681 results on '"Corbett, Elizabeth L."'
Search Results
2. Community-based active-case finding for tuberculosis: navigating a complex minefield
- Author
-
MacPherson, Peter, Shanaube, Kwame, Phiri, Mphatso D., Rickman, Hannah M., Horton, Katherine C., Feasey, Helena R. A., Corbett, Elizabeth L., Burke, Rachael M., and Rangaka, Molebogeng X.
- Published
- 2024
- Full Text
- View/download PDF
3. Cost-effectiveness of COVID rapid diagnostic tests for patients with severe/critical illness in low- and middle-income countries: A modeling study
- Author
-
Bonnet, Gabrielle, Bimba, John, Chavula, Chancy, Chifamba, Harunavamwe N., Divala, Titus H., Lescano, Andres G., Majam, Mohammed, Mbo, Danjuma, Suwantika, Auliya A., Tovar, Marco A., Yadav, Pragya, Ekwunife, Obinna, Mangenah, Collin, Ngwira, Lucky G., Corbett, Elizabeth L., Jit, Mark, and Vassall, Anna
- Subjects
Medical economics -- Health aspects ,Diseases -- Diagnosis ,Decision-making -- Health aspects ,Health care industry -- Health aspects ,Influenza -- Diagnosis ,Interleukins -- Health aspects ,Severe acute respiratory syndrome -- Diagnosis ,Coronaviruses -- Health aspects ,Health care industry ,Biological sciences ,World Health Organization - Abstract
Background Rapid diagnostic tests (RDTs) for coronavirus disease (COVID) are used in low- and middle-income countries (LMICs) to inform treatment decisions. However, to date, it is unclear when this use is cost-effective. Existing analyses are limited to a narrow set of countries and uses. The aim of this study is to assess the cost-effectiveness of COVID RDTs to inform the treatment of patients with severe illness in LMICs, considering real world practice. Methods and findings We assessed the cost-effectiveness of COVID testing across LMICs using a decision tree model, differentiating results by country income level, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) prevalence, and testing scenario (none, RDTs, polymerase chain reaction tests-PCRs and combinations). LMIC experts defined realistic care pathways and treatment options. Using a healthcare provider perspective and net monetary benefit approach, we assessed both intended (COVID symptom alleviation) and unintended (treatment side effects) health and economic impacts for each testing scenario. We included the side effects of corticosteroids, which are often the only available treatment for COVID. Because side effects depend both on the treatment and the patient's underlying illness (COVID or COVID-like illnesses, such as influenza), we considered the prevalence of COVID-like illnesses in our analyses. We found that SARS-CoV-2 testing of patients with severe COVID-like illness can be cost-effective in all LMICs, though only in some circumstances. High influenza prevalence among suspected COVID cases improves cost-effectiveness, since incorrectly provided corticosteroids may worsen influenza outcomes. In low- and some lower-middle-income countries, only patients with a high index of suspicion for COVID should be tested with RDTs, while other patients should be presumed to not have COVID. In some lower-middle-income and upper-middle-income countries, suspected severe COVID cases should almost always be tested. Further, in these settings, negative test results in patients with a high initial index of suspicion should be confirmed through PCR and, during influenza outbreaks, positive results in patients with a low initial index of suspicion should also be confirmed with a PCR. The use of interleukin-6 receptor blockers, when supported by testing, may also be cost-effective in higher-income LMICs. The cost at which they would be cost-effective in low-income countries ($162 to $406 per treatment course) is below current prices. The primary limitation of our analysis is substantial uncertainty around some of the parameters in our model due to limited data, most notably on current COVID mortality with standard of care, and insufficient evidence on the impact of corticosteroids on patients with severe influenza. Conclusions COVID testing can be cost-effective to inform treatment of LMIC patients with severe COVID-like disease. The optimal algorithm is driven by country income level and health budgets, the level of suspicion that the patient may have COVID, and influenza prevalence. Further research to better characterize the unintended effects of corticosteroids, particularly on influenza cases, could improve decision making around the treatment of those with COVID-like symptoms in LMICs., Author(s): Gabrielle Bonnet 1,*, John Bimba 2,3, Chancy Chavula 4, Harunavamwe N. Chifamba 5, Titus H. Divala 6, Andres G. Lescano 7, Mohammed Majam 8, Danjuma Mbo 9, Auliya A. [...]
- Published
- 2024
- Full Text
- View/download PDF
4. Diagnostic accuracy of a three-gene Mycobacterium tuberculosis host response cartridge using fingerstick blood for childhood tuberculosis: a multicentre prospective study in low-income and middle-income countries
- Author
-
Baard, Cynthia Biddle, Munro, Jacinta Diane, Prins, Margaretha, Benzi, Nolufefe, Bateman, Linda Claire, Ryan, Ashleigh, Booi, Kutala, Paulo, Nezisa, Heydenrych, Anthenette, Petersen, Wonita, Brookes, Raquel, Mento, Michele, Centner, Chad, Dalgarno, Craig, Rieß, Friedrich, Mutuku, Sarah, Saathoff, Elmar, Held, Kathrin, Ninan, Marilyn Mary, Chacko, Anila, Kumari, Ramya, Dhanabhagyam, R, Muniswamy, Nithya, Nicol, Marc P, Mtafya, Bariki, Mwambola, Harieth, Manyama, Christina, Mahiga, Hellen, Sichone, Emanuel, Sudi, Lwitiho, Maueia, Cremildo, Madeira, Carla, Cambuie, Justina, Ribeiro, Jorge, Chiume, Lingstone, Mnyanga, Alice, Sikwese, Tionge, Masakasa, Happy, Kachere, Diana, Kosaka, Masheck, Niemann, Stefan, Chegou, Novel, Horn, Lyn, Olbrich, Laura, Verghese, Valsan P, Franckling-Smith, Zoe, Sabi, Issa, Ntinginya, Nyanda E, Mfinanga, Alfred, Banze, Denise, Viegas, Sofia, Khosa, Celso, Semphere, Robina, Nliwasa, Marriott, McHugh, Timothy D, Larsson, Leyla, Razid, Alia, Song, Rinn, Corbett, Elizabeth L, Nabeta, Pamela, Trollip, Andre, Graham, Stephen M, Hoelscher, Michael, Geldmacher, Christof, Zar, Heather J, Michael, Joy Sarojini, and Heinrich, Norbert
- Published
- 2024
- Full Text
- View/download PDF
5. Trial-of-antibiotics to assist tuberculosis diagnosis in symptomatic adults in Malawi (ACT-TB study): a randomised controlled trial
- Author
-
Divala, Titus H, Corbett, Elizabeth L, Kandulu, Chikondi, Moyo, Brewster, MacPherson, Peter, Nliwasa, Marriott, French, Neil, Sloan, Derek J, Chiume, Lingstone, Ndaferankhande, Masiye John, Chilanga, Sanderson, Majiga, Sabina Tazirwa, Odland, Jon Øyvind, and Fielding, Katherine L
- Published
- 2023
- Full Text
- View/download PDF
6. Social mixing patterns relevant to infectious diseases spread by close contact in urban Blantyre, Malawi
- Author
-
Thindwa, Deus, Jambo, Kondwani C., Ojal, John, MacPherson, Peter, Dennis Phiri, Mphatso, Pinsent, Amy, Khundi, McEwen, Chiume, Lingstone, Gallagher, Katherine E., Heyderman, Robert S., Corbett, Elizabeth L., French, Neil, and Flasche, Stefan
- Published
- 2022
- Full Text
- View/download PDF
7. Risk factors for sustained virological non-suppression among children and adolescents living with HIV in Zimbabwe and Malawi: a secondary data analysis
- Author
-
Jackson, Christi, Rehman, Andrea M., McHugh, Grace, Gonzalez-Martinez, Carmen, Ngwira, Lucky G., Bandason, Tsitsi, Mujuru, Hilda, Odland, Jon O., Corbett, Elizabeth L., Ferrand, Rashida A., and Simms, Victoria
- Published
- 2022
- Full Text
- View/download PDF
8. Effects of Coronavirus Disease Pandemic on Tuberculosis Notifications, Malawi
- Author
-
Soko, Rebecca Nzawa, Burke, Rachael M., Feasey, Helena R.A., Sibande, Wakumanya, Nliwasa, Marriott, Henrion, Marc Y.R., Khundi, McEwen, Dodd, Peter J., Ku, Chu Chang, Kawalazira, Gift, Choko, Augustine T., Divala, Titus H., Corbett, Elizabeth L., and MacPherson, Peter
- Subjects
Epidemics -- Statistics -- Influence -- Control -- Malawi ,Tuberculosis -- Statistics -- Diagnosis -- Care and treatment ,Health - Abstract
Tuberculosis (TB) is a major killer, causing [approximately equal to] 1,4 million deaths worldwide annually (1), making it second only to coronavirus disease (COVID-19) as the biggest cause of infectious [...]
