202 results on '"D'Journo, Xavier-Benoit"'
Search Results
2. Root cause analysis of mortality after esophagectomy for cancer: a multicenter cohort study from the FREGAT database
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Levenson, Guillaume, Coutrot, Maxime, Voron, Thibault, Gronnier, Caroline, Cattan, Pierre, Hobeika, Christian, D’Journo, Xavier Benoît, Bergeat, Damien, Glehen, Olivier, Mathonnet, Muriel, Piessen, Guillaume, and Goéré, Diane
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- 2024
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3. Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer: (DICE) Study
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Chidambaram, Swathikan, Owen, Richard, Sgromo, Bruno, Chmura, Magdalena, Kisiel, Aaron, Evans, Richard, Griffiths, Ewen A, Castoro, Carlo, Gronnier, Caroline, MaoAwyes, M, Gutschow, Christian A, Piessen, Guillaume, Degisors, Sébastien, Alvieri, Rita, Feldman, H, Capovilla, Giovanni, Grimminger, Peter P, Han, Shiwei, Low, Donald E, Moore, Jonathan, Gossage, James, Voeten, Dan, Gisbertz, Suzanne S., Ruurda, Jelle, van Hillegersberg, Richard, D’journo, Xavier Benoit, Phillips, Alexander W, Rosati, Ricardo, Hanna, George B, Maynard, Nick, Hofstetter, W, Ferri, Lorenzo, Berge Henegouwen, Mark I., and Markar, Sheraz R.
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- 2023
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4. The effect of enhanced recovery after minimally invasive esophagectomy: a randomized controlled trial
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Shen, Yaxing, Chen, Xiaosang, Hou, Junyi, Chen, Youwen, Fang, Yong, Xue, Zhanggang, D’Journo, Xavier Benoit, Cerfolio, Robert J., Fernando, Hiran C., Fiorelli, Alfonso, Brunelli, Alessandro, Cang, Jing, Tan, Lijie, and Wang, Hao
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- 2022
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5. IASLC Lung Cancer Staging Project: The New Database to Inform Revisions in the Ninth Edition of the TNM Classification of Lung Cancer
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Asamura, Hisao, Rusch, Valerie, Rami-Porta, Ramón, Araujo, Luiz Henrique, Beer, David, Bertoglio, Pietro, Beyruti, Ricardo, Billè, Andrea, Boubia, Souheil, Brambilla, Elisabeth, Cangir, A.K., Carbone, David, Cilento, Vanessa, Connolly, Casey, Darling, Gail, Detterbeck, Frank, Dibaba, Daniel, D’Journo, Xavier Benoit, Donington, Jessica, Eberhardt, Wilfried, Edwards, John, Erasmus, Jeremy, Fang, Wentao, Fennell, Dean, Fong, Kwun, Galateau-Sallé, Françoise, Gautschi, Oliver, Gill, Ritu R., Giroux, Dorothy, Giuliani, Meredith, Goo, Jin Mo, Hasegawa, Seiki, Hirsch, Fred, Hoffman, Hans, Hofstetter, Wayne, Huang, James, Joubert, Philippe, Kernstine, Kemp, Kerr, Keith, Kim, Young Tae, Kim, Dong Kwan, Kindler, Hedy, Lievens, Yolande, Liu, Hui, Low, Donald E., Lyons, Gustavo, MacMahon, Heber, Mahar, Alyson, Marino, Mirella, Marom, Edith M., Matilla, José-María, van Meerbeeck, Jan, Montuenga, Luis M., Nicholson, Andrew, Nishimura, Katie, Nowak, Anna, Opitz, Isabelle, Okumura, Meinoshin, Osarogiagbon, Raymond U., Pass, Harvey, de Perrot, Marc, Prosch, Helmut, Rice, David, Rimner, Andreas, Rosenthal, Adam, Ruffini, Enrico, Sakai, Shuji, Van Schil, Paul, Singh, Navneet, Suárez, Francisco, Terra, Ricardo M., Travis, William D., Tsao, Ming S., Ugalde, Paula, Watanabe, Shun-ichi, Wistuba, Ignacio, Wynes, Murry, Yatabe, Yasushi, Nishimura, Katherine K., Giroux, Dorothy J., Chansky, Kari, and Hoering, Antje
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- 2023
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6. Does baseline quality of life predict the occurrence of complications in resectable esophageal cancer?
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Sheng, Wei Gilis, Assogba, Emerline, Billa, Oumar, Meunier, Bernard, Gagnière, Johan, Collet, Denis, D'Journo, Xavier Benoît, Brigand, Cécile, Piessen, Guillaume, and Dabakuyo-Yonli, Tienhan Sandrine
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- 2022
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7. Effect of early hyperoxemia on the outcome in servere blunt chest trauma: A propensity score-based analysis of a single-center retrospective cohort
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Duclos, Gary, Rivory, Adrien, Rességuier, Noémie, Hammad, Emmanuelle, Vigne, Coralie, Meresse, Zoé, Pastène, Bruno, D'journo, Xavier-Benoit, Jaber, Samir, Zieleskiewicz, Laurent, and Leone, Marc
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- 2021
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8. The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non–Small Cell Lung Cancer
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Asamura, Hisao, Rusch, Valerie, Rami-Porta, Ramón, Araujo, Luiz Henrique, Beer, David, Bertoglio, Pietro, Beyruti, Ricardo, Bille, Andrea, Bolejack, Vanessa, Boubia, Souheil, Brambilla, Elisabeth, Brierley, James D., Cangir, A.K., Carbone, David, Chansky, Kari, Crowley, John, Darling, Gail, Detterbeck, Frank, D’Journo, Xavier Benoit, Donnington, Jessica, Eberhardt, Wilfried, Edwards, John, Erasmus, Jeremy, Falkson, Conrad, Fang, Wentao, Fennell, Dean, Fong, Kwun, Galateau-Salle, Françoise, Gautschi, Oliver, Gill, Ritu, Giroux, Dorothy, Giuliani, Meredith, Goo, Jin Mo, Hasegawa, Seiki, Hirsch, Fred, Hoffman, Hans, Hofstetter, Wayne, Huang, James, Joubert, Philippe, Kernstine, Kemp, Kerr, Keith, Kim, Young Tae, Kim, Hong Kwan, Kindler, Hedy, Lievens, Yolande, Liu, Hui, Low, Donald E., Lyons, Gustavo, MacMahon, Heber, Marino, Mirella, Marom, Edith, Matilla, José-María, van Meerbeeck, Jan, Montuenga, Luis M., Nicholson, Andrew, Nishimura, Katie, Nowak, Anna, Opitz, Isabelle, Okumura, Meinoshin, Osarogiagbon, Raymond U., Pass, Harvey, de Perrot, Marc, Prosch, Helmut, Rice, David, Rimner, Andreas, Ruffini, Enrico, Sakai, Shuji, Van Schil, Paul, Singh, Navneet, Stoll-D’Astice, Amy, Su´rez, Francisco, Terra, Ricardo M., Travis, William D., Tsao, Ming S., Ugalde, Paula, Waller, David, Watanabe, Shun-ichi, Wiens, Jacinta, Wistuba, Ignacio, Yatabe, Yasushi, Jiang, Liyan, Kubota, Kaoru, Turna, Akif, Weksler, Benny, Tzukazan, Maria Teresa, Tammemägi, Martin, Powell, Charles, Naidich, David, Liu, Hongxu, Armato, Samuel, Brunelli, Alex, Cardillo, Giuseppe, David, Elizabeth, Fournier, Brigitte, Krasnik, Mark, Kubota, Kauro, Labbe, Catherine, Lim, Eric, Putora, Paul Martin, Rocco, Gaetano, Filosso, Pier Luigi, Kondo, Kazuya, Kim, Dong Kwan, Giaccone, Giuseppe, Lucchi, Marco, Infante, Maurizio, Rice, Thomas, Ferguson, Mark, Adsusmilli, Prasad, Travis, William, Suárez, Francisco, Kubota, Kaura, Shun-ichi, Watanabe, Hisao Asamura, Nicholson, Andrew G., Ramón, Rami-Porta, Edith Marom, Tsao, Ming, Shun-ichi, Watanabe, Ming Tsao, Guiliani, Meredith, Brierley, James, Terra, Ricardo, Osarogiagbon, Ray, Montuenga, Luis, Wang, Hongwei, Nakajima, Jun, Galateau, Françoise, Ostrowski, Marcin, Goo, Jim Mo, Travis, Bill, Matilla, Jose Maria, St. Pierre, Carolle, Tzukazan, Ma Teresa, Girard, Nicholas, Rimmer, Andreas, Galateau, Francoise, Adusumilli, Prasad, D’Journo, Xavier, Low, Donald, Rosenthal, Adam, Edwards, John G., Donington, Jessica, Galateau-Sallé, Françoise, Hoffmann, Hans, Marom, Edith M., Tsao, Ming-Sound, Giroux, Dorothy J., Shemanski, Lynn, and Krasnik, Marc
