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5. Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity

Author

Brambilla, Marta, Becchetti, Alessia, Rovati, Gian Enrico, Cosentino, Nicola, Conti, Maria, Canzano, Paola, Giesen, Peter L.A., Loffreda, Alessia, Bonomi, Alice, Cattaneo, Marco, De Candia, Erica, Podda, Gian Marco, Trabattoni, Daniela, Werba, Pablo Josè, Campodonico, Jeness, Pinna, Christian, Marenzi, Giancarlo, Tremoli, Elena, and Camera, Marina

Published
2023
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11. Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients

Author

Canzano, Paola, Brambilla, Marta, Porro, Benedetta, Cosentino, Nicola, Tortorici, Elena, Vicini, Stefano, Poggio, Paolo, Cascella, Andrea, Pengo, Martino F., Veglia, Fabrizio, Fiorelli, Susanna, Bonomi, Alice, Cavalca, Viviana, Trabattoni, Daniela, Andreini, Daniele, Omodeo Salè, Emanuela, Parati, Gianfranco, Tremoli, Elena, and Camera, Marina

Published
2021
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12. Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function.

Author

Falcão‐Pires, Inês, Ferreira, Ana Filipa, Trindade, Fábio, Bertrand, Luc, Ciccarelli, Michele, Visco, Valeria, Dawson, Dana, Hamdani, Nazha, Van Laake, Linda W., Lezoualc'h, Frank, Linke, Wolfgang A., Lunde, Ida G, Rainer, Peter P., Abdellatif, Mahmoud, Van der Velden, Jolanda, Cosentino, Nicola, Paldino, Alessia, Pompilio, Giulio, Zacchigna, Serena, and Heymans, Stephane

Subjects
DIASTOLE (Cardiac cycle), SODIUM-glucose cotransporter 2 inhibitors, CORONARY artery bypass, CARDIAC pacing, HEART assist devices, CARDIOVASCULAR diseases, RENIN-angiotensin system
Abstract

Cardiovascular disease (CVD) is the leading cause of morbimortality in Europe and worldwide. CVD imposes a heterogeneous spectrum of cardiac remodelling, depending on the insult nature, that is, pressure or volume overload, ischaemia, arrhythmias, infection, pathogenic gene variant, or cardiotoxicity. Moreover, the progression of CVD‐induced remodelling is influenced by sex, age, genetic background and comorbidities, impacting patients' outcomes and prognosis. Cardiac reverse remodelling (RR) is defined as any normative improvement in cardiac geometry and function, driven by therapeutic interventions and rarely occurring spontaneously. While RR is the outcome desired for most CVD treatments, they often only slow/halt its progression or modify risk factors, calling for novel and more timely RR approaches. Interventions triggering RR depend on the myocardial insult and include drugs (renin–angiotensin–aldosterone system inhibitors, beta‐blockers, diuretics and sodium–glucose cotransporter 2 inhibitors), devices (cardiac resynchronization therapy, ventricular assist devices), surgeries (valve replacement, coronary artery bypass graft), or physiological responses (deconditioning, postpartum). Subsequently, cardiac RR is inferred from the degree of normalization of left ventricular mass, ejection fraction and end‐diastolic/end‐systolic volumes, whose extent often correlates with patients' prognosis. However, strategies aimed at achieving sustained cardiac improvement, predictive models assessing the extent of RR, or even clinical endpoints that allow for distinguishing complete from incomplete RR or adverse remodelling objectively, remain limited and controversial. This scientific statement aims to define RR, clarify its underlying (patho)physiologic mechanisms and address (non)pharmacological options and promising strategies to promote RR, focusing on the left heart. We highlight the predictors of the extent of RR and review the prognostic significance/impact of incomplete RR/adverse remodelling. Lastly, we present an overview of RR animal models and potential future strategies under pre‐clinical evaluation. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Chapter Three - Vitamin D and cardiovascular diseases.

