Liu, Ga, Bao, Shengfei, Shi, Jiahao, Xie, Chunyu, Liao, Fuying, Wang, Lingshuang, Zheng, Fan, Reis, Rui L., Kundu, Subhas C., Xiao, Bo, Yang, Xiao, and Duan, Lian
A novel cationic pyrimidine-modified conjugated microporous polymer (BPyMe-CMP) has excellent photoelectric effect, which can produce ROS with the assistance of visible light. BPyMe-CMP possesses bioactivities to kill bacteria, adjust macrophage polarization, promote angiogenesis, and accelerate cell migration, which promotes wound healing. [Display omitted] • A novel cationic pyrimidine-modified conjugated microporous polymer (BPyMe-CMP) was prepared. • BPyMe-CMP exhibited outstanding antibacterial ability against drug-resistant bacteria. • BPyMe-CMP promoted fibroblast migration, angiogenesis and M2 macrophage polarization to inhibit inflammation. • BPyMe-CMP exhibited great promise for MRSA infected wound healing. Pathogenic bacterial invasion leads to severe inflammation that hinders wound healing, and it has become a major medical threat worldwide. Photodynamic therapy (PDT) has emerged as a promising strategy for treating microbial infection; however, developing a dressing with PDT effect and excellent biological functions poses a formidable challenge. Herein, a novel cationic pyrimidine-modified conjugated microporous polymer, BPyMe-CMP, was rationally designed and synthesized via a Sonogashira-Hagiwara and S N2 substitution reaction. The BPyMe-CMP exhibited weak interfacial charge transfer resistance and demonstrated superior photoinducible carrier separation, thereby displaying an excellent photoelectric response. Consequently, the BPyMe-CMP could readily generate reactive oxygen species under visible light irradiation to kill bacteria. In addition to enhancing the photogenerated electron transfer process, BPyMe-CMP also provided abundant attraction sites for bacteria to reinforce the antibacterial ability. The deposition of BPyMe-CMP onto polyvinyl alcohol-modified silk fibroin (SF/PVA) film served as a wound dressing to promote healing. The in vitro and in vivo experiments revealed that the SF/PVA@BPyMe-CMP induced M2-type macrophage polarization, promoted L929 fibroblast migration, exhibited bactericidal activity, and induced angiogenesis, which synergistically accelerated the healing of methicillin-resistant Staphylococcus aureus -infected wounds. This study provides data support to advance the construction of a multi-functional wound dressing based on pyrimidination and cationization for the treatment and rapid healing of infected wounds. [ABSTRACT FROM AUTHOR]