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- 2020
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9. Adenocarcinoma of the oesophagogastric junction Siewert II: An oesophageal cancer better cured with total gastrectomy
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Arnaud, Jean Pierre, Balon, Jean Michel, Bonnetain, Frank, Borie, Frederic, Brachet, Dorothée, Brigand, Cécile, Carrere, Nicolas, D'Journo, Xavier Benoit, Dechelotte, Pierre, Delpero, Jean Robert, Dhari, Abdenaceur, Fabre, Sylvain, Fernandez, Manuel, Flamein, Renaud, Gillet, Brigitte, Glaise, Aude, Glehen, Olivier, Goéré, Diane, Guilbert, Marie, Guiramand, Jérôme, Hebbar, Mohamed, Huten, Noël, Leteurtre, Emmanuelle, Kraft, Kevin, Louis, Damien, Mabrut, Jean Yves, Mathieu, Benjamin, Michalak, Sophie, Michot, Francis, Millat, Bertrand, Lefevre, Jeremie H., Peschaud, Fédérique, Pezet, Denis, Pichot-Delahaye, Virginie, Pocard, Marc, Poisson, Ariane, Prudhomme, Michel, Regimbeau, Jean Marc, Thiébot, Timothée, Thomas, Pascal- Alexandre, Tsilividis, Basile, Vandois, Florence, Voron, Thibault, Gronnier, Caroline, Pasquer, Arnaud, Thereaux, Jeremie, Gagniere, Johan, Lebreton, Gil, Meunier, Bernard, Collet, Denis, Piessen, Guillaume, and Paye, François
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- 2019
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10. Management of paraesophageal hiatus hernia
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Gerdes, Stephan, Schoppmann, Sebastian F, Bonavina, Luigi, Boyle, Nicholas, Mueller-Stich, Beat P, Gutschow, Christian A, Gisbertz, Suzanne Sarah, Kockerling, Ferdinand, Lehmann, Thorsten G, Lorenz, Dietmar, Granderath, Frank Alexander, Rosati, Riccardo, Wullstein, Christoph, Lundell, Lars, Cheong, Edward, Nafteux, Philippe, Olmi, Stefano, Monig, Stefan, Biebl, Matthias, Leers, Jessica, Zehetner, Joerg, Kristo, Ivan, Berrisford, Richard George, Skrobic, Ognjan M, Simic, Aleksandar P, Pera, Manuel, Grimminger, Peter Philipp, Gockel, Ines, Zarras, Konstantinos, Nieuwenhuijs, Vincent Bernard, Gossage, James A, Henegouwen, Mark I van Berge, Stein, Hubert J, Markar, Sheraz R, Hueting, Willem Eduard, Targarona, Eduardo M, Johansson, Jan, Macaulay, Graeme D, Wijnhoven, Bas PL, Benedix, Frank, Attwood, Stephen E, Hoelscher, Arnulf Heinrich, Priego, Pablo, Fuchs, Karl-Hermann, Luyer, Misha DP, Griffiths, Ewen A, Sovik, Torgeir Thorson, Theodorou, Dimitrios, Sgromo, Bruno, Salo, Jarmo A, Singhal, Rishi, Thorell, Anders, Zaninotto, Giovanni, Itenc, Marko, D'journo, Xavier Benoit, Fullarton, Grant M, Horbach, Thomas, Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and CCA - Cancer Treatment and quality of life
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REPAIR ,MESH ,Hiatus hernia ,Mesh ,Science & Technology ,Fundoplication ,Surgical technique ,GUIDELINES ,Paraesophageal hernia ,REFLUX ,Surgery ,Delphi survey ,RECURRENCE ,Life Sciences & Biomedicine - Abstract
Aims There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology. Methods We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure and follow-up) of non-revisional, elective pHH among European surgeons with expertise in upper-GI. Responses were graded on a 5-point Likert scale and analyzed using descriptive statistics. Items from the questionnaire were defined as “recommended” or “discouraged” if positive or negative concordance among participants was > 75%. Items with lower concordance levels were labelled “acceptable” (neither recommended nor discouraged). Results Seventy-two surgeons with a median (IQR) experience of 23 (14–30) years from 17 European countries participated (response rate 60%). The annual median (IQR) individual and institutional caseload was 25 (15–36) and 40 (28–60) pHH-surgeries, respectively. After Delphi round 2, “recommended” strategies were defined for preoperative work-up (endoscopy), indication for surgery (typical symptoms and/or chronic anemia), surgical dissection (hernia sac dissection and resection, preservation of the vagal nerves, crural fascia and pleura, resection of retrocardial lipoma) and reconstruction (posterior crurorrhaphy with single stitches, lower esophageal sphincter augmentation (Nissen or Toupet), and postoperative follow-up (contrast radiography). In addition, we identified “discouraged” strategies for preoperative work-up (endosonography), and surgical reconstruction (crurorrhaphy with running sutures, tension-free hiatus repair with mesh only). In contrast, many items from the questionnaire including most details of mesh augmentation (indication, material, shape, placement, and fixation technique) were “acceptable”. Conclusions This multinational European Delphi survey represents the first expert-led process to identify recommended strategies for the management of pHH. Our work may be useful in clinical practice to guide the diagnostic process, increase procedural consistency and standardization, and to foster collaborative research.
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- 2023
11. Mechanical characterisation of human ascending aorta dissection
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Deplano, Valérie, Boufi, Mourad, Gariboldi, Vlad, Loundou, Anderson D., D’Journo, Xavier Benoit, Cautela, Jennifer, Djemli, Amina, and Alimi, Yves S.
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- 2019
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12. Chest trauma: First 48 hours management
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Bouzat, Pierre, Raux, Mathieu, David, Jean Stéphane, Tazarourte, Karim, Galinski, Michel, Desmettre, Thibault, Garrigue, Delphine, Ducros, Laurent, Michelet, Pierre, Freysz, Marc, Savary, Dominique, Rayeh-Pelardy, Fatima, Laplace, Christian, Duponq, Raphaelle, Monnin Bares, Valérie, D’Journo, Xavier Benoît, Boddaert, Guillaume, Boutonnet, Mathieu, Pierre, Sébastien, Léone, Marc, Honnart, Didier, Biais, Mathieu, and Vardon, Fanny
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- 2017
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13. Effectiveness of Surgeon-Performed Paravertebral Block Analgesia for Minimally Invasive Thoracic Surgery: A Randomized Clinical Trial.
