108 results on '"Curtis, Ffion"'
Search Results
2. Perinatal health outcomes of women from Gypsy, Roma and Traveller communities: A systematic review
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Ekezie, Winifred, Hopwood, Ellen, Czyznikowska, Barbara, Weidman, Sarah, Mackintosh, Nicola, and Curtis, Ffion
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- 2024
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3. The Application of Kirkpatrick’s Evaluation Model in the Assessment of Interprofessional Simulation Activities Involving Pharmacy Students: A Systematic Review
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El Nsouli, Dayana, Nelson, David, Nsouli, Latifa, Curtis, Ffion, Ahmed, Syed Imran, McGonagle, Ian, Kane, Ros, and Ahmadi, Keivan
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- 2023
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4. Characterising the relationship between sleep stages and associated spectral power in diabetes
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Johnson, Jennifer M., Curtis, Ffion, and Durrant, Simon J.
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- 2022
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5. Evaluating a tool to improve engagement and recruitment of under-served groups in trials
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Morris, Lydia, Dumville, Jo, Treweek, Shaun, Miah, Nasima, Curtis, Ffion, and Bower, Peter
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- 2022
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6. The effect of slow-wave sleep and rapid eye-movement sleep interventions on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
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Johnson, Jennifer M., Durrant, Simon J., Law, Graham R., Santiago, João, Scott, Eleanor M., and Curtis, Ffion
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- 2022
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7. Emergency medical service interventions and experiences during pandemics: A scoping review.
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Laparidou, Despina, Curtis, Ffion, Wijegoonewardene, Nimali, Akanuwe, Joseph, Weligamage, Dedunu Dias, Koggalage, Prasanna Dinesh, and Siriwardena, Aloysius Niroshan
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Background: The global impact of COVID-19 has been profound, with efforts to manage and contain the virus placing increased pressure on healthcare systems and Emergency Medical Services (EMS) in particular. There has been no previous review of studies investigating EMS interventions or experiences during pandemics. The aim of this scoping review was to identify and present published quantitative and qualitative evidence of EMS pandemic interventions, and how this translates into practice. Methods: Six electronic databases were searched from inception to July 2022, supplemented with internet searches and forward and backward citation tracking from included studies and review articles. A narrative synthesis of all eligible quantitative studies was performed and structured around the aims, key findings, as well as intervention type and content, where appropriate. Data from the qualitative studies were also synthesised narratively and presented thematically, according to their main aims and key findings. Results: The search strategy identified a total of 22,599 citations and after removing duplicates and excluding citations based on title and abstract, and full text screening, 90 studies were included. The quantitative narrative synthesis included seven overarching themes, describing EMS pandemic preparedness plans and interventions implemented in response to pandemics. The qualitative data synthesis included five themes, detailing the EMS workers' experiences of providing care during pandemics, their needs and their suggestions for best practices moving forward. Conclusions: Despite concerns for their own and their families' safety and the many challenges they are faced with, especially their knowledge, training, lack of appropriate Personal Protective Equipment (PPE) and constant protocol changes, EMS personnel were willing and prepared to report for duty during pandemics. Participants also made recommendations for future outbreak response, which should be taken into consideration in order for EMS to cope with the current pandemic and to better prepare to respond to any future ones. Trial registration: The review protocol was registered with the Open Science Framework (osf.io/2pcy7). [ABSTRACT FROM AUTHOR]
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- 2024
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8. Effects of cognitive behavioural therapy on insomnia in adults with tinnitus: Systematic review and meta-analysis of randomised controlled trials
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Curtis, Ffion, Laparidou, Despina, Bridle, Chris, Law, Graham R., Durrant, Simon, Rodriguez, Alina, Pierzycki, Robert H., and Siriwardena, Aloysius N.
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- 2021
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9. Development of a core outcome set for pharmacist interventions in chronic kidney disease.
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Ardavani, Ashkon, Curtis, Ffion, Highton, Patrick, Khunti, Kamlesh, and Wilkinson, Thomas J
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EVALUATION of medical care ,CHRONIC kidney failure ,PHARMACISTS ,DELPHI method ,PSYCHOSOCIAL factors - Abstract
A protocol for the e-Delphi consensus study [ABSTRACT FROM AUTHOR]
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- 2024
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10. The role of Vitamin D and physical activity in glycaemic homeostasis
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Curtis, Ffion, Thatcher, Rhys, and Davison, Glen
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612.3 - Abstract
In Wales nearly 5% (160,000) of the population have been diagnosed with diabetes, and it is thought that there is another 66,000 undiagnosed cases (Diabetes UK). Vitamin D deficiency is also increasing in prevalence, and there is emerging evidence linking vitamin D deficiency to impaired β-cell function, insulin resistance, and glucose intolerance, all of which are central to the pathogenesis of type 2 diabetes (Song & Manson, 2010). Following NHS and University ethical approval Welsh domiciled participants (n = 116) with varying levels of glucose control attended the Department of Sport and Exercise laboratory three times over a twelve-month period to examine the relationship between vitamin D and glucose homeostasis. Significant associations were observed between 25(OH)D and measures of glycaemia, and a seasonal variation was observed in 25 hydroxyvitamin D (25(OH)D) in this Welsh population (summer 71.3 ± 23.8; winter 42.6 ± 23.8 nmol/l). Participants with normal glucose control (≤ 6 mmol/l) had significantly (U = 884.00, p = 0.03) higher 25(OH)D concentrations than those with abnormal glucose control (≥ 6.1 mmol/l). A randomised control trial failed to find an effect of vitamin D supplementation (2000 IU/day) and a fifteen-week cycling programme on measures of glycaemia and body composition in 36 healthy participants. There was a significant (23%) increase in vitamin D status in participants in the supplementation groups demonstrating the effectiveness of the dose administered. Combined with the body of evidence in this area (Pittas et al., 2007) the findings from this thesis provide some support for the potential role of vitamin D supplementation in the management and prevention of type 2 diabetes.
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- 2015
11. Patient, carer, and staff perceptions of robotics in motor rehabilitation: a systematic review and qualitative meta-synthesis
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Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph, Goher, Khaled, Niroshan Siriwardena, A., and Kucukyilmaz, Ayse
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- 2021
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12. The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: A systematic review and meta-analysis
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Klaus, Kristel, Butler, Kevin, Curtis, Ffion, Bridle, Chris, and Pennington, Kyla
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- 2019
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13. Does home blood pressure monitoring improve blood pressure‐related outcomes in people living with chronic kidney disease? A systematic review.
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Carey, Nathan P., Curtis, Ffion, Eisenbeisz, McKenna L., Akbari, Sadaf, Sambharia, Meenakshi, Jalal, Diana I., and Wilkinson, Thomas J.
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High blood pressure is an important risk factor for cardiovascular disease and disease progression in chronic kidney disease (CKD). Evidence on the effects of home blood pressure monitoring (HBPM) is limited. This review aimed to determine the effect of HBPM on systolic (SBP) and diastolic blood pressure (DBP) in patients with CKD. We searched medical literature databases for eligible studies presenting pre‐ and post‐data for interventions utilizing HBPM. Study quality was assessed using the NHLBI tools for quality assessment. Heterogeneity prohibited a meta‐analysis so estimates of effects were calculated along a sign test to examine the probability of observing the given pattern of positive effect direction. Eighteen studies were included (n = 1187 participants, mean age 56.7 [± 7.7] years). In 15 studies, HBPM was conducted within the context of additional high‐level tailored support. Overall, the quality of n = 7/18 studies was rated as "good"; n = 6/18 were "fair," and n = 5/18 were rated as "poor." Interventions utilizing HBPM had a significant effect on SBP, with 14/16 studies favoring the intervention (88% [95% CI: 62%–98%], P =.002). Favorable effects were also seen on DBP (73% [95% CI: 45%–92%], P =.059). HBPM had a favorable effect on blood pressure goal attainment (86% [95% CI: 42%–100%], P =.062). HBPM in patients with CKD as part of a multicomponent intervention may lead to clinically significant reductions in blood pressure; however, research is needed to support the validity of this claim due to the high heterogeneity across the studies included. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Health and social care experience and research perception of different ethnic minority populations in the East Midlands, United Kingdom (REPRESENT study).
