPLETE dentures ,MICROBIAL adhesion ,SCIENCE databases ,DATABASE searching ,ANTI-infective agents - Abstract
Purpose: To verify the parameters and characteristics evaluated in 3D-printed complete denture (CD) bases and how they influence CD properties. Materials and Methods: This work was registered in Open Science Framework (osf.io/4um6v) and followed the PRISMA Extension for Scoping Reviews. A search of peer-reviewed articles published up to April 9, 2020, was performed on the PubMed, LILACS, Cochrane Library, and Science Direct databases. The review question based on the PCC (population, concept, and context) was: What printing parameters and characteristics of CD bases can influence their properties? Results: The database search resulted in 1,945 articles, and the initial screening was carried out in 1,390 articles, 17 of which were selected for inclusion in this review. The present authors verified that cleaning the prosthesis with alcohol after printing followed by a postcuring cycle influences biocompatibility and residual monomers. The printing angle influences physicomechanical properties, microbial adhesion, and tissue adaptation. Accuracy is influenced by layer thickness and manufacturing technique, which also influences retention and tissue adaptation. The incorporation of antimicrobial agents influences physicomechanical properties and antimicrobial activity. The method of union between the denture base and teeth influences mechanical strength. Conclusions: Printed denture bases showed good adaptation to tissues and accuracy with 100-µm layer thickness, but the base must be cleaned in ethanol followed by postcuring for better biocompatibility. Nano- and microparticles can be added to provide antimicrobial activity and better resistance. The printing angle and mechanical properties must be better evaluated. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Reporting quality of scoping reviews in endodontics: A meta‐research study.
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Tzanetakis, Giorgos N., Petridis, Xenos, Jakovljevic, Aleksandar, Koletsi, Despina, Nagendrababu, Venkateshbabu, Duncan, Henry F., and Dummer, Paul M. H.
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QUANTILE regression , *SCIENCE databases , *WEB databases , *DESCRIPTIVE statistics , *DATABASE searching - Abstract
Objectives Methods Results Conclusions To evaluate the reporting quality of Scoping Reviews (ScRs) in endodontics according to the PRISMA Extension Checklist for Scoping Reviews (PRISMA‐ScR) and to analyse their association with a range of publication and methodological/reporting characteristics.Pubmed, Scopus, and Web of Science databases were searched up to 31 January 2024 to identify scoping reviews in the field of endodontics. An additional search was performed in three leading endodontic journals. Study selection and appraising the quality of the studies was carried out independently by two reviewers. Each of the 20 PRISMA‐ScR items were allocated a score of either 0, 0.5 or 1 to reflect the completeness of the reporting. An item‐specific and overall percentage reporting quality score was calculated and reported through descriptive statistics across a range of publication, as well as methodological/reporting characteristics. A univariable and multivariable quantile regression was performed to identify the effect of publication and methodological/reporting characteristics (year of publication, journal, inclusion of an appropriate reporting guideline, and study registration) on the overall percentage reporting quality score. Association of reporting quality score with publication characteristics was then investigated.A total of 40 ScRs were identified and included for appraisal. Most of the studies were published from 2021 onwards. The overall median reporting quality score was 86%. The most frequent items not included in the studies were: a priori protocol registration (22/40 compliant; 55%), and reporting of funding (16/40 compliant; 40%). Other key elements that were inadequately reported were the abstract (7/40 compliant; 18%), the rationale and justification of the ScR (21/40 compliant; 52%) and the objectives of the study (18/40 compliant; 45%). Studies that adhered to appropriate reporting guidelines were associated with greater reporting quality scores (β‐coefficient: 10; 95%CI: 1.1, 18.9; p = .03). ScRs with protocols registered a priori had significantly greater reporting quality scores (β‐coefficient: 12.5; 95%CI: 6.1, 18.9; p < .001), compared with non‐registered reviews.The reporting quality of the ScRs in endodontics varied and was greater when the ScR protocols were registered a priori and when the authors adhered to reporting guidelines. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Tobacco smoking and its impact on pain intensity of temporomandibular disorders: A systematic review and metanalysis.
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Shetty, Amarshree A., Almalki, Sultan Abdulrahman, Al Jameel, AlBandary Hassan, Gowdar, Inderjit Murugendrappa, Ronsivalle, Vincenzo, Cicciù, Marco, and Minervini, Giuseppe
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SMOKING , *OROFACIAL pain , *DATA extraction , *DATABASE searching , *TEMPOROMANDIBULAR disorders , *ELECTRONIC information resource searching - Abstract
Background Methods Results Conclusion Temporomandibular disorders (TMDs) encompass a spectrum of orofacial conditions characterised by pain and dysfunction in the temporomandibular joint and surrounding structures. Tobacco smoking has been posited as a potential factor influencing the prevalence and intensity of TMD. However, the nature and extent of this relationship remain unclear due to variations in study outcomes. This systematic review aimed to consolidate existing research findings to elucidate the association between tobacco smoking and TMD pain intensity.A comprehensive search of electronic databases was conducted to identify relevant studies published up to June 2023. Studies investigating the relationship between tobacco smoking and TMD pain were included. Data extraction was conducted by two reviewers. Quality assessment was performed using the New Castle‐Ottawa scale. Review Manager 5.4 was used to quantitatively analyse the results.The review included four studies employing similar TMD assessment techniques. All studies reported elevated TMD pain intensity among tobacco users, with non‐smokers exhibiting lower pain intensity. The quality of the included studies was good. Meta‐analytic results showed that TMD pain intensity was higher in the smokers group compared to the non‐smokers group, with a weighted mean difference (WMD) of 0.65 (BPM) (95% CI: [0.10, 1.19], p = .02).This systematic review provides a comprehensive synthesis of the existing literature on tobacco smoking and TMD symptoms. The findings underscore the multifaceted nature of the relationship between smoking and TMD pain, highlighting its clinical relevance and the need for tailored interventions. Further research is warranted to elucidate underlying mechanisms and potential moderating factors, contributing to a more nuanced understanding of this complex association. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Color Comparison Between Intraoral Scanner and Spectrophotometer Shade Matching: A Systematic Review and Meta‐Analysis.
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Vitai, Viktória, Németh, Anna, Teutsch, Brigitta, Kelemen, Kata, Fazekas, Alíz, Hegyi, Péter, Németh, Orsolya, Kerémi, Beáta, and Borbély, Judit
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SPECTROPHOTOMETERS , *DATA extraction , *DATABASE searching , *ELECTRONIC information resource searching , *SCANNING systems - Abstract
ABSTRACT Objective Materials and Methods Results Conclusion Clinical Significance This systematic review and meta‐analysis compared the accuracy of intraoral scanners and spectrophotometers in determining tooth shade.An electronic search of five databases (PubMed, Scopus, Embase, Web of Science, CENTRAL) was conducted on October 19, 2023. A total of 163 studies were identified from the databases, of which 23 articles were eligible for inclusion. In vivo and in vitro quasi‐experimental studies were included. After data extraction, a quantitative analysis was performed to determine the accuracy of the intraoral scanner in subgroups using four outcomes: trueness and precision with different measurement locations. A random‐effects model was used to pool effect sizes. The pooled proportion with a 95% confidence interval (CI) was used for the effect size measure.Eleven articles were included in the meta‐analysis. Trueness with the intraoral scanner was between 0.28 (CI: 0.09–0.60) and 0.38 (CI: 0.24–0.53). Repeatability was between 0.81 (CI: 0.64–0.91) and 0.85 (CI: 0.74–0.92). Trueness showed low, and precision had moderate certainty of evidence.The trueness of shade matching with intraoral scanners is low compared to spectrophotometers, although the precision is considered high and is similar to spectrophotometers.Shade determination with intraoral scanners is not recommended. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Effect of omentum preservation on long-term prognosis of locally advanced gastric cancer: a systematic review and meta-analysis.
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Zhou, Xiaoshuai, Sheng, Wentao, Huang, Tongmin, and Ren, Wei
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GASTRECTOMY , *OVERALL survival , *STOMACH cancer , *OMENTUM , *DATABASE searching - Abstract
Background: The effect of omentum preservation (OP) on locally advanced gastric cancer (LAGC) remains controversial. This study aimed to investigate the long-term prognosis of LAGC patients with OP versus omentum resection (OR). Methods: A comprehensive search of databases including PubMed, Web of Science, Embase, and Cochrane Library was conducted up until February 2024. Statistical analysis was performed using Stata 12.0 software. The primary outcome was to assess the impact of OP on the long-term prognosis of patients with LAGC, including overall survival (OS) and recurrence-free survival (RFS). Results: A total of six case-control studies were included, encompassing a cohort of 1897 patients. The OP group consisted of 844 patients, while the OR group comprised 1053 patients. The study results showed that the OS (HR = 0.72, 95% CI: 0.58–0.90, P = 0.003) and 5-year RFS (HR = 0.79, 95% CI: 0.63–0.99, P = 0.038) in the OP group were superior to those observed in the OR group. Subgroup analysis indicated that 5-year OS (HR = 0.64, P = 0.003) and 5-year RFS (HR = 0.69, P = 0.005) in the OP group were also better than those in the OR group in Korea. However, the subgroup analysis conducted on stage T3-T4 tumors revealed no statistically significant differences in OS (P = 0.083) and 5-year RFS (P = 0.173) between the two groups. Conclusion: Compared with OR, OP shows non-inferiority in patients with LAGC and can be considered a potential treatment option for radical gastrectomy. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Immunogenicity of Botulinum Toxin A: Insights.
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Rahman, Eqram and Carruthers, Jean D. A.
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BOTULINUM A toxins , *BOTULINUM toxin , *IMMUNE response , *TREATMENT effectiveness , *DATABASE searching - Abstract
BACKGROUND Botulinum toxin A (BoNT-A) is widely used in treating dystonia and spasticity to managing chronic migraine and cosmetic applications. However, its immunogenic potential presents challenges, such as the development of neutralizing antibodies that lead to diminished therapeutic efficacy over time, known as secondary nonresponse. OBJECTIVE This review aims to bridge the knowledge gap regarding the immunogenic mechanisms of BoNT-A and to explore effective management strategies to mitigate these immune responses. MATERIALS AND METHODS The authors conducted a systematic search in databases including PubMed, Embase, and Web of Science, using keywords related to BoNT-A's immunogenicity. The selection process refined 157 initial articles down to 23 relevant studies, which underwent analysis to investigate the underlying mechanisms of immunogenicity and the factors influencing it. RESULTS The analysis revealed that both the neurotoxin component and the neurotoxin-associated proteins could elicit an immune response. However, only antibodies against the core toxin influence therapeutic outcomes. Various patientspecific factors such as genetic predispositions and prior immune experiences, along with treatment-related factors such as dosage and frequency, play crucial roles in shaping these responses. CONCLUSION Understanding the specific immunogenic triggers and responses to BoNT-A is critical for optimizing treatment protocols and improving patient outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Epidemiology and clinical characteristics of breast cancer in Ethiopia: a systematic review.