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Chenesseau, Josephine, Fourdrain, Alex, Pastene, Bruno, Charvet, Aude, Rivory, Adrien, Baumstarck, Karine, Bouabdallah, Ilies, Trousse, Delphine, Boulate, David, Brioude, Geoffrey, Gust, Lucile, Vasse, Matthieu, Braggio, Cesare, Mora, Pierre, Labarriere, Ambroise, Zieleskiewicz, Laurent, Leone, Marc, Thomas, Pascal Alexandre, and D'Journo, Xavier-Benoit
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- 2023
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14. Health-related Quality of Life Following Hybrid Minimally Invasive Versus Open Esophagectomy for Patients With Esophageal Cancer, Analysis of a Multicenter, Open-label, Randomized Phase III Controlled Trial: The MIRO Trial
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Mariette, Christophe, Markar, Sheraz, Dabakuyo-Yonli, Tienhan Sandrine, Meunier, Bernard, Pezet, Denis, Collet, Denis, D’Journo, Xavier Benoit, Brigand, Cécile, Perniceni, Thierry, Carrere, Nicolas, Mabrut, Jean Yves, Msika, Simon, Peschaud, Frédérique, Prudhomme, Michel, Bonnetain, Franck, and Piessen, Guillaume
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- 2020
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15. Oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate in lung cancer surgery: a randomized clinical trial
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D'Journo, Xavier Benoit, Falcoz, Pierre-Emmanuel, Alifano, Marco, Le Rochais, Jean-Philippe, D'Annoville, Thomas, Massard, Gilbert, and Regnard, Jean Francois
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Microbiota (Symbiotic organisms) -- Research -- Health aspects ,Mortality -- France ,Staphylococcus aureus infections -- Research ,Lung cancer -- Research ,Clinical trials -- Health aspects -- Research ,Surgery -- Research -- Health aspects ,Health care industry - Abstract
Purpose Respiratory complications are the leading causes of morbidity and mortality after lung cancer surgery. We hypothesized that oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate (CHG) would be an effective method to reduce these complications as reported in cardiac surgery. Methods In this multicenter parallel-group randomized double-blind placebo-controlled trial, we enrolled consecutive adults scheduled for anatomical pulmonary resection for lung cancer. Perioperative decontamination consisted in oropharyngeal rinse solution (0.12% CHG) and nasopharyngeal soap (4% CHG) or a placebo. The primary outcome measure was the proportion of patients requiring postoperative invasive and/or noninvasive mechanical ventilation (MV). Secondary outcome measures included occurrence of respiratory and non-respiratory healthcare-associated infections (HAIs) and outcomes within 90 days. Results Between July 2012 and April 2015, 474 patients were randomized. Of them, 24 had their surgical procedure cancelled or withdrew consent. The remaining 450 patients were included in a modified intention-to-treat analysis: 226 were allocated to CHG and 224 to the placebo. Proportions of patients requiring postoperative MV were not significantly different [CHG 14.2%; placebo 15.2%; relative risks (RRs) 0.93; 95% confidence interval (CI) 0.59-1.45; P = 0.76]. Neither of the proportions of patients with respiratory HAIs were different (CHG 13.7%; placebo 12.9%; RRs 1.06; 95% CI 0.66-1.69; P = 0.81). The CHG group had significantly decreased incidence of bacteremia, surgical-site infection and overall Staphylococcus aureus infections. However, there were no significant between-group differences for hospital stay length, change in tracheal microbiota, postoperative antibiotic utilization and outcomes by day 90. Conclusions CHG decontamination decreased neither MV requirements nor respiratory infections after lung cancer surgery. Additionally, CHG did not change tracheal microbiota or postoperative antibiotic utilization. Trial Registration This study is registered on ClinicalTrials.gov, number NCT01613365., Author(s): Xavier Benoit D'Journo [sup.1] [sup.6], Pierre-Emmanuel Falcoz [sup.2], Marco Alifano [sup.3], Jean-Philippe Le Rochais [sup.4], Thomas D'Annoville [sup.5], Gilbert Massard [sup.2], Jean Francois Regnard [sup.3], Philippe Icard [sup.4], Charles [...]
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- 2018
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16. Oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate in lung cancer surgery: a randomized clinical trial
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D’Journo, Xavier Benoit, Falcoz, Pierre-Emmanuel, Alifano, Marco, Le Rochais, Jean-Philippe, D’Annoville, Thomas, Massard, Gilbert, Regnard, Jean Francois, Icard, Philippe, Marty-Ane, Charles, Trousse, Delphine, Doddoli, Christophe, Orsini, Bastien, Edouard, Sophie, Million, Matthieu, Lesavre, Nathalie, Loundou, Anderson, Baumstarck, Karine, Peyron, Florence, Honoré, Stephane, Dizier, Stéphanie, Charvet, Aude, Leone, Marc, Raoult, Didier, Papazian, Laurent, and Thomas, Pascal Alexandre
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- 2018
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17. Risk Prediction Model of 90-Day Mortality after Esophagectomy for Cancer
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D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, O'Neill, J Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Bas, Jobe, Blair, Davies, Andrew, Schneider, Paul M, Pera, Manuel, Nilsson, Magnus, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R, Hofstetter, Wayne, Molena, Daniela, Jimmy Bok-Yan, So, Immanuel, Arul, Parsons, Simon L, Larsen, Michael Hareskov, Dolan, James P, Wood, Stephanie G, Maynard, Nick, Smithers, Mark, Puig, Sonia, Law, Simon, Wong, Ian, Kennedy, Andrew, Kangning, Wang, Reynolds, John V, Pramesh, C S, Ferguson, Mark, Darling, Gail, Schröder, Wolfgang, Bludau, Marc, Underwood, Tim, van Hillegersberg, Richard, Chang, Andrew, Cecconello, Ivan, Ribeiro, Ulysses, de Manzoni, Giovanni, Rosati, Riccardo, Kuppusamy, Madhankumar, Thomas, Pascal Alexandre, Low, Donald E, Weindelmayer, J., Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, O'Neill, J Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Ba, Jobe, Blair, Davies, Andrew, Schneider, Paul M, Pera, Manuel, Nilsson, Magnu, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R, Hofstetter, Wayne, Molena, Daniela, So, Jimmy Bok-Yan, Immanuel, Arul, Parsons, Simon L, Larsen, Michael Hareskov, Dolan, James P, Wood, Stephanie G, Maynard, Nick, Smithers, Mark, Puig, Sonia, Law, Simon, Wong, Ian, Kennedy, Andrew, Kangning, Wang, Reynolds, John V, Pramesh, C S, Ferguson, Mark, Darling, Gail, Schröder, Wolfgang, Bludau, Marc, Underwood, Tim, van Hillegersberg, Richard, Chang, Andrew, Cecconello, Ivan, Ribeiro, Ulysse, de Manzoni, Giovanni, Rosati, Riccardo, Kuppusamy, Madhankumar, Thomas, Pascal Alexandre, and Low, Donald E
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Male ,medicine.medical_specialty ,Time Factors ,Esophageal Neoplasms ,medicine.medical_treatment ,030230 surgery ,Logistic regression ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,SDG 3 - Good Health and Well-being ,Risk Factors ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Original Investigation ,Models, Statistical ,Performance status ,Receiver operating characteristic ,business.industry ,Mortality rate ,Esophageal cancer ,Middle Aged ,medicine.disease ,Prognosis ,Esophagectomy ,030220 oncology & carcinogenesis ,Cohort ,Surgery ,Female ,business ,Body mass index - Abstract
Importance: Ninety-day mortality rates after esophagectomy are an indicator of the quality of surgical oncologic management. Accurate risk prediction based on large data sets may aid patients and surgeons in making informed decisions. Objective: To develop and validate a risk prediction model of death within 90 days after esophagectomy for cancer using the International Esodata Study Group (IESG) database, the largest existing prospective, multicenter cohort reporting standardized postoperative outcomes. Design, Setting, and Participants: In this diagnostic/prognostic study, we performed a retrospective analysis of patients from 39 institutions in 19 countries between January 1, 2015, and December 31, 2019. Patients with esophageal cancer were randomly assigned to development and validation cohorts. A scoring system that predicted death within 90 days based on logistic regression ß coefficients was conducted. A final prognostic score was determined and categorized into homogeneous risk groups that predicted death within 90 days. Calibration and discrimination tests were assessed between cohorts. Exposures: Esophageal resection for cancer of the esophagus and gastroesophageal junction. Main Outcomes and Measures: All-cause postoperative 90-day mortality. Results: A total of 8403 patients (mean [SD] age, 63.6 [9.0] years; 6641 [79.0%] male) were included. The 30-day mortality rate was 2.0% (n = 164), and the 90-day mortality rate was 4.2% (n = 353). Development (n = 4172) and validation (n = 4231) cohorts were randomly assigned. The multiple logistic regression model identified 10 weighted point variables factored into the prognostic score: age, sex, body mass index, performance status, myocardial infarction, connective tissue disease, peripheral vascular disease, liver disease, neoadjuvant treatment, and hospital volume. The prognostic scores were categorized into 5 risk groups: very low risk (score, =1; 90-day mortality, 1.8%), low risk (score, 0; 90-day mortality, 3.0%), medium risk (score, -1 to -2; 90-day mortality, 5.8%), high risk (score, -3 to -4: 90-day mortality, 8.9%), and very high risk (score, =-5; 90-day mortality, 18.2%). The model was supported by nonsignificance in the Hosmer-Lemeshow test. The discrimination (area under the receiver operating characteristic curve) was 0.68 (95% CI, 0.64-0.72) in the development cohort and 0.64 (95% CI, 0.60-0.69) in the validation cohort. Conclusions and Relevance: In this study, on the basis of preoperative variables, the IESG risk prediction model allowed stratification of an individual patient's risk of death within 90 days after esophagectomy. These data suggest that this model can help in the decision-making process when esophageal cancer surgery is being considered and in informed consent.