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Ekezie, Winifred, Cassambai, Shabana, Czyznikowska, Barbara, Curtis, Ffion, O'Mahoney, Lauren L., Willis, Andrew, Chudasama, Yogini, Khunti, Kamlesh, and Farooqi, Azhar
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INTERSEX people ,MINORITIES ,RESEARCH evaluation ,SOCIAL determinants of health ,FOCUS groups ,EAST Europeans ,HUMAN research subjects ,PRIORITY (Philosophy) ,RESEARCH methodology ,MOTIVATION (Psychology) ,DISCRIMINATION (Sociology) ,INTERVIEWING ,SOUTH Asians ,SOCIAL stigma ,QUALITATIVE research ,SELF-efficacy ,SOCIOECONOMIC factors ,PSYCHOSOCIAL factors ,CARIBBEAN people ,DESCRIPTIVE statistics ,LGBTQ+ people ,ASEXUAL people ,REFUGEES ,HEALTH ,INFORMATION resources ,COMMUNICATION ,RESEARCH funding ,ETHNIC groups ,HEALTH equity ,THEMATIC analysis ,DATA analysis software ,MINORITIES in medicine ,MEDICAL research ,SOMALIS - Abstract
Introduction: Ethnic minority populations experience significant health and social care disparities; despite experiencing a greater burden of diseases, these groups are underrepresented in health and social care research. Consequently, related research can be less applicable to these population groups. The REPRESENT study aims to explore the health and social care experiences of ethnic minorities and other minoritised populations, their research interests and appropriate research practices. Methods: Focus groups and semistructured interviews were conducted between May and September 2022 with members of a number of ethnic minority communities in England. Data were audio recorded, transcribed and thematically coded using NVivo 12. Rigour was determined through extensive sampling, iterative data collection and analysis. Findings: Fifty‐two ethnic minority members were engaged in group interviews and one‐to‐one interviews. Participants included representatives of the following groups: African Caribbean, Eastern European, Gypsy Travellers, Lesbian, Gay, Bisexual, Transgender, Queer, Intersex and Asexual+, Refugee/Asylum Seekers, Somali and South Asian communities. Interviews were also conducted with ethnic minority healthcare providers and researchers. Three overarching categories were identified: health information, medical service experiences, health and social care concerns and health research. Health and social care services challenges were mostly attributed to discrimination, delayed services, poor cultural relevance and language and cultural barriers. The most influential information sources were local community organisations and word‐of‐mouth. The main health and social care concerns were chronic long‐term health conditions, mental health, maternal health and child development. Recommendations for research involved understanding the motivations for participation, improving communication and empowering communities. Top research priorities were long‐term health conditions, health promotion and education, early care interventions and understanding community needs. Interpretation: Discrimination and bias in health and social care provision have severe implications for worsening ethnic health inequalities. Healthcare commissioning authorities and policymakers can leverage the preference of ethnic minority groups for pharmacy services and community organisations to improve access to care. Improving research interest and engagement requires understanding individual community needs, community sensitivity, research relevance and cultural appropriateness. Patient or Public Contribution: Members of ethnic minority Patient and Public Involvement and Engagement group and Community Advisory Board supported the REPRESENT study design, conceptualisation and report development. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Lifestyle interventions delivered by eHealth in chronic kidney disease: A scoping review.
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Curtis, Ffion, Burton, James O., Butt, Ayesha, Dhaliwal, Harsimran K., Graham-Brown, Matthew M.P., Lightfoot, Courtney J., Rawat, Rishika, Smith, Alice C., Wilkinson, Thomas J., and March, Daniel S.
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CHRONIC kidney failure , *WEIGHT gain , *BLOOD pressure , *MOBILE apps , *DATABASES , *CLINICAL trial registries - Abstract
A method of overcoming barriers associated with implementing lifestyle interventions in CKD may be through the use of eHealth technologies. The aim of this review was to provide an up-to-date overview of the literature on this topic. Four bibliographical databases, two trial registers, and one database for conference proceedings were searched from inception to August 2023. Studies were eligible if they reported a lifestyle intervention using eHealth technologies. A narrative synthesis of the findings from the included studies structured around the type of eHealth intervention was presented. Where a sufficient number of studies overlapped in terms of the type of intervention and outcome measure these were brought together in a direction of effect plot. There were 54 included articles, of which 23 were randomised controlled trials (RCTs). The main component of the intervention for the included studies was mobile applications (n = 23), with the majority being in the dialysis population (n = 22). The majority of eHealth interventions were reported to be feasible and acceptable to participants. However, there was limited evidence that they were efficacious in improving clinical outcomes with the exception of blood pressure, intradialytic weight gain, potassium, and sodium. Although eHealth interventions appear acceptable and feasible to participants, there is insufficient evidence to make recommendations for specific interventions to be implemented into clinical care. Properly powered RCTs which not only demonstrate efficacy, but also address barriers to implementation are needed to enhance widespread adoption. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Corrigendum to “The prevalence and long-term health effects of long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis”
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O'Mahoney, Lauren L., Routen, Ash, Gillies, Clare, Ekezie, Winifred, Welford, Anneka, Zhang, Alexa, Karamchandani, Urvi, Simms-Williams, Nikita, Cassambai, Shabana, Ardavani, Ashkon, Wilkinson, Thomas J., Hawthorne, Grace, Curtis, Ffion, Kingsnorth, Andrew P., Almaqhawi, Abdullah, Ward, Thomas, Ayoubkhani, Daniel, Banerjee, Amitava, Calvert, Melanie, Shafran, Roz, Stephenson, Terence, Sterne, Jonathan, Ward, Helen, Evans, Rachael A., Zaccardi, Francesco, Wright, Shaney, and Khunti, Kamlesh
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- 2023
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17. Feasibility and Acceptability of a Cognitive Training Study in Individuals with Type 2 Diabetes Mellitus.
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Cooke, Samuel, Pennington, Kyla, Bridle, Chris, and Curtis, Ffion
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- 2023
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18. Facilitators and barriers to physical activity following pulmonary rehabilitation in COPD: a systematic review of qualitative studies
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Robinson, Hayley, Williams, Veronika, Curtis, Ffion, Bridle, Christopher, and Jones, Arwel W.
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- 2018
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19. Patient, family member, and ambulance staff experiences of prehospital acute pain management in adults: A systematic review and meta‐synthesis.
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Whitley, Gregory Adam, Wijegoonewardene, Nimali, Nelson, David, Curtis, Ffion, Ortega, Marishona, and Siriwardena, Aloysius Niroshan
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- 2023
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20. Examining Psychosocial and Economic Barriers to Green Space Access for Racialised Individuals and Families: A Narrative Literature Review of the Evidence to Date.
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Robinson, Tila, Robertson, Noelle, Curtis, Ffion, Darko, Natalie, and Jones, Ceri R.
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- 2023
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21. The effect of pharmacist‐led interventions on the management and outcomes in chronic kidney disease (CKD): A systematic review and meta‐analysis protocol.
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Ardavani, Ashkon, Curtis, Ffion, Khunti, Kamlesh, and Wilkinson, Thomas J.
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CHRONIC kidney failure ,CARDIOVASCULAR diseases risk factors ,DISEASE risk factors ,RANDOMIZED controlled trials ,KIDNEY physiology - Abstract
Background and Aims: Chronic kidney disease (CKD) is a progressive condition that results in a decline in kidney function over time. There are several conditions that increase the likelihood of developing CKD, particularly diabetes and hypertension. CKD increases the risk of mortality and has a detrimental impact on quality of life (QoL). Strategies for managing CKD include controlling cardiovascular risk factors and treating complications of CKD. There is an ever‐increasing role of pharmacists in managing CKD, from the optimization of risk factors to patient education. However, currently, there is a lack of data on the effect pharmacist‐led interventions have on the clinical, economic, and humanistic outcomes. Methods: This protocol, in adherence to PRISMA‐P (Preferred Reporting Items for Systematic review and Meta‐Analysis Protocols) standards, describes a prospective systematic review and meta‐analysis of randomized controlled trials, where any intervention led by a pharmacist in CKD is used. Comparison groups will consist of usual care or non‐pharmacist‐led interventions. Literature searches will be conducted in the following databases: MEDLINE, Scopus, and Web of Science. Data pertaining to clinical (e.g., mortality), economic (e.g., healthcare‐associated costs), and humanistic (e.g., QoL) outcomes will be extracted. Risk of bias will be assessed using the United States National Heart Lung and Blood Institute quality assessment tool for controlled intervention studies. A meta‐analysis will be conducted to synthesize appropriate comparable outcomes. Results: The findings of this review will be published in a peer‐reviewed journal, where the results will be presented in lay language with appropriate infographics online and via social media. Conclusion: The findings of this review can identify gaps in the literature concerning optimizing pharmacist‐led interventions in improving outcomes. In addition, this review will establish the importance of pharmacists in managing CKD patients, and whether this may result in their increased incorporation in multidisciplinary teams. [ABSTRACT FROM AUTHOR]
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- 2023
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22. A protocol for a systematic review evaluating the effectiveness of pharmacy-involved IPE activities using Kirkpatrick’s Four Level Evaluation Model
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El Nsouli, Dayana, Ahmadi, Keivan, Nelson, David, Ahmed, Syed Imran, and Curtis, Ffion
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X900 Others in Education ,B230 Pharmacy ,A900 Others in Medicine and Dentistry - Abstract
The Centre for the Advancement of Interprofessional Education (CAIPE) defines interprofessional education (IPE) as occasions when two or more professions are learning together with the objective of cultivating collaborative practice to improve the quality of care. This systematic review will utilise this definition as a basis for its inclusion criteria. This research will measure to what extent is the design of pharmacy-involved IPE activities effective through Kirkpatrick’s Four Level Training Evaluation Model? This model allows the reviewers to objectively analyse the effectiveness of a training design by evaluating its aptitude on four-levelled criteria.
