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Ultrasound‐generated antigens combined with TLR7/8 agonists as adjuvants have demonstrated significant anti‐tumor efficacy as an in‐situ vaccine. However, the use of TLR7/8 agonists can cause severe inflammatory responses. In this study, we present a novel tumor‐targeting nano‐adjuvant termed aPDL1‐PLG/R848 NPs, which are composed of aPDL1 antibody, Fc‐III‐4C peptide linker (Fc‐linker) and poly(L‐glutamic acid)‐grafted‐R848. Under ultrasound irradiation, antigen‐presenting cells activate immune mechanisms in vivo under dual stimulation of in situ antigens and immune adjuvants. The strategy inhibits primary tumor growth and induces a strong antigen‐specific immune memory effect to prevent tumor recurrence in vivo. This work offers a safe and potent platform for an in situ cancer vaccine based on ultrasound therapy. [ABSTRACT FROM AUTHOR]

As the esports industry experiences unprecedented growth, efforts to legitimize it as a recognized sport have intensified. This paper explores the transformative changes in China's esports landscape with focus on the aftermath of its official recognition at the 2023 Asian Games in Hangzhou. For this, this study employs a data-driven comparative approach to analyze both online news data and viewer comments on a video platform broadcasting the esports tournament during the Hangzhou Asian Games. For text data, it utilized text mining techniques of the Latent Dirichlet Allocation algorithm (LDA), and for conversion from image to text, it used through the Contrastive Language–Image Pretraining (CLIP) model. The findings reveal that the text and image data in online news emphasize the industry's positive anticipation of esports becoming a medal sport, but the public who watched esports events showed mixed expectations, doubts, or even negative sentiments about the reevaluation of esports. As evidenced in the paper, the public's divided stance towards esports might hinder the establishment of a solid consensus in developing the necessary infrastructure or policymaking. Thus, the transition for games to be recognized as an Olympic sport after their inclusion in the Asian Games demands a prolonged period and a comprehensive blend of economic, social, cultural, and educational policies. [ABSTRACT FROM AUTHOR]