Author

Milazzo, Valentina, Cosentino, Nicola, Trombara, Filippo, and Marenzi, Giancarlo

Abstract

Vitamin D has an established role in calcium homeostasis but its deficiency is emerging also as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and several cardiovascular risk factors and major CVDs, such as coronary artery disease, heart failure, and cardiac arrhythmias. In all these clinical settings, vitamin D deficiency seems to predispose to increased morbidity, mortality, and recurrent cardiovascular events. Despite this growing evidence, interventional trials with supplementation of vitamin D in patients at risk of or with established CVD are still controversial. In this chapter, we summarize the currently available evidence on the links between vitamin D deficiency and major cardiovascular risk factors and CVD, in terms of both clinical relevance and potential therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Renal replacement therapy in patients with acute myocardial infarction: Rate of use, clinical predictors and relationship with in-hospital mortality

Author

Marenzi, Giancarlo, Cosentino, Nicola, Marinetti, Andrea, Leone, Antonio M., Milazzo, Valentina, Rubino, Mara, De Metrio, Monica, Cabiati, Angelo, Campodonico, Jeness, Moltrasio, Marco, Bertoli, Silvio, Cecere, Milena, Mosca, Susanna, Marana, Ivana, Grazi, Marco, Lauri, Gianfranco, Bonomi, Alice, Veglia, Fabrizio, and Bartorelli, Antonio L

Published
2017
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15. Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and without diabetes mellitus

Author

Lucci, Claudia, Cosentino, Nicola, Genovese, Stefano, Campodonico, Jeness, Milazzo, Valentina, De Metrio, Monica, Rondinelli, Maurizio, Riggio, Daniela, Biondi, Maria Luisa, Rubino, Mara, Celentano, Katia, Bonomi, Alice, Capra, Nicolò, Veglia, Fabrizio, Agostoni, Piergiuseppe, Bartorelli, Antonio L., and Marenzi, Giancarlo

Published
2020
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22. Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity.

Author

Brambilla, Marta, Becchetti, Alessia, Rovati, Gian Enrico, Cosentino, Nicola, Conti, Maria, Canzano, Paola, Giesen, Peter L. A., Loffreda, Alessia, Bonomi, Alice, Cattaneo, Marco, De Candia, Erica, Podda, Gian Marco, Trabattoni, Daniela, Josè Werba, Pablo, Campodonico, Jeness, Pinna, Christian, Marenzi, Giancarlo, Tremoli, Elena, and Camera, Marina

Published
2023
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23. Prognostic Impact of Percutaneous Coronary Intervention in Older Patients Hospitalized with Acute Myocardial Infarction: Real-World Findings from the Lombardy Health Database.

Author

Marenzi, Giancarlo, Cosentino, Nicola, Resta, Marta, Lucci, Claudia, Bonomi, Alice, Trombara, Filippo, Della Rocca, Michele, Poggio, Paolo, Leoni, Olivia, Bortolan, Francesco, Savonitto, Stefano, and Agostoni, Piergiuseppe

Subjects
*MYOCARDIAL infarction, *PERCUTANEOUS coronary intervention, *OLDER patients, *DATABASES, *HOSPITAL mortality
Abstract