- Published
- 2021
- Full Text
- View/download PDF
9. Partner-delivered HIV self-test kits with and without financial incentives in antenatal care and index patients with HIV in Malawi: a three-arm, cluster-randomised controlled trial
- Author
-
Choko, Augustine T, Fielding, Katherine, Johnson, Cheryl C, Kumwenda, Moses K, Chilongosi, Richard, Baggaley, Rachel C, Nyirenda, Rose, Sande, Linda A, Desmond, Nicola, Hatzold, Karin, Neuman, Melissa, and Corbett, Elizabeth L
- Published
- 2021
- Full Text
- View/download PDF
10. Community-based active case-finding interventions for tuberculosis: a systematic review
- Author
-
Burke, Rachael M, Nliwasa, Marriott, Feasey, Helena R A, Chaisson, Lelia H, Golub, Jonathan E, Naufal, Fahd, Shapiro, Adrienne E, Ruperez, Maria, Telisinghe, Lily, Ayles, Helen, Corbett, Elizabeth L, and MacPherson, Peter
- Published
- 2021
- Full Text
- View/download PDF
11. Characterization of bacterial and viral pathogens in the respiratory tract of children with HIV-associated chronic lung disease: a case–control study.
- Author
-
Mushunje, Prince K., Dube, Felix S., Olwagen, Courtney, Madhi, Shabir, Odland, Jon Ø, Ferrand, Rashida A., Nicol, Mark P., Abotsi, Regina E., Bandason, Tsitsi, Dauya, Ethel, Madanhire, Tafadzwa, Corbett, Elizabeth L., Kranzer, Katharina, Majonga, Edith D., Simms, Victoria, Rehman, Andrea M., A.Weiss, Helen, Mujuru, Hilda, Bowen, Dan, and Yindom, Louis-Marie
- Subjects
HUMAN metapneumovirus infection ,LUNG diseases ,CHRONIC diseases ,HIV-positive children ,CASE-control method ,LOGISTIC regression analysis - Abstract
Introduction: Chronic lung disease is a major cause of morbidity in African children with HIV infection; however, the microbial determinants of HIV-associated chronic lung disease (HCLD) remain poorly understood. We conducted a case–control study to investigate the prevalence and densities of respiratory microbes among pneumococcal conjugate vaccine (PCV)-naive children with (HCLD +) and without HCLD (HCLD-) established on antiretroviral treatment (ART). Methods: Nasopharyngeal swabs collected from HCLD + (defined as forced-expiratory-volume/second < -1.0 without reversibility postbronchodilation) and age-, site-, and duration-of-ART-matched HCLD- participants aged between 6–19 years enrolled in Zimbabwe and Malawi (BREATHE trial-NCT02426112) were tested for 94 pneumococcal serotypes together with twelve bacteria, including Streptococcus pneumoniae (SP), Staphylococcus aureus (SA), Haemophilus influenzae (HI), Moraxella catarrhalis (MC), and eight viruses, including human rhinovirus (HRV), respiratory syncytial virus A or B, and human metapneumovirus, using nanofluidic qPCR (Standard BioTools formerly known as Fluidigm). Fisher's exact test and logistic regression analysis were used for between-group comparisons and risk factors associated with common respiratory microbes, respectively. Results: A total of 345 participants (287 HCLD + , 58 HCLD-; median age, 15.5 years [IQR = 12.8–18], females, 52%) were included in the final analysis. The prevalence of SP (40%[116/287] vs. 21%[12/58], p = 0.005) and HRV (7%[21/287] vs. 0%[0/58], p = 0.032) were higher in HCLD + participants compared to HCLD- participants. Of the participants positive for SP (116 HCLD + & 12 HCLD-), 66% [85/128] had non-PCV-13 serotypes detected. Overall, PCV-13 serotypes (4, 19A, 19F: 16% [7/43] each) and NVT 13 and 21 (9% [8/85] each) predominated. The densities of HI (2 × 10
4 genomic equivalents [GE/ml] vs. 3 × 102 GE/ml, p = 0.006) and MC (1 × 104 GE/ml vs. 1 × 103 GE/ml, p = 0.031) were higher in HCLD + compared to HCLD-. Bacterial codetection (≥ any 2 bacteria) was higher in the HCLD + group (36% [114/287] vs. (19% [11/58]), (p = 0.014), with SP and HI codetection (HCLD + : 30% [86/287] vs. HCLD-: 12% [7/58], p = 0.005) predominating. Viruses (predominantly HRV) were detected only in HCLD + participants. Lastly, participants with a history of previous tuberculosis treatment were more likely to carry SP (adjusted odds ratio (aOR): 1.9 [1.1 -3.2], p = 0.021) or HI (aOR: 2.0 [1.2 – 3.3], p = 0.011), while those who used ART for ≥ 2 years were less likely to carry HI (aOR: 0.3 [0.1 – 0.8], p = 0.005) and MC (aOR: 0.4 [0.1 – 0.9], p = 0.039). Conclusion: Children with HCLD + were more likely to be colonized by SP and HRV and had higher HI and MC bacterial loads in their nasopharynx. The role of SP, HI, and HRV in the pathogenesis of CLD, including how they influence the risk of acute exacerbations, should be studied further. Trial registration: The BREATHE trial (ClinicalTrials.gov Identifier: NCT02426112, registered date: 24 April 2015). [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
12. Tuberculosis Immunoreactivity Surveillance in Malawi (Timasamala)—A protocol for a cross-sectional Mycobacterium tuberculosis immunoreactivity survey in Blantyre, Malawi.
- Author
-
Rickman, Hannah M., Phiri, Mphatso D., Feasey, Helena R. A., Mbale, Hannah, Nliwasa, Marriott, Semphere, Robina, Chagaluka, George, Fielding, Katherine, Mwandumba, Henry C., Horton, Katherine C., Nightingale, Emily S., Henrion, Marc Y. R., Mbendera, Kuzani, Mpunga, James A., Corbett, Elizabeth L., and MacPherson, Peter
- Subjects
MYCOBACTERIUM tuberculosis ,ORPHANS ,LATENT infection ,INTERFERON gamma release tests ,CONVENIENCE sampling (Statistics) ,TUBERCULOSIS ,REMOTE-sensing images - Abstract
Tuberculosis (TB) transmission and prevalence are dynamic over time, and heterogeneous within populations. Public health programmes therefore require up-to-date, accurate epidemiological data to appropriately allocate resources, target interventions, and track progress towards End TB goals. Current methods of TB surveillance often rely on case notifications, which are biased by access to healthcare, and TB disease prevalence surveys, which are highly resource-intensive, requiring many tens of thousands of people to be tested to identify high-risk groups or capture trends. Surveys of "latent TB infection", or immunoreactivity to Mycobacterium tuberculosis (Mtb), using tests such as interferon-gamma release assays (IGRAs) could provide a way to identify TB transmission hotspots, supplementing information from disease notifications, and with greater spatial and temporal resolution than is possible to achieve in disease prevalence surveys. This cross-sectional survey will investigate the prevalence of Mtb immunoreactivity amongst young children, adolescents and adults in Blantyre, Malawi, a high HIV-prevalence city in southern Africa. Through this study we will estimate the annual risk of TB infection (ARTI) in Blantyre and explore individual- and area-level risk factors for infection, as well as investigating geospatial heterogeneity of Mtb infection (and its determinants), and comparing these to the distribution of TB disease case-notifications. We will also evaluate novel diagnostics for Mtb infection (QIAreach QFT) and sampling methodologies (convenience sampling in healthcare settings and community sampling based on satellite imagery), which may increase the feasibility of measuring Mtb infection at large scale. The overall aim is to provide high-resolution epidemiological data and provide new insights into methodologies which may be used by TB programmes globally. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. Accuracy of and preferences for blood-based versus oral-fluid-based HIV self-testing in Malawi: a cross-sectional study.
- Author
-
O'Reilly, Ailva, Mavhu, Webster, Neuman, Melissa, Kumwenda, Moses K., Johnson, Cheryl C., Sinjani, George, Indravudh, Pitchaya, Choko, Augustin, Hatzold, Karin, and Corbett, Elizabeth L.
