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296 results on '"Cui, HuiRu"'

35. Models of mild cognitive deficits in risk assessment in early psychosis.

Author

Zhang, TianHong, Cui, HuiRu, Tang, XiaoChen, Xu, LiHua, Wei, YanYan, Hu, YeGang, Tang, YingYing, Wang, ZiXuan, Liu, HaiChun, Chen, Tao, Li, ChunBo, and Wang, JiJun

Subjects
*COMPETENCY assessment (Law), *COGNITION disorders diagnosis, *COGNITION disorder risk factors, *RISK assessment, *CONSENSUS (Social sciences), *PREDICTION models, *RECEIVER operating characteristic curves, *DESCRIPTIVE statistics, *COGNITION disorders, *NEUROPSYCHOLOGICAL tests, *MEMORY, *PSYCHOSES, *EARLY diagnosis, *COMPARATIVE studies, *COGNITION
Abstract

Background: Mild cognitive deficits (MCD) emerge before the first episode of psychosis (FEP) and persist in the clinical high-risk (CHR) stage. This study aims to refine risk prediction by developing MCD models optimized for specific early psychosis stages and target populations. Methods: A comprehensive neuropsychological battery assessed 1059 individuals with FEP, 794 CHR, and 774 matched healthy controls (HCs). CHR subjects, followed up for 2 years, were categorized into converters (CHR-C) and non-converters (CHR-NC). The MATRICS Consensus Cognitive Battery standardized neurocognitive tests were employed. Results: Both the CHR and FEP groups exhibited significantly poorer performance compared to the HC group across all neurocognitive tests (all p < 0.001). The CHR-C group demonstrated poorer performance compared to the CHR-NC group on three sub-tests: visuospatial memory (p < 0.001), mazes (p = 0.005), and symbol coding (p = 0.023) tests. Upon adjusting for sex and age, the performance of the MCD model was excellent in differentiating FEP from HC, as evidenced by an Area Under the Receiver Operating Characteristic Curve (AUC) of 0.895 (p < 0.001). However, when applied in the CHR group for predicting CHR-C (AUC = 0.581, p = 0.008), the performance was not satisfactory. To optimize the efficiency of psychotic risk assessment, three distinct MCD models were developed to distinguish FEP from HC, predict CHR-C from CHR-NC, and identify CHR from HC, achieving accuracies of 89.3%, 65.6%, and 80.2%, respectively. Conclusions: The MCD exhibits variations in domains, patterns, and weights across different stages of early psychosis and diverse target populations. Emphasizing precise risk assessment, our findings highlight the importance of tailored MCD models for different stages and risk levels. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Spatial and Temporal Abnormalities of Spontaneous Fixational Saccades and Their Correlates With Positive and Cognitive Symptoms in Schizophrenia.

Author

Liu, Xu, Li, Yu, Xu, Lihua, Zhang, Tianhong, Cui, Huiru, Wei, Yanyan, Xia, Mengqing, Su, Wenjun, Tang, Yingying, Tang, Xiaochen, Zhang, Dan, Spillmann, Lothar, Andolina, Ian Max, McLoughlin, Niall, Wang, Wei, and Wang, Jijun

Subjects
COGNITION disorders, BIOMARKERS, SACCADIC eye movements, EYE movements, SCHIZOPHRENIA, DESCRIPTIVE statistics, RESEARCH funding, SPACE perception
Abstract

Background and Hypothesis Visual fixation is a dynamic process, with the spontaneous occurrence of microsaccades and macrosaccades. These fixational saccades are sensitive to the structural and functional alterations of the cortical-subcortical-cerebellar circuit. Given that dysfunctional cortical-subcortical-cerebellar circuit contributes to cognitive and behavioral impairments in schizophrenia, we hypothesized that patients with schizophrenia would exhibit abnormal fixational saccades and these abnormalities would be associated with the clinical manifestations. Study Design Saccades were recorded from 140 drug-naïve patients with first-episode schizophrenia and 160 age-matched healthy controls during ten separate trials of 6-second steady fixations. Positive and negative symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Study Results Patients with schizophrenia exhibited fixational saccades more vertically than controls, which was reflected in more vertical saccades with angles around 90° and a greater vertical shift of horizontal saccades with angles around 0° in patients. The fixational saccades, especially horizontal saccades, showed longer durations, faster peak velocities, and larger amplitudes in patients. Furthermore, the greater vertical shift of horizontal saccades was associated with higher PANSS total and positive symptom scores in patients, and the longer duration of horizontal saccades was associated with lower MCCB neurocognitive composite, attention/vigilance, and speed of processing scores. Finally, based solely on these fixational eye movements, a K-nearest neighbors model classified patients with an accuracy of 85%. Conclusions: Our results reveal spatial and temporal abnormalities of fixational saccades and suggest fixational saccades as a promising biomarker for cognitive and positive symptoms and for diagnosis of schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Serum angioneurin levels following electroconvulsive therapy for mood disorders.

Author

Zhang, TianHong, Tang, XiaoChen, Wei, YanYan, Xu, LiHua, Hu, YeGang, Cui, HuiRu, Zeng, JiaHui, Ye, JiaYi, Xie, YuOu, Tang, YingYing, Liu, HaiChun, Chen, Tao, Li, ChunBo, Liu, XiaoHua, and Wang, JiJun

Subjects
ELECTROCONVULSIVE therapy, AFFECTIVE disorders, VASCULAR endothelial growth factors, NERVE growth factor, MENTAL depression, CATATONIA
Abstract

Objectives: The efficacy of electroconvulsive therapy (ECT) in treating mood disorders (MDs) is hypothesized to be mediated by the induction of neurotrophic factors (denoted "angioneurins") that trigger neuronal plasticity. This study aimed to assess the effects of ECT on serum angioneurin levels in patients with MD. Methods: A total of 110 patients with MDs including 30 with unipolar depression, 25 with bipolar depression (BD), 55 with bipolar mania (BM), and 50 healthy controls were included in the study. Patients were subdivided into two groups: those who received ECT + medication (12 ECT sessions) and those who received only medication (no‐ECT). Depressive and manic symptom assessments and measurements of vascular endothelial growth factor (VEGF), fibroblast growth factor‐2, nerve growth factor (NGF), and insulin‐like growth factor‐1 levels in blood samples were performed at baseline and week 8. Results: Patients in the ECT group, specifically those with BD and BM, had significantly increased levels of VEGF compared to their baseline VEGF levels (p = 0.002). No significant changes in angioneurin levels were observed in the no‐ECT group. Serum NGF levels were significantly associated with a reduction in depressive symptoms. Angioneurin levels were not associated with manic symptom reduction. Conclusions: This study hints that ECT may increase VEGF levels with angiogenic mechanisms that amplify NGF signaling to promote neurogenesis. It may also contribute to changes in brain function and emotional regulation. However, further animal experiments and clinical validation are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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