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- 2021
18. Benchmarking Complications Associated with Esophagectomy
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Low, Donald E., Kuppusamy, Madhan Kumar, Alderson, Derek, Cecconello, Ivan, Chang, Andrew C., Darling, Gail, Davies, Andrew, D’Journo, Xavier Benoit, Gisbertz, Suzanne S., Griffin, S. Michael, Hardwick, Richard, Hoelscher, Arnulf, Hofstetter, Wayne, Jobe, Blair, Kitagawa, Yuko, Law, Simon, Mariette, Christophe, Maynard, Nick, Morse, Christopher R., Nafteux, Philippe, Pera, Manuel, Pramesh, C. S., Puig, Sonia, Reynolds, John V., Schroeder, Wolfgang, Smithers, Mark, and Wijnhoven, B. P. L.
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- 2019
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19. Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancer†
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Decaluwé, Herbert, Petersen, René Horsleben, Brunelli, Alex, Pompili, Cecilia, Seguin-Givelet, Agathe, Gust, Lucile, Aigner, Clemens, Falcoz, Pierre-Emmanuel, Rinieri, Philippe, Augustin, Florian, Sokolow, Youri, Verhagen, Ad, Depypere, Lieven, Papagiannopoulos, Kostas, Gossot, Dominique, D’Journo, Xavier Benoit, Guerrera, Francesco, Baste, Jean-Marc, Schmid, Thomas, Stanzi, Alessia, Van Raemdonck, Dirk, Bardet, Jeremy, Thomas, Pascal-Alexandre, Massard, Gilbert, Fieuws, Steffen, Moons, Johnny, Dooms, Christophe, De Leyn, Paul, and Hansen, Henrik Jessen
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- 2018
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20. Prediction of survival after a lung transplant at 1 year (SALTO cohort) using information available at different key time points.
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Belaroussi, Yaniss, Hustache-Castaing, Romain, Maury, Jean-Michel, Lehot, Laurent, Rodriguez, Arnaud, Demant, Xavier, Rozé, Hadrien, Brioude, Geoffrey, D'Journo, Xavier-Benoit, Drevet, Gabrielle, Tronc, Francois, Mathoulin-Pélissier, Simone, Jougon, Jacques, Thomas, Pascal-Alexandre, and Thumerel, Matthieu
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LUNG transplantation ,RECEIVER operating characteristic curves ,KIDNEY transplantation ,Q fever - Abstract
Open in new tab Download slide OBJECTIVES A lung transplant is the final treatment option for end-stage lung disease. We evaluated the individual risk of 1-year mortality at each stage of the lung transplant process. METHODS This study was a retrospective analysis of patients undergoing bilateral lung transplants between January 2014 and December 2019 in 3 French academic centres. Patients were randomly divided into development and validation cohorts. Three multivariable logistic regression models of 1-year mortality were applied (i) at recipient registration, (ii) the graft allocation and (iii) after the operation. The 1-year mortality was predicted for individual patients assigned to 3 risk groups at time points A to C. RESULTS The study population consisted of 478 patients with a mean (standard deviation) age of 49.0 (14.3) years. The 1-year mortality rate was 23.0%. There were no significant differences in patient characteristics between the development (n = 319) and validation (n = 159) cohorts. The models analysed recipient, donor and intraoperative variables. The discriminatory power (area under the receiver operating characteristic curve) was 0.67 (0.62–0.73), 0.70 (0.63–0.77) and 0.82 (0.77–0.88), respectively, in the development cohort and 0.74 (0.64–0.85), 0.76 (0.66–0.86) and 0.87 (0.79 – 0.95), respectively, in the validation cohort. Survival rates were significantly different among the low- (< 15%), intermediate- (15%–45%) and high-risk (> 45%) groups in both cohorts. CONCLUSIONS Risk prediction models allow estimation of the 1-year mortality risk of individual patients during the lung transplant process. These models may help caregivers identify high-risk patients at times A to C and reduce the risk at subsequent time points. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Perioperative Cetuximab with Cisplatin and 5-Fluorouracil in Esogastric Adenocarcinoma: A Phase II Study.
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Gronnier, Caroline, Mariette, Christophe, Lepage, Come, Monterymard, Carole, Jary, Marine, Ferru, Aurélie, Baconnier, Mathieu, Adhoute, Xavier, Tavan, David, Perrier, Hervé, Guerin-Meyer, Véronique, Lecaille, Cédric, Bonichon-Lamichhane, Nathalie, Pillon, Didier, Cojocarasu, Oana, Egreteau, Joëlle, D'journo, Xavier Benoit, Dahan, Laétitia, Locher, Christophe, and Texereau, Patrick
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THERAPEUTIC use of monoclonal antibodies ,THERAPEUTIC use of antineoplastic agents ,ADENOCARCINOMA ,PERIOPERATIVE care ,DRUG efficacy ,CONFIDENCE intervals ,CANCER chemotherapy ,FLUOROURACIL ,TREATMENT effectiveness ,CISPLATIN ,RESEARCH funding ,COMPUTED tomography ,PROGRESSION-free survival ,ESOPHAGEAL tumors ,PATIENT safety ,OVERALL survival - Abstract
Simple Summary: The treatment of resectable gastric and gastroesophageal junction adenocarcinomas is enhanced by a strategy of perioperative chemotherapy (CT) when compared with surgery alone. But, there is still a need for new approaches to further improve outcomes in patients treated with perioperative CT. Cetuximab, a human–murine chimeric monoclonal antibody binds with a high affinity to the EGFR binding site, and has shown activity against a variety of tumors, including G/GEJ adenocarcinomas. This study aimed to evaluate the efficacy and safety of perioperative cetuximab combined with 5-fluorouracil and cisplatin for the treatment of gastric and esophageal adenocarcinoma. The results of this phase two study showed safety but lack of efficacy regarding objective tumor response and absence of major toxicity. Purpose: While perioperative chemotherapy provides a survival benefit over surgery alone in gastric and gastroesophageal junction (G/GEJ) adenocarcinomas, the results need to be improved. This study aimed to evaluate the efficacy and safety of perioperative cetuximab combined with 5-fluorouracil and cisplatin. Patients and Methods: Patients received six cycles of cetuximab, cisplatin, and simplified LV5FU2 before and after surgery. The primary objective was a combined evaluation of the tumor objective response (TOR), assessed by computed tomography, and the absence of major toxicities resulting in discontinuation of neoadjuvant chemotherapy (NCT) (45% and 90%, respectively). Results: From 2011 to 2013, 65 patients were enrolled. From 64 patients evaluable for the primary endpoint, 19 (29.7%) had a morphological TOR and 61 (95.3%) did not stop NCT prematurely due to major toxicity. Sixty patients (92.3%) underwent resection. Sixteen patients (/56 available, 28.5%) had histological responses (Mandard tumor regression grade ≤3). After a median follow-up of 44.5 months, median disease-free and overall survival were 24.4 [95% CI: 16.4–39.4] and 40.3 months [95% CI: 27.5–NA], respectively. Conclusion: Adding cetuximab to the NCT regimen in operable G/GEJ adenocarcinomas is safe, but did not show enough efficacy in the present study to meet the primary endpoint (NCT01360086). [ABSTRACT FROM AUTHOR]
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- 2023
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22. Long-term outcome of open versus hybrid minimally invasive Ivor Lewis oesophagectomy: a propensity score matched study†
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Rinieri, Philippe, Ouattara, Moussa, Brioude, Geoffrey, Loundou, Anderson, de Lesquen, Henri, Trousse, Delphine, Doddoli, Christophe, Thomas, Pascal Alexandre, and D’Journo, Xavier Benoit
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- 2017
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23. Benignant and malignant epidemiology among surgical resections for suspicious solitary lung cancer without preoperative tissue diagnosis.