- Subjects
HIV testing kits ,PATIENT self-monitoring ,CROSS-sectional method ,DIAGNOSIS of HIV infections ,BLOOD products ,RURAL health clinics - Abstract
Background: HIV self-testing (HIVST) can use either oral-fluid or blood-based tests. Studies have shown strong preferences for self-testing compared to facility-based services. Despite availability of low-cost blood-based HIVST options, to date, HIVST implementation in sub-Saharan Africa has largely been oral-fluid-based. We investigated whether users preferred blood-based (i.e. using blood sample derived from a finger prick) or oral fluid-based HIVST in rural and urban Malawi. Methods: At clinics providing HIV testing services (n = 2 urban; n = 2 rural), participants completed a semi-structured questionnaire capturing sociodemographic data before choosing to test using oral-fluid-based HVST, blood-based HIVST or provider-delivered testing. They also completed a self-administered questionnaire afterwards, followed by a confirmatory test using the national algorithm then appropriate referral. We used simple and multivariable logistic regression to identify factors associated with preference for oral-fluid or blood-based HIVST. Results: July to October 2018, N = 691 participants enrolled in this study. Given the choice, 98.4% (680/691) selected HIVST over provider-delivered testing. Of 680 opting for HIVST, 416 (61.2%) chose oral-fluid-based HIVST, 264 (38.8%) chose blood-based HIVST and 99.1% (674/680) reported their results appropriately. Self-testers who opted for blood-based HIVST were more likely to be male (50.3% men vs. 29.6% women, p < 0.001), attending an urban facility (43% urban vs. 34.6% rural, p = 0.025) and regular salary-earners (49.5% regular vs. 36.8% non-regular, p = 0.012). After adjustment, only sex was found to be associated with choice of self-test (adjusted OR 0.43 (95%CI: 0.3–0.61); p-value < 0.001). Among 264 reporting blood-based HIVST results, 11 (4.2%) were HIV-positive. Blood-based HIVST had sensitivity of 100% (95% CI: 71.5–100%) and specificity of 99.6% (95% CI: 97.6–100%), with 20 (7.6%) invalid results. Among 416 reporting oral-fluid-based HIVST results 18 (4.3%) were HIV-positive. Oral-fluid-based HIVST had sensitivity of 88.9% (95% CI: 65.3–98.6%) and specificity of 98.7% (95% CI: 97.1–99.6%), with no invalid results. Conclusions: Offering both blood-based and oral-fluid-based HIVST resulted in high uptake when compared directly with provider-delivered testing. Both types of self-testing achieved high accuracy among users provided with a pre-test demonstration beforehand. Policymakers and donors need to adequately plan and budget for the sensitisation and support needed to optimise the introduction of new quality-assured blood-based HIVST products. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Costs of HIV testing services in sub-Saharan Africa: a systematic literature review
- Author
-
Ahmed, Nurilign, Ong, Jason J., McGee, Kathleen, d’Elbée, Marc, Johnson, Cheryl, Cambiano, Valentina, Hatzold, Karin, Corbett, Elizabeth L., Terris-Prestholt, Fern, and Maheswaran, Hendramoorthy
- Published
- 2022
- Full Text
- View/download PDF
15. Accuracy of and preferences for blood-based versus oral-fluid-based HIV self-testing in Malawi: a cross-sectional study
- Author
-
O’Reilly, Ailva, Mavhu, Webster, Neuman, Melissa, Kumwenda, Moses K., Johnson, Cheryl C., Sinjani, George, Indravudh, Pitchaya, Choko, Augustin, Hatzold, Karin, and Corbett, Elizabeth L.
- Published
- 2022
- Full Text
- View/download PDF
16. Experience of social harms among female sex workers following HIV self-test distribution in Malawi: results of a cohort study
- Author
-
Mee, Paul, Neuman, Melissa, Kumwenda, Moses, Lora, Wezzie S., Sikwese, Simon, Sambo, Mwiza, Fielding, Katherine, Indravudh, Pitchaya P., Hatzold, Karin, Johnson, Cheryl, Corbett, Elizabeth. L., and Desmond, Nicola
- Published
- 2022
- Full Text
- View/download PDF
17. Lessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation
- Author
-
Simwinga, Musonda, Gwanu, Lwiindi, Hensen, Bernadette, Sigande, Lucheka, Mainga, Mwami, Phiri, Thokozile, Mwanza, Eliphas, Kabumbu, Mutale, Mulubwa, Chama, Mwenge, Lawrence, Bwalya, Chiti, Kumwenda, Moses, Mubanga, Ellen, Mee, Paul, Johnson, Cheryl C., Corbett, Elizabeth L., Hatzold, Karin, Neuman, Melissa, Ayles, Helen, and Taegtmeyer, Miriam
- Published
- 2022
- Full Text
- View/download PDF
18. Sensitivity and specificity of OraQuick® HIV self-test compared to a 4th generation laboratory reference standard algorithm in urban and rural Zambia
- Author
-
Neuman, Melissa, Mwinga, Alwyn, Kapaku, Kezia, Sigande, Lucheka, Gotsche, Caroline, Taegtmeyer, Miriam, Dacombe, Russell, Maluzi, Kwitaka, Kosloff, Barry, Johnson, Cheryl, Hatzold, Karin, Corbett, Elizabeth L., and Ayles, Helen
- Published
- 2022
- Full Text
- View/download PDF
19. Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study
- Author
-
Gupta-Wright, Ankur, Fielding, Katherine, van Oosterhout, Joep J, Alufandika, Melanie, Grint, Daniel J, Chimbayo, Elizabeth, Heaney, Judith, Byott, Matthew, Nastouli, Eleni, Mwandumba, Henry C, Corbett, Elizabeth L, and Gupta, Ravindra K
- Published
- 2020
- Full Text
- View/download PDF
20. Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults: a systematic review and meta-analysis
- Author
-
Divala, Titus H, Fielding, Katherine L, Kandulu, Chikondi, Nliwasa, Marriott, Sloan, Derek J, Gupta-Wright, Ankur, and Corbett, Elizabeth L
- Published
- 2020
- Full Text
- View/download PDF
21. Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data
- Author
-
Barr, David A, Lewis, Joseph M, Feasey, Nicholas, Schutz, Charlotte, Kerkhoff, Andrew D, Jacob, Shevin T, Andrews, Ben, Kelly, Paul, Lakhi, Shabir, Muchemwa, Levy, Bacha, Helio A, Hadad, David J, Bedell, Richard, van Lettow, Monique, Zachariah, Rony, Crump, John A, Alland, David, Corbett, Elizabeth L, Gopinath, Krishnamoorthy, Singh, Sarman, Griesel, Rulan, Maartens, Gary, Mendelson, Marc, Ward, Amy M, Parry, Christopher M, Talbot, Elizabeth A, Munseri, Patricia, Dorman, Susan E, Martinson, Neil, Shah, Maunank, Cain, Kevin, Heilig, Charles M, Varma, Jay K, von Gottberg, Anne, Sacks, Leonard, Wilson, Douglas, Squire, S Bertel, Lalloo, David G, Davies, Gerry, and Meintjes, Graeme
- Published
- 2020
- Full Text
- View/download PDF
22. Tuberculosis case notifications in Malawi have strong seasonal and weather-related trends
- Author
-
Kirolos, Amir, Thindwa, Deus, Khundi, McEwen, Burke, Rachael M., Henrion, Marc Y. R., Nakamura, Itaru, Divala, Titus H., Nliwasa, Marriott, Corbett, Elizabeth L., and MacPherson, Peter
- Published
- 2021
- Full Text
- View/download PDF
23. ‘Too old to test?’: A life course approach to HIV-related risk and self-testing among midlife-older adults in Malawi
- Author
-
Johnson, Cheryl, Kumwenda, Moses, Meghji, Jamilah, Choko, Augustine T., Phiri, Mackwellings, Hatzold, Karin, Baggaley, Rachel, Taegtmeyer, Miriam, Terris-Prestholt, Fern, Desmond, Nicola, and Corbett, Elizabeth L.
- Published
- 2021
- Full Text
- View/download PDF
24. Tuberculosis diagnosis cascade in Blantyre, Malawi: a prospective cohort study
- Author
-
Feasey, Helena R. A., Corbett, Elizabeth L., Nliwasa, Marriott, Mair, Luke, Divala, Titus H., Kamchedzera, Wala, Khundi, Mc Ewen, Burchett, Helen E. D., Webb, Emily L., Maheswaran, Hendramoorthy, Squire, S. Bertel, and MacPherson, Peter
- Published
- 2021
- Full Text
- View/download PDF
25. Durations of asymptomatic, symptomatic, and care-seeking phases of tuberculosis disease with a Bayesian analysis of prevalence survey and notification data
- Author
-
Ku, Chu-Chang, MacPherson, Peter, Khundi, McEwen, Nzawa Soko, Rebecca H., Feasey, Helena R. A., Nliwasa, Marriott, Horton, Katherine C., Corbett, Elizabeth L., and Dodd, Peter J.
- Published
- 2021
- Full Text
- View/download PDF
26. Systematic Review and Meta-Analysis of Sex Differences in Social Contact Patterns and Implications for Tuberculosis Transmission and Control
- Author
-
Horton, Katherine C., Hoey, Anne L., Beraud, Guillaume, Corbett, Elizabeth L., and White, Richard G.