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Dandena, Firaol Guyassa, Teklewold, Berhanetsehay Teklemariam, Darebo, Tadele Dana, and Suga, Yisihak Debodina
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CINAHL database , *DATABASE searching , *ESTROGEN receptors , *BREAST cancer , *EPIDEMIOLOGY of cancer - Abstract
Background: According to GLOBOCAN 2020 Breast cancer is the most common cancer among women and the prevalence is increasing worldwide and in Ethiopia. This review assessed studies conducted in Ethiopia on the clinical features and epidemiology of breast cancer. Methods: Data base search conducted PubMed, Google Scholar African Journals Online (AJOL), Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Hinari without time restrictions. The search keywords included; prevalence and pattern, clinical presentation, histological and molecular subtypes, and management. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline to identify, search, extract articles, and report this systematic review. The protocol was registered in PROSPERO, ID: CRD42023403320. Results: Twenty studies were included in the review with 33,369 participants and 3 were community-based and 17 were hospital-based. In all except two reviewed studies, breast cancer is the most common cancer among women of Ethiopia. The most frequent presenting symptom was a breast lump/mass and commonly affected side was right breast. Most patients presented at a late stage and they were premenopausal age group. The commonest histology type is ductal carcinoma, that the most prevalent receptor was estrogen receptor positive, and the most common molecular subtype was Luminal A in pathology samples. Surgery is main stay of treatment and the most common surgical technique practiced in Ethiopia is modified radical mastectomy. Conclusion: Breast cancer incidence is rising, and it accounts for the major cancer burden in the country. There is a need for additional awareness-raising and health education because delayed presentation are critical problems throughout Ethiopia. For planning and monitoring cancer patterns, comprehensive demographic and clinical data from a population or facility-based registry are needed in the regions. The available treatment options are still limited in Ethiopia it needs infrastructural development. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Mapping Public Health Nursing competencies: A comparative document analysis of competency frameworks and practice standards in the USA and Ireland.
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Vickers, Niamh and Green, Chloe
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PUBLIC health nursing , *GREY literature , *CORE competencies , *DATABASE searching , *MEDICAL care - Abstract
The Public Health Nursing discipline plays a crucial role in promoting sustainable health services. The establishment of competency frameworks and practice standards pertaining to Public Health Nursing has emerged as a cornerstone for guiding practice, education, and research. This study aimed to identify contemporary Public Health Nursing competency frameworks and practice standards and establish a robust list of competency domains. This will inform a subsequent phase of this project that will conduct a review of recent scholarly literature to discern prevailing research trends and delineate strategic directives and research priorities for the discipline.A systematic search of three databases and a grey literature search was undertaken by incorporating keywords to identify existing Public Health Nursing‐specific competency frameworks and practice standards. Through screening and selection based on our inclusion criteria, three documents were analyzed. A comprehensive document analysis was conducted to generate a unified domain list and associated descriptors. Three competency‐based frameworks and practice standards emanating from two countries, the United States of America and the Republic of Ireland met the inclusion criteria. The document analysis identified 16 individual domains. There was consistent evidence of similarity across the three documents. There were minimal divergences featured within the frameworks which are discussed and compelling justifications for inclusion as universal domains are provided.This document analysis has generated a list of 16 common Public Health Nursing competency domains which will be utilized in phase two of this project as a foundational framework for the purpose of analyzing research trends, influencing research priorities, and enhancing the focal areas for future research agendas within the discipline. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Surgical Management of Hip-Spine Syndrome: A Systematic Review of the Literature.
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Lavadi, Raj Swaroop, Anand, Sharath Kumar, Culver, Lauren G., Deng, Hansen, Ozpinar, Alp, Puccio, Lauren M., Agarwal, Nitin, and Alan, Nima
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TOTAL hip replacement , *HIP osteoarthritis , *SPINAL fusion , *DEGENERATION (Pathology) , *DATABASE searching , *SPINAL surgery - Abstract
Hip-spine syndrome (HSS) was first described in 1983 to describe the symptomatology resulting from concomitant lumbar degenerative stenosis and hip osteoarthritis. Numerous studies have sought to understand the underlying pathology and appropriate management of this syndrome. The purpose of this article is to review the literature for the specific imaging characteristics and the optimal surgical treatment of HSS. A systematic review was conducted via an electronic database search through PubMed to identify all publications related to HSS. All publications that contained data on patients who underwent surgical treatment for HSS and reported patient-reported outcome measures or radiographic data were included. Exclusion criteria consisted of publications in a language other than English, review articles, and technique articles. Fifteen articles that focused on the surgical management of HSS were identified. Of these 15 articles, 8 reported radiographic outcomes, with most reporting no significant change in spinopelvic parameters before and after surgery. Thirteen articles reported clinical outcomes, with 8 of those 13 articles identifying patient-reported outcome measures to be significantly improved following surgery. The data on the surgical management of HSS remains sparse. While there is some evidence that total hip arthroplasty in patients who previously underwent spinal fusion may have higher complication rates, there remains debate regarding which surgical problem to address first, the hip or the spine. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Global knowledge and attitudes towards mpox (monkeypox) among healthcare workers: a systematic review and meta-analysis.
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Jahromi, Abdolreza Sotoodeh, Jokar, Mohammad, Sharifi, Nader, Kashkooli, Sirus, Rahmanian, Karamatollah, and Rahmanian, Vahid
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ATTITUDES of medical personnel , *RANDOM effects model , *MEDICAL personnel , *MONKEYPOX , *DATABASE searching - Abstract
Background The recent increase in human mpox (monkeypox) cases emphasizes the importance of early detection, prompt response and preventive management to control the spread of the disease. Healthcare workers (HCWs) play a crucial role in this process. This study aimed to determine the global knowledge and attitudes towards mpox among HCWs. Methods This study searched multiple databases, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web of Science, Embase, Springer and ProQuest, to locate various publications. The search was limited to English-language articles published between May 2022 (when the increase in mpox incidence was reported) and August 2023. The Joanna Briggs Institute (JBI) quality checklist was utilized to evaluate the quality of the included studies. Data were obtained using a Microsoft Excel spreadsheet and subsequently scrutinized through STATA software, version 14. The heterogeneity of the studies was assessed using the inverse variance and Cochran Q statistics based on the I 2 test statistics. The Dersimonian and Liard random effects models were used where heterogeneity existed. Subgroup analysis and univariate and multivariable metaregression techniques were used to examine the causes of heterogeneity. Results A total of 22 studies, including 22 studies for knowledge (27 731 HCWs) and 6 studies for attitudes (14 388 HCWs), were included in the meta-analysis. The pooled estimates for good knowledge and positive attitudes among HCWs were 26.0% (95% confidence interval [CI] 17.8 to 34.2) and 34.6% (95% CI 19.0 to 50.2), respectively. Moreover, the knowledge was 34.8% (95% CI 24.1 to 45.6) among HCWs with <5 y of work experience and 41.6% (95% CI 33.1 to 50) among individuals possessing >5 y of professional background. Conclusions Good knowledge of HCWs is at a low level. It is suggested that training sessions should be tailored towards younger HCWs with less healthcare experience. Additionally, it is essential to identify strategies on how to improve the knowledge and attitudes for better practice about the disease in HCWs worldwide. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Surgical nodal assessment for endometrial hyperplasia - A meta-analysis and systematic review.
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Nahshon, Chen, Leitao, Mario M., Lavie, Ofer, Schmidt, Meirav, Younes, Grace, Ostrovsky, Ludmila, Assaf, Wissam, and Segev, Yakir
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SENTINEL lymph nodes , *ENDOMETRIAL hyperplasia , *LYMPH nodes , *ENDOMETRIAL cancer , *DATABASE searching - Abstract
Endometrial intraepithelial neoplasia (EIN) and atypical hyperplasia (AH) are recognized precursors for endometrial cancer (EC). Most current guidelines do not recommend the routine surgical evaluation of lymph nodes (LN), although recent studies indicate increased use of sentinel lymph node (SLN) biopsy in patients with a preoperative diagnosis of EIN/AH. We aimed to evaluate the rates of positive LN and its effect on the incidence of upstaging of EIN/AH patients, complications, and adjuvant treatment administration. A systematic review and meta-analysis was conducted in the following databases: MEDLINE(R) using the OvidSP interface and PUBMED, Embase, Web of Science, Clinicaltrials.gov and Cochrane Library. Included were studies investigating lymph node evaluation in patients diagnosed with EIN/AH, presenting results of LN assessment and/or comparisons of hysterectomy results with and without lymph node assessment. This analysis was registered at PROSPERO International prospective register of systematic reviews (CRD42023443598). A total of 447 studies were initially identified through database searching. The current analysis includes 7 studies comprising 1791 atypical endometrial hyperplasia patients who underwent hysterectomy with lymph node assessment. The incidence of positive lymph nodes among those who had undergone any LN evaluation was found to be 1.1% (95% CI 0.3%–2%). The rate of positive LNs was 1.4% (95% CI 0.2%–1.9%) among those who had undergone specifically SLN. 319 (44.3%, 95% CI 34%–54.7%) patients of the patients initially diagnosed with EIN/AH (n = 699), were finally upgraded to EC diagnosis. Fifteen percent of the final EC diagnosed patients were treated with adjuvant treatment. No significant difference regarding complication rates was noticed. Our review indicates that the rate of metastatic LNs is <2% in patients undergoing surgical nodal evaluation for EIN/AH. However, the rate of complication for SLN mapping is low and may have an impact on postoperative therapy decisions in those diagnosed with malignancy. • We found that the rate of metastatic lymph nodes is <2% in patients undergoing surgical nodal evaluation for EIN/AH. • With that said, no significant difference regarding complication rates was noticed and overall complication rates were low. • Lymph node assessment may have an impact on postoperative therapy decisions in those diagnosed with malignancy. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Uterine perivascular epithelioid cell tumors (PEComa) and the accuracy of proposed classification systems in predicting the malignant versus non-malignant behavior.
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Garzon, Simone, Caliò, Anna, Ferrari, Filippo Alberto, Iannicello, Cesare Quintino, Zorzato, Pier Carlo, Bosco, Mariachiara, Piazzola, Elena, Martignoni, Guido, Laganà, Antonio Simone, Mariani, Andrea, and Uccella, Stefano
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TUBEROUS sclerosis , *UTERINE fibroids , *DATABASE searching , *SYMPTOMS , *SURVIVAL analysis (Biometry) , *CELL tumors - Abstract
To compare the accuracy of available classification systems (Folpe, modified Folpe, Bennet, and Schoolmester) in predicting the behavior of uterine Perivascular Epithelioid Cell tumors (PEComas). We reviewed the pathology registry to identify all uterine PEComas treated at our center. We conducted a systematic literature review searching electronic databases from inception to November 2023. We included all references reporting at least one case of uterine PEComa; cases associated with tuberous sclerosis complex were excluded. Patient-level data were extracted by identified records. Survival analysis was used to assess the accuracy of all proposed classification systems to classify uterine PEComas as malignant versus non-malignant. Six uterine PEComas were treated at our center. The literature search identified 101 uterine PEComas from 32 studies. Eighty-five out of 107 PEComas (28 studies and our series) reported enough follow-up data and details to apply all four classifications. The modified Folpe classification demonstrated the highest hazard ratio (HR) for relapse (HR:8.63; 95% confidence interval [CI] 2.06–36.1) and death due to PEComa (HR:6.8, 95%CI:0.89–51.6) for malignant versus non-malignant PEComas. Changing the cut-off of PEComa size to ≥8 cm and mitotic figures per 50 high power fields to ≥5, the HR for recurrence lowered (HR:6.26; 95% CI 2.20–17.80), but HR for death increased (HR:10.3; 95% CI 1.35–77.80). The modified Folpe classification was the most accurate in predicting the PEComa behavior. Changing the cut-off of PEComa size and number of mitotic figures may improve the accuracy in predicting death due to disease. • Uterine PEComas not associated with tuberous sclerosis complex are rare mesenchymal tumors. • Uterine PEComas have heterogeneous clinical presentation overlapping with uterine leiomyomas. • Uterine PEComas are often diagnosed after hysterectomy, and proposed adjuvant treatments are inconstant and heterogeneous. • The modified Folpe classification was the most accurate in predicting the malignant versus non-malignant behavior of PEComas. • Changing the PEComa size to ≥8 cm and number of mitotic figures per 50 high power fields to ≥5 may increase the accuracy. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Economic evaluations of therapeutic drug monitoring interventions in acute hospital‐based settings: A systematic review.
