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2. First interim results from FINE-REAL: a prospective, non-interventional, phase 4 study providing insights into the use and safety of finerenone in a routine clinical setting

Author

Nicholas, Susanne B., Correa-Rotter, Ricardo, Desai, Nihar R., Guo, Lixin, Navaneethan, Sankar D., Pantalone, Kevin M., Wanner, Christoph, Hamacher, Stefanie, Fatoba, Samuel T., Horvat-Broecker, Andrea, Garreta-Rufas, Antonio, Gay, Alain, Merz, Martin, and Wheeler, David C.

Published
2024
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3. Mind the gap in kidney care: translating what we know into what we do

Author

Luyckx, Valerie A., Tuttle, Katherine R., Abdellatif, Dina, Correa-Rotter, Ricardo, Fung, Winston W. S., Haris, Agnès, Hsiao, Li-Li, Khalife, Makram, Kumaraswami, Latha A., Loud, Fiona, Raghavan, Vasundhara, Roumeliotis, Stefanos, Sierra, Marianella, Ulasi, Ifeoma, Wang, Bill, Lui, Siu-Fai, Liakopoulos, Vassilios, and Balducci, Alessandro

Published
2024
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6. Long-term effects of hypercalcemia in kidney transplant recipients with persistent hyperparathyroidism

Author

Ramirez-Sandoval, Juan Carlos, Marino, Lluvia, Cojuc-Konigsberg, Gabriel, Reul-Linares, Estefania, Pichardo-Cabrera, Nathalie Desire, Cruz, Cristino, Hernández-Paredes, Elisa Naomi, Berman-Parks, Nathan, Vidal-Ruíz, Vanessa, Estrada-Linares, Jonathan Mauricio, Reza-Albarrán, Alfredo Adolfo, Correa-Rotter, Ricardo, and Morales-Buenrostro, Luis Eduardo

Published
2023
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14. Effect of SGLT2 Inhibitors on Discontinuation of Renin–angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD Trials

Author

Fletcher, Robert A., Jongs, Niels, Chertow, Glenn M., McMurray, John J.V., Arnott, Clare, Jardine, Meg J., Mahaffey, Kenneth W., Perkovic, Vlado, Rockenschaub, Patrick, Rossing, Peter, Correa-Rotter, Ricardo, Toto, Robert D., Vaduganathan, Muthiah, Wheeler, David C., Heerspink, Hiddo J.L., and Neuen, Brendon L.

Published
2023
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20. Mind the Gap in Kidney Care: Translating What We Know Into What We Do.

Author

Luyckx, Valerie A, Tuttle, Katherine R, Abdellatif, Dina, Correa-Rotter, Ricardo, Fung, Winston W S, Haris, Agnès, Hsiao, Li-Li, Khalife, Makram, Kumaraswami, Latha A, Loud, Fiona, Raghavan, Vasundhara, Roumeliotis, Stefanos, Sierra, Marianella, Ulasi, Ifeoma, Wang, Bill, Lui, Siu-Fai, Liakopoulos, Vassilios, and Balducci;, Alessandro

Subjects
HEART failure, NON-communicable diseases, RENAL osteodystrophy, NEPHROLOGISTS, MEDICAL personnel, MANAGEMENT of electronic health records
Abstract

The article discusses the global burden of kidney disease and the gaps in kidney care, particularly in low- and middle-income countries. It highlights the high death rates and economic burden associated with chronic kidney disease (CKD) and the disparities in prevention, early detection, diagnosis, and treatment. The text emphasizes the importance of integrating kidney care into national non-communicable disease strategies and strengthening health systems. It also discusses the challenges in managing CKD, including the need for regulation and monitoring of drug manufacturing, the importance of real-world data, and strategies to improve CKD management. The article addresses the cost and availability of medication for individuals with kidney disease, highlighting the paradoxical situation in high-income countries and the catastrophic health expenditure in low- and middle-income countries. It calls for pharmaceutical companies to ensure diverse participation in research studies and fair pricing of effective drugs. The article also emphasizes the need to focus on children with kidney diseases and suggests strategies to improve kidney disease care, including the use of polypills and digital technologies. It concludes with a call to action to address barriers and disparities in access to diagnosis and treatment and to ensure equitable kidney care worldwide. [Extracted from the article]