- Subjects
Tuberculosis -- Distribution -- Methods -- Health aspects ,Sex differences (Biology) -- Health aspects -- Methods ,Contact tracing -- Demographic aspects -- Methods -- Health aspects ,Public health administration -- Methods -- Health aspects ,Company distribution practices ,Health - Abstract
Tuberculosis (TB) is the leading infectious cause of death worldwide; there were an estimated 1.3 million deaths during 2017 (1). Approximately 25% of the world's population is infected with Mycobacterium [...]
- Published
- 2020
- Full Text
- View/download PDF
27. Cost-effectiveness of urine-based tuberculosis screening in hospitalised patients with HIV in Africa: a microsimulation modelling study
- Author
-
Reddy, Krishna P, Gupta-Wright, Ankur, Fielding, Katherine L, Costantini, Sydney, Zheng, Amy, Corbett, Elizabeth L, Yu, Liyang, van Oosterhout, Joep J, Resch, Stephen C, Wilson, Douglas P, Horsburgh, C Robert, Jr, Wood, Robin, Alufandika-Moyo, Melanie, Peters, Jurgens A, Freedberg, Kenneth A, Lawn, Stephen D, and Walensky, Rochelle P
- Published
- 2019
- Full Text
- View/download PDF
28. Incidence of HIV-positive admission and inpatient mortality in Malawi (2012–2019)
- Author
-
Burke, Rachael M., Henrion, Marc Y.R., Mallewa, Jane, Masamba, Leo, Kalua, Thokozani, Khundi, McEwen, Gupta-Wright, Ankur, Rylance, Jamie, Gordon, Stephen B., Masesa, Clemens, Corbett, Elizabeth L., Mwandumba, Henry C., and Macpherson, Peter
- Published
- 2021
- Full Text
- View/download PDF
29. Experience of social harms among female sex workers following HIV self-test distribution in Malawi: results of a cohort study.
- Author
-
Mee, Paul, Neuman, Melissa, Kumwenda, Moses, Lora, Wezzie S., Sikwese, Simon, Sambo, Mwiza, Fielding, Katherine, Indravudh, Pitchaya P., Hatzold, Karin, Johnson, Cheryl, Corbett, Elizabeth. L., and Desmond, Nicola
- Subjects
SEX workers ,HIV testing kits ,PATIENT self-monitoring ,HIV ,SEXUAL intercourse - Abstract
Background: In Malawi, female sex workers (FSW) have high HIV incidence and regular testing is suggested. HIV self-testing (HIVST) is a safe and acceptable alternative to standard testing services. This study assessed; whether social harms were more likely to be reported after HIVST distribution to FSW by peer distributors than after facility-based HIV testing and whether FSW regretted HIVST use or experienced associated relationship problems. Methods: Peer HIVST distributors, who were FSW, were recruited in Blantyre district, Malawi between February and July 2017. Among HIVST recipients a prospective cohort was recruited. Interviews were conducted at baseline and at end-line, 3 months later. Participants completed daily sexual activity diaries. End-line data were analysed using logistic regression to assess whether regret or relationship problems were associated with HIVST use. Sexual activity data were analysed using Generalised Estimating Equations to assess whether HIVST use was temporally associated with an increase in social harms. Results: Of 265 FSW recruited and offered HIVST, 131 completed both interviews. Of these, 31/131(23.7%) reported initial regret after HIVST use, this reduced to 23/131(17.6%) at the 3-month follow-up. Relationship problems were reported by 12/131(9.2%). Regret about HIVST use was less commonly reported in those aged 26–35 years compared to those aged 16–25 years (OR immediate regret—0.40 95% CI 0.16–1.01) (OR current regret—0.22 95% CI 0.07 – 0.71) and was not associated with the HIVST result. There was limited evidence that reports of verbal abuse perpetrated by clients in the week following HIVST use were greater than when there was no testing in the preceding week. There was no evidence for increases in any other social harms. There was some evidence of coercion to test, most commonly initiated by the peer distributor. Conclusions: Little evidence was found that the peer distribution model was associated with increased levels of social harms, however programmes aimed at reaching FSW need to carefully consider possible unintended consequences of their service delivery approaches, including the potential for peer distributors to coerce individuals to test or disclose their test results and alternative distribution models may need to be considered. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. Lessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation.
- Author
-
Simwinga, Musonda, Gwanu, Lwiindi, Hensen, Bernadette, Sigande, Lucheka, Mainga, Mwami, Phiri, Thokozile, Mwanza, Eliphas, Kabumbu, Mutale, Mulubwa, Chama, Mwenge, Lawrence, Bwalya, Chiti, Kumwenda, Moses, Mubanga, Ellen, Mee, Paul, Johnson, Cheryl C., Corbett, Elizabeth L., Hatzold, Karin, Neuman, Melissa, Ayles, Helen, and Taegtmeyer, Miriam
- Abstract
Background Although Zambia has integrated HIV-self-testing (HIVST) into its Human Immunodefciency Virus (HIV) regulatory frameworks, few best practices to optimize the use of HIV self-testing to increase testing coverage have been documented. We conducted a prospective case study to understand contextual factors guiding implementation of four HIVST distribution models to inform scale-up in Zambia. Methods We used the qualitative case study method to explore user and provider experiences with four HIVST distribution models (two secondary distribution models in Antenatal Care (ANC) and Antiretroviral Therapy (ART) clinics, community-led, and workplace) to understand factors infuencing HIVST distribution. Participants were purposefully selected based on their participation in HIVST and on their ability to provide rich contextual experience of the distribution models. Data were collected using observations (n=31), group discussions (n=10), and in-depth interviews (n=77). Data were analyzed using the thematic approach and aligned to the four Consolidated Framework for Implementation Research (CFIR) domains. Results Implementation of the four distribution models was infuenced by an interplay of outer and inner setting factors. Inadequate compensation and incentives for distributors may have contributed to distributor attrition in the community-led and workplace HIVST models. Stockouts, experienced at the start of implementation in the secondary-distribution and community-led distribution models often disrupted distribution. The existence of policy and practices aided integration of HIVST in the workplace. External factors complimented internal factors for successful implementation. For instance, despite distributor attrition leading to excessive workload, distributors often multi-tasked to keep up with demand for kits, even though distribution points were geographically widespread in the workplace, and to a less extent in the community-led models. Use of existing communication platforms such as lunchtime and safety meetings to promote and distribute kits, peers to support distributors, reduction in trips by distributors to replenish stocks, increase in monetary incentives and reorganisation of stakeholder roles proved to be good adaptations. Conclusion HIVST distribution was infuenced by a combination of contextual factors in variable ways. Understanding how the factors interacted in real world settings informed adaptations to implementation devised to minimize disruptions to distribution. [ABSTRACT FROM AUTHOR]
- Published
- 2024
31. Cost-Effectiveness of Community-based Human Immunodeficiency Virus Self-Testing in Blantyre, Malawi
- Author
-
Maheswaran, Hendramoorthy, Clarke, Aileen, MacPherson, Peter, Kumwenda, Felistas, Lalloo, David G., Corbett, Elizabeth L., and Petrou, Stavros
- Published
- 2018
32. Urinary Lipoarabinomannan Detection and Disseminated Nontuberculous Mycobacterial Disease
- Author
-
Gupta-Wright, Ankur, Kerkhoff, Andrew D., Meintjes, Graeme, and Corbett, Elizabeth L.