Background. Older patients are less likely to receive percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) compared to younger patients. We investigated the prognostic impact of PCI in a large population of patients hospitalized with AMI in the period 2003–2018 by using the administrative Lombardy Health Database (Italy). Methods. We considered all patients aged ≥75 years hospitalized with AMI (either STEMI or NSTEMI) from 2003 to 2018 in Lombardy. Patients were grouped according to whether they were treated or not with PCI during the index hospitalization. The primary outcome was in-hospital mortality. The secondary endpoints were 1-year mortality and 1-year re-hospitalization for acute heart failure (AHF) or AMI. Results. 116,063 patients aged ≥75 years (mean age 83 ± 6; 48% males; 46% STEMI) were hospitalized with a primary diagnosis of AMI. Thirty-seven percent of them (n = 42,912) underwent PCI. The in-hospital mortality rate was significantly lower in PCI-treated patients (6% vs. 15%; p < 0.0001). One-year mortality and 1-year re-hospitalization for AHF/AMI were less frequent in PCI-treated patients (16% vs. 41% and 15% vs. 21%, respectively; p < 0.0001). The adjusted risks of the study endpoints were lower in PCI-treated patients: OR 0.37 (95% CI 0.36–0.39) for in-hospital mortality; HR 0.37 (95% CI 0.36–0.38) for 1-year mortality; HR 0.74 (95% CI 0.71–0.77) for 1-year re-hospitalization for AHF/AMI. Similar results were found in STEMI and NSTEMI patients considered separately. Conclusions. Our real-world data showed that in patients with AMI ≥ 75 years of age, PCI use is associated with lower in-hospital and 1-year mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Impact of Accuracy of Fractional Flow Reserve to Reduction of Microvascular Resistance After Intracoronary Adenosine in Patients With Angina Pectoris or Non–ST-Segment Elevation Myocardial Infarction

Author

Niccoli, Giampaolo, Falcioni, Elena, Cosentino, Nicola, Fracassi, Francesco, Roberto, Marco, Fabretti, Alessandro, Panebianco, Mario, Scalone, Giancarla, Burzotta, Francesco, Trani, Carlo, Leone, Antonio Maria, Davies, Justin, and Crea, Filippo

Published
2014
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27. Prognostic Stratification of Patients With ST-Segment–Elevation Myocardial Infarction (PROSPECT): A Cardiac Magnetic Resonance Study

Author

Pontone, Gianluca, Guaricci, Andrea I., Andreini, Daniele, Ferro, Giovanni, Guglielmo, Marco, Baggiano, Andrea, Fusini, Laura, Muscogiuri, Giuseppe, Lorenzoni, Valentina, Mushtaq, Saima, Conte, Edoardo, Annoni, Andrea, Formenti, Alberto, Mancini, Maria Elisabetta, Carità, Patrizia, Verdecchia, Massimo, Pica, Silvia, Fazzari, Fabio, Cosentino, Nicola, Marenzi, Giancarlo, Rabbat, Mark G., Agostoni, Piergiuseppe, Bartorelli, Antonio L., Pepi, Mauro, and Masci, Pier Giorgio

Published
2017
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28. Prognostic Impact of Percutaneous Coronary Intervention in Chronic Dialysis Patients with Acute Myocardial Infarction: Findings from the Lombardy Health Database.

Author

Cosentino, Nicola, Genovesi, Simonetta, Bonomi, Alice, Trombara, Filippo, Ludergnani, Monica, Leoni, Olivia, Bortolan, Francesco, Agostoni, Piergiuseppe, and Marenzi, Giancarlo

Abstract

Background: Patients on chronic dialysis are less likely to be treated with percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). This is due to the lack of evidence from randomized trials, concerns about possible PCI-related side effects, and multimorbidity. Therefore, routine use of PCI for treatment of dialysis patients with AMI remains an unresolved issue. Methods: We analyzed data of patients on chronic dialysis hospitalized with AMI from 2003 to 2018, by using the administrative Lombardy Health Database (Italy). Patients were grouped according to whether they underwent or not PCI during index hospitalization. The primary outcome was in-hospital mortality, 1-year mortality was the secondary endpoint. Results: During the study period, 265,048 patients were hospitalized with AMI. Of them, 3206 (1.2%) were on chronic dialysis (age 71 ± 11; 72% males). Among dialysis patients, 44% underwent PCI, while 54% underwent PCI among non-dialysis patients (p < 0.0001). Dialysis was an independent predictor of treatment with medical therapy only (OR 0.75 [95% CI 0.70-0.81]). In-hospital mortality in the dialysis cohort was 15%, significantly lower in patients treated with PCI than in those not treated with PCI (11% vs. 19%; p < 0.0001). One-year mortality was 47% and it was lower in PCI-treated patients (33% vs. 52%; p < 0.0001). The adjusted risk of the study endpoints was significantly lower in dialysis patients undergoing PCI: OR 0.62 (95% CI 0.50-0.76) for in-hospital mortality; HR 0.63 (95% CI 0.56-0.71) for 1-year mortality. Conclusions: This study showed that in AMI patients on chronic dialysis, PCI is associated with a significant in-hospital and 1-year survival benefit. Yet, they underwent PCI less frequently than patients with preserved renal function. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Open-Label, Randomized, Placebo-Controlled Evaluation of Intracoronary Adenosine or Nitroprusside After Thrombus Aspiration During Primary Percutaneous Coronary Intervention for the Prevention of Microvascular Obstruction in Acute Myocardial Infarction: The REOPEN-AMI Study (Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction)

