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19,723 results on '"Cobo, A."'

1. Applying Recommendation System for Developing Programming Competencies in Children from a Non-WEIRD Context

Author

Jesennia Cárdenas-Cobo, Cristian Vidal-Silva, Lisett Arévalo, and Magali Torres

Abstract

The information society is part of current life, and algorithmic thinking and programming are relevant for everybody regardless of educational background. Today's world needs professionals with computing competencies from WEIRD (Western, Educated, Industrialized, Rich, and Democratic Societies) and non-WEIRD contexts. Traditional programming languages include syntax barriers that complicate their overall adoption and usefulness for people from a non-WEIRD context. To solve it, block-based programming languages like Scratch permit the development of programming competencies without syntax restrictions in online environments. This article presents empirical evidence of the positive impact of Scratch with the CARAMBA recommendation system for lessons and exercises proposals based on collaborative filtering of personalized learning from students' experiences. Previous experiences demonstrated that students require assistance in successfully defining sub-competencies and exercises to develop programming competencies by applying Scratch. This work shows the application of Scratch and CARAMBA in a non-WEIRD school context for developing programming competencies. Obtained results show that developing exercises with Scratch and CARAMBA motivated students' autonomy, and as well, the programming learning application increased exam scores in all the analyzed grades. Those results encourage us to continue using Scratch and CARAMBA for developing programming competencies in similar non-WEIRD contexts.

Published
2024
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3. CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Author

Skoulidis, Ferdinandos, Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Cobo, Ana Galan, Le, John T., Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Schmidt, Stephanie T., Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Pecot, Chad V., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan J., Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Woodcock, Mark G., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer M., Cummings, Amy L., Goldman, Jonathan W., Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph T., Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Kemp, Haley N., Carter, Brett, Roth, Jack A., Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Behrens, Carmen, Wistuba, Ignacio I., Zhang, Jianjun, Blumenschein, George R., Gay, Carl, Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Lee, J. Jack, Bivona, Trever G., Camidge, D. Ross, Gray, Jhannelle E., Lieghl, Natasha, Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Garon, Edward B., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Herbst, Roy S., Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Carbone, David P., Hellmann, Matthew D., Rudin, Charles M., Albacker, Lee, Mann, Helen, Zhu, Zhou, Lai, Zhongwu, Stewart, Ross, Peters, Solange, Johnson, Melissa L., Wong, Kwok K., Huang, Alan, Winslow, Monte M., Rosen, Michael J., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip, and Heymach, John V.

Published
2024
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5. Efficacy and safety of colistin plus beta-lactams for bone and joint infection caused by fluoroquinolone-resistant gram-negative bacilli: a prospective multicenter study

Author

Mancheño-Losa, Mikel, Murillo, Oscar, Benavent, Eva, Sorlí, Luisa, Riera, Melchor, Cobo, Javier, Benito, Natividad, Morata, Laura, Ribera, Alba, Sobrino, Beatriz, Fernández-Sampedro, Marta, Múñez, Elena, Bahamonde, Alberto, Barbero, José María, del Toro, Mª Dolores, Villa, Jenifer, Rigo-Bonnin, Raül, Luque, Sonia, García-Luque, Isabel, Oliver, Antonio, Esteban, Jaime, and Lora-Tamayo, Jaime

Published
2024
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6. Advanced non-squamous NSCLC with no actionable oncogenic driver in Spain: a cross-sectional descriptive analysis of data from the Thoracic Tumor Registry

Author

Carcereny, Enric, Rodriguez-Abreu, Delvys, Lopez, Rafael, Franco, Fabio, Guirado, Maria, Massutí, Bartomeu, Cobo, Manuel, Blasco, Ana, Suay, Guillermo, del Barco, Edel, Ortega, Ana Laura, Sala, Maria Angeles, Cordeiro, Patricia, Bernabé, Reyes, González Larriba, José Luís, Bosch-Barrera, Joaquim, Calzas, Julia, Casal, Joaquín, Padilla, Airam, Sánchez-Hernandez, Alfredo, and Provencio, Mariano

Published
2024
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10. Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction