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Armand, Elsa, Boulate, David, Fourdrain, Alex, Nguyen, Ngoc-Anh-Thu, Resseguier, Noémie, Brioude, Geoffrey, Trousse, Delphine, Doddoli, Christophe, D'journo, Xavier-Benoit, and Thomas, Pascal-Alexandre
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SURGICAL excision ,LUNG cancer ,EPIDEMIOLOGY ,DATABASES ,LOGISTIC regression analysis - Abstract
Open in new tab Download slide OBJECTIVES The aim of this study was to describe the epidemiology of patients undergoing diagnostic and/or curative surgical pulmonary resections for lung opacities suspected of being localized primary lung cancers without preoperative tissue confirmation. METHODS We performed a single-centre retrospective study of a prospectively implemented institutional database of all patients who underwent pulmonary resection between January 2010 and December 2020. Patients were selected when surgery complied with the Fleischner society guidelines. We performed a multivariable logistic regression to determine the preoperative variables associated with malignancy. RESULTS Among 1392 patients, 213 (15.3%) had a final diagnosis of benignancy. We quantified futile parenchymal resections in 29 (2.1%) patients defined by an anatomical resection of >2 lung segments for benign lesions that did not modified the clinical management. Compared with patients with malignancies, patients with benignancies were younger (57.5 vs 63.9 years, P < 0.001), had lower preoperative risk profile (thoracoscore 0.4 vs 2.1, P < 0.001), had a higher proportion of wedge resection (50.7% vs 12.2%, P < 0.01) and experienced a lower burden of postoperative complication (Clavien–Dindo IV or V, 0.4% vs 5.6%, P < 0.001). Preoperative independent variables associated with malignancy were (adjusted odd ratio [95% confident interval]) age 1.02 [1.00; 1.04], smoking (year-pack) 1.005 (1.00; 1.01), history of cardiovascular disease 2.06 [1.30; 3.30], history of controlled cancer 2.74 [1.30; 6.88] and clinical N involvement 4.20 [1.11; 37.44]. CONCLUSIONS Futile parenchymal lung resection for suspicious opacities without preoperative tissue diagnosis is rare (2.1%) while surgery for benign lesions represented 15.3% and has a satisfactory safety profile with very low postoperative morbi-mortality. [ABSTRACT FROM AUTHOR]
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- 2023
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24. Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process.
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Chidambaram, Swathikan, Patel, Nikhil M, Sounderajah, Viknesh, Alfieri, Rita, Bonavina, Luigi, Cheong, Edward, Cockbain, Andy, D'Journo, Xavier Benoit, Ferri, Lorenzo, Griffiths, Ewen A, Grimminger, Peter, Gronnier, Caroline, Gutschow, Christian, Hedberg, Jakob, Kauppila, Joonas H, Lagarde, Sjoerd, Low, Donald, Nafteux, Philippe, Nieuwenhuijzen, Grard, and Nilsson, Magnus
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CONSENSUS (Social sciences) ,DELPHI method ,CHEST pain ,PROGNOSIS ,ASYMPTOMATIC patients ,ONCOLOGIC surgery ,VOICE disorders ,ENDOSCOPIC ultrasonography - Abstract
Background: There is currently a lack of evidence-based guidelines regarding surveillance for recurrence after esophageal and gastric (OG) cancer surgical resection, and which symptoms should prompt endoscopic or radiological investigations for recurrence. The aim of this study was to develop a core symptom set using a modified Delphi consensus process that should guide clinicians to carry out investigations to look for suspected recurrent OG cancer in previously asymptomatic patients. Methods: A web-based survey of 42 questions was sent to surgeons performing OG cancer resections at high volume centers. The first section evaluated the structure of follow-up and the second, determinants of follow-up. Two rounds of a modified Delphi consensus process and a further consensus workshop were used to determine symptoms warranting further investigations. Symptoms with a 75% consensus agreement as suggestive of recurrent cancer were included in the core symptom set. Results: 27 surgeons completed the questionnaires. A total of 70.3% of centers reported standardized surveillance protocols, whereas 3.7% of surgeons did not undertake any surveillance in asymptomatic patients after OG cancer resection. In asymptomatic patients, 40.1% and 25.9% of centers performed routine imaging and endoscopy, respectively. The core set that reached consensus, consisted of eight symptoms that warranted further investigations included; dysphagia to solid food, dysphagia to liquids, vomiting, abdominal pain, chest pain, regurgitation of foods, unexpected weight loss and progressive hoarseness of voice. Conclusion: There is global variation in monitoring patients after OG cancer resection. Eight symptoms were identified by the consensus process as important in prompting radiological or endoscopic investigation for suspected recurrent malignancy. Further randomized controlled trials are necessary to link surveillance strategies to survival outcomes and evaluate prognostic value. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Molecular Detection of Microorganisms in Distal Airways of Patients Undergoing Lung Cancer Surgery
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D'Journo, Xavier Benoit, Bittar, Fadi, Trousse, Delphine, Gaillat, Francoise, Doddoli, Christophe, Dutau, Herve, Papazian, Laurent, Raoult, Didier, Rolain, Jean Marc, and Thomas, Pascal Alexandre
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- 2012
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26. Extracapsular Lymph Node Involvement Is a Negative Prognostic Factor After Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Cancer
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D'journo, Xavier Benoît, Avaro, Jean Philippe, Michelet, Pierre, Trousse, Delphine, Tasei, Anne Marie, Dahan, Laetitia, Doddoli, Christophe, Guidicelli, Roger, Fuentes, Pierre, Seitz, Jean Francois, and Thomas, Pascal
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- 2009
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27. Delphi Consensus report from the "Prolonged Air Leak: A Survey" study group on prevention and management of postoperative air leaks after minimally invasive anatomical resections.
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Zaraca, Francesco, Brunelli, Alessandro, Pipitone, Marco Damiano, Abdellateef, Amr, Akar, Firas Abu, Augustin, Florian, Batchelor, Tim, Bertani, Alessandro, Crisci, Roberto, D'Amico, Thomas, D'Journo, Xavier Benoit, Droghetti, Andrea, Fang, Wentao, Gonfiotti, Alessandro, Janík, Miroslav, Jiménez, Marcelo, Kirschbaum, Andreas, Kostic, Marko, Lazzaro, Richard, and Lucchi, Marco
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POSTOPERATIVE care ,CLINICAL decision support systems ,CONSENSUS (Social sciences) ,LUNG surgery ,CANCER invasiveness - Abstract
Open in new tab Download slide OBJECTIVES This study reports the results of an international expert consensus process evaluating the assessment of intraoperative air leaks (IAL) and treatment of postoperative prolonged air leaks (PAL) utilizing a Delphi process, with the aim of helping standardization and improving practice. METHODS A panel of 45 questions was developed and submitted to an international working group of experts in minimally invasive lung cancer surgery. Modified Delphi methodology was used to review responses, including 3 rounds of voting. The consensus was defined a priori as >50% agreement among the experts. Clinical practice standards were graded as recommended or highly recommended if 50–74% or >75% of the experts reached an agreement, respectively. RESULTS A total of 32 experts from 18 countries completed the questionnaires in all 3 rounds. Respondents agreed that PAL are defined as >5 days and that current risk models are rarely used. The consensus was reached in 33/45 issues (73.3%). IAL were classified as mild (<100 ml/min; 81%), moderate (100–400 ml/min; 71%) and severe (>400 ml/min; 74%). If mild IAL are detected, 68% do not treat; if moderate, consensus was not; if severe, 90% favoured treatment. CONCLUSIONS This expert consensus working group reached an agreement on the majority of issues regarding the detection and management of IAL and PAL. In the absence of prospective, randomized evidence supporting most of these clinical decisions, this document may serve as a guideline to reduce practice variation. [ABSTRACT FROM AUTHOR]
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- 2022
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28. Reporting of patient safety incidents in minimally invasive thoracic surgery: a national registered thoracic surgeons experience for improvement of patient safety.
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Bottet, Benjamin, Rivera, Caroline, Dahan, Marcel, Falcoz, Pierre-Emmanuel, Jaillard, Sophie, Baste, Jean-Marc, Seguin-Givelet, Agathe, Tour, Richard Bertrand de la, Bellenot, Francois, Rind, Alain, Gossot, Dominique, Thomas, Pascal-Alexandre, and D'Journo, Xavier Benoit
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- 2022
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29. Roux-en- Y Diversion for Intractable Reflux After Esophagectomy
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D'Journo, Xavier Benoit, Martin, Jocelyne, Gaboury, Louis, Ferraro, Pasquale, and Duranceau, André
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- 2008
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30. Ultra-early initiation of postoperative rehabilitation in the post-anaesthesia care unit after major thoracic surgery: case–control study.