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- 2021
23. The impact of the COVID‐19 pandemic on glycaemic control in people with diabetes: A systematic review and meta‐analysis.
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O'Mahoney, Lauren L., Highton, Patrick J., Kudlek, Laura, Morgan, Jessica, Lynch, Rosie, Schofield, Ella, Sreejith, Nayanika, Kapur, Ajay, Otunla, Afolarin, Kerneis, Sven, James, Olivia, Rees, Karen, Curtis, Ffion, Khunti, Kamlesh, and Hartmann‐Boyce, Jamie
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COVID-19 ,GLYCEMIC control ,PEOPLE with diabetes ,COVID-19 pandemic ,TYPE 1 diabetes ,TYPE 2 diabetes ,RANDOM effects model - Abstract
Aim: To identify, appraise and synthesize the available evidence on the impact of the coronavirus disease 2019 (COVID‐19) pandemic and lockdown (LD) on glycaemic control in people with diabetes. Materials and Methods: We searched multiple databases up to 2 February 2021 for studies reporting HbA1c, time in range (TIR), average or fasting glucose, severe hypoglycaemia and diabetic ketoacidosis. Data were pooled using random effects meta‐analysis and are presented as mean difference (MD) with 95% confidence intervals (CI). This review was preregistered on PROSPERO (CRD42020179319). Results: We include 59 studies; 44 (n = 15 464) were included in quantitative syntheses and 15 were narratively synthesized. Pooled data were grouped by diabetes type. Results from 28 studies (n = 5048 type 1 diabetes [T1D] and combined diabetes participants) showed that TIR increased during LD compared with before LD (MD 2.74%, 95% CI 1.80% to 3.69%). Data from 10 studies (n = 1294 T1D participants) showed that TIR increased after LD compared with before LD (MD 5.14%, 95% CI 3.12% to 7.16%). Pooled results from 12 studies (n = 4810 T1D and type 2 diabetes participants) resulted in average glucose decreasing after LD compared with before LD (MD –6.86 mg/dl, 95% CI –8.54 to –5.18). Results for other outcomes, including HbA1c, were not statistically significantly different. Conclusions: The COVID‐19 pandemic was associated with small improvements across multiple outcomes of glycaemic control, although there was insufficient evidence to suggest that this led to changes in HbA1c. Most evidence came from people with access to diabetes technologies in high‐income countries; more research is needed in less advantaged populations. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Physical activity and the 'pediatric inactivity triad' in children living with chronic kidney disease: a narrative review.
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Wilkinson, Thomas J., O'Mahoney, Lauren L., Highton, Patrick, Viana, Joao L., Ribeiro, Heitor S., Lightfoot, Courtney J., Curtis, Ffion, and Khunti, Kamlesh
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- 2022
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25. Evaluating follow- up and complexity in cancer clinical trials (EFACCT): an eDelphi study of research professionals’ perspectives
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Markham-Jones, Helene, Curtis, Ffion, Law, Graham, Bridle, Christopher, Boyle, Dorothy, and Ahmed, Tanweer
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B900 Others in Subjects allied to Medicine ,L510 Health & Welfare - Abstract
Objectives: To evaluate patient follow-up and complexity in cancer clinical trial delivery, using consensus methods to: (1) identify research professionals’ priorities, (2) understand localised challenges, (3) define study complexity and workloads supporting the development of a trial rating and complexity assessment tool (TRACAT). Design: A classic eDelphi completed in three rounds, conducted as the launch study to a multiphase national project (evaluating follow-up and complexity in cancer clinical trials). Setting: Multicentre online survey involving professionals at National Health Service secondary care hospital sites in Scotland and England varied in scale, geographical location and patient populations. Participants: Principal investigators at 13 hospitals across nine clinical research networks recruited 33 participants using pre-defined eligibility criteria to form a multidisciplinary panel. Main outcome measures: Statements achieving a consensus level of 70% on a 7-point Likert-type scale and ranked trial rating indicators (TRIs) developed by research professionals. Results: The panel developed 75 consensus statements illustrating factors contributing to complexity, follow-up intensity and operational performance in trial delivery, and specified 14 ranked TRIs. Seven open questions in the first qualitative round generated 531 individual statements. Iterative survey rounds returned rates of 82%, 82% and 93%. Conclusions: Clinical trials operate within a dynamic, complex healthcare and innovation system where rapid scientific advances present opportunities and challenges for delivery organisations and professionals. Panellists highlighted cultural and organisational factors limiting the profession’s potential to support growing trial complexity and patient follow-up. Enhanced communication, interoperability, funding and capacity have emerged as key priorities. Future operational models should test dialectic Singerian-based approaches respecting open dialogue and shared values. Research capacity building should prioritise innovative, collaborative approaches embedding validated review and evaluation models to understand changing operational needs and challenges. TRACAT provides a mechanism for continual knowledge assimilation to improve decision-making.
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- 2020
26. Patient‐reported symptoms and experience following Guillain‐Barré syndrome and related conditions: Questionnaire development and validation.
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Siriwardena, Aloysius Niroshan, Akanuwe, Joseph N. A., Botan, Vanessa, Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Asghar, Zahid B., and Hodgson, Timothy L.
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THERAPEUTIC use of immunoglobulins ,EXPERIMENTAL design ,RESEARCH evaluation ,RESEARCH methodology ,RESEARCH methodology evaluation ,CROSS-sectional method ,CONVALESCENCE ,PHYSICAL therapy ,PLASMA exchange (Therapeutics) ,MULTIVARIATE analysis ,REGRESSION analysis ,PATIENTS' attitudes ,SURVEYS ,SEVERITY of illness index ,MULTITRAIT multimethod techniques ,GUILLAIN-Barre syndrome ,QUESTIONNAIRES ,FACTOR analysis ,INTERPERSONAL relations ,BODY movement ,EMPLOYMENT ,SCALE analysis (Psychology) ,RESEARCH funding ,STATISTICAL sampling ,SYMPTOMS ,EVALUATION - Abstract
Background: Guillain‐Barré syndrome (GBS) is a rare inflammatory peripheral nerve disorder with variable recovery. Evidence is lacking on experiences of people with GBS and measurement of these experiences. Objective: We aimed to develop and validate an instrument to measure experiences of people with GBS. Design: We used a cross‐sectional design and online self‐administered questionnaire survey. Question domains, based on a previous systematic review and qualitative study, covered experiences of GBS, symptom severity at each stage, healthcare and factors supporting or hindering recovery. Descriptive, exploratory factor and reliability analyses and multivariable regression analysis were used to investigate the relationships between variables of interest, explore questionnaire reliability and validity and identify factors predicting recovery. Setting and Participants: People with a previous diagnosis of GBS were recruited through a social media advert. Results: A total of 291 responders, of different sexes, and marital statuses, were included, with most diagnosed between 2015 and 2019. Factor analysis showed four scales: symptoms, information provided, factors affecting recovery and care received. Positive social interactions, physical activity including physiotherapy and movement, changes made at home and immunoglobulin treatment were important for recovery. Multivariable models showed that immunoglobulin and/or plasma exchange were significant predictors of recovery. Employment and recovery factors (positive interactions, work support and changes at work or home, physical activity and therapy), though associated with recovery, did not reach statistical significance. Conclusion: The questionnaire demonstrated good internal reliability of scales and subscales and construct validity for people following GBS. Patient Contribution: Patients were involved in developing and piloting the questionnaire. [ABSTRACT FROM AUTHOR]
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- 2022
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27. Perceptions and experiences of residents and relatives of emergencies in care homes: a systematic review and metasynthesis of qualitative research.