- Published
- 2018
33. Who is reached by HIV self-testing? Individual factors associated with self-testing within a community-based programme in rural Malawi
- Author
-
Indravudh, Pitchaya P., Hensen, Bernadette, Nzawa, Rebecca, Chilongosi, Richard, Nyirenda, Rose, Johnson, Cheryl C., Hatzold, Karin, Fielding, Katherine, Corbett, Elizabeth L, and Neuman, Melissa
- Published
- 2020
- Full Text
- View/download PDF
34. The impact and cost-effectiveness of community-based HIV self-testing in sub-Saharan Africa: a health economic and modelling analysis
- Author
-
Cambiano, Valentina, Johnson, Cheryl C., Hatzold, Karin, Terris-Prestholt, Fern, Maheswaran, Hendy, Thirumurthy, Harsha, Figueroa, Carmen, Cowan, Frances M., Sibanda, Euphemia L., Ncube, Getrude, Revill, Paul, Baggaley, Rachel C., Corbett, Elizabeth L., and Phillips, Andrew
- Subjects
Health care costs -- Economic aspects ,Highly active antiretroviral therapy -- Usage ,HIV infections -- Diagnosis ,HIV tests -- Usage ,Health - Abstract
Introduction: The prevalence of undiagnosed HIV is declining in Africa, and various HIV testing approaches are finding lower positivity rates. In this context, the epidemiological impact and cost-effectiveness of community-based HIV self-testing (CB-HIVST) is unclear. We aimed to assess this in different sub-populations and across scenarios characterized by different adult HIV prevalence and antiretroviral treatment programmes in sub-Saharan Africa. Methods: The synthesis model was used to address this aim. Three sub-populations were considered for CB-HIVST: (i) women having transactional sex (WTS); (ii) young people (15 to 24 years); and (iii) adult men (25 to 49 years). We assumed uptake of CB-HIVST similar to that reported in epidemiological studies (base case), or assumed people use CB-HIVST only if exposed to risk (condomless sex) since last HIV test. We also considered a five-year time-limited CB-HIVST programme. Cost-effectiveness was defined by an incremental cost-effectiveness ratio (ICER; cost-per-disability-adjusted life-year (DALY) averted) below US$500 over a time horizon of 50 years. The efficiency of targeted CB-HIVST was evaluated using the number of additional tests per infection or death averted. Results: In the base case, targeting adult men with CB-HIVST offered the greatest impact, averting 1500 HIV infections and 520 deaths per year in the context of a simulated country with nine million adults, and impact could be enhanced by linkage to voluntary medical male circumcision (VMMC). However, the approach was only cost-effective if the programme was limited to five years or the undiagnosed prevalence was above 3%. CB-HIVST to WTS was the most cost-effective. The main drivers of cost-effectiveness were the cost of CB-HIVST and the prevalence of undiagnosed HIV. All other CB-HIVST scenarios had an ICER above US$500 per DALY averted. Conclusions: CB-HIVST showed an important epidemiological impact. To maximize population health within a fixed budget, CB-HIVST needs to be targeted on the basis of the prevalence of undiagnosed HIV, sub-population and the overall costs of delivering this testing modality. Linkage to VMMC enhances its cost-effectiveness. Keywords: HIV testing, community-based HIV self-testing; cost-effectiveness; mathematical modelling; HIV; benefits and cost, 1 | INTRODUCTION The ambitious UNAIDS targets, set in 2014, of diagnosing 90% of people living with HIV, having 90% of those diagnosed on antiretroviral treatment (ART) and having virological [...]
- Published
- 2019
- Full Text
- View/download PDF
35. The Self-Testing AfRica (STAR) Initiative: accelerating global access and scale-up of HIV self-testing
- Author
-
Ingold, Heather, Mwerinde, Ombeni, Ross, Anna Laura, Leach, Ross, Corbett, Elizabeth L., Hatzold, Karin, Johnson, Cheryl C., Ncube, Getrude, Nyirenda, Rose, and Baggaley, Rachel C.
- Subjects
HIV infections -- Prevention -- Patient outcomes -- Diagnosis ,HIV tests -- Usage ,Medical research ,Health - Abstract
Introduction: HIV self-testing (HIVST) was first proposed as an additional option to standard HIV testing services in the 1980s. By 2015, two years after the first HIVST kit was approved for the American market and the year in which Unitaid invested in the 'HIV Self-Testing AfRica (STAR) Initiative,' HIVST remained unexplored with negligible access in low- and middle-income countries (LMIC). However, rapid progress had been made. This commentary outlines the interlinked market, regulatory and policy barriers that had inhibited product development and kept HIVST out of LMIC policy. We detail the components of STAR that enabled rapid HIVST scale-up, including critical investments in implementation, research, market forecasting, and engagement with manufacturers and regulators. Discussion: The STAR Initiative has generated crucial information about how to distribute HIVST products effectively, ethically and efficiently. Service delivery models range from clinic-based distribution to workplace and partner-delivered approaches to reach first-time male testers, to community outreach to sex workers and general population 'hotspots.' These data directly informed supportive policy, notably the 2016 WHO guidelines strongly recommending HIVST as an additiona testing approach, and regulatory change through support for WHO prequalification of the first HIVST kit in 2017. In July 2015, only two countries had national HIVST policies and were implementing HIVST. Three years later, 59 countries have policies, actively implemented in 28, with an additional 53 countries reporting policies under development. By end-November 2018 several quality-assured HIVST products had been registered, including two WHO prequalified tests. STAR Initiative countries have drafted regulations governing in vitro diagnostics, including HIVST products. With enabling policies, pre-qualification and regulations in place, donor procurement of kits has increased rapidly, to a forecasted estimate of 16 million HIVST kits procured by 2020. Conclusions: The STAR Initiative provided a strong foundation to introduce HIVST in LMICs and allow for rapid scale-up based on the wealth of multi-country evidence gathered. Together with sustained coordination and acceleration of market development work, HIVST can help address the testing gap and provide a focused and cost-effective means to expand access to treatment and prevention services. Keywords: HIV testing; HIV self-testing; market shaping; scale-up; prevention; linkage to care; cost effectiveness, 1 | INTRODUCTION HIV testing is the gateway to treatment and care and expanded prevention coverage. The first of the United Nations' 90-90-90 Fast Track targets to end the HIV [...]
- Published
- 2019
- Full Text
- View/download PDF
36. Exploring social harms during distribution of HIV self-testing kits using mixed-methods approaches in Malawi
- Author
-
Kumwenda, Moses K., Johnson, Cheryl C., Choko, Augustine T., Lora, Wezzie, Sibande, Wakumanya, Sakala, Doreen, Indravudh, Pitchaya, Chilongosi, Richard, Baggaley, Rachael C., Nyirenda, Rose, Taegtmeyer, Miriam, Hatzold, Karin, Desmond, Nicola, and Corbett, Elizabeth L.
- Subjects
Clinical trials -- Analysis ,HIV infections -- Diagnosis ,HIV tests -- Usage ,Health - Abstract
Introduction: HIV self-testing (HIVST) provides couples and individuals with a discreet, convenient and empowering testing option. As with all HIV testing, potential harms must be anticipated and mitigated to optimize individual and public health benefits. Here, we describe social harms (SHs) reported during HIVST implementation in Malawi, and propose a framework for grading and responding to harms, according to their severity. Methods: We report findings from six HIVST implementation studies in Malawi (2011 to 2017) that included substudies investigating SH reports. Qualitative methods included focus group discussions, in-depth interviews and critical incident interviews. Earlier studies used intensive quantitative methods (post-test questionnaires for intimate partner violence, household surveys, investigation of all deaths in HIVST communities). Later studies used post-marketing reporting with/without community engagement. Pharmacovigilance methodology (whereby potentially life-threatening/changing events are defined as 'serious') was used to grade SH severity, assuming more complete passive reporting for serious events. Results: During distribution of 175,683 HIVST kits, predominantly under passive SH reporting, 25 serious SHs were reported from 19 (0.011%) self-testers, including 15 partners in eight couples with newly identified HIV discordancy, and one perinatally infected adolescent. There were no deaths or suicides. Marriage break-up was the most commonly reported serious SH (sixteen individuals; eight couples), particularly among serodiscordant couples. Among new concordant HIV-positive couples, blame and frustration was common but rarely (one episode) led to serious SHs. Among concordant HIV-negative couples, increased trust and stronger relationships were reported. Coercion to test or disclose was generally considered 'well-intentioned' within established couples. Women felt empowered and were assertive when offering HIVST test kits to their partners. Some women who persuaded their partner to test, however, did report SHs, including verbal or physical abuse and economic hardship. Conclusions: After more than six years of large-scale HIVST implementation and in-depth investigation of SHs in Malawi, we identified approximately one serious reported SH per 10,000 HIVST kits distributed, predominantly break-up of married serodiscordant couples. Both 'active' and 'passive' reporting systems identified serious SH events, although with more complete capture by 'active' systems. As HIVST is scaled-up, efforts to support and further optimize community-led SH monitoring should be prioritized alongside HIVST distribution. Keywords: HIV/AIDS; HIV self-test; HIV testing; social harms; Malawi, 1 | INTRODUCTION Despite concerted efforts to scale-up HIV testing services, in 2017, approximately 25% of people with HIV remain undiagnosed [1]. Globally, men, young people and key populations are [...]