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Pastene, Bruno, Labarriere, Ambroise, Lopez, Alexandre, Charvet, Aude, Culver, Aurélien, Fiocchi, David, Cluzel, Armand, Brioude, Geoffrey, Einav, Sharon, Tankel, James, Hamidou, Zeinab, D'Journo, Xavier Benoit, Thomas, Pascal, Leone, Marc, Zieleskiewicz, Laurent, and Association, the GRACE
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THORACIC surgery ,ELECTIVE surgery ,CASE-control method ,REHABILITATION ,TREATMENT programs ,AIRWAY extubation ,ATELECTASIS - Abstract
Background Physiotherapy is a major cornerstone of enhanced rehabilitation after surgery (ERAS) and reduces the development of atelectasis after thoracic surgery. By initiating physiotherapy in the post-anaesthesia care unit (PACU), the aim was to evaluate whether the ultra-early initiation of rehabilitation (in the first hour following tracheal extubation) would improve the outcomes of patients undergoing elective thoracic surgery. Methods A case–control study with a before-and-after design was conducted. From a historical control group, patients were paired at a 3:1 ratio with an intervention group. This group consisted of patients treated with the ultra-early rehabilitation programme after elective thoracic surgery (clear fluids, physiotherapy, and ambulation). The primary outcome was the incidence of postoperative atelectasis and/or pneumonia during the hospital stay. Results After pairing, 675 patients were allocated to the historical control group and 225 patients to the intervention group. A significant decrease in the incidence of postoperative atelectasis and/or pneumonia was found in the latter (11.4 versus 6.7 per cent respectively; P = 0.042) and remained significant on multivariate analysis (OR 0.53, 95 per cent c.i. 0.26 to 0.98; P = 0.045). A subgroup analysis of the intervention group showed that early ambulation during the PACU stay was associated with a further significant decrease in the incidence of postoperative atelectasis and/or pneumonia (2.2 versus 9.5 per cent; P = 0.012). Conclusions Ultra-early rehabilitation in the PACU was associated with a decrease in the incidence of postoperative atelectasis and/or pneumonia after major elective thoracic surgery. [ABSTRACT FROM AUTHOR]
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- 2022
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31. Perioperative Risk Factors for Anastomotic Leakage After Esophagectomy: Influence of Thoracic Epidural Analgesia
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Michelet, Pierre, D'Journo, Xavier-Benoıt, Roch, Antoine, Papazian, Laurent, Ragni, Jacques, Thomas, Pascal, and Auffray, Jean-Pierre
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- 2005
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32. Elongation gastroplasty with transverse fundoplasty: The Jeyasingham repair
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D'Journo, Xavier Benoit, Martin, Jocelyne, Bensaidane, Soufiane, Ferraro, Pasquale, and Duranceau, Andre
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Surgical clinics ,Gastroesophageal reflux ,Hernia ,Health - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2008.11.067 Byline: Xavier Benoit D'Journo, Jocelyne Martin, Soufiane Bensaidane, Pasquale Ferraro, Andre Duranceau Abbreviations: LES, lower esophageal sphincter Abstract: Surgical management of massive hernias and complex gastroesophageal reflux disease requires a tension-free repair with reliable reflux control. The aim of this observation was to evaluate the functional results of a modified Collis-Nissen gastroplasty with a transverse widening fundoplasty. Author Affiliation: Department of Surgery, Universite de Montreal, Division of Thoracic Surgery, Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada Article History: Received 23 July 2008; Revised 7 October 2008; Accepted 2 November 2008 Article Note: (footnote) Supported by La Fondation de France (Paris) and by the Thoracic Surgery Research Foundation of Montreal.
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- 2009
33. Recurrence in complete responders after trimodality therapy in esophageal cancer
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Bouabdallah, Ilies, Thomas, Pascal Alexandre, D'Journo, Xavier Benoit, Benoit D’Journo, Xavier, Departement de chirurgie thoracique et des maladies de l'oesophage [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hôpital Nord [CHU - APHM]-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,[SDV]Life Sciences [q-bio] ,Pathological response ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,030204 cardiovascular system & hematology ,Esophageal cancer ,medicine.disease ,3. Good health ,Editorial Commentary ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,business ,ComputingMilieux_MISCELLANEOUS ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Neoadjuvant chemoradiotherapy - Abstract
Complete pathological response (pCR) remains one of the most important prognostic factors of long-term survival in esophageal cancer (EC) and gastro-esophageal junction (GEJ) after trimodality treatment including neoadjuvant chemoradiotherapy (CRT) followed by surgery.
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- 2019
34. Congenital pulmonary airway malformation and sequestration: Two standpoints for a single condition
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Fievet, Lucile, Natale, Claudia, D'Journo, Xavier-Benoit, Coze, StéPhanie, Dubus, Jean-Christophe, Guys, Jean-Michel, Thomas, Pascal, and De Lagausie, Pascal
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Genetic disorders -- Care and treatment ,Thoracoscopy -- Methods ,Health - Abstract
Byline: Lucile. Fievet, Claudia. Natale, Xavier-Benoit. D'Journo, Stéphanie. Coze, Jean-Christophe. Dubus, Jean-Michel. Guys, Pascal. Thomas, Pascal. De Lagausie In adults, congenital pulmonary malformations are candidates for surgery due to symptoms. [...]
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- 2015
35. Unplanned readmission and survival after video-assisted thoracic surgery and open thoracotomy in patients with non-small-cell lung cancer: a 12-month nationwide cohort study.
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Bouabdallah, Ilies, Pauly, Vanessa, Viprey, Marie, Orleans, Veronica, Fond, Guillaume, Auquier, Pascal, D'Journo, Xavier Benoit, Boyer, Laurent, and Thomas, Pascal Alexandre
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VIDEO-assisted thoracic surgery ,NON-small-cell lung carcinoma ,PATIENT readmissions ,PROPENSITY score matching ,THORACOTOMY - Abstract
Open in new tab Download slide Open in new tab Download slide OBJECTIVES To compare outcomes at 12 months between video-assisted thoracic surgery (VATS) and open thoracotomy (OT) in patients with non-small-cell lung cancer (NSCLC) using real-world evidence. METHODS We did a nationwide propensity-matched cohort study. We included all patients who had a diagnosis of NSCLC and who benefitted from lobectomy between 1 January 2015 and 31 December 2017. We divided this population into 2 groups (VATS and OT) and matched them using propensity scores based on patients' and hospitals' characteristics. Unplanned readmission, mortality, complications, length of stay and hospitalization costs within 12 months of follow-up were compared between the 2 groups. RESULTS A total of 13 027 patients from 180 hospitals were included, split into 6231 VATS (47.8%) and 6796 OT (52.2%). After propensity score matching (5617 patients in each group), VATS was not associated with a lower risk of unplanned readmission compared with OT [20.7% vs 21.9%, hazard ratio 1.03 (0.95–1.12)] during the 12-months follow-up. Unplanned readmissions at 90 days were mainly due to pulmonary complications (particularly pleural effusion and pneumonia) and were associated with higher mortality at 12 months (13.4% vs 2.7%, P < 0.0001). CONCLUSIONS VATS and OT were both associated with high incidence of unplanned readmissions within 12 months, requiring a better identification of prognosticators of unplanned readmissions. Our study highlights the need to improve prevention, early diagnosis and treatment of pulmonary complications in patients with VATS and OT after discharge. These findings call for improving the dissemination of systematic perioperative care pathway including efficient pulmonary physiotherapy and rehabilitation. [ABSTRACT FROM AUTHOR]
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- 2021
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36. Radiology and artificial intelligence: An opportunity for our specialty
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D'Journo, Xavier Benoit, Falcoz, Pierre-Emmanuel, Alifano, Marco, Le Rochais, Jean-Philippe, D'Annoville, Thomas, Massard, Gilbert, Regnard, Jean Francois, Icard, Philippe, Marty-Ane, Charles, Trousse, Delphine, Doddoli, Christophe, Orsini, Bastien, Edouard, Sophie, Million, Matthieu, Lesavre, Nathalie, Loundou, Anderson, Baumstarck, Karine, Peyron, Florence, Honore, Stephane, Dizier, Stephanie, Charvet, Aude, Leone, Marc, Raoult, Didier, Papazian, Laurent, Thomas, Pascal Alexandre, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Paul Brousse, service de neuroradiologie [Paris], Hôpital Sainte-Anne, Service de chirurgie thoracique et cardio-vasculaire, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Université de Montpellier (UM), Microbes évolution phylogénie et infections (MEPHI), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
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medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,[SDV]Life Sciences [q-bio] ,Specialty ,MEDLINE ,General Medicine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Artificial Intelligence ,030220 oncology & carcinogenesis ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,business ,Radiology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2018
37. Health-related Quality of Life Following HybridMinimally Invasive Versus Open Esophagectomy for Patients With Esophageal Cancer, Analysis of a Multicenter, Open-label, Randomized Phase III Controlled Trial: The MIRO Trial.
