7 results on '"Cui-Wei Li"'
Search Results
2. Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures
- Author
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Deng, Wei-min, Zhang, Peng, Huang, Hai, Shen, You-gao, Yang, Qin-hua, Cui, Wei-li, He, Yang-shu, Wei, Song, Ye, Zhu, Liu, Fang, and Qin, Ling
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- 2012
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3. Treating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence
- Author
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Wei Ping Hu, Ben Ma, Yu Wang, Li Cheng Tan, Qinghai Ji, Cui Wei Li, Xiao Shi, Peng Cheng Yu, Wen Jun Wei, and Yu-Long Wang
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medicine.medical_specialty ,lcsh:RC648-665 ,Article Subject ,Endocrine and Autonomic Systems ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Central compartment ,030209 endocrinology & metabolism ,Neck dissection ,Disease ,Gastroenterology ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Node negative ,Thyroid carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,030220 oncology & carcinogenesis ,Internal medicine ,Epidemiology ,medicine ,Radioactive iodine therapy ,business ,Prospective cohort study - Abstract
Forcher and Contributor ID) account on MTS. To register a linked ORCID account, please go to the Account Update page (http://mts.hindawi.com/update/) in our Manuscript Tracking System and after you have logged in click on the ORCID link at the top of the page. This link will take you to the ORCID website where you will be able to create an account for yourself. Once you have done so, your new ORCID will be saved in our Manuscript Tracking System automatically."?> the rare but aggressive insular thyroid carcinoma (ITC), there's no clear evidence to determine whether prophylactic central compartment neck dissection (CCND) is necessary for cN0 disease. This study provides the first evidence that treating cN0 ITC without prophylactic CCND is associated with decreased survival regardless of T staging and administration of RAI therapy. Background. Regarding the rare but aggressive insular thyroid carcinoma (ITC), the value of prophylactic central compartment neck dissection (CCND) for clinically node-negative (cN0) disease is unclear. We aimed to provide the first evidence. Methods. N0 and pN1a ITC patients were identified from the Surveillance, Epidemiology, and End Results database. These patients were divided into thyroid-surgery + CCND group (pN0/pN1a patients confirmed by CCND) and thyroid-surgery group (cN0 patients without CCND). Differences in overall survival (OS) and disease-specific survival (DSS) between the two groups were evaluated. Subgroup analyses were also conducted. Results. Of the overall 112 patients, 44 (39.3%) received CCND. On multivariate analyses, the lobectomy ± isthmusectomy/total-thyroidectomy (Lob/TT) group demonstrated poorer OS and DSS than the Lob/TT + CCND group (P<0.05). When we separately analyzed patients treated by TT, multivariate analyses showed the TT group still revealed compromised OS and DSS than the TT + CCND group (P<0.05). Furthermore, absence of CCND independently predicted decreased OS no matter whether radioactive iodine (RAI) was administered. Similar results were obtained for T3/T4 patients. Moreover, for T1/T2 patients receiving CCND, 0/12 died during the study period, while for T1/T2 patients without CCND, 8/23 (34.8%) died, 5/23 (21.7%) due to ITC. Conclusion. Regardless of T staging and RAI treatment, cN0-ITC patients without CCND had decreased survival compared with pN0/pN1a patients receiving CCND. Therefore, if a cN0 patient is diagnosed with ITC, prophylactic CCND may be considered as a secondary procedure (postoperatively diagnosed) or a primary procedure (preoperatively/intraoperatively diagnosed). Prospective studies are expected to validate the conclusion.
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- 2019
4. A 4 Gene-based Immune Signature Predicts Dedifferentiation and Immune Exhaustion in Thyroid Cancer.
- Author
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Cui-Wei Li, Xiao Shi, Ben Ma, Yu-Long Wang, Zhong-Wu Lu, Tian Liao, Yu Wang, Qing-Hai Ji, Wen-Jun Wei, Li, Cui-Wei, Shi, Xiao, Ma, Ben, Wang, Yu-Long, Lu, Zhong-Wu, Liao, Tian, Wang, Yu, Ji, Qing-Hai, and Wei, Wen-Jun
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THYROID cancer ,IMMUNE checkpoint proteins - Abstract
Context: The role of immune-related genes (IRGs) in thyroid cancer dedifferentiation and accompanying immune exhaustion remains largely unexplored.Objective: To construct a significant IRG-based signature indicative of dedifferentiation and immune exhaustion in thyroid cancer.Design and Settings: One exploratory cohort and 2 validation cohorts were used to identify stably dysregulated IRGs in dedifferentiated thyroid cancer (DDTC) and to obtain independent risk factors for dedifferentiation. The IRGs formed a gene signature, whose predictive value was tested by the receiver operating characteristic curve. Correlations between the signature and differentiation-related genes, immune checkpoints, and prognosis were analyzed. Gene set enrichment analyses were performed to identify related signaling pathways.Results: Four IRGs (PRKCQ, PLAUR, PSMD2, and BMP7) were found to be repeatedly dysregulated in DDTC, and they formed an IRG-based signature with a satisfactory predictive value for thyroid cancer dedifferentiation. Correlation analyses revealed that immune checkpoints were closely related to the 4 IRGs and the IRG-based signature, which was significantly associated with the histological subtype (P = 0.026), lymph node metastasis (P = 0.001), and BRAFV600E mutation (P < 0.001). The downregulated expression of PRKCQ shortened the disease-free survival for patients with thyroid cancer. Furthermore, we identified several signaling pathways inherently associated with the IRG-based signature.Conclusions: This study suggests that IRGs participate in the dedifferentiation and immune exhaustion process of thyroid cancer and are potential biomarkers for DDTC. [ABSTRACT FROM AUTHOR]- Published
- 2021
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5. The origin of driving force for the formation of Sn whiskers at room temperature.