- Published
- 2019
- Full Text
- View/download PDF
37. Economic cost analysis of door-to-door community-based distribution of HIV self-test kits in Malawi, Zambia and Zimbabwe
- Author
-
Mangenah, Collin, Mwenge, Lawrence, Sande, Linda, Ahmed, Nurilign, d'Elbee, Marc, Chiwawa, Progress, Chigwenah, Tariro, Kanema, Sarah, Mutseta, Miriam N., Nalubamba, Mutinta, Chilongosi, Richard, Indravudh, Pitchaya, Sibanda, Euphemia L., Neuman, Melissa, Ncube, Getrude, Ong, Jason J., Mugurungi, Owen, Hatzold, Karin, Johnson, Cheryl C., Ayles, Helen, Corbett, Elizabeth L., Cowan, Frances M., Maheswaran, Hendramoorthy, and Terris-Prestholt, Fern
- Subjects
Health care costs -- Economic aspects ,HIV tests -- Usage ,Health - Abstract
Introduction: HIV self-testing (HIVST) is recommended by the World Health Organization in addition to other testing modalities to increase uptake of HIV testing, particularly among harder-to-reach populations. This study provides the first empirica evidence of the costs of door-to-door community-based HIVST distribution in Malawi, Zambia and Zimbabwe. Methods: HIVST kits were distributed door-to-door in 71 sites across Malawi, Zambia and Zimbabwe from June 2016 to May 2017. Programme expenditures, supplemented by on-site observation and monitoring and evaluation data were used to estimate total economic and unit costs of HIVST distribution, by input and site. Inputs were categorized into start-up, capital and recurrent costs. Sensitivity and scenario analyses were performed to assess the impact of key parameters on unit costs. Results: In total, 152,671, 103,589 and 93,459 HIVST kits were distributed in Malawi, Zambia and Zimbabwe over 12, 11 and 10 months respectively. Across these countries, 43% to 51% of HIVST kits were distributed to men. The average cost per HIVST kit distributed was US$8.15, US$16.42 and US$13.84 in Malawi, Zambia and Zimbabwe, respectively, with pronounced intersite variation within countries driven largely by site-level fixed costs. Site-level recurrent costs were 70% to 92% of full costs and 20% to 62% higher than routine HIV testing services (HTS) costs. Personnel costs contributed from 26% to 52% of total costs across countries reflecting differences in remuneration approaches and country GDP. Conclusions: These early door-to-door community HIVST distribution programmes show large potential, both for reaching untested populations and for substantial economies of scale as HIVST programmes scale-up and mature. From a societal perspective, the costs of HIVST appear similar to conventional HTS, with the higher providers' costs substantially offsetting user costs. Future approaches to minimizing cost and/or maximize testing coverage could include unpaid door-to-door community-led distribution to reach end-users and integrating HIVST into routine clinical services via direct or secondary distribution strategies with lower fixed costs. Keywords: HIV self-testing; costs and cost analysis; community; Malawi; Zambia; Zimbabwe, 1 | INTRODUCTION In East and Southern Africa, freely available HIV services have led to a 42% reduction in AIDS-related deaths between 2010 and 2016. Despite such gains, 24% of [...]
- Published
- 2019
- Full Text
- View/download PDF
38. HIV self-testing: breaking the barriers to uptake of testing among men and adolescents in sub-Saharan Africa, experiences from STAR demonstration projects in Malawi, Zambia and Zimbabwe
- Author
-
Hatzold, Karin, Gudukeya, Stephano, Mutseta, Miriam N., Chilongosi, Richard, Nalubamba, Mutinta, Nkhoma, Chiwawa, Munkombwe, Hambweka, Munjoma, Malvern, Mkandawire, Phillip, Mabhunu, Varaidzo, Smith, Gina, Madidi, Ngonidzashe, Ahmed, Hussein, Kambeu, Taurai, Stankard, Petra, Johnson, Cheryl C., and Corbett, Elizabeth L.
- Subjects
HIV infections -- Diagnosis ,HIV tests -- Usage ,Youth -- Health aspects ,Health - Abstract
Introduction: Social, structural and systems barriers inhibit uptake of HIV testing. HIV self-testing (HIVST) has shown promising uptake by otherwise underserved priority groups including men, young people and first-time testers. Here, we use characteristics of HIVST kit recipients to investigate delivery to these priority groups during HIVST scale-up in three African countries. Methods: Kit distributors collected individual-level age, sex and testing history from all clients. These data were aggregated and analysed by country (Malawi, Zambia and Zimbabwe) for five distribution models: local community-based distributor (CBD: door-to-door, street and local venues), workplace distribution (WD), integration into HIV testing services (IHTS), or pubic health facilities (IPHF) and during demand creation for voluntary male medical circumcision (VMMC). Used kits were collected and re-read from CBD and IHTS recipients. Results: Between May 2015 and July 2017, 628,705 HIVST kits were distributed in Malawi (172,830), Zambia (190,787) and Zimbabwe (265,091). Community-based models, the first to be established, accounted for 519,658 (82.7%) of kits distributed, with 275,419 (53.0%) used kits returned. Subsequent model diversification delivered 54,453 (8.7%) test-kits through IHTS, 23,561 (3.7%) through VMMC, 21,183 (3.4%) through IPHF and 9850 (1.7%) through WD. Men took 294,508 (48.2%) kits, and 263,073 (43.1%) went to young people (16 to 24 years). A higher proportion of male self-testers (65,577; 22.3%) were first-time testers than women (54,096; 17.1%) with this apparent in Zimbabwe (16.2% vs. 11.4%), Zambia (25.4% vs. 17.7%) and Malawi (27.9% vs. 25.9%). The highest proportions of first-time testers were in young (16 to 24 years) and older (>50 years) men (country-ranges: 18.7% to 35.9% and 13.8% to 26.8% respectively). Most IHTS clients opted for HIVST in preference to standard HTS in each of 12 delivery sites, with those selecting HIVST having lower HIV prevalence, potentially due to self-selection. Conclusions: HIVST delivered at scale using several different models reached a high proportion of men, young people and first-time testers in Malawi, Zambia and Zimbabwe, some of whom may not have tested otherwise. As men and young people have limited uptake under standard facility-and community-based HIV testing, innovative male- and youth-sensitive approaches like HIVST may be essential to reaching UNAIDS fast-track targets for 2020. Keywords: HIV self-testing; HIV testing; men; adolescents; stigma; Malawi; Zambia; Zimbabwe, 1 | INTRODUCTION In 2016, 36.7 million people were living with HIV (PLHIV), with 1.8 million new HIV infections and one million HIV/AIDS-related deaths [1]. Despite substantial progress toward the [...]
- Published
- 2019
- Full Text
- View/download PDF
39. Applying user preferences to optimize the contribution of HIV self-testing to reaching the 'first 90' target of UNAIDS Fast-track strategy: results from discrete choice experiments in Zimbabwe
- Author
-
Sibanda, Euphemia L., d'Elbee, Marc, Maringwa, Galven, Ruhode, Nancy, Tumushime, Mary, Madanhire, Claudius, Ong, Jason J., Indravudh, Pitchaya, Watadzaushe, Constancia, Johnson, Cheryl C., Hatzold, Karin, Taegtmeyer, Miriam, Hargreaves, James R., Corbett, Elizabeth L., Cowan, Frances M., and Terris-Prestholt, Fern
- Subjects
HIV infections -- Patient outcomes -- Diagnosis ,HIV tests -- Usage -- Evaluation ,Health - Abstract
Introduction: New HIV testing strategies are needed to reach the United Nations' 90-90-90 target. HIV self-testing (HIVST) can increase uptake, but users' perspectives on optimal models of distribution and post-test services are uncertain. We used discrete choice experiments (DCEs) to explore the impact of service characteristics on uptake along the testing cascade. Methods: DCEs are a quantitative survey method that present respondents with repeated choices between packages of service characteristics, and estimate relative strengths of preferences for service characteristics. From June to October 2016, we embedded DCEs within a population-based survey following door-to-door HIVST distribution by community volunteers in two rural Zimbabwean districts: one DCE addressed HIVST distribution preferences; and the other preferences for linkage to confirmatory testing (LCT) following self-testing. Using preference coefficients/utilities, we identified key drivers of uptake for each service and simulated the effect of changes of outreach and static/public clinics' characteristics on LCT. Results: Distribution and LCT DCEs surveyed 296/329 (90.0%) and 496/594 (83.5%) participants; 81.8% and 84.9% had ever-tested, respectively. The strongest distribution preferences were for: (1) free kits - a $1 increase in the kit price was associated with a disutility (U) of --2.017; (2) door-to-door kit delivery (U = +1.029) relative to collection from public/outreach clinic; (3) telephone helpline for pretest support relative to in-person or no support (U = +0.415); (4) distributors from own/local village (U = +0.145) versus those from external communities. Participants who had never HIV tested valued phone helpines more than those previously tested. The strongest LCT preferences were: (1) immediate antiretroviral therapy (ART) availability: U = +0.614 and U = +1.052 for public and outreach clinics, respectively; (2) free services: a $1 user fee increase decreased utility at public (U = -0.381) and outreach clinics (U = -0.761); (3) proximity of clinic (U = -0.38 per hour walking). Participants reported willingness to link to either location; but never-testers were more averse to LCT. Simulations showed the importance of availability of ART: ART unavailability at public clinics would reduce LCT by 24%. Conclusions: Free HIVST distribution by local volunteers and immediately available ART were the strongest relative preferences identified. Accommodating LCT preferences, notably ensuring efficient provision of ART, could facilitate 'resistant testers' to test while maximizing uptake of post-test services. Keywords: discrete choice experiments; HIV self-testing; HIV testing; Zimbabwe; HIV; preferences, 1 | INTRODUCTION HIV testing is an important entry point for uptake of prevention, treatment and care services. The United Nations 90-90-90 targets are that by 2020, 90% of people [...]