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Curtis, Ffion, Jayawickrama, Withanage Iresha Udayangani, Laparidou, Despina, Weligamage, Dedunu, Kumarawansha, Weerapperuma Kankanamge Wijaya Sarathchandra, Ortega, Marishona, and Siriwardena, Aloysius Niroshan
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EMERGENCY medical service laws , *META-synthesis , *CINAHL database , *ONLINE information services , *PSYCHOLOGY information storage & retrieval systems , *MEDICAL databases , *INFORMATION storage & retrieval systems , *NURSING home patients , *EXTENDED families , *SYSTEMATIC reviews , *PATIENTS' attitudes , *FAMILY attitudes , *QUALITATIVE research , *NURSING care facilities , *CITATION analysis , *MEDICAL emergencies , *HOSPITAL admission & discharge , *PSYCHOSOCIAL factors , *EMERGENCY medical services , *DECISION making , *HOSPITAL care of older people , *COMMUNICATION , *MEDLINE , *HEALTH facility design & construction , *PATIENT-professional relations , *TRUST - Abstract
Background the perceptions and experiences of care home residents and their families are important for understanding and improving the quality of emergency care. Methods we conducted a systematic review and metasynthesis to understand the perceptions and experiences of care home residents and their family members who experienced medical emergencies in a care home setting. The review protocol was registered in PROSPERO (CRD42020167018). We searched five electronic databases, MEDLINE, CINAHL, PubMed, Cochrane Library and PsycINFO, supplemented with internet searches and forward and backward citation tracking from included studies and review articles. Data were synthesised thematically following the Thomas and Harden approach. The Critical Appraisal Skills Programme qualitative checklist was used to assess the quality of studies included in this review. Results of the 6,140 references retrieved, 10 studies from four countries (Australia, Canada, UK and USA) were included in the review and metasynthesis. All the included studies were assessed as being of good quality. Through an iterative approach, we developed six analytical themes: (i) infrastructure and process requirements in care homes to prevent and address emergencies; (ii) the decision to transfer to hospital; (iii) experiences of transfer and hospitalisation for older patients; (iv) good communication is vital for desirable outcomes; (v) legal, regulatory and ethical concerns and (vi) trusting relationships enabled residents to feel safe. Conclusions the emergency care experience for care home residents can be enhanced by ensuring resources, staff capacity and processes for high quality care and trusting relationships between staff, patients and relatives, underpinned by good communication and attention to ethical practice. [ABSTRACT FROM AUTHOR]
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- 2021
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28. An Update to the Overview of Reviews: Risks of and From SARS-COV-2 Infection and COVID-19 in People With Diabetes.
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Hartmann-Boyce, Jamie, Rees, Karen, Onakpoya, Igho, Otunla, Afolarin, Morris, Elizabeth, Morgan, Jessica, Highton, Patrick, Suklan, Jana, Curtis, Ffion, Goyder, Clare, O’Mahoney, Lauren, James, Olivia, Sreejith, Nayanika, Seidu, Samuel, and Khunti, Kamlesh
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PEOPLE with diabetes ,SARS-CoV-2 ,COVID-19 - Abstract
The article provides an update on the risks associated with SARS-CoV-2 and COVID-19 among individuals with diabetes. Topics discussed include the updated risk assessment for type 1 vs. type 2 diabetes concerning SARS-CoV-2, the differential impact of insulin use on COVID-19 outcomes in diabetics, and the influence of DPP-4 inhibitors on the risks.
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- 2023
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29. The predictors, barriers and facilitators to effective management of acute pain in children by emergency medical services: A systematic mixed studies review.
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Whitley, Gregory A, Hemingway, Pippa, Law, Graham R, Jones, Arwel W, Curtis, Ffion, and Siriwardena, Aloysius N
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We aimed to identify predictors, barriers and facilitators to effective pre-hospital pain management in children. A segregated systematic mixed studies review was performed. We searched from inception to 30-June-2020: MEDLINE, CINAHL Complete, PsycINFO, EMBASE, Web of Science Core Collection and Scopus. Empirical quantitative, qualitative and multi-method studies of children under 18 years, their relatives or emergency medical service staff were eligible. Two authors independently performed screening and selection, quality assessment, data extraction and quantitative synthesis. Three authors performed thematic synthesis. Grading of Recommendations Assessment, Development and Evaluation and Confidence in the Evidence from Reviews of Qualitative Research were used to determine the confidence in cumulative evidence. From 4030 articles screened, 78 were selected for full text review, with eight quantitative and five qualitative studies included. Substantial heterogeneity precluded meta-analysis. Predictors of effective pain management included: 'child sex (male)', 'child age (younger)', 'type of pain (traumatic)' and 'analgesic administration'. Barriers and facilitators included internal (fear, clinical experience, education and training) and external (relatives and colleagues) influences on the clinician along with child factors (child's experience of event, pain assessment and management). Confidence in the cumulative evidence was deemed low. Efforts to facilitate analgesic administration should take priority, perhaps utilising the intranasal route. Further research is recommended to explore the experience of the child. Registration: PROSPERO CRD42017058960 [ABSTRACT FROM AUTHOR]
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- 2021
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30. Effects of non-pharmacological interventions for insomnia in children with Autistic Spectrum Condition
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Curtis, Ffion, Siriwardena, Niro, Keogh, Sophie, Nadkarni, Amulya, Jha, Mithilesh, and Bridle, Christopher
- Subjects
mental disorders ,B990 Subjects Allied to Medicine not elsewhere classified - Abstract
Autism Spectrum Condition (ASC) is the name for a range of similar conditions that affect a person's social interaction, communication, interests and behaviour. In most cases many of the features of Autism can be recognised during early childhood. It is estimated that about 1 in every 160 children has an Autism Spectrum Condition (World Health Organisation). Further to this it is thought that between 40-80% of children with Autism have difficulties relating to sleep (Polimeni et al., 2005). Such sleep problems have been linked to a range of serious implications for the child's wellbeing. This review will explore the effects of non-pharmacological interventions for insomnia in children with autistic spectrum condition.
- Published
- 2017
31. Barriers and facilitators to self-management in people living with and beyond cancer (PLWABC): a systematic review of qualitative evidence (PROTOCOL)
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Nelson, David, Mcgonagle, Ian, Curtis, Ffion, Jones, Arwel, Kane, Ros, and Maclean, Shona
- Subjects
B900 Others in Subjects allied to Medicine ,L510 Health & Welfare - Abstract
Review question The review objectives are: To identify, evaluate and synthesise qualitative evidence that has explored the perspectives of people living with and beyond cancer regarding self-management. To utilise this data to identify, explore and explain the potential barriers and facilitators to self-management in people living with and beyond cancer. Condition or domain being studied: Engagement (or lack of) in self-management practices/behaviours, support and resources in adults (≥18) with any diagnosis of cancer who have completed treatment for cancer. Whilst there is no universal definition of self-management, in cancer survivorship, it has been defined as “awareness and active participation by the person in their recovery, recuperation, rehabilitation, to minimise the consequences of treatment, promote survival, health and wellbeing” (DH, Macmillan Cancer Support, NHS Improvement, 2013). This definition will be used for the purposes of this review.
- Published
- 2017
32. Patients' experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research.
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Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph, Jackson, Jennifer, Hodgson, Timothy L., and Siriwardena, A. Niroshan
- Subjects
- *
PATIENTS' attitudes , *GUILLAIN-Barre syndrome , *QUALITATIVE research , *INTERNET searching , *SENSORY perception - Abstract
Background: Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy, with an incidence of 1-2/100,000 per year. Its severity is variable, ranging from very mild cases with brief weakness to severe paralysis, leading to inability to breathe independently, or even death. Currently there is limited evidence exploring the experiences of GBS patients. The aim of this study was to review patients' experiences and perceptions of GBS and its variants at diagnosis, discharge and during recovery, by conducting a systematic review and thematic meta-synthesis of qualitative studies of patients' experiences of GBS (and its variants). Methods: We searched twelve electronic databases, supplemented with internet searches and forward and backward citation tracking from the included studies and review articles. Data were synthesised thematically following the Thomas and Harden approach. The CASP Qualitative Checklist was used to assess the quality of the included studies of this review. Results: Our search strategy identified a total of 5,282 citations and after removing duplicates and excluding citations based on title and abstract, and full-text screening, five studies were included in the review and meta-synthesis; all included studies were considered of acceptable quality. Through constant discussions and an iterative approach, we developed six analytical themes following a patient's journey from suspecting that they had a health problem, through to being hospitalised, experiencing ongoing difficulties, slowly recovering from GBS, adjusting to their new circumstances, and re-evaluating their lives. Conclusions: Despite the variety of experiences, it was evident from all included studies that being diagnosed with and surviving GBS was a life-changing experience for all participants. Trial registration: Protocol was registered (CRD42019122199) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO). [ABSTRACT FROM AUTHOR]
- Published
- 2021
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33. Efficacy of supervised exercise following pulmonary rehabilitation on health status: systematic review protocol
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Jenkins, Alex, Curtis, Ffion, Jones, Arwel, and Gowler, Holly
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B900 Others in Subjects allied to Medicine ,respiratory tract diseases - Abstract
Condition or domain being studied Chronic Obstructive Pulmonary disease (COPD) is defined as a preventable and treatable disease characterised by airflow limitation that is not fully reversible (GOLD, 2010). COPD is now the third leading cause of mortality worldwide (British Thoracic Society, 2006). The main cause for hospitalisations in COPD is exacerbations of respiratory symptoms (World Health Organisation, 2012). Review question To assess the efficacy of continued supervised exercise training following completion of pulmonary rehabilitation on COPD-related health status.