Author

Esteban-Fernández, Alberto, Gómez-Otero, Inés, López-Fernández, Silvia, Santamarta, Miguel Rodríguez, Pastor-Pérez, Francisco J., Fluvià-Brugués, Paula, Pérez-Rivera, José-Ángel, López López, Andrea, García-Pinilla, José Manuel, Palomas, Juan Luis Bonilla, Bonet, Luis Almenar, Cobo-Marcos, Marta, Mateo, Virgilio Martínez, Llergo, Javier Torres, Fernández, Vanesa Alonso, Vives, Cristina Goena, de Juan Bagudá, Javier, Benedicto, Alba Maestro, de Polavieja, José Ignacio Morgado, Solla-Ruiz, Itziar, Solé-González, Eduard, Cardona, Montserrat, Olaetxea, Javier Rekondo, Cortés, Carolina Ortiz, Dosantos, Victor Martínez, López, Antonio Gámez, Amao, Elvis, Sánchez, Borja Casas, Torres, Edgardo Alania, Carrillo, Víctor Gómez, García-Fuertes, Daniel, and Ridocci-Soriano, Francisco

Published
2024
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14. Multidisciplinary approach for locally advanced non-small cell lung cancer (NSCLC): 2023 expert consensus of the Spanish Lung Cancer Group GECP

Author

Ospina, Aylen Vanessa, Bolufer Nadal, Sergio, Campo-Cañaveral de la Cruz, José Luis, González Larriba, Jose Luis, Macía Vidueira, Ivan, Massutí Sureda, Bartomeu, Nadal, Ernest, Trancho, Florentino Hernando, Álvarez Kindelán, Antonio, Del Barco Morillo, Edel, Bernabé Caro, Reyes, Bosch Barrera, Joaquim, Calvo de Juan, Virginia, Casal Rubio, Joaquin, de Castro, Javier, Cilleruelo Ramos, Ángel, Cobo Dols, Manuel, Dómine Gómez, Manuel, Figueroa Almánzar, Santiago, Garcia Campelo, Rosario, Insa Mollá, Amelia, Jarabo Sarceda, José Ramón, Jiménez Maestre, Unai, López Castro, Rafael, Majem, Margarita, Martinez-Marti, Alex, Martínez Téllez, Elisabeth, Sánchez Lorente, David, and Provencio, Mariano

Published
2024
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19. Genomic dynamics of high-risk carbapenem-resistant Klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings

Author

Nehal Adel Abdelsalam, Shahira A. ElBanna, Shaimaa F. Mouftah, José F. Cobo-Díaz, Ahmed H. Shata, Sherine M. Shawky, Reham Atteya, and Mohamed Elhadidy

Subjects
Klebsiella pneumoniae, Convergence, ESBL, Carbapenem, Hypervirulence genetic determinants, Extensive-drug resistance, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Ongoing studies have revealed the global prevalence of severe infections caused by the hypervirulent strains of Klebsiella pneumoniae (K. pneumoniae). Meanwhile, the World Health Organization and the Centers for Disease Control declared carbapenem-resistant K. pneumoniae as an urgent public health threat, requiring swift and effective action to mitigate its spread. Low- and middle-income countries are severely impacted by such devastating infectious diseases owing to the ill implementation of antimicrobial practices and infection control policies. Having both hypervirulence and carbapenemase gene determinants, the emergence of convergent hypervirulent carbapenem-resistant K. pneumoniae is now being reported worldwide. Methods In this study, we sequenced 19 carbapenemase-producing K. pneumoniae strains recovered from various clinical specimens. Additionally, we evaluated the phenotypic antimicrobial susceptibility to multiple antimicrobial classes using the VITEK2 automated system. Utilizing the sequencing data, we characterized the sequence types, serotypes, pangenome, resistance profiles, virulence profiles, and mobile genetic elements of the examined isolates. We highlighted the emergence of high-risk clones carrying hypervirulence genetic determinants among the screened isolates. Results Our findings revealed that all carbapenem-resistant isolates exhibited either extensive- or pan-drug resistance and harbored multiple variants of resistance genes spanning nearly all the antimicrobial classes. The most prevalent carbapenemase genes detected within the isolates were bla NDM−5 and bla OXA−48 . We identified high-risk clones, such as ST383-K30, ST147-K64, ST11-K15, and ST14-K2, which may have evolved into putative convergent strains by acquiring the full set of hypervirulence-associated genetic determinants (iucABCD, rmpA and/ or rmpA2, putative transporter peg-344). Additionally, this study identified ST709-K9 as a high-risk clone for the first time and uncovered that capsule types K15 and K9 carried hypervirulence genetic determinants. The most frequent Inc types found in these isolates were Col440I, IncHI1B, and Inc FII(K). Conclusion This study highlights the emergence of high-risk, extensively carbapenem-resistant K. pneumoniae strains co-carrying hypervirulence determinants in Egyptian clinical settings. This poses an imminent threat not only to Egypt but also to the global community, underscoring the urgent need for enhanced surveillance and control strategies to combat this pathogen.