- Published
- 2019
- Full Text
- View/download PDF
40. Re-reading of OraQuick HIV-1/2 rapid antibody test results: quality assurance implications for HIV self-testing programmes
- Author
-
Watson, Victoria, Dacombe, Russell J., Williams, Christopher, Edwards, Thomas, Adams, Emily R., Johnson, Cheryl C., Mutseta, Miriam N., Corbett, Elizabeth L., Cowan, Frances M., Ayles, Helen, Hatzold, Karin, MacPherson, Peter, and Taegtmeyer, Miriam
- Subjects
HIV infections -- Diagnosis ,HIV tests -- Usage ,Health policy -- Analysis ,Health - Abstract
Introduction: Scale-up of HIV self-testing (HIVST) will play a key role in meeting the United Nation's 90-90-90 targets. Delayed re-reading of used HIVST devices has been used by early implementation studies to validate the performance of self-test kits and to estimate HIV positivity among self-testers. We investigated the stability of results on used devices under controlled conditions to assess its potential as a quality assurance approach for HIVST scale-up. Methods: 444 OraQuick[R] HIV-1/2 rapid antibody tests were conducted using commercial plasma from two HIV-positive donors and HIV-negative plasma (high-reactive n = 148, weak-reactive n = 148 and non-reactive n = 148) and incubated them for six months under four conditions (combinations of high and low temperatures and humidity). Devices were reread daily for one week, weekly for one subsequent month and then once a month by independent readers unaware of the previous results. We used multistage transition models to investigate rates of change in device results, and between storage conditions. Results and discussion: There was a high incidence of device instability. Forty-three (29%) of 148 initially non-reactive results became false weak-reactive results. These changes were observed across all incubation conditions, the earliest on Day 4 (n = 9 kits). No initially HIV-reactive results changed to a non-reactive result. There were no significant associations between storage conditions and hazard of results transition. We observed substantial statistical agreement between independent re-readers over time (agreement range: 0.74 to 0.96). Conclusions: Delayed re-reading of used OraQuick[R] HIV-1/2 rapid antibody tests is not currently a valid methodologica approach to quality assurance and monitoring as we observed a high incidence (29%) of true non-reactive tests changing to false weak-reactive and therefore its use may overestimate true HIV positivity. Keywords: HIV self-testing; Quality assurance; Delayed re-reading; Visual stability; False reactive; Misdiagnosis; HIV testing, 1 | INTRODUCTION HIV self-testing (HIVST) is being scaled-up using a variety of distribution models throughout Africa, the Americas, Asia and Europe [1-4]. No clear monitoring and evaluation or external [...]
- Published
- 2019
- Full Text
- View/download PDF
41. Regulation of HIV self-testing in Malawi, Zambia and Zimbabwe: a qualitative study with key stakeholders
- Author
-
Dacombe, Russell J., Watson, Victoria, Nyirenda, Lot, Madanhire, Claudius, Simwinga, Musonda, Chepuka, Lignet, Johnson, Cheryl C., Corbett, Elizabeth L., Hatzold, Karin, and Taegtmeyer, Miriam
- Subjects
HIV infections -- Diagnosis ,HIV tests -- Usage ,Health - Abstract
Introduction: HIV self-testing (HIVST) is being introduced as a new way for more undiagnosed people to know their HIV status. As countries start to implement HIVST, assuring the quality and regulating in vitro diagnostics, including HIVST, are essential. We aimed to document the emerging regulatory landscape and perceptions of key stakeholders involved in HIVST policy and regulation prior to implementation in three low- and middle-income countries. Methods: Between April and August 2016, we conducted semi-structured interviews in Malawi, Zambia and Zimbabwe to understand the relationships between different stakeholders on their perceptions of current and future HIVST regulation and the potential impact on implementation. We purposively sampled and interviewed 66 national-level key stakeholders from the Ministry of Health and the regulatory, laboratory, logistical, donor and non-governmental sectors. We used a thematic approach to analysis with an inductively developed common coding framework to allow inter-country comparison of emerging themes. Results: In all countries, the national reference laboratory was monitoring the quality of HIVST kits entering the public sector. In Malawi, there was no legal mandate to regulate medical devices, in Zambia one regulatory body with a clear mandate had started developing regulations and in Zimbabwe the mandate to regulate was overlapping between two bodies. Stakeholders indicated that they had a poor understanding of the process and requirements for HIVST regulation, as well as lack of clarity and coordination between organizational roles. The need for good collaboration between sectors, a strong post-market surveilance model for HIVST and technical assistance to develop regulators capacity was noted as priorities. Key informants identified technical working groups as a potential way collaboration could be improved upon to accelerate the regulation of HIVST. Conclusion: Regulation of in vitro diagnostic devices, including HIVST, is now being recognized as important by regulators after a regional focus on pharmaceuticals. HIVST is providing an opportunity for each country to develop similar regulations to others in the region leading to a more coherent regulatory environment for the introduction of new devices. Keywords: quality assurance; policy; in vitro diagnostics; post market; implementation; harmonization, 1 | INTRODUCTION The World Health Organization (WHO) defines HIV self-testing (HIVST) as 'a process in which a person collects his or her own specimen (oral fluid or blood) and [...]
- Published
- 2019
- Full Text
- View/download PDF
42. Ability to understand and correctly follow HIV self-test kit instructions for use: applying the cognitive interview technique in Malawi and Zambia
- Author
-
Simwinga, Musonda, Kumwenda, Moses K., Dacombe, Russell J., Kayira, Lusungu, Muzumara, Agness, Johnson, Cheryl C., Indravudh, Pitchaya, Sibanda, Euphemia L., Nyirenda, Lot, Hatzold, Karin, Corbett, Elizabeth L., Ayles, Helen, and Taegtmeyer, Miriam
- Subjects
HIV infections -- Diagnosis ,HIV tests -- Usage ,Medical research ,Health - Abstract
Introduction: The ability to achieve an accurate test result and interpret it correctly is critical to the impact and effectiveness of HIV self-testing (HIVST). Simple and easy-to-use devices, instructions for use (IFU) and other support tools have been shown to be key to good performance in sub-Saharan Africa and may be highly contextual. The objective of this study was to explore the utility of cognitive interviewing in optimizing the local understanding of manufacturers' IFUs to achieve an accurate HIVST result. Methods: Functionally literate and antiretroviral therapy-naive participants were purposefully selected between May 2016 and June 2017 to represent intended users of HIV self-tests from urban and rural areas in Malawi and Zambia. Participants were asked to follow IFUs for HIVST. We then conducted cognitive interviews and observed participants while they attempted to complete the HIVST steps using a structured guide, which mirrored the steps in the IFU. Qualitative data were analysed using a thematic approach. Results: Of a total of 61 participants, many successfully performed most steps in the IFU. Some had difficulties in understanding these and made errors, which could have led to incorrect test results, such as incorrect use of buffer and reading the results prematurely. Participants with lower levels of literacy and inexperience with standard pictorial images were more likely to struggle with IFUs. Difficulties tended to be more pronounced among those in rural settings. Ambiguous terms and translations in the IFU, unfamiliar images and symbols, and unclear order of the steps to be followed were most commonly linked to errors and lower comprehension among participants. Feedback was provided to the manufacturer on the findings, which resulted in further optimization of IFUs. Conclusions: Cognitive interviewing identifies local difficulties in conducting HIVST from manufacturer-translated IFUs. It is a useful and practical methodology to optimize IFUs and make them more understandable. Keywords: HIV self-test; performance; in vitro diagnosis; instructions for use; Zambia; Malawi, 1 | INTRODUCTION HIV self-testing (HIVST) is increasingly being introduced as a testing approach recommended by the World Health Organization (WHO) to reach those who may not otherwise test [1,2]. [...]
- Published
- 2019
- Full Text
- View/download PDF
43. The Role of Human Immunodeficiency Virus–Associated Vasculopathy in the Etiology of Stroke
- Author
-
Benjamin, Laura A., Allain, Theresa J., Mzinganjira, Henry, Connor, Myles D., Smith, Colin, Lucas, Sebastian, Joekes, Elizabeth, Kampondeni, Sam, Chetcuti, Karen, Turnbull, Ian, Hopkins, Mark, Kamiza, Steve, Corbett, Elizabeth L., Heyderman, Robert S., and Solomon, Tom
- Published
- 2017
44. Using HIV self-testing to increase the affordability of community-based HIV testing services
- Author
-
d’Elbée, Marc, Makhetha, Molemo Charles, Jubilee, Makhahliso, Taole, Matee, Nkomo, Cyril, Machinda, Albert, Tlhomola, Mphotleng, Sande, Linda A., Gomez Guillen, Gabriela B., Corbett, Elizabeth L., Johnson, Cheryl C., Hatzold, Karin, Meyer-Rath, Gesine, and Terris-Prestholt, Fern
- Published
- 2020
- Full Text
- View/download PDF
45. Use and awareness of and willingness to self-test for HIV: an analysis of cross-sectional population-based surveys in Malawi and Zimbabwe
- Author
-
Johnson, Cheryl, Neuman, Melissa, MacPherson, Peter, Choko, Augustine, Quinn, Caitlin, Wong, Vincent J., Hatzold, Karin, Nyrienda, Rose, Ncube, Getrude, Baggaley, Rachel, Terris-Prestholt, Fern, and Corbett, Elizabeth L.
