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Your search keyword '"Coene, Peter Paul L.O."' showing total 12 results
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12 results on '"Coene, Peter Paul L.O."'

2. Feasibility, safety, and efficacy of stereotactic body radiotherapy combined with intradermal heat-killed mycobacterium obuense (IMM-101) vaccination for non-progressive locally advanced pancreatic cancer, after induction chemotherapy with (modified)FOLFIRINOX – The LAPC-2 trial

Author

van 't Land, Freek R., Latifi, Diba, Moskie, Miranda, Homs, Marjolein Y.V., Bosscha, Koop, Bonsing, Bert A., Mieog, Sven D., van der Harst, Erwin, Coene, Peter-Paul L.O., Wijsman, Jan H., van der Schelling, George P., Groot Koerkamp, Bas, Nuyttens, Joost J., and van Eijck, Casper H.J.

Published
2023
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3. GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

Author

Rakké, Yannick S., Campos Carrascosa, Lucia, van Beek, Adriaan A., de Ruiter, Valeska, van Gemerden, Rachelle S., Doukas, Michail, Doornebosch, Pascal G., Vermaas, Maarten, ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L.O., Kliffen, Mike, Grünhagen, Dirk J., Verhoef, Cornelis, IJzermans, Jan N.M., Kwekkeboom, Jaap, and Sprengers, Dave

Published
2023
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4. Trajectories of health-related quality of life and psychological distress in patients with colorectal cancer: A population-based study

Author

Beets, Geerard L., Belt, Eric J.Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L.O., de Groot, Jan Willem B., de Hingh, Ignace H.J.T., de Vos, Aad I., de Wilt, Johannes H.W., Dekker, Jan Willem T., Erdkamp, Frans L.G., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., Hoekstra, Ronald, Ijzermans, Jan N.M., Jansen, Jan, Kloppenberg, Frank W.H., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Nieboer, Peter, Peeters, Koen C.M.J., Peters, Natascha A.J.B., Polée, Marco B., Pruijt, Johannes F.M., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H.W., van der Velden, Arjan Schouten, Schrauwen, Ruud W.M., Sie, Mark P.S., Simkens, Lieke, Sommeijer, Dirkje W., Sonneveld, Dirk J.A., Spierings, Leontine E.A., Stockmann, Hein B.A.C., Talsma, Koen, ten Tije, Albert J., Terheggen, Frederiek, Tjin-A-Ton, Manuel L.R., Valkenburg-van Iersel, Liselot B.J., van Cruijsen, Hester, Velden, Ankie M.T. van der, van Dodewaard-de Jong, Joyce M., van Lent, Anja U.G., van Voorthuizen, Theo, Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F.J., Zimmerman, David D.E., Qaderi, Seyed M., van der Heijden, Joost A.G., Verhoeven, Rob H.A., and Custers, Jose A.E.

Published
2021
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5. Outcome and long-term quality of life after total pancreatectomy (PANORAMA): a nationwide cohort study

Author

van Hooft, Jeanin E., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul L.O., van Dam, Ronald M., van Dieren, Susan, Gerhards, Michael F., van Goor, Harry, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Patijn, Gijs A., Scheepers, Joris J., van der Schelling, George P., Pranger, Bobby K., Busch, Olivier, Snoek, Frank, Scholten, Lianne, Latenstein, Anouk E.J., van Eijck, Casper, Erdmann, Joris, van der Harst, Erwin, Mieog, J. Sven D., Molenaar, I. Quintus, van Santvoort, Hjalmar C., DeVries, J. Hans, and Besselink, Marc G.

Published
2019
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6. Work Ability in Patients With Stage I to IV Colon Cancer: Results of the Dutch Prospective Colorectal Cancer Cohort.

Author

Franken, Mira D., Vink, Geraldine, van Grevenstein, Wilhelmina M.U., Verkooijen, Helena M., Punt, Cornelis J.A., Koopman, Miriam, May, Anne M., Beets, Geerard L., Belt, Eric J.Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L.O., de Groot, Jan Willem B., de Hingh, Ignace H.J.T., de Vos, Aad I., de Wilt, Johannes H.W., Dekker, Jan Willem T., Erdkamp, Frans L.G., and Haringhuizen, Annebeth W.

Published
2023
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8. Confirmation of a metastasis-specific microRNA signature in primary colon cancer

Author

Coebergh Van Den Braak, Robert R.J., Sieuwerts, Anieta M., Lalmahomed, Zarina S., Smid, Marcel, Wilting, Saskia M., Bril, Sandra I., Xiang, Shanshan, Van Der Vlugt-Daane, Michelle, De Weerd, Vanja, Van Galen, Anne, Biermann, Katharina, Van Krieken, J. Han J.M., Kloosterman, Wigard P., Foekens, John A., Martens, John W.M., Ijzermans, Jan N.M., Coene, Peter Paul L.O., Dekker, Jan Willem T., Zimmerman, David D.E., Tetteroo, Geert W.M., Vles, Wouter J., Vrijland, Wietske W., and MATCH study group