Published
2024
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20. In-depth characterization of food and environmental microbiomes across different meat processing plants

Author

Coral Barcenilla, José F. Cobo-Díaz, Alba Puente, Vincenzo Valentino, Francesca De Filippis, Danilo Ercolini, Niccolò Carlino, Federica Pinto, Nicola Segata, Miguel Prieto, Mercedes López, and Avelino Alvarez-Ordóñez

Subjects
Meat, Metagenomics, Microbiome, Resistome, Virulome, Resident microbiota, Microbial ecology, QR100-130
Abstract

Abstract Background Processing environments can be an important source of pathogenic and spoilage microorganisms that cross contaminate meat and meat products. The aim of this study was to characterize the microbiome of raw materials, processing environments and end products from 19 facilities producing different meat products. Results The taxonomic profiles of the microbial communities evolved along processing, from raw materials to end products, suggesting that food contact (FC) surfaces play an important role in modulating the microbiome of final products. Some species persisted with the highest relative abundance in raw materials, food processing environments and/or in the final product, including species from the genera Pseudomonas, Staphylococcus, Brochothrix, Acinetobacter and Psychrobacter. Processing environments showed a very diverse core microbiota, partially shared with the products. Pseudomonas fragi and Pseudomonas sp. Lz4W (in all sample and facility types) and Brochothrix thermosphacta, Psychrobacter sp. and Psychrobacter sp. P11F6 (in raw materials, FC surfaces and end products) were prominent members of the core microbiota for all facilities, while Latilactobacillus sakei was found as a dominant species exclusively in end products from the facilities producing fermented sausages. Processing environments showed a higher amount of antimicrobial resistance genes and virulence factors than raw materials and end products. One thousand four hundred twenty-one medium/high-quality metagenome-assembled genomes (MAGs) were reconstructed. Of these, 274 high-quality MAGs (completeness > 90%) corresponded to 210 putative new species, mostly found in processing environments. For two relevant taxa in meat curing and fermentation processes (S. equorum and L. sakei, respectively), phylogenetic variation was observed associated with the specific processing facility under study, which suggests that specific strains of these taxa may be selected in different meat processing plants, likely contributing to the peculiar sensorial traits of the end products produced in them. Conclusions Overall, our findings provide the most detailed metagenomics-based perspective up to now of the microbes that thrive in meat, meat products and associated environments and open avenues for future research activities to better understand the microbiome functionality and potential contribution to meat quality and safety. Video Abstract

Published
2024
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21. Cost-effectiveness of sodium zirconium cyclosilicate for the treatment of hyperkalemia in patients with chronic kidney disease or heart failure in Spain

Author

Roberto Alcázar-Arroyo, María G Crespo-Leiro, Jordi Bover, Juan Oliva, Miren Sequera-Mutiozabal, Simona Gradari, Anisia Martínez-López, Blanca López-Chicheri, Neus Vidal-Vilar, Susana Aceituno, and Marta Cobo