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Carland, Jane E., Carland, David J., Brett, Jonathan, Stocker, Sophie L., Roberts, Darren M., Day, Richard O., and Laba, Tracey‐Lea
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DRUG monitoring , *ECONOMIC databases , *DRUG therapy , *DATABASE searching , *TREATMENT effectiveness , *LONGITUDINAL method - Abstract
Aims: Therapeutic drug monitoring (TDM) aims to optimize drug therapy. As demand on health resources increases, and the technology underpinning TDM becomes more sophisticated, the economic benefits of TDM in hospitals is unclear. The aim of this systematic review was to summarize the economic evidence that could be used to support investment in TDM in hospital settings. In so doing, we sought to provide guidance for future economic evaluations. Methods: Medline, Embase, CENTRAL, Econlit and NHS Economic Evaluation databases were searched (inception to December 2022) for economic evaluations of hospital‐based TDM. Two authors reviewed the studies and extracted data. Overall quality of economic analysis reporting was assessed using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: Ten prospective studies (including six randomized studies) and nine retrospective studies were eligible. Overall study reporting was poor, publications meeting a median (range) of 61% (46–82%) of CHEERS checklist criteria. An antimicrobial TDM intervention for adult patients was the focus of most studies (n = 18). Variable clinical outcomes were reported, and length of stay was the primary economic outcome for most studies (n = 13). The majority of studies determined that TDM was economically and clinically favourable (n = 14), four studies reporting a cost‐reduction in patient sub‐populations. Conclusions: Significant improvements in both economic and clinical outcomes may be realized with TDM interventions, particularly when targeted to complex patient populations. Attainment of therapeutic target could serve as a feasible surrogate measure of benefit for hospital‐based TDM interventions. However, systematic reporting of economic outcomes is needed to inform investment decisions. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Infection prophylaxis among patients with antineutrophil cytoplasmic antibody (ANCA) vasculitis: a scoping review.
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Cao, Binxin, Robinson, Jacob E., Winget, Marshall, Hunt, Madison H., Carlson, Rebecca, Hogan, Susan L., Derebail, Vimal K., and Thorpe, Carolyn T.
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PNEUMOCYSTIS pneumonia , *ANTINEUTROPHIL cytoplasmic antibodies , *DATABASE design , *DATABASE searching , *RESEARCH personnel , *PNEUMOCYSTIS jiroveci - Abstract
Severe infections associated with the use of strong immunosuppressive medication are a leading cause of morbidity and mortality in patients with ANCA vasculitis (AV). While guidelines conditionally recommend trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis for Pneumocystis jirovecii pneumonia in AV patients, robust evidence on prophylaxis strategies is lacking. This scoping review aimed to assess the existing evidence on infection prophylaxis in AV patients, identify knowledge gaps, and guide future study design. A comprehensive search of six databases and relevant references identified original studies in English from January 1, 2000, to July 31, 2020. Inclusion criteria encompassed studies evaluating the impact of any antimicrobial prophylaxis strategy on infection-related outcomes in AV patients receiving immunosuppressive treatment. Studies were screened by four researchers using a blinded approach. Data was extracted by two reviewers, with differences resolved via consensus in consultation with a third reviewer. Nineteen studies met inclusion criteria, including two randomized trials and 17 cohort studies, with TMP-SMX being the most commonly assessed prophylactic strategy. The studies varied in sample sizes, outcomes measured, prophylactic strategies employed, and proportion of patients who received the regimen. Most cohort studies included no or limited control of potential confounding factors. This scoping review suggests significant variation in AV patients' receipt of TMP-SMX and alternative infection prophylaxis approaches. Observational studies using large secondary healthcare databases with rigorous designs are needed to provide high-quality evidence of the real-world effectiveness of antimicrobial prophylactic regimens, to improve clinical decision-making and quality of care for AV patients receiving immunosuppressive treatment. Key Points • This study provides a comprehensive review of infection prophylaxis strategies for AV patients regardless of the immunosuppressants used, bridging the knowledge gap from prior systematic reviews that were exclusively focused only on TMP-SMX prophylaxis or the subset of AV patients receiving rituximab. • We included all studies evaluating the effectiveness of different prophylactic strategies with careful abstraction of sub-analyses reporting on outcomes of prophylaxis, even when such analyses were not the primary objective of published study reports. • We identified an opportunity for large secondary healthcare databases and target trial emulation techniques in future research to produce robust, real-world evidence on the effectiveness of antimicrobial prophylactic regimens to enhance clinical decision-making and improve the quality of care for AV patients. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Validity of dietary assessment methods compared with doubly labeled water in children: A systematic review and meta‐analysis.
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Mehranfar, Sanaz, Jalilpiran, Yahya, Jafari, Alireza, Jayedi, Ahmad, Shab‐bidar, Sakineh, Speakman, John R., and Djafarian, Kurosh
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FOOD recall , *DRINKING (Physiology) , *FOOD consumption , *CALORIC content of foods , *DATABASE searching - Abstract
Summary: Objectives: We aimed to validate dietary assessment methods against the gold standard, doubly labeled water (DLW), for estimating total energy intake (TEI). Methods: PubMed, Scopus, Web of Science, and Google Scholar databases were searched until May 2023. Inclusion criteria encompassed studies involving participants aged 1–18 years, employing dietary assessment methods like food records, dietary histories, food frequency questionnaire (FFQ), or 24‐h recalls estimating TEI alongside DLW to measure total energy expenditure (TEE). Data were pooled using random‐effects meta‐analysis models. Results: Thirty‐three studies were identified, with sample sizes ranging from 9 to 118 participants. Meta‐analysis of 22 studies identified underestimation of TEI (mean difference [MD] = −262.9 kcal/day [95% CI: −380.0, −145.8]; I2 = 93.55%) for food records compared with TEE estimated by DLW. Other dietary assessment methods, including food recalls (n = 9) (MD = 54.2 kcal/day [95% CI: −19.8, 128.1]; I2 = 49.62%), FFQ (n = 7) (MD = 44.5 kcal/day [95% CI: −317.8, 406.8]; I2 = 94.94%), and diet history (n = 3) (MD = −130.8 kcal/day [95% CI: −455.8, 194.1]; I2 = 77.48%), showed no significant differences in TEI compared with DLW‐estimated TEE. All studies were of high quality. Conclusion: Food records may underestimate TEI, yet additional research is needed to identify the most accurate methods for assessing children's dietary intake. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Exploring factors of adherence to weight loss interventions in population with overweight/obesity: an umbrella review.
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Wang, Deng, Benito, Pedro J., Rubio‐Arias, Jacobo Á., Ramos‐Campo, Domingo J., and Rojo‐Tirado, Miguel A.
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WEIGHT loss , *PHYSICAL activity , *DRUG therapy , *RESEARCH personnel , *DATABASE searching - Abstract
Summary: Adherence is key for achieving the optimal benefits from a weight loss intervention. Despite the number of studies on factors that promote adherence, their findings suggest inconsistent and fragmented evidence. The aim of this study was to review the existing factors of adherence to weight loss interventions and to find factors that facilitate the design of effective intervention programs. Six databases were searched for this umbrella review; after the screening process, 21 studies were included. A total of 47 factors were identified in six groups as relevant for adherence: (i) sociodemographic (n = 7), (ii) physical activity (n = 2), (iii) dietary (n = 8), (iv) behavioral (n = 4), (v) pharmacological (n = 3), and (vi) multi‐intervention (n = 23). In addition, a map of adherence factors was created. The main findings are that with respect to demographic factors, the development of personalized intervention strategies based on the characteristics of specific populations is encouraged. Moreover, self‐monitoring has been shown to be effective in behavioral, dietary, and multi‐interventions, while technology has shown potential in dietary, behavioral, and multi‐interventions. In addition, multi‐interventions are adherence‐promoting strategies, although more evidence is required on adherence to pharmacological interventions. Overall, the factor map can be controlled and modified by researchers and practitioners to improve adherence to weight loss interventions. [ABSTRACT FROM AUTHOR]
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- 2024
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19. The efficacy of orthokeratology lenses with smaller back optic zone diameter in myopia control. A meta‐analysis.
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Zhou, Yongli, Li, Huan, Hao, Jiangdong, Pan, Wei, Yang, Zhikuan, and Lan, Weizhong
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REFRACTIVE errors , *MYOPIA , *DATABASE searching , *RESEARCH personnel , *ORTHOKERATOLOGY - Abstract
Purpose: This study was conducted to determine whether orthokeratology (OK) lenses with a smaller back optic zone diameter (BOZD) could exhibit stronger myopia control effects. Method: A meta‐analysis was registered in PROSPERO (CRD42023408184). A comprehensive systematic database search was conducted, encompassing PubMed, Cochrane Library, EMBASE, MEDLINE, Web of Science, Ovid, CNKI and CBM, to identify relevant studies up to 25 March 2023. The primary inclusion criteria for this meta‐analysis were studies that investigated the myopia control effect of OK lenses with a small optical treatment area (≤5 mm). To assess the quality of the retrieved articles, two researchers evaluated them using the Cochrane bias risk assessment criteria. The primary outcome measures were the changes in axial length (AL) and refractive error, using the weighted mean differences (WMD) and 95% confidence intervals (CI) to assess differences between small and traditional back optical treatment zone groups in terms of these outcomes. Results: The analysis encompassed five eligible studies, with a 1 year duration. The average difference in AL between the groups was 0.12 mm (WMD = −0.12, 95% CI [−0.16, −0.09], p < 0.00001). Likewise, the average difference in refractive error between the two groups was 0.44 D (WMD = 0.44, 95% CI [0.30, 0.57], p < 0.00001). None of the studies reported severe adverse events. Conclusions: Current evidence suggests that OK lenses with smaller back optical treatment zone are more effective in preventing myopia progression than traditional lenses. However, a longer‐term evaluation is warranted. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Use of Goals in Cancer Pain Management: A Systematic Review.