- Published
- 2017
34. Investigating the effect of exercise, cognitive, and dual-task interventions upon cognitive function in type 2 diabetes mellitus: systematic review protocol
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Cooke, Samuel, Curtis, Ffion, Bridle, Christopher, Jones, Arwel, Robinson, Hayley, and Simmons, Laura
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endocrine system diseases ,nutritional and metabolic diseases ,B100 Anatomy, Physiology and Pathology - Abstract
Condition or domain being studied Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, characterised by hyperglycaemia, and precipitated as a result of abnormalities in glucose metabolism (Scheen, 2003). Evidence suggests that T2DM is associated with an accelerated or increased risk of cognitive decline, increasing the risk of dementia (Reijmer et al, 2010). Exercise, cognitive, and dual-task interventions have been shown effective in improving cognition in healthy populations (Theil et al., 2013; Eggenberger et al., 2015), although the effects of such interventions upon cognition in T2DM are unclear. Review question(s) What are the effects of exercise interventions upon cognitive function in type 2 diabetes? What are the effects of cognitive interventions upon cognitive function in type 2 diabetes? What are the effects of dual-task interventions upon cognitive function in type 2 diabetes?
- Published
- 2017
35. A 15-week vitamin D supplementation and indoor cycling intervention reduces exercising heart rate, with no effect on glycaemic control in healthy adults: A pilot investigation
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Curtis, Ffion, Thatcher, Rhys, Rice, Sam, and Davison, Glen
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RC1200 ,B190 Anatomy, Physiology and Pathology not elsewhere classified ,RC1235 ,RA784 ,B990 Subjects Allied to Medicine not elsewhere classified ,QP ,B120 Physiology - Abstract
Significant positive correlations are often observed between vitamin D concentrations and physical activity levels. Whilst this may be due to individuals who are physically active spending time outdoors (i.e. increased opportunity for vitamin D synthesis), there is growing evidence to suggest a more complex relationship between vitamin D status, physical fitness and health outcomes. To explore this further thirty-nine healthy adults were randomly allocated to 15 weeks of exercise training (Ex), no training (NoEx), 2000 IU/day vitamin D (VitD) and/or placebo (Pla) supplementation (giving four possible allocations: NoEx+VitD; NoEx+Pla; Ex+VitD; Ex+Pla). Vitamin D status, glycaemic control and exercise responses were measured pre- and post-intervention. A series of 2 x 2 ANOVAs failed to find any effect of supplementation or exercise on any of the measures except heart rate during low intensity exercise, and vitamin D status. Heart rate was significantly reduced (6%, p < 0.05) in the Ex+VitD group. Vitamin D status was significantly raised (28%, p < 0,05) in the supplementation groups (NoEx+VitD and Ex+VitD) at a time of year (August-November) when a seasonal decline was observed in the placebo groups (33%, p < 0.05). These findings indicate that vitamin D supplementation (2000 IU/day) may have an enhancing role alongside exercise in inducing cardiorespiratory adaptations to exercise training. Further investigations are required to confirm these findings and identify the mechanisms involved.
- Published
- 2017
36. Agreement between session RPE and individual training impulse across a range of running speeds
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Curtis, Ffion and Thatcher, Rhys
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B190 Anatomy, Physiology and Pathology not elsewhere classified ,B120 Physiology - Abstract
BACKGROUND: The training impulse (TRIMP) provides a means of quantifying training dose during physical training; it is traditionally based on the heart rate response to exercise and involves establishing the heart rate – blood lactate relationship. A new approach is based on the individual’s global rating of perceived exertion (RPE) for the training session. The current study was undertaken to examine agreement between individual TRIMP and session RPE. METHODS: Nine healthy male volunteers completed three trials involving a 6 km treadmill run at speeds of 12 km×h-1, 9 km×h-1 and 7.2 km×h-1 in random order. Individual training impulse and session rating of perceived exertion were calculated for each trial. RESULTS: While both methods resulted in values increasing as the intensity of the trials increased there were no significant differences between the three trials for either method. There was a significant correlation between the two methods (N.=27) (r = 0.62, P
- Published
- 2016
37. Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study.
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Akanuwe, Joseph N. A., Laparidou, Despina, Curtis, Ffion, Jackson, Jennifer, Hodgson, Timothy L., and Siriwardena, Aloysius Niroshan
- Subjects
COMMUNICATION ,CONVALESCENCE ,EXPERIENCE ,HOSPITAL care ,INTERVIEWING ,NEEDS assessment ,OCCUPATIONS ,GUILLAIN-Barre syndrome ,HEALTH self-care ,QUALITATIVE research ,JUDGMENT sampling ,SOCIAL support ,ACCESS to information ,SPIRITUAL care (Medical care) ,INFORMATION needs ,HEALTH literacy ,EARLY diagnosis ,DATA analysis software ,PATIENTS' attitudes - Abstract
Background: Guillain‐Barré syndrome (GBS) is a rare inflammatory disorder affecting the peripheral nerves. Although typically there is full neurological recovery, some people continue to experience residual physical, psychological or social problems longer term. Evidence describing the experiences of people with GBS is limited. Objective: We aimed to explore the experiences of people with GBS in the UK. Design: We used qualitative (face‐to‐face and telephone) interviews to explore experiences of people with GBS. Audio‐recorded data were transcribed verbatim and analysed using the Framework Method supported by NVivo 11. Setting and Participants: We purposively recruited a sample of 16 volunteers with a prior diagnosis of GBS of varying age, sex, ethnicity, location, marital status, time since diagnosis and length of hospital stay to maximize differences in experience. Interviewees were required to have been discharged from hospital, able to give informed consent, able to speak and understand English and currently resident in the United Kingdom. Results: The key themes arising from the analysis were as follows: the importance of early diagnosis; the experiences of inpatient care; the importance of active support for recovery; the need for communication throughout the course of the illness; the need for greater awareness, knowledge and provision of information by health‐care staff; and path to achieving function. Conclusion: This is the first qualitative study exploring experiences of people with GBS in the UK through their whole illness journey from onset to recovery. The findings contribute to our understanding of the experiences and support needs of people recovering from GBS. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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38. Effects of exercise, cognitive, and dual-task interventions on cognition in type 2 diabetes mellitus: A systematic review and meta-analysis.
- Author
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Cooke, Samuel, Pennington, Kyla, Jones, Arwel, Bridle, Chris, Smith, Mark F., and Curtis, Ffion
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AMED (Information retrieval system) ,TYPE 2 diabetes ,CLINICAL trial registries ,TRAIL Making Test ,SELECTION bias (Statistics) ,SHORT-term memory ,COGNITION ,EXERCISE - Abstract
Introduction: Previous evidence has shown significant effects of exercise, cognitive and dual-task training for improving cognition in healthy cohorts. The effects of these types of interventions in type 2 diabetes mellitus is unclear. The aim of this research was to systematically review evidence, and estimate the effect, of exercise, cognitive, and dual-task interventions on cognition in type 2 diabetes mellitus. Method: Electronic databases including PubMed, EMBASE, CINAHL, PsycINFO, SPORTDiscus, and MEDLINE were searched for ongoing and completed interventional trials investigating the effect of either an exercise, cognitive or dual-task intervention on cognition in type 2 diabetes mellitus. Results: Nine trials met the inclusion criteria–one dual-task, two cognitive, and six exercise. Meta-analyses of exercise trials showed no significant effects of exercise on measures of executive function (Stroop task, SMD = -0.31, 95% CI -0.71–0.09, P = 0.13, trail making test part A SMD = 0.28, 95% CI -0.20–0.77 P = 0.25, trail making test part B SMD = -0.15, 95% CI -0.64–0.34 P = 0.54, digit symbol SMD = 0.09, 95% CI -0.39–0.57 P = 0.72), and memory (immediate memory SMD = 0.20, 95% CI -0.28–0.69, P = 0.41 and delayed memory SMD = -0.06, 95% CI -0.55–0.42, P = 0.80). A meta-analysis could not be conducted using cognitive or dual-task data, but individual trials did report a favourable effect of interventions on cognition. Risk of bias was considered moderate to high for the majority of included trials. Conclusions: Meta-analyses of exercise trials identified a small effect size (0.31), which whilst not significant warrants further investigation. Larger and more robust trials are needed that report evidence using appropriate reporting guidelines (e.g. CONSORT) to increase confidence in the validity of results. Trial registration: Protocol was registered (CRD42017058526) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO). [ABSTRACT FROM AUTHOR]
- Published
- 2020
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39. Evaluating follow-up and complexity in cancer clinical trials (EFACCT): an eDelphi study of research professionals’ perspectives.