Published
2024
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21. Dapagliflozin and new-onset type 2 diabetes in patients with chronic kidney disease or heart failure: pooled analysis of the DAPA-CKD and DAPA-HF trials

Author

Rossing, Peter, Inzucchi, Silvio E, Vart, Priya, Jongs, Niels, Docherty, Kieran F, Jhund, Pardeep S, Køber, Lars, Kosiborod, Mikhail N, Martinez, Felipe A, Ponikowski, Piotr, Sabatine, Marc S, Solomon, Scott D, DeMets, David L, Bengtsson, Olof, Lindberg, Magnus, Langkilde, Anna Maria, Sjöstrand, Mikaela, Stefansson, Bergur V, Karlsson, Cecilia, Chertow, Glenn M, Hou, Fan Fan, Correa-Rotter, Ricardo, Toto, Robert D, Wheeler, David C, McMurray, John J V, and Heerspink, Hiddo J L

Published
2022
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22. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function

Author

Heerspink, Hiddo J.L., Wheeler, David C., Chertow, Glenn, Correa-Rotter, Ricardo, Greene, Tom, Hou, Fan Fan, McMurray, John, Rossing, Peter, Toto, Robert, Stefansson, Bergur, Langkilde, Anna Maria, Maffei, L.E., Raffaele, P., Solis, S.E., Arias, C.A., Aizenberg, D., Luquez, C., Zaidman, C., Cluigt, N., Mayer, M., Alvarisqueta, A., Wassermann, A., Maldonado, R., Bittar, J., Maurich, M., Gaite, L.E., Garcia, N., Sivak, L., Ramallo, P.O., Santos, J.C., Garcia Duran, R., Oddino, J.A., Maranon, A., Maia, L.N., Avila, D.D., Barros, E.J.G., Vidotti, M.H., Panarotto, D., Noronha, I.D.L., Turatti, L.A.A., Deboni, L., Canziani, M.E., Riella, M.C., Bacci, M.R., Paschoalin, R.P., Franco, R.J., Goldani, J.C., St-Amour, E., Steele, A.W., Goldenberg, R., Pandeya, S., Bajaj, H., Cherney, D., Kaiser, S.M., Conway, J.R., Chow, S.S., Bailey, G., Lafrance, J., Winterstein, J., Cournoyer, S., Gaudet, D., Madore, F., Houlden, R.L., Dowell, A., Langlois, M., Muirhead, N., Khandwala, H., Levin, A., Hou, F., Xue, Y., Zuo, L., Hao, C., Ni, Z., Xing, C., Chen, N., Dong, Y., Zhou, R., Xiao, X., Zou, Y., Wang, C., Liu, B., Chen, Q., Lin, M., Luo, Q., Zhang, D., Wang, J., Chen, M., Wang, X., Zhong, A., Dong, J., Zhu, C., Yan, T., Luo, P., Ren, Y., Pai, P., Li, D., Zhang, R., Zhang, J., Xu, M., Zhuang, Y., Kong, Y., Yao, X., Peng, X., Persson, F.I., Hansen, T.K., Borg, R., Pedersen Bjergaard, U., Hansen, D., Hornum, M., Haller, H., Klausmann, G., Tschope, D., Kruger, T., Gross, P., Hugo, C., Obermuller, N., Rose, L., Mertens, P., Zeller-Stefan, H., Fritsche, A., Renders, L., Muller, J., Budde, K., Schroppel, B., Wittmann, I., Voros, P., Dudas, M., Tabak, G.A., Kirschner, R., Letoha, A., Balku, I., Hermanyi, Z., Zakar, G., Mezei, I., Nagy, G.G., Lippai, J., Nemeth, A., Khullar, D., Gowdaiah, P.K., Fernando Mervin, E., Rao, V.A., Dewan, D., Goplani, K., Maddi, V.S.K., Vyawahare, M.S., Pulichikkat, R.K., Pandey, R., Sonkar, S.K., Gupta, V.K., Agarwal, S., Asirvatham, A.J., Ignatius, A., Chaubey, S., Melemadathil, S., Alva, H., Kadam, Y., Shimizu, H., Sueyoshi, A., Takeoka, H., Abe, Y., Imai, T., Onishi, Y., Fujita, Y., Tokita, Y., Oura, M., Makita, Y., Idogaki, A., Koyama, R., Kikuchi, H., Kashihara, N., Hayashi, T., Ando, Y., Tanaka, T., Shimizu, M., Hidaka, S., Gohda, T., Tamura, K., Abe, M., Kamijo, Y., Imasawa, T., Takahashi, Y., Nakayama, M., Tomita, M., Hirano, F., Fukushima, Y., Kiyosue, A., Kurioka, S., Imai, E., Kitagawa, K., Waki, M., Wada, J., Uehara, K., Iwatani, H., Ota, K., Shibazaki, S., Katayama, K., Narita, I., Iinuma, M., Matsueda, S., Sasaki, S., Yokochi, A., Tsukamoto, T., Yoshimura, T., Kang, S., Lee, S., Lim, C.S., Chin, H., Joo, K.W., Han, S.Y., Chang, T.I., Park, S., Park, H., Park, C.W., Han, B.G., Cha, D.R., Yoon, S.A., Kim, W., Kim, S.W., Ryu, D., Correa