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Shi-Bo Li, Guo-Ping Bei, Hong-Xiang Zhai, Zhi-Li Zhang, Yang Zhou, and Cui-Wei Li
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METALLIC whiskers ,TIN ,METALLURGY ,AGGLOMERATION (Materials) ,OXIDATION ,POLYHEDRA - Abstract
Sn whiskers can form at room temperature on the agglomerated flakes produced by mechanical alloying (MA) of Ti, Sn, and C powders, whether the flakes are stored in air or water. The Sn whiskers forming in air are tens of micrometers to several centimeters in length and 0.5 to ~10 µm in diameter. Whereas a large amount of Sn polyhedra forms on the flakes that are stored in water, a small amount of Sn whiskers forms on the polyhedra. The driving force for Sn whisker formation is the compressive stress induced by mechanical alloying (MA) and oxidation. The mechanism about the spontaneous growth of metal whiskers is discussed. [ABSTRACT FROM AUTHOR]
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- 2007
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6. Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly.
- Author
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Liu L, Liu Y, Cui J, Liu H, Liu YB, Qiao WL, Sun H, and Yan CD
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- Adult, Age Factors, Aged, Aged, 80 and over, Aging pathology, Arterioles metabolism, Arterioles pathology, Arterioles physiopathology, Glutathione Peroxidase metabolism, Humans, Hydrogen Peroxide metabolism, Male, Malondialdehyde metabolism, Middle Aged, Superoxide Dismutase metabolism, Vasodilator Agents pharmacology, Xanthine Oxidase metabolism, Aging metabolism, Gastric Mucosa blood supply, Oxidative Stress, Vasodilation drug effects
- Abstract
Aim: To evaluate human gastric submucosal vascular dysfunction and its mechanism during the aging process., Methods: Twenty male patients undergoing subtotal gastrectomy were enrolled in this study. Young and elderly patient groups aged 25-40 years and 60-85 years, respectively, were included. Inclusion criteria were: no clinical evidence of cardiovascular, renal or diabetic diseases. Conventional clinical examinations were carried out. After surgery, gastric submucosal arteries were immediately dissected free of fat and connective tissue. Vascular responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were measured by isolated vascular perfusion. Morphological changes in the gastric mucosal vessels were observed by hematoxylin and eosin (HE) staining and Verhoeff van Gieson (EVG) staining. The expression of xanthine oxidase (XO) and manganese-superoxide dismutase (Mn-SOD) was assessed by Western blotting analysis. The malondialdehyde (MDA) and hydrogen peroxide (H₂O₂) content and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined according to commercial kits., Results: The overall structure of vessel walls was shown by HE and EVG staining, respectively. Disruption of the internal elastic lamina or neointimal layers was not observed in vessels from young or elderly patients; however, cell layer number in the vessel wall increased significantly in the elderly group. Compared with submucosal arteries in young patients, the amount of vascular collagen fibers, lumen diameter and media cross-sectional area were significantly increased in elderly patients. Ach- and SNP-induced vasodilatation in elderly arterioles was significantly decreased compared with that of gastric submucosal arterioles from young patients. Compared with the young group, the expression of XO and the contents of MDA and H₂O₂ in gastric submucosal arterioles were increased in the elderly group. In addition, the expression of Mn-SOD and the activities of SOD and GSH-Px in the elderly group decreased significantly compared with those in the young group., Conclusion: Gastric vascular dysfunction and senescence may be associated with increased oxidative stress and decreased antioxidative defense in the aging process.
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- 2013
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7. Opening of tartrate acetals using dialkylboron bromide: evidence for stereoselectivity downstream from ring fission.
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Guindon Y, Ogilvie WW, Bordeleau J, Cui WL, Durkin K, Gorys V, Juteau H, Lemieux R, Liotta D, Simoneau B, and Yoakim C
- Abstract
Johnson-type acetals derived from dimethyl tartrate give, after opening with Me(2)BBr and cuprate displacement, secondary alcohols with high diastereoselectivity (>30:1). The mechanism proposed for the induction of diastereoselectivity is downstream from the ring fission. It implies a direct participation of the Lewis acid as a source of nucleophile and the stereospecific transformation of the resulting bromo acetal through an invertive and temperature-dependent process. The acetals are prepared by reaction of the desired aldehyde with dimethyl tartrate. Removal of the auxiliary is accomplished through SmI(2) reduction or by an addition-elimination protocol using methoxide.
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- 2003
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