Subjects
Coste-efectividad, Ciclosilicato de sodio y zirconio, Hiperpotasemia, Enfermedad renal crónica, Insuficiencia cardíaca, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Background and objective: Hyperkalemia (HK) is an electrolyte disturbance in the concentration of potassium ions (K+), whose risk increases in patients with chronic kidney disease (CKD) or heart failure (HF) and/or in patients being treated with renin–angiotensin–aldosterone system inhibitors (RAASi). The new oral K+ chelators offer a safe and effective treatment to maintain normokalemia in these patients. The objective of the analysis is to estimate the cost-effectiveness of sodium zirconium cyclosilicate (SZC) for the treatment of chronic HK in patients with CKD or HF versus standard treatment (calcium polystyrene sulfonate and lifestyle modifications) from the perspective of the Spanish National Health System. Materials and methods: Two microsimulation models reflecting the natural history of CKD and HF were used. In both models, K+ levels were simulated individually. Based on efficacy (reduction of K+ levels), quality of life of patients (utilities according to health states, and disutilities of events derived from each pathology and adverse events [AEs] of treatment) and costs considered (cost of treatment for HK, of RAASi treatment and its modification, health states, management of events derived from each pathology, HK episodes, and AEs treatment) (, 2022), clinical benefit (quality-adjusted life years [QALYs]) and cost results were obtained. A time horizon of the patient’s lifetime was used and a discount rate of 3% was applied for costs and outcomes. Results: SZC is a more effective option in both pathologies, with a difference in QALYs of 0.476 in CKD and 0.978 in HF compared to standard treatment, and it represents an incremental cost of 3,616 and 14,749, respectively, obtaining an incremental cost-utility ratio of 7,605/QALY in CKD and 15,078/QALY in HF. Conclusions: SZC is a cost-effective alternative for the treatment of HK in patients with CKD or HF, taking into account the reference efficiency values commonly used in Spain. Resumen: Antecedentes y objetivo: La hiperpotasemia (HK) es una alteración electrolítica en la concentración de iones potasio (K+), cuyo riesgo aumenta en pacientes con enfermedad renal crónica (ERC) o insuficiencia cardiaca (IC) y/o en pacientes en tratamiento con inhibidores del sistema renina-angiotensina-aldosterona (iSRAA). Los nuevos quelantes orales de K+ ofrecen un tratamiento seguro y eficaz para mantener la normopotasemia en estos pacientes. El objetivo del análisis es estimar el coste-efectividad del ciclosilicato de sodio y zirconio (CSZ) para el tratamiento de la HK crónica en pacientes con ERC o IC frente al tratamiento estándar (poliestireno sulfonato cálcico y modificaciones del estilo de vida) desde la perspectiva del Sistema Nacional de Salud (SNS) español. Materiales y métodos: Se utilizaron dos modelos de microsimulación que reflejan la historia natural de la ERC y de la IC. En ambos modelos se realizó una simulación de forma individual de los niveles de K+. En base a la eficacia (reducción de los niveles de K+), la calidad de vida de los pacientes (utilidades según estado de salud, y disutilidades de los eventos derivados de cada patología y los eventos adversos [EA] del tratamiento) y a los costes contemplados (coste del tratamiento para la HK, del tratamiento con iSRAA y su modificación, de los estados de salud, del manejo de los eventos derivados de cada patología, de los episodios de HK, y de los EA del tratamiento) (, 2022), se obtuvieron resultados de beneficio clínico (años de vida ajustados por calidad [AVAC]) y costes. Se empleó un horizonte temporal de toda la vida del paciente y se aplicó una tasa de descuento del 3% para costes y resultados. Resultados: El CSZ resulta una opción más efectiva en ambas patologías, con una diferencia de AVAC de 0,476 en ERC, y de 0,978 en IC frente al tratamiento estándar, y supone un coste incremental de 3.616 y 14.749 , respectivamente, obteniéndose un ratio coste-utilidad incremental (RCUI) de 7.605 /AVAC en ERC y 15.078 /AVAC en IC. Conclusiones: El CSZ es una alternativa con una buena relación coste-efectividad para el tratamiento de la HK en pacientes con ERC o IC, teniendo en cuenta los valores de eficiencia de referencia empleados habitualmente en España.

Published
2024
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25. Prognostic implications and diagnostic significance of TFE3 rearrangement in renal cell carcinoma

Author

Bastidas, Carmina Muñoz, Tapia, Mario Tapia, López, Andrés Calva, Cobo, Vanessa Talavera, Vives, Juan Colombas, Wong, Eduardo Miraval, Castané, Cristina Gutiérrez, Marckert, Francisco Javier Ancizu, Roca, Marcos Torres, Huerta, Luis Labairu, Alonso, Fernando Diez-Caballero, García, José Enrique Robles, Aubá, Felipe Villacampa, Padilla, Daniel González, López, Bernardino Miñana, and Zalabardo, Daniel Sánchez

Published
2024
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31. Microbiome mapping in dairy industry reveals new species and genes for probiotic and bioprotective activities

Author

De Filippis, Francesca, Valentino, Vincenzo, Yap, Min, Cabrera-Rubio, Raul, Barcenilla, Coral, Carlino, Niccolò, Cobo-Díaz, José F., Quijada, Narciso Martín, Calvete-Torre, Inés, Ruas-Madiedo, Patricia, Sabater, Carlos, Sequino, Giuseppina, Pasolli, Edoardo, Wagner, Martin, Margolles, Abelardo, Segata, Nicola, Álvarez-Ordóñez, Avelino, Cotter, Paul D., and Ercolini, Danilo

Published
2024
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37. The detailed analysis of the microbiome and resistome of artisanal blue-veined cheeses provides evidence on sources and patterns of succession linked with quality and safety traits

