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226 results on '"Crema, Michel D."'

9. The DIGICOD cohort: A hospital-based observational prospective cohort of patients with hand osteoarthritis – methodology and baseline characteristics of the population

Author

Sellam, Jérémie, Maheu, Emmanuel, Crema, Michel D., Touati, Amel, Courties, Alice, Tuffet, Sophie, Rousseau, Alexandra, Chevalier, Xavier, Combe, Bernard, Dougados, Maxime, Fautrel, Bruno, Kloppenburg, Margreet, Laredo, Jean-Denis, Loeuille, Damien, Miquel, Anne, Rannou, François, Richette, Pascal, Simon, Tabassome, and Berenbaum, Francis

Published
2021
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11. Intra‐Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study.

Author

Liew, Jean W., Jarraya, Mohammed, Guermazi, Ali, Lynch, John, Felson, David, Nevitt, Michael, Lewis, Cora E., Torner, James, Roemer, Frank W., Crema, Michel D., Wang, Na, Becce, Fabio, Rabasa, Gabriela, Pascart, Tristan, and Neogi, Tuhina

Subjects
KNEE radiography, CALCIUM metabolism, KNEE osteoarthritis, RISK assessment, INDEPENDENT living, BODY mass index, TISSUES, ARTICULAR cartilage, RESEARCH funding, COMPUTED tomography, RESEARCH evaluation, MAGNETIC resonance imaging, DESCRIPTIVE statistics, KNEE joint, LONGITUDINAL method, ARTICULAR cartilage injuries, CHONDROCALCINOSIS, CONFIDENCE intervals, DISEASE risk factors, OLD age
Abstract

Objective: Intra‐articular (IA) mineralization may contribute to osteoarthritis (OA) structural progression. We studied the association of IA mineralization on knee computed tomography (CT) with cartilage damage worsening on knee magnetic resonance imaging (MRI), with a focus on location‐ and tissue‐specific effects. Methods: Participants from the Multicenter Osteoarthritis Study with knee CT and MRI scans were included. Presence of IA mineralization on CT was defined as a Boston University Calcium Knee Score >0 anywhere in the knee. Cartilage worsening on MRI was defined as any increase in the MRI OA Knee Score, including incident damage. We evaluated the association of whole‐knee, compartment‐specific (ie, medial or lateral), and subregion‐specific (ie, location‐matched) IA mineralization at baseline with cartilage worsening at two years' follow‐up in the corresponding locations using binomial regression with generalized estimating equations, adjusting for age, sex, and body mass index (BMI). Results: We included 1,673 participants (mean age 60 years, 56% female, mean BMI 29). Nine percent had any IA mineralization in the knee, and 47.4% had any cartilage worsening on follow‐up. Mineralization of any tissue in the knee, regardless of location, was not associated with MRI cartilage worsening. However, cartilage mineralization was associated with 1.39 (95% confidence interval 1.04–1.88) times higher risk of cartilage worsening in the same compartment, with similar results in subregion‐specific analysis. Conclusion: CT‐detected IA mineralization in the cartilage was associated with higher risk of MRI cartilage worsening in the same compartment and subregion over two years. These findings suggest potential localized, tissue‐specific effects of IA mineralization on cartilage pathology in knee OA. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Role of imaging for eligibility and safety of a-NGF clinical trials.

Author

Roemer, Frank W., Hochberg, Marc C., Carrino, John A., Kompel, Andrew J., Diaz, Luis, Hayashi, Daichi, Crema, Michel D., and Guermazi, Ali

Abstract

Nerve growth factor (a-NGF) inhibitors have been developed for pain treatment including symptomatic osteoarthritis (OA) and have proven analgesic efficacy and improvement in functional outcomes in patients with OA. However, despite initial promising data, a-NGF clinical trials focusing on OA treatment had been suspended in 2010. Reasons were based on concerns regarding accelerated OA progression but were resumed in 2015 including detailed safety mitigation based on imaging. In 2021, an FDA advisory committee voted against approving tanezumab (one of the a-NGF compounds being evaluated) and declared that the risk evaluation and mitigation strategy was not sufficient to mitigate potential safety risks. Future clinical trials evaluating the efficacy of a-NGF or comparable molecules will need to define strict eligibility criteria and will have to include strategies to monitor safety closely. While disease-modifying effects are not the focus of a-NGF treatments, imaging plays an important role to evaluate eligibility of potential participants and to monitor safety during the course of these studies. Aim is to identify subjects with on-going safety findings at the time of inclusion, define those potential participants that are at increased risk for accelerated OA progression and to withdraw subjects from on-going studies in a timely fashion that exhibit imaging-confirmed structural safety events such as rapid progressive OA. OA efficacy- and a-NGF studies apply imaging for different purposes. In OA efficacy trials image acquisition and evaluation aims at maximizing sensitivity in order to capture structural effects between treated and non-treated participants in longitudinal fashion. In contrast, the aim of imaging in a-NGF trials is to enable detection of structural tissue alterations that either increase the risk of a negative outcome (eligibility) or may result in termination of treatment (safety). [ABSTRACT FROM AUTHOR]

Published
2023
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23. Strategic application of imaging in DMOAD clinical trials: focus on eligibility, drug delivery, and semiquantitative assessment of structural progression.