Rotter, R., Irizar Santana, S.S., Hernandez Llamas, G., Valdez Ortiz, R., Secchi Nicolas, N.C., Gonzalez Galvez, G., Lazcano Soto, J.R., Bochicchio Riccardelli, T., Bayram Llamas, E.A., Ramos Ibarra, D.R., Melo, M.G.S., Gonzalez Gonzalez, J.G., Sanchez Mijangos, J.H., Madero Robalo, M., Garcia Castillo, A., Manrique, H.A., Farfan, J.C., Vargas, R., Valdivia, A., Dextre, A., Escudero, E., Calderon Ticona, J.R., Gonzales, L., Villena, J., Leon, L., Molina, G., Saavedra, A., Garrido, E., Arbanil, H., Vargas Marquez, S., Rodriguez, J., Isidto, R., Villaflor, A.J., Gumba, M.A., Tirador, L., Comia, R.S., Sy, R.A., Guanzon, M.L.V.V., Aquitania, G., De Asis, N.C., Silva, A.A., Romero, C.M., Lim, M.E., Danguilan, R.A., Nowicki, M., Rudzki, H., Landa, K., Kucharczyk-Bauman, I., Gogola-Migdal, B., Golski, M., Olech-Cudzik, A., Stompor, T., Szczepanik, T., Miklaszewicz, B., Sciborski, R., Kuzniewski, M., Ciechanowski, K., Wronska, D., Klatko, W., Mazur, S., Popenda, G., Myslicki, M., Bolieva, L.Z., Berns, S., Galyavich, A., Abissova, T., Karpova, I., Platonov, D., Koziolova, N., Kvitkova, L., Nilk, R., Medina, T., Rebrov, A., Rossovskaya, M., Sinitsina, I., Vishneva, E., Zagidullin, N., Novikova, T., Krasnopeeva, N., Magnitskaya, O., Antropenko, N., Batiushin, M., Escudero Quesada, V., Barrios Barrea, C., Espinel Garauz, E., Cruzado Garrit, J.M., Morales Portillo, C., Gorriz Teruel, J.L., Cigarran Guldris, S., Praga Terente, M., Robles Perez-Monteoliva, N.R., Tinahones Madueno, F.J., Soto Gonzalez, A., Diaz Rodriguez, C., Furuland, H., Saeed, A., Dreja, K., Spaak, J., Bruchfeld, A., Kolesnyk, M., Levchenko, O., Pyvovarova, N., Stus, V., Doretskyy, V., Korobova, N., Horoshko, O., Katerenchuk, I., Mostovoy, Y.M., Orynchak, M., Legun, O., Dudar, I., Bilchenko, O., Andreychyn, S., Levchenko, A., Zub, L., Tereshchenko, N., Topchii, I., Ostapenko, T., Bezuglova, S., Kopytsya, M., Turenko, O., Mark, P., Barratt, J., Bhandari, S., Fraser, D., Kalra, P., Kon, S.P., Mccafferty, K., Mikhail, A., Alvarado, O.P., Anderson, R., Andrawis, N.S., Arif, A., Benjamin, S.A., Bueso, G., Busch, R.S., Carr, K.W., Crawford, P., Daboul, N., De La Calle, G.M., Delgado, B., Earl, J., El-Shahawy, M.A., Graf, R.J., Greenwood, G., Guevara, A., Wendland, E.M., Mayfield, R.K., Montero, M., Morin, D.J., Narayan, P., Numrungroad, V., Reddy, A.C., Reddy, R., Samson, M.B., Trejo, R., Butcher, M.B., Wise, J.K., Zemel, L.R., Raikhel, M., Weinstein, D., Hernandez, P., Wynne, A., Khan, B.V., Sterba, G.A., Jamal, A., Ross, D., Rovner, S.F., Tan, A., Ovalle, F., Patel, R.J., Talano, J., Patel, D.R., Burgner, A., Aslam, N., Elliott, M., Goral, S., Jovanovich, A., Manley, J.A., Umanath, K., Waguespack, D., Weiner, D., Yu, M., Schneider, L., Jalal, D., Le, T., Nguyen, N., Nguyen, H., Nguyen, D., Nguyen, V., Do, T., Chu, P., Ta, D., Tran, N., Pham, B., Pfeffer, Marc A., Pocock, Stuart, Swedberg, Karl, Rouleau, Jean L., Chaturvedi, Nishi, Ivanovich, Peter, Levey, Andrew S., Christ-Schmidt, Heidi, Held, Claes, Christersson, Christina, Mann, Johannes, Varenhorst, Christoph, Cherney, David, Postmus, Douwe, Stefánsson, Bergur V., Chertow, Glenn M., Dwyer, Jamie P., Kosiborod, Mikhail, McMurray, John J.V., Sjöström, C. David, and Toto, Robert D.

