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Your search keyword '"D. W. Swinkels"' showing total 4 results
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4 results on '"D. W. Swinkels"'

1. Experimental acute kidney injury

Author

A. Kuma, S. Yamada, T. Miyamoto, R. Serino, M. Tamura, Y. Otsuji, K. Kohno, W. Y. Cho, M.-G. Kim, S.-K. Jo, H. K. Kim, J. C. Jado, B. Humanes, V. Lopez-Parra, S. Camano, J. M. Lara, E. Cercenado, A. Tejedor, A. Lazaro, M. Jansen, G. Castellano, A. Stasi, A. Intini, M. Gigante, A. M. Di Palma, C. Divella, G. S. Netti, C. Prattichizzo, P. Pontrelli, A. Crovace, F. Staffieri, E. Fiaccadori, N. Brienza, G. Grandaliano, G. B. Pertosa, L. Gesualdo, K. Xanthopoulou, I. Tsouchnikas, G. Ouzounidis, G. Kokaraki, R. Lagoudaki, C. Simeonidou, G. Karkavelas, E. Spandou, D. Tsakiris, K. Kallaras, R. Schneider, M. Meusel, B. B. Betz, C. Held, K. Moller-Ehrlich, M. Buttner-Herold, C. Wanner, G. Michael, C. Sauvant, A. Hosszu, Z. Antal, J. Hodrea, S. Koszegi, N. F. Banki, L. Wagner, L. Lenart, A. Vannay, A. J. Szabo, A. Fekete, A. Michael, T. Faga, M. Navarra, M. Andreucci, S. Lemoine, B. Pillot, M. Rabeyrin, A. Varennes, M. Ovize, L. Juillard, L. Gomes Santana, W. Silva Almeida, N. Schor, M. Watanabe, C. D. Fonseca, E. A. Pessoa, M. H. Mendonca, S. M. Fernandes, F. T. Borges, M. F. Vattimo, C. P. C. Ow, F. Tassone, M. P. Koeners, S. C. Malpas, R. G. Evans, C. Alfarano, M.-A. Guardia, P. Lluel, S. Palea, G.-H. Young, V.-C. Wu, D. E. Choi, J. Y. Jeong, Y. K. Chang, S. Chung, K. R. Na, S. S. Kim, K. W. Lee, Y. Yang, L. Zhang, P. Fu, Y. Zhao, X. Zhang, I. Jadot, A.-E. Decleves, V. Colombaro, B. Martin, V. Voisin, I. Habsch, E. Deprez, J. Nortier, N. Caron, T. Iwakura, T. Fujikura, N. Ohashi, H. Yasuda, Y. Fujigaki, C. F. Vasco, M. D. F. F. Vattimo, J. Draibe, Y. Y ld r m, O. Aba, Z. Y lmaz, A. K. Kadiroglu, M. E. Y lmaz, M. Gul, A. Ketani, L. Colpan, L. B. d. M. Neiva, J. Suller Garcia, A. S. d. Oliveira, M. A. Naves, R. P. L. Van Swelm, J. F. M. Wetzels, V. G. M. Verweij, C. M. M. Laarakkers, J. C. L. M. Pertijs, D. W. Swinkels, R. Masereeuw, J. Sereno, P. Rodrigues-Santos, H. Vala, P. Rocha-Pereira, J. Fernandes, A. Santos-Silva, F. Teixeira, F. Reis, A. Altuntas, H. R. Yilmaz, E. Uz, M. Demir, A. Gokcimen, D. S. Bayram, O. Aksu, M. T. Sezer, K. H. Yang, Y. J. Jung, D. Kim, A. S. Lee, S. Lee, K. P. Kang, S. K. Park, W. Kim, N. A. Junglee, C. R. Searell, M. M. Jibani, J. H. Macdonald, C.-C. Wu, C.-C. Chen, K.-C. Lu, Y.-F. Lin, G. R. Estrela, F. Wasinski, R. Pereira, D. Malheiros, N. O. S. Camara, R. C. Araujo, M. F. Ramos, C. d. S. Passos, C. V. Razvickas, F. Borges, M. Ormanji, E. Plotnikov, M. Morosanova, I. Pevzner, L. Zorova, V. Manskikh, M. Skulachev, V. Skulachev, D. Zorov, C. F. Pinto, M. Vattimo, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National de la Recherche Agronomique (INRA)