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Mariette, Christophe, Markar, Sheraz, Dabakuyo-Yonli, Tienhan Sandrine, Meunier, Bernard, Pezet, Denis, Collet, Denis, D'Journo, Xavier Benoit, Brigand, Cécile, Perniceni, Thierry, Carrere, Nicolas, Mabrut, Jean Yves, Msika, Simon, Peschaud, Frédérique, Prudhomme, Michel, Bonnetain, Franck, and Piessen, Guillaume
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Background: Hybrid minimally invasive esophagectomy (HMIE) has been shown to reduce major postoperative complications compared with open esophagectomy (OE) for esophageal cancer. Objectives: The aim of this study was to compare short- and long-term health-related quality of life (HRQOL) following HMIE and OE within a randomized controlled trial. Methods: We performed a multicenter, open-label, randomized controlled trial at 13 study centers between 2009 and 2012. Patients aged 18 to 75 years with resectable cancers of the middle or lower third of the esophagus were randomized to undergo either transthoracic OE or HMIE. Patients were followed-up every 6 months for 3 years postoperatively and global health assessed with EORTC-QLQC30 and esophageal symptoms assessed with EORTC-OES18. Results: The short-term reduction in global HRQOL at 30 days specifically role functioning [-33.33 (HMIE) vs -46.3 (OE); P = 0.0407] and social functioning [-16.88 (HMIE) vs -35.74 (OE); P = 0.0003] was less substantial in the HMIE group. At 2 years, social functioning had improved following HMIE to beyond baseline (+5.37) but remained reduced in the OE group (-8.33) (P = 0.0303). At 2 years, increases in pain were similarly reduced in the HMIE compared with the OE group [+6.94 (HMIE) vs +14.05 (OE); P = 0.018]. Postoperative complications in multivariate analysis were associated with role functioning, pain, and dysphagia. Conclusions: Esophagectomy has substantial effects upon short-term HRQOL. These effects for some specific parameters are, however, reduced with HMIE, with persistent differences up to 2 years, and maybe mediated by a reduction in postoperative complications. [ABSTRACT FROM AUTHOR]
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- 2020
38. Screening and topical decolonization of preoperative nasal Staphylococcus aureus carriers to reduce the incidence of postoperative infections after lung cancer surgery: a propensity matched study.
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Fourdrain, Alex, Bouabdallah, Ilies, Gust, Lucile, Cassir, Nadim, Brioude, Geoffrey, Falcoz, Pierre-Emmanuel, Alifano, Marco, Rochais, Jean-Philippe Le, D'Annoville, Thomas, Trousse, Delphine, Loundou, Anderson, Leone, Marc, Papazian, Laurent, Thomas, Pascal Alexandre, and D'Journo, Xavier Benoit
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- 2020
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39. Extrapleural cervico-manubriotomy and clavicular swing for the management of a mesenchymal tumour of the middle scalenus: an adapted anterior thoracic inlet approach.
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Todesco, Alban, D'Journo, Xavier Benoit, Fabre, Dominique, and Boulate, David
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- 2021
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40. Barrett’s Esophagus in the Esophageal Remnant: A Critical Long-Term Complication of Subtotal Esophagectomy
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D’Journo, Xavier Benoit, Ferraro, Pasquale, Martin, Jocelyne, and Duranceau, André
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- 2009
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41. Video-assisted thoracoscopic surgery versus open lobectomy for primary non-small-cell lung cancer. A propensity-matched analysis of outcome from the European Society of Thoracic Surgeon database
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Falcoz, Pierre-Emmanuel, Puyraveau, Marc, Thomas, Pascal-Alexandre, Decaluwe, Herbert, Hã¼rtgen, Martin, Petersen, René Horsleben, Hansen, Henrik, Brunelli, Alessandro, Van Raemdonck, Dirk, Dahan, Marcel, Rocco, Gaetano, Varela, Gonzalo, Salaty, Michele, Ruffini, Enrico, Filosso, Pierluigi, Scarci, Marco, Bille, Andrea, D'Journo, Xavier Benoit, Szanto, Zalan, Venuta, Federico, Horsleben, Renã©, Schmidt, Thomas, Piwkowski, Cezary, Gossot, Dominique, Siebenga, Jan, CHU Strasbourg, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ), CHU Marseille, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)
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Databases, Factual ,medicine.medical_treatment ,Atelectasis ,030204 cardiovascular system & hematology ,computer.software_genre ,surgery ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Carcinoma, Non-Small-Cell Lung ,middle aged ,Thoracotomy ,humans ,Aged, 80 and over ,medicine.diagnostic_test ,Database ,Thoracic Surgery, Video-Assisted ,Incidence (epidemiology) ,adult ,General Medicine ,3. Good health ,[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,aged ,female ,Anesthesia ,Video-assisted thoracoscopic surgery ,Cardiology and Cardiovascular Medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,lobectomy ,carcinoma non-small-cell lung ,databases factual ,matched-pair analysis ,lung neoplasms ,lung cancer ,video-assisted thoracoscopic surgery ,aged 80 and over ,incidence ,length of stay ,male ,pneumonectomy ,postoperative complications ,propensity score ,treatment outcome ,thoracic surgery video-assisted ,03 medical and health sciences ,McNemar's test ,Thoracoscopy ,medicine ,Lung cancer ,business.industry ,medicine.disease ,Surgery ,030228 respiratory system ,Propensity score matching ,business ,computer - Abstract
22nd European Conference on General Thoracic Surgery, Copenhagen, DENMARK, JUN 15-18, 2014; International audience; Video-assisted thoracoscopic anatomical resections are increasingly used in Europe to manage primary lung cancer. The purpose of this study was to compare the outcome following thoracoscopic versus open lobectomy in case-matched groups of patients from the European Society of Thoracic Surgeon (ESTS) database. All patients having lobectomy as the primary procedure via thoracoscopy [video-assisted thoracoscopic surgery (VATS)-L)] or thoracotomy (TH-L) were identified in the ESTS database (January 2007 to December 2013). A propensity score was constructed using several patients' baseline characteristics. The matching using the propensity score was responsible for the minimization of selection bias. A propensity score-matched analysis was performed to compare the incidence of postoperative major complications (according to the ESTS database definitions) and mortality at hospital discharge between the matched groups. After exclusions, 28 771 patients were identified: 26 050 having thoracotomy and 2721 having thoracoscopy. Propensity score yielded two well-matched groups of 2721 patients. Numeric variables were compared by Student's t-tests and categorical variables were compared by McNemar's tests. Compared with TH-L, VATS-L was associated with a lower incidence of total complications [n = 792 (29.1%) vs 863 (31.7%), P = 0.0357], major cardiopulmonary complications [n = 316 (15.9%) vs 435 (19.6%), P = 0.0094], atelectasis requiring bronchoscopy [n = 65 (2.4%) vs 150 (5.5%), P < 0.0001], initial ventilation > 48 h [n = 18 (0.7%) vs 38 (1.4%), P = 0.0075] and wound infection [n = 6 (0.2%) vs 17 (0.6%), P = 0.0218]. There was no difference in the incidence of postoperative atrial fibrillation between the two groups (P = 0.14). Postoperative hospital stay was 2 days shorter in the VATS-L patients (mean: 7.8 vs 9.8 days; P = 0.0003). In terms of outcome at hospital discharge, there were 27 deaths in the VATS-L group (1%) versus 50 in the TH-L group (1.9%, P = 0.0201). Data from the ESTS database confirmed that lobectomy performed through VATS is associated with a lower incidence of complications compared with thoracotomy.