Published
2022
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27. A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy

Author

Wheeler, David C., Toto, Robert D., Stefánsson, Bergur V., Jongs, Niels, Chertow, Glenn M., Greene, Tom, Hou, Fan Fan, McMurray, John J.V., Pecoits-Filho, Roberto, Correa-Rotter, Ricardo, Rossing, Peter, Sjöström, C. David, Umanath, Kausik, Langkilde, Anna Maria, and Heerspink, Hiddo J.L.

Published
2021
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29. 423.9: The First 52 Global Kidney Exchange Transplants: Overcoming Multiple Barriers to Transplantation

Author

Rees, Michael, Roth, Alvin E., Marino, Ignazio, Krawiak, Kimberly, Rees, Susan, Sweeeney, Krista, Dunn, Ty, Punch, Jeff, Zimmerman, Michael, Aziz, Feroz, Al Obaidli, Ali Abdul Kareem, Ashlagi, Itai, Whittaker, Vaughn, Rege, Aparna, Forbes, Rachel, Kuhr, Christian, Correa-Rotter, Ricardo, Franco, Citterio, Okwenna, Obi, Paloyo, Siegfredo, Sung, Randall, Leventhall, Joseph, Mor, Eytan, Rogers, Jeffery, Tan, Miguel, Basagoitia, Laura, Ellis, Matthew, Anwar, Siddiq, and Romagnoli, Jacopo

Published
2022
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33. Dapagliflozin in chronic kidney disease: cost-effectiveness beyond the DAPA-CKD trial.

Author

McEwan, Phil, Davis, Jason A, Gabb, Peter D, Wheeler, David C, Rossing, Peter, Chertow, Glenn M, Correa-Rotter, Ricardo, Tamura, Kouichi, Barone, Salvatore, and Sanchez, Juan Jose Garcia

Subjects
CHRONIC kidney failure, DAPAGLIFLOZIN, QUALITY-adjusted life years, TYPE 2 diabetes, COST effectiveness
Abstract