Subjects
0303 health sciences, Transplantation, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Acute kidney injury, Urology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Nephrology, Medicine, business, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract

International audience

Published
2014
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2. Single spin density gradient ultracentrifugation method for the detection and isolation of light and heavy low density lipoprotein subfractions

Author

D W Swinkels, H L Hak-Lemmers, and P N Demacker

Subjects
Biochemistry, QD415-436
Abstract

A single spin density gradient ultracentrifugation method in a swinging bucket rotor has been applied for the detection and isolation of low density lipoprotein (LDL) subfractions. The visualization of the LDL heterogeneity was facilitated by prestaining the serum with Coomassie Brilliant Blue R prior to density gradient ultracentrifugation for 19.5 hr. A total of 13 human serum pools was analyzed. In each pool, two LDL subfractions, a lighter LDL1 subfraction, occasionally showing a subdivision into two bands, LDL1A and LDL1B, and a heavier LDL2 could be clearly distinguished by the banding pattern in the density gradient. Physicochemical characteristics of the isolated LDL subfractions were determined. The simple method for detection and isolation of these subfractions presented here may facilitate future studies on LDL heterogeneity.

Published
1987
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3. Increased total cell-free DNA in the serum of pregnant women carrying a fetus affected by trisomy 21.

Author

Kevin Spencer, J. B. de Kok, and D. W. Swinkels

Abstract

Analysis of the levels of cell-free fetal and total DNA in serum of women carrying a male fetus affected by trisomy 21, and comparison of these levels with those in women carrying a normal male fetus. DNA was extracted from archived second-trimester maternal serum samples collected as part of a prenatal screening program. A total of 10 cases with trisomy 21 male fetuses were compared with 10 controls (male fetuses) with samples matched for duration of storage and gestational age. Real-time quantitative PCR of the SRY and albumin genes was used to quantify fetal and total DNA respectively. The median fetal DNA level in the group of 10 pregnancies with trisomy 21 was 31.98 cell-equivalents per mL compared to 34.06 in the control group. The difference was not significant. The median total DNA level in women with a trisomy 21 fetus was significantly higher (P = 0.029) than that in controls (36 152.6 vs 5832.81 cell-equivalents per mL). Although we could not confirm previous studies of an increased amount of fetal DNA in pregnancies affected by trisomy 21, we did find increased levels of total DNA. The possible reasons for these observations are discussed with respect to previous findings. Larger studies are needed to elucidate the true value, if any, of measurement of fetal and total DNA in maternal serum in the context of prenatal screening for chromosomal abnormalities. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2003
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4. Single spin density gradient ultracentrifugation method for the detection and isolation of light and heavy low density lipoprotein subfractions

Author

H. L. M. Hak-Lemmers, Pierre N.M. Demacker, and D W Swinkels

Subjects
Chromatography, Future studies, Density gradient, Ldl subfractions, Cell Biology, QD415-436, Biochemistry, chemistry.chemical_compound, Endocrinology, chemistry, Low-density lipoprotein, Coomassie brilliant blue R, Density gradient ultracentrifugation, lipids (amino acids, peptides, and proteins), Ultracentrifuge, Spin density
Abstract

A single spin density gradient ultracentrifugation method in a swinging bucket rotor has been applied for the detection and isolation of low density lipoprotein (LDL) subfractions. The visualization of the LDL heterogeneity was facilitated by prestaining the serum with Coomassie Brilliant Blue R prior to density gradient ultracentrifugation for 19.5 hr. A total of 13 human serum pools was analyzed. In each pool, two LDL subfractions, a lighter LDL1 subfraction, occasionally showing a subdivision into two bands, LDL1A and LDL1B, and a heavier LDL2 could be clearly distinguished by the banding pattern in the density gradient. Physicochemical characteristics of the isolated LDL subfractions were determined. The simple method for detection and isolation of these subfractions presented here may facilitate future studies on LDL heterogeneity.

Published
1987

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