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Ehrlich, Olga, Lackowski, Alyssa, Glover, Toni L., and Vallerand, April Hazard
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PAIN measurement , *PAIN management , *MOTIVATIONAL interviewing , *CINAHL database , *DATABASE searching , *CANCER pain - Abstract
Cancer pain is multidimensional and management should be individualized to patient goals. The current standard for pain goal assessment is the personal pain goal (PPG), a numeric rating for tolerable pain intensity. However, the PPG may not accurately capture a personally meaningful goal for tailoring pain management. Identify how pain goals are used in cancer pain management and types of goals researched. CINAHL, PsychInfo, and PubMed databases and manual searching were used to locate research or scholarship about cancer pain goals. Authors reviewed titles, abstracts and full text to agree on the final sample. Sixteen articles met inclusion criteria. Study designs included: quality improvement project (1), concept analysis (1), qualitative methods (5), quantitative methods (8), and mixed methods (1). Findings included: goal setting as a key attribute of pain management; achieving personal goals as the outcome of pain management work; qualitative themes discussed personal goals related to pain management; developing a patient pain management resource including a SMART goal; using motivational interviewing to set functional pain goals; PPG assessment was feasible; and achieving PPG equated to having controlled pain when compared to the clinically important difference measure used in research (≥30%). Quantitative studies reported on PPGs only. Currently, assessments for cancer pain goals do not include function, activities, moods, medication effects, or safety that patients wish to achieve as a pain management outcome. Development and testing of multidimensional patient pain goals assessments is warranted so that goals can be consistently assessed, documented, and personally meaningful. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Flexible ureteroscopic incision and drainage or laparoscopic unroofing for the parapelvic renal cysts: A systematic review and meta-analysis.
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JIANGUO GAO, MENG ZHANG, JIANER TANG, RONGJIANG WANG, YU CHEN, ZHIHAI FANG, and HUAN ZHONG
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CYSTIC kidney disease , *MEDICAL drainage , *URETEROSCOPY , *LENGTH of stay in hospitals , *DATABASE searching - Abstract
The aim of the present study was to compare flexible ureteroscopy and laparoscopy in the treatment of peripelvic renal cysts, so as to determine the best treatment method for patients with peripelvic renal cysts. A systematic search of the PubMed, EMBASE, Cochrane Library, CONAHL, Clinicaltrials.gov, Google Scholar, CNKI and WanFang DATA databases was conducted for articles published over 22 years (December 1980-December 2022) using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. By searching the database, a total of 594 studies were found, of which eight were analyzed as evidence. A total of 394 patients were included in the present study. Of these, 193 were treated laparoscopically and 201 were treated by flexible ureteroscopy. In terms of analysis results, radiation reexamination after laparoscopic therapy had a higher success rate. Ureteroscopy has advantages in the time spent in the operation, the amount of blood lost during the operation, the time to recover the anal exhaust after the operation and the length of postoperative hospital stay. There were no significant difference in postoperative recurrence or complications between the two surgical methods. After comprehensive analysis, it was considered that flexible ureteroscopy has more advantages in the treatment of peripelvic renal cyst, which is mainly manifested in the duration of operation, the total amount of blood loss during operation, the interval of recovery of anal exhaust after operation and the total length of postoperative hospital stay. It is worth further exploration and promotion. [ABSTRACT FROM AUTHOR]
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- 2024
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22. A meta‐analysis of coping strategies and psychological distress in rheumatoid arthritis.
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Hinch, Rebecca and Sirois, Fuschia M.
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PSYCHOLOGICAL adaptation , *RHEUMATOID arthritis , *DISEASE duration , *DATABASE searching , *ANXIETY , *PSYCHOLOGICAL distress - Abstract
Purpose: Theory and research indicate that coping plays a central role in the experience of psychological distress in people with rheumatoid arthritis (RA). This study meta‐analysed the associations of adaptive and maladaptive coping strategies with psychological distress in people with RA to quantify and better understand the proposed differential relationships, as well as the factors that might influence these links. Methods: Searches of four databases identified eligible studies according to a pre‐registered protocol. Two random effects meta‐analyses examined the direction and magnitude of the links between adaptive coping (problem‐focused and emotional approach coping) and maladaptive coping (emotional avoidance and pre‐occupation coping) and psychological distress (stress, anxiety, and depression). Study quality was evaluated using a bespoke tool. Moderator analyses for sample characteristics and distress type were conducted. Results: Searches identified 16 eligible studies with 46 effects. Meta‐analysis of maladaptive coping and distress yielded a significant, medium sized association, k = 12, r =.347, 95% CIs [.23,.46]. Moderator analyses were significant only for type of distress, with effects for depression being larger than that for combined distress. Effects did not vary as a function of age, participant sex, or disease duration. Meta‐analysis for adaptive coping was not significant, k = 10, r = −.155, 95% CIs [−.31,.01]. Conclusions: Findings from this first meta‐analysis of coping and distress in RA indicate that maladaptive but not adaptive coping is associated with greater distress. Further research is needed to grow the evidence base to verify the current findings especially with respect to adaptive coping. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Key characteristics of effective yoga interventions for managing osteoarthritis: a systematic review and meta-analysis.
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Biswas, Isha, Nalbant, Gamze, Lewis, Sarah, and Chattopadhyay, Kaushik
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JOINT pain , *RANDOMIZED controlled trials , *YOGA , *CONFIDENCE intervals , *DATABASE searching - Abstract
This systematic review aimed to synthesise the content, structure, and delivery characteristics of effective yoga interventions for managing osteoarthritis symptoms, including joint pain and joint function. JBI guidelines were followed. 17 databases were searched for randomised controlled trials (RCTs) assessing yoga's effectiveness on osteoarthritis symptoms. Meta-analyses and a narrative synthesis were conducted to address the objective. The systematic review and meta-analysis included 18 and 16 articles (representing 16 and 14 RCTs), respectively. Overall, the included studies had low methodological quality scores. 10 of 14 yoga interventions effectively reduced pain (standardised mean difference (SMD) − 0.70; 95% confidence interval (CI) − 1.08, − 0.32) and/or improved function (− 0.40; − 0.75, − 0.04). Notably, 8 effective interventions had centre-based (supervised, group) sessions, and 6 included additional home-based (unsupervised, individual) sessions. Effective interventions included 34 yogic poses (12 sitting, 10 standing, 8 supine, 4 prone), 8 breathing practices, and 3 meditation and relaxation practices. 8 interventions included yogic poses, and 7 also incorporated breathing practices and/or meditation and relaxation practices. 4 interventions included yogic pose modifications for osteoarthritis. The median duration of centre-based sessions was 8 weeks and each session was around 53 min, mostly delivered once a week. The median duration of home-based sessions was 10 weeks and each session was 30 min, usually instructed to practice 4 times a week. Given previous studies' limitations, a high-quality long-term RCT should be conducted using synthesised findings of previous effective yoga interventions. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy: a meta-regression analysis.
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Binda, Cecilia, Dajti, Elton, Giuffrida, Paolo, Trebbi, Margherita, Coluccio, Chiara, Cucchetti, Alessandro, Fugazza, Alessandro, Perini, Barbara, Gibiino, Giulia, Anderloni, Andrea, Repici, Alessandro, and Fabbri, Carlo
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PATIENT selection , *MEDICAL drainage , *DATABASE searching , *CHOLANGITIS , *SEPSIS - Abstract
Background Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is a valid option for EUS-guided biliary drainage that has been increasingly used in the last decade. The aims of this study were to provide a systematic review with meta-analysis and meta-regression of the features and outcomes of this procedure. Methods The MEDLINE, Scopus, Web of Science, and Cochrane databases were searched for literature pertinent to EUS-HGS. Meta-analysis of the proportions and meta-regression of potential modifiers of the main outcome measures were applied. The main outcome was technical success; secondary outcomes were clinical success and procedure-related adverse events (AEs). Results 33 studies, including 1644 patients, were included in the meta-analysis. Malignant biliary obstruction (MBO) was the underlying cause in almost all cases (99.6%); the main indications for EUS-HGS were duodenal/papillary invasion (34.8%), surgically altered anatomy (18.4%), and hilar stenosis (16.0%). The pooled technical success of EUS-HGS was 97.7% (95%CI 96.1%–99.0%; I2 = 0%), the intention-to-treat clinical success rate was 88.1% (95%CI 84.7%–91.2%; I2 = 33.9%), and procedure-related AEs occurred in 12.0% (95%CI 9.8%–14.5%; I2 = 20.4%), with cholangitis/sepsis (2.8%) and bleeding (2.3%) the most frequent. The rate of procedure-related AEs was lower with the use of dedicated stents on univariable meta-regression analysis. Meta-regression showed that technical success and clinical success rates were modified by the centers' experience (>4/year). Conclusions EUS-HGS represents an effective and safe procedure for EUS-guided biliary drainage in patients with MBO. Future studies should address the impact of center experience, patient selection, and the use of dedicated stents to improve performance of this technique. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Robotic versus laparoscopic liver resection for posterosuperior segments: a systematic review and meta-analysis.
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Liang, Bin, Peng, Yufu, Yang, Wugui, Yang, Yubo, Li, Bo, Wei, Yonggang, and Liu, Fei
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SURGICAL blood loss , *LAPAROSCOPIC surgery , *DIGITAL libraries , *BLOOD transfusion , *DATABASE searching - Abstract
Minimally invasive hepatectomy for difficult lesions located in posterosuperior segments (segments I, IVa, VII and VIII) remains challenging. The value of robotic liver resection (RLR) compared with laparoscopic liver resection (LLR) for posterosuperior segments is controversial. Therefore, we performed this meta-analysis to validate the safety and efficacy of RLR in posterosuperior segments. The Medline, Embase, Web of Science, and Cochrane Library electronic databases were searched to identify available research published up to October 2023. Statistical analysis was performed with RevMan software version 5.3. Six studies with a total of 2289 patients (RLR: n = 749; LLR: n = 1540) were included in this meta-analysis. The RLR group had less intraoperative blood loss (WMD = −119.54 ml, 95% CI: −178.89 to −60.19, P < 0.0001), fewer blood transfusions (OR = 0.56, 95% CI: 0.39 to 0.80, P = 0.001), a lower conversion rate (OR = 0.37, 95% CI: 0.23 to 0.61, P < 0.0001), and a shorter operative time (WMD = −27.16 min, 95% CI: −35.95 to −18.36, P < 0.00001). Compared with LLR, RLR for lesions in the posterosuperior segments could be safe and effective, and it has superior surgical outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Maintaining Meaningful Human Interaction in AI-Enhanced Language Learning Environments: A Systematic Review.
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Saeed Omer, Neimat Idris Moh.
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ARTIFICIAL intelligence ,INDIVIDUALIZED instruction ,HUMAN-computer interaction ,DATABASE searching ,SOCIAL interaction - Abstract
Copyright of Arts for Linguistic & Literary Studies is the property of Thamar University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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27. Chain-imprimitive, flag-transitive 2-designs.
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Amarra, Carmen, Devillers, Alice, and Praeger, Cheryl E.
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ELECTRONIC information resource searching ,DATABASE searching ,BLOCK designs ,AUTOMORPHISMS ,MAGMAS - Abstract
We consider 2-designs which admit a group of automorphisms that is flag-transitive and leaves invariant a chain of nontrivial point-partitions. We build on our recent work on 2-designs which are block-transitive but not necessarily flag-transitive. In particular we use the concept of the "array" of a point subset with respect to the chain of point-partitions; the array describes the distribution of the points in the subset among the classes of each partition. We obtain necessary and sufficient conditions on the array in order for the subset to be a block of such a design. By explicit construction we show that for any s ≥ 2 , there are infinitely many 2-designs admitting a flag-transitive group that preserves an invariant chain of point-partitions of length s. Moreover an exhaustive computer search, using Magma, seeking designs with e 1 e 2 e 3 points (where each e i ≤ 50 ) and a partition chain of length s = 3 , produced 57 such flag-transitive designs, among which only three designs arise from our construction—so there is still much to learn. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Evidence of efficacy the various management methods in paraquat poisoning: an umbrella review.