Background The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial enrolled patients with estimated glomerular filtration rate 25–75 mL/min/1.73 m2 and urine albumin-to-creatinine ratio >200 mg/g. The Dapagliflozin Effect on CardiovascuLAR Events-Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) trial enrolled patients with type 2 diabetes, a higher range of kidney function and no albuminuria criterion. The study objective was to estimate the cost-effectiveness of dapagliflozin in a broad chronic kidney disease population based on these two trials in the UK, Spain, Italy and Japan. Methods We adapted a published Markov model based on the DAPA-CKD trial but to a broader population, irrespective of urine albumin-to-creatinine ratio, using patient-level data from the DAPA-CKD and DECLARE-TIMI 58 trials. We sourced cost and utility inputs from literature and the DAPA-CKD trial. The analysis considered healthcare system perspectives over a lifetime horizon. Results Treatment with dapagliflozin was predicted to attenuate disease progression and extend projected life expectancy by 0.64 years (12.5 versus 11.9 years, undiscounted) in the UK, with similar estimates in other settings. Clinical benefits translated to mean quality-adjusted life year (QALY; discounted) gains between 0.45 and 0.68 years across countries. Incremental cost-effectiveness ratios in the UK, Spain, Italy and Japan ($10 676/QALY, $14 479/QALY, $7771/QALY and $13 723/QALY, respectively) were cost-effective at country-specific willingness-to-pay thresholds. Subgroup analyses suggest dapagliflozin is cost-effective irrespective of urinary albumin-to-creatine ratio and type 2 diabetes status. Conclusion Treatment with dapagliflozin may be cost-effective for patients across a wider spectrum of estimated glomerular filtration rates and albuminuria than previously demonstrated, with or without type 2 diabetes, in the UK, Spanish, Italian and Japanese healthcare systems. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Efficacy and Safety of Dapagliflozin in Patients With Chronic Kidney Disease Across the Spectrum of Frailty.

Author

Vart, Priya, Butt, Jawad H, Jongs, Niels, Schechter, Meir, Chertow, Glenn M, Wheeler, David C, Pecoits-Filho, Roberto, Langkilde, Anna Maria, Correa-Rotter, Ricardo, Rossing, Peter, McMurray, John J V, and Heerspink, Hiddo J L

Subjects
CHRONIC kidney failure, CHRONICALLY ill, PATIENT safety, FRAILTY, TYPE 2 diabetes
Abstract

Background A sizeable proportion of patients with chronic kidney disease (CKD) are reported to be frail. Here we examined the safety and efficacy of dapagliflozin in patients with CKD by frailty level. Methods Adults with CKD, with/without type 2 diabetes, with an estimated glomerular filtration rate (eGFR) of 25–75 mL/min/1.73 m2, and urinary albumin-to-creatinine ratio 200–5 000 mg/g were randomized to dapagliflozin (10 mg/day) or placebo. The primary endpoint was a composite of sustained ≥50% eGFR decline, end-stage kidney disease (ESKD), or death from kidney or cardiovascular (CV) causes. Results Frailty index (FI), assessed by Rockwood cumulative deficit approach, was calculable in 4 303/4 304 (99.9%) patients: 1 162 (27.0%) in not-to-mildly frail (FI ≤0.210), 1 642 (38.2%) in moderately frail (FI 0.211–0.310), and 1 499 (34.8%) in severely frail categories (FI >0.311). Dapagliflozin reduced the risk of the primary composite endpoint across all FI categories (hazard ratios [95% confidence interval {CI}]: 0.50 [0.33–0.76], 0.62 [0.45–0.85], and 0.64 [0.49–-0.83], respectively; p -interaction = 0.67). Results were similar for secondary outcomes including kidney composite outcome (sustained ≥50% eGFR decline, ESKD or death from kidney cause; p -interaction = 0.44), CV endpoint (heart failure hospitalization or CV death; p -interaction = 0.63), and all-cause mortality (p -interaction p  = .42). Results were consistent when using FI as a continuous variable. Occurrence of serious adverse events was numerically lower in patients receiving dapagliflozin versus placebo in all FI categories (16.9% vs 20.1%, 26.3% vs 30.7%, and 42.9% vs 47.8%, in not-to-mildly, moderately, and severely frail categories, respectively). Conclusions The relative benefit of dapagliflozin for all outcomes was consistent across all frailty categories, with no difference in associated safety. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Mind the gap in kidney care: translating what we know into what we do

Author

Balducci, Alessandro, Liakopoulos, Vassilios, Hsiao, Li-Li, Correa-Rotter, Ricardo, Ulasi, Ifeoma, Kumaraswami, Latha, Lui, Siu Fai, Abdellatif, Dina, Haris, Ágnes, Luyckx, Valerie A., Tuttle, Katherine R., Fung, Winston W.S., Haris, Agnès, Khalife, Makram, Kumaraswami, Latha A., Loud, Fiona, Raghavan, Vasundhara, Roumeliotis, Stefanos, Sierra, Marianella, Wang, Bill, and Lui, Siu-Fai