Subjects
General
Abstract

The identification of patients with high-risk stage II colon cancer who may benefit from adjuvant therapy may allow the clinical approach to be tailored for these patients based on an understanding of tumour biology. MicroRNAs have been proposed as markers of the prognosis or treatment response in colorectal cancer. Recently, a 2-microRNA signature (l et-7i and miR-10b) was proposed to identify colorectal cancer patients at risk of developing distant metastasis. We assessed the prognostic value of this signature and additional candidate microRNAs in an independent, clinically well-defined, prospectively collected cohort of primary colon cancer patients including stage I-II colon cancer without and stage III colon cancer with adjuvant treatment. The 2-microRNA signature specifically predicted hepatic recurrence in the stage I-II group, but not the overall ability to develop distant metastasis. The addition of miR-30b to the 2-microRNA signature allowed the prediction of both distant metastasis and hepatic recurrence in patients with stage I-II colon cancer who did not receive adjuvant chemotherapy. Available gene expression data allowed us to associate m iR-30b expression with axon guidance and l et-7i expression with cell adhesion, migration, and motility.

Published
2018

10. Surgeon's steering behaviour towards patients to participate in a cluster randomised trial on active surveillance for oesophageal cancer: A qualitative study.

Author

de Veer, Mathijs R., Hermus, Merel, van der Zijden, Charlène J., van der Wilk, Berend J., Wijnhoven, Bas P.L., Stiggelbout, Anne M., Dekker, Jan Willem T., Coene, Peter Paul L.O., Busschbach, Jan J., van Lanschot, Jan J.B., Lagarde, Sjoerd M., and Kranenburg, Leonieke W.

Subjects
ESOPHAGEAL cancer, WATCHFUL waiting, SURGEONS, QUALITATIVE research, NEOADJUVANT chemotherapy, INVESTIGATIONAL therapies, CHEMORADIOTHERAPY
Abstract

Few studies have been conducted into how physicians use steering behaviour that may persuade patients to choose for a particular treatment, let alone to participate in a randomised trial. The aim of this study is to assess if and how surgeons use steering behaviour in their information provision to patients in their choice to participate in a stepped-wedge cluster randomised trial investigating an organ sparing treatment in (curable) oesophageal cancer (SANO trial). A qualitative study was performed. Thematic content analysis was applied to audiotaped and transcribed consultations of twenty patients with eight different oncological surgeons in three Dutch hospitals. Patients could choose to participate in a clinical trial in which an experimental treatment of 'active surveillance' (AS) was offered. Patients who did not want to participate underwent standard treatment: neoadjuvant chemoradiotherapy followed by oesophagectomy. Surgeons used various techniques to steer patients towards one of the two options, mostly towards AS. The presentation of pros and cons of treatment options was imbalanced: positive framing of AS was used to steer patients towards the choice for AS, and negative framing of AS to make the choice for surgery more attractive. Further, steering language, i.e. suggestive language, was used, and surgeons seemed to use the timing of the introduction of the different treatment options, to put more focus on one of the treatment options. Awareness of steering behaviour can help to guide physicians in more objectively informing patients on participation in future clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Impact of low skeletal muscle mass and density on short and long-term outcome after resection of stage I-III colorectal cancer.

Author

van Vugt, Jeroen L.A., Coebergh van den Braak, Robert R.J., Lalmahomed, Zarina S., Vrijland, Wietske W., Dekker, Jan W.T., Zimmerman, David D.E., Vles, Wouter J., Coene, Peter-Paul L.O., and IJzermans, Jan N.M.

Subjects
SKELETAL muscle, SURGICAL excision, COLON cancer, SURVIVAL, LOW density lipoproteins
Abstract

Background Preoperative low skeletal muscle mass and density are associated with increased postoperative morbidity in patients undergoing curative colorectal cancer (CRC) surgery. However, the long-term effects of low skeletal muscle mass and density remain uncertain. Methods Patients with stage I-III CRC undergoing surgery, enrolled in a prospective observational cohort study, were included. Skeletal muscle mass and density were measured on CT. Patients with high and low skeletal muscle mass and density were compared regarding postoperative complications, disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS). Results In total, 816 patients (53.9% males, median age 70) were included; 50.4% had low skeletal muscle mass and 64.1% low density. The severe postoperative complication rate was significantly higher in patients with low versus high skeletal muscle and density (20.9% versus 13.6%, p = 0.006; 20.0% versus 11.8%, p = 0.003). Low skeletal muscle mass (OR 1.91, p = 0.018) and density (OR 1.87, p = 0.045) were independently associated with severe postoperative complications. Ninety-day mortality was higher in patients with low skeletal muscle mass and density compared with patients with high skeletal muscle mass and density (3.6% versus 1.7%, p = 0.091; 3.4% versus 1.0%, p = 0.038). No differences in DFS were observed. After adjustment for covariates such as age and comorbidity, univariate differences in OS and CSS diminished. Conclusions Low skeletal muscle mass and density are associated with short-term, but not long-term, outcome in patients undergoing CRC surgery. These findings recommend putting more emphasis on preoperative management of patients at risk for surgical complications, but do not support benefit for long-term outcome. [ABSTRACT FROM AUTHOR]

Published
2018
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