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Shahsavarinia, Kavous, Balafar, Moloud, Tahmasbi, Fateme, Gharekhani, Afshin, Milanchian, Nooshin, Hajipoor Kashgsaray, Nasim, Maham, Marzieh, and Salehi-Pourmehr, Hanieh
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PARAQUAT ,IMMUNOSUPPRESSIVE agents ,DEATH rate ,POISONING ,DATABASE searching - Abstract
This umbrella review presents different therapeutic approaches for Paraquat (PQ) poisoning to reach a general conclusion on what is the best treatment to reduce mortality. A comprehensive electronic search of relevant databases was conducted from inception to April 2022. Only systematic reviews with or without meta‐analysis were eligible for this review. Initially, 123 titles were retrieved, and after removing the duplicates, 89 titles and abstracts were reviewed. Finally, 34 full texts were screened, and of these, 11 qualitative systematic reviews and quantitative meta-analyses (including 12 trials) were eligible. The mortality rate following all included interventions was 24% less likely to occur than in routine management (RR: 0.763, 95% CI 0.649–0.897; p = 0.001). In subgroup analysis, the efficacy of immunosuppressive therapy and Ambroxol was higher than other interventions. The mortality rate following Ambroxol was 31% less likely to occur than routine management (RR: 0.690, 95% CI 0.552–0.863; p = 0.001). This rate was similar to the immunosuppressive therapy (RR: 0.700, 95% CI: 0.627–0.782; p < 0.001). Other interventions did not affect the reduction of the mortality rate (p > 0.05). To conclude the accurate result, further studies are recommended to evaluate the efficacy and safety of immunosuppressive therapy. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Prevalence of cerebral visual impairment in developmental and Epileptic Encephalopathies: a systematic review protocol.
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Perinelli, Martina Giorgia, Abbott, Megan, Balagura, Ganna, Riva, Antonella, Amadori, Elisabetta, Verrotti, Alberto, Demarest, Scott, and Striano, Pasquale
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SEIZURES (Medicine) , *GENETIC disorder diagnosis , *DATABASE searching , *PEOPLE with epilepsy , *EPILEPSY - Abstract
Background: Developmental and Epileptic Encephalopathies (DEEs) are defined by drug-resistant seizures and neurodevelopmental disorders. Over 50% of patients have a genetic cause. Studies have shown that patients with DEEs, regardless of genetic diagnosis, experience a central visual function disorder known as Cerebral (cortical) Visual Impairment (CVI). The prevalence of CVI in DEE patients is currently unknown. A quantitative synthesis of existing data on the prevalence rates of this condition would aid in understanding the magnitude of the problem, outlining future research, and suggesting the need for therapeutic strategies for early identification and prevention of the disorder. Methods: The protocol followed the PRISMA-P statement for systematic review and meta-analysis protocols. The review will adhere to the JBI Manual for Evidence Synthesis (Systematic Reviews of Prevalence and Incidence) and use the CoCoPop framework to establish eligibility criteria. We will conduct a comprehensive search of several databases, including MEDLINE, EMBASE, Science Direct, Scopus, PsychINFO, Wiley, Highwire Press, and Cochrane Library of Systematic Reviews. Our primary focus will be determining the prevalence of cerebral visual impairments (Condition) in patients with developmental and epileptic encephalopathy (Population). To ensure clarity, we will provide a narrative summary of the risk of bias in the studies we include. The Cochrane Q statistic will be used to assess heterogeneity between studies. If the quantitative synthesis includes more than 10 studies, potential sources of heterogeneity will be investigated through subgroup and meta-regression analyses. Meta(bias)es analysis will also be performed. The quality of evidence for all outcomes will be evaluated using the Grading of Recommendations Assessment Development and Evaluation (GRADE) working group methodology. Discussion: This protocol outlines a systematic review and meta-analysis to identify, collect, evaluate, and integrate epidemiological knowledge related to the prevalence of CVI in patients with DEEs. To the best of our knowledge, no other systematic review and meta-analysis has addressed this specific issue. The results will provide useful information for understanding the extent of the problem, outlining future research, and suggesting the need for early identification strategies. Systematic review registrations: This Systematic Review Protocol was registered in PROSPERO (CRD42023448910). [ABSTRACT FROM AUTHOR]
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- 2024
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30. Meta-analysis of the dosage of balance training on ankle function and dynamic balance ability in patients with chronic ankle instability.
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Tang, Fang, Xiang, Meng, Yin, Shanshan, Li, Xiang, and Gao, Pincao
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CHRONIC ankle instability , *DYNAMIC balance (Mechanics) , *DATABASE searching , *ANKLE , *SUBGROUP analysis (Experimental design) - Abstract
Objective: To explore and compare the dosage of balance training on ankle function and dynamic balance ability in patients with chronic ankle instability (CAI). Methods: The PubMed, Embase, Web of Science, Medline, and Cochrane databases were searched up to December 2023. Quality assessment was carried out using the risk-of-bias guidelines of the Cochrane Collaboration, and the standardized mean differences (SMD) or mean differences (MD) for each outcome were compute. Results: Among 20 eligible studies, including 682 participants were analyzed in this meta-analysis. The results of the meta-analysis demonstrated that balance training was effective in enhancing ankle function with self-functional scores (SMD = 1.02; 95% CI, 0.61 to 1.43; p < 0.00001; I2 = 72%) and variables associated with the ability of dynamic balance such as SEBT-A (MD = 5.88; 95% CI, 3.37 to 8.40; p < 0.00001; I2 = 84%), SEBT-PM (MD = 5.47; 95% CI, 3.40 to 7.54; p < 0.00001; I2 = 61%), and SEBT-PL (MD = 6.04; 95% CI, 3.30 to 8.79; p < 0.0001; I2 = 79%) of CAI patients. Meta-regression indicated that the intervention time might be the principal cause of heterogeneity (p = 0.046) in self-functional scores. In subgroup analyses of self-functional score across intervention types, among the intervention time, more than 20 min and less than 30 min had the most favorable effect (MD = 1.21, 95% CI: 0.96 to 1.46, p < 0.00001, I2 = 55%); among the intervention period, 4 weeks (MD = 0.84, 95% CI: 0.50 to 1.19, p < 0.00001, I2 = 78%) and 6 weeks (MD = 1.21, 95% CI: 0.91 to 1.51, p < 0.00001, I2 = 71%) had significant effects; among the intervention frequency, 3 times (MD = 1.14, 95% CI: 0.89 to 1.38), p < 0.00001, I2 = 57%) had significant effects. Secondly, in subgroup analyses of SEBT across intervention types, a 4-week and 6-week intervention with balance training 3 times a week for 20–30 min is the optimal combination of interventions to improve SEBT (dynamic balance) in patients with chronic ankle instability. Conclusion: Balance training proves beneficial for ankle function in patients with CAI. Intervention time constitutes a major factor influencing self-function in patients with CAI. It is recommended that the optimal dosage of balance training for CAI involves intervention three times a week, lasting for 20 to 30 min over a period of 4 to 6 weeks for superior rehabilitation. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Why do preconception and pregnancy lifestyle interventions demonstrate limited success in preventing overweight and obesity in children? A scoping review investigating intervention complexity, process evaluation components, and author interpretations.
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Philippe, Kaat, Teo, Shevaun M., Perrotta, Carla, McAuliffe, Fionnuala M., and Phillips, Catherine M.
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OVERWEIGHT children , *CHILDHOOD obesity , *THEMATIC analysis , *DATABASE searching , *SAMPLE size (Statistics) - Abstract
Summary Preventing childhood obesity from early life is considered essential. However, evidence from recent systematic reviews has highlighted inconsistent results and limited effectiveness of preconception and pregnancy lifestyle interventions regarding offspring weight outcomes and adiposity. Therefore, to improve our understanding regarding the mixed success of these early life interventions, we conducted a scoping review examining intervention complexity, process evaluation components, and authors' statements. Eligible articles (preconception or pregnancy lifestyle trials with offspring data beyond 1 month of age) were identified by searching databases (PubMed, Embase, and CENTRAL), previous reviews, and performing CLUSTER searches. The Intervention Complexity Assessment Tool for Systematic Reviews (iCAT_SR) was used to evaluate intervention complexity. A thematic analysis provided insight into process evaluation components and authors' interpretations. Finally, an expert consultation on the results was conducted. We identified 40 eligible publications corresponding to 27 trials. Only two trials started before conception. Potential reasons for interventions' limited success included the late intervention initiation, short intervention duration, and insufficient sample size. Few studies reported process evaluations and included stakeholder involvement, which are essential according to the expert group. We discuss current limitations and outline suggestions for future interventions in this field of research. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Review article: Back to life from being declared dead in the Resus Bay: An integrative review of the phenomenon of autoresuscitation and learning for ED.
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Manton, Joanna
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LITERATURE reviews , *RETURN of spontaneous circulation , *CARDIAC arrest , *DATABASE searching , *ENGLISH language - Abstract
This is a literature review of ED autoresuscitation. The impetus for this review was a case which revealed a lack of understanding about Lazarus syndrome among ED staff. The primary objective was to see the proportion of cases who survived neurologically intact to discharge and the time frame when this occurred after death had been declared. A secondary outcome was to see whether these studies mention whether bedside echo was performed prior to deciding whether to terminate resuscitation. A systematic search of five databases was undertaken with keywords, ‘autoresuscitation’, ‘cardiac arrest’ and ‘emergency department’. Articles published in the English language were selected for inclusion. No time frame was selected because of the low number of articles. A total of 240 articles were identified, that yielded 26 cases that were relevant and could be synthesised to create a discussion on the current clinical guidelines around resuscitation. Our analysis demonstrates that of the 11 survivors who were discharged neurologically intact, the average age was 42.9 years; otherwise, the average was 62.6 years. The majority (23/26) 88% auto‐resuscitated within 10 min after being pronounced dead. Only five patients are mentioned as having had a bedside echo prior to deciding to cease efforts. Under‐reporting of autoresuscitation is suspected because of fears of blame. Passive monitoring for 10 min after resuscitation is ceased, is recommended. There is need for more data on this phenomenon to help inform further research on the topic. [ABSTRACT FROM AUTHOR]
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- 2024
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33. The translatability of communication interventions in paediatric autism: A scoping review.
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Sandham, Victoria, Hill, Anne E., Hinchliffe, Fiona, and Armstrong, Rebecca M.