Author

Niccoli, Giampaolo, Rigattieri, Stefano, De Vita, Maria Rosaria, Valgimigli, Marco, Corvo, Pierfrancesco, Fabbiocchi, Franco, Romagnoli, Enrico, De Caterina, Alberto Ranieri, La Torre, Giuseppe, Lo Schiavo, Paolo, Tarantino, Fabio, Ferrari, Roberto, Tomai, Fabrizio, Olivares, Paolo, Cosentino, Nicola, D'Amario, Domenico, Leone, Antonio Maria, Porto, Italo, Burzotta, Francesco, Trani, Carlo, and Crea, Filippo

Published
2013
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33. Effects of Drospirenone–Ethinylestradiol and/or Metformin on CD4+CD28null T Lymphocytes Frequency in Women With Hyperinsulinemia Having Polycystic Ovary Syndrome: A Randomized Clinical Trial

Author

Moro, Francesca, Morciano, Andrea, Tropea, Anna, Sagnella, Francesca, Palla, Carola, Scarinci, Elisa, Ciardulli, Andrea, Martinez, Daniela, Familiari, Alessandra, Liuzzo, Giovanna, Tritarelli, Alessandra, Cosentino, Nicola, Niccoli, Giampaolo, Crea, Filippo, Lanzone, Antonio, and Apa, Rosanna

Published
2013
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40. Impact of Prior Statin Therapy on In-Hospital Outcome of STEMI Patients Treated with Primary Percutaneous Coronary Intervention.

Author

Lanza, Oreste, Cosentino, Nicola, Lucci, Claudia, Resta, Marta, Rubino, Mara, Milazzo, Valentina, De Metrio, Monica, Trombara, Filippo, Campodonico, Jeness, Werba, José Pablo, Bonomi, Alice, and Marenzi, Giancarlo

Subjects
*MYOCARDIAL infarction, *PERCUTANEOUS coronary intervention, *STATINS (Cardiovascular agents), *ST elevation myocardial infarction, *CARDIOGENIC shock, *TREATMENT effectiveness
Abstract

Background: Prior statin therapy has a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We retrospectively evaluated the effect of prior statin therapy on in-hospital clinical outcomes in consecutive STEMI patients undergoing primary PCI. Methods: A total of 1790 patients (mean age 67 ± 11 years, 1354 men) were included. At admission, all patients were interrogated about prior (>6 months) statin therapy. The primary endpoint of the study was the composite of in-hospital mortality, acute pulmonary edema, and cardiogenic shock in patients with or without prior statin therapy. Results: A total of 427 patients (24%) were on prior statin therapy. The incidence of the primary endpoint was similar in patients with or without prior statin therapy (15% vs. 16%; p = 0.38). However, at multivariate analysis, prior statin therapy was associated with a lower risk of the primary endpoint, after adjustment for major prognostic predictors (odds ratio 0.61 [95% CI 0.39–0.96]; p = 0.03). Conclusions: This study demonstrated that prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI compared to those without prior statin therapy. [ABSTRACT FROM AUTHOR]

Published
2022
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