- Author
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Jones, Helene Markham, Curtis, Ffion, Law, Graham, Bridle, Christopher, Boyle, Dorothy, and Ahmed, Tanweer
- Abstract
Objectives To evaluate patient follow-up and complexity in cancer clinical trial delivery, using consensus methods to: (1) identify research professionals’ priorities, (2) understand localised challenges, (3) define study complexity and workloads supporting the development of a trial rating and complexity assessment tool (TRACAT). Design A classic eDelphi completed in three rounds, conducted as the launch study to a multiphase national project (evaluating follow-up and complexity in cancer clinical trials). Setting Multicentre online survey involving professionals at National Health Service secondary care hospital sites in Scotland and England varied in scale, geographical location and patient populations. Participants Principal investigators at 13 hospitals across nine clinical research networks recruited 33 participants using pre-defined eligibility criteria to form a multidisciplinary panel. Main outcome measures Statements achieving a consensus level of 70% on a 7-point Likert-type scale and ranked trial rating indicators (TRIs) developed by research professionals. Results The panel developed 75 consensus statements illustrating factors contributing to complexity, follow-up intensity and operational performance in trial delivery, and specified 14 ranked TRIs. Seven open questions in the first qualitative round generated 531 individual statements. Iterative survey rounds returned rates of 82%, 82% and 93%. Conclusions Clinical trials operate within a dynamic, complex healthcare and innovation system where rapid scientific advances present opportunities and challenges for delivery organisations and professionals. Panellists highlighted cultural and organisational factors limiting the profession’s potential to support growing trial complexity and patient follow-up. Enhanced communication, interoperability, funding and capacity have emerged as key priorities. Future operational models should test dialectic Singerian-based approaches respecting open dialogue and shared values. Research capacity building should prioritise innovative, collaborative approaches embedding validated review and evaluation models to understand changing operational needs and challenges. TRACAT provides a mechanism for continual knowledge assimilation to improve decision-making. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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40. Effectiveness of non-pharmacological interventions for insomnia in children with Autism Spectrum Disorder: A systematic review and meta-analysis.
- Author
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Keogh, Sophie, Bridle, Christopher, Siriwardena, Niroshan A., Nadkarni, Amulya, Laparidou, Despina, Durrant, Simon J., Kargas, Niko, Law, Graham R., and Curtis, Ffion
- Subjects
CHILDREN with autism spectrum disorders ,AUTISTIC children ,META-analysis ,AUTISM spectrum disorders ,INSOMNIA - Abstract
Background: Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders characterised by behavioural, communication and social impairments. The prevalence of sleep disturbances in children with ASD is 40–80%, with significant effects on quality of life for the children and carers. This systematic review aimed to synthesise evidence of the effects of behavioural interventions to improve sleep among children with ASD. Methods: Databases (MEDLINE, PsycINFO, CINAHL, ScienceDirect, Autism Data, CENTRAL, ClinicalTrials.gov and Current Controlled Trials) were searched for published, unpublished and ongoing randomised controlled trials evaluating the effect of non-pharmacological interventions for insomnia in children with autism spectrum conditions. Results: Three studies met the inclusion criteria, one provided actigraphy data, one Children’s Sleep Habits Questionnaire (CSHQ) data, and one both actigraphy and CSHQ data for use in meta-analyses. There were significant differences between the behavioural intervention and comparison groups (actigraphy data) for total sleep time (24.41 minutes, 95% CI 5.71, 43.11, P = 0.01), sleep latency (-18.31 minutes, 95% CI -30.84, -5.77, P = 0.004) and sleep efficiency (5.59%, 95% CI 0.87, 10.31, P = 0.02). There was also a favourable intervention effect evident for the subjective CSHQ data (-4.71, 95% CI -6.70, -2.73, P<0.00001). Risk of bias was low across several key domains (randomisation, allocation concealment and reporting), with some studies being unclear due to poor reporting. Conclusions: There are very few high quality randomised controlled trials in this area. Here we provide initial synthesised quantitative evidence of the effectiveness of behavioural interventions for treating sleep problems in children with ASD. Trial registration: Protocol was registered () on the International Prospective Register of Systematic Reviews (). [ABSTRACT FROM AUTHOR]
- Published
- 2019
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41. Effects of intradialytic cycling exercise on exercise capacity, quality of life, physical function and cardiovascular measures in adult haemodialysis patients: a systematic review and meta-analysis.
- Author
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Young, Hannah M L, March, Daniel S, Graham-Brown, Matthew P M, Jones, Arwel W, Curtis, Ffion, Grantham, Charlotte S, Churchward, Darren R, Highton, Patrick, Smith, Alice C, and Singh, Sally J
- Subjects
CYCLING ,HEMODIALYSIS ,KIDNEY disease treatments ,CARDIOVASCULAR diseases ,OLDER people ,MEDICAL databases ,PATIENTS ,THERAPEUTICS - Abstract
Background Intradialytic cycling (IDC), delivered during haemodialysis (HD), has the potential to improve many health issues. This systematic review and meta-analysis examine the evidence on the effects of IDC on exercise capacity, quality of life (QoL), physical function and cardiovascular health. Methods Twenty-four databases were searched alongside Internet and hand searching, and consultation with experts. Eligibility criteria were cluster randomized, randomized and quasi-randomized controlled trials (RCTs) of IDC versus usual care in prevalent adult HD patients. Primary outcome measures were exercise capacity (VO
2 peak and field tests) and QoL. Secondary measures were cardiac and physical function. Results Thirteen RCTs were eligible. Eight provided data for use in meta-analyses, which indicated no significant change in VO2 peak (mean difference, MD 1.19 mL/kg/min, 95% confidence interval −1.15 to 3.52, P = 0.3), physical (mean change, MC 1.97, −8.27 to 12.22, P = 0.7) or mental component (MC 3.37, −7.94 to 14.68, P = 0.6) summary scores of the Medical Outcomes Short Form 36, pulse wave velocity (MD −0.57 m/s, −1.55 to 0.41, P = 0.4), systolic (MD −2.28 mmHg, −14.46 to 9.90, P = 0.7) or diastolic blood pressure (MD 2.25 mmHg, −3.01 to 7.50, P = 0.4) following IDC. IDC, however, leads to an improvement in performance on the 6-min walk test (MD 87.84 m, 39.60–136.09, P = 0.0004). All included studies were considered to have high risk of bias. Conclusions There is insufficient evidence demonstrating whether cycling exercise during HD improves patient outcomes. High-quality, adequately powered RCTs of IDC are required. [ABSTRACT FROM AUTHOR]- Published
- 2018
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42. Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health care use: a systematic review and meta-analysis.
- Author
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Jenkins, Alex R, Gowler, Holly, Curtis, Ffion, Holden, Neil S, Bridle, Christopher, and Jones, Arwel W
- Published
- 2018
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43. Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials.