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AUTISM spectrum disorders , *AUTISTIC children , *LITERATURE translations , *DEMOGRAPHIC characteristics , *SPEECH therapists , *DATABASE searching - Abstract
AbstractPurposeMethodResultConclusionTranslation of research is requisite for speech-language pathologists; however, barriers have been reported. This review aimed to identify the extant literature published on communication for autistic children, and examine the replicability and translatability of communication interventions for speech-language pathologists providing services to children with autism.A scoping review was conducted using a six-stage protocol. Following initial database searching and screening, data were extracted from included studies for demographic characteristics and Template for Intervention Description and Replication (TIDieR) checklist elements. Stakeholder consultation interviews with 13 speech-language pathologists who work with autistic children were also undertaken.The database search revealed 4719 studies on the topic of communication in autistic children, of which 762 were communication intervention studies. Of these included intervention studies, 30% were considered replicable according to the TIDieR checklist. Stakeholder consultation revealed that poorly described intervention studies hindered translation efforts.The vast amount of autism communication intervention literature and the variable quality of intervention description reporting are barriers to accessing high quality literature for translation to practice. Improved reporting of intervention descriptions in autism communication intervention studies would support research translation into clinical settings. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Prognostic and clinicopathological value of systemic immune-inflammation index in patients with osteosarcoma: a meta-analysis.
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Xiaoyan Wang, Zhong Wu, Zongxin Zhang, and Ziwei Jiang
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OVERALL survival ,SPONTANEOUS fractures ,PROGNOSIS ,EVIDENCE-based medicine ,DATABASE searching - Abstract
Background: The efficiency of systemic immune-inflammation index (SII) in predicting prognosis of osteosarcoma (OSA) patients has been extensively analyzed, but no consistent findings are obtained. Therefore, this meta-analysis focused on identifying the precise prognostic value of SII for OSA. Methods: We comprehensively searched electronic databases of PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) from inception to 24 February, 2024. Meanwhile, the efficiency of SII in predicting prognosis of OSA was evaluated by calculating pooled hazard ratios (HRs) as well as 95% confidence intervals (CIs). Additionally, the correlation of SII with the OSA clinicopathological characteristics was analyzed based on pooled odds ratios (ORs) and 95%CIs. Results: Six studies with 1015 cases were enrolled into this work. According to the combined data, the higher SII was markedly related to poor overall survival (OS) (HR=2.01, 95%CI=1.30-3.09, p=0.002) and Enneking stage III (OR=2.21, 95% CI=1.11-4.39, p=0.024) of patients with OSA. Nonetheless, SII was not significantly related to gender, age, pathological fracture, tumor size, tumor location, tumor differentiation, and metastasis in patients with OSA. Conclusions: In summary, the higher SII is markedly related to poor OS and advanced Enneking stage in OSA patients. [ABSTRACT FROM AUTHOR]
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- 2024
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35. The Z-scores of cardiac indices among healthy children: a systematic review and meta-analysis.
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Chinawa, Josephat M., Chinawa, Awoere T., Chukwu, Bartholomew F., and Peter, Igoche D.
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HEART size ,PULMONARY valve ,BODY surface area ,MITRAL valve ,DATABASE searching - Abstract
Background: The application of z-scores in normalizing the cardiac size function and structural dimension will be of immense benefit to the clinician, especially in evaluating children with cardiac anomalies. However, heterogeneity in the obtained z- score results is high, thus a subgroup analysis by region (or continent) to assist healthcare practitioners is necessary. Objectives: The review aimed to ascertain the overall mean z-scores for cardiac structures and function. Methods: A thorough search of several databases, EMBASE, PubMed/MEDLINE, and Google Scholar was made. Articles published between January 1999 and December 2023 were recruited, of which the last search was done in December 2023. Keywords used in the search were "z-scores", Children; echocardiography; cardiac structures; cardiac function; and body surface area (BSA)". We restricted our search to children. Besides, additional relevant articles were manually searched. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was used to highlight selected studies using a pre-defined search protocol. The I
2 statistics were used to ascertain statistical heterogeneity. Results: Two hundred and forty citations were identified in our search strategy, of which a total of 34 studies were identified. Twenty-four were excluded from the thirty-four studies. A total of 11 studies met our inclusion criteria shown in the PRISMA. Apart from different z scores reading obtained from various countries and regions, some authors focused on few cardiac parameters while others were exhaustive. The mean z-scores of the cardiac structures from various countries/regions range as follows; The range of Z scores obtained by different studies and regions above are as follows; MV;-1.62-0.7 AV: -1.8 -0.5 TV: -2.71 -0.7; PV ; -1.52- (-0.99) MPA; -1-81 -0.8 LPA;-1.07-0.4; RPA;-0.92- 0.1 IVSD; -0.1.77–1.89 LVPWD; -0.12-1.5 LVPWS; -0.1-0.15 LVPWS; 0.03–0.18 LVIDD; -1.13- (-0.98) LVIDS; -0.84-10.3 respectively. The mean z-score from the pooled studies showed mitral valve diameter as -0.24 ± 0.9 and pulmonary valve annuls as -1.10 ± 0.3. The left ventricular end diastolic diameter is -0.93 ± 0.3 while the left ventricular end systolic diameter is -0.05 ± 0.5. The total pooled sample size of the eleven included studies was 9074 and the mean at 95% interval was 824.9 ± 537.344. The pooled mean is presented under the model of the Mean raw (MRAW) column. The heterogeneity discovered among the selected studies was statistically significant. Conclusion: Due to heterogeneity involved in the reportage of the z-scores of cardiac structures and function, it may be necessary for every region to use their z-scores domiciled in their locale. However, having a pooled mean z-score of cardiac structures and function may be useful in the near future. [ABSTRACT FROM AUTHOR]- Published
- 2024
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36. BIOMEHANICAL AND POSTURAL EVALUATION OF OPTIMAL BIKE FIT FOR NON-TRAUMATIC INJURY PREVENTION AMONG CYCLISTS: A NARRATIVE REVIEW.
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Miraj, Mohammad, Gupta, Aparna, Kalra, Sheetal, Khanna, Archana, and Ajmera, Puneeta
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OVERUSE injuries , *CYCLING injuries , *CYCLING , *PUBLISHED articles , *DATABASE searching - Abstract
This review article assesses the evidence for the efficacy of bike fit and its impact on cyclist’s posture in averting overuse injuries in cycling and provides a summary of research using a biomechanical approach to give evaluations of joint kinematics, kinetics, or muscle activity. Databases were searched for published material like Medline, Scopus, Web of Science, and Google Scholar between 1980 and 2023. Posture, bike fit, and biomechanics of cycling were few keywords used. Twenty-four published articles were included in this review. Clearance of 1–2 inches should be present between the ground and tyres when the bike is lifted while straddling it, for straight and parallel to ground top tubes and sloping top tubes, respectively. Handlebar height should be 1–2 inches below the top of the saddle. The reach of the handlebars should be measured by placing an elbow on the tip of saddle and extended fingers should touch the transverse part of the handlebars. The ball of foot should sit over the pedal axis. In cyclist’s seated position, the knee flexion angle of the extended leg at 6 o’clock position should be 25–30∘. With pedals at 3 and 9 o’clock, the front of the patella should be directly in line with the front of the crank arm. About 10 to 15∘ anterior saddle tilt significantly reduces low back discomfort. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Initial treatment choices for long‐term remission of chronic insomnia disorder in adults: a systematic review and network meta‐analysis.
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Furukawa, Yuki, Sakata, Masatsugu, Furukawa, Toshiaki A., Efthimiou, Orestis, and Perlis, Michael
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SLEEP duration , *COGNITIVE therapy , *INSOMNIA , *ODDS ratio , *DATABASE searching - Abstract
Background Methods Findings Interpretation We aimed to evaluate the comparative efficacy and acceptability of cognitive behavioral therapy for insomnia (CBT‐I), pharmacotherapy, and their combination in the long and short terms among adults with chronic insomnia disorder.We searched multiple databases to December 27, 2023. We included trials in hypnotic‐free adults with chronic insomnia comparing at least two of CBT‐I, pharmacotherapy, or their combination. We assessed the confidence in evidence using CINeMA. The primary outcome was long‐term remission. Secondary outcomes included all‐cause dropout and self‐reported sleep continuity measures in the long term, and the same outcomes in the short term. We performed frequentist random‐effects network meta‐analyses (CRD42024505519).We identified 13 trials including 823 randomized participants (mean age, 47.8 years; 60% women). CBT‐I was more beneficial than pharmacotherapy in the long term (median duration, 24 weeks [range, 12 to 48 weeks]; remission odds ratio, 1.82 [95% confidence interval (CI), 1.15–2.87]; [certainty of evidence: high]), while there was weaker evidence of benefit of combination against pharmacotherapy (1.71 [95% CI, 0.88–3.30: moderate]) and no clear difference of CBT‐I against combination (1.07 [95% CI, 0.63–1.80: moderate]). CBT‐I was associated with fewer dropouts than pharmacotherapy. Short‐term outcomes favored CBT‐I over pharmacotherapy except total sleep time. Given the average long‐term remission rate in the pharmacotherapy‐initiating arms of 28%, CBT‐I resulted in a long‐term remission rate of 41% (95% CI, 31%–53%) and combination 40% (95% CI, 25%–56%).The current study found that starting with CBT‐I for chronic insomnia leads to better outcomes than pharmacotherapy. Combination may be better than pharmacotherapy alone, but unlikely to be worth the additional burden over CBT‐I alone. [ABSTRACT FROM AUTHOR]
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- 2024
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38. User engagement in clinical trials of digital mental health interventions: a systematic review.
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Elkes, Jack, Cro, Suzie, Batchelor, Rachel, O'Connor, Siobhan, Yu, Ly-Mee, Bell, Lauren, Harris, Victoria, Sin, Jacqueline, and Cornelius, Victoria
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RANDOMIZED controlled trials , *DIGITAL health , *MENTAL illness , *DATABASE searching , *MENTAL health - Abstract
Introduction: Digital mental health interventions (DMHIs) overcome traditional barriers enabling wider access to mental health support and allowing individuals to manage their treatment. How individuals engage with DMHIs impacts the intervention effect. This review determined whether the impact of user engagement was assessed in the intervention effect in Randomised Controlled Trials (RCTs) evaluating DMHIs targeting common mental disorders (CMDs). Methods: This systematic review was registered on Prospero (CRD42021249503). RCTs published between 01/01/2016 and 17/09/2021 were included if evaluated DMHIs were delivered by app or website; targeted patients with a CMD without non-CMD comorbidities (e.g., diabetes); and were self-guided. Databases searched: Medline; PsycInfo; Embase; and CENTRAL. All data was double extracted. A meta-analysis compared intervention effect estimates when accounting for engagement and when engagement was ignored. Results: We identified 184 articles randomising 43,529 participants. Interventions were delivered predominantly via websites (145, 78.8%) and 140 (76.1%) articles reported engagement data. All primary analyses adopted treatment policy strategies, ignoring engagement levels. Only 19 (10.3%) articles provided additional intervention effect estimates accounting for user engagement: 2 (10.5%) conducted a complier-average-causal effect (CACE) analysis (principal stratum strategy) and 17 (89.5%) used a less-preferred per-protocol (PP) population excluding individuals failing to meet engagement criteria (estimand strategies unclear). Meta-analysis for PP estimates, when accounting for user engagement, changed the standardised effect to -0.18 95% CI (-0.32, -0.04) from − 0.14 95% CI (-0.24, -0.03) and sample sizes reduced by 33% decreasing precision, whereas meta-analysis for CACE estimates were − 0.19 95% CI (-0.42, 0.03) from − 0.16 95% CI (-0.38, 0.06) with no sample size decrease and less impact on precision. Discussion: Many articles report user engagement metrics but few assessed the impact on the intervention effect missing opportunities to answer important patient centred questions for how well DMHIs work for engaged users. Defining engagement in this area is complex, more research is needed to obtain ways to categorise this into groups. However, the majority that considered engagement in analysis used approaches most likely to induce bias. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Methodological considerations in cross-sectional studies validating the International Classification of Functioning, Disability and Health (ICF) Core-Sets: a systematic review.