Author

Guermazi, Ali, Roemer, Frank W., Crema, Michel D., Jarraya, Mohamed, Mobasheri, Ali, and Hayashi, Daichi

Abstract

Despite decades of research efforts and multiple clinical trials aimed at discovering efficacious disease-modifying osteoarthritis (OA) drugs (DMOAD), we still do not have a drug that shows convincing scientific evidence to be approved as an effective DMOAD. It has been suggested these DMOAD clinical trials were in part unsuccessful since eligibility criteria and imaging-based outcome evaluation were solely based on conventional radiography. The OA research community has been aware of the limitations of conventional radiography being used as a primary imaging modality for eligibility and efficacy assessment in DMOAD trials. An imaging modality for DMOAD trials should be able to depict soft tissue and osseous pathologies that are relevant to OA disease progression and clinical manifestations of OA. Magnetic resonance imaging (MRI) fulfills these criteria and advances in technology and increasing knowledge regarding imaging outcomes likely should play a more prominent role in DMOAD clinical trials. In this perspective article, we will describe MRI-based tools and analytic methods that can be applied to DMOAD clinical trials with a particular emphasis on knee OA. MRI should be the modality of choice for eligibility screening and outcome assessment. Optimal MRI pulse sequences must be chosen to visualize specific features of OA. [ABSTRACT FROM AUTHOR]

Published
2023
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40. LB-003 - Serum Intestinal Permeability Biomarkers are associated with erosive hand osteoarthritis and radiographic severity: Results: from the DIGICOD cohort.

Author

Binvignat, Marie, Fellahi, Soraya, Bastard, Jean-Philippe, Rousseau, Alexandra, Tuffet, Sophie, Courties, Alice, Pigenet, Audrey, WANHERDRICK, Kristell, Kloppenburg, Margreet, Richette, Pascal, Maheu, Emmanuel, Crema, Michel D., Klatzmann, David, Sokol, Harry, Mariotti-Ferrandiz, Encarnita, Berenbaum, Francis, and Sellam, Jeremie

Published
2024
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48. Partial- and Full-thickness focal cartilage defects equally contribute to development of new cartilage damage in knee osteoarthritis - the Multicenter Osteoarthritis Study

Author

Guermazi, Ali, Hayashi, Daichi, Roemer, Frank W., Niu, Jingbo, Quinn, Emily K., Crema, Michel D., Nevitt, Michael C., Torner, James, Lewis, Cora E., and Felson, David T.

Subjects
Cartilage, Articular, Male, Disease Progression, Humans, Female, Prospective Studies, Middle Aged, Osteoarthritis, Knee, Risk Assessment, Article, Aged, Follow-Up Studies
Abstract

To determine the risk of incident cartilage damage at follow-up in subregions that are undamaged at baseline, by comparing tibiofemoral joint compartments with a baseline focal partial-thickness or full-thickness cartilage defect against compartments without any baseline cartilage damage, in knees with and those without radiographic osteoarthritis (OA).We included participants in the Multicenter Osteoarthritis Study for whom there were semiquantitative magnetic resonance imaging readings at baseline and at 30 months. We estimated the risk of incident cartilage defects developing in tibiofemoral compartments with prevalent partial-thickness and full-thickness cartilage defects in only one subregion within the compartment, using tibiofemoral compartments with no baseline cartilage defects as a referent. Logistic regression with generalized estimating equations was used for all analyses, with adjustments for confounders.A total of 374 compartments (359 knees) were included, and 140 knees (39%) had radiographic OA. Compared to compartments with no baseline cartilage defects, those with partial-thickness (adjusted odds ratio 1.62 [95% confidence interval 1.06-2.47]) and full-thickness (adjusted odds ratio 1.92 [95% confidence interval 1.00-3.66]) cartilage defects in a subregion had a higher risk of incident cartilage defects in other subregions in the same compartment.Prevalent focal cartilage defects, regardless of defect depth, in a single subregion within a tibiofemoral joint compartment increase the risk of developing new cartilage damage in other subregions of the same compartment for middle-aged to elderly persons with or at high risk of knee OA.

Published
2017

50. Imaging of Gymnastics Injuries

Author

Nusman, Charlotte M., van Braak, Willemieke G., Kox, Laura S., Kerkhoffs, Gino M. M. J., Maas, Mario, Guermazi, Ali, Roemer, Frank W., Crema, Michel D., Radiology and Nuclear Medicine, Amsterdam Movement Sciences, Graduate School, and Amsterdam Gastroenterology Endocrinology Metabolism

Published
2016

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