- Author
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Jones, Arwel W., March, Daniel S., Curtis, Ffion, and Bridle, Christopher
- Subjects
RESPIRATORY infections ,PHYSICAL training & conditioning ,COLOSTRUM ,META-analysis ,RANDOMIZED controlled trials ,SYSTEMATIC reviews ,PLACEBOS ,DISEASE risk factors - Abstract
Background: Bovine colostrum is proposed as a nutritional countermeasure to the risk of upper respiratory symptoms (URS) during exercise training. The aim of this systematic review and meta-analysis was to estimate the size of the effect of bovine colostrum supplementation on URS. Methods: Databases (CDSR, CENTRAL, Cinahl, ClinicalTrials.gov, Current Controlled Trials, DARE, EMBASE, Medline, PROSPERO and Web of Science) of published, unpublished and ongoing studies were searched for randomised controlled trials of healthy adults (⩾18 years), evaluating the effect of oral bovine colostrum supplementation compared to a concurrent control group on URS. Results: Five trials (152 participants) met the inclusion criteria, all of which involved individuals involved in regular exercise training. Over an 8-12 week follow-up period, bovine colostrum supplementation when compared to placebo significantly reduced the incidence rate of URS days (rate ratio 0.56, 95 % confidence intervals 0.43 to 0.72, P value < 0.001) and URS episodes (0.62, 0.40 to 0.99, P value = 0.04) by 44 and 38 % respectively. There were limited data and considerable variation in results of included studies for duration of URS episodes hence a meta-analysis of this outcome was deemed inappropriate. The risk of bias assessment in this review was hindered by poor reporting practices of included studies. Due to incomplete reporting of study methods, four of the five studies were judged to have a moderate or high risk of overall bias. Our findings must be interpreted in relation to quantity and quality of the available evidence. Conclusions: The present systematic review and meta-analysis provides evidence that bovine colostrum supplementation may be effective in preventing the incidence of URS days and episodes in adults engaged in exercise training. The fact that the majority of included studies did not report significant effects on URS outcomes mitigates concerns about publication bias. The point estimates of the random-effects meta-analyses are greater than the smallest clinically important difference, but the low precision of the individual study estimates means the evidence presented in this review needs to be followed up with an appropriately designed and adequately powered, randomised control trial. Trial registration: Protocol was registered (CRD42015014925) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO/). [ABSTRACT FROM AUTHOR]
- Published
- 2016
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44. Corrigendum to: Perceptions and experiences of residents and relatives of emergencies in care homes: a systematic review and metasynthesis of qualitative research.
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Curtis, Ffion, Jayawickrama, Withanage Iresha Udayangani, Laparidou, Despina, Weligamage, Dedunu, Kumarawansha, Weerapperuma Kankanamge Wijaya Sarathchandra, Ortega, Marishona, and Siriwardena, Aloysius Niroshan
- Subjects
- *
PATIENTS' attitudes , *MEDICAL emergencies , *NURSING care facilities - Abstract
A correction is presented to the article "Perceptions and Experiences of Residents and Relatives of Emergencies in Care Homes: A Systematic Review and Metasynthesis of Qualitative Research" which appeared in a previous issue.
- Published
- 2022
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45. Patient‐reported outcomes in diabetes‐related foot conditions: Is patient experience influenced by ethnicity? A mixed‐methods systematic review.
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Highton, Patrick, Jeffers, Shavez, Butt, Ayesha, O'Mahoney, Lauren, Jenkins, Sian, Abdala, Ruksar, Haddon, Louise, Gillies, Clare, Curtis, Ffion, Hadjiconstantinou, Michelle, and Khunti, Kamlesh
- Subjects
- *
PATIENT experience , *DIABETIC foot , *PATIENTS' attitudes , *SOCIODEMOGRAPHIC factors , *ETHNICITY - Abstract
Aims Methods Results Conclusions Research in diabetes‐related foot conditions (DRFC) often focuses on ulcer‐related care, whilst the patient experience and influence of sociodemographic factors are under‐researched. This systematic review investigated patient‐reported outcomes and experience in people with DRFC.Multiple databases were searched from inception to 16 August 2023. All original articles that assessed any patient‐reported outcome or experience in DRFC and reported participant ethnicity were included. Data were synthesized using a sequential contingent approach. Study quality was assessed using study design‐specific tools.Twenty‐three studies were included (11 qualitative, 11 quantitative and one mixed‐methods). DRFC had a largely negative impact on various life dimensions, including social and daily life, work, emotional and psychological well‐being, necessitating dependence on others in the form of emotional, social and/or religious support, which were experienced differently by different groups. Patient DRFC knowledge and self‐care habits were typically suboptimal, and levels of hope and feeling of control over their condition varied between groups. Outcomes varied slightly between ethnicities across studies, with some ethnicity‐specific themes identified such as beliefs about disease cause and footwear habits. Quantitative and qualitative findings were mostly congruent.DRFC profoundly and negatively impacts patient‐reported outcomes and experience, with limited evidence suggesting an influence of ethnicity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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46. Effects of cognitive behavioural therapy on insomnia in adults with tinnitus: Systematic review and meta-analysis of randomised controlled trials.
- Author
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Curtis, Ffion, Laparidou, Despina, Bridle, Chris, Law, Graham R, Durrant, Simon, Rodriguez, Alina, Pierzycki, Robert H, and Siriwardena, Aloysius N
- Abstract
Insomnia is common in patients with tinnitus and negatively affects tinnitus symptoms and quality of life. This systematic review aimed to synthesise evidence of the effectiveness of cognitive behavioural therapy (CBT) based interventions on insomnia in adults with tinnitus. We conducted a comprehensive database search (MEDLINE, CINAHL, Web of Science, CENTRAL, ClinicalTrials.gov and PROSPERO) for published, unpublished and ongoing randomised controlled trials of CBT in adults with tinnitus. Five trials met the inclusion criteria for the systematic review, with four of these providing data for the meta-analysis. This demonstrated a statistically significant reduction in Insomnia Severity Index (a standard diagnostic questionnaire of insomnia used in clinical settings) following CBT (-3.28, 95% CI -4.51, -2.05, P=<0.001). There was no evidence of statistical heterogeneity (I2 = 0%). Risk of bias was considered low in all categories except blinding of participants, personnel, and/or the assessment of outcomes. Here, for the first time, we demonstrate that CBT-based interventions can significantly improve sleep in adults with tinnitus. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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47. The impact of the COVID-19 pandemic and associated disruptions in health-care provision on clinical outcomes in people with diabetes: a systematic review.
- Author
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Hartmann-Boyce J, Highton P, Rees K, Onakpoya I, Suklan J, Curtis F, O'Mahoney L, Morris E, Kudlek L, Morgan J, Lynch R, Marpadga S, Seidu S, and Khunti K
- Subjects
- Adult, Child, Female, Adolescent, Humans, Pandemics, Ethnicity, Minority Groups, COVID-19 epidemiology, Diabetic Foot, Diabetes Mellitus epidemiology, Diabetes Mellitus therapy
- Abstract
The COVID-19 pandemic triggered disruptions to health care and lifestyles that could conceivably impact diabetes management. We set out to identify the impact of disruptions caused by COVID-19 on clinical outcomes in people with diabetes. We performed a systematic review of the available literature in the MEDLINE and OVID databases from Jan 1, 2020, to June 7, 2023, and included 138 studies (n>1 000 000 people). All but five studies were judged to be at some risk of bias. All studies compared prepandemic with pandemic periods. All-cause mortality (six studies) and diabetes-related mortality (13 studies) showed consistent increases, and most studies indicated increases in sight loss (six studies). In adult and mixed samples, data generally suggested no difference in diabetic ketoacidosis frequency or severity, whereas in children and adolescents most studies showed increases with some due to new-onset diabetes (69 studies). Data suggested decreases in hospital admissions in adults but increases in diabetes-related admissions to paediatric intensive care units (35 studies). Data were equivocal on diabetic foot ulcer presentations (nine studies), emergency department admissions (nine studies), and overall amputation rates (20 studies). No studies investigated renal failure. Where reported, the impact was most pronounced for females, younger people, and racial and ethnic minority groups. Further studies are needed to investigate the longer-term impact of the pandemic and the on potential differential impacts, which risk further exacerbating existing inequalities within people with diabetes., Competing Interests: Declaration of interests SS reports receiving grants from Sanofi, AstraZeneca, Novo Nordisk, Boehringer Ingelheim, and Servier; speaker honoraria from Boehringer Ingelheim, Lilly, MSD, Novartis, Novo Nordisk, Janssen, Amgen, Sanofi, AstraZeneca, Abbott, and Menarini; advisory board honoraria from Boehringer Ingelheim, Lilly, Novo Nordisk, AstraZeneca, and Abbott; and support for attending meetings or travel from AstraZeneca, Abbott, and Menarini. KK reports acting as a consultant or speaker for or receiving grants for investigator-initiated studies from AstraZeneca, Abbott, Amgen, Bayer, Novartis, Novo Nordisk, Roche, Servier, Sanofi-Aventis, Lilly, MSD, Boehringer Ingelheim, Oramed Pharmaceuticals, and Applied Therapeutics; and being chair of the Scientific Advisory Group for Emergencies Ethnicity Subgroup. All other authors declare no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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48. Cardiovascular disease prevention: Community Based Asset Mapping within religious networks in a rural Sub-Saharan African neighbourhood.