Published
2024
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42. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

Author

Adu, Dwomoa, Agarwal, Sanjay Kumar, Alrukhaimi, Mona, Anders, Hans-Joachim, Ashuntantang, Gloria, Basnet, Shakti, Bello, Aminu K., Chailimpamontree, Worawon, Correa-Rotter, Ricardo, Craig, Jonathan, Douthat, Walter G., Feldman, Harold I., Ganji, Mohammad Reza, Garcia-Garcia, Guillermo, Gharbi, Mohammed Benghanem, Harris, David C., Jha, Vivekanand, Johnson, David W., Kazancioglu, Rumeyza, Langham, Robyn, Liu, Zhi-Hong, Massy, Ziad A., Nangaku, Masaomi, Nelson, Robert G., O'Donoghue, Donal, Okpechi, Ikechi, Pecoits-Filho, Roberto, Powe, Neil R., Remuzzi, Giuseppe, Roberts, Charlotte, Rossert, Jerome, Sola, Laura, Stengel, Benedicte, M, Ernest K. Sumaili, Suzuki, Yusuke, Tanaka, Tetsuhiro, Tatiyanupanwong, Sajja, Thomas, Bernadette, Uhlig, Katrin, Walker, Robert, White, Sarah L., Wiecek, Andrzej, Yang, Chih-Wei, Levin, Adeera, Tonelli, Marcello, Bonventre, Joseph, Coresh, Josef, Donner, Jo-Ann, Fogo, Agnes B, Fox, Caroline S, Gansevoort, Ron T, Heerspink, Hiddo J L, Jardine, Meg, Kasiske, Bertram, Köttgen, Anna, Kretzler, Matthias, Levey, Andrew S, Luyckx, Valerie A, Mehta, Ravindra, Moe, Orson, Obrador, Gregorio, Pannu, Neesh, Parikh, Chirag R, Perkovic, Vlado, Pollock, Carol, Stenvinkel, Peter, Tuttle, Katherine R, Wheeler, David C, and Eckardt, Kai-Uwe

Published
2017
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45. Dissonant health transition in the states of Mexico, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Author

Gómez-Dantés, Héctor, Fullman, Nancy, Lamadrid-Figueroa, Héctor, Cahuana-Hurtado, Lucero, Darney, Blair, Avila-Burgos, Leticia, Correa-Rotter, Ricardo, Rivera, Juan A, Barquera, Simon, González-Pier, Eduardo, Aburto-Soto, Tania, de Castro, Elga Filipa Amorin, Barrientos-Gutiérrez, Tonatiuh, Basto-Abreu, Ana C, Batis, Carolina, Borges, Guilherme, Campos-Nonato, Ismael, Campuzano-Rincón, Julio C, de Jesús Cantoral-Preciado, Alejandra, Contreras-Manzano, Alejandra G, Cuevas-Nasu, Lucia, de la Cruz-Gongora, Vanessa V, Diaz-Ortega, Jose L, de Lourdes García-García, María, Garcia-Guerra, Armando, de Cossío, Teresita González, González-Castell, Luz D, Heredia-Pi, Ileana, Hijar-Medina, Marta C, Jauregui, Alejandra, Jimenez-Corona, Aida, Lopez-Olmedo, Nancy, Magis-Rodríguez, Carlos, Medina-Garcia, Catalina, Medina-Mora, Maria E, Mejia-Rodriguez, Fabiola, Montañez, Julio C, Montero, Pablo, Montoya, Alejandra, Moreno-Banda, Grea L, Pedroza-Tobías, Andrea, Pérez-Padilla, Rogelio, Quezada, Amado D, Richardson-López-Collada, Vesta L, Riojas-Rodríguez, Horacio, Ríos Blancas, Maria J, Razo-Garcia, Christian, Mendoza, Martha P Romero, Sánchez-Pimienta, Tania G, Sánchez-Romero, Luz M, Schilmann, Astrid, Servan-Mori, Edson, Shamah-Levy, Teresa, Téllez-Rojo, Martha M, Texcalac-Sangrador, José L, Wang, Haidong, Vos, Theo, Forouzanfar, Mohammad H, Naghavi, Mohsen, Lopez, Alan D, Murray, Christopher J L, and Lozano, Rafael

Published
2016
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48. Optimizing peritoneal dialysis initiation: A comparative cohort study of catheter placement methods for shortening break‐in periods.