- Published
- 2016
42. Oesophagectomy within 30 days after noncurative endoscopic resection for oesophageal cancer: are we able to follow this 'golden' interval?
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D'Journo, Xavier Benoit and Fourdrain, Alex
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ENDOSCOPIC surgery , *ESOPHAGECTOMY , *ONCOLOGIC surgery , *MINIMALLY invasive procedures , *ESOPHAGEAL cancer - Abstract
Oesophagectomy within 30 days after noncurative endoscopic resection for oesophageal cancer: are we able to follow this "golden" interval? Keywords: Endoscopic mucosal resection; Oesophageal cancer; Oesophagectomy; Survival EN Endoscopic mucosal resection Oesophageal cancer Oesophagectomy Survival 1 2 2 02/07/23 20230101 NES 230101 Endoscopic mucosal resection (EMR) is considered the first-line treatment for early-stage intramucosal lesion pT1a (m1-3) and carefully selected pT1b (sm1) non-circumferential oesophageal carcinomas [[1]]. The third reason that may extend the interval between EMR and surgery is potential complications related to EMR. [Extracted from the article]
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- 2023
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43. Current management of esophageal cancer
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D’Journo, Xavier Benoit and Thomas, Pascal Alexandre
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Review Article - Abstract
Management of esophageal cancer has evolved since the two last decades. Esophagectomy remains the primary treatment for early stage esophageal cancer although its specific role in superficial cancers is still under debate since the development of endoscopic mucosal treatment. To date, there is strong evidence to consider that locally advanced cancers should be recommended for a multimodal treatment with a neoadjuvant chemotherapy or a combined chemoradiotherapy (CRT) followed by surgery. For locally advanced squamous cell carcinoma or for a part of adenocarcinoma, some centers have proposed treating with definitive CRT to avoid related-mortality of surgery. In case of persistent or recurrent disease, a salvage esophagectomy remains a possible option but this procedure is associated with higher levels of perioperative morbidity and mortality. Despite the debate over what constitutes the best surgical approach (transthoracic versus transhiatal), the current question is if a minimally procedure could reduce the periopertive morbidity and mortality without jeopardizing the oncological results of surgery. Since the last decade, minimally invasive esophagectomy (MIE) or hybrid operations are being done in up to 30% of procedures internationally. There are some consistent data that MIE could decrease the incidence of the respiratory complications and decrease the length of hospital-stay. Nowadays, oncologic outcomes appear equivalent between open and minimally invasive procedures but numerous phase III trials are ongoing.
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- 2014
44. Commentary: Transoral endoscopic repair of Zenker's diverticulum by a thoracic surgical service
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D'Journo, Xavier Benoit, Fourdrain, Alex, and Boulate, David
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- 2022
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45. Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
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Yang, Hong, Liu, Hui, Chen, Yuping, Zhu, Chengchu, Fang, Wentao, Yu, Zhentao, Mao, Weimin, Xiang, Jiaqing, Han, Yongtao, Chen, Zhijian, Yang, Haihua, Wang, Jiaming, Pang, Qingsong, Zheng, Xiao, Yang, Huanjun, Li, Tao, Lordick, Florian, D'Journo, Xavier Benoit, Cerfolio, Robert J., and Korst, Robert J.
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- 2018
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46. Role of Endoscopy in the Management of Boerhaave Syndrome.
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Tellechea, Juan Ignacio, Gonzalez, Jean-Michel, Miranda-García, Pablo, Culetto, Adrian, D'Journo, Xavier Benoit, Thomas, Pascal Alexandre, and Barthet, Marc
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ENDOSCOPY ,BOERHAAVE'S syndrome ,CAUSES of death ,ESOPHAGEAL surgery ,CLINICAL trials ,THERAPEUTICS - Abstract
Boerhaave syndrome (BS) is a spontaneous esophageal perforation which carries high mortality. Surgical treatment is well established, but the development of interventional endoscopy has proposed new therapies. We expose our experience in a Gastrointestinal and Endoscopy Unit. With a retrospective, observational, open-label, single center, consecutive case series. All patients diagnosed with BS who were managed in our center were included. Treated conservatively, endoscopically or surgically, according to their clinical condition and lesion presentation. Fourteen patients were included. Ten were treated with primary surgery. One conservatively. In total, 7/14 patients required an endoscopic treatment. All required metallic stents deployment, 3 cases over-the-scope-clips concomitantly and one case a novel technique an internal drain. 6/7 cases endoscopically treated achieved complete esophageal healing. In conclusion, endoscopy is an useful tool at all stages BS management: difficult diagnosis, primary treatment in selected patients and as salvage when surgery fails. With mortality rates and outcomes comparables to surgery. [ABSTRACT FROM AUTHOR]
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- 2018
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47. Oncogenic osteomalacia related to an intramuscular mesenchymal tumor of the scalene muscles
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Mennetrey, Clément, D’Journo, Xavier Benoît, Burtey, Stéphane, and Taïeb, David
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- 2021
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48. Trimodality therapy with carboplatin/paclitaxel (CP) or FOLFOX (FFX) for esophageal/esogastric junctional cancer (EC/EGJ): Expanded safety and efficacy data from PROTECT.
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Adenis, Antoine, Piessen, Guillaume, Le Sourd, Samuel, Bogart, Emilie, Paumier, Amaury, Vendrely, Veronique, Glehen, Olivier, Dahan, Laetitia, Simmet, Victor, Bergeat, Damien, Samalin, Emmanuelle, Chauvenet, Marion, d'Journo, Xavier Benoit, Hiret, Sandrine, Gronnier, Caroline, Baty, Manon, Pannier, Diane, Veziant, Julie, Le Deley, Marie-Cecile, and Mirabel, Xavier
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- 2023
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49. Rapid Diagnosis of Lung Tumors, a Feasability Study Using Maldi-Tof Mass Spectrometry.
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Brioude, Geoffrey, Brégeon, Fabienne, Trousse, Delphine, Flaudrops, Christophe, Secq, Véronique, De Dominicis, Florence, Chabrières, Eric, D’journo, Xavier-Benoit, Raoult, Didier, and Thomas, Pascal-Alexandre
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LUNG tumors ,MATRIX-assisted laser desorption-ionization ,LUNG biopsy ,LUNG surgery ,SURGICAL excision ,TIME-of-flight mass spectrometry ,DIAGNOSIS - Abstract
Objective: Despite recent advances in imaging and core or endoscopic biopsies, a percentage of patients have a major lung resection without diagnosis. We aimed to assess the feasibility of a rapid tissue preparation/analysis to discriminate cancerous from non-cancerous lung tissue. Methods: Fresh sample preparations were analyzed with the Microflex LT
TM MALDI-TOF analyzer. Each main reference spectra (MSP) was consecutively included in a database. After definitive pathological diagnosis, each MSP was labeled as either cancerous or non-cancerous (normal, inflammatory, infectious nodules). A strategy was constructed based on the number of concordant responses of a mass spectrometry scoring algorithm. A 3-step evaluation included an internal and blind validation of a preliminary database (n = 182 reference spectra from the 100 first patients), followed by validation on a whole cohort database (n = 300 reference spectra from 159 patients). Diagnostic performance indicators were calculated. Results: 127 cancerous and 173 non-cancerous samples (144 peripheral biopsies and 29 inflammatory or infectious lesions) were processed within 30 minutes after biopsy sampling. At the most discriminatory level, the samples were correctly classified with a sensitivity, specificity and global accuracy of 92.1%, 97.1% and 95%, respectively. Conclusions: The feasibility of rapid MALDI-TOF analysis, coupled with a very simple lung preparation procedure, appears promising and should be tested in several surgical settings where rapid on-site evaluation of abnormal tissue is required. In the operating room, it appears promising in case of tumors with an uncertain preoperative diagnosis and should be tested as a complementary approach to frozen-biopsy analysis. [ABSTRACT FROM AUTHOR]- Published
- 2016
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50. Gastric conduit obstruction after oesophagectomy: a comprehensive approach for surgical revision.
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D'Journo, Xavier Benoit, Fourdrain, Alex, and Boulate, David
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- *
ESOPHAGECTOMY - Published
- 2021
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