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Rojas, M., Guilera, G., Arias-Patiño, E., Barrios, M., and Gómez-Benito, J.
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CINAHL database , *CROSS-sectional method , *SAMPLE size (Statistics) , *DATABASE searching , *INTERNET searching - Abstract
AbstractPurposeMaterials and methodsResultsConclusions\nIMPLICATIONS FOR REHABILITATIONTo describe and analyze the methodological characteristics and quality of cross-sectional studies that have validated an ICF-CS.A systematic review was conducted to identify empirical studies published in English that validated any ICF-CS using a cross-sectional design. Databases searched included Web of Science, Scopus, CINAHL, PubMed, Embase, and PsycINFO. The search was conducted in November 2022 with an update in October 2023. Two independent reviewers coded studies that met the inclusion criteria and assessed their methodological quality and risk of bias using the AXIS tool. Synthesis was performed by calculating frequencies and percentages.87 articles validating 24 ICF-CSs were analyzed. Most articles showed strengths in consistency between study objectives and the outcome variables measured. However, a large majority did not report sample size calculation (up to 94.2% in Delphi studies), and few validation studies were conducted in the WHO regions of Africa and the Eastern Mediterranean.The quality of cross-sectional studies validating ICF-CSs was satisfactory, although several articles did not describe aspects such as sample size calculation. Validity evidence for ICF-CS studies could be improved by conducting more multicenter studies, replicating ICF-CS validation studies in different WHO regions, and through synthesis of existing research.Cross-sectional validation studies of ICF-CSs have satisfactory quality, supporting the use of the CSs in clinical rehabilitation settings similar to those evaluated here.Additional validation studies are required for ICF-CSs that have not yet been validated or for which validity evidence is limited.The methodological findings of this review constitute a roadmap that could guide the development and improve the quality of future ICF-CS validation studies.Knowing which ICF-CSs are validated through cross-sectional designs is useful for planning and designing interventions and instrument development.Cross-sectional validation studies of ICF-CSs have satisfactory quality, supporting the use of the CSs in clinical rehabilitation settings similar to those evaluated here.Additional validation studies are required for ICF-CSs that have not yet been validated or for which validity evidence is limited.The methodological findings of this review constitute a roadmap that could guide the development and improve the quality of future ICF-CS validation studies.Knowing which ICF-CSs are validated through cross-sectional designs is useful for planning and designing interventions and instrument development. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Peripheral immune profile and neutrophil‐to‐lymphocyte ratio in progressive supranuclear palsy: Case–control study and meta‐analysis.
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Muñoz‐Delgado, Laura, Luque‐Ambrosiani, Antonio, Zamora, Belén Benítez, Macías‐García, Daniel, Jesús, Silvia, Adarmes‐Gómez, Astrid, Ojeda‐Lepe, Elena, Carrillo, Fátima, and Mir, Pablo
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LYMPHOCYTE count , *PARKINSON'S disease , *LEUCOCYTES , *INFLAMMATION , *PROGRESSIVE supranuclear palsy , *DATABASE searching - Abstract
Background and purpose Methods Results Conclusions Peripheral inflammation is probably involved in the pathogenesis of progressive supranuclear palsy (PSP) and it may be a common feature with Parkinson's disease (PD). The peripheral immune profile in PSP remains unclear, as well as whether the inflammatory pathways differ from those in PD. The neutrophil‐to‐lymphocyte ratio (NLR) has been proven to be a well‐established biomarker of systemic inflammation. This study aimed to evaluate the peripheral immune profile in PSP compared with PD.A cross‐sectional study was conducted including patients with PSP and PD and healthy controls (HCs). Leukocyte subpopulations and the NLR were measured in peripheral blood. Multivariate linear regression and post hoc tests were applied. Electronic databases were searched in November 2023 to perform meta‐analyses to clarify the peripheral immune profile in PSP.Our cohort included 121 patients with PSP, 127 patients with PD and 266 HCs. The NLR was higher in PSP and PD compared with HCs. PSP had a higher neutrophil count compared with HCs. Whilst a lower lymphocyte count was found in PD compared with HCs, the lymphocyte count did not differ between PSP and HCs. The meta‐analyses supported this immune profile.PSP and PD show an increased peripheral inflammation and a higher NLR compared with HCs. Different pathogenic inflammatory mechanisms are probably involved in PSP and PD, since in PSP this altered peripheral immune profile is mainly driven by neutrophils. Understanding the neutrophils' role in PSP may allow for the development of targeted therapies. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Nonalcoholic or metabolic-associated fatty liver disease and colorectal polyps: evidence from meta-analysis and two-sample Mendelian randomization.
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Dong Zhai, Sumei Xu, Haoge Liu, and Xiaojuan Tong
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NON-alcoholic fatty liver disease ,COLON polyps ,ADENOMATOUS polyps ,CHRONIC diseases ,DATABASE searching ,SUBGROUP analysis (Experimental design) - Abstract
Introduction: Nonalcoholic or metabolism-associated fatty liver disease (NAFLD or MAFLD) and colorectal polyps are chronic conditions strongly linked to lifestyle factors. However, the precise causal link between NAFLD or MAFLD and the development of colorectal polyps is not yet fully understood. This study aimed to evaluate the association between NAFLD or MAFLD and the risk of colorectal polyps based on a meta-analysis and two-sample Mendelian randomization (MR) analyses. Methods: PubMed, Embase, Cochrane Library databases were searched for eligible studies to be included in the meta-analysis. We conducted a thorough search of the PubMed, Embase, and Cochrane Library databases to identify eligible studies prior to 22 March 2024. Subgroup analyses were performed based on sex, age, and geographical region. Causality between NAFLD/MAFLD and colorectal polyps was explored by using two-sample Mendelian randomization (MR) analyses. Results: Based on an analysis of 17 studies encompassed within thismeta-analysis, a significant correlation was identified between the presence of NAFLD/MAFLD and elevated incidence of colorectal polyps (NAFLD: OR = 1.57, 95% CI: 1.43-1.73, I² = 38%, p = 0.06; MAFLD: OR = 1.67, 95% CI: 1.40-2.00, I² = 77%, p = 0.002). However, current evidence does not support a causal relationship between NAFLD/MAFLD and the prevalence of colorectal polyps (OR= 0.9998315, 95% CI: 0.9987566-1.000907, P = 0.7587638). Conclusion: NAFLD/MAFLD demonstrated a significant positive correlation with an elevated risk of developing colorectal polyps. However, the MR analysis suggested that no causal relationship existed between NAFLD/MAFLD and colorectal polyps. Therefore, further research is required to identify the underlying mechanism of causal link between these diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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42. The use of glucocorticoid in severe fever with thrombocytopenia syndrome: a retrospective cohort study.
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Yuzhang Chen, Huan Wang, Fengqin Zhou, and Chunxia Guo
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PROPENSITY score matching ,DEATH rate ,DATABASE searching ,COHORT analysis ,THROMBOCYTOPENIA - Abstract
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is prevalent in East Asia. However, the use of glucocorticoids (GCs) in the treatment of SFTS remains controversial. Methods: In this retrospective cohort study, we collected the data from patients with SFTS at Wuhan Union Hospital to evaluate the effect of GC therapy. Mortality and secondary infections were compared as outcomes. After searching public databases, we also included articles that examined GC use in patients with SFTS for meta-analysis. Results: Patients treated with GC had higher fatality rates (21.1% vs. 11.9%, respectively; P=0.006) and a longer length of stay (10.6 ± 5.1 vs. 9.5 ± 4.2, respectively; P=0.033). In cohorts adjusted using propensity score matching and inverse probability of treatment weighting, no significant differences in fatality rates and length of stay were observed. A meta-analysis of 4243 SFTS patient revealed that those treated with GCs had significantly higher mortality (OR=3.46, 95% CI =2.12-5.64, P<0.00001) and secondary infection rate (OR=1.97, 95% CI=1.45-2.67, P<0.0001). Discussion: GC should be used cautiously when treating SFTS. No significant differences were identified in terms of mortality and secondary infection rates between patients with SFTS treated with or without GC. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Predictors for success and failure in international medical graduates: a systematic review of observational studies.
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Schabort, Inge, Esfahani, Meisam Abdar, Couban, Rachel, Roberts, Nia Wyn, Heneghan, Carl, Arora, Neha, and Ashoorion, Vahid
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WORKFORCE planning ,ODDS ratio ,DATABASE searching ,RESIDENTS (Medicine) ,PHYSICIANS - Abstract
Background: International Medical Graduates (IMG) are an essential part of the international physician workforce, and exploring the predictors of success and failure for IMGs could help inform international and national physician labour workforce selection and planning. The objective of this study was to explore predictors for success for selection of IMGs into high stakes postgraduate training positions and practice and not necessarily for informing IMGs. Methods: We searched 11 databases, including Medline, Embase and LILACS, from inception to February 2022 for studies that explored the predictors of success and failure in IMGs. We reported baseline probability, effect size in relative risk (RR), odds ratio (OR) or hazard ratio (HR) and absolute probability change for success and failure across six groups of outcomes, including success in qualifying exams, or certificate exams, successful matching into residency, retention in practice, disciplinary actions, and outcomes of IMG clinical practice. Results: Twenty-five studies (375,549 participants) reported the association of 93 predictors of success and failure for IMGs. Female sex, English fluency, graduation recency, higher scores in USMLE step 2 and participation in a skill assessment program were associated with success in qualifying exams. Female sex, English fluency, previous internship and results of qualifying exams were associated with success in certification exams. Retention to work in Canada was associated with several factors, including male sex, graduating within the past five years, and completing residency over fellowships. In the UK, IMGs and candidates who attempted PLAB part 1, ≥ 4 times vs. first attempters, and candidates who attempted PLAB part 2, ≥ 3 times vs. first attempters were more likely to be censured in future practice. Patients treated by IMGs had significantly lower mortalities than those treated by US graduates, and patients of IMGs had lower mortalities [OR: 0.82 (95% CI: 0.62, 0.99)] than patients of US citizens who trained abroad. Conclusions: This study informed factors associated with the success and failure of IMGs and is the first systematic review on this topic, which can inform IMG selection and future studies. Systematic review registration: PROSPERO: CRD42021252678. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Contraindications in national guidelines for vaginal breech delivery at term: Comparison, consensus, and controversy.