Author

Alexa, Elena A., Cobo-Díaz, José F., Renes, Erica, O´Callaghan, Tom F., Kilcawley, Kieran, Mannion, David, Skibinska, Iwona, Ruiz, Lorena, Margolles, Abelardo, Fernández-Gómez, Paula, Alvarez-Molina, Adrián, Puente-Gómez, Paula, Crispie, Fiona, López, Mercedes, Prieto, Miguel, Cotter, Paul D., and Alvarez-Ordóñez, Avelino

Published
2024
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40. The error of estimated GFR in predialysis care

Author

Escamilla-Cabrera, Beatriz, Luis-Lima, Sergio, Gallego-Valcarce, Eduardo, Sánchez-Dorta, Nuria Victoria, Negrín-Mena, Natalia, Díaz-Martín, Laura, Cruz-Perera, Coriolano, Hernández-Valles, Ana Monserrat, González-Rinne, Federico, Rodríguez-Gamboa, María José, Estupiñán-Torres, Sara, Miquel-Rodríguez, Rosa, Cobo-Caso, María Ángeles, Delgado-Mallén, Patricia, Fernández-Suárez, Gema, González-Rinne, Ana, Hernández-Barroso, Grimanesa, González-Delgado, Alejandra, Torres-Ramírez, Armando, Jiménez-Sosa, Alejandro, Ortiz, Alberto, Gaspari, Flavio, Hernández-Marrero, Domingo, and Porrini, Esteban Luis

Published
2024
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43. Low quality of maternal and child nutritional care at the primary care in Mexico: an urgent call to action for policymakers and stakeholders

Author

Ruiz, Omar Acosta, Ancira-Moreno, Monica, Omaña-Guzmán, Isabel, Cordero, Sonia Hernández, Morales, Arturo Cuauhtémoc Bautista, Navarro, Cecilia Pérez, Méndez, Soraya Burrola, Flores, Eric Monterrubio, Trejo, Alejandra, Kaufer-Horwitz, Martha, Cajero, Ariana, Sánchez, Belén, Bernat, Constanza, Salgado-Amador, Elder, Hoyos-Loya, Elizabeth, Mazariegos, Mónica, Manrique, Cinthya Muñoz, Cruz, Royer Pacheco, Mendoza, Elvia, Brero, Mauro, Sachse, Matthias, and Armijo, Fernanda Cobo

Published
2024
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44. Cyclosporine A in hospitalized COVID-19 pneumonia patients to prevent the development of interstitial lung disease: a pilot randomized clinical trial

Author

Cobo-Ibáñez, Tatiana, Mora Ortega, Gemma, Sánchez-Piedra, Carlos, Serralta-San Martín, Gonzalo, Thuissard-Vasallo, Israel J., Lores Gutiérrez, Vanesa, Soler Rangel, Llanos, García Yubero, Cristina, Esteban-Vázquez, Ana, López-Aspiroz, Elena, Andreu Vázquez, Cristina, Toboso, Inmaculada, Martínez Alonso de Armiño, Blanca María, Olivares Alviso, Rocío Alejandra, Calderón Nieto, Rocío, Yañez, Cecilia, Zakhour González, Marlín Alejandra, Sainz Sánchez, Tatiana, Arroyo de la Torre, Silvia, Del Amo Del Arco, Nazaret, Gómez-Cerezo, Jorge Francisco, Ramírez Prieto, Teresa, Martínez Hernández, Alicia, and Muñoz-Fernández, Santiago

Published
2024
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48. Improved sampling and DNA extraction procedures for microbiome analysis in food-processing environments

Author

Barcenilla, Coral, Cobo-Díaz, José F., De Filippis, Francesca, Valentino, Vincenzo, Cabrera Rubio, Raul, O’Neil, Dominic, Mahler de Sanchez, Lisa, Armanini, Federica, Carlino, Niccolò, Blanco-Míguez, Aitor, Pinto, Federica, Calvete-Torre, Inés, Sabater, Carlos, Delgado, Susana, Ruas-Madiedo, Patricia, Quijada, Narciso M., Dzieciol, Monika, Skírnisdóttir, Sigurlaug, Knobloch, Stephen, Puente, Alba, López, Mercedes, Prieto, Miguel, Marteinsson, Viggó Thór, Wagner, Martin, Margolles, Abelardo, Segata, Nicola, Cotter, Paul D., Ercolini, Danilo, and Alvarez-Ordóñez, Avelino

Published
2024
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