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Willis A, Chatio S, Darko N, Nonterah EA, Zakariah-Akoto S, Alale J, Jones CR, Curtis F, Kunutsor S, Ansah PO, and Seidu S
- Abstract
Prevalence of conditions which raise cardiovascular risk, such as hypertension and type 2 diabetes are seeing a dramatic rise in Sub Saharan Africa. A large proportion of these cases remain undiagnosed and there is limited resource to provide patients with self-management support and education once diagnosed. This study aimed to identify and catalogue community-based assets for the purposes of developing and deploying a screening and education programme for cardiometabolic risk factors (diabetes and hypertension) within religious organisations in a local community in a rural Ghanaian context. We utilised a community-based form of participatory research made up of a number of different components including community-based asset mapping and stakeholder consultation, supplemented by 18 in-depth interviews and 10 focus groups with n = 115 service users, to map existing assets with relevance to cardiometabolic health in this setting and context. Thematic analysis of interview and focus group data was performed to identify themes related to successful implementation of health screening. Two stakeholder workshops with local healthcare professionals, faith leaders and health policy makers were delivered to co-produced a prioritised list of recommendations and 'asset map' to aid deployment of mass screening within faith organisations in this context. The findings of this research highlight a number of 'hidden' community assets and motivational mechanisms at an individual, community and institutional levels; these have informed a list of recommendations which have been co-developed with the stakeholder group and local community to support the development of effective screening strategies for cardiometabolic conditions within faith organisations in this context. We have identified key mechanisms and assets which would support a sustainable screening approach designed to engage an underserved community at high CVD risk to promote general community health and well-being., Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: SS is in receipt of: Speaker honoraria from: AstraZeneca, Boehringer Ingelheim, Janssen, Lilly, MSD, Novo Nordisk, SB Communications, OmniaMed, Roche, Napp, NB Medical, Amgen, Advisory board honoraria from: AstraZeneca, Lilly, Boehringer Ingelheim, Janssen, MSD, Novo Nordisk, Takeda, Sanofi, Educational grants from: Boehringer Ingelheim, Lilly, Novo Nordisk, Takeda, Conference registration and subsistence from: Boehringer Ingelheim, Janssen, Lilly, Novo Nordisk, Takeda. All other authors have declared that no competing interests exist., (Copyright: © 2023 Willis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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49. Examining Psychosocial and Economic Barriers to Green Space Access for Racialised Individuals and Families: A Narrative Literature Review of the Evidence to Date.
- Author
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Robinson T, Robertson N, Curtis F, Darko N, and Jones CR
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- Humans, Narration, Ethnicity, Parks, Recreational
- Abstract
Background: Social prescribing (such as green social prescribing), aims to address health disparities cross-culturally to improve well-being. However, evidence highlights racial disparities in relation to access to quality green space (including local/national parks and recreational spaces). This review aimed to identify the psycho-socioeconomic barriers to green space access for racialised individuals/families and Black Indigenous People of Colour (BIPOC), to understand what cultural adaptations might be made to help support them to access green social prescribing within the UK., Method: A narrative systematic review was conducted to identify barriers to green space access for racialised individuals/families and BIPOC. Searches of publication databases (APA PsycInfo, Cochrane Database of Systematic Reviews [CDSR], Cochrane Central Register of Controlled Trials [CENTRAL], Cumulated Index to Nursing and Allied Health Literature [CINAHL], and SCOPUS Preview) were undertaken from January to February 2022, to identify quantitative peer reviewed studies. Of the 4493 abstracts identified, ten studies met the inclusion criteria and were included for final review., Results: The results suggest that interpersonal, practical (such as transportation costs, entrance fees and lodging costs) and environmental factors can act as barriers to green space access for racialised individuals/families. Most frequently reported barriers were perceptions of safety and costs associated with travel and accessing green spaces, particularly for families., Conclusion: Factors such as diversity-friendly schemes (e.g., multiple languages on signs and additional prayer spaces in parks), funding and strategies to improve safety should be considered in the design and commissioning of green space and green social prescribing initiatives in primary care. By mitigating these barriers green space can become more accessible and improve inclusivity for racialised individuals/families. Future research could explore the inter-racial differences between racialised populations and which mechanisms reduce barriers to access and in what contexts.
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- 2022
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50. The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: A systematic review and meta-analysis.
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O'Mahoney LL, Routen A, Gillies C, Ekezie W, Welford A, Zhang A, Karamchandani U, Simms-Williams N, Cassambai S, Ardavani A, Wilkinson TJ, Hawthorne G, Curtis F, Kingsnorth AP, Almaqhawi A, Ward T, Ayoubkhani D, Banerjee A, Calvert M, Shafran R, Stephenson T, Sterne J, Ward H, Evans RA, Zaccardi F, Wright S, and Khunti K
- Abstract
Background: The aim of this study was to systematically synthesise the global evidence on the prevalence of persistent symptoms in a general post COVID-19 population., Methods: A systematic literature search was conducted using multiple electronic databases (MEDLINE and The Cochrane Library, Scopus, CINAHL, and medRxiv) until January 2022. Studies with at least 100 people with confirmed or self-reported COVID-19 symptoms at ≥28 days following infection onset were included. Patient-reported outcome measures and clinical investigations were both assessed. Results were analysed descriptively, and meta-analyses were conducted to derive prevalence estimates. This study was pre-registered (PROSPERO-ID: CRD42021238247)., Findings: 194 studies totalling 735,006 participants were included, with five studies conducted in those <18 years of age. Most studies were conducted in Europe (n = 106) or Asia (n = 49), and the time to follow-up ranged from ≥28 days to 387 days. 122 studies reported data on hospitalised patients, 18 on non-hospitalised, and 54 on hospitalised and non-hospitalised combined (mixed). On average, at least 45% of COVID-19 survivors, regardless of hospitalisation status, went on to experience at least one unresolved symptom (mean follow-up 126 days). Fatigue was frequently reported across hospitalised (28.4%; 95% CI 24.7%-32.5%), non-hospitalised (34.8%; 95% CI 17.6%-57.2%), and mixed (25.2%; 95% CI 17.7%-34.6%) cohorts. Amongst the hospitalised cohort, abnormal CT patterns/x-rays were frequently reported (45.3%; 95% CI 35.3%-55.7%), alongside ground glass opacification (41.1%; 95% CI 25.7%-58.5%), and impaired diffusion capacity for carbon monoxide (31.7%; 95% CI 25.8%-3.2%)., Interpretation: Our work shows that 45% of COVID-19 survivors, regardless of hospitalisation status, were experiencing a range of unresolved symptoms at ∼ 4 months. Current understanding is limited by heterogeneous study design, follow-up durations, and measurement methods. Definition of subtypes of Long Covid is unclear, subsequently hampering effective treatment/management strategies., Funding: No funding., Competing Interests: This work was supported by National Institute for Health Research (NIHR) ARC East Midlands. AB is PI of the NIHR funded STIMULATE-ICP study (COV-LT2-0043) and has also received other research funding from Astra Zeneca, NIHR, BMA, UK Research and Innovation (UKRI) and EU. MC is Director of the Birmingham Health Partners Centre for Regulatory Science and Innovation, Director of the Centre for the Centre for Patient Reported Outcomes Research and is a NIHR Senior Investigator. MC receives funding from the NIHR, UKRI, NIHR Birmingham Biomedical Research Centre, the NIHR Surgical Reconstruction and Microbiology Research Centre, NIHR ARC West Midlands, UK SPINE, European Regional Development Fund–Demand Hub and Health Data Research UK at the University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Innovate UK (part of UKRI), Macmillan Cancer Support, UCB Pharma, Janssen, GSK and Gilead. She is senior author of the Symptom Burden Questionnaire™ for Long COVID. MC has received personal fees from Aparito Ltd, CIS Oncology, Takeda, Merck, Daiichi Sankyo, Glaukos, GSK and the Patient-Centered Outcomes Research Institute (PCORI) outside the submitted work. In addition, a family member owns shares in GSK. TS and RS receive funding from the NIHR, and by the UKRI who have awarded funding grant number COVLT0022. All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. HW is an NIHR Senior Investigator Award, and acknowledges support from the NIHR Imperial Biomedical Research Centre, Health Data Research UK, NIHR Applied Research Collaborative North West London, and the Wellcome Trust. KK is Chair of the Ethnicity Subgroup of the UK Scientific Advisory Group for Emergencies (SAGE) and Member of SAGE and also Chair of the National Long Covid working group which reports to the Chief Medical Officer. TW receives funding from the NIHR, the views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. JS receives funding from the NIHR and UKRI., (© 2022 The Author(s).)
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- 2022
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