- Published
- 2020
- Full Text
- View/download PDF
46. Ethical issues in cluster randomized trials conducted in low- and middle-income countries: an analysis of two case studies
- Author
-
Choko, Augustine T., Roshandel, Gholamreza, Conserve, Donaldson F., Corbett, Elizabeth L., Fielding, Katherine, Hemming, Karla, Malekzadeh, Reza, and Weijer, Charles
- Published
- 2020
- Full Text
- View/download PDF
47. Using research networks to generate trustworthy qualitative public health research findings from multiple contexts
- Author
-
Nyirenda, Lot, Kumar, Meghan Bruce, Theobald, Sally, Sarker, Malabika, Simwinga, Musonda, Kumwenda, Moses, Johnson, Cheryl, Hatzold, Karin, Corbett, Elizabeth L., Sibanda, Euphemia, and Taegtmeyer, Miriam
- Published
- 2020
- Full Text
- View/download PDF
48. Computer-aided X-ray screening for tuberculosis and HIV testing among adults with cough in Malawi (the PROSPECT study): A randomised trial and cost-effectiveness analysis
- Author
-
MacPherson, Peter, Webb, Emily L., Kamchedzera, Wala, Joekes, Elizabeth, Mjoli, Gugu, Lalloo, David G., Divala, Titus H., Choko, Augustine T., Burke, Rachael M., Maheswaran, Hendramoorthy, Pai, Madhukar, Squire, S. Bertel, Nliwasa, Marriott, and Corbett, Elizabeth L.
- Subjects
Cough -- Diagnosis ,Medical care, Cost of -- Analysis ,Tuberculosis -- Diagnosis ,Computer-aided medical diagnosis -- Methods -- Economic aspects ,HIV infection -- Diagnosis ,Biological sciences - Abstract
Background Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening, including computer-aided digital chest X-ray (DCXR-CAD). Methods and findings In this open, three-arm randomised trial, adults ([greater than or equal to]18 years) with cough attending acute primary services in Malawi were randomised (1:1:1) to standard of care (SOC); oral HIV testing (HIV screening) and linkage to care; or HIV testing and linkage to care plus DCXR-CAD with sputum Xpert for high CAD4TBv5 scores (HIV-TB screening). Participants and study staff were not blinded to intervention allocation, but investigator blinding was maintained until final analysis. The primary outcome was time to TB treatment. Secondary outcomes included proportion with same-day TB treatment; prevalence of undiagnosed/untreated bacteriologically confirmed TB on day 56; and undiagnosed/untreated HIV. Analysis was done on an intention-to-treat basis. Cost-effectiveness analysis used a health-provider perspective. Between 15 November 2018 and 27 November 2019, 8,236 were screened for eligibility, with 473, 492, and 497 randomly allocated to SOC, HIV, and HIV-TB screening arms; 53 (11%), 52 (9%), and 47 (9%) were lost to follow-up, respectively. At 56 days, TB treatment had been started in 5 (1.1%) SOC, 8 (1.6%) HIV screening, and 15 (3.0%) HIV-TB screening participants. Median (IQR) time to TB treatment was 11 (6.5 to 38), 6 (1 to 22), and 1 (0 to 3) days (hazard ratio for HIV-TB versus SOC: 2.86, 1.04 to 7.87), with same-day treatment of 0/5 (0%) SOC, 1/8 (12.5%) HIV, and 6/15 (40.0%) HIV-TB screening arm TB patients (p = 0.03). At day 56, 2 SOC (0.5%), 4 HIV (1.0%), and 2 HIV-TB (0.5%) participants had undiagnosed microbiologically confirmed TB. HIV screening reduced the proportion with undiagnosed or untreated HIV from 10 (2.7%) in the SOC arm to 2 (0.5%) in the HIV screening arm (risk ratio [RR]: 0.18, 0.04 to 0.83), and 1 (0.2%) in the HIV-TB screening arm (RR: 0.09, 0.01 to 0.71). Incremental costs were US$3.58 and US$19.92 per participant screened for HIV and HIV-TB; the probability of cost-effectiveness at a US$1,200/quality-adjusted life year (QALY) threshold was 83.9% and 0%. Main limitations were the lower than anticipated prevalence of TB and short participant follow-up period; cost and quality of life benefits of this screening approach may accrue over a longer time horizon. Conclusions DCXR-CAD with universal HIV screening significantly increased the timeliness and completeness of HIV and TB diagnosis. If implemented at scale, this has potential to rapidly and efficiently improve TB and HIV diagnosis and treatment. Trial registration clinicaltrials.gov NCT03519425., Author(s): Peter MacPherson 1,2,3,*, Emily L. Webb 4, Wala Kamchedzera 2, Elizabeth Joekes 1, Gugu Mjoli 5, David G. Lalloo 1, Titus H. Divala 2,3,6, Augustine T. Choko 1,2, Rachael [...]
- Published
- 2021
- Full Text
- View/download PDF
49. What is the optimum time to start antiretroviral therapy in people with HIV and tuberculosis coinfection? A systematic review and meta‐analysis
- Author
-
Burke, Rachael M., Rickman, Hannah M., Singh, Vindi, Corbett, Elizabeth L., Ayles, Helen, Jahn, Andreas, Hosseinipour, Mina C., Wilkinson, Robert J., and Macpherson, Peter
- Subjects
Comorbidity -- Drug therapy -- Complications and side effects ,Highly active antiretroviral therapy -- Methods -- Complications and side effects -- Comparative analysis ,Tuberculosis -- Drug therapy -- Patient outcomes ,HIV patients -- Drug therapy ,HIV infection -- Drug therapy -- Patient outcomes ,Health - Abstract
: Background: HIV and tuberculosis are frequently diagnosed concurrently. In March 2021, World Health Organization recommended that antiretroviral therapy (ART) should be started within two weeks of tuberculosis treatment start, at any CD4 count. We assessed whether earlier ART improved outcomes in people with newly diagnosed HIV and tuberculosis. Methods: We did a systematic review by searching nine databases for trials that compared earlier ART to later ART initiation in people with HIV and tuberculosis. We included studies published from database inception to 12 March 2021. We compared ART within four weeks versus ART more than four weeks after TB treatment, and ART within two weeks versus ART between two and eight weeks, and stratified analysis by CD4 count. The main outcome was death; secondary outcomes included IRIS and AIDS‐defining events. We pooled effect estimates using random effects meta‐analysis. Results and discussion: We screened 2468 abstracts, and identified nine trials. Among people with all CD4 counts, there was no difference in mortality by earlier ART (≤4 week) versus later ART (>4 week) (risk difference [RD] 0%, 95% confidence interval [CI] −2% to +1%). Among people with CD4 count ≤50 cells/mm[sup.3], earlier ART (≤4 weeks) reduced risk of death (RD −6%, −10% to −1%). Among people with all CD4 counts earlier ART (≤4 weeks) increased the risk of IRIS (RD +6%, 95% CI +2% to +10%) and reduced the incidence of AIDS‐defining events (RD −2%, 95% CI −4% to 0%). Results were similar when trials were restricted to the four trials which permitted comparison of ART within two weeks to ART between two and eight weeks. Trials were conducted between 2004 and 2014, before recommendations to treat HIV at any CD4 count or to rapidly start ART in people without TB. No trials included children or pregnant women. No trials included integrase inhibitors in ART regimens. Discussion: Earlier ART did not alter risk of death overall among people living with HIV who had TB disease. For logistical and patient preference reasons, earlier ART initiation for everyone with TB and HIV may be preferred to later ART., Introduction Tuberculosis (TB) is the most important cause of morbidity and mortality among people living with HIV (PLHIV) globally [1,2]. All people with TB should be offered testing for HIV [...]
- Published
- 2021
- Full Text
- View/download PDF
50. Disparities in access to diagnosis and care in Blantyre, Malawi, identified through enhanced tuberculosis surveillance and spatial analysis
- Author
-
MacPherson, Peter, Khundi, McEwen, Nliwasa, Marriott, Choko, Augustine T., Phiri, Vincent K., Webb, Emily L., Dodd, Peter J., Cohen, Ted, Harris, Rebecca, and Corbett, Elizabeth L.
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.