Author

Chávez‐Chávez, Hugo E., Hernández‐Paredes, Elisa Naomi, Cojuc‐Konigsberg, Gabriel, Vargas‐Rodríguez, Cecilia, Díaz‐Canchola, Laura Margarita, Vergara‐Zavala, Octavio, Fernández‐Venegas, Alonso, Acevedo‐Juárez, Nadia Stephani, Correa‐Rotter, Ricardo, and Ramirez‐Sandoval, Juan C.

Subjects
CATHETERIZATION, PERITONEAL dialysis, DIALYSIS catheters, COHORT analysis, COMPARATIVE studies, CHRONIC kidney failure
Abstract

Introduction: Peritoneal dialysis (PD) guidelines recommend a 14‐day break‐in period after catheter placement, yet this period could be shortened with new insertion techniques. Methods: We conducted a prospective cohort study to compare percutaneous vs. surgical catheter insertion in a newly established PD program. The break‐in period was intentionally shortened to <24 h to start PD almost immediately. Results: We included 223 subjects who underwent percutaneous (34%) or surgical (66%) catheter placement. Compared to the surgical group, the percutaneous group had a higher proportion of early dialysis initiation within 24 h (97% vs. 8%, p < 0.001), similar successful initiation rates (87% vs. 92%, p = 0.34), and shorter lengths of stay (12 [9–18] vs. 18 [14–22] days, p < 0.001). Percutaneous insertion increased the likelihood of successful PD initiation within 24 h (OR 74, 95% CI 31–182), without increasing major complications. Conclusion: Percutaneous placement could represent a cost‐effective and efficient technique to shorten break‐in periods. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Improved β2-Microglobulin and Phosphorous Removal with Expanded Hemodialysis and Online Hemodiafiltration versus High-Flux Hemodialysis: A Cross-Over Randomized Clinical Trial.

Author

Vega-Vega, Olynka, Caballero-Islas, Adrián E., Del Toro-Cisneros, Noemí, Hernandez-Ordoñez, Sergio Óscar, Arvizu-Hernández, Mauricio, Martínez-Rueda, Armando, Camacho-Colin, Diana, Gómez-Correa, Leidi Laura, and Correa-Rotter, Ricardo

Subjects
HEMODIAFILTRATION, CLINICAL trials, SERUM albumin, ALBUMINS, INTERLEUKIN-6, INTERLEUKIN-10
Abstract

Introduction: Expanded hemodialysis (HDx) is expected to provide enhanced permeability of medium-sized molecules, selective solute retention, and better internal retrofiltration. The primary objective of this study was to compare the efficiency for removal of β2-microglobulin with 3 different extracorporeal therapies (ETs): high-flux hemodialysis (HF), online hemodiafiltration (OL-HDF), and HDx. The secondary objective was to evaluate the efficiency of removal of other uremic toxins, including urea, phosphate, CRP, IL-6, IL-10, TNF-⍺, indoxyl sulfate, and p-cresol. Methods: This single-center, randomized, and cross-over study was performed. Patients were randomized to determine the initial modality of treatment, each period lasted 4 weeks and between one modality and another, there was a washout period of 1 week. Reduction ratios (RRs) of different-size molecules and albumin were calculated for the different ET. Results: Twenty-two patients were included, β2-microglobulin RR was greater during both OL-HDF and HDx as compared to HF (RR 62% vs. 73% vs. 27%, respectively, p = <0.0001), and there was no significant difference between HDx and OL-HDF (p = 0.09). A decrease in serum phosphate levels was observed in the HDx and OL-HDF periods, contrary to an increase in HF (−0.79 mg/dL vs. −1.02 mg/dL vs. + 0.11 mg/dL, respectively, p = <0.0001). There was no difference in RRs of other molecules (BUN, CRP, IL-6, IL-10, TNF-⍺, indoxyl sulfate, and p-Cresol). There was no decrease in serum albumin in any ET. Conclusion: HDx provides enhanced removal of β2-microglobulin and phosphate as compared to HF, and similar efficacy as with OL-HDF. HDx should be considered an alternative to chronic convective therapies. [ABSTRACT FROM AUTHOR]

Published
2023
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