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Dijk, Merle R., Papatsonis, Christiaan, Ganzevoort, Wessel, Moll, Etelka, Scheele, Fedde, and Velzel, Joost
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DELIVERY (Obstetrics) , *CESAREAN section , *ABDOMINAL surgery , *PATIENT selection , *DATABASE searching , *NEONATAL surgery , *BREECH delivery - Abstract
Introduction Material and Methods Results Conclusions The optimal mode of delivery for vaginal breech presentation remains a clinical dilemma. Planned vaginal delivery offers maternal advantages because it avoids major abdominal surgery and has no consequences for following pregnancies, while elective cesarean delivery proves advantageous for the neonate because adverse outcomes are less frequent. Patient selection for vaginal breech delivery is important based on the individual risk balance. A lack of consensus exists regarding the specific contraindications for vaginal breech delivery, largely due to limited scientific evidence. This systematic review aims to give an overview of contraindications for vaginal breech delivery, as presented in guidelines, analyze relevant literature, and offer evidence‐based recommendations for the contraindications stated in the guidelines.To identify national guidelines PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, NICE, UpToDate, and ClinicalKey were searched using two keywords: “breech presentation” and “vaginal delivery.” We systematically reviewed the literature for existing evidence for contraindications for term vaginal breech delivery. The following databases were searched: PubMed (April 2024), the Cochrane Central Register of Controlled Trials, and EMBASE (1947 to 2024).Our search identified eight guidelines that stated a total of 11 contraindications for vaginal breech delivery. Among these guidelines, agreement was limited, with the sole consensus in all guidelines on the contraindication of footling breech. Our comprehensive literature search yielded 43 articles discussing 14 potential contraindications. We found supportive evidence for 7 of 11 contraindications from the guidelines, with only substantial and satisfactory evidence for two contraindications.The findings of this study underscore the lack of consensus among national guidelines regarding contraindications for term vaginal breech delivery. Furthermore, we found a notable lack of substantial scientific evidence to support these contraindications. In light of these findings, we suggest a reduced list of contraindications in vaginal breech deliveries. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Effectiveness of Psychological Interventions for Incarcerated Individuals with Depression or Posttraumatic Stress Disorder: A Systematic Review.
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Rosenfeld, Barry, Callahan, Perry, Carboni-Jiménez, Andrea, Rice, Danielle B., Nassar, Elsa-Lynn, Boruff, Jill T., Li, Kexin, and Thombs, Brett D.
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INTERPERSONAL psychotherapy , *PSYCHOTHERAPY , *RANDOMIZED controlled trials , *PRISONERS , *DATABASE searching , *POST-traumatic stress disorder - Abstract
AbstractThe effectiveness of psychotherapy for depression and posttraumatic stress disorder (PTSD) has been well-established in community samples but its effectiveness in carceral settings is less clear. The present systematic review thus sought to evaluate the effects of psychological therapies for PTSD and depression in incarcerated samples. We searched five databases from inception through January 2023, for eligible randomized controlled trials (RCTs). Two reviewers independently reviewed the study eligibility, extracted the data, assessed the intervention reporting, and evaluated the risk of bias. Eleven RCTs met inclusion criteria, five addressing treatment of PTSD, and six addressing treatment of depression. Interventions produced mixed findings with respect to symptom reduction relative to active controls, with a significant risk of methodological bias in virtually all studies. Of the interventions studied, interpersonal psychotherapy produced the most encouraging, though clearly still tentative results for the treatment of depression. Results highlight the need for increased methodological rigor and additional research to examine the effectiveness of interventions that have yielded positive results in community samples. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Influence of protocol variables on outcomes of the star excursion balance test group (SEBT, mSEBT, YBT-LQ) in healthy individuals: a systematic review.
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Zając, Bartosz, Olszewski, Maciej, and Mika, Anna
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EQUILIBRIUM testing ,VARIABLE stars ,DYNAMIC balance (Mechanics) ,DATABASE searching ,WARMUP - Abstract
Background: The "SEBT group," which includes the Star Excursion Balance Test (SEBT), its modified version (mSEBT), and the Lower Quarter Y-Balance Test (YBT-LQ), is used to assess the limits of stability. Interestingly, the testing protocol allows users a considerable degree of flexibility, which can affect the obtained results. Therefore, the objective of this systematic review was to analyze the impact of different protocol variants within the "SEBT group" on outcomes. Methods: Data were acquired by searching 4 databases (MEDLINE, ScienceDirect, Wiley, Springer Link) focusing on studies published in English in peer-reviewed journals, empirical in nature, conducted on healthy individuals, and examining the effects of various protocol variants on test outcomes. Study quality was assessed with the NHLBI quality assessment tool for pre-post studies with no control group. Results: The calculation method based on the maximum repetition yields statistically significantly higher results compared to other calculation methods. Allowing unrestricted arm movements during the test results in statistically significantly higher scores compared to the procedure that restricts arm movements. The impact of a warm-up, wearing footwear during testing, and using a dedicated kit remains ambiguous. To obtain reliable results, 4-6 familiarization trials are necessary, though fewer may suffice for athletes experienced in performing the test. Conclusion: This systematic review highlights the significant impact of the calculation method and arm movement restrictions on the outcomes of the "SEBT group." The effects of wearing footwear during testing, warm-up, and using a dedicated test kit remain unclear. The required number of familiarization repetitions may varies depending on biological maturity level of the person being tested. Future research should develop a warm-up protocol tailored to the needs of the "SEBT group," and investigate the impact of heel elevation during testing on outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Main chemical constituents and mechanism of anti‐tumor action of Solanum nigrum L.
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Zhao, Zhen‐duo, Hu, Cheng, Li, Ling, Zhang, Jia‐qi, and Zhang, Li‐chao
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SOLANUM nigrum , *PLANT extracts , *DATABASE searching , *BIOACTIVE compounds , *SAPONINS - Abstract
Objective: Solanum nigrum L. (SNL) is a natural drugwith diverse bioactive components and multi‐targeted anti‐tumor effects, gaining increasing attention in clinical application. Method and Results: This paper reviews the studies on SNL by searching academic databases (Google Scholar, PubMed, Science Direct,and Web of Science, among others), analyzing its chemical compositions (alkaloids, saponins, polysaccharides, and polyphenols, among others), andbriefly describes the anti‐tumor mechanisms of the main components. Discussion: This paper discusses the shortcomings of the current research on SNL and proposes corresponding solutions, providing theoretical support for further research on its biological functions and clinical efficacy. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Sure Steps: Key Strategies for Protecting Basketball Players from Injuries—A Systematic Review.
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Antoranz, Yoel, Sáez de Villarreal, Eduardo, del Campo Vecino, Juan, and Jiménez-Saiz, Sergio L.
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ANTERIOR cruciate ligament injuries , *ANKLE injuries , *BASKETBALL players , *PREVENTION of injury , *DATABASE searching - Abstract
Background: Basketball is a high-intensity sport, which includes actions such as jumping, changes of direction, accelerations, and decelerations, which generates fatigue situations that may increase the risk of injury. Specifically, the joints at greatest risk are the ankle and knee, with ankle sprains and anterior cruciate ligament (ACL) tears being the most prevalent injuries. There are several strategies aimed at reducing the incidence, based on training methods or other prophylactic measures. Therefore, the purpose of the study is to perform a systematic review of the different injury prevention strategies in competitive-level basketball players with respect to general injuries, ankle sprains, and ACL injuries. Methods: For this purpose, the PRISMA methodology was applied, performing a search in three databases (PubMed, SPORTDiscus, and Cochrane) between 25 September 2023 and 8 October 2023. Results: A total of 964 articles were identified, out of which 283 were duplicates and 644 were discarded. Out of the remaining 37, 23 were excluded because they did not meet the inclusion criteria; therefore, 14 articles were finally included. With respect to general injuries, 8 out of 14 studies reviewed them. Concerning ankle sprains, 7 studies specifically analyzed them. Finally, 3 studies focused on ACL injuries. Conclusions: Training programs that combine different contents, known as neuromuscular training, including strength work, stabilization or core, mobility, and agility are the most effective for both general injuries and ACL injuries. For ankle sprains, the most effective measures are training programs based on analytical ankle stability exercises and the use of ankle braces. Adherence to prevention programs is essential, so they can be included as part of the warm-up. Other strategies such as training load control, functional assessment, or rule modification are not used in the included articles, so their effectiveness as prophylactic methods could not be justified. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Efficacy and Safety of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis: A Systematic Review and Meta-Analysis.
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Yang, Teng-Kai, Wang, Yu-Jen, Li, Hsing-Ju, Yu, Ya-Fang, Huang, Kai-Wen, and Cheng, Jason Chia-Hsien
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HYPERBARIC oxygenation , *RANDOM effects model , *CHRONICALLY ill , *RADIOTHERAPY , *DATABASE searching - Abstract
Background: Radiation-induced hemorrhagic cystitis (RHC) is a chronic inflammatory disease in patients undergoing radiation therapy that causes a cluster of symptoms which may have a latent period of months to years. The current non-invasive treatments include drug treatment and hyperbaric oxygen therapy (HBOT), which has been widely applied for RHC so far but with limited evidence. Thus, we conducted a systematic review and meta-analysis to clarify the effects and safety of HBOT for RHC. Methods: A systematic review and meta-analysis were utilized, searching in the databases of Embase, Pubmed, and Web of Science. The primary endpoint of the present study was complete remission of hematuria. The meta-analysis was conducted using a random effects model, and a pooled odds ratio with 95% CI was calculated. Results: A total of 317 studies were searched and fourteen articles with 556 patients were collected. The results showed that a total of 500 patients (89.9%) had symptom improvement, and the pooled results demonstrated that 55% of patients with HBOT had complete remission of hematuria (95% CI 51–59%). Conclusions: A significant improvement of symptoms when treated with HBOT was shown in this meta-analysis for patients with RHC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
50. Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis.
- Author
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Buzatu, Roxana, Luca, Magda Mihaela, and Bumbu, Bogdan Andrei
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DIETARY supplements , *PERIODONTAL disease , *ORAL health , *DATABASE searching , *ODDS ratio , *VITAMIN C - Abstract
Recent research has highlighted potential benefits of vitamin C in managing periodontal diseases, yet systematic reviews to consolidate these findings are scarce. This study aims to evaluate the effectiveness of vitamin C supplementation in preventing and treating periodontal diseases and elucidate the biological mechanisms underlying these effects. We conducted a systematic review following PRISMA guidelines, searching three databases up to 13 April 2024, for studies from 2010 onward. Our selection criteria aimed to capture a wide range of studies regarding vitamin C's impact on periodontal health. After rigorous screening, 16 studies were included in the final analysis. Meta-analysis techniques were employed to synthesize data and evaluate the association between vitamin C intake and periodontal disease outcomes. The meta-analysis included 17,853 participants from studies with diverse geographical and demographic settings. Notable findings indicated that higher vitamin C intake was associated with a reduction in periodontal disease risk, with a pooled odds ratio (OR) of 1.52 (95% CI: 1.49–1.55). The individual studies reported ORs ranging from 0.62 (95% CI: 0.38–0.94) indicating significant protective effects, to 1.66 (95% CI: 1.04–2.64), suggesting increased risks associated with inadequate vitamin C levels. The heterogeneity among the studies was high (I2 = 95.46%), reflecting variability in study design and population characteristics. This systematic review confirms that vitamin C supplementation has a beneficial effect on periodontal health. The significant variability across studies suggests that individual dietary needs and baseline vitamin C levels might influence the effectiveness of supplementation. These findings underscore the importance of personalized nutritional guidance as part of comprehensive periodontal care. Future research should focus on longitudinal studies to better understand the causal relationships and potential confounding factors affecting the link between vitamin C intake and periodontal health. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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